SUPT16H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.09925323
2DNA unwinding involved in DNA replication (GO:0006268)5.75775635
3nuclear pore organization (GO:0006999)5.48976418
4DNA strand elongation involved in DNA replication (GO:0006271)5.25103194
5mitotic sister chromatid cohesion (GO:0007064)5.22422899
6establishment of integrated proviral latency (GO:0075713)5.10506696
7DNA strand elongation (GO:0022616)5.04629826
8protein localization to kinetochore (GO:0034501)4.83927267
9mitotic sister chromatid segregation (GO:0000070)4.74464481
10mitotic chromosome condensation (GO:0007076)4.71466710
11sister chromatid segregation (GO:0000819)4.69090451
12telomere maintenance via semi-conservative replication (GO:0032201)4.66046807
13mitotic metaphase plate congression (GO:0007080)4.49901985
14protein localization to chromosome, centromeric region (GO:0071459)4.46662636
15pore complex assembly (GO:0046931)4.45911859
16DNA replication initiation (GO:0006270)4.41801878
17DNA replication checkpoint (GO:0000076)4.09511046
18telomere maintenance via recombination (GO:0000722)4.06505258
19chromatin remodeling at centromere (GO:0031055)4.05826392
20mitotic nuclear envelope disassembly (GO:0007077)4.04914735
21IMP biosynthetic process (GO:0006188)4.02232778
22mitotic recombination (GO:0006312)4.02047219
23CENP-A containing nucleosome assembly (GO:0034080)4.01414347
24DNA topological change (GO:0006265)4.01400298
25regulation of centriole replication (GO:0046599)3.93426568
26metaphase plate congression (GO:0051310)3.93144953
27ribosome assembly (GO:0042255)3.91440300
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89319852
29non-recombinational repair (GO:0000726)3.88960452
30double-strand break repair via nonhomologous end joining (GO:0006303)3.88960452
31nuclear envelope disassembly (GO:0051081)3.80176954
32membrane disassembly (GO:0030397)3.80176954
33DNA ligation (GO:0006266)3.74847124
34establishment of viral latency (GO:0019043)3.74394514
35DNA duplex unwinding (GO:0032508)3.73437652
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68399400
37heterochromatin organization (GO:0070828)3.67014163
38DNA replication-dependent nucleosome assembly (GO:0006335)3.66050814
39DNA replication-dependent nucleosome organization (GO:0034723)3.66050814
40DNA geometric change (GO:0032392)3.65753024
41positive regulation of chromosome segregation (GO:0051984)3.63848847
42DNA replication-independent nucleosome organization (GO:0034724)3.61694641
43DNA replication-independent nucleosome assembly (GO:0006336)3.61694641
44IMP metabolic process (GO:0046040)3.61459154
45purine nucleobase biosynthetic process (GO:0009113)3.58362826
46folic acid-containing compound biosynthetic process (GO:0009396)3.55017650
47regulation of chromosome segregation (GO:0051983)3.52223836
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.51982820
49spindle checkpoint (GO:0031577)3.51950383
50kinetochore organization (GO:0051383)3.49340080
51histone exchange (GO:0043486)3.48132874
52nucleobase biosynthetic process (GO:0046112)3.47984868
53regulation of DNA endoreduplication (GO:0032875)3.46799413
54regulation of sister chromatid cohesion (GO:0007063)3.46447952
55negative regulation of mRNA processing (GO:0050686)3.46369700
56negative regulation of chromosome segregation (GO:0051985)3.45546514
57mitotic spindle checkpoint (GO:0071174)3.44938182
58meiotic chromosome segregation (GO:0045132)3.41902720
59formation of translation preinitiation complex (GO:0001731)3.39491840
60ATP-dependent chromatin remodeling (GO:0043044)3.38405986
61establishment of chromosome localization (GO:0051303)3.37711157
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.36898961
63negative regulation of sister chromatid segregation (GO:0033046)3.36898961
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36898961
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36898961
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36898961
67telomere maintenance via telomere lengthening (GO:0010833)3.33585631
68protein complex localization (GO:0031503)3.33426290
69regulation of translational fidelity (GO:0006450)3.32135946
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31578463
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.31578463
72DNA conformation change (GO:0071103)3.30802404
73somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30559688
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.30559688
75negative regulation of mRNA metabolic process (GO:1903312)3.28094846
76pre-miRNA processing (GO:0031054)3.25368457
77regulation of sister chromatid segregation (GO:0033045)3.24622027
78regulation of mitotic sister chromatid separation (GO:0010965)3.24622027
79regulation of mitotic sister chromatid segregation (GO:0033047)3.24622027
80mitotic spindle assembly checkpoint (GO:0007094)3.21203928
81DNA synthesis involved in DNA repair (GO:0000731)3.20405574
82chromosome condensation (GO:0030261)3.19380140
83chromosome segregation (GO:0007059)3.17821293
84spindle assembly checkpoint (GO:0071173)3.16088355
85regulation of centrosome cycle (GO:0046605)3.15957947
86protein localization to chromosome (GO:0034502)3.11555413
87chromatin assembly or disassembly (GO:0006333)3.11420242
88sister chromatid cohesion (GO:0007062)3.10577441
89L-serine metabolic process (GO:0006563)3.10505758
90negative regulation of RNA splicing (GO:0033119)3.05526431
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04167913
92DNA strand renaturation (GO:0000733)3.02603986
93telomere maintenance (GO:0000723)3.01299785
94telomere organization (GO:0032200)2.99499564
95DNA double-strand break processing (GO:0000729)2.99129101
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.97990504
97regulation of centrosome duplication (GO:0010824)2.95676703
98base-excision repair (GO:0006284)2.95154965
99cellular protein complex localization (GO:0034629)2.95116293
100regulation of helicase activity (GO:0051095)2.95082487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.09328644
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.64326962
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.08811276
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71494850
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26411357
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.08746082
7AR_21909140_ChIP-Seq_LNCAP_Human3.06821376
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93835682
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86151759
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75193860
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71368220
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.70146789
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55804188
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54209597
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.42004959
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.41146861
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39905841
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36771837
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35387624
20MYCN_18555785_ChIP-Seq_MESCs_Mouse2.27397377
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26779587
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.19254165
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17332673
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17308611
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15963098
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10466179
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.04138740
28E2F7_22180533_ChIP-Seq_HELA_Human10.8111758
29* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97622739
30XRN2_22483619_ChIP-Seq_HELA_Human1.96237129
31DCP1A_22483619_ChIP-Seq_HELA_Human1.93144048
32ELK1_19687146_ChIP-ChIP_HELA_Human1.90742955
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89782889
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89256853
35TTF2_22483619_ChIP-Seq_HELA_Human1.87552921
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85581854
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79190251
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77281511
39FOXP3_21729870_ChIP-Seq_TREG_Human1.76357139
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71262671
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62774325
42* GABP_19822575_ChIP-Seq_HepG2_Human1.59155057
43VDR_23849224_ChIP-Seq_CD4+_Human1.53095938
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.51050264
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.47168854
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45757453
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45436559
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45131189
49KDM5A_27292631_Chip-Seq_BREAST_Human1.37784521
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35942559
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35404096
52* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35383635
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34271200
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32884666
55* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32125591
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.22037899
57MYC_18940864_ChIP-ChIP_HL60_Human1.18669916
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14811549
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.13934182
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13437059
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12427725
62SOX17_20123909_ChIP-Seq_XEN_Mouse1.12255504
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11540827
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10753762
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.06419511
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04868801
67CIITA_25753668_ChIP-Seq_RAJI_Human1.02339313
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01652277
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01552130
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00665480
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00293922
72YY1_21170310_ChIP-Seq_MESCs_Mouse0.99282496
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98689965
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98221782
75MYC_22102868_ChIP-Seq_BL_Human0.97490861
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96190156
77NANOG_21062744_ChIP-ChIP_HESCs_Human0.95712734
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95003889
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94766652
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.93229301
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92607383
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91121149
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90417262
84CHD1_26751641_Chip-Seq_LNCaP_Human0.90327318
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88919175
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86188340
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85407583
88* TFEB_21752829_ChIP-Seq_HELA_Human0.84980325
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84949464
90EWS_26573619_Chip-Seq_HEK293_Human0.81201113
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80143588
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79888205
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79000137
94TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78779546
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76518593
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76320366
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72122243
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70953991
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.67476803
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65940574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.30979382
2MP0008057_abnormal_DNA_replication4.65217765
3MP0003693_abnormal_embryo_hatching4.63153714
4MP0003111_abnormal_nucleus_morphology4.49762558
5MP0004957_abnormal_blastocyst_morpholog4.11523095
6MP0008058_abnormal_DNA_repair3.85039425
7MP0003077_abnormal_cell_cycle3.72515378
8MP0008932_abnormal_embryonic_tissue2.97816220
9MP0008007_abnormal_cellular_replicative2.60919018
10MP0001730_embryonic_growth_arrest2.37286625
11MP0010352_gastrointestinal_tract_polyps2.29927254
12MP0003941_abnormal_skin_development2.17090887
13MP0000350_abnormal_cell_proliferation2.12269315
14MP0008877_abnormal_DNA_methylation2.09870198
15MP0009672_abnormal_birth_weight2.00394812
16MP0009697_abnormal_copulation1.98742900
17MP0003890_abnormal_embryonic-extraembry1.93670685
18MP0001672_abnormal_embryogenesis/_devel1.89191672
19MP0005380_embryogenesis_phenotype1.89191672
20MP0001697_abnormal_embryo_size1.81365258
21MP0010307_abnormal_tumor_latency1.80895441
22MP0002084_abnormal_developmental_patter1.76622042
23MP0002085_abnormal_embryonic_tissue1.69808128
24MP0003718_maternal_effect1.68047869
25MP0003984_embryonic_growth_retardation1.67921714
26MP0002080_prenatal_lethality1.64692005
27MP0001293_anophthalmia1.64671426
28MP0002088_abnormal_embryonic_growth/wei1.62678233
29MP0003937_abnormal_limbs/digits/tail_de1.59853736
30MP0004197_abnormal_fetal_growth/weight/1.53453444
31MP0002697_abnormal_eye_size1.46444188
32MP0003786_premature_aging1.43895295
33MP0002396_abnormal_hematopoietic_system1.41037211
34MP0003567_abnormal_fetal_cardiomyocyte1.37179758
35MP0009703_decreased_birth_body1.35787078
36MP0000537_abnormal_urethra_morphology1.32274318
37MP0006292_abnormal_olfactory_placode1.31673428
38MP0000313_abnormal_cell_death1.29495090
39MP0002086_abnormal_extraembryonic_tissu1.28772957
40MP0003123_paternal_imprinting1.18970343
41MP0001286_abnormal_eye_development1.17419108
42MP0005076_abnormal_cell_differentiation1.16834992
43MP0002009_preneoplasia1.16112096
44MP0003315_abnormal_perineum_morphology1.15742184
45MP0002877_abnormal_melanocyte_morpholog1.11630422
46MP0006035_abnormal_mitochondrial_morpho1.09713078
47MP0010030_abnormal_orbit_morphology1.09479813
48MP0003121_genomic_imprinting1.08467331
49MP0003119_abnormal_digestive_system1.05541137
50MP0004233_abnormal_muscle_weight1.04321826
51MP0002233_abnormal_nose_morphology1.03189381
52MP0000428_abnormal_craniofacial_morphol1.03118703
53MP0002210_abnormal_sex_determination1.02546277
54MP0002111_abnormal_tail_morphology1.02003167
55MP0003861_abnormal_nervous_system0.99981777
56MP0002092_abnormal_eye_morphology0.97580886
57MP0000358_abnormal_cell_content/0.96629528
58MP0001346_abnormal_lacrimal_gland0.94470560
59MP0003705_abnormal_hypodermis_morpholog0.93729662
60MP0003943_abnormal_hepatobiliary_system0.91317098
61MP0001929_abnormal_gametogenesis0.89930829
62MP0002938_white_spotting0.89776108
63MP0001145_abnormal_male_reproductive0.88382696
64MP0003221_abnormal_cardiomyocyte_apopto0.85167731
65MP0003115_abnormal_respiratory_system0.83321148
66MP0004185_abnormal_adipocyte_glucose0.83137694
67MP0002019_abnormal_tumor_incidence0.82919089
68MP0005384_cellular_phenotype0.81188164
69MP0004808_abnormal_hematopoietic_stem0.80709115
70MP0001661_extended_life_span0.78993072
71MP0003755_abnormal_palate_morphology0.78502379
72MP0000566_synostosis0.78093791
73MP0000579_abnormal_nail_morphology0.77951010
74MP0005623_abnormal_meninges_morphology0.76681745
75MP0003935_abnormal_craniofacial_develop0.76634254
76MP0000653_abnormal_sex_gland0.76308894
77MP0000432_abnormal_head_morphology0.76023715
78MP0003385_abnormal_body_wall0.75371356
79MP0000490_abnormal_crypts_of0.75043062
80MP0001299_abnormal_eye_distance/0.75042522
81MP0005501_abnormal_skin_physiology0.74259759
82MP0005621_abnormal_cell_physiology0.72312631
83MP0002751_abnormal_autonomic_nervous0.70711653
84MP0001529_abnormal_vocalization0.69356111
85MP0002081_perinatal_lethality0.68738570
86MP0001915_intracranial_hemorrhage0.68334439
87MP0000762_abnormal_tongue_morphology0.67403881
88MP0002254_reproductive_system_inflammat0.66892694
89MP0001177_atelectasis0.66868577
90MP0009053_abnormal_anal_canal0.65396906
91MP0000049_abnormal_middle_ear0.63864425
92MP0005391_vision/eye_phenotype0.63597676
93MP0000647_abnormal_sebaceous_gland0.62501206
94MP0006072_abnormal_retinal_apoptosis0.62355661
95MP0001849_ear_inflammation0.61907772
96MP0002102_abnormal_ear_morphology0.60769551
97MP0001119_abnormal_female_reproductive0.60602063
98MP0002160_abnormal_reproductive_system0.60292220
99MP0003122_maternal_imprinting0.60240036
100MP0004264_abnormal_extraembryonic_tissu0.60070169

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.43589773
2Chromsome breakage (HP:0040012)5.12810527
3Increased nuchal translucency (HP:0010880)3.79214109
4Meckel diverticulum (HP:0002245)3.73480680
5Volvulus (HP:0002580)3.63743842
6Abnormality of chromosome stability (HP:0003220)3.57494119
7Nephroblastoma (Wilms tumor) (HP:0002667)3.55111808
8Abnormality of the ileum (HP:0001549)3.53417330
9Birth length less than 3rd percentile (HP:0003561)3.45989225
10Embryonal renal neoplasm (HP:0011794)3.36314483
11Abnormality of the preputium (HP:0100587)3.35980298
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.19416537
13Ependymoma (HP:0002888)3.17195269
14Cortical dysplasia (HP:0002539)3.09838675
15Abnormality of the labia minora (HP:0012880)3.04942803
16Abnormal lung lobation (HP:0002101)2.91152530
17Duodenal stenosis (HP:0100867)2.84513148
18Small intestinal stenosis (HP:0012848)2.84513148
19Multiple enchondromatosis (HP:0005701)2.79706952
20Colon cancer (HP:0003003)2.78580942
21Medulloblastoma (HP:0002885)2.74838557
22Proximal placement of thumb (HP:0009623)2.58869629
23Abnormality of the carotid arteries (HP:0005344)2.57804907
24Rhabdomyosarcoma (HP:0002859)2.54108533
25Abnormality of the duodenum (HP:0002246)2.50378218
26Deviation of the thumb (HP:0009603)2.48623625
27Myelodysplasia (HP:0002863)2.48609938
28High anterior hairline (HP:0009890)2.46362011
29Ectopic kidney (HP:0000086)2.41914609
30Absent radius (HP:0003974)2.41762244
31Aplasia/Hypoplasia of the sternum (HP:0006714)2.39339571
32Glioma (HP:0009733)2.38494256
33Spastic diplegia (HP:0001264)2.37256530
34Microvesicular hepatic steatosis (HP:0001414)2.33329330
35Abnormality of the astrocytes (HP:0100707)2.32483719
36Astrocytoma (HP:0009592)2.32483719
37Cafe-au-lait spot (HP:0000957)2.27815707
38Selective tooth agenesis (HP:0001592)2.26577852
39Sloping forehead (HP:0000340)2.24823846
40Aplasia involving forearm bones (HP:0009822)2.24143232
41Absent forearm bone (HP:0003953)2.24143232
42Overlapping toe (HP:0001845)2.23417826
43Facial cleft (HP:0002006)2.14920264
44Embryonal neoplasm (HP:0002898)2.13311933
45Choanal atresia (HP:0000453)2.09414071
46Progressive external ophthalmoplegia (HP:0000590)2.06573750
47Neoplasm of the colon (HP:0100273)2.04255954
48Horseshoe kidney (HP:0000085)2.03992407
49Atresia of the external auditory canal (HP:0000413)2.01851345
50Triphalangeal thumb (HP:0001199)2.00383526
51Malignant gastrointestinal tract tumors (HP:0006749)1.91640861
52Gastrointestinal carcinoma (HP:0002672)1.91640861
53Microglossia (HP:0000171)1.88405802
54Squamous cell carcinoma (HP:0002860)1.87751755
55Abnormality of chromosome segregation (HP:0002916)1.86729943
56Abnormality of glycolysis (HP:0004366)1.84210976
57Shoulder girdle muscle weakness (HP:0003547)1.82984718
58Deep philtrum (HP:0002002)1.81729809
59Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80875986
60Reticulocytopenia (HP:0001896)1.80303174
61Skull defect (HP:0001362)1.78538399
62Neuroblastoma (HP:0003006)1.78524870
63Primitive neuroectodermal tumor (HP:0030065)1.78524870
64Neuroblastic tumors (HP:0004376)1.78524870
65Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.78524870
66Postnatal microcephaly (HP:0005484)1.78102398
67Carpal bone hypoplasia (HP:0001498)1.78050657
68Patellar aplasia (HP:0006443)1.75559109
69Clubbing of toes (HP:0100760)1.74938756
70Hepatoblastoma (HP:0002884)1.74192315
71Arteriovenous malformation (HP:0100026)1.72070253
72Abnormal number of incisors (HP:0011064)1.71442951
73Abnormality of cochlea (HP:0000375)1.71193292
74Neoplasm of striated muscle (HP:0009728)1.68918328
75Missing ribs (HP:0000921)1.67503874
76Irregular epiphyses (HP:0010582)1.66619966
77Nervous tissue neoplasm (HP:0030060)1.65501753
78Neuroectodermal neoplasm (HP:0030061)1.65501753
79Neuroepithelial neoplasm (HP:0030063)1.65501753
80Neoplasm of the adrenal cortex (HP:0100641)1.63169948
81Pancreatic islet-cell hyperplasia (HP:0004510)1.62576091
82Obsessive-compulsive behavior (HP:0000722)1.61050964
83Urethral obstruction (HP:0000796)1.60698380
84Uterine neoplasm (HP:0010784)1.60675344
85Leiomyosarcoma (HP:0100243)1.58805226
86Uterine leiomyosarcoma (HP:0002891)1.58805226
87Overriding aorta (HP:0002623)1.57605793
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.57090750
89Bifid tongue (HP:0010297)1.57060524
90Capillary hemangiomas (HP:0005306)1.56492669
91Abnormality of methionine metabolism (HP:0010901)1.56449814
92Absent epiphyses (HP:0010577)1.55374040
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55374040
94Insomnia (HP:0100785)1.54770334
95Poikiloderma (HP:0001029)1.54687692
96Duplication of thumb phalanx (HP:0009942)1.54371397
97Aplasia/Hypoplasia of the patella (HP:0006498)1.53528075
98High pitched voice (HP:0001620)1.53206381
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52985375
100Premature ovarian failure (HP:0008209)1.52675311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.38466221
2BUB13.96280881
3SRPK13.71179698
4TSSK63.63725623
5TTK3.61152736
6NEK13.14839815
7EIF2AK12.90490759
8MKNK12.43075639
9PLK42.35435984
10WEE12.32021549
11PLK32.27691472
12MKNK22.24404037
13PBK2.23261476
14VRK22.14682168
15EIF2AK32.04106037
16PNCK2.03589291
17TAF12.00976385
18CDK121.98456020
19SMG11.74488204
20MAP3K101.73738803
21ATR1.68504262
22PLK11.67234762
23BRD41.61892041
24BRSK21.60435120
25CHEK21.53338025
26NEK21.42148784
27LATS11.41882875
28ZAK1.41039586
29TRIM281.39079907
30CDK71.32202514
31CHEK11.31558361
32SCYL21.28903809
33PASK1.27628571
34NUAK11.24893750
35ALK1.19040374
36* AURKB1.18541951
37EEF2K1.18035121
38BRSK11.15399255
39VRK11.14475327
40ATM1.13836194
41MST41.07772230
42EIF2AK21.02457432
43RPS6KB20.97621486
44CDK60.93828086
45CAMK1G0.93216573
46STK160.91799195
47CLK10.89271953
48RPS6KA40.89134007
49CDK40.87940379
50FGFR10.86848447
51BCR0.81756708
52CDK10.80914707
53STK30.79300460
54CDK20.77075093
55STK40.73120067
56CSNK1E0.71345855
57MAP3K80.71137100
58AURKA0.69941529
59LATS20.69049542
60PAK40.68430190
61ERBB40.67839621
62CDK80.64230655
63STK38L0.64106140
64MET0.63989386
65MELK0.62182899
66MST1R0.60563012
67TNIK0.59447486
68CDK30.59239372
69PRKDC0.58952910
70CDK90.55344463
71STK100.54783172
72CSNK1G10.53871633
73CSNK2A20.52547649
74NME10.52029675
75NME20.50411603
76DYRK30.47193912
77YES10.43694602
78MAP3K90.43269354
79CDK180.43033447
80WNK30.42348061
81CAMK1D0.41920757
82CSNK2A10.41371576
83PLK20.41032545
84CDK11A0.39802664
85PDGFRA0.39490118
86CDK150.39363355
87DAPK10.38200766
88MTOR0.37593193
89ICK0.36687549
90CCNB10.34540673
91MAPK140.33929939
92CDK140.32747374
93FGFR20.31750962
94CSNK1G30.30568628
95CSNK1A1L0.30308508
96PKN20.30155445
97MAP4K20.28998193
98GSK3B0.28950397
99BRAF0.27509440
100RPS6KB10.25737147

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04189883
2Mismatch repair_Homo sapiens_hsa034304.34367983
3Non-homologous end-joining_Homo sapiens_hsa034503.66169905
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22447064
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.20065723
6Base excision repair_Homo sapiens_hsa034103.08160173
7Cell cycle_Homo sapiens_hsa041103.02453725
8Spliceosome_Homo sapiens_hsa030402.98304123
9RNA transport_Homo sapiens_hsa030132.90522958
10Homologous recombination_Homo sapiens_hsa034402.72531850
11One carbon pool by folate_Homo sapiens_hsa006702.62157109
12Nucleotide excision repair_Homo sapiens_hsa034202.57744293
13Proteasome_Homo sapiens_hsa030502.53660404
14Fanconi anemia pathway_Homo sapiens_hsa034602.42557060
15mRNA surveillance pathway_Homo sapiens_hsa030152.11101682
16RNA polymerase_Homo sapiens_hsa030201.93994763
17RNA degradation_Homo sapiens_hsa030181.74020916
18Pyrimidine metabolism_Homo sapiens_hsa002401.67645187
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63502079
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.60497035
21Biosynthesis of amino acids_Homo sapiens_hsa012301.58192316
22Basal transcription factors_Homo sapiens_hsa030221.53770188
23Selenocompound metabolism_Homo sapiens_hsa004501.53188998
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37490665
25Vitamin B6 metabolism_Homo sapiens_hsa007501.28736997
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28418810
27Oocyte meiosis_Homo sapiens_hsa041141.21501874
28Pyruvate metabolism_Homo sapiens_hsa006201.17804716
29Carbon metabolism_Homo sapiens_hsa012001.15983533
30Protein export_Homo sapiens_hsa030601.15458840
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13577721
32Steroid biosynthesis_Homo sapiens_hsa001001.11353585
33Lysine degradation_Homo sapiens_hsa003101.07834969
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07771482
35p53 signaling pathway_Homo sapiens_hsa041151.06802488
36Purine metabolism_Homo sapiens_hsa002301.06293556
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05263296
38Propanoate metabolism_Homo sapiens_hsa006401.05041472
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97889552
40Thyroid cancer_Homo sapiens_hsa052160.93257707
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86512930
42Ribosome_Homo sapiens_hsa030100.85525458
43Adherens junction_Homo sapiens_hsa045200.85521831
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84401554
45Pentose phosphate pathway_Homo sapiens_hsa000300.81376518
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77653281
47MicroRNAs in cancer_Homo sapiens_hsa052060.76800667
48Hippo signaling pathway_Homo sapiens_hsa043900.73618171
49N-Glycan biosynthesis_Homo sapiens_hsa005100.69257779
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69217523
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.68536482
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67846178
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62964295
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62442859
55Wnt signaling pathway_Homo sapiens_hsa043100.62069756
56Fatty acid elongation_Homo sapiens_hsa000620.61159881
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61075200
58Basal cell carcinoma_Homo sapiens_hsa052170.59601933
59Colorectal cancer_Homo sapiens_hsa052100.58592276
60TGF-beta signaling pathway_Homo sapiens_hsa043500.55688935
61Epstein-Barr virus infection_Homo sapiens_hsa051690.54143300
62Viral carcinogenesis_Homo sapiens_hsa052030.52766924
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51866924
64Fatty acid metabolism_Homo sapiens_hsa012120.49997279
65Prostate cancer_Homo sapiens_hsa052150.49296834
66Folate biosynthesis_Homo sapiens_hsa007900.43061292
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42341471
68Hedgehog signaling pathway_Homo sapiens_hsa043400.41945421
69Small cell lung cancer_Homo sapiens_hsa052220.39868505
70Chronic myeloid leukemia_Homo sapiens_hsa052200.39030494
71Glutathione metabolism_Homo sapiens_hsa004800.37306265
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33908470
73Bladder cancer_Homo sapiens_hsa052190.33078169
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32904473
75Tight junction_Homo sapiens_hsa045300.31702191
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.31239858
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31088496
78HTLV-I infection_Homo sapiens_hsa051660.29278781
79Alcoholism_Homo sapiens_hsa050340.25651230
80Metabolic pathways_Homo sapiens_hsa011000.25218790
81Arginine and proline metabolism_Homo sapiens_hsa003300.23343232
82Proteoglycans in cancer_Homo sapiens_hsa052050.22116259
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21687918
84Endometrial cancer_Homo sapiens_hsa052130.21293168
85Pancreatic cancer_Homo sapiens_hsa052120.19556525
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18741340
87Herpes simplex infection_Homo sapiens_hsa051680.17936340
88Fructose and mannose metabolism_Homo sapiens_hsa000510.17600217
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16196831
90Melanoma_Homo sapiens_hsa052180.16086324
91Sulfur relay system_Homo sapiens_hsa041220.15324358
92Systemic lupus erythematosus_Homo sapiens_hsa053220.13904253
93Huntingtons disease_Homo sapiens_hsa050160.13198150
94Non-small cell lung cancer_Homo sapiens_hsa052230.12808311
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12620149
96Pathways in cancer_Homo sapiens_hsa052000.11957531
97Fatty acid biosynthesis_Homo sapiens_hsa000610.08696373
98Galactose metabolism_Homo sapiens_hsa000520.07618204
99Apoptosis_Homo sapiens_hsa042100.05529868
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04954545

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