SUPT16HP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.81770213
2regulation of mitotic spindle checkpoint (GO:1903504)4.81770213
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.80826222
4microtubule depolymerization (GO:0007019)4.66348162
5proteasome assembly (GO:0043248)4.53706076
6chromatin remodeling at centromere (GO:0031055)4.11717764
7CENP-A containing nucleosome assembly (GO:0034080)4.09957958
8DNA damage response, detection of DNA damage (GO:0042769)4.07316121
9protein neddylation (GO:0045116)4.00214013
10cullin deneddylation (GO:0010388)3.87897148
11DNA double-strand break processing (GO:0000729)3.87733161
12somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.87411169
13isotype switching (GO:0045190)3.87411169
14somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.87411169
15DNA catabolic process, exonucleolytic (GO:0000738)3.81245015
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78713552
17protein localization to kinetochore (GO:0034501)3.78366282
18RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.77465266
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74193188
20base-excision repair, AP site formation (GO:0006285)3.71169355
21histone exchange (GO:0043486)3.68566624
22rRNA modification (GO:0000154)3.65911756
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63859951
24protein deneddylation (GO:0000338)3.61432679
25DNA ligation (GO:0006266)3.61317813
26DNA replication checkpoint (GO:0000076)3.57717900
27establishment of integrated proviral latency (GO:0075713)3.56321985
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.51655970
29termination of RNA polymerase III transcription (GO:0006386)3.51655970
30IMP biosynthetic process (GO:0006188)3.50796630
31regulation of helicase activity (GO:0051095)3.49831840
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48319641
33chaperone-mediated protein transport (GO:0072321)3.46705930
34mitotic metaphase plate congression (GO:0007080)3.45532034
35ribosome assembly (GO:0042255)3.42667538
36rRNA methylation (GO:0031167)3.34342537
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33397914
38DNA replication-dependent nucleosome organization (GO:0034723)3.32815189
39DNA replication-dependent nucleosome assembly (GO:0006335)3.32815189
40mitotic sister chromatid segregation (GO:0000070)3.32798125
41negative regulation of ligase activity (GO:0051352)3.27665797
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27665797
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26900754
44respiratory chain complex IV assembly (GO:0008535)3.25965634
45DNA deamination (GO:0045006)3.22358817
46DNA strand elongation involved in DNA replication (GO:0006271)3.20939039
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.20872347
48mismatch repair (GO:0006298)3.18923444
49somatic recombination of immunoglobulin gene segments (GO:0016447)3.16999785
50regulation of cellular amino acid metabolic process (GO:0006521)3.14376727
51DNA strand elongation (GO:0022616)3.13483046
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13339689
53sister chromatid segregation (GO:0000819)3.11268019
54protein-cofactor linkage (GO:0018065)3.10910869
55neuron fate determination (GO:0048664)3.10616914
56metaphase plate congression (GO:0051310)3.09819941
57histone mRNA metabolic process (GO:0008334)3.08881148
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05778907
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05778907
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05778907
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05005205
62branched-chain amino acid catabolic process (GO:0009083)3.03140653
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00235363
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00235363
65attachment of spindle microtubules to kinetochore (GO:0008608)3.00090839
66somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99987964
67somatic hypermutation of immunoglobulin genes (GO:0016446)2.99987964
687-methylguanosine mRNA capping (GO:0006370)2.97700473
69signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97060910
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.97060910
71pseudouridine synthesis (GO:0001522)2.96672422
72regulation of centriole replication (GO:0046599)2.96117053
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.96116993
74DNA replication-independent nucleosome assembly (GO:0006336)2.94892693
75DNA replication-independent nucleosome organization (GO:0034724)2.94892693
76somatic diversification of immunoglobulins (GO:0016445)2.91156231
77IMP metabolic process (GO:0046040)2.90631448
78somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.89876716
79somatic cell DNA recombination (GO:0016444)2.89876716
807-methylguanosine RNA capping (GO:0009452)2.89843173
81RNA capping (GO:0036260)2.89843173
82protein complex biogenesis (GO:0070271)2.89182125
83protein localization to chromosome, centromeric region (GO:0071459)2.88164628
84intracellular protein transmembrane import (GO:0044743)2.84398711
85telomere maintenance via semi-conservative replication (GO:0032201)2.83654514
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.83504200
87NADH dehydrogenase complex assembly (GO:0010257)2.83504200
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83504200
89spindle checkpoint (GO:0031577)2.82973815
90establishment of viral latency (GO:0019043)2.81236696
91centriole replication (GO:0007099)2.81178713
92mitotic spindle checkpoint (GO:0071174)2.80623113
93mitochondrial respiratory chain complex assembly (GO:0033108)2.79707018
94replication fork processing (GO:0031297)2.77177379
95cytochrome complex assembly (GO:0017004)2.75916379
96spliceosomal snRNP assembly (GO:0000387)2.75866640
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73993142
98somatic diversification of immune receptors (GO:0002200)2.73472183
99negative regulation of DNA recombination (GO:0045910)2.72923176
100nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.70688570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69120807
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.03728860
3E2F7_22180533_ChIP-Seq_HELA_Human3.73465690
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47936659
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.41545575
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07497869
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96704817
8ZNF274_21170338_ChIP-Seq_K562_Hela2.81608102
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77324291
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72072108
11ELK1_19687146_ChIP-ChIP_HELA_Human2.71874530
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65340308
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55046391
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.51714409
15VDR_23849224_ChIP-Seq_CD4+_Human2.46753155
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.41976945
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40337169
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.39838609
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28087645
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.26679308
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.15525664
22FOXP3_21729870_ChIP-Seq_TREG_Human2.08396648
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.05879700
24EWS_26573619_Chip-Seq_HEK293_Human2.05104569
25VDR_22108803_ChIP-Seq_LS180_Human2.04027176
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00694104
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92253789
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85307379
29IGF1R_20145208_ChIP-Seq_DFB_Human1.82642481
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.80814958
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79083089
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77523975
33MYC_18940864_ChIP-ChIP_HL60_Human1.74603101
34FUS_26573619_Chip-Seq_HEK293_Human1.73375501
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72578736
36DCP1A_22483619_ChIP-Seq_HELA_Human1.72352589
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72277738
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.68619445
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68347108
40IRF1_19129219_ChIP-ChIP_H3396_Human1.67183030
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62320365
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55861359
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53566442
44TAF15_26573619_Chip-Seq_HEK293_Human1.48150048
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47636616
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47581208
47GABP_19822575_ChIP-Seq_HepG2_Human1.47120151
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43993634
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42649570
50P300_19829295_ChIP-Seq_ESCs_Human1.41673057
51AR_21909140_ChIP-Seq_LNCAP_Human1.41454264
52TTF2_22483619_ChIP-Seq_HELA_Human1.41425041
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38520125
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38479126
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38340616
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31065988
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30325502
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30302693
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27866668
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27705537
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27316201
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26539121
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25712213
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.20911628
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.19688058
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18760772
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17617528
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16831273
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.16194582
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10789097
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.08332298
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07864996
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07417750
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07397138
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07101342
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06523949
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.06512318
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.05626576
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02643797
80XRN2_22483619_ChIP-Seq_HELA_Human1.01696400
81ER_23166858_ChIP-Seq_MCF-7_Human1.00927153
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00748048
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00259461
84CIITA_25753668_ChIP-Seq_RAJI_Human0.99819361
85TP53_22573176_ChIP-Seq_HFKS_Human0.98376390
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97536633
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97020725
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.97020725
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93961083
90THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93438457
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.92853742
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90601414
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89505024
94CBP_20019798_ChIP-Seq_JUKART_Human0.87840392
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87840392
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86512891
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.85330072
98NANOG_19829295_ChIP-Seq_ESCs_Human0.84357539
99SOX2_19829295_ChIP-Seq_ESCs_Human0.84357539
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83715111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.76948129
2MP0002102_abnormal_ear_morphology3.56777040
3MP0008058_abnormal_DNA_repair3.54672587
4MP0003693_abnormal_embryo_hatching3.33556269
5MP0008877_abnormal_DNA_methylation3.30036937
6MP0009697_abnormal_copulation3.11925598
7MP0004957_abnormal_blastocyst_morpholog2.99996735
8MP0003011_delayed_dark_adaptation2.78864660
9MP0004147_increased_porphyrin_level2.77246621
10MP0006072_abnormal_retinal_apoptosis2.65783532
11MP0000372_irregular_coat_pigmentation2.59842785
12MP0003718_maternal_effect2.58936117
13MP0003111_abnormal_nucleus_morphology2.40621554
14MP0003077_abnormal_cell_cycle2.31245346
15MP0001529_abnormal_vocalization2.15328330
16MP0005253_abnormal_eye_physiology2.09293533
17MP0008932_abnormal_embryonic_tissue2.04856653
18MP0003786_premature_aging1.96479757
19MP0002751_abnormal_autonomic_nervous1.95984687
20MP0008007_abnormal_cellular_replicative1.90462533
21MP0005084_abnormal_gallbladder_morpholo1.87194820
22MP0003119_abnormal_digestive_system1.86051976
23MP0003890_abnormal_embryonic-extraembry1.83002052
24MP0002736_abnormal_nociception_after1.73654611
25MP0005645_abnormal_hypothalamus_physiol1.71010050
26MP0008057_abnormal_DNA_replication1.56533272
27MP0001293_anophthalmia1.56183570
28MP0006292_abnormal_olfactory_placode1.47669298
29MP0003880_abnormal_central_pattern1.45773712
30MP0008872_abnormal_physiological_respon1.44103574
31MP0006035_abnormal_mitochondrial_morpho1.43061361
32MP0005377_hearing/vestibular/ear_phenot1.42976964
33MP0003878_abnormal_ear_physiology1.42976964
34MP0002234_abnormal_pharynx_morphology1.41331647
35MP0005551_abnormal_eye_electrophysiolog1.40293350
36MP0003937_abnormal_limbs/digits/tail_de1.40137670
37MP0002837_dystrophic_cardiac_calcinosis1.35189704
38MP0008789_abnormal_olfactory_epithelium1.35027114
39MP0003941_abnormal_skin_development1.33234116
40MP0004742_abnormal_vestibular_system1.27548761
41MP0002928_abnormal_bile_duct1.26087729
42MP0002138_abnormal_hepatobiliary_system1.16620409
43MP0006036_abnormal_mitochondrial_physio1.16431461
44MP0005075_abnormal_melanosome_morpholog1.15597121
45MP0001968_abnormal_touch/_nociception1.13191393
46MP0001929_abnormal_gametogenesis1.12586570
47MP0004133_heterotaxia1.12212995
48MP0004142_abnormal_muscle_tone1.12174068
49MP0002938_white_spotting1.08362206
50MP0005391_vision/eye_phenotype1.07764145
51MP0006276_abnormal_autonomic_nervous1.06761517
52MP0001286_abnormal_eye_development1.06506939
53MP0003121_genomic_imprinting1.06070032
54MP0004215_abnormal_myocardial_fiber1.05774373
55MP0005410_abnormal_fertilization1.04766342
56MP0002210_abnormal_sex_determination1.03841661
57MP0003122_maternal_imprinting1.03647294
58MP0000049_abnormal_middle_ear1.03624404
59MP0004197_abnormal_fetal_growth/weight/1.02925975
60MP0001764_abnormal_homeostasis1.00029123
61MP0001177_atelectasis0.98466146
62MP0000350_abnormal_cell_proliferation0.97521501
63MP0005671_abnormal_response_to0.97395277
64MP0008995_early_reproductive_senescence0.97213177
65MP0003950_abnormal_plasma_membrane0.96367471
66MP0002084_abnormal_developmental_patter0.95404818
67MP0009046_muscle_twitch0.93058531
68MP0001984_abnormal_olfaction0.92665327
69MP0001145_abnormal_male_reproductive0.85841695
70MP0002090_abnormal_vision0.83142099
71MP0000653_abnormal_sex_gland0.82736541
72MP0000631_abnormal_neuroendocrine_gland0.82638019
73MP0003195_calcinosis0.82335905
74MP0001697_abnormal_embryo_size0.81823527
75MP0001485_abnormal_pinna_reflex0.81254883
76MP0002085_abnormal_embryonic_tissue0.80986988
77MP0001119_abnormal_female_reproductive0.78782082
78MP0002697_abnormal_eye_size0.78686826
79MP0000613_abnormal_salivary_gland0.78166354
80MP0000358_abnormal_cell_content/0.76027862
81MP0001672_abnormal_embryogenesis/_devel0.75908493
82MP0005380_embryogenesis_phenotype0.75908493
83MP0008775_abnormal_heart_ventricle0.71833571
84MP0002638_abnormal_pupillary_reflex0.71579113
85MP0003698_abnormal_male_reproductive0.69967640
86MP0001188_hyperpigmentation0.68086613
87MP0003943_abnormal_hepatobiliary_system0.67810367
88MP0002111_abnormal_tail_morphology0.67136803
89MP0001730_embryonic_growth_arrest0.65370150
90MP0004782_abnormal_surfactant_physiolog0.65078511
91MP0005395_other_phenotype0.64987341
92MP0002233_abnormal_nose_morphology0.64901453
93MP0003283_abnormal_digestive_organ0.63921866
94MP0009703_decreased_birth_body0.63825879
95MP0008875_abnormal_xenobiotic_pharmacok0.63221428
96MP0003567_abnormal_fetal_cardiomyocyte0.61155643
97MP0002254_reproductive_system_inflammat0.60947088
98MP0005167_abnormal_blood-brain_barrier0.60339459
99MP0002080_prenatal_lethality0.60115442
100MP0005195_abnormal_posterior_eye0.59735056

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.90830612
2Acute necrotizing encephalopathy (HP:0006965)3.54786963
3Hypoplasia of the pons (HP:0012110)3.47150386
4Abnormality of the pons (HP:0007361)3.39727640
5Colon cancer (HP:0003003)3.31070798
6Acute encephalopathy (HP:0006846)3.16862007
7Abnormal mitochondria in muscle tissue (HP:0008316)3.08479190
8Pancreatic cysts (HP:0001737)3.00904783
9Progressive macrocephaly (HP:0004481)2.97418797
10Mitochondrial inheritance (HP:0001427)2.94091103
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.86759539
12Meckel diverticulum (HP:0002245)2.84971545
13Increased CSF lactate (HP:0002490)2.83059900
14Abnormality of the ileum (HP:0001549)2.77334011
15Hypothermia (HP:0002045)2.77230157
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76078350
17Pendular nystagmus (HP:0012043)2.67448383
18Abnormality of midbrain morphology (HP:0002418)2.65476354
19Molar tooth sign on MRI (HP:0002419)2.65476354
20Abnormality of the preputium (HP:0100587)2.59828857
21Chromsome breakage (HP:0040012)2.57776572
22Renal cortical cysts (HP:0000803)2.54955378
23Abnormality of chromosome stability (HP:0003220)2.52656338
24Pancreatic fibrosis (HP:0100732)2.52154143
25Thyroid-stimulating hormone excess (HP:0002925)2.51756064
26Hepatocellular necrosis (HP:0001404)2.50764879
27Ependymoma (HP:0002888)2.50645492
28Increased hepatocellular lipid droplets (HP:0006565)2.46249425
29Cerebral edema (HP:0002181)2.40725176
30Methylmalonic acidemia (HP:0002912)2.40432904
31Lipid accumulation in hepatocytes (HP:0006561)2.39444644
32True hermaphroditism (HP:0010459)2.39046119
33Small intestinal stenosis (HP:0012848)2.32931046
34Duodenal stenosis (HP:0100867)2.32931046
35Congenital, generalized hypertrichosis (HP:0004540)2.32677841
36Hepatic necrosis (HP:0002605)2.32672268
37Short tibia (HP:0005736)2.32276865
38Medial flaring of the eyebrow (HP:0010747)2.27191912
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.26705017
40Chronic hepatic failure (HP:0100626)2.25691082
41Abnormality of the renal cortex (HP:0011035)2.25110725
42Abolished electroretinogram (ERG) (HP:0000550)2.22969123
43Type I transferrin isoform profile (HP:0003642)2.22812853
44Nephronophthisis (HP:0000090)2.21111146
45IgG deficiency (HP:0004315)2.14985312
46Volvulus (HP:0002580)2.13947274
47Increased serum lactate (HP:0002151)2.12582642
48Abnormality of methionine metabolism (HP:0010901)2.12053139
49Carpal bone hypoplasia (HP:0001498)2.11478852
50Abnormality of the duodenum (HP:0002246)2.10889349
51Neonatal respiratory distress (HP:0002643)2.07450628
52Posterior subcapsular cataract (HP:0007787)2.04993341
53Abnormal lung lobation (HP:0002101)2.04157934
54Optic disc pallor (HP:0000543)2.02722330
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02230263
56Sloping forehead (HP:0000340)2.02169861
57Birth length less than 3rd percentile (HP:0003561)2.00501183
58Aplasia/Hypoplasia of the tongue (HP:0010295)1.97702955
59Abnormality of the carotid arteries (HP:0005344)1.97480829
60Abnormal biliary tract physiology (HP:0012439)1.97304207
61Bile duct proliferation (HP:0001408)1.97304207
62Leukodystrophy (HP:0002415)1.96345262
63Duplicated collecting system (HP:0000081)1.95553589
64Progressive inability to walk (HP:0002505)1.94471262
65Attenuation of retinal blood vessels (HP:0007843)1.93219535
66Postnatal microcephaly (HP:0005484)1.92778013
67Abnormality of the renal collecting system (HP:0004742)1.92204561
68Lactic acidosis (HP:0003128)1.92014766
69Clubbing of toes (HP:0100760)1.91672773
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91326658
71Abnormal protein N-linked glycosylation (HP:0012347)1.91326658
72Abnormal protein glycosylation (HP:0012346)1.91326658
73Abnormal glycosylation (HP:0012345)1.91326658
74Absent thumb (HP:0009777)1.90927726
75Triphalangeal thumb (HP:0001199)1.87919920
76Horseshoe kidney (HP:0000085)1.87390444
77Constricted visual fields (HP:0001133)1.87262587
78Sclerocornea (HP:0000647)1.85337316
79Septo-optic dysplasia (HP:0100842)1.85118565
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84681505
81Methylmalonic aciduria (HP:0012120)1.84180903
82Glioma (HP:0009733)1.83996260
83Nephrogenic diabetes insipidus (HP:0009806)1.83674518
84Chorioretinal atrophy (HP:0000533)1.79363318
85Fibular aplasia (HP:0002990)1.79293728
86Anencephaly (HP:0002323)1.78492642
87Congenital primary aphakia (HP:0007707)1.76914380
88Lissencephaly (HP:0001339)1.74486756
89Nephroblastoma (Wilms tumor) (HP:0002667)1.73302894
90Embryonal renal neoplasm (HP:0011794)1.71117637
91Intestinal atresia (HP:0011100)1.70549020
92Lethargy (HP:0001254)1.69102545
93Absent radius (HP:0003974)1.67480119
94Prostate neoplasm (HP:0100787)1.67205571
95Aplasia/hypoplasia of the humerus (HP:0006507)1.67203121
96Prominent metopic ridge (HP:0005487)1.67130335
97Respiratory failure (HP:0002878)1.67034271
98Postaxial foot polydactyly (HP:0001830)1.67028829
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.66949406
100Abnormality of serum amino acid levels (HP:0003112)1.66747910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.74788821
2BUB13.95327030
3TSSK63.15260541
4EIF2AK33.12872476
5SRPK12.84189186
6TRIM282.57461560
7PLK32.45015112
8NUAK12.44528513
9CDC72.41927909
10MKNK12.28056506
11ZAK2.25489070
12VRK22.17788564
13VRK12.12620346
14MST42.06289322
15NEK12.05783548
16BRSK22.04186751
17MKNK22.03094780
18WNK32.02510569
19TXK1.99183388
20TTK1.89535614
21TNIK1.78202981
22TAF11.77671780
23EIF2AK11.73470526
24BCR1.66372340
25PBK1.55867794
26PLK41.49658740
27STK161.48826327
28FRK1.47489277
29ERBB31.38664013
30MAP3K41.34100817
31WEE11.27763087
32GRK11.18201560
33GRK71.17610474
34EIF2AK21.17256046
35CSNK1G11.16562852
36PNCK1.13779728
37TLK11.13347568
38BCKDK1.11035694
39CSNK1G31.05543535
40RPS6KA41.05062544
41NME11.03195772
42PLK11.02586776
43PLK21.01868661
44STK100.99352162
45BRSK10.97890829
46CSNK1G20.97451022
47PASK0.93220466
48CSNK1A1L0.93115821
49OXSR10.92864235
50BMPR1B0.91934276
51AURKB0.91600263
52ADRBK20.85037074
53MAP2K70.84808173
54DYRK30.83460091
55STK38L0.78058057
56NEK20.75511306
57ATR0.71524193
58DAPK10.70294861
59GRK50.69836034
60CHEK20.69579153
61MAPK150.64718656
62ACVR1B0.64705499
63ALK0.63671858
64CDK190.60170669
65KIT0.56653162
66TGFBR10.54833141
67PRKCE0.52834939
68ATM0.50995833
69CCNB10.49599916
70MST1R0.49189416
71SIK30.49079875
72TIE10.48327012
73CHEK10.45801446
74TGFBR20.44065525
75MOS0.42294435
76CSNK2A10.41898900
77FGFR10.40875869
78PAK40.38819294
79CDK30.38628363
80DYRK20.38162478
81INSRR0.37429427
82AURKA0.35291072
83RPS6KA50.33399948
84LATS10.33169773
85CSNK1E0.33077743
86PRKCG0.32142059
87IGF1R0.31929969
88ADRBK10.31331514
89MAPK130.30386950
90TEC0.29946239
91ERBB40.29407342
92CDK60.29171440
93DAPK20.28405167
94STK30.28386080
95CSNK2A20.28341941
96CSNK1A10.27513930
97BRD40.26829202
98MINK10.24864118
99NLK0.24054749
100ITK0.22470471

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28870847
2Protein export_Homo sapiens_hsa030603.27034008
3RNA polymerase_Homo sapiens_hsa030203.21886320
4Mismatch repair_Homo sapiens_hsa034303.17662815
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11051625
6DNA replication_Homo sapiens_hsa030302.92303604
7Homologous recombination_Homo sapiens_hsa034402.45627468
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27152459
9Non-homologous end-joining_Homo sapiens_hsa034502.26440044
10RNA degradation_Homo sapiens_hsa030182.24406700
11Fanconi anemia pathway_Homo sapiens_hsa034602.21320916
12Spliceosome_Homo sapiens_hsa030402.19204992
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15131617
14Basal transcription factors_Homo sapiens_hsa030222.15042515
15RNA transport_Homo sapiens_hsa030131.97133019
16Base excision repair_Homo sapiens_hsa034101.94450430
17Selenocompound metabolism_Homo sapiens_hsa004501.91317791
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91043201
19One carbon pool by folate_Homo sapiens_hsa006701.89370779
20Propanoate metabolism_Homo sapiens_hsa006401.76163380
21Oxidative phosphorylation_Homo sapiens_hsa001901.71487967
22Pyrimidine metabolism_Homo sapiens_hsa002401.68213957
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65198875
24Nucleotide excision repair_Homo sapiens_hsa034201.63162063
25Phototransduction_Homo sapiens_hsa047441.57804784
26Parkinsons disease_Homo sapiens_hsa050121.55974660
27Steroid biosynthesis_Homo sapiens_hsa001001.53691349
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50530236
29Cell cycle_Homo sapiens_hsa041101.44288844
30Caffeine metabolism_Homo sapiens_hsa002321.39655693
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35257938
32Purine metabolism_Homo sapiens_hsa002301.34668092
33Butanoate metabolism_Homo sapiens_hsa006501.26066437
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23856072
35Huntingtons disease_Homo sapiens_hsa050161.20320704
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16583274
37Ribosome_Homo sapiens_hsa030101.10667961
38Pyruvate metabolism_Homo sapiens_hsa006201.10618577
39Vitamin B6 metabolism_Homo sapiens_hsa007501.10143954
40Tryptophan metabolism_Homo sapiens_hsa003801.00293189
41mRNA surveillance pathway_Homo sapiens_hsa030150.99121047
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98452735
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.92678925
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91496773
45Peroxisome_Homo sapiens_hsa041460.90446355
46Alzheimers disease_Homo sapiens_hsa050100.86930114
47Fatty acid elongation_Homo sapiens_hsa000620.84556248
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82923551
49Linoleic acid metabolism_Homo sapiens_hsa005910.82435480
50Oocyte meiosis_Homo sapiens_hsa041140.77464984
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77200506
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76983106
53Glutathione metabolism_Homo sapiens_hsa004800.72537472
54p53 signaling pathway_Homo sapiens_hsa041150.72275322
55Sulfur metabolism_Homo sapiens_hsa009200.71402399
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67499189
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64613765
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64143387
59Metabolic pathways_Homo sapiens_hsa011000.62060383
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61780208
61Ether lipid metabolism_Homo sapiens_hsa005650.59489825
62beta-Alanine metabolism_Homo sapiens_hsa004100.56314769
63Fatty acid degradation_Homo sapiens_hsa000710.54119004
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53482654
65Biosynthesis of amino acids_Homo sapiens_hsa012300.53091048
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52387959
67Chemical carcinogenesis_Homo sapiens_hsa052040.51329673
68Arginine and proline metabolism_Homo sapiens_hsa003300.51268029
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51061064
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50911881
71Retinol metabolism_Homo sapiens_hsa008300.50703304
72Epstein-Barr virus infection_Homo sapiens_hsa051690.50618503
73Nicotine addiction_Homo sapiens_hsa050330.50380030
74Olfactory transduction_Homo sapiens_hsa047400.49569742
75Nitrogen metabolism_Homo sapiens_hsa009100.48903757
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.47146877
77N-Glycan biosynthesis_Homo sapiens_hsa005100.46285527
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45868834
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45642958
80Fatty acid metabolism_Homo sapiens_hsa012120.45624120
81Asthma_Homo sapiens_hsa053100.42500727
82Systemic lupus erythematosus_Homo sapiens_hsa053220.42327199
83Carbon metabolism_Homo sapiens_hsa012000.40470037
84Regulation of autophagy_Homo sapiens_hsa041400.39781487
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38844787
86Primary immunodeficiency_Homo sapiens_hsa053400.37669479
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37653043
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36054735
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34932029
90Taste transduction_Homo sapiens_hsa047420.34090096
91Glycerolipid metabolism_Homo sapiens_hsa005610.31676026
92Antigen processing and presentation_Homo sapiens_hsa046120.31399863
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30837082
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30222680
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29948095
96Fat digestion and absorption_Homo sapiens_hsa049750.26778353
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26417240
98Hedgehog signaling pathway_Homo sapiens_hsa043400.24994318
99Type I diabetes mellitus_Homo sapiens_hsa049400.24367987
100Arachidonic acid metabolism_Homo sapiens_hsa005900.23300062

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