ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	5.52155322
2	muscle organ morphogenesis (GO:0048644)	4.65995045
3	cell wall macromolecule metabolic process (GO:0044036)	4.60168412
4	platelet dense granule organization (GO:0060155)	4.59212551
5	tongue development (GO:0043586)	4.29829270
6	cytochrome complex assembly (GO:0017004)	4.23216388
7	fibroblast migration (GO:0010761)	4.22950412
8	signal peptide processing (GO:0006465)	4.13112495
9	response to pheromone (GO:0019236)	4.12911982
10	protein neddylation (GO:0045116)	3.88273986
11	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.85496192
12	positive regulation of macrophage activation (GO:0043032)	3.81554278
13	regulation of glucokinase activity (GO:0033131)	3.68760380
14	regulation of hexokinase activity (GO:1903299)	3.68760380
15	lactate metabolic process (GO:0006089)	3.62499847
16	anterograde synaptic vesicle transport (GO:0048490)	3.61409459
17	regulation of cilium movement (GO:0003352)	3.57615625
18	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.43036912
19	regulation of meiosis I (GO:0060631)	3.40916424
20	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.38835922
21	female gonad development (GO:0008585)	3.38143975
22	response to nitrosative stress (GO:0051409)	3.34325007
23	respiratory chain complex IV assembly (GO:0008535)	3.29106241
24	glomerular basement membrane development (GO:0032836)	3.27336729
25	C4-dicarboxylate transport (GO:0015740)	3.21273463
26	S-adenosylmethionine metabolic process (GO:0046500)	3.19441356
27	positive regulation of respiratory burst (GO:0060267)	3.18709530
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.10211474
29	detection of light stimulus involved in visual perception (GO:0050908)	3.10211474
30	branched-chain amino acid catabolic process (GO:0009083)	3.09580704
31	establishment of protein localization to Golgi (GO:0072600)	3.08302105
32	protein complex biogenesis (GO:0070271)	3.05732377
33	acrosome reaction (GO:0007340)	3.01057822
34	photoreceptor cell maintenance (GO:0045494)	2.99928657
35	protein deneddylation (GO:0000338)	2.99080089
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99020539
37	protein targeting to Golgi (GO:0000042)	2.98193126
38	protein prenylation (GO:0018342)	2.97110909
39	prenylation (GO:0097354)	2.97110909
40	regulation of protein glycosylation (GO:0060049)	2.92915807
41	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.88206641
42	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.88206641
43	L-fucose metabolic process (GO:0042354)	2.84562063
44	L-fucose catabolic process (GO:0042355)	2.84562063
45	fucose catabolic process (GO:0019317)	2.84562063
46	tachykinin receptor signaling pathway (GO:0007217)	2.80416818
47	cullin deneddylation (GO:0010388)	2.78985279
48	replication fork processing (GO:0031297)	2.76434330
49	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.76330476
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.75559270
51	nonmotile primary cilium assembly (GO:0035058)	2.71242556
52	regulation of T cell chemotaxis (GO:0010819)	2.70070519
53	positive regulation of T cell chemotaxis (GO:0010820)	2.70070519
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68766185
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68766185
56	regulation of mitochondrial translation (GO:0070129)	2.65122875
57	opsonization (GO:0008228)	2.64536298
58	coenzyme catabolic process (GO:0009109)	2.63230976
59	keratinocyte development (GO:0003334)	2.61914003
60	righting reflex (GO:0060013)	2.59409129
61	DNA deamination (GO:0045006)	2.59010436
62	regulation of telomere maintenance (GO:0032204)	2.58513329
63	multicellular organism reproduction (GO:0032504)	2.58184477
64	vocalization behavior (GO:0071625)	2.56654177
65	negative regulation of telomere maintenance (GO:0032205)	2.56010753
66	left/right axis specification (GO:0070986)	2.54157320
67	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.53553936
68	intra-Golgi vesicle-mediated transport (GO:0006891)	2.50786082
69	proteasome assembly (GO:0043248)	2.50655542
70	tRNA methylation (GO:0030488)	2.50570898
71	sequestering of actin monomers (GO:0042989)	2.49883123
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49776310
73	axoneme assembly (GO:0035082)	2.48089083
74	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.47033644
75	protein heterotetramerization (GO:0051290)	2.46656834
76	response to interferon-beta (GO:0035456)	2.46601768
77	GMP metabolic process (GO:0046037)	2.46173627
78	vagina development (GO:0060068)	2.45546514
79	zinc ion transport (GO:0006829)	2.45280365
80	regulation of acrosome reaction (GO:0060046)	2.44296051
81	lipid particle organization (GO:0034389)	2.44213763
82	glycosphingolipid biosynthetic process (GO:0006688)	2.42104875
83	negative regulation of activin receptor signaling pathway (GO:0032926)	2.41186695
84	fusion of sperm to egg plasma membrane (GO:0007342)	2.40100188
85	intraciliary transport (GO:0042073)	2.39680202
86	mesenchymal-epithelial cell signaling (GO:0060638)	2.36436496
87	cytidine deamination (GO:0009972)	2.36274284
88	cytidine metabolic process (GO:0046087)	2.36274284
89	cytidine catabolic process (GO:0006216)	2.36274284
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.35443268
91	protein localization to Golgi apparatus (GO:0034067)	2.34714367
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.34713817
93	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.32442101
94	regulation of cellular amino acid metabolic process (GO:0006521)	2.31461767
95	female genitalia development (GO:0030540)	2.31036454
96	indolalkylamine metabolic process (GO:0006586)	2.30453482
97	biotin metabolic process (GO:0006768)	2.29968079
98	protein K6-linked ubiquitination (GO:0085020)	2.28991759
99	cellular response to zinc ion (GO:0071294)	2.27504419
100	fatty acid elongation (GO:0030497)	2.26644290

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.83822065
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.37948882
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.88878585
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.79901261
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.60786607
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55180178
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42370584
8	FUS_26573619_Chip-Seq_HEK293_Human	2.36214809
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35942139
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28189478
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.27408870
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22155458
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.16480597
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13650812
15	EWS_26573619_Chip-Seq_HEK293_Human	2.12929351
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.01199175
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.00036859
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98606980
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.98147689
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97403134
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.96741562
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96279118
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86796747
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83114042
25	VDR_22108803_ChIP-Seq_LS180_Human	1.79818817
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75054328
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.73593184
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.63958094
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63344338
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.63200783
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62051517
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61695384
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.61116834
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59186030
35	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.56492973
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.56316308
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56316308
38	NANOG_19829295_ChIP-Seq_ESCs_Human	1.54112611
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.54112611
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53640129
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.52253897
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51118428
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48959668
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.48457047
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44798322
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44194976
47	CJUN_26792858_Chip-Seq_BT549_Human	1.44017668
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43310232
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42210347
50	STAT3_23295773_ChIP-Seq_U87_Human	1.41773569
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38530735
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35394966
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35031914
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33544526
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.32747442
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31094333
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30630109
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.30011653
59	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.28836435
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28731246
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28466758
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26242834
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25427376
64	CDX2_22108803_ChIP-Seq_LS180_Human	1.24951129
65	TCF4_23295773_ChIP-Seq_U87_Human	1.23681303
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23338343
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22726523
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21574963
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21051952
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.19546029
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19506570
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18941594
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.18939607
74	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18514675
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17437100
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15288522
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14992858
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.14938355
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14334825
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13228207
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.12575408
82	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10788970
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10783622
84	AR_20517297_ChIP-Seq_VCAP_Human	1.10396948
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08974678
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08843576
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08383037
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07564114
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.06735247
90	PHF8_20622853_ChIP-Seq_HELA_Human	1.06080261
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03249849
92	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.02689743
93	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02658887
94	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01774989
95	TP53_22573176_ChIP-Seq_HFKS_Human	1.01707445
96	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01431365
97	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.99792803
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99459334
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99118707
100	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.98962170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	3.61540521
2	MP0000569_abnormal_digit_pigmentation	3.19522926
3	MP0001984_abnormal_olfaction	3.02092641
4	MP0003950_abnormal_plasma_membrane	3.01427317
5	MP0006054_spinal_hemorrhage	2.99613831
6	MP0002876_abnormal_thyroid_physiology	2.59179467
7	MP0009780_abnormal_chondrocyte_physiolo	2.56171199
8	MP0008877_abnormal_DNA_methylation	2.44223877
9	MP0005410_abnormal_fertilization	2.42499778
10	MP0003787_abnormal_imprinting	2.32547808
11	MP0005551_abnormal_eye_electrophysiolog	2.24129621
12	MP0002254_reproductive_system_inflammat	2.22735767
13	MP0001529_abnormal_vocalization	2.14705178
14	MP0004142_abnormal_muscle_tone	2.08600065
15	MP0003122_maternal_imprinting	2.04354873
16	MP0006072_abnormal_retinal_apoptosis	2.02649355
17	MP0002102_abnormal_ear_morphology	1.94802181
18	MP0003195_calcinosis	1.93784674
19	MP0005253_abnormal_eye_physiology	1.89894582
20	MP0006276_abnormal_autonomic_nervous	1.74862127
21	MP0002928_abnormal_bile_duct	1.67912455
22	MP0002166_altered_tumor_susceptibility	1.66485992
23	MP0003252_abnormal_bile_duct	1.62840184
24	MP0008789_abnormal_olfactory_epithelium	1.61127604
25	MP0000639_abnormal_adrenal_gland	1.60783275
26	MP0002090_abnormal_vision	1.60135333
27	MP0002736_abnormal_nociception_after	1.56502662
28	MP0001485_abnormal_pinna_reflex	1.51414071
29	MP0000538_abnormal_urinary_bladder	1.51328781
30	MP0009697_abnormal_copulation	1.43669886
31	MP0003646_muscle_fatigue	1.43111303
32	MP0009250_abnormal_appendicular_skeleto	1.36274912
33	MP0002132_abnormal_respiratory_system	1.33557410
34	MP0002277_abnormal_respiratory_mucosa	1.32853130
35	MP0005310_abnormal_salivary_gland	1.31860095
36	MP0002006_tumorigenesis	1.31099469
37	MP0008872_abnormal_physiological_respon	1.28747154
38	MP0003786_premature_aging	1.28102608
39	MP0002168_other_aberrant_phenotype	1.27651341
40	MP0001299_abnormal_eye_distance/	1.25684260
41	MP0002282_abnormal_trachea_morphology	1.23664148
42	MP0003121_genomic_imprinting	1.23107955
43	MP0001986_abnormal_taste_sensitivity	1.22011062
44	MP0005084_abnormal_gallbladder_morpholo	1.16683224
45	MP0002933_joint_inflammation	1.15623206
46	MP0004133_heterotaxia	1.12545833
47	MP0005646_abnormal_pituitary_gland	1.11948535
48	MP0005174_abnormal_tail_pigmentation	1.10130044
49	MP0005389_reproductive_system_phenotype	1.07170592
50	MP0003011_delayed_dark_adaptation	1.06287518
51	MP0001968_abnormal_touch/_nociception	1.03165464
52	MP0001486_abnormal_startle_reflex	1.01664426
53	MP0002233_abnormal_nose_morphology	0.99757074
54	MP0003937_abnormal_limbs/digits/tail_de	0.99585276
55	MP0000647_abnormal_sebaceous_gland	0.97960952
56	MP0001661_extended_life_span	0.95784282
57	MP0002009_preneoplasia	0.95292412
58	MP0002160_abnormal_reproductive_system	0.94709891
59	MP0010386_abnormal_urinary_bladder	0.94146318
60	MP0001119_abnormal_female_reproductive	0.93129062
61	MP0006082_CNS_inflammation	0.91527061
62	MP0004883_abnormal_blood_vessel	0.90184289
63	MP0004084_abnormal_cardiac_muscle	0.90020498
64	MP0005503_abnormal_tendon_morphology	0.89254884
65	MP0001756_abnormal_urination	0.89215376
66	MP0002837_dystrophic_cardiac_calcinosis	0.89197378
67	MP0000230_abnormal_systemic_arterial	0.87725780
68	MP0008875_abnormal_xenobiotic_pharmacok	0.86130334
69	MP0005075_abnormal_melanosome_morpholog	0.84407938
70	MP0005379_endocrine/exocrine_gland_phen	0.83376657
71	MP0008007_abnormal_cellular_replicative	0.82721119
72	MP0000427_abnormal_hair_cycle	0.81931127
73	MP0003045_fibrosis	0.78546466
74	MP0004145_abnormal_muscle_electrophysio	0.77845185
75	MP0003755_abnormal_palate_morphology	0.76722915
76	MP0005395_other_phenotype	0.76669247
77	MP0002115_abnormal_skeleton_extremities	0.76631981
78	MP0005367_renal/urinary_system_phenotyp	0.74850820
79	MP0000516_abnormal_urinary_system	0.74850820
80	MP0005647_abnormal_sex_gland	0.73870948
81	MP0005220_abnormal_exocrine_pancreas	0.73356880
82	MP0003448_altered_tumor_morphology	0.72866731
83	MP0003186_abnormal_redox_activity	0.72675794
84	MP0002751_abnormal_autonomic_nervous	0.70280658
85	MP0005023_abnormal_wound_healing	0.69947934
86	MP0008775_abnormal_heart_ventricle	0.69360195
87	MP0004147_increased_porphyrin_level	0.69144411
88	MP0001963_abnormal_hearing_physiology	0.68943051
89	MP0005671_abnormal_response_to	0.66268463
90	MP0005187_abnormal_penis_morphology	0.65652627
91	MP0001929_abnormal_gametogenesis	0.65384471
92	MP0008058_abnormal_DNA_repair	0.65115154
93	MP0005166_decreased_susceptibility_to	0.63855536
94	MP0000013_abnormal_adipose_tissue	0.62148723
95	MP0001764_abnormal_homeostasis	0.60575256
96	MP0002127_abnormal_cardiovascular_syste	0.59936293
97	MP0000681_abnormal_thyroid_gland	0.59376165
98	MP0002109_abnormal_limb_morphology	0.59340902
99	MP0000653_abnormal_sex_gland	0.58652336
100	MP0009764_decreased_sensitivity_to	0.58309052

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neonatal respiratory distress (HP:0002643)	4.33388316
2	True hermaphroditism (HP:0010459)	3.86114255
3	Medial flaring of the eyebrow (HP:0010747)	3.63519369
4	Hypoplastic iliac wings (HP:0002866)	3.26452026
5	Hypoproteinemia (HP:0003075)	3.19694840
6	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.14204697
7	Congenital primary aphakia (HP:0007707)	3.07736248
8	Pancreatic cysts (HP:0001737)	3.05093771
9	Pancreatic fibrosis (HP:0100732)	3.05015417
10	Long clavicles (HP:0000890)	3.04304974
11	Supernumerary spleens (HP:0009799)	2.99971529
12	Gait imbalance (HP:0002141)	2.94054264
13	Anencephaly (HP:0002323)	2.93247587
14	Acute necrotizing encephalopathy (HP:0006965)	2.81877822
15	Type 2 muscle fiber atrophy (HP:0003554)	2.79203225
16	Tubular atrophy (HP:0000092)	2.72533363
17	Mesomelia (HP:0003027)	2.69338876
18	Progressive macrocephaly (HP:0004481)	2.69144602
19	Congenital stationary night blindness (HP:0007642)	2.67762538
20	Short middle phalanx of the 5th finger (HP:0004220)	2.65851793
21	Abnormal albumin level (HP:0012116)	2.60905605
22	Hypoalbuminemia (HP:0003073)	2.60905605
23	Nephrogenic diabetes insipidus (HP:0009806)	2.58435720
24	Abnormality of midbrain morphology (HP:0002418)	2.58320195
25	Molar tooth sign on MRI (HP:0002419)	2.58320195
26	Hypothermia (HP:0002045)	2.57762620
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.56087884
28	Aplastic anemia (HP:0001915)	2.54857142
29	Acute encephalopathy (HP:0006846)	2.53897743
30	Nephronophthisis (HP:0000090)	2.46182244
31	Attenuation of retinal blood vessels (HP:0007843)	2.45627303
32	Mitochondrial inheritance (HP:0001427)	2.44419466
33	Vaginal atresia (HP:0000148)	2.38531618
34	Abnormality of the renal cortex (HP:0011035)	2.35541083
35	Abnormality of the renal medulla (HP:0100957)	2.31758655
36	Abnormal drinking behavior (HP:0030082)	2.31681835
37	Polydipsia (HP:0001959)	2.31681835
38	Microglossia (HP:0000171)	2.30261902
39	Delayed gross motor development (HP:0002194)	2.30256655
40	Acute hepatic failure (HP:0006554)	2.30154747
41	Type II lissencephaly (HP:0007260)	2.28519587
42	Genital tract atresia (HP:0001827)	2.27776809
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25651875
44	Abolished electroretinogram (ERG) (HP:0000550)	2.23310487
45	Increased CSF lactate (HP:0002490)	2.23172121
46	Pancreatic islet-cell hyperplasia (HP:0004510)	2.22211288
47	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.20059343
48	Polyuria (HP:0000103)	2.11819210
49	Constricted visual fields (HP:0001133)	2.07503634
50	Thyroiditis (HP:0100646)	2.06748032
51	Postaxial foot polydactyly (HP:0001830)	2.06010306
52	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.04926075
53	Abnormality of T cell number (HP:0011839)	2.03950413
54	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.03162751
55	Posterior subcapsular cataract (HP:0007787)	2.02625769
56	Disproportionate short-trunk short stature (HP:0003521)	2.02261841
57	Hyperventilation (HP:0002883)	2.02169033
58	Abnormality of the wing of the ilium (HP:0011867)	2.02143653
59	Sex reversal (HP:0012245)	2.02000792
60	Abnormal sex determination (HP:0012244)	2.02000792
61	Male pseudohermaphroditism (HP:0000037)	2.01107105
62	Cerebral edema (HP:0002181)	1.99590214
63	Chronic hepatic failure (HP:0100626)	1.97244324
64	Postaxial hand polydactyly (HP:0001162)	1.96854422
65	Bile duct proliferation (HP:0001408)	1.93441249
66	Abnormal biliary tract physiology (HP:0012439)	1.93441249
67	Muscle fiber atrophy (HP:0100295)	1.93324980
68	Optic disc pallor (HP:0000543)	1.92524891
69	Aplasia/Hypoplasia of the lens (HP:0008063)	1.92200076
70	Respiratory failure (HP:0002878)	1.91417246
71	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.89757429
72	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.89139589
73	Oral leukoplakia (HP:0002745)	1.89082106
74	Hematochezia (HP:0002573)	1.88911400
75	Hyperinsulinemic hypoglycemia (HP:0000825)	1.88287627
76	Occipital encephalocele (HP:0002085)	1.87859402
77	Delayed puberty (HP:0000823)	1.85600207
78	Albinism (HP:0001022)	1.84208370
79	Increased corneal curvature (HP:0100692)	1.84096258
80	Keratoconus (HP:0000563)	1.84096258
81	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82504949
82	Hepatocellular necrosis (HP:0001404)	1.82480402
83	Dandy-Walker malformation (HP:0001305)	1.82187713
84	Hypoplastic scapulae (HP:0000882)	1.81588769
85	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.81588769
86	Absent frontal sinuses (HP:0002688)	1.81473498
87	Sclerocornea (HP:0000647)	1.81061757
88	Metaphyseal dysplasia (HP:0100255)	1.79445550
89	Congenital hepatic fibrosis (HP:0002612)	1.77603661
90	Progressive inability to walk (HP:0002505)	1.77219115
91	Cystic liver disease (HP:0006706)	1.76881355
92	Follicular hyperkeratosis (HP:0007502)	1.75947529
93	Exercise-induced muscle cramps (HP:0003710)	1.75929852
94	Hypomagnesemia (HP:0002917)	1.74114162
95	Decreased muscle mass (HP:0003199)	1.72091015
96	T lymphocytopenia (HP:0005403)	1.71863279
97	Poor coordination (HP:0002370)	1.71769191
98	Hypoplastic ischia (HP:0003175)	1.71496551
99	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.70191735
100	Left ventricular hypertrophy (HP:0001712)	1.68992960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.84579464
2	MAP4K2	4.58804647
3	INSRR	2.95816153
4	MST4	2.50250728
5	TXK	2.35647279
6	GRK1	2.12356813
7	BCR	2.09876907
8	PAK3	2.07939128
9	PLK2	2.05294008
10	OXSR1	1.97712822
11	MUSK	1.92015906
12	PTK2B	1.90095173
13	BRSK2	1.87610438
14	BMPR1B	1.85812699
15	NUAK1	1.80808725
16	ADRBK2	1.74865870
17	PBK	1.73648571
18	BCKDK	1.71487037
19	WNK3	1.70713052
20	ZAK	1.68173423
21	STK39	1.63459974
22	PLK3	1.59385510
23	STK38L	1.56536729
24	PNCK	1.50699988
25	TAF1	1.48964194
26	STK16	1.36730307
27	CAMKK2	1.34166678
28	MAPKAPK3	1.31880398
29	NEK9	1.29538603
30	MAP3K4	1.27487521
31	EIF2AK3	1.22353227
32	TRIM28	1.15673924
33	MAPK13	1.07655845
34	CSNK1G1	1.03309499
35	TSSK6	0.99622802
36	MAP3K6	0.95830929
37	NLK	0.90763412
38	ACVR1B	0.90441384
39	PRKCE	0.90028489
40	TNIK	0.87256211
41	MAP3K12	0.86520947
42	BMPR2	0.85731833
43	TYK2	0.85071702
44	FER	0.83996050
45	KDR	0.79378857
46	PINK1	0.78895381
47	MAP2K7	0.78737480
48	TAOK3	0.78367730
49	VRK2	0.77405692
50	SRPK1	0.77041589
51	AKT3	0.74345354
52	JAK1	0.72050152
53	VRK1	0.70422124
54	OBSCN	0.69501055
55	FLT3	0.69496859
56	SGK2	0.69164805
57	MKNK2	0.68672815
58	BRSK1	0.67939371
59	CSNK1G3	0.67117193
60	CSNK1A1L	0.65394398
61	CSNK1G2	0.63213080
62	BRD4	0.62034343
63	DDR2	0.57736532
64	MYLK	0.56934226
65	ROCK1	0.54938917
66	PASK	0.53306697
67	TNK2	0.52308500
68	ERBB3	0.51947588
69	WEE1	0.50631740
70	FGFR2	0.49305566
71	NME1	0.48364846
72	STK3	0.48311867
73	CSF1R	0.46524077
74	KIT	0.46256716
75	IRAK1	0.45960694
76	GRK5	0.45690450
77	NEK6	0.43848739
78	ADRBK1	0.41932346
79	PIK3CA	0.41684748
80	IKBKE	0.41301723
81	MAP3K2	0.40973286
82	TIE1	0.38866148
83	DAPK1	0.38267224
84	TGFBR1	0.36040165
85	ABL1	0.35346462
86	RPS6KA4	0.34282022
87	PLK1	0.32916015
88	DAPK2	0.32550704
89	IGF1R	0.31603901
90	MKNK1	0.31232028
91	EPHA4	0.30311207
92	EIF2AK2	0.29886119
93	FGFR1	0.27605168
94	CASK	0.26163573
95	CAMK2A	0.25870450
96	GRK7	0.24961167
97	RPS6KA5	0.24928766
98	ERBB4	0.24475773
99	CAMK2D	0.23069810
100	ITK	0.22643714

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.76302002
2	Proteasome_Homo sapiens_hsa03050	3.35752068
3	Propanoate metabolism_Homo sapiens_hsa00640	2.90901547
4	RNA polymerase_Homo sapiens_hsa03020	2.51104038
5	Basal transcription factors_Homo sapiens_hsa03022	2.23637299
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18414493
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12146201
8	One carbon pool by folate_Homo sapiens_hsa00670	2.06298523
9	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85806137
10	Phototransduction_Homo sapiens_hsa04744	1.85695756
11	Fatty acid elongation_Homo sapiens_hsa00062	1.78291523
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.78256439
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.68300597
14	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.59201688
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58889266
16	Homologous recombination_Homo sapiens_hsa03440	1.53624823
17	Regulation of autophagy_Homo sapiens_hsa04140	1.53588749
18	Butanoate metabolism_Homo sapiens_hsa00650	1.47995659
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42322395
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41194106
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40876944
22	Circadian rhythm_Homo sapiens_hsa04710	1.38484108
23	Parkinsons disease_Homo sapiens_hsa05012	1.37306773
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.35274794
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.32750238
26	Peroxisome_Homo sapiens_hsa04146	1.30678082
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.29393303
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.27383262
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26791962
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25421325
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.22500940
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18215362
33	RNA degradation_Homo sapiens_hsa03018	1.16599969
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14677502
35	Glutathione metabolism_Homo sapiens_hsa00480	1.14359077
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13788495
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12978893
38	Purine metabolism_Homo sapiens_hsa00230	1.09008512
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05271946
40	Caffeine metabolism_Homo sapiens_hsa00232	1.00210408
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97341630
42	Retinol metabolism_Homo sapiens_hsa00830	0.94996684
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94766788
44	Legionellosis_Homo sapiens_hsa05134	0.94262458
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93344906
46	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93003508
47	DNA replication_Homo sapiens_hsa03030	0.92642795
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91962695
49	Mismatch repair_Homo sapiens_hsa03430	0.91032018
50	Base excision repair_Homo sapiens_hsa03410	0.90593494
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89744492
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88704276
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88370004
54	Huntingtons disease_Homo sapiens_hsa05016	0.86668339
55	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.83443725
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.83160223
57	Olfactory transduction_Homo sapiens_hsa04740	0.82682139
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.81024981
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.76445268
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75575459
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.75263824
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.74903418
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74779193
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73431887
65	RNA transport_Homo sapiens_hsa03013	0.73036762
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72762006
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.72265358
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72037099
69	Alzheimers disease_Homo sapiens_hsa05010	0.71809565
70	Fatty acid degradation_Homo sapiens_hsa00071	0.70346089
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69924740
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.68748228
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.66470563
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.63653362
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63263807
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63083642
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62537792
78	Mineral absorption_Homo sapiens_hsa04978	0.62445217
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61988264
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.61238194
81	Metabolic pathways_Homo sapiens_hsa01100	0.59070653
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.58716577
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58583445
84	Allograft rejection_Homo sapiens_hsa05330	0.58231784
85	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52802864
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51713045
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51073101
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49577920
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48362726
90	p53 signaling pathway_Homo sapiens_hsa04115	0.48135163
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46291280
92	Salivary secretion_Homo sapiens_hsa04970	0.46128135
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45340096
94	Sulfur relay system_Homo sapiens_hsa04122	0.39638607
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39448377
96	Asthma_Homo sapiens_hsa05310	0.37153933
97	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.36971628
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35237540
99	Measles_Homo sapiens_hsa05162	0.34005025
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31221444

SUMO2P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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