SUN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.61704678
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61704678
3positive regulation of gamma-delta T cell activation (GO:0046645)5.10282452
4antigen processing and presentation of endogenous antigen (GO:0019883)4.99749471
5negative regulation of cell killing (GO:0031342)4.93005244
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93005244
7regulation of gamma-delta T cell differentiation (GO:0045586)4.78037183
8leukocyte aggregation (GO:0070486)4.49912688
9positive regulation of histone deacetylation (GO:0031065)4.31389696
10positive thymic T cell selection (GO:0045059)4.30252935
11regulation of gamma-delta T cell activation (GO:0046643)4.30131268
12detection of other organism (GO:0098543)4.13421994
13detection of bacterium (GO:0016045)4.10772981
14negative regulation of lymphocyte mediated immunity (GO:0002707)3.74443317
15negative regulation of phagocytosis (GO:0050765)3.74319638
16defense response to fungus (GO:0050832)3.66632747
17negative T cell selection (GO:0043383)3.62533956
18thymic T cell selection (GO:0045061)3.59731940
19macrophage activation involved in immune response (GO:0002281)3.54936091
20negative thymic T cell selection (GO:0045060)3.54809904
21positive T cell selection (GO:0043368)3.53895894
22negative regulation of leukocyte mediated immunity (GO:0002704)3.49849502
23negative regulation of T cell mediated immunity (GO:0002710)3.48488981
24neutrophil activation involved in immune response (GO:0002283)3.42941505
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37047628
26response to peptidoglycan (GO:0032494)3.36881634
27detection of external biotic stimulus (GO:0098581)3.35047773
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34458902
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32424482
30positive regulation of B cell differentiation (GO:0045579)3.31832498
31T cell selection (GO:0045058)3.29196650
32cellular response to interleukin-15 (GO:0071350)3.28395939
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23970419
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.20704848
35activated T cell proliferation (GO:0050798)3.20491519
36killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.17343996
37disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.17343996
38response to fungus (GO:0009620)3.16269233
39regulation of B cell receptor signaling pathway (GO:0050855)3.14564539
40regulation of tolerance induction (GO:0002643)3.11371020
41cellular extravasation (GO:0045123)3.09368015
42growth hormone receptor signaling pathway (GO:0060396)3.09224063
43antigen processing and presentation via MHC class Ib (GO:0002475)3.05225149
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05133796
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03971527
46pentose-phosphate shunt (GO:0006098)3.03617445
47positive regulation of protein deacetylation (GO:0090312)3.00621586
48positive regulation of fatty acid beta-oxidation (GO:0032000)2.98070837
49regulation of fatty acid beta-oxidation (GO:0031998)2.97518957
50response to interleukin-15 (GO:0070672)2.94979591
51regulation of B cell differentiation (GO:0045577)2.93577898
52valine metabolic process (GO:0006573)2.92639280
53germinal center formation (GO:0002467)2.91484432
54detection of biotic stimulus (GO:0009595)2.90766013
55regulation of leukocyte degranulation (GO:0043300)2.90466481
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89576072
57regulation of natural killer cell mediated immunity (GO:0002715)2.89576072
58signal complex assembly (GO:0007172)2.88804104
59positive regulation of Rap GTPase activity (GO:0032854)2.88586892
60response to type I interferon (GO:0034340)2.87783743
61immunoglobulin mediated immune response (GO:0016064)2.87625891
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87142272
63type I interferon signaling pathway (GO:0060337)2.87105483
64cellular response to type I interferon (GO:0071357)2.87105483
65response to laminar fluid shear stress (GO:0034616)2.85877889
66natural killer cell differentiation (GO:0001779)2.85876922
67regulation of mast cell degranulation (GO:0043304)2.85520621
68tolerance induction (GO:0002507)2.82663436
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82153940
70negative regulation of granulocyte differentiation (GO:0030853)2.81688314
71mannose metabolic process (GO:0006013)2.80562695
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80333200
73negative regulation of type 2 immune response (GO:0002829)2.80147736
74detection of molecule of bacterial origin (GO:0032490)2.79900001
75negative regulation of innate immune response (GO:0045824)2.78396868
76alpha-linolenic acid metabolic process (GO:0036109)2.77753859
77negative regulation of erythrocyte differentiation (GO:0045647)2.77189341
78regulation of ARF protein signal transduction (GO:0032012)2.75338484
79positive regulation of granulocyte differentiation (GO:0030854)2.74838641
80myeloid cell activation involved in immune response (GO:0002275)2.74179250
81B cell receptor signaling pathway (GO:0050853)2.73349825
82regulation of alpha-beta T cell proliferation (GO:0046640)2.72225612
83regulation of T-helper 2 cell differentiation (GO:0045628)2.72142066
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70507566
85leukocyte cell-cell adhesion (GO:0007159)2.69713061
86germ cell migration (GO:0008354)2.69043099
87response to host immune response (GO:0052572)2.68617323
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68617323
89regulation of T cell tolerance induction (GO:0002664)2.66791560
90regulation of T cell mediated cytotoxicity (GO:0001914)2.66782552
91T cell migration (GO:0072678)2.66238513
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66073605
93response to host (GO:0075136)2.66073605
94response to host defenses (GO:0052200)2.66073605
95neutrophil activation (GO:0042119)2.65812922
96T cell homeostasis (GO:0043029)2.65790460
97NADPH regeneration (GO:0006740)2.64972370
98low-density lipoprotein particle clearance (GO:0034383)2.62501126
99regulation of necroptotic process (GO:0060544)2.59748733
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58861188
101cellular response to growth hormone stimulus (GO:0071378)2.58551501
102interferon-gamma-mediated signaling pathway (GO:0060333)2.57631700
103interferon-gamma production (GO:0032609)2.54139185
104T cell costimulation (GO:0031295)2.53969464
105regulation of mast cell activation involved in immune response (GO:0033006)2.53817681
106negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53383984
107regulation of extracellular matrix disassembly (GO:0010715)2.52823525
108regulation of interleukin-2 biosynthetic process (GO:0045076)2.51922605
109negative regulation of interleukin-12 production (GO:0032695)2.51358347
110NIK/NF-kappaB signaling (GO:0038061)2.50546600
111regulation of granulocyte differentiation (GO:0030852)2.50053508
112regulation of sequestering of triglyceride (GO:0010889)2.49900521
113regulation of regulated secretory pathway (GO:1903305)2.49613882
114lymphocyte migration (GO:0072676)2.49193322
115negative regulation of interleukin-6 production (GO:0032715)2.48154382
116T cell receptor signaling pathway (GO:0050852)2.48109373
117cortical actin cytoskeleton organization (GO:0030866)2.47874266
118defense response to protozoan (GO:0042832)2.47503781
119lymphocyte costimulation (GO:0031294)2.47201089
120regulation of interferon-beta biosynthetic process (GO:0045357)2.46518030
121positive regulation by organism of defense response of other organism involved in symbiotic interact2.45802909
122modulation by symbiont of host immune response (GO:0052553)2.45802909
123positive regulation by symbiont of host defense response (GO:0052509)2.45802909
124modulation by symbiont of host defense response (GO:0052031)2.45802909
125modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45802909
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45802909
127antigen receptor-mediated signaling pathway (GO:0050851)2.44624893
128regulation of cholesterol storage (GO:0010885)2.44149993
129phospholipid homeostasis (GO:0055091)2.42931443
130positive regulation of tolerance induction (GO:0002645)2.41458927
131protein localization to endosome (GO:0036010)2.39579647
132macrophage differentiation (GO:0030225)2.39084543
133response to muramyl dipeptide (GO:0032495)2.36717842
134positive regulation of lamellipodium assembly (GO:0010592)2.35659794
135killing of cells of other organism (GO:0031640)2.35404547
136disruption of cells of other organism (GO:0044364)2.35404547
137negative regulation of cell size (GO:0045792)2.34989534
138adaptation of signaling pathway (GO:0023058)2.32011018
139positive regulation of fatty acid oxidation (GO:0046321)2.31531704
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30737757
141positive regulation of natural killer cell differentiation (GO:0032825)2.30411140
142cellular response to zinc ion (GO:0071294)2.30031152
143negative regulation of heart growth (GO:0061117)2.28758238
144negative regulation of cardiac muscle tissue growth (GO:0055022)2.28758238
145respiratory burst (GO:0045730)2.27051857
146regulation of response to interferon-gamma (GO:0060330)2.26718945
1472-oxoglutarate metabolic process (GO:0006103)2.26369239
148pinocytosis (GO:0006907)2.26089888
149leukocyte migration involved in inflammatory response (GO:0002523)2.25584979
150neutrophil mediated immunity (GO:0002446)2.24702464
151regulation of triglyceride catabolic process (GO:0010896)2.24189829
152regulation of fatty acid oxidation (GO:0046320)2.23982301
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.23245897
154regulation of cholesterol homeostasis (GO:2000188)2.23070598
155positive regulation of lipid catabolic process (GO:0050996)2.22956929
156regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.22148460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88447025
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62224456
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.54131325
4MYC_22102868_ChIP-Seq_BL_Human3.44234278
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.32916380
6VDR_21846776_ChIP-Seq_THP-1_Human3.08277215
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04414074
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.83934595
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.76966095
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68774399
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.57280147
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46707478
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45814627
14MAF_26560356_Chip-Seq_TH1_Human2.45599491
15RUNX_20019798_ChIP-Seq_JUKART_Human2.38221587
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33258951
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30602585
18KDM2B_26808549_Chip-Seq_DND41_Human2.30230432
19* UTX_26944678_Chip-Seq_JUKART_Human2.27929457
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26911365
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26074326
22SCL_19346495_ChIP-Seq_HPC-7_Human2.23701524
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23263208
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23118981
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.20840155
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17474384
27VDR_24763502_ChIP-Seq_THP-1_Human2.12321401
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12189275
29RXR_22158963_ChIP-Seq_LIVER_Mouse2.10711368
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10157390
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07476010
32* MYB_26560356_Chip-Seq_TH2_Human2.05887383
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.05492815
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.97707313
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95414374
36CLOCK_20551151_ChIP-Seq_293T_Human1.89366571
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.85130901
38* MYB_26560356_Chip-Seq_TH1_Human1.83884992
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80100399
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.80061891
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.70453311
42SPI1_23127762_ChIP-Seq_K562_Human1.68429650
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62761100
44LXR_22292898_ChIP-Seq_THP-1_Human1.61230267
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60166784
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.55696586
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.54711568
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54421469
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54144340
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53566087
51MAF_26560356_Chip-Seq_TH2_Human1.52261597
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51001903
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48993800
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47373568
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44999340
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41850173
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41071333
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38799749
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35856715
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35512637
61* SPI1_23547873_ChIP-Seq_NB4_Human1.33389691
62GATA3_27048872_Chip-Seq_THYMUS_Human1.32927730
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29802661
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27868765
65* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25925806
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25200365
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.23526483
68* FOXM1_23109430_ChIP-Seq_U2OS_Human1.23410910
69RACK7_27058665_Chip-Seq_MCF-7_Human1.23063886
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.21743853
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.21007773
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.19106432
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19018580
74NCOR1_26117541_ChIP-Seq_K562_Human1.17275738
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15550490
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15531074
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15491963
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15192317
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14756058
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13065977
81PU_27001747_Chip-Seq_BMDM_Mouse1.12782159
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.12067703
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10855858
84GATA1_19941826_ChIP-Seq_K562_Human1.10662655
85* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10575945
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09811200
87GATA2_19941826_ChIP-Seq_K562_Human1.09356741
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09166785
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08992325
90* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08545069
91P68_20966046_ChIP-Seq_HELA_Human1.08528119
92BCOR_27268052_Chip-Seq_Bcells_Human1.08094577
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07185272
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06006352
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05961817
96* SMC4_20622854_ChIP-Seq_HELA_Human1.05404826
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.05237662
98GATA1_22025678_ChIP-Seq_K562_Human1.04868938
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04407274
100BCL6_27268052_Chip-Seq_Bcells_Human1.04176407
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.04055283
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.04055283
103E2F7_22180533_ChIP-Seq_HELA_Human1.03424086
104KDM2B_26808549_Chip-Seq_K562_Human1.02204062
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.00956301
106ELF1_20517297_ChIP-Seq_JURKAT_Human0.99344182
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99008293
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98825779
109* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98448987
110VDR_24787735_ChIP-Seq_THP-1_Human0.97672001
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97261087
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96022216
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95999792
114CIITA_25753668_ChIP-Seq_RAJI_Human0.95750420
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95589658
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95403684
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93248747
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92618547
119DROSHA_22980978_ChIP-Seq_HELA_Human0.92374891
120* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91946098
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91746928
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90545038
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90481445
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87490547
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86747628
126ATF3_27146783_Chip-Seq_COLON_Human0.86642714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.33512820
2MP0003300_gastrointestinal_ulcer3.00446349
3MP0003436_decreased_susceptibility_to2.67204058
4MP0000685_abnormal_immune_system2.43728288
5MP0001835_abnormal_antigen_presentation2.32211038
6MP0003705_abnormal_hypodermis_morpholog2.31991218
7MP0009278_abnormal_bone_marrow2.24115728
8MP0002166_altered_tumor_susceptibility2.23382331
9MP0003191_abnormal_cellular_cholesterol2.11987795
10MP0001800_abnormal_humoral_immune2.07524116
11MP0003763_abnormal_thymus_physiology2.04032158
12MP0005464_abnormal_platelet_physiology2.03757758
13MP0005387_immune_system_phenotype2.00943253
14MP0001790_abnormal_immune_system2.00943253
15MP0008260_abnormal_autophagy1.99220465
16MP0004185_abnormal_adipocyte_glucose1.96448583
17MP0004947_skin_inflammation1.93611648
18MP0004130_abnormal_muscle_cell1.86202128
19MP0005451_abnormal_body_composition1.85606921
20MP0002419_abnormal_innate_immunity1.84236253
21MP0008961_abnormal_basal_metabolism1.82236497
22MP0002452_abnormal_antigen_presenting1.78355749
23MP0005000_abnormal_immune_tolerance1.77554444
24MP0002396_abnormal_hematopoietic_system1.77487788
25MP0002420_abnormal_adaptive_immunity1.75201027
26MP0001819_abnormal_immune_cell1.73572990
27MP0003566_abnormal_cell_adhesion1.72700522
28MP0005025_abnormal_response_to1.72595528
29MP0009785_altered_susceptibility_to1.71328056
30MP0002723_abnormal_immune_serum1.70820216
31MP0004808_abnormal_hematopoietic_stem1.69577738
32MP0002398_abnormal_bone_marrow1.68272637
33MP0005671_abnormal_response_to1.66504093
34MP0005360_urolithiasis1.64784643
35MP0009840_abnormal_foam_cell1.62950398
36MP0005666_abnormal_adipose_tissue1.61070141
37MP0004381_abnormal_hair_follicle1.60278036
38MP0005076_abnormal_cell_differentiation1.58444765
39MP0000465_gastrointestinal_hemorrhage1.58100340
40MP0001873_stomach_inflammation1.56929667
41MP0003690_abnormal_glial_cell1.55494863
42MP0002405_respiratory_system_inflammati1.54046602
43MP0005670_abnormal_white_adipose1.52764856
44MP0000716_abnormal_immune_system1.52471288
45MP0002006_tumorigenesis1.50630776
46MP0001545_abnormal_hematopoietic_system1.48143020
47MP0005397_hematopoietic_system_phenotyp1.48143020
48MP0004510_myositis1.47352909
49MP0010155_abnormal_intestine_physiology1.42303161
50MP0000569_abnormal_digit_pigmentation1.41191945
51MP0002722_abnormal_immune_system1.39544470
52MP0001533_abnormal_skeleton_physiology1.39446952
53MP0001853_heart_inflammation1.39333706
54MP0001845_abnormal_inflammatory_respons1.38628666
55MP0000689_abnormal_spleen_morphology1.37347406
56MP0010329_abnormal_lipoprotein_level1.36620571
57MP0005365_abnormal_bile_salt1.35872814
58MP0000703_abnormal_thymus_morphology1.32774181
59MP0000609_abnormal_liver_physiology1.31674035
60MP0008438_abnormal_cutaneous_collagen1.30498475
61MP0002139_abnormal_hepatobiliary_system1.30036361
62MP0002429_abnormal_blood_cell1.27327520
63MP0010352_gastrointestinal_tract_polyps1.26907592
64MP0005023_abnormal_wound_healing1.26408986
65MP0005058_abnormal_lysosome_morphology1.22530717
66MP0002933_joint_inflammation1.22370813
67MP0005375_adipose_tissue_phenotype1.22325812
68MP0006082_CNS_inflammation1.21284397
69MP0004883_abnormal_blood_vessel1.21230660
70MP0003724_increased_susceptibility_to1.18889914
71MP0003075_altered_response_to1.16500186
72MP0001851_eye_inflammation1.16118518
73MP0003172_abnormal_lysosome_physiology1.15687690
74MP0002132_abnormal_respiratory_system1.13721062
75MP0003252_abnormal_bile_duct1.13385474
76MP0005275_abnormal_skin_tensile1.11685983
77MP0000733_abnormal_muscle_development1.11506566
78MP0003091_abnormal_cell_migration1.11283673
79MP0005310_abnormal_salivary_gland1.10572715
80MP0002971_abnormal_brown_adipose1.08695359
81MP0008469_abnormal_protein_level1.08021809
82MP0005166_decreased_susceptibility_to1.07260238
83MP0003183_abnormal_peptide_metabolism1.07236233
84MP0002837_dystrophic_cardiac_calcinosis1.06469738
85MP0003329_amyloid_beta_deposits1.03446746
86MP0000343_altered_response_to1.02292898
87MP0000858_altered_metastatic_potential0.99834925
88MP0009333_abnormal_splenocyte_physiolog0.99272069
89MP0002009_preneoplasia0.97993865
90MP0003448_altered_tumor_morphology0.97225501
91MP0003045_fibrosis0.96624305
92MP0003279_aneurysm0.95121362
93MP0010234_abnormal_vibrissa_follicle0.94886047
94MP0005164_abnormal_response_to0.93356656
95MP0003828_pulmonary_edema0.92644638
96MP0003453_abnormal_keratinocyte_physiol0.91596100
97MP0003866_abnormal_defecation0.91541779
98MP0009115_abnormal_fat_cell0.90603262
99MP0010307_abnormal_tumor_latency0.90458995
100MP0010630_abnormal_cardiac_muscle0.90240064
101MP0005085_abnormal_gallbladder_physiolo0.89964281
102MP0002970_abnormal_white_adipose0.89544609
103MP0004087_abnormal_muscle_fiber0.88346352
104MP0002148_abnormal_hypersensitivity_rea0.88086188
105MP0005390_skeleton_phenotype0.87260800
106MP0000920_abnormal_myelination0.87115652
107MP0008004_abnormal_stomach_pH0.84871336
108MP0005409_darkened_coat_color0.84776384
109MP0002998_abnormal_bone_remodeling0.84578623
110MP0002877_abnormal_melanocyte_morpholog0.82082360
111MP0005334_abnormal_fat_pad0.81377667
112MP0001958_emphysema0.81313519
113MP0002060_abnormal_skin_morphology0.81036877
114MP0000249_abnormal_blood_vessel0.80826464
115MP0000604_amyloidosis0.80355418
116MP0001348_abnormal_lacrimal_gland0.80057932
117MP0000598_abnormal_liver_morphology0.79978040
118MP0008874_decreased_physiological_sensi0.78257049
119MP0001849_ear_inflammation0.77147644
120MP0001663_abnormal_digestive_system0.76652441
121MP0009764_decreased_sensitivity_to0.73276967
122MP0004858_abnormal_nervous_system0.71654693
123MP0003795_abnormal_bone_structure0.70349246
124MP0000490_abnormal_crypts_of0.68275712
125MP0009763_increased_sensitivity_to0.67086106
126MP0000767_abnormal_smooth_muscle0.63754924
127MP0002133_abnormal_respiratory_system0.63338365
128MP0005388_respiratory_system_phenotype0.63338365

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.37226470
2Orchitis (HP:0100796)3.57600538
3Recurrent gram-negative bacterial infections (HP:0005420)3.26260187
4Optic neuritis (HP:0100653)3.23961837
5Retrobulbar optic neuritis (HP:0100654)3.23961837
6Recurrent fungal infections (HP:0002841)3.22575982
7Cerebral aneurysm (HP:0004944)3.18160901
8Recurrent abscess formation (HP:0002722)3.16040503
9Recurrent bacterial skin infections (HP:0005406)3.14362166
10Stomatitis (HP:0010280)2.96897822
11Increased density of long bones (HP:0006392)2.95559898
12Recurrent viral infections (HP:0004429)2.95333736
13Cellulitis (HP:0100658)2.89501132
14Myocardial infarction (HP:0001658)2.85666351
15Spontaneous hematomas (HP:0007420)2.83106230
16Increased IgE level (HP:0003212)2.81979944
17Verrucae (HP:0200043)2.77938355
18Papilloma (HP:0012740)2.77938355
19Abnormal platelet volume (HP:0011876)2.73741813
20Chronic otitis media (HP:0000389)2.65813121
21Inflammation of the large intestine (HP:0002037)2.65146469
22Gastrointestinal inflammation (HP:0004386)2.61417354
23T lymphocytopenia (HP:0005403)2.60441194
24Encephalitis (HP:0002383)2.59581478
25Deep venous thrombosis (HP:0002625)2.58171909
26Colitis (HP:0002583)2.56903694
27Aortic aneurysm (HP:0004942)2.56328267
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.55985332
29Frequent falls (HP:0002359)2.53054356
30Abnormality of the fingertips (HP:0001211)2.52965719
31Keratoconjunctivitis sicca (HP:0001097)2.50625511
32Obstructive sleep apnea (HP:0002870)2.49590009
33Nasal polyposis (HP:0100582)2.49437547
34Abnormality of T cell number (HP:0011839)2.45838422
35Prolonged bleeding time (HP:0003010)2.45832508
36Myositis (HP:0100614)2.44513273
37Papilledema (HP:0001085)2.41998109
38Elevated erythrocyte sedimentation rate (HP:0003565)2.40891732
39Increased mean platelet volume (HP:0011877)2.37448709
40Abnormality of the nasal mucosa (HP:0000433)2.37171457
41Recurrent skin infections (HP:0001581)2.36291248
42Gingival bleeding (HP:0000225)2.36275354
43Complement deficiency (HP:0004431)2.35014920
44Slow saccadic eye movements (HP:0000514)2.34976187
45Agammaglobulinemia (HP:0004432)2.34628126
46Pulmonary infiltrates (HP:0002113)2.32391252
47Meningitis (HP:0001287)2.32014193
48Osteolytic defects of the hand bones (HP:0009699)2.31420014
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.31420014
50Chest pain (HP:0100749)2.29964631
51Hematochezia (HP:0002573)2.25259553
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24662359
53Gingivitis (HP:0000230)2.24209230
54Periodontitis (HP:0000704)2.23391539
55Obstructive lung disease (HP:0006536)2.22608326
56Chronic obstructive pulmonary disease (HP:0006510)2.22608326
57Keratoconjunctivitis (HP:0001096)2.22424706
58Hyperacusis (HP:0010780)2.20800212
59Epistaxis (HP:0000421)2.19735075
60Amyloidosis (HP:0011034)2.19204283
61Abnormal platelet function (HP:0011869)2.19159706
62Impaired platelet aggregation (HP:0003540)2.19159706
63Mitral valve prolapse (HP:0001634)2.17412794
64Chronic mucocutaneous candidiasis (HP:0002728)2.16285295
65Recurrent cutaneous fungal infections (HP:0011370)2.16285295
66IgM deficiency (HP:0002850)2.15366941
67Pustule (HP:0200039)2.12663771
68Autoimmune thrombocytopenia (HP:0001973)2.09448134
69Recurrent bronchitis (HP:0002837)2.08980426
70Dysostosis multiplex (HP:0000943)2.08118324
71Hypochromic anemia (HP:0001931)2.07180419
72Hyporeflexia of lower limbs (HP:0002600)2.07140843
73Increased connective tissue (HP:0009025)2.07024784
74Peritonitis (HP:0002586)2.06849096
75Panhypogammaglobulinemia (HP:0003139)2.06428427
76Abnormality of T cells (HP:0002843)2.06324377
77Arterial thrombosis (HP:0004420)2.05113030
78Mediastinal lymphadenopathy (HP:0100721)2.04850847
79Eosinophilia (HP:0001880)2.04347866
80Lymphopenia (HP:0001888)2.04043851
81Systemic lupus erythematosus (HP:0002725)2.02220161
82Disproportionate tall stature (HP:0001519)2.02208451
83Difficulty running (HP:0009046)1.98752314
84Gastrointestinal stroma tumor (HP:0100723)1.98686921
85Broad face (HP:0000283)1.98660948
86Aneurysm (HP:0002617)1.98373673
87Persistence of primary teeth (HP:0006335)1.96650935
88Episodic fever (HP:0001954)1.96531142
89Dilatation of the ascending aorta (HP:0005111)1.95986460
90Abnormality of complement system (HP:0005339)1.95652167
91Polygenic inheritance (HP:0010982)1.94408873
92Emphysema (HP:0002097)1.92102817
93Sepsis (HP:0100806)1.91423523
94Abnormality of cells of the lymphoid lineage (HP:0012140)1.90943933
95Segmental peripheral demyelination/remyelination (HP:0003481)1.90598408
96Xanthomatosis (HP:0000991)1.90403023
97Purpura (HP:0000979)1.90219910
98Pulmonary embolism (HP:0002204)1.90130255
99Hypergammaglobulinemia (HP:0010702)1.90065734
100Supranuclear gaze palsy (HP:0000605)1.89518056
101Vasculitis (HP:0002633)1.88125314
102Interstitial pulmonary disease (HP:0006530)1.86600709
103Osteomyelitis (HP:0002754)1.84424905
104Skin ulcer (HP:0200042)1.84223894
105Hemorrhage of the eye (HP:0011885)1.84169598
106Leukocytosis (HP:0001974)1.84157069
107Type 1 muscle fiber predominance (HP:0003803)1.84096446
108Increased cerebral lipofuscin (HP:0011813)1.83951475
109Ulnar deviation of the wrist (HP:0003049)1.83811868
110Abnormality of macrophages (HP:0004311)1.83656212
111Urticaria (HP:0001025)1.83531740
112Mitral stenosis (HP:0001718)1.82615658
113Menorrhagia (HP:0000132)1.82579808
114B lymphocytopenia (HP:0010976)1.82262448
115Abnormality of B cell number (HP:0010975)1.82262448
116Thrombocytosis (HP:0001894)1.81667381
117Aortic dissection (HP:0002647)1.81280500
118Striae distensae (HP:0001065)1.81223338
119Viral hepatitis (HP:0006562)1.80661568
120Joint hemorrhage (HP:0005261)1.80596583
121Abnormality of the common coagulation pathway (HP:0010990)1.78546085
122Granulocytopenia (HP:0001913)1.78471290
123Macroorchidism (HP:0000053)1.78183343
124Restrictive lung disease (HP:0002091)1.77112115
125Loss of speech (HP:0002371)1.76963566
126Abnormality of the peritoneum (HP:0002585)1.76672013
127Hemoptysis (HP:0002105)1.76544253
128Ulnar bowing (HP:0003031)1.76276254
129Hypertriglyceridemia (HP:0002155)1.75055848
130Increased variability in muscle fiber diameter (HP:0003557)1.74284463
131Gastrointestinal infarctions (HP:0005244)1.73374912
132Broad metatarsal (HP:0001783)1.72515843
133Fatigue (HP:0012378)1.72186414
134Facial diplegia (HP:0001349)1.72123201
135Bicuspid aortic valve (HP:0001647)1.71107408
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.71060023
137Spondylolisthesis (HP:0003302)1.69980328
138Subacute progressive viral hepatitis (HP:0006572)1.69106080
139Abnormality of the thoracic spine (HP:0100711)1.68625596
140Thoracic kyphosis (HP:0002942)1.68528792
141Polycythemia (HP:0001901)1.68301008
142Glomerulopathy (HP:0100820)1.68260401
143Increased IgM level (HP:0003496)1.66655401
144Neuronal loss in central nervous system (HP:0002529)1.65708727
145Hypochromic microcytic anemia (HP:0004840)1.65527462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.04548001
2TRIB33.95264584
3EEF2K3.40359788
4MAP4K13.36032079
5PKN23.15253975
6TTN2.90536650
7ERN12.85417568
8MAP3K102.63759011
9FGFR42.59866766
10EPHB12.33575256
11SIK12.08341481
12GRK62.07396486
13TYK21.94708328
14FGFR31.87350601
15ITK1.76648525
16STK101.72846903
17PTK61.70600853
18TGFBR21.70071360
19JAK11.67494009
20CAMK1D1.63974076
21MAP2K31.58884434
22ZAP701.58457811
23SIK21.57338243
24JAK31.56019340
25LRRK21.55989020
26SMG11.49159878
27BTK1.42905502
28RIPK11.40114067
29FGFR21.39886694
30CAMK1G1.38979736
31IRAK41.38368160
32HCK1.36102755
33TXK1.32470667
34CDK121.29530656
35TBK11.25401185
36CSK1.24894961
37DMPK1.24550177
38MAP3K111.24434998
39CSF1R1.21448986
40KSR21.20312038
41MAP3K11.19779142
42SIK31.17964104
43CDC42BPA1.12206303
44MAP3K71.09256942
45PDGFRA1.06648503
46TRPM71.05645486
47SYK1.05341691
48CAMKK11.03210281
49JAK21.01408730
50TAOK31.00492598
51BLK0.98652852
52IKBKE0.96420723
53FGR0.93751511
54FES0.92054503
55KIT0.90333042
56MAP3K140.85980937
57TAOK20.85954347
58PRKCH0.85557397
59PDGFRB0.84559471
60MAPK70.83326680
61LCK0.81623375
62FLT30.80720264
63TNK20.78239202
64CDK60.77240540
65RET0.76042070
66MAP3K60.75167475
67ALK0.73019605
68TAOK10.72746988
69STK380.72400708
70TEC0.71313958
71ICK0.70854329
72MAP3K130.68813379
73BMX0.67957290
74MTOR0.67379975
75PIM10.66477066
76CDK40.66254168
77PAK40.64087981
78MARK30.63743350
79MAPK40.63672431
80FYN0.60736467
81MAPK110.59432771
82MAP3K30.59176987
83CLK10.59117375
84RPS6KA40.58909644
85PRKAA20.58117979
86SGK30.57730035
87EPHA30.56006846
88MAPK120.54938274
89CAMKK20.54805635
90YES10.53902760
91NLK0.53755418
92MAPKAPK30.53688820
93PDK10.53039611
94TYRO30.52511661
95CHUK0.52469984
96PRKD10.51420135
97IKBKB0.50179860
98RPS6KB20.50054081
99TESK20.49260198
100UHMK10.48732353
101PRKCQ0.48619280
102MAP3K20.48117077
103HIPK20.47230230
104IRAK20.47176041
105MOS0.46824711
106IRAK30.46762075
107RIPK40.45969639
108STK40.45416916
109DYRK1B0.45274589
110RPS6KA20.44997918
111BMPR20.44068978
112NEK20.44042060
113MARK20.43499937
114STK110.43233358
115RPS6KA60.41458121
116PIK3CG0.40304538
117RPS6KC10.39685022
118RPS6KL10.39685022
119SGK20.39336874
120MELK0.39315843
121LYN0.39288156
122PDPK10.39011587
123FGFR10.38783528
124PRKD20.38410368
125CDK90.37122928
126PAK20.36648595

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.25177350
2Primary immunodeficiency_Homo sapiens_hsa053402.14770701
3Osteoclast differentiation_Homo sapiens_hsa043802.14479549
4B cell receptor signaling pathway_Homo sapiens_hsa046622.13525369
5Leishmaniasis_Homo sapiens_hsa051402.12016969
6Nitrogen metabolism_Homo sapiens_hsa009101.86683560
7Graft-versus-host disease_Homo sapiens_hsa053321.83847151
8Other glycan degradation_Homo sapiens_hsa005111.80091958
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78614602
10Allograft rejection_Homo sapiens_hsa053301.78233349
11T cell receptor signaling pathway_Homo sapiens_hsa046601.74109288
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74036795
13Autoimmune thyroid disease_Homo sapiens_hsa053201.67514100
14Chronic myeloid leukemia_Homo sapiens_hsa052201.65079536
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.61440238
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54741660
17Acute myeloid leukemia_Homo sapiens_hsa052211.54666548
18Lysine degradation_Homo sapiens_hsa003101.50432831
19Insulin resistance_Homo sapiens_hsa049311.47267813
20Toxoplasmosis_Homo sapiens_hsa051451.45383885
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.45183867
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43424682
23Caffeine metabolism_Homo sapiens_hsa002321.39881060
24Fatty acid degradation_Homo sapiens_hsa000711.37277095
25PPAR signaling pathway_Homo sapiens_hsa033201.35394734
26Viral myocarditis_Homo sapiens_hsa054161.29747338
27Platelet activation_Homo sapiens_hsa046111.28713331
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.27736036
29Complement and coagulation cascades_Homo sapiens_hsa046101.27539033
30Measles_Homo sapiens_hsa051621.25649610
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.20398761
32Pancreatic cancer_Homo sapiens_hsa052121.19651903
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19618423
34Type I diabetes mellitus_Homo sapiens_hsa049401.17937363
35Non-small cell lung cancer_Homo sapiens_hsa052231.17784425
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.17595507
37Antigen processing and presentation_Homo sapiens_hsa046121.16906959
38VEGF signaling pathway_Homo sapiens_hsa043701.15749930
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15381324
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13235453
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12931462
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12705963
43Chemokine signaling pathway_Homo sapiens_hsa040621.12165591
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09601173
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.08935096
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.07889080
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.06580523
48ABC transporters_Homo sapiens_hsa020101.05753305
49Hematopoietic cell lineage_Homo sapiens_hsa046401.05357100
50Arginine biosynthesis_Homo sapiens_hsa002201.04560900
51Small cell lung cancer_Homo sapiens_hsa052221.01137987
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01090906
53Fatty acid metabolism_Homo sapiens_hsa012120.98837977
54GnRH signaling pathway_Homo sapiens_hsa049120.98675167
55Hepatitis B_Homo sapiens_hsa051610.98625381
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98265268
57Apoptosis_Homo sapiens_hsa042100.96524196
58mTOR signaling pathway_Homo sapiens_hsa041500.95909956
59Shigellosis_Homo sapiens_hsa051310.95141202
60Choline metabolism in cancer_Homo sapiens_hsa052310.93531759
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92527160
62Tuberculosis_Homo sapiens_hsa051520.92523275
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91364287
64Inositol phosphate metabolism_Homo sapiens_hsa005620.90129584
65TNF signaling pathway_Homo sapiens_hsa046680.89439705
66Proteoglycans in cancer_Homo sapiens_hsa052050.88581943
67Insulin signaling pathway_Homo sapiens_hsa049100.88256405
68Focal adhesion_Homo sapiens_hsa045100.87881710
69Long-term potentiation_Homo sapiens_hsa047200.86974641
70Phagosome_Homo sapiens_hsa041450.84981815
71Notch signaling pathway_Homo sapiens_hsa043300.84342497
72Pertussis_Homo sapiens_hsa051330.83258844
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83212570
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.82683813
75Influenza A_Homo sapiens_hsa051640.81796418
76AMPK signaling pathway_Homo sapiens_hsa041520.80456642
77Amoebiasis_Homo sapiens_hsa051460.79686902
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78620699
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78325086
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77028033
81Prolactin signaling pathway_Homo sapiens_hsa049170.76651290
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.76488877
83ErbB signaling pathway_Homo sapiens_hsa040120.75577711
84Tryptophan metabolism_Homo sapiens_hsa003800.75365073
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73698664
86African trypanosomiasis_Homo sapiens_hsa051430.72830953
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72341310
88Asthma_Homo sapiens_hsa053100.70471017
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70453838
90Estrogen signaling pathway_Homo sapiens_hsa049150.70172576
91Colorectal cancer_Homo sapiens_hsa052100.68523183
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67863784
93HTLV-I infection_Homo sapiens_hsa051660.67038270
94FoxO signaling pathway_Homo sapiens_hsa040680.66855023
95Herpes simplex infection_Homo sapiens_hsa051680.66540684
96Renal cell carcinoma_Homo sapiens_hsa052110.66138925
97Lysosome_Homo sapiens_hsa041420.66108563
98Endometrial cancer_Homo sapiens_hsa052130.64209486
99MAPK signaling pathway_Homo sapiens_hsa040100.63576415
100Dorso-ventral axis formation_Homo sapiens_hsa043200.63486181
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.62941685
102Viral carcinogenesis_Homo sapiens_hsa052030.62861817
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62645521
104Hepatitis C_Homo sapiens_hsa051600.62538845
105Starch and sucrose metabolism_Homo sapiens_hsa005000.62195185
106Legionellosis_Homo sapiens_hsa051340.61404706
107Type II diabetes mellitus_Homo sapiens_hsa049300.61012051
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60693335
109Prion diseases_Homo sapiens_hsa050200.60417570
110Glycerolipid metabolism_Homo sapiens_hsa005610.60404204
111Propanoate metabolism_Homo sapiens_hsa006400.60297637
112Pentose phosphate pathway_Homo sapiens_hsa000300.60150085
113HIF-1 signaling pathway_Homo sapiens_hsa040660.59653148
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59434825
115Malaria_Homo sapiens_hsa051440.58810943
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58573002
117Rap1 signaling pathway_Homo sapiens_hsa040150.58536462
118Salmonella infection_Homo sapiens_hsa051320.58467404
119Prostate cancer_Homo sapiens_hsa052150.58411174
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57063409
121MicroRNAs in cancer_Homo sapiens_hsa052060.55504364
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54575316
123Glioma_Homo sapiens_hsa052140.53334078
124Carbon metabolism_Homo sapiens_hsa012000.52359270
125Adherens junction_Homo sapiens_hsa045200.52087317
126Fatty acid biosynthesis_Homo sapiens_hsa000610.51902940
127Thyroid cancer_Homo sapiens_hsa052160.50909254
128Epstein-Barr virus infection_Homo sapiens_hsa051690.50727477
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50648951
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.50414030
131Endocytosis_Homo sapiens_hsa041440.49735380

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