SUN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.37763806
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.88960753
3hemidesmosome assembly (GO:0031581)3.78689851
4cytoskeletal anchoring at plasma membrane (GO:0007016)3.69754066
5regulation of spindle organization (GO:0090224)3.64554004
6intestinal epithelial cell development (GO:0060576)3.59942659
7purine nucleobase biosynthetic process (GO:0009113)3.49398375
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.49241703
9spindle assembly involved in mitosis (GO:0090307)3.40688602
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37910472
11nucleobase biosynthetic process (GO:0046112)3.32078180
12nuclear pore organization (GO:0006999)3.27365972
13mitotic metaphase plate congression (GO:0007080)3.27274857
14ribosome assembly (GO:0042255)3.26968445
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26293041
16epithelial cell-cell adhesion (GO:0090136)3.22523564
17protein localization to kinetochore (GO:0034501)3.22072893
18adherens junction assembly (GO:0034333)3.19649264
19mitotic sister chromatid segregation (GO:0000070)3.19114618
20lung-associated mesenchyme development (GO:0060484)3.15743464
21cell-substrate junction assembly (GO:0007044)3.13112834
22focal adhesion assembly (GO:0048041)3.12720713
23cell-substrate adherens junction assembly (GO:0007045)3.12720713
24regulation of mitotic spindle organization (GO:0060236)3.12330155
25skin morphogenesis (GO:0043589)3.11783973
26semaphorin-plexin signaling pathway (GO:0071526)3.09606259
27regulation of centrosome cycle (GO:0046605)3.06363292
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06187314
29peptidyl-threonine dephosphorylation (GO:0035970)3.03348451
30positive regulation of chromosome segregation (GO:0051984)3.03119506
31microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.02252428
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98847989
33histone-serine phosphorylation (GO:0035404)2.98422179
34positive regulation of synapse maturation (GO:0090129)2.95393203
35vitamin transmembrane transport (GO:0035461)2.94030584
36synaptonemal complex assembly (GO:0007130)2.92339455
37mitotic nuclear envelope disassembly (GO:0007077)2.92256166
38sister chromatid segregation (GO:0000819)2.91706925
39ribosome biogenesis (GO:0042254)2.91283623
40nuclear envelope disassembly (GO:0051081)2.90513314
41membrane disassembly (GO:0030397)2.90513314
42protein retention in ER lumen (GO:0006621)2.88294398
43nuclear pore complex assembly (GO:0051292)2.87089370
44regulation of chromosome segregation (GO:0051983)2.86603214
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85541789
46regulation of centriole replication (GO:0046599)2.84766899
47DNA replication checkpoint (GO:0000076)2.82279247
48regulation of translational termination (GO:0006449)2.81485243
49peptidyl-lysine dimethylation (GO:0018027)2.77623927
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77350767
51negative regulation of chromosome segregation (GO:0051985)2.74388854
52synaptonemal complex organization (GO:0070193)2.73433837
53regulation of glucose import in response to insulin stimulus (GO:2001273)2.71856888
54histone H4-K8 acetylation (GO:0043982)2.71044054
55histone H4-K5 acetylation (GO:0043981)2.71044054
56DNA replication-dependent nucleosome organization (GO:0034723)2.70518288
57DNA replication-dependent nucleosome assembly (GO:0006335)2.70518288
58axonemal dynein complex assembly (GO:0070286)2.69699015
59establishment of apical/basal cell polarity (GO:0035089)2.68391236
60regulation of establishment of planar polarity (GO:0090175)2.66507709
61motile cilium assembly (GO:0044458)2.66436531
62spindle checkpoint (GO:0031577)2.64685613
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.63867885
64negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63867885
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63867885
66negative regulation of sister chromatid segregation (GO:0033046)2.63867885
67mitotic spindle checkpoint (GO:0071174)2.63187178
68mitotic spindle assembly checkpoint (GO:0007094)2.61675523
69regulation of chromatin binding (GO:0035561)2.61434921
70regulation of hippo signaling (GO:0035330)2.61298368
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58890147
72negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.58096651
73endothelial cell chemotaxis (GO:0035767)2.57156384
74metaphase plate congression (GO:0051310)2.57033302
75insulin-like growth factor receptor signaling pathway (GO:0048009)2.56581527
76* nuclear envelope organization (GO:0006998)2.56510082
77negative regulation of chondrocyte differentiation (GO:0032331)2.54952212
78labyrinthine layer development (GO:0060711)2.54838249
79spindle assembly checkpoint (GO:0071173)2.54819505
80mitotic chromosome condensation (GO:0007076)2.54327405
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54275351
82monoubiquitinated protein deubiquitination (GO:0035520)2.53950557
83mitotic spindle organization (GO:0007052)2.53086337
84sarcomere organization (GO:0045214)2.52572459
85protein localization to chromosome, centromeric region (GO:0071459)2.51767041
86synaptic vesicle docking involved in exocytosis (GO:0016081)2.50993631
87formation of translation preinitiation complex (GO:0001731)2.50686569
88GMP metabolic process (GO:0046037)2.50523260
89apical protein localization (GO:0045176)2.50363691
90protein K6-linked ubiquitination (GO:0085020)2.49425302
91regulation of gene silencing by RNA (GO:0060966)2.48689823
92regulation of posttranscriptional gene silencing (GO:0060147)2.48689823
93regulation of gene silencing by miRNA (GO:0060964)2.48689823
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.47326887
95surfactant homeostasis (GO:0043129)2.46028836
96muscle filament sliding (GO:0030049)2.45416216
97actin-myosin filament sliding (GO:0033275)2.45416216
98negative regulation of histone methylation (GO:0031061)2.44884634
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.44832464
100histone H2A monoubiquitination (GO:0035518)2.44775909
101regulation of mitotic sister chromatid separation (GO:0010965)2.43415227
102regulation of mitotic sister chromatid segregation (GO:0033047)2.43415227
103regulation of sister chromatid segregation (GO:0033045)2.43415227
104histone phosphorylation (GO:0016572)2.42113443
105regulation of histone H3-K27 methylation (GO:0061085)2.41954239
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.41418653
107attachment of spindle microtubules to kinetochore (GO:0008608)2.41016193
108notochord development (GO:0030903)2.40948949
109folic acid metabolic process (GO:0046655)2.40295864
110myoblast fusion (GO:0007520)2.39465572
111basement membrane organization (GO:0071711)2.39256183
112lung epithelium development (GO:0060428)2.39253574
113folic acid transport (GO:0015884)2.39214908
114establishment of planar polarity (GO:0001736)2.38515999
115establishment of tissue polarity (GO:0007164)2.38515999
116establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38094482
117establishment or maintenance of bipolar cell polarity (GO:0061245)2.38094482
118actomyosin structure organization (GO:0031032)2.37999967
119CDP-diacylglycerol metabolic process (GO:0046341)2.37353898
120gene silencing by RNA (GO:0031047)2.37089315
121asymmetric protein localization (GO:0008105)2.36428792
122camera-type eye morphogenesis (GO:0048593)2.36383572
123regulation of RNA export from nucleus (GO:0046831)2.36050306
124negative regulation of inclusion body assembly (GO:0090084)2.35697617
125regulation of centrosome duplication (GO:0010824)2.35224569
126Golgi transport vesicle coating (GO:0048200)2.35150349
127COPI coating of Golgi vesicle (GO:0048205)2.35150349
128mitotic G1 DNA damage checkpoint (GO:0031571)2.34989589
129blastocyst development (GO:0001824)2.34494349
130regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.34439657
131adherens junction organization (GO:0034332)2.33918431
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33312870
133protein localization to chromosome (GO:0034502)2.33081651
134embryonic retina morphogenesis in camera-type eye (GO:0060059)2.32852839
135hippo signaling (GO:0035329)2.32165449
136spliceosomal tri-snRNP complex assembly (GO:0000244)2.32049019
137negative regulation of meiosis (GO:0045835)2.31308221
138non-canonical Wnt signaling pathway (GO:0035567)2.30904888
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.30347895
140glomerular epithelial cell development (GO:0072310)2.28335633
141histone H3-K9 demethylation (GO:0033169)2.28101214
142plasma membrane repair (GO:0001778)2.27794024
143regulation of cardioblast differentiation (GO:0051890)2.26321943
144paraxial mesoderm development (GO:0048339)2.25954373
145activation of Rac GTPase activity (GO:0032863)2.25870965
146cell communication involved in cardiac conduction (GO:0086065)2.24261747
147negative regulation of fatty acid transport (GO:2000192)2.23461776
148COPII vesicle coating (GO:0048208)2.22996080
149regulation of translation in response to stress (GO:0043555)2.22670953
150regulation of water loss via skin (GO:0033561)2.22471360
151cardiac myofibril assembly (GO:0055003)2.22049292
152cochlea morphogenesis (GO:0090103)2.21718099
153autophagic vacuole assembly (GO:0000045)2.20926697
154DNA replication initiation (GO:0006270)2.20163575
155positive regulation of smoothened signaling pathway (GO:0045880)2.19858039
156actin filament depolymerization (GO:0030042)2.19482076
157meiosis I (GO:0007127)2.19443654
158actin-mediated cell contraction (GO:0070252)2.18826840
159negative regulation of proteasomal protein catabolic process (GO:1901799)2.18771783
160NADH metabolic process (GO:0006734)2.18526383
161vesicle coating (GO:0006901)2.17864046
162cell communication by electrical coupling (GO:0010644)2.17189819
163negative regulation of cell size (GO:0045792)2.16725842
164activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.16624345
165establishment of monopolar cell polarity (GO:0061162)2.15296404
166establishment or maintenance of monopolar cell polarity (GO:0061339)2.15296404
167atrioventricular valve morphogenesis (GO:0003181)2.14642519
168cell adhesion mediated by integrin (GO:0033627)2.14318756
169ventricular cardiac muscle cell action potential (GO:0086005)2.13713599
170ear development (GO:0043583)2.13057476
171syncytium formation by plasma membrane fusion (GO:0000768)2.12938736
172regulation of NFAT protein import into nucleus (GO:0051532)2.11911341
173convergent extension (GO:0060026)2.11294126
174muscle cell migration (GO:0014812)2.09561768
175eye morphogenesis (GO:0048592)2.09164831
176negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.08459630
177myofibril assembly (GO:0030239)2.08235266
178cell junction assembly (GO:0034329)2.06883955
179multicellular organismal water homeostasis (GO:0050891)2.06626815
180stress granule assembly (GO:0034063)2.06517039
181endothelial cell morphogenesis (GO:0001886)2.06498450
182regulation of axon extension involved in axon guidance (GO:0048841)2.06164837
183actin filament-based movement (GO:0030048)2.05846432
184cilium or flagellum-dependent cell motility (GO:0001539)2.05606175
185regulation of transforming growth factor beta2 production (GO:0032909)2.04892198
186positive regulation of nuclease activity (GO:0032075)2.04795794
187cardiac muscle contraction (GO:0060048)2.04762121
188gap junction assembly (GO:0016264)2.03585450
189chemical homeostasis within a tissue (GO:0048875)2.03177348
190cell-cell junction assembly (GO:0007043)2.03067715
191neuromuscular junction development (GO:0007528)2.02496083
192response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.01349042
193negative regulation of catenin import into nucleus (GO:0035414)1.99598710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.26523485
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46391660
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06339383
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.05244790
5ZNF263_19887448_ChIP-Seq_K562_Human2.89963596
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88847009
7CLOCK_20551151_ChIP-Seq_293T_Human2.81190621
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75276167
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71673624
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.70135194
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.62341140
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57923248
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.51243925
14AR_21909140_ChIP-Seq_LNCAP_Human2.47042423
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37887817
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36961534
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30370188
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30370188
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30370188
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23240509
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18912318
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.14668512
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.05967804
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04396953
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00708432
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99443219
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94573513
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.94520440
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.93837603
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93786529
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.91706901
32RACK7_27058665_Chip-Seq_MCF-7_Human1.90522441
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89733311
34* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.89716439
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.87076978
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85002190
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83871305
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79977024
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79602589
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78232104
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72028129
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69937096
43KDM2B_26808549_Chip-Seq_K562_Human1.69634174
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68208622
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68025688
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.67532091
47* TBX20_22080862_ChIP-Seq_HEART_Mouse1.67532091
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67240279
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67166244
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64822046
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.63422807
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62204848
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61848569
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.61641783
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.60469202
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59198308
57* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58182595
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58145957
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54084124
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53143860
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52196770
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51305977
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50566219
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48475414
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47509314
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46665700
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.45821069
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45041215
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43311279
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42799354
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42648247
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42437777
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42437777
74GATA1_22025678_ChIP-Seq_K562_Human1.42368545
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.42279132
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41324677
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40340597
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40068352
79LXR_22292898_ChIP-Seq_THP-1_Human1.38827642
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38763145
81* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38655594
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.38477076
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37514523
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37348384
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36152388
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35942418
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.35366166
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34931721
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34398813
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33980509
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31467301
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30206253
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.29659555
94DROSHA_22980978_ChIP-Seq_HELA_Human1.29361416
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.29007790
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27991228
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26911439
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25753903
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25002289
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24882026
101* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24404379
102* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22439685
103XRN2_22483619_ChIP-Seq_HELA_Human1.21560982
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21267581
105AHR_22903824_ChIP-Seq_MCF-7_Human1.20995028
106GABP_19822575_ChIP-Seq_HepG2_Human1.19969978
107KDM5A_27292631_Chip-Seq_BREAST_Human1.19863885
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19536506
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19441861
110CREB1_26743006_Chip-Seq_LNCaP_Human1.18906038
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18780107
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18097658
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17731418
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.17341653
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17319001
116SMC4_20622854_ChIP-Seq_HELA_Human1.15914666
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15344413
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15185233
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14964975
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13844138
121KLF5_25053715_ChIP-Seq_YYC3_Human1.13088989
122* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12783561
123* KAP1_27257070_Chip-Seq_ESCs_Mouse1.12491178
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12209511
125TP53_23651856_ChIP-Seq_MEFs_Mouse1.11923893
126ATF3_27146783_Chip-Seq_COLON_Human1.11854261
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11654368
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.11578558
129* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11500756
130TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11212765
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11094343
132E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10652565
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09787474
134TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.07143017
135TP53_22127205_ChIP-Seq_IMR90_Human1.06648154
136FOXA2_19822575_ChIP-Seq_HepG2_Human1.06507705
137EST1_17652178_ChIP-ChIP_JURKAT_Human1.06274267
138EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05975560
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05510884
140* TCF7_22412390_ChIP-Seq_EML_Mouse1.05143948
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04683191
142UBF1/2_26484160_Chip-Seq_HMECs_Human1.04403950
143* RARB_27405468_Chip-Seq_BRAIN_Mouse1.03851905
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03695104
145ZNF274_21170338_ChIP-Seq_K562_Hela1.02901968
146ISL1_27105846_Chip-Seq_CPCs_Mouse1.01349523
147CIITA_25753668_ChIP-Seq_RAJI_Human1.01332462
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01197942
149CDX2_20551321_ChIP-Seq_CACO-2_Human1.00764003
150SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00731344
151POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00670128
152RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00034271
153EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00034271
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99823394
155ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99611269
156DCP1A_22483619_ChIP-Seq_HELA_Human0.99440034
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99073426
158* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98594318
159POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98315977
160CTCF_27219007_Chip-Seq_Bcells_Human0.97340257
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97104741
162NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96503555
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96280672
164PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95930753
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95108679
166VDR_23849224_ChIP-Seq_CD4+_Human0.95052763
167KDM2B_26808549_Chip-Seq_DND41_Human0.94214968
168HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94111677
169P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93271411
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93190983
171CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92941583
172YY1_21170310_ChIP-Seq_MESCs_Mouse0.92120341
173PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91875702
174CHD1_26751641_Chip-Seq_LNCaP_Human0.91371070
175RUNX1_27514584_Chip-Seq_MCF-7_Human0.91078362
176ESR1_21235772_ChIP-Seq_MCF-7_Human0.90578825
177* TTF2_22483619_ChIP-Seq_HELA_Human0.90258921
178TFEB_21752829_ChIP-Seq_HELA_Human0.89479915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.27623012
2MP0008438_abnormal_cutaneous_collagen3.21412899
3MP0003111_abnormal_nucleus_morphology2.99099073
4MP0003283_abnormal_digestive_organ2.53240297
5MP0005275_abnormal_skin_tensile2.37311328
6MP0004957_abnormal_blastocyst_morpholog2.32803113
7MP0010094_abnormal_chromosome_stability2.26064332
8MP0003566_abnormal_cell_adhesion2.18297160
9MP0003878_abnormal_ear_physiology2.01396925
10MP0005377_hearing/vestibular/ear_phenot2.01396925
11MP0005623_abnormal_meninges_morphology1.97593172
12MP0005503_abnormal_tendon_morphology1.97231701
13MP0008877_abnormal_DNA_methylation1.96480221
14MP0010234_abnormal_vibrissa_follicle1.96112469
15MP0000579_abnormal_nail_morphology1.94464787
16MP0003941_abnormal_skin_development1.90381730
17MP0005257_abnormal_intraocular_pressure1.88524612
18MP0000566_synostosis1.86509131
19MP0003077_abnormal_cell_cycle1.83900454
20MP0003123_paternal_imprinting1.83507583
21MP0002653_abnormal_ependyma_morphology1.83065224
22MP0002877_abnormal_melanocyte_morpholog1.81704667
23MP0001299_abnormal_eye_distance/1.77155390
24MP0000762_abnormal_tongue_morphology1.75202398
25MP0000749_muscle_degeneration1.74022888
26MP0001730_embryonic_growth_arrest1.69570234
27MP0004087_abnormal_muscle_fiber1.68418842
28MP0002234_abnormal_pharynx_morphology1.62474372
29MP0004264_abnormal_extraembryonic_tissu1.59910862
30MP0002060_abnormal_skin_morphology1.58550264
31MP0000013_abnormal_adipose_tissue1.56135961
32MP0004233_abnormal_muscle_weight1.54669831
33MP0008058_abnormal_DNA_repair1.52022623
34MP0001849_ear_inflammation1.51627715
35MP0005409_darkened_coat_color1.49021834
36MP0000759_abnormal_skeletal_muscle1.48536547
37MP0010352_gastrointestinal_tract_polyps1.47417855
38MP0003786_premature_aging1.43465147
39MP0003119_abnormal_digestive_system1.42289995
40MP0010368_abnormal_lymphatic_system1.41146409
41MP0005375_adipose_tissue_phenotype1.39798911
42MP0003705_abnormal_hypodermis_morpholog1.38780860
43MP0000350_abnormal_cell_proliferation1.38317777
44MP0004084_abnormal_cardiac_muscle1.38006956
45MP0004858_abnormal_nervous_system1.37450932
46MP0002084_abnormal_developmental_patter1.37043265
47MP0001672_abnormal_embryogenesis/_devel1.37018707
48MP0005380_embryogenesis_phenotype1.37018707
49MP0008057_abnormal_DNA_replication1.36460710
50* MP0002108_abnormal_muscle_morphology1.36313367
51MP0002249_abnormal_larynx_morphology1.35844652
52MP0004859_abnormal_synaptic_plasticity1.34427626
53MP0008007_abnormal_cellular_replicative1.34188887
54MP0003718_maternal_effect1.32731542
55MP0002085_abnormal_embryonic_tissue1.32341586
56MP0000678_abnormal_parathyroid_gland1.31135379
57MP0002909_abnormal_adrenal_gland1.31039332
58MP0001697_abnormal_embryo_size1.29472853
59MP0004185_abnormal_adipocyte_glucose1.29071396
60MP0005076_abnormal_cell_differentiation1.28558824
61MP0006072_abnormal_retinal_apoptosis1.28455626
62MP0004885_abnormal_endolymph1.28039589
63MP0005330_cardiomyopathy1.27372896
64MP0005666_abnormal_adipose_tissue1.26355797
65MP0002896_abnormal_bone_mineralization1.25488977
66MP0000751_myopathy1.24906741
67MP0003091_abnormal_cell_migration1.24652176
68MP0005499_abnormal_olfactory_system1.24143998
69MP0005394_taste/olfaction_phenotype1.24143998
70MP0003984_embryonic_growth_retardation1.20966602
71MP0010630_abnormal_cardiac_muscle1.20585053
72MP0010307_abnormal_tumor_latency1.19966394
73MP0002160_abnormal_reproductive_system1.19654623
74MP0001984_abnormal_olfaction1.18969371
75MP0002088_abnormal_embryonic_growth/wei1.18699157
76MP0002086_abnormal_extraembryonic_tissu1.18013351
77MP0009384_cardiac_valve_regurgitation1.18002438
78MP0002080_prenatal_lethality1.17156126
79MP0002269_muscular_atrophy1.16814831
80MP0004145_abnormal_muscle_electrophysio1.13798665
81MP0003879_abnormal_hair_cell1.13733996
82MP0000467_abnormal_esophagus_morphology1.13697422
83MP0008789_abnormal_olfactory_epithelium1.12872048
84MP0001958_emphysema1.12474706
85MP0003453_abnormal_keratinocyte_physiol1.11729963
86MP0001348_abnormal_lacrimal_gland1.11726956
87MP0000537_abnormal_urethra_morphology1.10925207
88MP0002796_impaired_skin_barrier1.07404058
89MP0000003_abnormal_adipose_tissue1.05615040
90MP0003115_abnormal_respiratory_system1.02645273
91MP0003567_abnormal_fetal_cardiomyocyte1.02213290
92MP0002106_abnormal_muscle_physiology1.01214790
93* MP0005369_muscle_phenotype1.00389972
94MP0004272_abnormal_basement_membrane1.00109012
95MP0008260_abnormal_autophagy1.00022139
96MP0003787_abnormal_imprinting0.99915415
97MP0000747_muscle_weakness0.99679756
98MP0004197_abnormal_fetal_growth/weight/0.98643240
99MP0000750_abnormal_muscle_regeneration0.98502005
100MP0003942_abnormal_urinary_system0.97466446
101* MP0002210_abnormal_sex_determination0.97231159
102MP0000428_abnormal_craniofacial_morphol0.97077507
103MP0002098_abnormal_vibrissa_morphology0.96158195
104MP0009780_abnormal_chondrocyte_physiolo0.96143924
105MP0000462_abnormal_digestive_system0.95256963
106MP0001661_extended_life_span0.94865060
107* MP0001929_abnormal_gametogenesis0.93101169
108MP0008932_abnormal_embryonic_tissue0.92702769
109MP0010030_abnormal_orbit_morphology0.92531080
110MP0005023_abnormal_wound_healing0.91928319
111MP0005620_abnormal_muscle_contractility0.91063196
112MP0003890_abnormal_embryonic-extraembry0.90801535
113MP0000767_abnormal_smooth_muscle0.90465727
114MP0004782_abnormal_surfactant_physiolog0.90178024
115MP0003385_abnormal_body_wall0.89830170
116MP0000383_abnormal_hair_follicle0.89475346
117MP0010678_abnormal_skin_adnexa0.89474279
118MP0005670_abnormal_white_adipose0.89042502
119MP0004215_abnormal_myocardial_fiber0.88657129
120MP0000534_abnormal_ureter_morphology0.88492683
121* MP0001145_abnormal_male_reproductive0.88203717
122MP0000377_abnormal_hair_follicle0.87699553
123MP0002116_abnormal_craniofacial_bone0.87168497
124MP0003950_abnormal_plasma_membrane0.86507206
125MP0003279_aneurysm0.86067427
126MP0003635_abnormal_synaptic_transmissio0.85654430
127MP0002972_abnormal_cardiac_muscle0.84383142
128MP0002089_abnormal_postnatal_growth/wei0.84164854
129MP0003121_genomic_imprinting0.83207206
130MP0004270_analgesia0.83024900
131MP0004043_abnormal_pH_regulation0.82601041
132MP0005508_abnormal_skeleton_morphology0.82538647
133MP0002009_preneoplasia0.81648858
134* MP0003698_abnormal_male_reproductive0.81337537
135MP0000516_abnormal_urinary_system0.80660875
136MP0005367_renal/urinary_system_phenotyp0.80660875
137MP0005621_abnormal_cell_physiology0.80430672
138MP0002697_abnormal_eye_size0.79939759
139MP0003935_abnormal_craniofacial_develop0.79602785
140MP0003861_abnormal_nervous_system0.78886403
141MP0000432_abnormal_head_morphology0.78398725
142MP0003329_amyloid_beta_deposits0.77851842
143MP0001879_abnormal_lymphatic_vessel0.76765425
144MP0003755_abnormal_palate_morphology0.76677891
145MP0005389_reproductive_system_phenotype0.76270290
146MP0001216_abnormal_epidermal_layer0.75772386
147MP0010771_integument_phenotype0.75462577
148* MP0000653_abnormal_sex_gland0.75163079
149MP0006138_congestive_heart_failure0.75099636
150MP0001270_distended_abdomen0.74904539
151MP0001293_anophthalmia0.74331680
152MP0001346_abnormal_lacrimal_gland0.74255542
153MP0002233_abnormal_nose_morphology0.73435724
154MP0000733_abnormal_muscle_development0.73357080
155MP0002822_catalepsy0.72605336
156MP0003937_abnormal_limbs/digits/tail_de0.72551944
157MP0004036_abnormal_muscle_relaxation0.71507983
158MP0005501_abnormal_skin_physiology0.71143638
159MP0005187_abnormal_penis_morphology0.70900506
160MP0002837_dystrophic_cardiac_calcinosis0.69879130
161MP0002184_abnormal_innervation0.69645707
162MP0002127_abnormal_cardiovascular_syste0.69144391

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.41281340
2Exercise-induced myalgia (HP:0003738)3.25112631
3Pelvic girdle muscle weakness (HP:0003749)3.22788028
4Right ventricular cardiomyopathy (HP:0011663)3.22374569
5Difficulty climbing stairs (HP:0003551)3.09280092
6Shoulder girdle muscle weakness (HP:0003547)3.08383899
7Abnormality of the hip-girdle musculature (HP:0001445)2.94721107
8Abnormality of the musculature of the pelvis (HP:0001469)2.94721107
9Atrophic scars (HP:0001075)2.82975440
10Birth length less than 3rd percentile (HP:0003561)2.82248793
11Type 1 muscle fiber predominance (HP:0003803)2.78340243
12Breast hypoplasia (HP:0003187)2.76158817
13Hyperacusis (HP:0010780)2.74170301
14Ependymoma (HP:0002888)2.72165524
15Ankle contracture (HP:0006466)2.68451538
16Abnormality of the labia minora (HP:0012880)2.66879806
17Arterial tortuosity (HP:0005116)2.62304781
18Abnormality of the lower motor neuron (HP:0002366)2.59846686
19Broad face (HP:0000283)2.59630083
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59356041
21Spinal muscular atrophy (HP:0007269)2.52907368
22Selective tooth agenesis (HP:0001592)2.50552766
23Flat acetabular roof (HP:0003180)2.49575980
24Vertebral arch anomaly (HP:0008438)2.48561004
25Bundle branch block (HP:0011710)2.47028619
26Ventricular fibrillation (HP:0001663)2.45479530
27Vascular tortuosity (HP:0004948)2.44289546
28Muscle fiber splitting (HP:0003555)2.38028048
29Premature rupture of membranes (HP:0001788)2.36989225
30Distal lower limb muscle weakness (HP:0009053)2.36955082
31Cervical subluxation (HP:0003308)2.34555032
32Chromsome breakage (HP:0040012)2.34416938
33Short nail (HP:0001799)2.27602575
34Obstructive sleep apnea (HP:0002870)2.27142281
35Distal lower limb amyotrophy (HP:0008944)2.26730080
36Bladder diverticulum (HP:0000015)2.25564691
37Bronchomalacia (HP:0002780)2.24763570
38Ulnar bowing (HP:0003031)2.24685311
39Insulin-resistant diabetes mellitus (HP:0000831)2.22414764
40Increased connective tissue (HP:0009025)2.18279924
41Increased variability in muscle fiber diameter (HP:0003557)2.16795145
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.14218840
43Ureteral duplication (HP:0000073)2.13013794
44Muscle fiber inclusion bodies (HP:0100299)2.12745661
45Abnormality of the umbilical cord (HP:0010881)2.12316280
46Fragile skin (HP:0001030)2.10841743
47Astrocytoma (HP:0009592)2.10729779
48Abnormality of the astrocytes (HP:0100707)2.10729779
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10055179
50Nemaline bodies (HP:0003798)2.06549738
51Round ear (HP:0100830)2.06345481
52Abnormality of the calf musculature (HP:0001430)2.05946574
53Bell-shaped thorax (HP:0001591)2.05872472
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04984736
55Aortic dissection (HP:0002647)2.04242281
56Impulsivity (HP:0100710)2.03031508
57Hyporeflexia of lower limbs (HP:0002600)2.02855172
58Oligodactyly (hands) (HP:0001180)2.02114468
59Ventricular tachycardia (HP:0004756)2.00638956
60Abnormality of the distal phalanges of the toes (HP:0010182)1.99640765
61Exercise-induced muscle cramps (HP:0003710)1.99105184
62Glioma (HP:0009733)1.97320377
63Ulnar deviation of the wrist (HP:0003049)1.96909575
64Abnormality of dentin (HP:0010299)1.96754512
65Neoplasm of the heart (HP:0100544)1.96291937
66Scapular winging (HP:0003691)1.94415317
67Missing ribs (HP:0000921)1.94353619
68Progressive muscle weakness (HP:0003323)1.94062467
69Abnormality of skeletal muscle fiber size (HP:0012084)1.93396809
70Broad metatarsal (HP:0001783)1.91287894
71Breast carcinoma (HP:0003002)1.91127801
72Limb-girdle muscle weakness (HP:0003325)1.90440659
73Advanced eruption of teeth (HP:0006288)1.89893369
74Carpal bone hypoplasia (HP:0001498)1.89572995
75Insomnia (HP:0100785)1.89211560
76Neonatal short-limb short stature (HP:0008921)1.87737582
77Turricephaly (HP:0000262)1.87117589
78Hyperglycemia (HP:0003074)1.87047809
79Aplasia/Hypoplasia of the patella (HP:0006498)1.86190433
80Limb-girdle muscle atrophy (HP:0003797)1.84391514
81Patellar aplasia (HP:0006443)1.84272613
82Areflexia of lower limbs (HP:0002522)1.84160416
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83926486
84Lower limb amyotrophy (HP:0007210)1.82683840
85Rough bone trabeculation (HP:0100670)1.82406549
86Natal tooth (HP:0000695)1.82226476
87Wormian bones (HP:0002645)1.81490788
88Entropion (HP:0000621)1.80113623
89Mildly elevated creatine phosphokinase (HP:0008180)1.80084805
90Aplasia involving bones of the upper limbs (HP:0009823)1.80064378
91Aplasia of the phalanges of the hand (HP:0009802)1.80064378
92Aplasia involving bones of the extremities (HP:0009825)1.80064378
93Absent radius (HP:0003974)1.79196277
94Atelectasis (HP:0100750)1.78812129
95Dysautonomia (HP:0002459)1.77671917
96Pterygium (HP:0001059)1.77468626
97Abnormality of the distal phalanx of the thumb (HP:0009617)1.77276136
98Aplasia/hypoplasia of the humerus (HP:0006507)1.76706346
99Calcaneovalgus deformity (HP:0001848)1.76388721
100Abnormality of the calcaneus (HP:0008364)1.75129203
101Short humerus (HP:0005792)1.74324191
102Hammertoe (HP:0001765)1.74247691
103Glucose intolerance (HP:0000833)1.73773889
104Cerebral hypomyelination (HP:0006808)1.73500325
105Aneurysm (HP:0002617)1.73206353
106Sudden death (HP:0001699)1.72589655
107Volvulus (HP:0002580)1.72324656
108Aortic aneurysm (HP:0004942)1.72219870
109Wrist flexion contracture (HP:0001239)1.71861020
110Facial cleft (HP:0002006)1.70686008
111Stridor (HP:0010307)1.69951261
112Prominent nose (HP:0000448)1.69268023
113Abnormality of the labia (HP:0000058)1.69107573
114Absent forearm bone (HP:0003953)1.68392895
115Aplasia involving forearm bones (HP:0009822)1.68392895
116Shawl scrotum (HP:0000049)1.67591321
117Asymmetric septal hypertrophy (HP:0001670)1.66679633
118Shallow orbits (HP:0000586)1.66128460
119Oligodactyly (HP:0012165)1.65477558
120Breech presentation (HP:0001623)1.64449727
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.63881999
122Colon cancer (HP:0003003)1.61880510
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61640807
124Lip pit (HP:0100267)1.61456710
125Rimmed vacuoles (HP:0003805)1.60687036
126Male infertility (HP:0003251)1.59882916
127Upper limb amyotrophy (HP:0009129)1.59485594
128Distal upper limb amyotrophy (HP:0007149)1.59485594
129Ankyloglossia (HP:0010296)1.59481437
130Distal arthrogryposis (HP:0005684)1.59301918
131Biliary tract neoplasm (HP:0100574)1.58872062
132Popliteal pterygium (HP:0009756)1.58782163
133Meckel diverticulum (HP:0002245)1.58403834
134Abnormal atrioventricular conduction (HP:0005150)1.58072452
135Short 1st metacarpal (HP:0010034)1.57766163
136Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57766163
137Mitral valve prolapse (HP:0001634)1.57599212
138Neck muscle weakness (HP:0000467)1.56809632
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.55840971
140Cerebral aneurysm (HP:0004944)1.55772725
141Cystic hygroma (HP:0000476)1.55699062
142Hyperkalemia (HP:0002153)1.55338136
143Abnormality of the ileum (HP:0001549)1.55116729
144Stillbirth (HP:0003826)1.54846399
145Atrioventricular block (HP:0001678)1.54803007
146Abnormality of the preputium (HP:0100587)1.54460033
147Neoplasm of the oral cavity (HP:0100649)1.54373310
148Trismus (HP:0000211)1.54372106
149Thin ribs (HP:0000883)1.54094652
150Aplasia/Hypoplasia of the earlobes (HP:0009906)1.53769203
151EMG: myopathic abnormalities (HP:0003458)1.53669085
152Hand muscle atrophy (HP:0009130)1.53540228
153Broad distal phalanx of finger (HP:0009836)1.53384066
154Duodenal stenosis (HP:0100867)1.52944465
155Small intestinal stenosis (HP:0012848)1.52944465
156Mitral regurgitation (HP:0001653)1.52653963
157Soft skin (HP:0000977)1.52613867
158Rhinitis (HP:0012384)1.52495360
159Abnormality of permanent molar morphology (HP:0011071)1.52276145
160Abnormality of the dental root (HP:0006486)1.52276145
161Taurodontia (HP:0000679)1.52276145
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.51881114
163Abnormality of the salivary glands (HP:0010286)1.51879910
164Myopathic facies (HP:0002058)1.51665985
165Global brain atrophy (HP:0002283)1.50746449
16611 pairs of ribs (HP:0000878)1.50345722
167Enlarged penis (HP:0000040)1.48694264
168Difficulty running (HP:0009046)1.47609849
169Abnormality of oral frenula (HP:0000190)1.47221560
170Dysmetric saccades (HP:0000641)1.44371050
171Focal seizures (HP:0007359)1.43944418
172Spinal rigidity (HP:0003306)1.43465252
173Abnormality of the proximal phalanges of the hand (HP:0009834)1.42765194
174Short thumb (HP:0009778)1.42758046
175EMG: neuropathic changes (HP:0003445)1.42685026
176Esophageal atresia (HP:0002032)1.42343224
177Proximal amyotrophy (HP:0007126)1.42182139
178Breast aplasia (HP:0100783)1.41239611
179Premature ovarian failure (HP:0008209)1.41198819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.27586279
2EPHA23.63712167
3BUB13.57832613
4NEK13.31988549
5WEE13.25258463
6TSSK63.18391624
7MST1R2.96258792
8BRSK22.79716576
9MET2.60724115
10NTRK12.44658283
11CCNB12.41822948
12NEK22.41100007
13RIPK12.35354128
14SIK12.33874339
15ICK2.30165708
16PDK42.21953400
17PDK32.21953400
18PNCK2.16982481
19TTK2.11877296
20EPHA42.10243349
21BRSK12.02667262
22PTK22.00328076
23MAPK151.97626819
24CAMKK21.82234311
25PLK31.70107717
26LMTK21.61708016
27PDK21.55978445
28SMG11.54503855
29FGFR41.52833978
30PLK11.48917956
31ZAK1.45834393
32PLK41.45706411
33MAP3K91.44551356
34PHKG11.42804843
35PHKG21.42804843
36OBSCN1.42506039
37NTRK31.41383829
38PASK1.40431585
39MAP3K101.30530530
40EEF2K1.22091513
41TTN1.20777559
42DDR21.18974697
43MAP3K71.18968098
44CDC71.17553081
45TRPM71.16180994
46CHEK21.15663434
47TRIB31.13399515
48FER1.12083545
49LATS21.11011406
50EPHB11.10260403
51STK381.06540980
52PRKD31.05054782
53DMPK1.04809726
54LATS11.02591675
55TESK11.00935119
56CAMKK11.00862324
57CDK120.99688462
58PLK20.98643351
59DYRK30.96312462
60ERBB30.95620179
61PRPF4B0.95484992
62PRKCI0.94388249
63SRPK10.91511000
64PTK60.90566667
65NEK60.89887292
66EPHB20.87127673
67AURKB0.85573635
68MAP3K40.85197095
69BRAF0.83633671
70KSR20.83329799
71PDGFRB0.83108071
72MAP2K10.82392872
73AURKA0.81192634
74CHEK10.80349421
75ACVR1B0.79771312
76MAP3K130.78631171
77RET0.76379816
78STK240.76098604
79NEK90.75876267
80PDGFRA0.75706592
81MAPKAPK30.75238204
82MARK10.74389012
83MTOR0.74320634
84PAK60.74245255
85RPS6KB20.73918321
86FGFR20.70466659
87MARK20.69753171
88DAPK20.68576862
89MAP3K60.68120803
90CDK20.67434361
91ERBB40.66094788
92MYLK0.65383880
93MAP3K20.65140876
94WNK10.64822433
95ATR0.64300425
96ALK0.63971107
97CSNK1E0.63856323
98TIE10.63708659
99CDK40.63315221
100SCYL20.62564653
101RPS6KA20.62552917
102DAPK10.62256245
103ARAF0.62113529
104CDC42BPA0.61301742
105ROCK20.60112556
106STK38L0.57399809
107CDK70.57253923
108PKN20.56870878
109MUSK0.55437637
110SIK20.53900064
111PRKD20.53826017
112TAOK10.52742439
113PAK30.52425720
114MAP2K20.51932759
115PRKAA20.51651273
116CAMK2G0.50973334
117TYRO30.50883834
118FGFR10.50496863
119RAF10.50484370
120EPHA30.50360382
121ATM0.49374604
122CDK80.48828799
123CDK10.48811415
124MOS0.47342296
125MAPK120.47196923
126CAMK2B0.46134630
127KSR10.45893998
128SGK30.45809631
129MAP3K80.45205853
130CDK90.44766260
131MAPK110.44760036
132CDK30.44357291
133ROCK10.44013918
134BMX0.43911183
135PAK10.43519438
136FGFR30.42400395
137CAMK1G0.41807132
138STK30.41779260
139NME10.41678698
140MAP2K40.41604688
141BRD40.41573010
142PAK20.41502927
143CASK0.40581214
144BCR0.40388423
145PRKDC0.39333786
146EIF2AK10.39226766
147PRKAA10.39002085
148STK110.38967209
149MAPK100.38914118
150LIMK10.38631625
151PAK40.36398651
152PRKCG0.36055976
153CDK60.35798007
154PDPK10.35196044
155MAP3K30.35071753
156RPS6KA40.35056905
157MAP3K10.35042756
158GSK3B0.33492849
159NTRK20.33415438
160ERN10.32574529
161MELK0.32142830
162ILK0.31734930
163AKT20.30408282
164MINK10.29531505

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.99427134
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37575012
3RNA transport_Homo sapiens_hsa030132.36045340
4Cell cycle_Homo sapiens_hsa041102.09433435
5Oocyte meiosis_Homo sapiens_hsa041142.07803572
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.84331522
7Mismatch repair_Homo sapiens_hsa034301.83953381
8RNA polymerase_Homo sapiens_hsa030201.68162276
9Circadian rhythm_Homo sapiens_hsa047101.58953519
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56517245
11DNA replication_Homo sapiens_hsa030301.53004906
12Regulation of autophagy_Homo sapiens_hsa041401.48286812
13Spliceosome_Homo sapiens_hsa030401.45727687
14Insulin secretion_Homo sapiens_hsa049111.42729213
15mTOR signaling pathway_Homo sapiens_hsa041501.41168702
16Long-term potentiation_Homo sapiens_hsa047201.39956594
17p53 signaling pathway_Homo sapiens_hsa041151.39253367
18Olfactory transduction_Homo sapiens_hsa047401.37264345
19Thyroid cancer_Homo sapiens_hsa052161.34999369
20Synaptic vesicle cycle_Homo sapiens_hsa047211.32766489
21Nucleotide excision repair_Homo sapiens_hsa034201.30891593
22Amphetamine addiction_Homo sapiens_hsa050311.30443890
23Nicotine addiction_Homo sapiens_hsa050331.29286059
24Base excision repair_Homo sapiens_hsa034101.26971987
25Proteoglycans in cancer_Homo sapiens_hsa052051.26278940
26Notch signaling pathway_Homo sapiens_hsa043301.24439672
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23929147
28mRNA surveillance pathway_Homo sapiens_hsa030151.21788564
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20159522
30Axon guidance_Homo sapiens_hsa043601.18693845
31Fanconi anemia pathway_Homo sapiens_hsa034601.17693130
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16774884
33Lysine degradation_Homo sapiens_hsa003101.16111257
34Phenylalanine metabolism_Homo sapiens_hsa003601.12962768
35Taste transduction_Homo sapiens_hsa047421.12536144
36ErbB signaling pathway_Homo sapiens_hsa040121.10555443
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09731982
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09441971
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.08015125
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07897556
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07576864
42Circadian entrainment_Homo sapiens_hsa047131.07178851
43Fructose and mannose metabolism_Homo sapiens_hsa000511.05825894
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05259591
45Other glycan degradation_Homo sapiens_hsa005111.04341011
46Arginine biosynthesis_Homo sapiens_hsa002201.04294688
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04188061
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04056646
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02594676
50Estrogen signaling pathway_Homo sapiens_hsa049151.01247498
51VEGF signaling pathway_Homo sapiens_hsa043701.00753159
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00662311
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00276915
54Bile secretion_Homo sapiens_hsa049760.99921918
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99085620
56Chronic myeloid leukemia_Homo sapiens_hsa052200.98643652
57Hippo signaling pathway_Homo sapiens_hsa043900.97516595
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95266607
59Biosynthesis of amino acids_Homo sapiens_hsa012300.95217538
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94280452
61Renal cell carcinoma_Homo sapiens_hsa052110.94008393
62Basal cell carcinoma_Homo sapiens_hsa052170.93935157
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93461936
64RNA degradation_Homo sapiens_hsa030180.93292126
65MicroRNAs in cancer_Homo sapiens_hsa052060.93006610
66Tight junction_Homo sapiens_hsa045300.92267472
67Choline metabolism in cancer_Homo sapiens_hsa052310.92176339
68Basal transcription factors_Homo sapiens_hsa030220.90524132
69Insulin resistance_Homo sapiens_hsa049310.90429046
70Pancreatic secretion_Homo sapiens_hsa049720.90387654
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89431511
72Oxytocin signaling pathway_Homo sapiens_hsa049210.88995365
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88711636
74Prion diseases_Homo sapiens_hsa050200.88225701
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87796710
76Purine metabolism_Homo sapiens_hsa002300.87640620
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87090654
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85232953
79Thyroid hormone synthesis_Homo sapiens_hsa049180.84659877
80Type II diabetes mellitus_Homo sapiens_hsa049300.84077248
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84074343
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83987795
83Inositol phosphate metabolism_Homo sapiens_hsa005620.83590209
84Glucagon signaling pathway_Homo sapiens_hsa049220.82842651
85ABC transporters_Homo sapiens_hsa020100.82807322
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81496480
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.81146845
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80673491
89Dilated cardiomyopathy_Homo sapiens_hsa054140.80646137
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.80202283
91Hedgehog signaling pathway_Homo sapiens_hsa043400.78746280
92Dopaminergic synapse_Homo sapiens_hsa047280.78474857
93Adherens junction_Homo sapiens_hsa045200.78465921
94GnRH signaling pathway_Homo sapiens_hsa049120.78041809
95Salivary secretion_Homo sapiens_hsa049700.78021301
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77587551
97Glutamatergic synapse_Homo sapiens_hsa047240.77351975
98Amoebiasis_Homo sapiens_hsa051460.76755914
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76044204
100Pancreatic cancer_Homo sapiens_hsa052120.75294689
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.75280377
102Renin secretion_Homo sapiens_hsa049240.75135983
103Collecting duct acid secretion_Homo sapiens_hsa049660.74760769
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.74719547
105Vibrio cholerae infection_Homo sapiens_hsa051100.74244871
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73744627
107Non-small cell lung cancer_Homo sapiens_hsa052230.73623502
108TGF-beta signaling pathway_Homo sapiens_hsa043500.73615383
109Gap junction_Homo sapiens_hsa045400.73280973
110ECM-receptor interaction_Homo sapiens_hsa045120.73256169
111Prostate cancer_Homo sapiens_hsa052150.73163352
112Carbon metabolism_Homo sapiens_hsa012000.73076057
113Gastric acid secretion_Homo sapiens_hsa049710.72944233
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.72859475
115Arginine and proline metabolism_Homo sapiens_hsa003300.72817298
116Dorso-ventral axis formation_Homo sapiens_hsa043200.71728059
117Sphingolipid metabolism_Homo sapiens_hsa006000.71031911
118GABAergic synapse_Homo sapiens_hsa047270.70346083
119Pentose phosphate pathway_Homo sapiens_hsa000300.69112412
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68022658
121Calcium signaling pathway_Homo sapiens_hsa040200.67718970
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.66795232
123FoxO signaling pathway_Homo sapiens_hsa040680.66250265
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65402051
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63793655
126Colorectal cancer_Homo sapiens_hsa052100.63329562
127Pyrimidine metabolism_Homo sapiens_hsa002400.63131261
128Morphine addiction_Homo sapiens_hsa050320.62560021
129Protein digestion and absorption_Homo sapiens_hsa049740.62212526
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62055117
131Bladder cancer_Homo sapiens_hsa052190.61911805
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.61783395
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.61474088
134Non-homologous end-joining_Homo sapiens_hsa034500.61328806
135Insulin signaling pathway_Homo sapiens_hsa049100.60464261
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.60360854
137Viral carcinogenesis_Homo sapiens_hsa052030.60293851
138AMPK signaling pathway_Homo sapiens_hsa041520.59945695
139Small cell lung cancer_Homo sapiens_hsa052220.59726999
140Melanogenesis_Homo sapiens_hsa049160.58964046
141Epstein-Barr virus infection_Homo sapiens_hsa051690.57632429
142N-Glycan biosynthesis_Homo sapiens_hsa005100.57546708
143Phototransduction_Homo sapiens_hsa047440.57405505
144Glioma_Homo sapiens_hsa052140.56669722
145Wnt signaling pathway_Homo sapiens_hsa043100.56255391
146Rap1 signaling pathway_Homo sapiens_hsa040150.56185426
147Alcoholism_Homo sapiens_hsa050340.55919823
148Homologous recombination_Homo sapiens_hsa034400.55592057
149Pathways in cancer_Homo sapiens_hsa052000.55560182
150Cocaine addiction_Homo sapiens_hsa050300.54836480
151HTLV-I infection_Homo sapiens_hsa051660.54690741
152Focal adhesion_Homo sapiens_hsa045100.54672977
153Long-term depression_Homo sapiens_hsa047300.54663872
154Endometrial cancer_Homo sapiens_hsa052130.54595516
155Histidine metabolism_Homo sapiens_hsa003400.52340823

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