SUOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.24643781
2L-phenylalanine catabolic process (GO:0006559)7.24643781
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.95904311
4L-phenylalanine metabolic process (GO:0006558)6.95904311
5aromatic amino acid family catabolic process (GO:0009074)6.46983709
6indole-containing compound catabolic process (GO:0042436)5.80569388
7indolalkylamine catabolic process (GO:0046218)5.80569388
8tryptophan catabolic process (GO:0006569)5.80569388
9kynurenine metabolic process (GO:0070189)5.76084513
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75902697
11cysteine metabolic process (GO:0006534)5.64593968
12bile acid biosynthetic process (GO:0006699)5.57423967
13tryptophan metabolic process (GO:0006568)5.53664706
14glyoxylate metabolic process (GO:0046487)5.49998103
15alpha-linolenic acid metabolic process (GO:0036109)5.48802194
16* sulfur amino acid catabolic process (GO:0000098)5.36179364
17urea metabolic process (GO:0019627)5.25216181
18urea cycle (GO:0000050)5.25216181
19high-density lipoprotein particle remodeling (GO:0034375)5.16155542
20negative regulation of fibrinolysis (GO:0051918)5.05169207
21serine family amino acid catabolic process (GO:0009071)5.04935779
22peptidyl-glutamic acid carboxylation (GO:0017187)5.02032452
23protein carboxylation (GO:0018214)5.02032452
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00739200
25complement activation, alternative pathway (GO:0006957)4.95028781
26bile acid metabolic process (GO:0008206)4.86922812
27regulation of protein activation cascade (GO:2000257)4.86201386
28nitrogen cycle metabolic process (GO:0071941)4.85234191
29lysine metabolic process (GO:0006553)4.84914319
30lysine catabolic process (GO:0006554)4.84914319
31regulation of fibrinolysis (GO:0051917)4.80651422
32homocysteine metabolic process (GO:0050667)4.78619912
33aromatic amino acid family metabolic process (GO:0009072)4.77071670
34reverse cholesterol transport (GO:0043691)4.57283409
35amino-acid betaine metabolic process (GO:0006577)4.56881525
36regulation of complement activation (GO:0030449)4.56606906
37tyrosine metabolic process (GO:0006570)4.55627031
38regulation of triglyceride catabolic process (GO:0010896)4.52935886
39alpha-amino acid catabolic process (GO:1901606)4.50223528
40protein-lipid complex remodeling (GO:0034368)4.41421415
41macromolecular complex remodeling (GO:0034367)4.41421415
42plasma lipoprotein particle remodeling (GO:0034369)4.41421415
43bile acid and bile salt transport (GO:0015721)4.39977428
44regulation of cholesterol esterification (GO:0010872)4.38559084
45negative regulation of sterol transport (GO:0032372)4.35361978
46negative regulation of cholesterol transport (GO:0032375)4.35361978
47cellular ketone body metabolic process (GO:0046950)4.34978771
48triglyceride homeostasis (GO:0070328)4.28596875
49acylglycerol homeostasis (GO:0055090)4.28596875
50indolalkylamine metabolic process (GO:0006586)4.22747470
51cellular modified amino acid catabolic process (GO:0042219)4.22212062
52* cellular amino acid catabolic process (GO:0009063)4.19889402
53coenzyme catabolic process (GO:0009109)4.15655292
54phospholipid efflux (GO:0033700)4.14186879
55glutamate metabolic process (GO:0006536)4.13204086
56ethanol oxidation (GO:0006069)4.12893496
57serine family amino acid metabolic process (GO:0009069)4.11306181
58glycine metabolic process (GO:0006544)4.10662269
59plasma lipoprotein particle clearance (GO:0034381)4.04095095
60cellular glucuronidation (GO:0052695)3.97768399
61benzene-containing compound metabolic process (GO:0042537)3.94408204
62cellular biogenic amine catabolic process (GO:0042402)3.93628915
63amine catabolic process (GO:0009310)3.93628915
64serine family amino acid biosynthetic process (GO:0009070)3.90418826
65short-chain fatty acid metabolic process (GO:0046459)3.90042141
66cholesterol efflux (GO:0033344)3.84988181
67exogenous drug catabolic process (GO:0042738)3.84350456
68imidazole-containing compound metabolic process (GO:0052803)3.83665518
69dicarboxylic acid biosynthetic process (GO:0043650)3.83644510
70regulation of cholesterol homeostasis (GO:2000188)3.76995992
71drug catabolic process (GO:0042737)3.74576966
72ketone body metabolic process (GO:1902224)3.74241463
73* organic acid catabolic process (GO:0016054)3.74229411
74* carboxylic acid catabolic process (GO:0046395)3.74229411
752-oxoglutarate metabolic process (GO:0006103)3.73825679
76arginine metabolic process (GO:0006525)3.68815728
77plasma lipoprotein particle assembly (GO:0034377)3.67509224
78low-density lipoprotein particle remodeling (GO:0034374)3.67409996
79acetyl-CoA metabolic process (GO:0006084)3.66779173
80aldehyde catabolic process (GO:0046185)3.66341021
81valine metabolic process (GO:0006573)3.65249639
82drug transmembrane transport (GO:0006855)3.65027902
83phospholipid homeostasis (GO:0055091)3.64316432
84regulation of bile acid biosynthetic process (GO:0070857)3.63841626
85fatty acid beta-oxidation (GO:0006635)3.63674298
86fibrinolysis (GO:0042730)3.62953704
87fatty acid oxidation (GO:0019395)3.62476863
88branched-chain amino acid catabolic process (GO:0009083)3.58105332
89aspartate family amino acid catabolic process (GO:0009068)3.57412338
90monocarboxylic acid catabolic process (GO:0072329)3.57099927
91lipid oxidation (GO:0034440)3.55661318
92uronic acid metabolic process (GO:0006063)3.55031689
93glucuronate metabolic process (GO:0019585)3.55031689
94positive regulation of lipid catabolic process (GO:0050996)3.54008248
95behavioral response to nicotine (GO:0035095)3.51776233
96cholesterol homeostasis (GO:0042632)3.51310007
97positive regulation of triglyceride lipase activity (GO:0061365)3.50996598
98positive regulation of lipoprotein lipase activity (GO:0051006)3.50996598
99fatty acid catabolic process (GO:0009062)3.48163713
100complement activation, classical pathway (GO:0006958)3.47354514
101sterol homeostasis (GO:0055092)3.46506193
102positive regulation of fatty acid beta-oxidation (GO:0032000)3.46302870
103negative regulation of lipase activity (GO:0060192)3.46296760
104dopamine transport (GO:0015872)3.43966167
105regulation of cilium movement (GO:0003352)3.37762175
106oxidative demethylation (GO:0070989)3.34976133
107piRNA metabolic process (GO:0034587)3.34784940
108S-adenosylmethionine metabolic process (GO:0046500)3.31062746
109water-soluble vitamin biosynthetic process (GO:0042364)3.30551536
110ubiquinone biosynthetic process (GO:0006744)3.19381457
111ubiquinone metabolic process (GO:0006743)3.17950928
112mannosylation (GO:0097502)3.14746469
113amino acid salvage (GO:0043102)3.09972468
114L-methionine salvage (GO:0071267)3.09972468
115L-methionine biosynthetic process (GO:0071265)3.09972468
116branched-chain amino acid metabolic process (GO:0009081)3.09873290
117preassembly of GPI anchor in ER membrane (GO:0016254)3.08347171
118L-fucose catabolic process (GO:0042355)3.08266991
119fucose catabolic process (GO:0019317)3.08266991
120L-fucose metabolic process (GO:0042354)3.08266991
121DNA methylation involved in gamete generation (GO:0043046)3.03582880
122quinone biosynthetic process (GO:1901663)2.91585956
123response to misfolded protein (GO:0051788)2.91292949
124methionine biosynthetic process (GO:0009086)2.82392336
125axoneme assembly (GO:0035082)2.80293229
126epithelial cilium movement (GO:0003351)2.78481953
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77518144
128epoxygenase P450 pathway (GO:0019373)2.72002077
129alkaloid metabolic process (GO:0009820)2.71453577
130peroxisome fission (GO:0016559)2.70037133
131nucleoside transmembrane transport (GO:1901642)2.69067832
132regulation of hexokinase activity (GO:1903299)2.66663689
133regulation of glucokinase activity (GO:0033131)2.66663689
134DNA integration (GO:0015074)2.66247069
135GPI anchor metabolic process (GO:0006505)2.65925178
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.62881970
137NADH dehydrogenase complex assembly (GO:0010257)2.62881970
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62881970
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61002043
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58485093
141GPI anchor biosynthetic process (GO:0006506)2.57855000
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54693851
143regulation of microtubule-based movement (GO:0060632)2.53852570
144nonmotile primary cilium assembly (GO:0035058)2.53515890
145phenylpropanoid metabolic process (GO:0009698)2.52989415
146protein complex biogenesis (GO:0070271)2.52901520
147flavonoid metabolic process (GO:0009812)2.50835332
148methionine metabolic process (GO:0006555)2.47707279
149biotin metabolic process (GO:0006768)2.46791007
150base-excision repair, AP site formation (GO:0006285)2.45284834
151arginine catabolic process (GO:0006527)2.44257239
152respiratory chain complex IV assembly (GO:0008535)2.43811331
153mitochondrial respiratory chain complex assembly (GO:0033108)2.39541540
154C4-dicarboxylate transport (GO:0015740)2.39490570
155xenobiotic catabolic process (GO:0042178)2.37964207
156dicarboxylic acid catabolic process (GO:0043649)2.37566195
157fatty acid transmembrane transport (GO:1902001)2.36299197
158macroautophagy (GO:0016236)2.35885241
159drug metabolic process (GO:0017144)2.35869049
160glutathione derivative biosynthetic process (GO:1901687)2.35330337
161glutathione derivative metabolic process (GO:1901685)2.35330337
162male meiosis (GO:0007140)2.33945351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.92176839
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88326392
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.23198060
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.20382482
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02060190
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92561250
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61981318
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86097187
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52571777
10ZNF274_21170338_ChIP-Seq_K562_Hela3.38002848
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36903772
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13166822
13VDR_22108803_ChIP-Seq_LS180_Human3.10244640
14IGF1R_20145208_ChIP-Seq_DFB_Human2.57242655
15GBX2_23144817_ChIP-Seq_PC3_Human2.35452842
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29385442
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26640356
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19675719
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04339983
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03885351
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02137236
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1884602
23GATA1_22025678_ChIP-Seq_K562_Human1.98522405
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.97821756
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.90464256
26CLOCK_20551151_ChIP-Seq_293T_Human1.90006310
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86666800
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79381300
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77993248
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76333698
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76166134
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.70092397
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70058071
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61420001
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61129948
36TP53_22573176_ChIP-Seq_HFKS_Human1.59752015
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58435934
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.58182363
39ER_23166858_ChIP-Seq_MCF-7_Human1.57217844
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56113281
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49643384
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47091097
43* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44817598
44EZH2_22144423_ChIP-Seq_EOC_Human1.43668018
45P300_19829295_ChIP-Seq_ESCs_Human1.43585895
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.43018337
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41638247
48EWS_26573619_Chip-Seq_HEK293_Human1.41620374
49NCOR_22424771_ChIP-Seq_293T_Human1.41239510
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40900589
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.40857039
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39215394
53MYC_18940864_ChIP-ChIP_HL60_Human1.36333366
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35963584
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.35963584
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35254993
57HOXB7_26014856_ChIP-Seq_BT474_Human1.33097018
58TAF15_26573619_Chip-Seq_HEK293_Human1.32182504
59IRF1_19129219_ChIP-ChIP_H3396_Human1.31285766
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29121806
61FUS_26573619_Chip-Seq_HEK293_Human1.28839742
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27191200
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.26620392
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25338044
65OCT4_20526341_ChIP-Seq_ESCs_Human1.24225075
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23547405
67HTT_18923047_ChIP-ChIP_STHdh_Human1.23068546
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22845182
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22807570
70* MYC_19829295_ChIP-Seq_ESCs_Human1.22004798
71STAT3_23295773_ChIP-Seq_U87_Human1.20935147
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20413662
73SOX2_19829295_ChIP-Seq_ESCs_Human1.20403852
74NANOG_19829295_ChIP-Seq_ESCs_Human1.20403852
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17013355
76ERA_21632823_ChIP-Seq_H3396_Human1.16995427
77NANOG_20526341_ChIP-Seq_ESCs_Human1.16774886
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16408609
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.14408644
80GATA4_25053715_ChIP-Seq_YYC3_Human1.13524422
81SMAD4_21799915_ChIP-Seq_A2780_Human1.12572736
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12468482
83AR_25329375_ChIP-Seq_VCAP_Human1.11842272
84VDR_23849224_ChIP-Seq_CD4+_Human1.11580019
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10790618
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09721152
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08966194
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.08771791
89ZNF263_19887448_ChIP-Seq_K562_Human1.06883745
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06256304
91TAF2_19829295_ChIP-Seq_ESCs_Human1.05940452
92TCF4_23295773_ChIP-Seq_U87_Human1.05515860
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05265328
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05080732
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03851788
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03110955
97RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02654050
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01107978
99CBP_20019798_ChIP-Seq_JUKART_Human1.01107978
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99978095
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99815291
102TCF4_22108803_ChIP-Seq_LS180_Human0.97896213
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97537673
104PHF8_20622853_ChIP-Seq_HELA_Human0.97397292
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96645010
106RAC3_21632823_ChIP-Seq_H3396_Human0.95893878
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94847951
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94839962
109REST_21632747_ChIP-Seq_MESCs_Mouse0.94665212
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94614257
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.94561569
112FOXH1_21741376_ChIP-Seq_EPCs_Human0.94147073
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94065710
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93020994
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91233910
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88495916
117* REST_18959480_ChIP-ChIP_MESCs_Mouse0.88317105
118FOXH1_21741376_ChIP-Seq_ESCs_Human0.87112981
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.87076363
120RNF2_27304074_Chip-Seq_NSC_Mouse0.86979379
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86252846
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85474743
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.83660966
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81077161
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79725517
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78751879
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78224919
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77141229
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76091442
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74222044
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74107392
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73230920
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73230920
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.72547813
135* GATA6_25053715_ChIP-Seq_YYC3_Human0.72444339
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.72253578
137LXR_22292898_ChIP-Seq_THP-1_Human0.71821693
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71542425
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.70292467
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68327481
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67491983
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67185556
143SOX2_20726797_ChIP-Seq_SW620_Human0.66518397
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.66247872
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.66134507
146KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64929457
147RARB_24833708_ChIP-Seq_LIVER_Mouse0.62908963
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62353556
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60866119
150GATA1_19941826_ChIP-Seq_K562_Human0.60599960
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60530238
152GATA2_19941826_ChIP-Seq_K562_Human0.60261469
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59857450
154CEBPB_22108803_ChIP-Seq_LS180_Human0.59186191
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58651724
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.57430436
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57189881
158RACK7_27058665_Chip-Seq_MCF-7_Human0.56322049
159AR_20517297_ChIP-Seq_VCAP_Human0.55601775
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55553042
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.53803100
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53421721
163GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52688122
164* TBX20_22080862_ChIP-Seq_HEART_Mouse0.52583215
165* TBX20_22328084_ChIP-Seq_HEART_Mouse0.52583215
166* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51917572
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.51124477
168STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50670349
169CBP_21632823_ChIP-Seq_H3396_Human0.49701163
170EGR1_19032775_ChIP-ChIP_M12_Human0.49597907
171MYC_19915707_ChIP-ChIP_AK7_Human0.49543480
172PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49108178
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48625276
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46287599
175ESET_19884257_ChIP-Seq_ESCs_Mouse0.46225047
176P53_21459846_ChIP-Seq_SAOS-2_Human0.45266955
177CDX2_22108803_ChIP-Seq_LS180_Human0.44661946
178ERG_20517297_ChIP-Seq_VCAP_Human0.44372681
179TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.43010566
180BCAT_22108803_ChIP-Seq_LS180_Human0.42986468
181STAT1_17558387_ChIP-Seq_HELA_Human0.42904550
182FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42776032
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.42743886
184GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.42524497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.92938686
2MP0005360_urolithiasis7.33497085
3MP0005085_abnormal_gallbladder_physiolo6.04354600
4MP0005365_abnormal_bile_salt5.96332413
5MP0008875_abnormal_xenobiotic_pharmacok4.76734801
6MP0003806_abnormal_nucleotide_metabolis4.08884246
7MP0003252_abnormal_bile_duct3.90207784
8MP0010329_abnormal_lipoprotein_level3.40802263
9MP0000372_irregular_coat_pigmentation3.21095173
10MP0009840_abnormal_foam_cell3.06937679
11MP0003136_yellow_coat_color3.00753019
12MP0003195_calcinosis2.95925932
13MP0005332_abnormal_amino_acid2.89372289
14MP0005083_abnormal_biliary_tract2.74926035
15MP0001666_abnormal_nutrient_absorption2.73725493
16MP0003646_muscle_fatigue2.52002586
17MP0003191_abnormal_cellular_cholesterol2.21525677
18MP0008877_abnormal_DNA_methylation2.17772594
19MP0004019_abnormal_vitamin_homeostasis2.17772505
20MP0000609_abnormal_liver_physiology2.13334665
21MP0002138_abnormal_hepatobiliary_system2.11537061
22MP0005551_abnormal_eye_electrophysiolog2.09538431
23MP0002638_abnormal_pupillary_reflex2.08150664
24MP0002118_abnormal_lipid_homeostasis2.07876372
25MP0004147_increased_porphyrin_level2.07397509
26MP0004145_abnormal_muscle_electrophysio2.03365305
27MP0006276_abnormal_autonomic_nervous1.96221208
28MP0003868_abnormal_feces_composition1.91918685
29MP0005645_abnormal_hypothalamus_physiol1.90018884
30MP0005319_abnormal_enzyme/_coenzyme1.87688957
31MP0002102_abnormal_ear_morphology1.78822430
32MP0005646_abnormal_pituitary_gland1.71892904
33MP0001529_abnormal_vocalization1.71279545
34MP0005253_abnormal_eye_physiology1.70675176
35MP0006072_abnormal_retinal_apoptosis1.69880015
36MP0001984_abnormal_olfaction1.69546410
37MP0002653_abnormal_ependyma_morphology1.66241531
38MP0005171_absent_coat_pigmentation1.61637225
39MP0009643_abnormal_urine_homeostasis1.59880466
40MP0005584_abnormal_enzyme/coenzyme_acti1.59785002
41MP0008872_abnormal_physiological_respon1.59596547
42MP0001968_abnormal_touch/_nociception1.57404047
43MP0001764_abnormal_homeostasis1.56633808
44MP0001986_abnormal_taste_sensitivity1.54249388
45MP0002938_white_spotting1.42939765
46MP0003879_abnormal_hair_cell1.42770262
47MP0008995_early_reproductive_senescence1.37825033
48MP0003705_abnormal_hypodermis_morpholog1.37383589
49MP0005075_abnormal_melanosome_morpholog1.37154131
50MP0004133_heterotaxia1.34594226
51MP0005377_hearing/vestibular/ear_phenot1.33960651
52MP0003878_abnormal_ear_physiology1.33960651
53MP0003186_abnormal_redox_activity1.30996788
54MP0003718_maternal_effect1.28818848
55MP0005451_abnormal_body_composition1.28075770
56MP0003656_abnormal_erythrocyte_physiolo1.22767190
57MP0005636_abnormal_mineral_homeostasis1.22462466
58MP0008789_abnormal_olfactory_epithelium1.19338654
59MP0001485_abnormal_pinna_reflex1.18307661
60MP0009697_abnormal_copulation1.16927302
61MP0002736_abnormal_nociception_after1.15986591
62MP0000598_abnormal_liver_morphology1.14932827
63MP0009046_muscle_twitch1.10748800
64MP0002160_abnormal_reproductive_system1.08998496
65MP0000631_abnormal_neuroendocrine_gland1.06709923
66MP0001905_abnormal_dopamine_level1.05347632
67MP0005647_abnormal_sex_gland1.04906233
68MP0002909_abnormal_adrenal_gland1.04723736
69MP0009745_abnormal_behavioral_response1.02843234
70MP0001756_abnormal_urination1.02702068
71MP0010386_abnormal_urinary_bladder1.02350078
72MP0002272_abnormal_nervous_system1.01678635
73MP0000604_amyloidosis1.01362289
74MP0009764_decreased_sensitivity_to1.00965145
75MP0002557_abnormal_social/conspecific_i0.99863138
76MP0008058_abnormal_DNA_repair0.99757831
77MP0003787_abnormal_imprinting0.99628844
78MP0001501_abnormal_sleep_pattern0.99126949
79MP0008775_abnormal_heart_ventricle0.99119616
80MP0001502_abnormal_circadian_rhythm0.98680925
81MP0003011_delayed_dark_adaptation0.97925898
82MP0005389_reproductive_system_phenotype0.97877466
83MP0002254_reproductive_system_inflammat0.97584055
84MP0002078_abnormal_glucose_homeostasis0.97069691
85MP0005220_abnormal_exocrine_pancreas0.96771232
86MP0005670_abnormal_white_adipose0.96043130
87MP0005410_abnormal_fertilization0.94852569
88MP0004885_abnormal_endolymph0.93910896
89MP0003698_abnormal_male_reproductive0.93664157
90MP0006292_abnormal_olfactory_placode0.93268163
91MP0002876_abnormal_thyroid_physiology0.91336957
92MP0009642_abnormal_blood_homeostasis0.91302577
93MP0004924_abnormal_behavior0.91234783
94MP0005386_behavior/neurological_phenoty0.91234783
95MP0004142_abnormal_muscle_tone0.91027592
96MP0003122_maternal_imprinting0.90858478
97MP0004215_abnormal_myocardial_fiber0.90450110
98MP0000427_abnormal_hair_cycle0.90345656
99MP0006036_abnormal_mitochondrial_physio0.89827174
100MP0009763_increased_sensitivity_to0.89751575
101MP0003137_abnormal_impulse_conducting0.89424590
102MP0004130_abnormal_muscle_cell0.88743067
103MP0002837_dystrophic_cardiac_calcinosis0.88363695
104MP0001324_abnormal_eye_pigmentation0.88363622
105MP0003880_abnormal_central_pattern0.88363293
106MP0005174_abnormal_tail_pigmentation0.87899848
107MP0008469_abnormal_protein_level0.87831306
108MP0004043_abnormal_pH_regulation0.86456651
109MP0005408_hypopigmentation0.84759501
110MP0000015_abnormal_ear_pigmentation0.84699887
111MP0000516_abnormal_urinary_system0.84294746
112MP0005367_renal/urinary_system_phenotyp0.84294746
113MP0002572_abnormal_emotion/affect_behav0.80928274
114MP0001929_abnormal_gametogenesis0.80788005
115MP0002095_abnormal_skin_pigmentation0.80322567
116MP0005084_abnormal_gallbladder_morpholo0.79622804
117MP0002971_abnormal_brown_adipose0.77873670
118MP0005334_abnormal_fat_pad0.76406639
119MP0010368_abnormal_lymphatic_system0.75601731
120MP0003300_gastrointestinal_ulcer0.75071800
121MP0005535_abnormal_body_temperature0.73848552
122MP0001661_extended_life_span0.72851148
123MP0009765_abnormal_xenobiotic_induced0.72771339
124MP0005376_homeostasis/metabolism_phenot0.72357702
125MP0004264_abnormal_extraembryonic_tissu0.71347096
126MP0005058_abnormal_lysosome_morphology0.70660932
127MP0002136_abnormal_kidney_physiology0.66539881
128MP0003329_amyloid_beta_deposits0.65657369
129MP0001765_abnormal_ion_homeostasis0.63592077
130MP0005666_abnormal_adipose_tissue0.63000336
131MP0005266_abnormal_metabolism0.59120783
132MP0010234_abnormal_vibrissa_follicle0.58194483
133MP0002928_abnormal_bile_duct0.56856503
134MP0005448_abnormal_energy_balance0.56666362
135MP0009053_abnormal_anal_canal0.53087396
136MP0003953_abnormal_hormone_level0.52833214
137MP0003638_abnormal_response/metabolism_0.51313880
138MP0001944_abnormal_pancreas_morphology0.51143225
139MP0000639_abnormal_adrenal_gland0.50949792
140MP0003690_abnormal_glial_cell0.49877021
141MP0006035_abnormal_mitochondrial_morpho0.49427462
142MP0000230_abnormal_systemic_arterial0.48196081
143MP0005395_other_phenotype0.48155096
144MP0009384_cardiac_valve_regurgitation0.47332911
145MP0002168_other_aberrant_phenotype0.46649975
146MP0005464_abnormal_platelet_physiology0.46477274
147MP0000538_abnormal_urinary_bladder0.42087388
148MP0005166_decreased_susceptibility_to0.40132262
149MP0008873_increased_physiological_sensi0.39826974
150MP0005248_abnormal_Harderian_gland0.39774658
151MP0009115_abnormal_fat_cell0.37291854
152MP0009672_abnormal_birth_weight0.37168837
153MP0001881_abnormal_mammary_gland0.36859763
154MP0002970_abnormal_white_adipose0.35859474
155MP0003959_abnormal_lean_body0.35763378
156MP0002269_muscular_atrophy0.34692837
157MP0003075_altered_response_to0.34125597
158MP0003436_decreased_susceptibility_to0.33883796
159MP0004782_abnormal_surfactant_physiolog0.32998502
160MP0008874_decreased_physiological_sensi0.32867915
161MP0001845_abnormal_inflammatory_respons0.32790452
162MP0002135_abnormal_kidney_morphology0.32410034
163MP0000249_abnormal_blood_vessel0.32027665
164MP0002796_impaired_skin_barrier0.31689261
165MP0002693_abnormal_pancreas_physiology0.30707285
166MP0002166_altered_tumor_susceptibility0.29516193
167MP0003724_increased_susceptibility_to0.29439313

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01868568
2Intrahepatic cholestasis (HP:0001406)6.86887513
3Deep venous thrombosis (HP:0002625)6.74558860
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.21562948
5Xanthomatosis (HP:0000991)5.90017308
6Prolonged partial thromboplastin time (HP:0003645)5.84952056
7Hypobetalipoproteinemia (HP:0003563)5.74384937
8Hyperlipoproteinemia (HP:0010980)5.01957679
9Complement deficiency (HP:0004431)4.89030429
10Hyperammonemia (HP:0001987)4.59554081
11Ketosis (HP:0001946)4.52915741
12Hyperglycinemia (HP:0002154)4.46409844
13Hypolipoproteinemia (HP:0010981)4.41715237
14Hypoglycemic coma (HP:0001325)4.37356980
15Hyperglycinuria (HP:0003108)4.29082618
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.27023101
17Joint hemorrhage (HP:0005261)4.19718304
18Abnormality of the common coagulation pathway (HP:0010990)4.19592910
19Abnormality of glycine metabolism (HP:0010895)4.15720341
20Abnormality of serine family amino acid metabolism (HP:0010894)4.15720341
21Epidermoid cyst (HP:0200040)4.09679671
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00407771
23Fat malabsorption (HP:0002630)3.97202047
24Hypoalphalipoproteinemia (HP:0003233)3.94727352
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.93176992
26* Abnormality of sulfur amino acid metabolism (HP:0004339)3.92437284
27Abnormality of the intrinsic pathway (HP:0010989)3.87302577
28Abnormality of methionine metabolism (HP:0010901)3.77169382
29Ketoacidosis (HP:0001993)3.65983923
30Abnormality of fatty-acid metabolism (HP:0004359)3.64232845
31Conjugated hyperbilirubinemia (HP:0002908)3.61514075
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.50296125
33Abnormality of complement system (HP:0005339)3.47134728
34Abnormality of pyrimidine metabolism (HP:0004353)3.24972287
35Pancreatic cysts (HP:0001737)3.24012971
36Molar tooth sign on MRI (HP:0002419)3.21351620
37Abnormality of midbrain morphology (HP:0002418)3.21351620
38Hypercholesterolemia (HP:0003124)3.21132853
39Hyperbilirubinemia (HP:0002904)3.19813324
40Type II lissencephaly (HP:0007260)3.12165880
41True hermaphroditism (HP:0010459)3.07225263
42Abnormality of serum amino acid levels (HP:0003112)3.00584096
43Congenital stationary night blindness (HP:0007642)2.95594390
44Hepatic necrosis (HP:0002605)2.94131710
45Steatorrhea (HP:0002570)2.92730903
46Delayed CNS myelination (HP:0002188)2.91817272
47Medial flaring of the eyebrow (HP:0010747)2.91774345
48Hypoglycemic seizures (HP:0002173)2.89113346
49Gout (HP:0001997)2.88198126
50* Abnormality of nucleobase metabolism (HP:0010932)2.84736659
51Metabolic acidosis (HP:0001942)2.84498654
52Abnormality of the renal cortex (HP:0011035)2.83856423
53Hepatocellular carcinoma (HP:0001402)2.82547978
54Pancreatic fibrosis (HP:0100732)2.82182362
55Myocardial infarction (HP:0001658)2.81875023
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76781675
57Dicarboxylic aciduria (HP:0003215)2.76781675
58Skin nodule (HP:0200036)2.75315916
59Acute encephalopathy (HP:0006846)2.67709576
60Hepatocellular necrosis (HP:0001404)2.65128094
61Generalized aminoaciduria (HP:0002909)2.64520950
62* Abnormality of purine metabolism (HP:0004352)2.63660854
63Vascular calcification (HP:0004934)2.62032521
64Lethargy (HP:0001254)2.61906799
65Attenuation of retinal blood vessels (HP:0007843)2.59723616
66Mitochondrial inheritance (HP:0001427)2.59602200
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.56671750
68Absent/shortened dynein arms (HP:0200106)2.56671750
69Nephronophthisis (HP:0000090)2.56144981
70Spontaneous abortion (HP:0005268)2.55677369
71Malnutrition (HP:0004395)2.55591879
72Late onset (HP:0003584)2.52135854
73Hyperinsulinemic hypoglycemia (HP:0000825)2.51777368
74Increased CSF lactate (HP:0002490)2.51220119
75Gait imbalance (HP:0002141)2.48230284
76Congenital primary aphakia (HP:0007707)2.47538421
77Calf muscle hypertrophy (HP:0008981)2.46890530
78Sensorimotor neuropathy (HP:0007141)2.45649301
79Acute necrotizing encephalopathy (HP:0006965)2.44816667
80Muscle hypertrophy of the lower extremities (HP:0008968)2.43757270
81Abnormal gallbladder morphology (HP:0012437)2.41782387
82Chronic hepatic failure (HP:0100626)2.40940568
83Systemic lupus erythematosus (HP:0002725)2.39845824
84Methylmalonic acidemia (HP:0002912)2.39352479
85Spastic diplegia (HP:0001264)2.38476740
86Irritability (HP:0000737)2.37132308
87Cardiovascular calcification (HP:0011915)2.33715879
88Acanthocytosis (HP:0001927)2.33355709
89Hypochromic microcytic anemia (HP:0004840)2.32358868
90Abolished electroretinogram (ERG) (HP:0000550)2.32314625
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32167301
92Abnormality of alanine metabolism (HP:0010916)2.32167301
93Hyperalaninemia (HP:0003348)2.32167301
94Cholelithiasis (HP:0001081)2.31753371
95Abnormality of the renal medulla (HP:0100957)2.31530376
96Pancreatitis (HP:0001733)2.30959056
97Neonatal onset (HP:0003623)2.30211581
98Cerebral edema (HP:0002181)2.27504587
99Nephrogenic diabetes insipidus (HP:0009806)2.27270784
100Esophageal varix (HP:0002040)2.25638689
101Abnormal mitochondria in muscle tissue (HP:0008316)2.25627972
102Lipid accumulation in hepatocytes (HP:0006561)2.24707827
1033-Methylglutaconic aciduria (HP:0003535)2.24568268
104Tubulointerstitial nephritis (HP:0001970)2.23186742
105Mitral stenosis (HP:0001718)2.22449416
106Hypothermia (HP:0002045)2.22053769
107Hyperventilation (HP:0002883)2.18644496
108Proximal tubulopathy (HP:0000114)2.18460300
109Decreased circulating renin level (HP:0003351)2.17337817
110Cystic liver disease (HP:0006706)2.16765177
111Alkalosis (HP:0001948)2.16336930
112Vomiting (HP:0002013)2.16175940
113Decreased central vision (HP:0007663)2.15861606
114Cholecystitis (HP:0001082)2.15112197
115Abnormal gallbladder physiology (HP:0012438)2.15112197
116Hyperglycemia (HP:0003074)2.14899625
117Hydroxyprolinuria (HP:0003080)2.14345958
118Abnormality of proline metabolism (HP:0010907)2.14345958
119Methylmalonic aciduria (HP:0012120)2.12676978
120Brushfield spots (HP:0001088)2.11588814
121Progressive macrocephaly (HP:0004481)2.11058589
122Abnormal respiratory epithelium morphology (HP:0012253)2.09412025
123Abnormal respiratory motile cilium morphology (HP:0005938)2.09412025
124Retinal dysplasia (HP:0007973)2.05486150
125Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04953659
126Glomerulonephritis (HP:0000099)2.04864341
127Hemorrhage of the eye (HP:0011885)2.04569406
128Menorrhagia (HP:0000132)2.04490609
129Enlarged kidneys (HP:0000105)2.04262525
130Cerebellar dysplasia (HP:0007033)2.02803885
131Cerebral palsy (HP:0100021)2.01541284
132Symptomatic seizures (HP:0011145)2.01197216
133Increased serum lactate (HP:0002151)2.01098734
134Amyloidosis (HP:0011034)1.99537809
135Recurrent gram-negative bacterial infections (HP:0005420)1.98824296
136Abnormal biliary tract physiology (HP:0012439)1.98387575
137Bile duct proliferation (HP:0001408)1.98387575
138Increased hepatocellular lipid droplets (HP:0006565)1.96968952
139Renal Fanconi syndrome (HP:0001994)1.96596024
140Abnormality of the gallbladder (HP:0005264)1.95568593
141Left ventricular hypertrophy (HP:0001712)1.95494227
142Lactic acidosis (HP:0003128)1.95344770
143Congenital sensorineural hearing impairment (HP:0008527)1.94895227
144Myoglobinuria (HP:0002913)1.94589768
145Rickets (HP:0002748)1.94147555
146Opisthotonus (HP:0002179)1.93205325
147Abnormal cartilage morphology (HP:0002763)1.93136460
148Abnormal enzyme/coenzyme activity (HP:0012379)1.92960115
149Tachypnea (HP:0002789)1.92658368
150Glycosuria (HP:0003076)1.92145732
151Abnormality of urine glucose concentration (HP:0011016)1.92145732
152Increased purine levels (HP:0004368)1.91668908
153Hyperuricemia (HP:0002149)1.91668908
154Congenital hepatic fibrosis (HP:0002612)1.90837651
155Increased muscle lipid content (HP:0009058)1.90420690
156Gingival bleeding (HP:0000225)1.88378932
157Increased intramyocellular lipid droplets (HP:0012240)1.88182034
158Polyphagia (HP:0002591)1.88024219
159Genital tract atresia (HP:0001827)1.87981652
160Abnormal drinking behavior (HP:0030082)1.86947283
161Polydipsia (HP:0001959)1.86947283
162Renal cortical cysts (HP:0000803)1.86556066
163Abnormality of transition element cation homeostasis (HP:0011030)1.85786308
164Tubular atrophy (HP:0000092)1.85465321
165Male pseudohermaphroditism (HP:0000037)1.84791307
166Absent speech (HP:0001344)1.84450648
167Vaginal atresia (HP:0000148)1.83544201
168Thrombophlebitis (HP:0004418)1.82861612
169Abnormality of vitamin metabolism (HP:0100508)1.82797218
170Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82193559
171Abnormal protein N-linked glycosylation (HP:0012347)1.82193559
172Abnormal protein glycosylation (HP:0012346)1.82193559
173Abnormal glycosylation (HP:0012345)1.82193559
174Generalized hypopigmentation of hair (HP:0011358)1.81898653
175Severe muscular hypotonia (HP:0006829)1.81233919
176Hypoplasia of the fovea (HP:0007750)1.80305697
177Aplasia/Hypoplasia of the fovea (HP:0008060)1.80305697
178Mesangial abnormality (HP:0001966)1.79959463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.30702704
2MAP4K24.41429383
3ERN14.31526323
4SIK14.14521968
5TAOK33.82739468
6FGFR43.76421771
7INSRR3.09753274
8TRIM282.88461162
9TRIB32.80988043
10FRK2.47167974
11STK162.42423726
12ERBB42.30228362
13PIK3CG2.19795325
14PKN22.18921678
15BMPR1B2.12054682
16ZAK2.08523886
17MUSK2.06361973
18FLT32.02136084
19GRK12.01107769
20ADRBK21.96199855
21LATS11.92553905
22PTK61.90457110
23OBSCN1.84074163
24MST1R1.83398543
25AKT31.70950602
26VRK21.70464624
27PHKG11.67491105
28PHKG21.67491105
29CCNB11.59175848
30MAPK131.54804251
31NEK11.46702237
32CSNK1G31.43075669
33TYK21.40965401
34MAP2K41.36336981
35MAPK111.36189566
36NME11.34427126
37NEK91.30039068
38CASK1.29436720
39MAP3K31.29313761
40ACVR1B1.21463057
41CSNK1G21.17626457
42MAP3K41.16937786
43TLK11.14942994
44FGFR21.12826848
45EPHB11.11988307
46JAK21.10503591
47TNK21.10469525
48MAP3K71.09997780
49JAK11.08958586
50MYLK1.08877453
51MAP2K31.08408087
52PRKCI1.06830349
53STK38L1.05892078
54PRKAA21.02422639
55MET1.00147939
56NTRK30.98815870
57KDR0.96071833
58EPHA30.95536858
59OXSR10.94186677
60TNIK0.94135234
61IRAK30.93851976
62MST40.93802484
63CSNK1A1L0.91812989
64MAP3K20.91572227
65GRK60.89584464
66PTK20.87655092
67MAP2K70.87641571
68PINK10.87496849
69EPHA40.87257402
70ABL20.86503566
71TBK10.85865869
72PDK40.85627207
73PDK30.85627207
74PRKCE0.80718585
75ADRBK10.78024595
76MAPK150.76790442
77PRKAA10.74738127
78TESK20.74089386
79MAP3K100.73705261
80TEC0.73347837
81PLK20.73316758
82PDK20.73054736
83DYRK20.71820303
84DYRK1B0.71042310
85ERBB20.68983236
86RIPK10.68706009
87FGFR30.68591934
88WNK40.68344940
89MARK10.66905255
90MAPKAPK50.66728203
91STK390.66437516
92GSK3A0.66337301
93NLK0.65981031
94SGK30.65620193
95PRKCG0.64654300
96PDGFRA0.64616913
97VRK10.64145059
98CDK60.63143522
99DAPK20.63080166
100GRK50.61373861
101PIM20.59667700
102CAMK2G0.59632134
103CAMK1D0.59158416
104TTN0.58668822
105PRKACG0.58587836
106LRRK20.58514144
107PRKACA0.56785370
108MAPK40.55815038
109PRKCZ0.55435655
110CAMK2A0.55143975
111WNK30.55039909
112RET0.54480678
113CSNK1A10.52184867
114PDPK10.51788671
115JAK30.51539018
116PTK2B0.51439408
117MAPKAPK30.51005179
118MAPK120.50799279
119MAP2K20.49676027
120CAMK2D0.49086249
121MAP3K140.48851137
122MTOR0.47685266
123PIK3CA0.46511089
124EEF2K0.46487684
125RPS6KA50.46405920
126MAP2K10.45952655
127FER0.45418435
128EIF2AK10.45117658
129PAK30.44727893
130MAP2K60.44513902
131LIMK10.44356828
132IRAK10.43554218
133PRKD10.43351955
134CSK0.42899879
135EPHA20.41746602
136PRKCQ0.41561263
137ZAP700.41306182
138TGFBR20.40358992
139LMTK20.40236398
140CAMK10.40203869
141CAMKK20.39711979
142CSF1R0.39510436
143ERBB30.39247237
144MAP3K110.38623337
145PRKACB0.38117859
146CAMK1G0.37568067
147PRKCA0.37192431
148IGF1R0.36753756
149NUAK10.36639465
150CSNK1D0.36346787
151MAP3K10.35976378
152SGK20.35714126
153TIE10.35404941
154ITK0.35001506
155ATR0.34435048
156IKBKE0.33583425
157TXK0.32770968
158PRKG10.32454331
159PKN10.31388025
160PDK10.30505062
161EGFR0.30049506
162PRKCH0.29345268
163STK30.29316639
164CSNK1G10.27918870
165SGK2230.26759873

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25079080
2Nitrogen metabolism_Homo sapiens_hsa009103.53714792
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32623701
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26898151
5Arginine biosynthesis_Homo sapiens_hsa002202.94620901
6Tryptophan metabolism_Homo sapiens_hsa003802.75833186
7Fatty acid degradation_Homo sapiens_hsa000712.69715638
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66849773
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59836751
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57765982
11Complement and coagulation cascades_Homo sapiens_hsa046102.46677011
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46127273
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23733585
14Butanoate metabolism_Homo sapiens_hsa006502.18514843
15Propanoate metabolism_Homo sapiens_hsa006402.12542138
16Peroxisome_Homo sapiens_hsa041462.09388102
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08071970
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03752189
19PPAR signaling pathway_Homo sapiens_hsa033201.92942920
20Histidine metabolism_Homo sapiens_hsa003401.92744407
21Fatty acid metabolism_Homo sapiens_hsa012121.92157498
22Chemical carcinogenesis_Homo sapiens_hsa052041.81122285
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80656623
24beta-Alanine metabolism_Homo sapiens_hsa004101.75377107
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.71079511
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68881410
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64614545
28Selenocompound metabolism_Homo sapiens_hsa004501.63672045
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.62237807
30Oxidative phosphorylation_Homo sapiens_hsa001901.59726620
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57926224
32Caffeine metabolism_Homo sapiens_hsa002321.57093862
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55534717
34Phenylalanine metabolism_Homo sapiens_hsa003601.54306880
35Retinol metabolism_Homo sapiens_hsa008301.53399554
36Bile secretion_Homo sapiens_hsa049761.53166171
37Pyruvate metabolism_Homo sapiens_hsa006201.47942160
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.46431681
39Staphylococcus aureus infection_Homo sapiens_hsa051501.44841383
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43486480
41Phototransduction_Homo sapiens_hsa047441.42308723
42Parkinsons disease_Homo sapiens_hsa050121.41597823
43Tyrosine metabolism_Homo sapiens_hsa003501.39662109
44Starch and sucrose metabolism_Homo sapiens_hsa005001.32181966
45Fatty acid elongation_Homo sapiens_hsa000621.26308614
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.26131219
47Folate biosynthesis_Homo sapiens_hsa007901.25806841
48ABC transporters_Homo sapiens_hsa020101.24424297
49Fat digestion and absorption_Homo sapiens_hsa049751.24338675
50* Sulfur metabolism_Homo sapiens_hsa009201.23509190
51Carbon metabolism_Homo sapiens_hsa012001.21721473
52Biosynthesis of amino acids_Homo sapiens_hsa012301.18028499
53Ether lipid metabolism_Homo sapiens_hsa005651.05128154
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04246845
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02965667
56Arginine and proline metabolism_Homo sapiens_hsa003301.02065220
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.99870527
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99478615
59Steroid biosynthesis_Homo sapiens_hsa001000.96550443
60Sulfur relay system_Homo sapiens_hsa041220.89833119
61Vitamin digestion and absorption_Homo sapiens_hsa049770.88439753
62Lysine degradation_Homo sapiens_hsa003100.85108160
63RNA polymerase_Homo sapiens_hsa030200.83513425
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83082792
65Vitamin B6 metabolism_Homo sapiens_hsa007500.82975883
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82234554
67Homologous recombination_Homo sapiens_hsa034400.82106954
68Huntingtons disease_Homo sapiens_hsa050160.78633408
69Taste transduction_Homo sapiens_hsa047420.78393260
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77491358
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76210112
72Glycerolipid metabolism_Homo sapiens_hsa005610.75655680
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73897980
74Nicotine addiction_Homo sapiens_hsa050330.72113975
75Cardiac muscle contraction_Homo sapiens_hsa042600.71444843
76Basal transcription factors_Homo sapiens_hsa030220.70613360
77Glutathione metabolism_Homo sapiens_hsa004800.69649731
78Alzheimers disease_Homo sapiens_hsa050100.66977762
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65770718
80Circadian rhythm_Homo sapiens_hsa047100.64184345
81Fanconi anemia pathway_Homo sapiens_hsa034600.61792584
82One carbon pool by folate_Homo sapiens_hsa006700.59563490
83Pentose phosphate pathway_Homo sapiens_hsa000300.56516848
84Insulin secretion_Homo sapiens_hsa049110.56004662
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55840292
86Fatty acid biosynthesis_Homo sapiens_hsa000610.55232415
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54585064
88Collecting duct acid secretion_Homo sapiens_hsa049660.52965484
89Serotonergic synapse_Homo sapiens_hsa047260.52695012
90Proteasome_Homo sapiens_hsa030500.51401141
91Purine metabolism_Homo sapiens_hsa002300.50679313
92Sphingolipid metabolism_Homo sapiens_hsa006000.50648030
93GABAergic synapse_Homo sapiens_hsa047270.48387294
94Metabolic pathways_Homo sapiens_hsa011000.46381538
95Insulin resistance_Homo sapiens_hsa049310.38873582
96Fructose and mannose metabolism_Homo sapiens_hsa000510.36063988
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35059934
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.32903961
99Galactose metabolism_Homo sapiens_hsa000520.32553208
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32525783
101Prion diseases_Homo sapiens_hsa050200.30751517
102Linoleic acid metabolism_Homo sapiens_hsa005910.21838094
103Glucagon signaling pathway_Homo sapiens_hsa049220.18730610
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.17998713
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15984972
106AMPK signaling pathway_Homo sapiens_hsa041520.12879798
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11580606
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04639689
109Renin-angiotensin system_Homo sapiens_hsa046140.01506337
110Insulin signaling pathway_Homo sapiens_hsa049100.00710284
111Mineral absorption_Homo sapiens_hsa04978-0.1482700
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1482152
113Protein digestion and absorption_Homo sapiens_hsa04974-0.1477077
114Hepatitis C_Homo sapiens_hsa05160-0.1463231
115Other glycan degradation_Homo sapiens_hsa00511-0.1409173
116Protein export_Homo sapiens_hsa03060-0.1393409
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1386401
118Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1378647
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1271518
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1021104
121Lysosome_Homo sapiens_hsa04142-0.0855832
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0786199
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0739955
124Regulation of autophagy_Homo sapiens_hsa04140-0.0582259
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0278766
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0037973
127Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0006162

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