SUMO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)6.14771930
2DNA strand elongation involved in DNA replication (GO:0006271)5.56582142
3telomere maintenance via semi-conservative replication (GO:0032201)5.51844650
4ribosomal small subunit assembly (GO:0000028)5.48476194
5DNA strand elongation (GO:0022616)5.28834013
6DNA deamination (GO:0045006)4.94390770
7DNA replication initiation (GO:0006270)4.91786325
8telomere maintenance via recombination (GO:0000722)4.88490105
9DNA unwinding involved in DNA replication (GO:0006268)4.70259956
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.58866922
11mitotic recombination (GO:0006312)4.51318998
12nucleobase biosynthetic process (GO:0046112)4.49029852
13cullin deneddylation (GO:0010388)4.36142810
14telomere maintenance via telomere lengthening (GO:0010833)4.28728514
15protein deneddylation (GO:0000338)4.28545835
16DNA replication checkpoint (GO:0000076)4.28164922
17maturation of SSU-rRNA (GO:0030490)4.27498270
18purine nucleobase biosynthetic process (GO:0009113)4.26364537
19negative regulation of release of cytochrome c from mitochondria (GO:0090201)4.22818125
20nucleotide-excision repair, DNA gap filling (GO:0006297)4.16060342
21peptidyl-arginine omega-N-methylation (GO:0035247)4.11084872
22nuclear envelope reassembly (GO:0031468)4.07537576
23mitotic nuclear envelope reassembly (GO:0007084)4.07537576
24viral transcription (GO:0019083)4.07319223
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.02977049
26proteasome assembly (GO:0043248)4.02430036
27protein retention in ER lumen (GO:0006621)4.01611201
28translational termination (GO:0006415)3.99617193
29folic acid-containing compound biosynthetic process (GO:0009396)3.93917048
30cotranslational protein targeting to membrane (GO:0006613)3.92608899
31IMP biosynthetic process (GO:0006188)3.92068611
32protein targeting to ER (GO:0045047)3.89528975
33pentose-phosphate shunt (GO:0006098)3.89060424
34formation of translation preinitiation complex (GO:0001731)3.84198720
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.83911230
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.79171797
37CENP-A containing nucleosome assembly (GO:0034080)3.79132878
38translational elongation (GO:0006414)3.77467217
39establishment of integrated proviral latency (GO:0075713)3.75582424
40ribosomal small subunit biogenesis (GO:0042274)3.75305089
41chromatin remodeling at centromere (GO:0031055)3.73268909
42DNA replication-dependent nucleosome assembly (GO:0006335)3.70286075
43DNA replication-dependent nucleosome organization (GO:0034723)3.70286075
44protein localization to endoplasmic reticulum (GO:0070972)3.68250984
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66378078
46proline biosynthetic process (GO:0006561)3.61431118
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59955754
48regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59509221
49spliceosomal snRNP assembly (GO:0000387)3.56681647
50pseudouridine synthesis (GO:0001522)3.52756926
51pinocytosis (GO:0006907)3.48012940
52transcription-coupled nucleotide-excision repair (GO:0006283)3.45467491
53ribonucleoprotein complex biogenesis (GO:0022613)3.45435750
54IMP metabolic process (GO:0046040)3.44808888
55DNA replication-independent nucleosome assembly (GO:0006336)3.44272367
56DNA replication-independent nucleosome organization (GO:0034724)3.44272367
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42758918
58translational initiation (GO:0006413)3.42711568
59ribosome biogenesis (GO:0042254)3.42219530
60histone arginine methylation (GO:0034969)3.41402833
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40118542
62ribosomal large subunit biogenesis (GO:0042273)3.39859295
63protein localization to kinetochore (GO:0034501)3.38150357
64NADPH regeneration (GO:0006740)3.36797413
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35098646
66deoxyribonucleotide biosynthetic process (GO:0009263)3.34500115
67pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.33744939
68glucose catabolic process (GO:0006007)3.32573278
69UV protection (GO:0009650)3.31564315
70negative regulation of ligase activity (GO:0051352)3.27861826
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27861826
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27545086
73positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.26762058
74cell cycle G1/S phase transition (GO:0044843)3.26051147
75G1/S transition of mitotic cell cycle (GO:0000082)3.26051147
76viral life cycle (GO:0019058)3.25279661
77pteridine-containing compound biosynthetic process (GO:0042559)3.24621453
78rRNA processing (GO:0006364)3.23302563
79rRNA modification (GO:0000154)3.23025212
80histone H2A acetylation (GO:0043968)3.22760807
81cellular protein complex disassembly (GO:0043624)3.22540944
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22072798
83translation (GO:0006412)3.21017808
84deoxyribose phosphate biosynthetic process (GO:0046385)3.20604566
852-deoxyribonucleotide biosynthetic process (GO:0009265)3.20604566
86viral mRNA export from host cell nucleus (GO:0046784)3.18421042
87peptidyl-arginine methylation (GO:0018216)3.16691939
88peptidyl-arginine N-methylation (GO:0035246)3.16691939
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16229101
90telomere organization (GO:0032200)3.15086834
91mitochondrial calcium ion transport (GO:0006851)3.13937129
92spliceosomal complex assembly (GO:0000245)3.13418224
93telomere maintenance (GO:0000723)3.12575333
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11882071
95regulation of nuclear cell cycle DNA replication (GO:0033262)3.11230111
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10748720
97Golgi transport vesicle coating (GO:0048200)3.08781647
98COPI coating of Golgi vesicle (GO:0048205)3.08781647
99rRNA metabolic process (GO:0016072)3.08425954
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06856252
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06734569
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06734569
103oxidative phosphorylation (GO:0006119)3.06189125
104deoxyribonucleotide catabolic process (GO:0009264)3.04717877
105nucleobase-containing small molecule interconversion (GO:0015949)3.03986644
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03655793
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03655793
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03655793
109mitotic nuclear envelope disassembly (GO:0007077)3.02867325
110maturation of 5.8S rRNA (GO:0000460)3.02702454
111postreplication repair (GO:0006301)3.02307249
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00785764
113transcription elongation from RNA polymerase III promoter (GO:0006385)3.00723891
114termination of RNA polymerase III transcription (GO:0006386)3.00723891
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00068795
116pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98185132
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97113921
118deoxyribose phosphate catabolic process (GO:0046386)2.97104634
119pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97041168
120deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95950922
121protein complex disassembly (GO:0043241)2.95637157
122pyrimidine nucleotide catabolic process (GO:0006244)2.95202215
123cellular component biogenesis (GO:0044085)2.95174314
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.95130027
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95130027
126negative regulation of RNA splicing (GO:0033119)2.95058733
127establishment of viral latency (GO:0019043)2.94631119
128pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.94396964
129pentose metabolic process (GO:0019321)2.91675023
130purine nucleotide salvage (GO:0032261)2.90623186
131mitotic chromosome condensation (GO:0007076)2.89952543
1322-deoxyribonucleotide metabolic process (GO:0009394)2.88841488
133regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87744662
134regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.86967707
135positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.86967707
136protein-DNA complex disassembly (GO:0032986)2.84849493
137nucleosome disassembly (GO:0006337)2.84849493
138nucleoside diphosphate biosynthetic process (GO:0009133)2.84503238
139autophagic vacuole fusion (GO:0000046)2.83418280
140positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82101336
141de novo protein folding (GO:0006458)2.80934093
142deoxyribose phosphate metabolic process (GO:0019692)2.80697268
143de novo posttranslational protein folding (GO:0051084)2.80593356
144regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.80388007
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79607606
146nucleotide salvage (GO:0043173)2.79514712
147protoporphyrinogen IX metabolic process (GO:0046501)2.78935029
148barbed-end actin filament capping (GO:0051016)2.75548843
149lipopolysaccharide biosynthetic process (GO:0009103)2.74288337
150iron-sulfur cluster assembly (GO:0016226)2.73465040
151metallo-sulfur cluster assembly (GO:0031163)2.73465040
152protein localization to endosome (GO:0036010)2.72998302
153purine deoxyribonucleotide catabolic process (GO:0009155)2.71795087
154NADH metabolic process (GO:0006734)2.71538203
155adenine nucleotide transport (GO:0051503)2.70685187
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67199575
157deoxyribonucleotide metabolic process (GO:0009262)2.64340208
158regulation of release of cytochrome c from mitochondria (GO:0090199)2.63691360
159chaperone mediated protein folding requiring cofactor (GO:0051085)2.62013122
160negative regulation of erythrocyte differentiation (GO:0045647)2.61371283
161guanosine-containing compound biosynthetic process (GO:1901070)2.58909325
162negative regulation of cell size (GO:0045792)2.58438508
163negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.57811383
164prostaglandin biosynthetic process (GO:0001516)2.57224666
165prostanoid biosynthetic process (GO:0046457)2.57224666
166virion assembly (GO:0019068)2.56299164
167pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54632532
168heme biosynthetic process (GO:0006783)2.46867282
169spliceosomal tri-snRNP complex assembly (GO:0000244)2.44586353
170deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.42968443
171positive regulation of receptor biosynthetic process (GO:0010870)2.41936889
172extracellular fibril organization (GO:0043206)2.41480210
173mitochondrial fusion (GO:0008053)2.40772551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.52771007
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.48614465
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21395661
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84126074
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.41238952
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.40078992
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33529290
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32472751
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26925981
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19908417
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.08640651
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.02558418
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94813537
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93287505
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78643479
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75869142
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.52784871
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49972804
19* XRN2_22483619_ChIP-Seq_HELA_Human2.46921787
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36844337
21VDR_23849224_ChIP-Seq_CD4+_Human2.33175700
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32563053
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31506784
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31311204
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25414093
26ZNF263_19887448_ChIP-Seq_K562_Human2.20058159
27DCP1A_22483619_ChIP-Seq_HELA_Human2.18916459
28FOXP3_21729870_ChIP-Seq_TREG_Human2.16268613
29GABP_19822575_ChIP-Seq_HepG2_Human2.14634440
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11176495
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07729610
32TTF2_22483619_ChIP-Seq_HELA_Human2.05959090
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96494562
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96412529
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94246256
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89382078
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.88404950
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.87941972
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87247901
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86141278
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85508588
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84624410
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84130920
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83263346
45AR_21909140_ChIP-Seq_LNCAP_Human1.82055633
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81426200
47CIITA_25753668_ChIP-Seq_RAJI_Human1.80875132
48* SRF_21415370_ChIP-Seq_HL-1_Mouse1.79665600
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77484388
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77273647
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.77080597
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70925661
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69859855
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68881106
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68821150
56* LXR_22292898_ChIP-Seq_THP-1_Human1.67797885
57ELK1_19687146_ChIP-ChIP_HELA_Human1.67263601
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64305577
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62463543
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61741659
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60048871
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58447121
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57018166
64* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56763503
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.49104306
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47953040
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43101917
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.42313541
69RACK7_27058665_Chip-Seq_MCF-7_Human1.37223827
70MYC_22102868_ChIP-Seq_BL_Human1.33890468
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32277859
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31269505
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29871550
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27152885
75KDM5A_27292631_Chip-Seq_BREAST_Human1.26770878
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.25286449
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25235880
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22171073
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21574659
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.21490703
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19784167
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17594095
83P68_20966046_ChIP-Seq_HELA_Human1.15839742
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.15782658
85MYC_18940864_ChIP-ChIP_HL60_Human1.15547965
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15176649
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14549538
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13527647
89NCOR1_26117541_ChIP-Seq_K562_Human1.12146545
90TFEB_21752829_ChIP-Seq_HELA_Human1.10516472
91* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09970192
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08713536
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08140821
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07575448
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05543183
96CLOCK_20551151_ChIP-Seq_293T_Human1.05398747
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04879545
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04717262
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04510768
100* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04021699
101VDR_24763502_ChIP-Seq_THP-1_Human1.03672616
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03267018
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.03264879
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02066938
105* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02048510
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01816077
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99712932
108BCL6_27268052_Chip-Seq_Bcells_Human0.99462224
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.99368489
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99253904
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98777292
112* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97081272
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95937410
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94721522
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94092953
116* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92796002
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91649427
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90187764
119SPI1_23547873_ChIP-Seq_NB4_Human0.89384336
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87905093
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86732076
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84636534
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82315498
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81817860
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81702448
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79339677
127VDR_21846776_ChIP-Seq_THP-1_Human0.77280606
128* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76661134
129* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74976617
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71536261
131* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71527244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41971267
2MP0010094_abnormal_chromosome_stability4.51253971
3MP0004957_abnormal_blastocyst_morpholog4.40408562
4MP0005058_abnormal_lysosome_morphology4.36345276
5MP0003111_abnormal_nucleus_morphology3.72843131
6MP0003123_paternal_imprinting3.72186740
7MP0003077_abnormal_cell_cycle3.69263017
8MP0008057_abnormal_DNA_replication3.35843823
9MP0008058_abnormal_DNA_repair3.33203559
10MP0005464_abnormal_platelet_physiology3.29551796
11MP0008007_abnormal_cellular_replicative3.22290148
12MP0009278_abnormal_bone_marrow3.20017259
13MP0002396_abnormal_hematopoietic_system2.79279817
14MP0008260_abnormal_autophagy2.73512832
15MP0005451_abnormal_body_composition2.69132511
16MP0006054_spinal_hemorrhage2.68650986
17MP0008932_abnormal_embryonic_tissue2.63965691
18MP0008877_abnormal_DNA_methylation2.57192439
19MP0003191_abnormal_cellular_cholesterol2.43243613
20MP0009379_abnormal_foot_pigmentation2.43010832
21MP0009840_abnormal_foam_cell2.42833644
22MP0003705_abnormal_hypodermis_morpholog2.24598894
23MP0003121_genomic_imprinting2.19949294
24MP0000490_abnormal_crypts_of2.06481949
25MP0006292_abnormal_olfactory_placode1.99274443
26MP0003122_maternal_imprinting1.97119390
27MP0005501_abnormal_skin_physiology1.94488267
28MP0000350_abnormal_cell_proliferation1.90892806
29MP0003786_premature_aging1.80520139
30MP0000343_altered_response_to1.77349599
31MP0001730_embryonic_growth_arrest1.76157052
32MP0010030_abnormal_orbit_morphology1.75768598
33MP0004233_abnormal_muscle_weight1.73510323
34MP0004185_abnormal_adipocyte_glucose1.71953181
35MP0002938_white_spotting1.59843442
36MP0000681_abnormal_thyroid_gland1.57965045
37MP0005165_increased_susceptibility_to1.56274427
38MP0004808_abnormal_hematopoietic_stem1.55500394
39MP0003566_abnormal_cell_adhesion1.51745086
40MP0003075_altered_response_to1.50792511
41MP0003315_abnormal_perineum_morphology1.48505196
42MP0002796_impaired_skin_barrier1.45845731
43MP0005083_abnormal_biliary_tract1.45750432
44MP0001727_abnormal_embryo_implantation1.45637140
45MP0003656_abnormal_erythrocyte_physiolo1.42050420
46MP0000313_abnormal_cell_death1.39899687
47MP0006036_abnormal_mitochondrial_physio1.39878457
48MP0005220_abnormal_exocrine_pancreas1.37551644
49MP0002080_prenatal_lethality1.37539635
50MP0001697_abnormal_embryo_size1.35789697
51MP0002160_abnormal_reproductive_system1.35535098
52MP0003329_amyloid_beta_deposits1.34892146
53MP0000678_abnormal_parathyroid_gland1.34846984
54MP0002019_abnormal_tumor_incidence1.33950942
55MP0003186_abnormal_redox_activity1.32620255
56MP0001849_ear_inflammation1.31162579
57MP0002148_abnormal_hypersensitivity_rea1.26961993
58MP0001188_hyperpigmentation1.26276609
59MP0001881_abnormal_mammary_gland1.26223333
60MP0000358_abnormal_cell_content/1.24643479
61MP0008789_abnormal_olfactory_epithelium1.21324300
62MP0000750_abnormal_muscle_regeneration1.20744947
63MP0001529_abnormal_vocalization1.19647369
64MP0001853_heart_inflammation1.19010628
65MP0001542_abnormal_bone_strength1.18021402
66MP0000751_myopathy1.15175554
67MP0005257_abnormal_intraocular_pressure1.14483539
68MP0002210_abnormal_sex_determination1.14238872
69MP0003567_abnormal_fetal_cardiomyocyte1.13118992
70MP0003718_maternal_effect1.12686718
71MP0008438_abnormal_cutaneous_collagen1.12615289
72MP0001672_abnormal_embryogenesis/_devel1.11741649
73MP0005380_embryogenesis_phenotype1.11741649
74MP0002085_abnormal_embryonic_tissue1.09823839
75MP0004858_abnormal_nervous_system1.08962349
76MP0001545_abnormal_hematopoietic_system1.08757520
77MP0005397_hematopoietic_system_phenotyp1.08757520
78MP0003119_abnormal_digestive_system1.06901701
79MP0000747_muscle_weakness1.06631214
80MP0009697_abnormal_copulation1.05398262
81MP0003890_abnormal_embryonic-extraembry1.04749395
82MP0003806_abnormal_nucleotide_metabolis1.04650038
83MP0002095_abnormal_skin_pigmentation1.02249944
84MP0003984_embryonic_growth_retardation1.01273998
85MP0000566_synostosis1.00392215
86MP0001145_abnormal_male_reproductive1.00083982
87MP0005394_taste/olfaction_phenotype0.98872558
88MP0005499_abnormal_olfactory_system0.98872558
89MP0002132_abnormal_respiratory_system0.98606296
90MP0002751_abnormal_autonomic_nervous0.98605864
91MP0002088_abnormal_embryonic_growth/wei0.98085061
92MP0000858_altered_metastatic_potential0.96906644
93MP0001119_abnormal_female_reproductive0.96895359
94MP0003763_abnormal_thymus_physiology0.96750567
95MP0005389_reproductive_system_phenotype0.96031522
96MP0005621_abnormal_cell_physiology0.94826684
97MP0001243_abnormal_dermal_layer0.94011481
98MP0002084_abnormal_developmental_patter0.93771900
99MP0000003_abnormal_adipose_tissue0.93070872
100MP0002638_abnormal_pupillary_reflex0.93065418
101MP0002163_abnormal_gland_morphology0.93028829
102MP0002429_abnormal_blood_cell0.91015729
103MP0008874_decreased_physiological_sensi0.90600866
104MP0000653_abnormal_sex_gland0.90066009
105MP0009333_abnormal_splenocyte_physiolog0.89418936
106MP0005623_abnormal_meninges_morphology0.88705395
107MP0005330_cardiomyopathy0.87470492
108MP0004147_increased_porphyrin_level0.86822842
109MP0006035_abnormal_mitochondrial_morpho0.86756532
110MP0005379_endocrine/exocrine_gland_phen0.86372503
111MP0000465_gastrointestinal_hemorrhage0.86304024
112MP0003787_abnormal_imprinting0.86179537
113MP0002877_abnormal_melanocyte_morpholog0.83781743
114MP0005075_abnormal_melanosome_morpholog0.83502083
115MP0005666_abnormal_adipose_tissue0.83499572
116MP0000759_abnormal_skeletal_muscle0.83313508
117MP0000604_amyloidosis0.83277137
118MP0003436_decreased_susceptibility_to0.82671494
119MP0000537_abnormal_urethra_morphology0.82508808
120MP0004197_abnormal_fetal_growth/weight/0.81402033
121MP0000049_abnormal_middle_ear0.80905353
122MP0005084_abnormal_gallbladder_morpholo0.80433694
123MP0001905_abnormal_dopamine_level0.80194302
124MP0010307_abnormal_tumor_latency0.79613358
125MP0009931_abnormal_skin_appearance0.79424638
126MP0001944_abnormal_pancreas_morphology0.78772472
127MP0000703_abnormal_thymus_morphology0.78132981
128MP0002086_abnormal_extraembryonic_tissu0.77175454
129MP0005174_abnormal_tail_pigmentation0.76698131
130MP0003453_abnormal_keratinocyte_physiol0.76056720
131MP0003172_abnormal_lysosome_physiology0.75928776
132MP0004133_heterotaxia0.75767943
133MP0004264_abnormal_extraembryonic_tissu0.75632019
134MP0005646_abnormal_pituitary_gland0.75097076
135MP0001929_abnormal_gametogenesis0.74914585
136MP0001919_abnormal_reproductive_system0.74804913
137MP0003183_abnormal_peptide_metabolism0.74727269
138MP0002398_abnormal_bone_marrow0.74605565
139MP0002653_abnormal_ependyma_morphology0.73812941
140MP0003942_abnormal_urinary_system0.73254520
141MP0002722_abnormal_immune_system0.73042172
142MP0000689_abnormal_spleen_morphology0.72757575
143MP0005266_abnormal_metabolism0.72242925
144MP0001986_abnormal_taste_sensitivity0.71943648
145MP0005384_cellular_phenotype0.71864561
146MP0010352_gastrointestinal_tract_polyps0.71537110
147MP0005375_adipose_tissue_phenotype0.68983005
148MP0005584_abnormal_enzyme/coenzyme_acti0.68963486
149MP0004510_myositis0.67946425
150MP0009672_abnormal_birth_weight0.67897209
151MP0003943_abnormal_hepatobiliary_system0.67887966
152MP0010771_integument_phenotype0.67433303
153MP0003221_abnormal_cardiomyocyte_apopto0.64618460
154MP0002060_abnormal_skin_morphology0.64134070
155MP0000627_abnormal_mammary_gland0.62467747
156MP0005000_abnormal_immune_tolerance0.62107586
157MP0001216_abnormal_epidermal_layer0.61512545
158MP0009763_increased_sensitivity_to0.60081046

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.73778166
2Reticulocytopenia (HP:0001896)4.50323430
3Birth length less than 3rd percentile (HP:0003561)4.14657869
4Abnormal number of erythroid precursors (HP:0012131)4.12110871
5Abnormality of cells of the erythroid lineage (HP:0012130)4.09695946
6Oral leukoplakia (HP:0002745)3.99994669
7Type I transferrin isoform profile (HP:0003642)3.96370328
8Vertebral compression fractures (HP:0002953)3.58421826
9Abnormal gallbladder physiology (HP:0012438)3.55676127
10Cholecystitis (HP:0001082)3.55676127
11Abnormality of the anterior horn cell (HP:0006802)3.50994393
12Degeneration of anterior horn cells (HP:0002398)3.50994393
1311 pairs of ribs (HP:0000878)3.44354668
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33804774
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33804774
16J-shaped sella turcica (HP:0002680)3.27709732
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.21281548
18Abnormal protein N-linked glycosylation (HP:0012347)3.21281548
19Abnormal protein glycosylation (HP:0012346)3.21281548
20Abnormal glycosylation (HP:0012345)3.21281548
21Reduced antithrombin III activity (HP:0001976)3.17944953
22Hyperacusis (HP:0010780)3.10052388
23Abnormality of liposaccharide metabolism (HP:0010968)3.07175943
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.07175943
25Abnormality of glycolipid metabolism (HP:0010969)3.07175943
26Colon cancer (HP:0003003)3.05829080
27Hepatocellular necrosis (HP:0001404)3.05663526
28Achilles tendon contracture (HP:0001771)3.02691226
29Thrombocytosis (HP:0001894)3.02247985
30Ragged-red muscle fibers (HP:0003200)3.01644839
31Petechiae (HP:0000967)3.00047934
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97336227
33Rough bone trabeculation (HP:0100670)2.95898814
34Microretrognathia (HP:0000308)2.94436142
35Mitochondrial inheritance (HP:0001427)2.84787253
36Hepatic necrosis (HP:0002605)2.82678067
37Increased cerebral lipofuscin (HP:0011813)2.82432191
38Breast hypoplasia (HP:0003187)2.82338790
39Distal lower limb amyotrophy (HP:0008944)2.77453923
40Progressive muscle weakness (HP:0003323)2.76783687
41Insomnia (HP:0100785)2.76253548
42Increased CSF lactate (HP:0002490)2.75506760
43Abnormality of the Achilles tendon (HP:0005109)2.72175187
44Chromsome breakage (HP:0040012)2.71935936
45Pallor (HP:0000980)2.71125921
46Increased hepatocellular lipid droplets (HP:0006565)2.70983639
47Premature graying of hair (HP:0002216)2.70932979
48Distal lower limb muscle weakness (HP:0009053)2.70269356
49Abnormal mitochondria in muscle tissue (HP:0008316)2.68944232
50Reticulocytosis (HP:0001923)2.66596900
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.65108501
52Macrocytic anemia (HP:0001972)2.64934023
53Hypertensive crisis (HP:0100735)2.64915077
54Increased serum lactate (HP:0002151)2.64910911
55Acute necrotizing encephalopathy (HP:0006965)2.63685726
56Hepatosplenomegaly (HP:0001433)2.62195022
57Purpura (HP:0000979)2.57096694
58Increased intramyocellular lipid droplets (HP:0012240)2.52315934
59Selective tooth agenesis (HP:0001592)2.51410223
60Lipid accumulation in hepatocytes (HP:0006561)2.48580589
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48401593
62Pancytopenia (HP:0001876)2.44663495
63Patellar aplasia (HP:0006443)2.44350864
64Growth hormone excess (HP:0000845)2.42669599
65Abnormality of the preputium (HP:0100587)2.41762388
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41161302
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41092163
68Fasciculations (HP:0002380)2.39648441
69Slender long bone (HP:0003100)2.38873880
70Abnormality of reticulocytes (HP:0004312)2.34114308
71Upper limb muscle weakness (HP:0003484)2.33601304
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.33513905
73Abnormality of the ileum (HP:0001549)2.32441991
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32343861
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.32007450
76Neoplasm of the pancreas (HP:0002894)2.30788478
77Aplasia/Hypoplasia of the patella (HP:0006498)2.30171596
78Meckel diverticulum (HP:0002245)2.29606087
79Myelodysplasia (HP:0002863)2.28151290
80Agnosia (HP:0010524)2.27512489
81Bone marrow hypocellularity (HP:0005528)2.27204842
82Medulloblastoma (HP:0002885)2.22657665
83Hyperthyroidism (HP:0000836)2.22210159
84Dysostosis multiplex (HP:0000943)2.21772646
85Missing ribs (HP:0000921)2.21733662
86Abnormality of the umbilical cord (HP:0010881)2.20419445
87Cholelithiasis (HP:0001081)2.20178973
88Abnormality of the heme biosynthetic pathway (HP:0010472)2.19721935
89Abnormality of chromosome stability (HP:0003220)2.17872709
90Back pain (HP:0003418)2.17635966
91Exertional dyspnea (HP:0002875)2.16963153
92Ependymoma (HP:0002888)2.16138132
93Trismus (HP:0000211)2.15840177
94Cerebral palsy (HP:0100021)2.14536945
95Carpal bone hypoplasia (HP:0001498)2.14456593
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.13765555
97Acute encephalopathy (HP:0006846)2.12898560
98Respiratory difficulties (HP:0002880)2.12182732
99Abnormal lung lobation (HP:0002101)2.11577706
100Prolonged neonatal jaundice (HP:0006579)2.11536807
101Vacuolated lymphocytes (HP:0001922)2.11403154
102Exercise intolerance (HP:0003546)2.11263471
103Increased muscle lipid content (HP:0009058)2.10715398
104Optic nerve coloboma (HP:0000588)2.08535821
105Hypoplasia of the pons (HP:0012110)2.07132950
106Absent thumb (HP:0009777)2.06006876
107Premature rupture of membranes (HP:0001788)2.05989436
108Increased serum ferritin (HP:0003281)2.05378365
109Myoglobinuria (HP:0002913)2.04493093
110Orthostatic hypotension (HP:0001278)2.03894997
111Microvesicular hepatic steatosis (HP:0001414)2.03462359
112Insidious onset (HP:0003587)2.03419070
113Termporal pattern (HP:0011008)2.03419070
114Abnormality of the tricuspid valve (HP:0001702)2.02392007
115Nephroblastoma (Wilms tumor) (HP:0002667)1.99784618
116Lactic acidosis (HP:0003128)1.99730065
117Broad distal phalanx of finger (HP:0009836)1.97643418
118Rhabdomyolysis (HP:0003201)1.97437718
119Microglossia (HP:0000171)1.97425152
120Abnormal trabecular bone morphology (HP:0100671)1.96849527
121Increased serum pyruvate (HP:0003542)1.95353141
122Abnormality of glycolysis (HP:0004366)1.95353141
123Testicular atrophy (HP:0000029)1.92844703
124Embryonal renal neoplasm (HP:0011794)1.92021099
125Multiple enchondromatosis (HP:0005701)1.91429201
126Duodenal stenosis (HP:0100867)1.91076464
127Small intestinal stenosis (HP:0012848)1.91076464
1283-Methylglutaconic aciduria (HP:0003535)1.91049255
129Unsteady gait (HP:0002317)1.90004299
130Cellular immunodeficiency (HP:0005374)1.88833649
131Secondary amenorrhea (HP:0000869)1.88146102
132IgM deficiency (HP:0002850)1.87914828
133Loss of speech (HP:0002371)1.87132712
134Progressive macrocephaly (HP:0004481)1.86840025
135Diminished motivation (HP:0000745)1.86166593
136Tracheoesophageal fistula (HP:0002575)1.85476143
137Impaired platelet aggregation (HP:0003540)1.85210391
138Abnormal platelet function (HP:0011869)1.85210391
139Entropion (HP:0000621)1.83937280
140Cerebral hypomyelination (HP:0006808)1.83329196
141Horseshoe kidney (HP:0000085)1.83321396
142Lower limb amyotrophy (HP:0007210)1.83147438
143Emotional lability (HP:0000712)1.82413046
144Patellar dislocation (HP:0002999)1.81166166
145Hyperparathyroidism (HP:0000843)1.80785092
146Increased mean platelet volume (HP:0011877)1.80295847
147Neuroblastoma (HP:0003006)1.79857776
148Primitive neuroectodermal tumor (HP:0030065)1.79857776
149Neuroblastic tumors (HP:0004376)1.79857776
150Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.79857776
151Abnormality of lateral ventricle (HP:0030047)1.79764471
152Sloping forehead (HP:0000340)1.78975055
153Seborrheic dermatitis (HP:0001051)1.78559609
154Renal Fanconi syndrome (HP:0001994)1.78169196
155Myopathic facies (HP:0002058)1.78159347
156Prolonged bleeding time (HP:0003010)1.78056791
157Abnormality of the distal phalanges of the toes (HP:0010182)1.78044978
158Abnormality of the pons (HP:0007361)1.76897145
159Menorrhagia (HP:0000132)1.76230825
160Facial cleft (HP:0002006)1.75644715
161Muscle stiffness (HP:0003552)1.75099281
162Pendular nystagmus (HP:0012043)1.74873876
163Upper limb amyotrophy (HP:0009129)1.74684305
164Distal upper limb amyotrophy (HP:0007149)1.74684305
165Hypokinesia (HP:0002375)1.74307344
166Acute lymphatic leukemia (HP:0006721)1.74260553
167Abnormal umbilical cord blood vessels (HP:0011403)1.74206137
168Single umbilical artery (HP:0001195)1.74206137
169Abnormality of the fetal cardiovascular system (HP:0010948)1.74206137
170Muscle fiber atrophy (HP:0100295)1.74161886
171Abnormal gallbladder morphology (HP:0012437)1.74013652
172Generalized amyotrophy (HP:0003700)1.72982880
173Overriding aorta (HP:0002623)1.72049422
174Spinal rigidity (HP:0003306)1.71951697
175Shoulder girdle muscle weakness (HP:0003547)1.70830416
176Progressive neurologic deterioration (HP:0002344)1.68658963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.07254314
2CDC73.76613951
3WEE13.64941688
4PASK3.52591804
5STK163.48926801
6VRK23.37722825
7EIF2AK13.02448594
8ACVR1B2.87544198
9IRAK32.84092515
10VRK12.53027412
11TSSK62.40594827
12TRIB32.37627553
13EIF2AK32.32473926
14BRSK22.26995932
15NEK12.23387626
16ERN12.16743663
17CDK82.12467939
18SCYL22.11357622
19CCNB12.02741110
20SMG12.01343600
21FLT31.93562093
22TGFBR11.80838607
23BRSK11.80585975
24SRPK11.76074032
25TESK21.69212013
26DYRK31.68559222
27NME21.66812583
28MKNK11.65596349
29CDK71.50634726
30NEK21.50446587
31PLK11.48685088
32PRPF4B1.46339621
33BCKDK1.38457582
34ATR1.37680161
35MAP3K121.36949962
36PLK41.35818386
37TTK1.34262661
38BRAF1.32633084
39PIM21.31952055
40TLK11.27562204
41KDR1.24375423
42RPS6KB21.22087075
43RPS6KA41.21374507
44AURKB1.21327512
45PLK31.20646698
46CDK191.11542441
47DAPK11.10349357
48PAK41.09009180
49TESK11.05745843
50EPHA21.01893742
51CSNK1G31.00318775
52CDK140.99777998
53MKNK20.97314337
54AURKA0.97313799
55ABL20.96151690
56CHEK20.88623702
57CDK150.87029206
58YES10.86499142
59ICK0.86086086
60SIK10.84510581
61SIK30.81945539
62TBK10.81645043
63LIMK10.79390254
64KIT0.78837296
65BMX0.77267450
66TTN0.76857563
67TEC0.75771105
68CAMKK20.73950127
69DAPK30.71552535
70CDK40.70717956
71MAP3K110.70204102
72ERBB30.69483660
73MAP2K30.68587403
74CHEK10.68282722
75CSNK2A10.68260220
76LMTK20.67054722
77DYRK20.66062046
78MAPKAPK30.64268123
79BTK0.63638672
80CSNK2A20.61684079
81CAMK2G0.61180223
82CSNK1A1L0.59173005
83NME10.57694079
84PBK0.57339668
85TAOK10.57148354
86MYLK0.56178094
87MAP3K80.56005455
88EEF2K0.52717279
89CDK20.51699133
90CSF1R0.51502727
91UHMK10.50709776
92CSNK1G20.50379208
93PAK10.49926394
94NTRK10.49210652
95MAP2K20.49164233
96MOS0.48084359
97ILK0.46834561
98PAK20.45960204
99ATM0.45844214
100PTK20.45670544
101EIF2AK20.45509295
102BMPR1B0.44854924
103AKT20.44186254
104PRKCI0.43406905
105PIK3CG0.43401292
106WNK30.41371787
107PKN20.40978262
108CAMK2B0.39020095
109LRRK20.38954247
110NEK90.38127748
111ARAF0.37160879
112ADRBK20.36288106
113PIM10.35609657
114MAPK130.34570758
115MAP3K10.34512128
116PTK60.34352149
117TAOK20.34191766
118CDK10.34162729
119MAPKAPK20.32112230
120ZAP700.31500724
121RAF10.31098961
122CLK10.30873783
123MINK10.30779466
124CAMK2D0.30752541
125CDK180.30671622
126RPS6KA50.30275273
127MAP2K60.29139983
128IRAK40.28861660
129CDK11A0.28853911
130LATS20.28586647
131ZAK0.28466150
132IRAK20.28002115
133CSNK1G10.27721563
134HIPK20.27508955
135MAPK110.27046445
136CAMKK10.26927605
137MATK0.26758636
138RPS6KC10.26472940
139RPS6KL10.26472940
140MAP2K70.26407813
141MAPKAPK50.26323881
142TRIM280.25756393
143RIPK40.25587399

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.71859461
2Mismatch repair_Homo sapiens_hsa034304.66734425
3Ribosome_Homo sapiens_hsa030103.82176891
4Proteasome_Homo sapiens_hsa030503.68094640
5Base excision repair_Homo sapiens_hsa034103.39457857
6Homologous recombination_Homo sapiens_hsa034403.21696065
7Spliceosome_Homo sapiens_hsa030403.12371640
8RNA polymerase_Homo sapiens_hsa030203.03269504
9Nucleotide excision repair_Homo sapiens_hsa034202.98426125
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93139904
11Pyrimidine metabolism_Homo sapiens_hsa002402.75547849
12Protein export_Homo sapiens_hsa030602.59322142
13* RNA transport_Homo sapiens_hsa030132.48475251
14Cell cycle_Homo sapiens_hsa041102.46269347
15Fatty acid elongation_Homo sapiens_hsa000622.44847011
16One carbon pool by folate_Homo sapiens_hsa006702.36771390
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27487128
18RNA degradation_Homo sapiens_hsa030181.93496921
19Fanconi anemia pathway_Homo sapiens_hsa034601.83992693
20Non-homologous end-joining_Homo sapiens_hsa034501.80366479
21Basal transcription factors_Homo sapiens_hsa030221.74945693
22Purine metabolism_Homo sapiens_hsa002301.56808336
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55022566
24Lysosome_Homo sapiens_hsa041421.47817357
25Parkinsons disease_Homo sapiens_hsa050121.37551142
26N-Glycan biosynthesis_Homo sapiens_hsa005101.30992674
27Folate biosynthesis_Homo sapiens_hsa007901.29452542
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25577077
29p53 signaling pathway_Homo sapiens_hsa041151.21225670
30Synaptic vesicle cycle_Homo sapiens_hsa047211.16847511
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.16808862
32Oxidative phosphorylation_Homo sapiens_hsa001901.15429576
33mRNA surveillance pathway_Homo sapiens_hsa030151.14729944
34Salmonella infection_Homo sapiens_hsa051321.11460461
35Huntingtons disease_Homo sapiens_hsa050161.08669581
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06158878
37Pancreatic cancer_Homo sapiens_hsa052120.98840626
38Thyroid cancer_Homo sapiens_hsa052160.96325013
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92317475
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90687044
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89386206
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88712949
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.86884976
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.85883209
45Epstein-Barr virus infection_Homo sapiens_hsa051690.84792905
46Oocyte meiosis_Homo sapiens_hsa041140.83405746
47Galactose metabolism_Homo sapiens_hsa000520.83126795
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82436811
49Chronic myeloid leukemia_Homo sapiens_hsa052200.81453618
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.79970138
51Biosynthesis of amino acids_Homo sapiens_hsa012300.75931448
52Pentose phosphate pathway_Homo sapiens_hsa000300.75522500
53Selenocompound metabolism_Homo sapiens_hsa004500.75232154
54Endocytosis_Homo sapiens_hsa041440.74400291
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73493272
56Antigen processing and presentation_Homo sapiens_hsa046120.71725045
57Systemic lupus erythematosus_Homo sapiens_hsa053220.70164911
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68081096
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66913140
60VEGF signaling pathway_Homo sapiens_hsa043700.66794352
61Prion diseases_Homo sapiens_hsa050200.64165830
62Legionellosis_Homo sapiens_hsa051340.62774874
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62334385
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62157187
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61074381
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60832585
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59275543
68Alcoholism_Homo sapiens_hsa050340.58142817
69Viral carcinogenesis_Homo sapiens_hsa052030.56738385
70Sulfur relay system_Homo sapiens_hsa041220.55826749
71Herpes simplex infection_Homo sapiens_hsa051680.55307023
72Alzheimers disease_Homo sapiens_hsa050100.54227739
73Carbon metabolism_Homo sapiens_hsa012000.48446427
74Viral myocarditis_Homo sapiens_hsa054160.47694925
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47535317
76Collecting duct acid secretion_Homo sapiens_hsa049660.47370234
77Glutathione metabolism_Homo sapiens_hsa004800.44250565
78Vibrio cholerae infection_Homo sapiens_hsa051100.42604766
79HTLV-I infection_Homo sapiens_hsa051660.42264504
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41639281
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40979944
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39792695
83Fructose and mannose metabolism_Homo sapiens_hsa000510.38356975
84Metabolic pathways_Homo sapiens_hsa011000.35843672
85Rheumatoid arthritis_Homo sapiens_hsa053230.34707777
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34499208
87Platelet activation_Homo sapiens_hsa046110.33639800
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32820028
89Bladder cancer_Homo sapiens_hsa052190.32267396
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31650910
91Other glycan degradation_Homo sapiens_hsa005110.30994476
92Vitamin B6 metabolism_Homo sapiens_hsa007500.27103351
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26304010
94Colorectal cancer_Homo sapiens_hsa052100.25630753
95Glioma_Homo sapiens_hsa052140.24653698
96Fatty acid metabolism_Homo sapiens_hsa012120.24478142
97Steroid biosynthesis_Homo sapiens_hsa001000.24124612
98Cardiac muscle contraction_Homo sapiens_hsa042600.24050203
99Shigellosis_Homo sapiens_hsa051310.20852617
100Renin-angiotensin system_Homo sapiens_hsa046140.20215341
101Pyruvate metabolism_Homo sapiens_hsa006200.19639509
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19552585
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18994175
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16628988
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15388532
106Arachidonic acid metabolism_Homo sapiens_hsa005900.14909859
107Hepatitis B_Homo sapiens_hsa051610.13874869
108Apoptosis_Homo sapiens_hsa042100.13533316
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13323416
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12140167
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10833048
112Type I diabetes mellitus_Homo sapiens_hsa049400.08377867
113Regulation of autophagy_Homo sapiens_hsa041400.08293375
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.06086040
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03223881
116Non-small cell lung cancer_Homo sapiens_hsa052230.02166478
117Phagosome_Homo sapiens_hsa041450.01603619
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00821497
119Acute myeloid leukemia_Homo sapiens_hsa052210.00260803
120Small cell lung cancer_Homo sapiens_hsa052220.00107525
121Pathways in cancer_Homo sapiens_hsa05200-0.0621733
122MicroRNAs in cancer_Homo sapiens_hsa05206-0.0601333
123Influenza A_Homo sapiens_hsa05164-0.0581464
124TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0480001
125Measles_Homo sapiens_hsa05162-0.0421233
126HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0267564
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0146760

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