SUN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.87904618
2axonemal dynein complex assembly (GO:0070286)9.87483123
3epithelial cilium movement (GO:0003351)9.84730533
4cell-cell recognition (GO:0009988)9.83249844
5spermatid development (GO:0007286)9.23905996
6reproduction (GO:0000003)9.23729663
7motile cilium assembly (GO:0044458)9.09667574
8cilium movement (GO:0003341)8.17866563
9regulation of cilium movement (GO:0003352)7.86763587
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.54647575
11piRNA metabolic process (GO:0034587)7.53466960
12male meiosis (GO:0007140)7.27924239
13single fertilization (GO:0007338)7.25216949
14sperm capacitation (GO:0048240)7.00800303
15synaptonemal complex organization (GO:0070193)6.92844225
16synaptonemal complex assembly (GO:0007130)6.71760515
17organic cation transport (GO:0015695)6.53808088
18negative regulation of inclusion body assembly (GO:0090084)6.26535030
19spermatogenesis (GO:0007283)6.13933696
20male gamete generation (GO:0048232)6.11434343
21fertilization (GO:0009566)6.09680410
22microtubule depolymerization (GO:0007019)5.73403521
23gamete generation (GO:0007276)5.61512342
24regulation of inclusion body assembly (GO:0090083)5.26729447
25ventricular system development (GO:0021591)5.25230614
26behavioral response to nicotine (GO:0035095)5.23971470
27calcium ion-dependent exocytosis (GO:0017156)5.18558723
28germ cell development (GO:0007281)5.10732989
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.09272282
30DNA methylation involved in gamete generation (GO:0043046)4.87769961
31male meiosis I (GO:0007141)4.84693254
32response to pheromone (GO:0019236)4.82468701
33glycerol ether metabolic process (GO:0006662)4.71889656
34chromosome organization involved in meiosis (GO:0070192)4.65610760
35cell recognition (GO:0008037)4.65267114
36DNA deamination (GO:0045006)4.56907940
37regulation of microtubule-based movement (GO:0060632)4.55796886
38multicellular organismal reproductive process (GO:0048609)4.43094118
39left/right pattern formation (GO:0060972)4.35747404
40ether metabolic process (GO:0018904)4.34564946
41seminiferous tubule development (GO:0072520)4.24130738
42meiotic nuclear division (GO:0007126)4.21086966
43chromosome condensation (GO:0030261)4.20720289
44spermatid nucleus differentiation (GO:0007289)4.15284868
45DNA packaging (GO:0006323)3.98621749
46microtubule severing (GO:0051013)3.95585994
47carnitine transport (GO:0015879)3.91518250
48amino-acid betaine transport (GO:0015838)3.91518250
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88512738
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.84087185
51meiosis I (GO:0007127)3.84066326
52chaperone-mediated protein complex assembly (GO:0051131)3.80487580
53ATP synthesis coupled proton transport (GO:0015986)3.79027622
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79027622
55carnitine transmembrane transport (GO:1902603)3.68987259
56regulation of hippo signaling (GO:0035330)3.57402312
57sexual reproduction (GO:0019953)3.56834778
58multicellular organismal development (GO:0007275)3.55775038
59meiotic cell cycle (GO:0051321)3.55552861
60genitalia morphogenesis (GO:0035112)3.50170101
61water-soluble vitamin biosynthetic process (GO:0042364)3.50139394
62protein-cofactor linkage (GO:0018065)3.50008170
63alditol metabolic process (GO:0019400)3.45193487
64monoubiquitinated protein deubiquitination (GO:0035520)3.34460666
65rRNA modification (GO:0000154)3.33685736
66protein localization to cilium (GO:0061512)3.31466429
67L-fucose catabolic process (GO:0042355)3.31183059
68fucose catabolic process (GO:0019317)3.31183059
69L-fucose metabolic process (GO:0042354)3.31183059
70single strand break repair (GO:0000012)3.28468852
71positive regulation of prostaglandin secretion (GO:0032308)3.28182508
72polyol catabolic process (GO:0046174)3.26821881
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19623954
74nucleoside diphosphate phosphorylation (GO:0006165)3.17822136
75rRNA methylation (GO:0031167)3.15543602
76lactate metabolic process (GO:0006089)3.11207229
77maturation of 5.8S rRNA (GO:0000460)3.10584883
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.06015390
79protein polyglutamylation (GO:0018095)3.05899819
80glycerol metabolic process (GO:0006071)3.05155252
81pseudouridine synthesis (GO:0001522)3.05068156
82glycolytic process (GO:0006096)3.04146284
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.03336721
84NADH dehydrogenase complex assembly (GO:0010257)3.03336721
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03336721
86microtubule polymerization or depolymerization (GO:0031109)3.01202735
87nonmotile primary cilium assembly (GO:0035058)3.00851303
88quaternary ammonium group transport (GO:0015697)2.99739767
89regulation of spindle checkpoint (GO:0090231)2.98352595
90GTP biosynthetic process (GO:0006183)2.95682709
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92131566
92cellular ketone body metabolic process (GO:0046950)2.91157227
93preassembly of GPI anchor in ER membrane (GO:0016254)2.91076561
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.89548872
95negative regulation of telomere maintenance (GO:0032205)2.88523604
96protein refolding (GO:0042026)2.88158862
97respiratory chain complex IV assembly (GO:0008535)2.83924318
98kidney morphogenesis (GO:0060993)2.81724835
99reflex (GO:0060004)2.80413522
100phosphatidylinositol acyl-chain remodeling (GO:0036149)2.76735090
101intraciliary transport (GO:0042073)2.75708726
102primary amino compound metabolic process (GO:1901160)2.73763857
103axoneme assembly (GO:0035082)2.72991445
104indolalkylamine metabolic process (GO:0006586)2.72864491
105protein complex biogenesis (GO:0070271)2.71618991
106microtubule-based movement (GO:0007018)2.71483271
107centriole assembly (GO:0098534)2.71410494
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70858777
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70858777
110sequestering of actin monomers (GO:0042989)2.70362706
111synapsis (GO:0007129)2.70350331
112somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69838210
113somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69838210
114isotype switching (GO:0045190)2.69838210
115mitochondrial respiratory chain complex assembly (GO:0033108)2.69733542
116cilium organization (GO:0044782)2.69196557
117protein K11-linked deubiquitination (GO:0035871)2.67124631
118proteasome assembly (GO:0043248)2.66303815
119meiotic cell cycle process (GO:1903046)2.65865433
120kynurenine metabolic process (GO:0070189)2.65495353
121negative regulation of organelle assembly (GO:1902116)2.64738862
122cellular component assembly involved in morphogenesis (GO:0010927)2.64414592
123peptidyl-glutamic acid modification (GO:0018200)2.64206873
124regulation of mesoderm development (GO:2000380)2.63745915
125hydrogen ion transmembrane transport (GO:1902600)2.63501307
126mitotic sister chromatid cohesion (GO:0007064)2.63439467
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63103153
128positive regulation of fatty acid transport (GO:2000193)2.61854836
129neuronal action potential (GO:0019228)2.59553665
130electron transport chain (GO:0022900)2.59528022
131indole-containing compound catabolic process (GO:0042436)2.59416771
132indolalkylamine catabolic process (GO:0046218)2.59416771
133tryptophan catabolic process (GO:0006569)2.59416771
134cilium assembly (GO:0042384)2.58787311
135cilium morphogenesis (GO:0060271)2.58760590
136positive regulation of meiotic cell cycle (GO:0051446)2.58593284
137UTP biosynthetic process (GO:0006228)2.58415693
138ketone body metabolic process (GO:1902224)2.58169536
139proton transport (GO:0015992)2.56404674
140nucleus organization (GO:0006997)2.56035540
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55768504
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54873440
143regulation of mitotic spindle checkpoint (GO:1903504)2.54873440
144ubiquinone biosynthetic process (GO:0006744)2.54861569
145GPI anchor metabolic process (GO:0006505)2.54634861
146cornea development in camera-type eye (GO:0061303)2.54510007
147spinal cord motor neuron differentiation (GO:0021522)2.54297557
148tRNA processing (GO:0008033)2.54081871
149hydrogen transport (GO:0006818)2.53940708
150exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53765475
151negative regulation of mast cell activation (GO:0033004)2.52317718
152UTP metabolic process (GO:0046051)2.51748192
153auditory receptor cell stereocilium organization (GO:0060088)2.50127894
154ubiquinone metabolic process (GO:0006743)2.50071569
155sulfation (GO:0051923)2.49388459
156regulation of centriole replication (GO:0046599)2.49179119
157regulation of action potential (GO:0098900)2.47410287
158polyamine biosynthetic process (GO:0006596)2.46832535
159respiratory electron transport chain (GO:0022904)2.46736436
160L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46732175
161regulation of prostaglandin secretion (GO:0032306)2.45721738
162negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45503595
163somite rostral/caudal axis specification (GO:0032525)2.44745784
164positive regulation of icosanoid secretion (GO:0032305)2.44565635
165fructose metabolic process (GO:0006000)2.44456829
166centriole replication (GO:0007099)2.43258630
167somite development (GO:0061053)2.43042091
168nephron epithelium morphogenesis (GO:0072088)2.42101809
169nephron tubule morphogenesis (GO:0072078)2.42101809
170gene silencing by RNA (GO:0031047)2.41503519
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37079736
172fusion of sperm to egg plasma membrane (GO:0007342)13.6887900
173sperm motility (GO:0030317)12.9538382
174cell wall macromolecule metabolic process (GO:0044036)12.8360167
175cell wall macromolecule catabolic process (GO:0016998)12.8360167
176acrosome reaction (GO:0007340)11.1156814
177sperm-egg recognition (GO:0035036)11.0252278
178acrosome assembly (GO:0001675)10.9276260
179multicellular organism reproduction (GO:0032504)10.8569963
180cilium or flagellum-dependent cell motility (GO:0001539)10.7772174
181plasma membrane fusion (GO:0045026)10.3962149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.21830247
2EZH2_22144423_ChIP-Seq_EOC_Human4.12193811
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.49025770
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24417446
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.02388963
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77968522
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75341700
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65246882
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.61424515
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59291318
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35922641
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34444670
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.21235642
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10977347
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08044758
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06425579
17IRF1_19129219_ChIP-ChIP_H3396_Human2.05719703
18VDR_22108803_ChIP-Seq_LS180_Human2.01552666
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.01357115
20ZNF274_21170338_ChIP-Seq_K562_Hela1.96342060
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.95490511
22MYC_18940864_ChIP-ChIP_HL60_Human1.94196825
23FUS_26573619_Chip-Seq_HEK293_Human1.92559144
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91068104
25GBX2_23144817_ChIP-Seq_PC3_Human1.84626137
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.81766304
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80998775
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79700271
29ER_23166858_ChIP-Seq_MCF-7_Human1.75053366
30STAT1_17558387_ChIP-Seq_HELA_Human1.74920122
31EWS_26573619_Chip-Seq_HEK293_Human1.73240623
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72078109
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71885374
34TP53_22573176_ChIP-Seq_HFKS_Human1.71779944
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71222756
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70916756
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68491091
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.67669471
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.66189937
40P300_19829295_ChIP-Seq_ESCs_Human1.65993249
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63888400
42* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63234133
43IGF1R_20145208_ChIP-Seq_DFB_Human1.63044035
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.58951479
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56621747
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54897564
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.52459405
48KDM2B_26808549_Chip-Seq_REH_Human1.52441306
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.50691130
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.49979515
51* GATA3_21867929_ChIP-Seq_CD8_Mouse1.47477813
52FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47376805
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.46739011
54* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46008548
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45834774
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44416256
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43526724
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42071047
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41852618
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40193917
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39901576
62CBP_20019798_ChIP-Seq_JUKART_Human1.38826879
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38826879
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37127879
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.34850949
66VDR_23849224_ChIP-Seq_CD4+_Human1.34446989
67AR_25329375_ChIP-Seq_VCAP_Human1.33385789
68NCOR_22424771_ChIP-Seq_293T_Human1.33078855
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.32807270
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32807270
71HOXB7_26014856_ChIP-Seq_BT474_Human1.32595499
72GF1_26923725_Chip-Seq_HPCs_Mouse1.32238529
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31961951
74RNF2_27304074_Chip-Seq_NSC_Mouse1.31665584
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31320119
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31178660
77ELK1_19687146_ChIP-ChIP_HELA_Human1.30663033
78* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30095619
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29238372
80P53_21459846_ChIP-Seq_SAOS-2_Human1.28853856
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.28684926
82* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28061675
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27185088
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26632364
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26632364
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.25608240
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.24483764
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24308814
89BCAT_22108803_ChIP-Seq_LS180_Human1.22684050
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21364046
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21222312
92ERA_21632823_ChIP-Seq_H3396_Human1.21139569
93SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19932460
94FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19832254
95REST_21632747_ChIP-Seq_MESCs_Mouse1.19131473
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16864264
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.16649657
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16406179
99TCF4_22108803_ChIP-Seq_LS180_Human1.15933668
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.14648726
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14224454
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.13555205
103NANOG_19829295_ChIP-Seq_ESCs_Human1.13215576
104SOX2_19829295_ChIP-Seq_ESCs_Human1.13215576
105P53_22387025_ChIP-Seq_ESCs_Mouse1.12395298
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12253013
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.11877686
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.11494180
109P300_18555785_Chip-Seq_ESCs_Mouse1.11165588
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.11039489
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10973353
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10193952
113AR_20517297_ChIP-Seq_VCAP_Human1.09659825
114* MYC_19829295_ChIP-Seq_ESCs_Human1.09544954
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09236831
116AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09123266
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08851855
118ESET_19884257_ChIP-Seq_ESCs_Mouse1.08719415
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07476972
120EED_16625203_ChIP-ChIP_MESCs_Mouse1.06891259
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06231915
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.05552571
123SPI1_26923725_Chip-Seq_HPCs_Mouse1.04800873
124REST_18959480_ChIP-ChIP_MESCs_Mouse1.04758207
125ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04716320
126NANOG_20526341_ChIP-Seq_ESCs_Human1.04180536
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03995659
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03894297
129FOXH1_21741376_ChIP-Seq_EPCs_Human1.03846195
130RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03026547
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.02770711
132PU1_27457419_Chip-Seq_LIVER_Mouse1.02235158
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01743678
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01736579
135TAF2_19829295_ChIP-Seq_ESCs_Human1.01559240
136RUNX2_22187159_ChIP-Seq_PCA_Human1.01280164
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00965507
138MYC_27129775_Chip-Seq_CORNEA_Mouse1.00696121
139TAF15_26573619_Chip-Seq_HEK293_Human1.00289709
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00271430
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00170252
142TCF4_23295773_ChIP-Seq_U87_Human1.00031618
143ERG_20517297_ChIP-Seq_VCAP_Human0.99873931
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99797336
145NFYB_21822215_ChIP-Seq_K562_Human0.99603440
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.99279250
147PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99265376
148STAT3_23295773_ChIP-Seq_U87_Human0.98143422
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97532270
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97247591
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.97088262
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96615118
153OCT4_20526341_ChIP-Seq_ESCs_Human0.96596589
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96513305
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.96283929
156TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95640494
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95612628
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95195413
159SMAD4_21799915_ChIP-Seq_A2780_Human0.94692881
160RARA_24833708_ChIP-Seq_LIVER_Mouse0.93576878
161FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93573524
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93551396
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92943932
164SOX2_21211035_ChIP-Seq_LN229_Human0.92934161
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92698933
166CTCF_18555785_Chip-Seq_ESCs_Mouse0.92274205
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91954378
168EZH2_27294783_Chip-Seq_ESCs_Mouse0.91400895
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.90747238
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90684097
171ZFX_18555785_Chip-Seq_ESCs_Mouse0.90058691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.58504140
2MP0001929_abnormal_gametogenesis5.09843781
3MP0002102_abnormal_ear_morphology4.34156083
4MP0008877_abnormal_DNA_methylation3.91551825
5MP0001968_abnormal_touch/_nociception3.23770742
6MP0005670_abnormal_white_adipose3.21085700
7MP0002210_abnormal_sex_determination3.19625605
8MP0002161_abnormal_fertility/fecundity3.00301127
9MP0001145_abnormal_male_reproductive2.67176158
10MP0006292_abnormal_olfactory_placode2.56708612
11MP0000653_abnormal_sex_gland2.31791510
12MP0002653_abnormal_ependyma_morphology2.31287959
13MP0002736_abnormal_nociception_after2.29010361
14MP0001529_abnormal_vocalization2.28982940
15MP0005084_abnormal_gallbladder_morpholo2.12940764
16MP0003646_muscle_fatigue2.10093227
17MP0000427_abnormal_hair_cycle2.08117680
18MP0002139_abnormal_hepatobiliary_system2.05665321
19MP0005410_abnormal_fertilization15.2061065
20MP0005623_abnormal_meninges_morphology1.85470707
21MP0004885_abnormal_endolymph1.82837276
22MP0003880_abnormal_central_pattern1.81765629
23MP0003787_abnormal_imprinting1.75031371
24MP0001986_abnormal_taste_sensitivity1.72711402
25MP0008872_abnormal_physiological_respon1.72656537
26MP0009745_abnormal_behavioral_response1.69700002
27MP0004142_abnormal_muscle_tone1.68202285
28MP0005360_urolithiasis1.66741840
29MP0003136_yellow_coat_color1.63026957
30MP0003718_maternal_effect1.62791432
31MP0004133_heterotaxia1.62554570
32MP0002909_abnormal_adrenal_gland1.61477316
33MP0000647_abnormal_sebaceous_gland1.58732830
34MP0001485_abnormal_pinna_reflex1.58705087
35MP0004233_abnormal_muscle_weight1.55616619
36MP0006072_abnormal_retinal_apoptosis1.53896389
37MP0006276_abnormal_autonomic_nervous1.52173445
38MP0001765_abnormal_ion_homeostasis1.51610436
39MP0002272_abnormal_nervous_system1.50267702
40MP0005645_abnormal_hypothalamus_physiol1.48961914
41MP0001905_abnormal_dopamine_level1.48366185
42MP0005646_abnormal_pituitary_gland1.48111067
43MP0000631_abnormal_neuroendocrine_gland1.46312227
44MP0001919_abnormal_reproductive_system1.39006518
45MP0004742_abnormal_vestibular_system1.38277722
46MP0000049_abnormal_middle_ear1.36160320
47MP0002735_abnormal_chemical_nociception1.33444953
48MP0002160_abnormal_reproductive_system1.31329568
49MP0005365_abnormal_bile_salt1.31329506
50MP0005085_abnormal_gallbladder_physiolo1.29005429
51MP0002837_dystrophic_cardiac_calcinosis1.28734329
52MP0008875_abnormal_xenobiotic_pharmacok1.27874297
53MP0002557_abnormal_social/conspecific_i1.25708933
54MP0002876_abnormal_thyroid_physiology1.23061386
55MP0005386_behavior/neurological_phenoty1.22863808
56MP0004924_abnormal_behavior1.22863808
57MP0002572_abnormal_emotion/affect_behav1.21158506
58MP0005377_hearing/vestibular/ear_phenot1.20617172
59MP0003878_abnormal_ear_physiology1.20617172
60MP0002822_catalepsy1.20363558
61MP0002938_white_spotting1.19997456
62MP0004036_abnormal_muscle_relaxation1.18992525
63MP0005451_abnormal_body_composition1.16224569
64MP0003119_abnormal_digestive_system1.16051920
65MP0001440_abnormal_grooming_behavior1.15203792
66MP0004019_abnormal_vitamin_homeostasis1.13975029
67MP0004147_increased_porphyrin_level1.12377850
68MP0000026_abnormal_inner_ear1.08192912
69MP0001486_abnormal_startle_reflex1.07966916
70MP0001984_abnormal_olfaction1.07436703
71MP0005647_abnormal_sex_gland1.06514374
72MP0004145_abnormal_muscle_electrophysio1.05931893
73MP0003252_abnormal_bile_duct1.03678718
74MP0000383_abnormal_hair_follicle1.03493427
75MP0002733_abnormal_thermal_nociception1.02614947
76MP0001970_abnormal_pain_threshold1.02361194
77MP0003011_delayed_dark_adaptation1.02076652
78MP0005187_abnormal_penis_morphology1.01097331
79MP0002067_abnormal_sensory_capabilities1.01088068
80MP0004084_abnormal_cardiac_muscle1.00774889
81MP0005636_abnormal_mineral_homeostasis1.00016054
82MP0001501_abnormal_sleep_pattern0.98861656
83MP0004043_abnormal_pH_regulation0.98755515
84MP0002064_seizures0.97729889
85MP0005666_abnormal_adipose_tissue0.97437933
86MP0002751_abnormal_autonomic_nervous0.97110995
87MP0000778_abnormal_nervous_system0.96931304
88MP0008995_early_reproductive_senescence0.96708364
89MP0006036_abnormal_mitochondrial_physio0.94517799
90MP0001963_abnormal_hearing_physiology0.94220228
91MP0001764_abnormal_homeostasis0.92343798
92MP0003937_abnormal_limbs/digits/tail_de0.92164623
93MP0008789_abnormal_olfactory_epithelium0.91692497
94MP0003635_abnormal_synaptic_transmissio0.91427480
95MP0002234_abnormal_pharynx_morphology0.90307624
96MP0002063_abnormal_learning/memory/cond0.89988895
97MP0003283_abnormal_digestive_organ0.89737396
98MP0005332_abnormal_amino_acid0.88173132
99MP0005195_abnormal_posterior_eye0.85451752
100MP0002734_abnormal_mechanical_nocicepti0.84006496
101MP0009046_muscle_twitch0.83169484
102MP0002269_muscular_atrophy0.82922044
103MP0003121_genomic_imprinting0.82498433
104MP0002282_abnormal_trachea_morphology0.81688560
105MP0009379_abnormal_foot_pigmentation0.81667293
106MP0002638_abnormal_pupillary_reflex0.81231612
107MP0002184_abnormal_innervation0.79855104
108MP0002752_abnormal_somatic_nervous0.79601368
109MP0008058_abnormal_DNA_repair0.78880379
110MP0005448_abnormal_energy_balance0.75704004
111MP0000751_myopathy0.68377570
112MP0005389_reproductive_system_phenotype0.66671253
113MP0002971_abnormal_brown_adipose0.65268023
114MP0010329_abnormal_lipoprotein_level0.64153647
115MP0004130_abnormal_muscle_cell0.63914593
116MP0003806_abnormal_nucleotide_metabolis0.60216885
117MP0005319_abnormal_enzyme/_coenzyme0.60049447
118MP0002928_abnormal_bile_duct0.59765208
119MP0004215_abnormal_myocardial_fiber0.55551114
120MP0002118_abnormal_lipid_homeostasis0.54490770
121MP0009115_abnormal_fat_cell0.54191408
122MP0008961_abnormal_basal_metabolism0.50210412
123MP0010094_abnormal_chromosome_stability0.46926714
124MP0001324_abnormal_eye_pigmentation0.45384108
125MP0005551_abnormal_eye_electrophysiolog0.44997214
126MP0005584_abnormal_enzyme/coenzyme_acti0.44102531
127MP0004087_abnormal_muscle_fiber0.43343977
128MP0002138_abnormal_hepatobiliary_system0.42158710
129MP0005167_abnormal_blood-brain_barrier0.41882725
130MP0005253_abnormal_eye_physiology0.40608615
131MP0009643_abnormal_urine_homeostasis0.40525146
132MP0006035_abnormal_mitochondrial_morpho0.40277433
133MP0003633_abnormal_nervous_system0.40196481
134MP0005535_abnormal_body_temperature0.39216115
135MP0001727_abnormal_embryo_implantation0.38283394
136MP0010630_abnormal_cardiac_muscle0.37745866
137MP0003329_amyloid_beta_deposits0.36992544
138MP0003879_abnormal_hair_cell0.35600909
139MP0003699_abnormal_female_reproductive0.35144664
140MP0004085_abnormal_heartbeat0.34539545
141MP0005375_adipose_tissue_phenotype0.34488326
142MP0000358_abnormal_cell_content/0.33428233
143MP0005083_abnormal_biliary_tract0.31644104
144MP0005620_abnormal_muscle_contractility0.31070914
145MP0000609_abnormal_liver_physiology0.29779921
146MP0003115_abnormal_respiratory_system0.29371643
147MP0005330_cardiomyopathy0.28436371
148MP0009697_abnormal_copulation0.27676190
149MP0000569_abnormal_digit_pigmentation0.26625382
150MP0001293_anophthalmia0.26179493
151MP0003786_premature_aging0.25550171
152MP0003195_calcinosis0.25162058
153MP0009642_abnormal_blood_homeostasis0.24946258
154MP0002127_abnormal_cardiovascular_syste0.23547647
155MP0000749_muscle_degeneration0.23424569
156MP0006138_congestive_heart_failure0.23336453
157MP0003950_abnormal_plasma_membrane0.23147243
158MP0005423_abnormal_somatic_nervous0.23122683
159MP0003186_abnormal_redox_activity0.22865838
160MP0003953_abnormal_hormone_level0.22663767
161MP0002078_abnormal_glucose_homeostasis0.22232901
162MP0005385_cardiovascular_system_phenoty0.21591591
163MP0001544_abnormal_cardiovascular_syste0.21591591
164MP0005391_vision/eye_phenotype0.21225362
165MP0002106_abnormal_muscle_physiology0.20899029
166MP0000462_abnormal_digestive_system0.20759033
167MP0009278_abnormal_bone_marrow0.20392645

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34781212
2Abnormal respiratory motile cilium morphology (HP:0005938)8.99776241
3Abnormal respiratory epithelium morphology (HP:0012253)8.99776241
4Abnormal ciliary motility (HP:0012262)7.57693011
5Rhinitis (HP:0012384)7.46149979
6Chronic bronchitis (HP:0004469)7.10773202
7Nasal polyposis (HP:0100582)6.32173403
8Infertility (HP:0000789)6.29475060
9Abnormality of the nasal mucosa (HP:0000433)5.22157052
10Bronchiectasis (HP:0002110)4.41546227
11Bronchitis (HP:0012387)4.37515280
12Male infertility (HP:0003251)4.09450489
13Pancreatic cysts (HP:0001737)3.95838199
14True hermaphroditism (HP:0010459)3.83418031
15Nephronophthisis (HP:0000090)3.80402401
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50622016
17Abnormality of alanine metabolism (HP:0010916)3.50622016
18Hyperalaninemia (HP:0003348)3.50622016
19Congenital stationary night blindness (HP:0007642)3.50514333
20Pancreatic fibrosis (HP:0100732)3.49712442
21Type II lissencephaly (HP:0007260)3.47278972
22Abnormal spermatogenesis (HP:0008669)3.43794824
23Recurrent sinusitis (HP:0011108)3.30556513
24Recurrent otitis media (HP:0000403)3.13778267
25Chronic hepatic failure (HP:0100626)3.07559070
26Abnormality of the renal medulla (HP:0100957)2.99062271
27Tubulointerstitial nephritis (HP:0001970)2.89777463
28Pendular nystagmus (HP:0012043)2.87874250
29Limb dystonia (HP:0002451)2.78943296
30Attenuation of retinal blood vessels (HP:0007843)2.67930302
31Abnormal rod and cone electroretinograms (HP:0008323)2.64557805
32Acute necrotizing encephalopathy (HP:0006965)2.59859235
33Recurrent bronchitis (HP:0002837)2.55343332
34Bilateral microphthalmos (HP:0007633)2.49310389
35Concave nail (HP:0001598)2.41830985
36Azoospermia (HP:0000027)2.36816880
37Tubulointerstitial abnormality (HP:0001969)2.35897719
38Lissencephaly (HP:0001339)2.35806241
39Medial flaring of the eyebrow (HP:0010747)2.35785945
40Impulsivity (HP:0100710)2.35601743
41Abnormal number of erythroid precursors (HP:0012131)2.34599331
42Gonadotropin excess (HP:0000837)2.33643721
43Increased CSF lactate (HP:0002490)2.32775457
44Mitochondrial inheritance (HP:0001427)2.29534790
45Tubular atrophy (HP:0000092)2.27782427
46Sclerocornea (HP:0000647)2.25627795
47Abolished electroretinogram (ERG) (HP:0000550)2.23659587
48Hypomagnesemia (HP:0002917)2.18692456
49Molar tooth sign on MRI (HP:0002419)2.17717071
50Abnormality of midbrain morphology (HP:0002418)2.17717071
51Abnormality of the renal cortex (HP:0011035)2.17714201
52Increased corneal curvature (HP:0100692)2.16855724
53Keratoconus (HP:0000563)2.16855724
543-Methylglutaconic aciduria (HP:0003535)2.14976419
55Abnormal mitochondria in muscle tissue (HP:0008316)2.14888185
56Acute encephalopathy (HP:0006846)2.14178367
57Male pseudohermaphroditism (HP:0000037)2.14034364
58Hyperventilation (HP:0002883)2.12326782
59Hyperglycinuria (HP:0003108)2.11186385
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11003877
61Progressive macrocephaly (HP:0004481)2.09979034
62Abnormality of the pons (HP:0007361)2.09667445
63Inability to walk (HP:0002540)2.08531949
64Optic disc pallor (HP:0000543)2.08315994
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07386783
66Hepatocellular necrosis (HP:0001404)2.05564816
67Abnormal gallbladder physiology (HP:0012438)2.05056434
68Cholecystitis (HP:0001082)2.05056434
69Abnormality of cells of the erythroid lineage (HP:0012130)2.03336462
70Abnormality of renal excretion (HP:0011036)2.01810931
71Bony spicule pigmentary retinopathy (HP:0007737)2.01285753
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3726953
73Dynein arm defect of respiratory motile cilia (HP:0012255)13.2441115
74Absent/shortened dynein arms (HP:0200106)13.2441115
75Patellar aplasia (HP:0006443)1.96206139
76Anencephaly (HP:0002323)1.95943194
77Hypoplasia of the pons (HP:0012110)1.95484216
78Increased serum lactate (HP:0002151)1.94811859
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.91281048
80Nephrogenic diabetes insipidus (HP:0009806)1.91044105
81Aplasia/Hypoplasia of the patella (HP:0006498)1.90469095
82Decreased circulating renin level (HP:0003351)1.89913513
83Bundle branch block (HP:0011710)1.89743270
84Methylmalonic aciduria (HP:0012120)1.89577406
85Methylmalonic acidemia (HP:0002912)1.89245579
86Severe muscular hypotonia (HP:0006829)1.88223287
87Renal cortical cysts (HP:0000803)1.88166457
88Abnormal drinking behavior (HP:0030082)1.86836740
89Polydipsia (HP:0001959)1.86836740
90Stage 5 chronic kidney disease (HP:0003774)1.85639384
91Stomatitis (HP:0010280)1.85510139
92Chorioretinal atrophy (HP:0000533)1.83476580
93Optic nerve hypoplasia (HP:0000609)1.82910818
94Hepatic necrosis (HP:0002605)1.82364810
95Occipital encephalocele (HP:0002085)1.82126244
96Aplasia/hypoplasia of the uterus (HP:0008684)1.81861438
97Asymmetric septal hypertrophy (HP:0001670)1.81605299
98Furrowed tongue (HP:0000221)1.81218619
99Congenital, generalized hypertrichosis (HP:0004540)1.81125063
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.80353802
101Abnormality of glycine metabolism (HP:0010895)1.79919242
102Abnormality of serine family amino acid metabolism (HP:0010894)1.79919242
103Tubulointerstitial fibrosis (HP:0005576)1.78985453
104Amelogenesis imperfecta (HP:0000705)1.78023486
105Abnormality of dental color (HP:0011073)1.77598995
106Aplasia/Hypoplasia of the fovea (HP:0008060)1.77119307
107Hypoplasia of the fovea (HP:0007750)1.77119307
108Abnormality of the lower motor neuron (HP:0002366)1.76970024
109Tetany (HP:0001281)1.76701450
110Hypothermia (HP:0002045)1.76163389
111Hydroxyprolinuria (HP:0003080)1.75903869
112Abnormality of proline metabolism (HP:0010907)1.75903869
113Retinal dysplasia (HP:0007973)1.75366865
114Myoglobinuria (HP:0002913)1.75245020
115Vaginal atresia (HP:0000148)1.75174789
116Progressive inability to walk (HP:0002505)1.75167420
117Large for gestational age (HP:0001520)1.74961951
118Vascular calcification (HP:0004934)1.73156278
119Spastic tetraparesis (HP:0001285)1.73035864
120Abnormal urine output (HP:0012590)1.71917835
121Exercise-induced myalgia (HP:0003738)1.71087140
122Postaxial foot polydactyly (HP:0001830)1.67606069
123Dyschromatopsia (HP:0007641)1.65697435
124Decreased central vision (HP:0007663)1.54059581
125Congenital hepatic fibrosis (HP:0002612)1.53768301
126Cardiovascular calcification (HP:0011915)1.53277650
127Impaired proprioception (HP:0010831)1.51691484
128Hyporeflexia of lower limbs (HP:0002600)1.51467960
129Fibular hypoplasia (HP:0003038)1.50753009
130Abnormality of renal resorption (HP:0011038)1.48087207
131Median cleft lip (HP:0000161)1.44021466
132Facial cleft (HP:0002006)1.41354105
133Hemorrhage of the eye (HP:0011885)1.40450178
134Hypercholesterolemia (HP:0003124)1.38256251
135Heterotopia (HP:0002282)1.38115743
136Abnormality of molar morphology (HP:0011070)1.37466359
137Abnormality of molar (HP:0011077)1.37466359
138Short ribs (HP:0000773)1.37249336
139Abnormality of the dental root (HP:0006486)1.37059664
140Taurodontia (HP:0000679)1.37059664
141Abnormality of permanent molar morphology (HP:0011071)1.37059664
142Double outlet right ventricle (HP:0001719)1.36075532
143Congenital malformation of the right heart (HP:0011723)1.36075532
144Rhabdomyolysis (HP:0003201)1.34873073
145Ketosis (HP:0001946)1.34569851
146Congenital primary aphakia (HP:0007707)1.32555073
147Hemiparesis (HP:0001269)1.32491585
148Gait imbalance (HP:0002141)1.32341160
149Polyuria (HP:0000103)1.32168330
150Chronic sinusitis (HP:0011109)1.31248318
151Abnormal biliary tract physiology (HP:0012439)1.31004444
152Bile duct proliferation (HP:0001408)1.31004444
153Facial shape deformation (HP:0011334)1.30535449
154Potter facies (HP:0002009)1.30535449
155Postaxial hand polydactyly (HP:0001162)1.30466817
156Oculomotor apraxia (HP:0000657)1.30333701
157Constricted visual fields (HP:0001133)1.28855001
158Exercise-induced muscle cramps (HP:0003710)1.27282546
159Retinal atrophy (HP:0001105)1.27122759
160Amyotrophic lateral sclerosis (HP:0007354)1.27077192
161Deformed sella turcica (HP:0002681)1.26529337
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.25336667
163Difficulty climbing stairs (HP:0003551)1.24650216
164Abnormality of the dental pulp (HP:0006479)1.24448380
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.24315397
166Cerebellar dysplasia (HP:0007033)1.23369765
167Aplasia/Hypoplasia of the lens (HP:0008063)1.23326138
168Neurofibrillary tangles (HP:0002185)1.23215262
169Bell-shaped thorax (HP:0001591)1.20363683
170Renal dysplasia (HP:0000110)1.19434136
171Choroideremia (HP:0001139)1.17409480
172Gout (HP:0001997)1.16945781
173Cystic liver disease (HP:0006706)1.16752260
174Short thorax (HP:0010306)1.16567426
175Generalized muscle weakness (HP:0003324)1.15701045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.61716508
2PDK48.61716508
3PDK25.52685625
4TESK15.07787654
5TLK14.77676358
6PRKD34.41251680
7ICK3.85446079
8ZAK3.45736113
9ADRBK23.12312162
10MAP4K23.08366860
11WNK42.70764493
12BMPR1B2.64549462
13STK392.43745763
14TNIK2.40911929
15FRK2.29757977
16PTK2B2.22140766
17PBK2.09830243
18GRK12.07351344
19CASK1.92670153
20INSRR1.76621611
21MST41.76089538
22MAP3K41.74540001
23STK381.64392330
24PNCK1.44227491
25MAPK131.43900480
26MARK11.41925954
27LMTK21.37221913
28DYRK21.37219611
29DAPK21.29997196
30NEK21.29965147
31DYRK1B1.29313692
32MAP2K71.25218337
33NUAK11.22944933
34VRK11.21975081
35TSSK61.21664362
36MKNK21.17400263
37PDK11.16998319
38VRK21.15738692
39PRKCI1.10555926
40PLK21.08468682
41ADRBK11.07818970
42CAMKK21.07274943
43STK161.02287362
44PAK61.02220074
45WNK10.97675718
46MAPK150.97417909
47NME10.95343591
48TGFBR10.94370131
49RPS6KA50.93633771
50CCNB10.91944963
51NEK10.91922274
52IRAK10.90394723
53PRKCE0.88815914
54TXK0.88295840
55TAOK30.80828337
56SRPK10.80152480
57TTK0.79931770
58RPS6KA40.78301280
59PDPK10.77736310
60FLT30.75205034
61TRIM280.73169935
62PINK10.69681939
63ACVR1B0.64275855
64CAMK1G0.63859110
65MKNK10.63214333
66TYRO30.62235798
67PLK30.61825368
68PAK30.61619588
69PASK0.60457272
70STK38L0.60030129
71CHEK20.54986557
72MAP2K60.53589726
73CDK190.53056113
74PLK40.52790327
75NTRK20.52095318
76CSNK1G20.48836137
77TNK20.47696927
78MAP3K90.46032143
79BCR0.45917994
80BCKDK0.45135420
81DYRK30.43609348
82WNK30.43601293
83CDK80.43349016
84IRAK20.43164230
85MAP3K120.41270927
86MAPKAPK50.41071421
87CSNK1G30.40306076
88STK30.40176575
89EPHB20.38458808
90ERBB20.37796137
91PHKG10.37660488
92PHKG20.37660488
93PRKAA10.36675674
94CSNK1G10.36073431
95SIK20.35873268
96AURKB0.35845486
97RIPK10.34444366
98TTN0.33943163
99CAMK40.33640627
100ABL20.33581482
101ERBB30.33260403
102GRK70.32927342
103CAMK10.32718422
104PRKCG0.31561238
105RIPK40.31064739
106KIT0.30009901
107ATR0.29732933
108MAP2K20.29722872
109ATM0.28713620
110CHEK10.28511220
111MUSK0.28323399
112CAMKK10.27028761
113EIF2AK20.26208485
114CAMK2B0.25313861
115PLK10.25282034
116PRKCZ0.24992600
117CSNK1A10.24987454
118MTOR0.24772156
119WEE10.24752928
120BRAF0.24667803
121PRKG20.24089028
122CSNK1E0.23601164
123IRAK40.21740082
124PKN10.19085771
125PRKACG0.18163486
126BUB10.17689125
127MYLK0.17558912
128PAK10.17419658
129EEF2K0.16608968
130OBSCN0.14593757
131PIK3CG0.14230922
132PRKCQ0.12773895
133NEK60.12077219
134EPHB10.11570168
135TESK20.11311069
136RPS6KB10.10880609
137CSNK1D0.10600036
138RPS6KA10.10474187
139CAMK2A0.09352627
140CSNK2A10.09034140
141PRKG10.09021862
142CLK10.08717912
143MARK30.08411211
144PTK60.08309120
145TIE10.08013624
146PRKCA0.07813074
147STK110.07242772
148PRKACA0.06901714
149OXSR10.06889477
150YES10.05854082
151PRKCD0.05446782
152CDC70.05225770
153EGFR0.05206775
154PRKACB0.04837930
155CSNK2A20.03989333
156PRKDC0.03630219
157PAK20.03560850
158CAMK1D0.02751922
159BRSK20.02582850
160MST1R0.02565276
161PRKAA20.02423235
162PAK40.02345387
163PRKCB0.02165810
164CDK40.01981075
165MAP3K50.01777378
166GSK3B0.01550478
167RPS6KA30.01504791
168FGFR40.01478096
169AURKA-0.0070308

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.89330368
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.79763848
3Propanoate metabolism_Homo sapiens_hsa006403.78627220
4Fatty acid biosynthesis_Homo sapiens_hsa000613.55740987
5Vitamin B6 metabolism_Homo sapiens_hsa007503.17858776
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.91281697
7Fatty acid degradation_Homo sapiens_hsa000712.59467883
8Ribosome_Homo sapiens_hsa030102.36205200
9Phototransduction_Homo sapiens_hsa047442.35216619
10PPAR signaling pathway_Homo sapiens_hsa033202.27425142
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22804183
12Linoleic acid metabolism_Homo sapiens_hsa005912.18949445
13Fatty acid metabolism_Homo sapiens_hsa012122.18866992
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14374258
15Glucagon signaling pathway_Homo sapiens_hsa049222.13184422
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08545660
17Selenocompound metabolism_Homo sapiens_hsa004502.06907568
18Protein export_Homo sapiens_hsa030602.03491876
19RNA polymerase_Homo sapiens_hsa030202.03442895
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.02901091
21Carbon metabolism_Homo sapiens_hsa012001.98446194
22Nicotine addiction_Homo sapiens_hsa050331.96539338
23Glycerolipid metabolism_Homo sapiens_hsa005611.93728430
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89414021
25Cardiac muscle contraction_Homo sapiens_hsa042601.89233966
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88538565
27Sulfur relay system_Homo sapiens_hsa041221.85674413
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.81812871
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77998275
30Pentose phosphate pathway_Homo sapiens_hsa000301.76946228
31Proteasome_Homo sapiens_hsa030501.75017244
32One carbon pool by folate_Homo sapiens_hsa006701.68656387
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.62124192
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56446663
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53665223
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51570508
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48757671
38Huntingtons disease_Homo sapiens_hsa050161.48721955
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47841328
40RNA degradation_Homo sapiens_hsa030181.47321167
41Basal transcription factors_Homo sapiens_hsa030221.46556262
42Caffeine metabolism_Homo sapiens_hsa002321.44906911
43Homologous recombination_Homo sapiens_hsa034401.41351536
44Bile secretion_Homo sapiens_hsa049761.40596384
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39671480
46Olfactory transduction_Homo sapiens_hsa047401.37540906
47Fructose and mannose metabolism_Homo sapiens_hsa000511.33634868
48Fat digestion and absorption_Homo sapiens_hsa049751.33083241
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31176970
50Dorso-ventral axis formation_Homo sapiens_hsa043201.30202125
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29260473
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27372414
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25786317
54Biosynthesis of amino acids_Homo sapiens_hsa012301.22759536
55Chemical carcinogenesis_Homo sapiens_hsa052041.22651766
56Glycerophospholipid metabolism_Homo sapiens_hsa005641.21426424
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14769370
58Mineral absorption_Homo sapiens_hsa049781.14327317
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.09693248
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09039868
61Glutathione metabolism_Homo sapiens_hsa004801.08925700
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.08316330
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07753702
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05480738
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03919743
66Morphine addiction_Homo sapiens_hsa050321.03773258
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02212341
68Peroxisome_Homo sapiens_hsa041461.01762192
69Pyrimidine metabolism_Homo sapiens_hsa002401.01028215
70Oocyte meiosis_Homo sapiens_hsa041140.98802135
71Tryptophan metabolism_Homo sapiens_hsa003800.95888100
72Butanoate metabolism_Homo sapiens_hsa006500.94945474
73ABC transporters_Homo sapiens_hsa020100.93129560
74RNA transport_Homo sapiens_hsa030130.88343779
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87180142
76Nucleotide excision repair_Homo sapiens_hsa034200.86313217
77Steroid biosynthesis_Homo sapiens_hsa001000.86155633
78Regulation of autophagy_Homo sapiens_hsa041400.84988178
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84908094
80Nitrogen metabolism_Homo sapiens_hsa009100.84476763
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84269216
82Fanconi anemia pathway_Homo sapiens_hsa034600.83443659
83Ether lipid metabolism_Homo sapiens_hsa005650.83191211
84Folate biosynthesis_Homo sapiens_hsa007900.82945402
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.81045138
86Retinol metabolism_Homo sapiens_hsa008300.78971700
87Serotonergic synapse_Homo sapiens_hsa047260.77441704
88Sulfur metabolism_Homo sapiens_hsa009200.76368551
89Amphetamine addiction_Homo sapiens_hsa050310.76203129
90GABAergic synapse_Homo sapiens_hsa047270.73884070
91Circadian entrainment_Homo sapiens_hsa047130.73269716
92Renin secretion_Homo sapiens_hsa049240.73054779
93Purine metabolism_Homo sapiens_hsa002300.72202760
94Oxidative phosphorylation_Homo sapiens_hsa001900.71900506
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71473633
96Arachidonic acid metabolism_Homo sapiens_hsa005900.70045773
97Metabolic pathways_Homo sapiens_hsa011000.68589874
98Glutamatergic synapse_Homo sapiens_hsa047240.66554831
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.66181320
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65729076
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65494667
102Arginine biosynthesis_Homo sapiens_hsa002200.64135147
103Parkinsons disease_Homo sapiens_hsa050120.63359502
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62769788
105Non-homologous end-joining_Homo sapiens_hsa034500.61762615
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.61569236
107Mismatch repair_Homo sapiens_hsa034300.59558491
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58965344
109Primary immunodeficiency_Homo sapiens_hsa053400.57580621
110Collecting duct acid secretion_Homo sapiens_hsa049660.57074171
111Insulin secretion_Homo sapiens_hsa049110.56762016
112Cocaine addiction_Homo sapiens_hsa050300.56704196
113Synaptic vesicle cycle_Homo sapiens_hsa047210.53905956
114Ovarian steroidogenesis_Homo sapiens_hsa049130.53417589
115Alcoholism_Homo sapiens_hsa050340.51221598
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50094913
117Systemic lupus erythematosus_Homo sapiens_hsa053220.49750274
118Fatty acid elongation_Homo sapiens_hsa000620.49306299
119Alzheimers disease_Homo sapiens_hsa050100.49255791
120beta-Alanine metabolism_Homo sapiens_hsa004100.48770541
121Thyroid hormone synthesis_Homo sapiens_hsa049180.46745397
122Complement and coagulation cascades_Homo sapiens_hsa046100.46623470
123Vitamin digestion and absorption_Homo sapiens_hsa049770.46252692
124Starch and sucrose metabolism_Homo sapiens_hsa005000.44996532
125Spliceosome_Homo sapiens_hsa030400.44040725
126Protein digestion and absorption_Homo sapiens_hsa049740.43793814
127Renin-angiotensin system_Homo sapiens_hsa046140.43499657
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40080091
129Basal cell carcinoma_Homo sapiens_hsa052170.39825297
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39627429
131Antigen processing and presentation_Homo sapiens_hsa046120.38834784
132Asthma_Homo sapiens_hsa053100.38788455
133Dopaminergic synapse_Homo sapiens_hsa047280.36897327
134mRNA surveillance pathway_Homo sapiens_hsa030150.35995100
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35993553
136Gastric acid secretion_Homo sapiens_hsa049710.35756185
137Phenylalanine metabolism_Homo sapiens_hsa003600.35109934
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35094367
139Pancreatic secretion_Homo sapiens_hsa049720.34456846
140Histidine metabolism_Homo sapiens_hsa003400.33988824
141Arginine and proline metabolism_Homo sapiens_hsa003300.33671384
142Calcium signaling pathway_Homo sapiens_hsa040200.32144088
143Inositol phosphate metabolism_Homo sapiens_hsa005620.32120000
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.30326417
145Hedgehog signaling pathway_Homo sapiens_hsa043400.28493331
146AMPK signaling pathway_Homo sapiens_hsa041520.28204407
147Estrogen signaling pathway_Homo sapiens_hsa049150.26885995
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26472323
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25747264
150Taste transduction_Homo sapiens_hsa047420.24683500
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.19884259
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18414125
153Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18210735

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