ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neural tube formation (GO:0001841)	4.70255145
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.34904337
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.34904337
4	regulation of translation, ncRNA-mediated (GO:0045974)	4.34904337
5	histone H3-K4 trimethylation (GO:0080182)	4.29857865
6	DNA double-strand break processing (GO:0000729)	3.84508934
7	establishment of protein localization to Golgi (GO:0072600)	3.77968715
8	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.74933169
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73052137
10	regulation of mitotic spindle checkpoint (GO:1903504)	3.69402783
11	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.69402783
12	peptidyl-lysine trimethylation (GO:0018023)	3.56772854
13	centriole replication (GO:0007099)	3.56495563
14	protein targeting to Golgi (GO:0000042)	3.55074403
15	intraciliary transport (GO:0042073)	3.47743471
16	piRNA metabolic process (GO:0034587)	3.46835146
17	gene silencing by RNA (GO:0031047)	3.37441868
18	positive regulation of mRNA processing (GO:0050685)	3.36267447
19	regulation of meiosis I (GO:0060631)	3.32634000
20	regulation of helicase activity (GO:0051095)	3.25711277
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.24021925
22	histone H2A acetylation (GO:0043968)	3.23175426
23	olfactory bulb development (GO:0021772)	3.23119791
24	fucose catabolic process (GO:0019317)	3.19622797
25	L-fucose metabolic process (GO:0042354)	3.19622797
26	L-fucose catabolic process (GO:0042355)	3.19622797
27	epithelial cilium movement (GO:0003351)	3.11313898
28	prenylation (GO:0097354)	3.10529576
29	protein prenylation (GO:0018342)	3.10529576
30	microtubule anchoring (GO:0034453)	3.01663256
31	head development (GO:0060322)	2.99767989
32	nonmotile primary cilium assembly (GO:0035058)	2.99356209
33	positive regulation of mRNA metabolic process (GO:1903313)	2.98679005
34	presynaptic membrane assembly (GO:0097105)	2.98320211
35	acrosome assembly (GO:0001675)	2.96674924
36	cilium or flagellum-dependent cell motility (GO:0001539)	2.91435888
37	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.91383993
38	pyrimidine nucleobase catabolic process (GO:0006208)	2.91093988
39	mRNA splice site selection (GO:0006376)	2.89918723
40	protein localization to Golgi apparatus (GO:0034067)	2.89869068
41	positive regulation of developmental pigmentation (GO:0048087)	2.88694866
42	positive regulation of mRNA 3-end processing (GO:0031442)	2.88035702
43	replication fork processing (GO:0031297)	2.87930724
44	pyrimidine dimer repair (GO:0006290)	2.86956121
45	negative regulation of DNA recombination (GO:0045910)	2.86710714
46	cilium morphogenesis (GO:0060271)	2.86380956
47	DNA methylation involved in gamete generation (GO:0043046)	2.85242087
48	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.81897183
49	positive regulation of histone H3-K4 methylation (GO:0051571)	2.80508927
50	photoreceptor cell maintenance (GO:0045494)	2.78459593
51	DNA demethylation (GO:0080111)	2.77266756
52	synapsis (GO:0007129)	2.77212801
53	pre-miRNA processing (GO:0031054)	2.74496983
54	retinal cone cell development (GO:0046549)	2.73298596
55	monoubiquitinated protein deubiquitination (GO:0035520)	2.72539189
56	single strand break repair (GO:0000012)	2.72147981
57	attachment of spindle microtubules to kinetochore (GO:0008608)	2.69542951
58	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.69296758
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.66004190
60	regulation of mRNA 3-end processing (GO:0031440)	2.64371201
61	regulation of cilium movement (GO:0003352)	2.63081042
62	nuclear pore complex assembly (GO:0051292)	2.61419961
63	protein K11-linked deubiquitination (GO:0035871)	2.61158977
64	reciprocal meiotic recombination (GO:0007131)	2.60988800
65	reciprocal DNA recombination (GO:0035825)	2.60988800
66	behavioral response to ethanol (GO:0048149)	2.59662042
67	hindbrain development (GO:0030902)	2.59544010
68	sympathetic nervous system development (GO:0048485)	2.57776694
69	axoneme assembly (GO:0035082)	2.57679303
70	response to X-ray (GO:0010165)	2.56475646
71	regulation of telomere maintenance (GO:0032204)	2.56103306
72	histone mRNA catabolic process (GO:0071044)	2.55663013
73	cilium organization (GO:0044782)	2.53553995
74	detection of light stimulus involved in visual perception (GO:0050908)	2.53419702
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.53419702
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.51366227
77	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.51366227
78	activated T cell proliferation (GO:0050798)	2.51129679
79	mitotic spindle checkpoint (GO:0071174)	2.49952787
80	nuclear pore organization (GO:0006999)	2.49940942
81	cilium assembly (GO:0042384)	2.49747344
82	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.48382353
83	mitotic sister chromatid cohesion (GO:0007064)	2.48044136
84	cilium movement (GO:0003341)	2.46535136
85	histone H3-K9 methylation (GO:0051567)	2.45741287
86	mismatch repair (GO:0006298)	2.45378684
87	DNA methylation or demethylation (GO:0044728)	2.42859139
88	DNA alkylation (GO:0006305)	2.42597334
89	DNA methylation (GO:0006306)	2.42597334
90	ribonucleoprotein complex disassembly (GO:0032988)	2.42429170
91	intra-Golgi vesicle-mediated transport (GO:0006891)	2.41155541
92	sister chromatid cohesion (GO:0007062)	2.40971040
93	regulation of DNA endoreduplication (GO:0032875)	2.40616996
94	peptidyl-lysine methylation (GO:0018022)	2.40445431
95	organelle disassembly (GO:1903008)	2.39781093
96	double-strand break repair via homologous recombination (GO:0000724)	2.39406833
97	recombinational repair (GO:0000725)	2.39214388
98	presynaptic membrane organization (GO:0097090)	2.39008308
99	regulation of gene silencing by miRNA (GO:0060964)	2.38787149
100	regulation of gene silencing by RNA (GO:0060966)	2.38787149

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.59653254
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23202145
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.10757872
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06207793
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67709453
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64458675
7	FUS_26573619_Chip-Seq_HEK293_Human	2.60036484
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.59546503
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42037670
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.39083104
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36255765
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.35302182
13	EWS_26573619_Chip-Seq_HEK293_Human	2.23016547
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19720004
15	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.18955066
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.17635460
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13336843
18	P300_19829295_ChIP-Seq_ESCs_Human	2.02390571
19	VDR_22108803_ChIP-Seq_LS180_Human	1.96697859
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85638061
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84009803
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83751741
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82626341
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82613252
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82257577
26	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.77861236
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.75588191
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.73251781
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72410027
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71360639
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62807358
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.62552459
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62328555
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59473115
35	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57624234
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.54051495
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53886582
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51796945
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51136604
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48950456
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.47390178
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46934245
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46683578
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45144096
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44998853
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42870991
47	STAT3_23295773_ChIP-Seq_U87_Human	1.41377590
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40159687
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39020774
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.38416342
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38416342
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35219980
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32591579
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32020589
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28503783
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.26920243
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26848605
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25936400
59	TCF4_23295773_ChIP-Seq_U87_Human	1.25238200
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25112534
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25112534
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24999745
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23968525
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22891697
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21120689
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21037198
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20947954
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.20821627
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20447522
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20344903
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.18448157
72	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.17939969
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14454707
74	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13744830
75	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13390607
76	AR_25329375_ChIP-Seq_VCAP_Human	1.12982469
77	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.12096514
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11320117
79	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.10817946
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10148877
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09151090
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07538808
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06698204
84	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.05715076
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05540570
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05311277
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.05130211
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04380952
89	TCF4_22108803_ChIP-Seq_LS180_Human	1.02734233
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02629515
91	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02180003
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01687380
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.00554821
94	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.99297789
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98140967
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97723912
97	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.97073605
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96138015
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95490091
100	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93993525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.40665821
2	MP0002102_abnormal_ear_morphology	3.36931150
3	MP0003787_abnormal_imprinting	3.15004241
4	MP0008057_abnormal_DNA_replication	3.03212989
5	MP0003121_genomic_imprinting	2.75486563
6	MP0008058_abnormal_DNA_repair	2.53354135
7	MP0000569_abnormal_digit_pigmentation	2.52722979
8	MP0003122_maternal_imprinting	2.36945292
9	MP0003890_abnormal_embryonic-extraembry	2.18839329
10	MP0006072_abnormal_retinal_apoptosis	2.09440227
11	MP0006292_abnormal_olfactory_placode	2.07610952
12	MP0001529_abnormal_vocalization	1.98726861
13	MP0008789_abnormal_olfactory_epithelium	1.96912333
14	MP0002751_abnormal_autonomic_nervous	1.95403669
15	MP0000383_abnormal_hair_follicle	1.91918865
16	MP0001984_abnormal_olfaction	1.90408268
17	MP0003567_abnormal_fetal_cardiomyocyte	1.82856984
18	MP0005075_abnormal_melanosome_morpholog	1.82670914
19	MP0003880_abnormal_central_pattern	1.76832101
20	MP0005394_taste/olfaction_phenotype	1.75527682
21	MP0005499_abnormal_olfactory_system	1.75527682
22	MP0010094_abnormal_chromosome_stability	1.72940627
23	MP0008995_early_reproductive_senescence	1.67964801
24	MP0001293_anophthalmia	1.64649571
25	MP0000372_irregular_coat_pigmentation	1.59872787
26	MP0003693_abnormal_embryo_hatching	1.56296985
27	MP0005253_abnormal_eye_physiology	1.55215594
28	MP0002928_abnormal_bile_duct	1.47931946
29	MP0008007_abnormal_cellular_replicative	1.47252886
30	MP0004133_heterotaxia	1.44804890
31	MP0000427_abnormal_hair_cycle	1.43445118
32	MP0003786_premature_aging	1.38645930
33	MP0003718_maternal_effect	1.38068477
34	MP0003943_abnormal_hepatobiliary_system	1.36094785
35	MP0003937_abnormal_limbs/digits/tail_de	1.35727617
36	MP0005551_abnormal_eye_electrophysiolog	1.28894766
37	MP0002233_abnormal_nose_morphology	1.28473378
38	MP0000631_abnormal_neuroendocrine_gland	1.26245213
39	MP0001286_abnormal_eye_development	1.24702362
40	MP0002009_preneoplasia	1.22187288
41	MP0010678_abnormal_skin_adnexa	1.18685085
42	MP0006276_abnormal_autonomic_nervous	1.18159765
43	MP0006035_abnormal_mitochondrial_morpho	1.17630647
44	MP0002277_abnormal_respiratory_mucosa	1.17481121
45	MP0009703_decreased_birth_body	1.14640703
46	MP0000778_abnormal_nervous_system	1.13767792
47	MP0002938_white_spotting	1.12719231
48	MP0003221_abnormal_cardiomyocyte_apopto	1.11795614
49	MP0001929_abnormal_gametogenesis	1.09615183
50	MP0003119_abnormal_digestive_system	1.09124659
51	MP0002396_abnormal_hematopoietic_system	1.08907529
52	MP0003252_abnormal_bile_duct	1.08506464
53	MP0004142_abnormal_muscle_tone	1.07648251
54	MP0003195_calcinosis	1.06424993
55	MP0002084_abnormal_developmental_patter	1.05300856
56	MP0001324_abnormal_eye_pigmentation	1.03849744
57	MP0001188_hyperpigmentation	1.03199373
58	MP0006054_spinal_hemorrhage	1.01965489
59	MP0003077_abnormal_cell_cycle	1.01281943
60	MP0004957_abnormal_blastocyst_morpholog	1.00947980
61	MP0003724_increased_susceptibility_to	1.00890380
62	MP0002736_abnormal_nociception_after	0.94859141
63	MP0002210_abnormal_sex_determination	0.94207477
64	MP0000653_abnormal_sex_gland	0.94118286
65	MP0002638_abnormal_pupillary_reflex	0.93862181
66	MP0008932_abnormal_embryonic_tissue	0.93694778
67	MP0005391_vision/eye_phenotype	0.93518709
68	MP0004197_abnormal_fetal_growth/weight/	0.92069533
69	MP0001145_abnormal_male_reproductive	0.90690627
70	MP0001968_abnormal_touch/_nociception	0.89959388
71	MP0003111_abnormal_nucleus_morphology	0.89103628
72	MP0005248_abnormal_Harderian_gland	0.88773006
73	MP0001177_atelectasis	0.87803993
74	MP0001119_abnormal_female_reproductive	0.87426442
75	MP0005645_abnormal_hypothalamus_physiol	0.85123424
76	MP0000516_abnormal_urinary_system	0.85041842
77	MP0005367_renal/urinary_system_phenotyp	0.85041842
78	MP0003698_abnormal_male_reproductive	0.84948463
79	MP0003861_abnormal_nervous_system	0.84780164
80	MP0000647_abnormal_sebaceous_gland	0.83186965
81	MP0003935_abnormal_craniofacial_develop	0.83012950
82	MP0005084_abnormal_gallbladder_morpholo	0.81760246
83	MP0000015_abnormal_ear_pigmentation	0.81753372
84	MP0005195_abnormal_posterior_eye	0.78834158
85	MP0002234_abnormal_pharynx_morphology	0.77212514
86	MP0002752_abnormal_somatic_nervous	0.77168448
87	MP0004924_abnormal_behavior	0.76534886
88	MP0005386_behavior/neurological_phenoty	0.76534886
89	MP0001986_abnormal_taste_sensitivity	0.76513150
90	MP0001697_abnormal_embryo_size	0.76437489
91	MP0000049_abnormal_middle_ear	0.75030504
92	MP0002088_abnormal_embryonic_growth/wei	0.73278036
93	MP0002085_abnormal_embryonic_tissue	0.73172004
94	MP0002163_abnormal_gland_morphology	0.72776929
95	MP0005671_abnormal_response_to	0.72269817
96	MP0005380_embryogenesis_phenotype	0.72258368
97	MP0001672_abnormal_embryogenesis/_devel	0.72258368
98	MP0000703_abnormal_thymus_morphology	0.71664050
99	MP0003984_embryonic_growth_retardation	0.70271144
100	MP0001486_abnormal_startle_reflex	0.68359973

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	3.33594075
2	Abnormality of macular pigmentation (HP:0008002)	3.32618531
3	Medial flaring of the eyebrow (HP:0010747)	3.28088882
4	Abnormality of midbrain morphology (HP:0002418)	3.05413072
5	Molar tooth sign on MRI (HP:0002419)	3.05413072
6	Central scotoma (HP:0000603)	3.02671237
7	Pancreatic cysts (HP:0001737)	3.02671134
8	Congenital primary aphakia (HP:0007707)	3.01612945
9	Gait imbalance (HP:0002141)	2.97311448
10	Colon cancer (HP:0003003)	2.95038992
11	Nephrogenic diabetes insipidus (HP:0009806)	2.88727361
12	Congenital stationary night blindness (HP:0007642)	2.86575026
13	Pancreatic fibrosis (HP:0100732)	2.82864252
14	Abnormality of the labia minora (HP:0012880)	2.81600807
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.69828623
16	Nephronophthisis (HP:0000090)	2.69544779
17	Genital tract atresia (HP:0001827)	2.67853434
18	Abnormality of the renal cortex (HP:0011035)	2.66442217
19	Intestinal atresia (HP:0011100)	2.63224108
20	Abnormality of the fovea (HP:0000493)	2.61822575
21	Tubulointerstitial nephritis (HP:0001970)	2.59084447
22	Abnormality of the renal medulla (HP:0100957)	2.56238134
23	Severe visual impairment (HP:0001141)	2.55662614
24	Chromsome breakage (HP:0040012)	2.53313205
25	Vaginal atresia (HP:0000148)	2.52029036
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.48705227
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.47830076
28	Hypoplasia of the fovea (HP:0007750)	2.47830076
29	Drooling (HP:0002307)	2.47448774
30	Abnormality of chromosome stability (HP:0003220)	2.42816200
31	True hermaphroditism (HP:0010459)	2.41195574
32	Papillary thyroid carcinoma (HP:0002895)	2.37868627
33	Excessive salivation (HP:0003781)	2.35979198
34	Poor coordination (HP:0002370)	2.34868890
35	Amyotrophic lateral sclerosis (HP:0007354)	2.30117531
36	Chronic hepatic failure (HP:0100626)	2.26307829
37	Scotoma (HP:0000575)	2.25570267
38	Gonadotropin excess (HP:0000837)	2.25250634
39	Abnormal hair whorl (HP:0010721)	2.24538523
40	Abolished electroretinogram (ERG) (HP:0000550)	2.18799302
41	Progressive inability to walk (HP:0002505)	2.13716998
42	Absent speech (HP:0001344)	2.13100772
43	Renal cortical cysts (HP:0000803)	2.12970469
44	Postaxial hand polydactyly (HP:0001162)	2.11914041
45	Oligodactyly (hands) (HP:0001180)	2.10857640
46	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.10771402
47	Astigmatism (HP:0000483)	2.08931284
48	Medulloblastoma (HP:0002885)	2.07139720
49	Short tibia (HP:0005736)	2.06095180
50	Decreased testicular size (HP:0008734)	2.05400478
51	Thyroid carcinoma (HP:0002890)	2.03728905
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03394729
53	Bifid tongue (HP:0010297)	2.00777551
54	Cupped ear (HP:0000378)	1.99342697
55	Attenuation of retinal blood vessels (HP:0007843)	1.98563347
56	Rhabdomyosarcoma (HP:0002859)	1.96385221
57	Abnormal lung lobation (HP:0002101)	1.95174524
58	Stomach cancer (HP:0012126)	1.94570533
59	Hyperventilation (HP:0002883)	1.93608942
60	Embryonal renal neoplasm (HP:0011794)	1.92356598
61	Ectopic kidney (HP:0000086)	1.92109582
62	Broad foot (HP:0001769)	1.91692909
63	Narrow forehead (HP:0000341)	1.91096323
64	Albinism (HP:0001022)	1.90459130
65	Hypochromic microcytic anemia (HP:0004840)	1.89931886
66	Sloping forehead (HP:0000340)	1.89049515
67	Nephroblastoma (Wilms tumor) (HP:0002667)	1.88551460
68	Preaxial hand polydactyly (HP:0001177)	1.88025344
69	Inability to walk (HP:0002540)	1.86435753
70	Widely spaced teeth (HP:0000687)	1.86301055
71	Meckel diverticulum (HP:0002245)	1.85770809
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84433424
73	Short foot (HP:0001773)	1.84407889
74	Neoplasm of the oral cavity (HP:0100649)	1.83889752
75	Median cleft lip (HP:0000161)	1.81880151
76	Micropenis (HP:0000054)	1.80621659
77	Postaxial foot polydactyly (HP:0001830)	1.79888071
78	Growth hormone deficiency (HP:0000824)	1.79295717
79	Stomatitis (HP:0010280)	1.78400789
80	Abnormality of the ileum (HP:0001549)	1.77750587
81	Abnormal biliary tract physiology (HP:0012439)	1.77261964
82	Bile duct proliferation (HP:0001408)	1.77261964
83	Oligodactyly (HP:0012165)	1.76676368
84	Genetic anticipation (HP:0003743)	1.76392373
85	Supernumerary spleens (HP:0009799)	1.76229878
86	Abnormality of the metopic suture (HP:0005556)	1.75488081
87	Tubular atrophy (HP:0000092)	1.75468934
88	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.75286287
89	Labial hypoplasia (HP:0000066)	1.74576842
90	Duodenal stenosis (HP:0100867)	1.73840789
91	Small intestinal stenosis (HP:0012848)	1.73840789
92	Specific learning disability (HP:0001328)	1.73306992
93	Dandy-Walker malformation (HP:0001305)	1.73295163
94	Oculomotor apraxia (HP:0000657)	1.71629834
95	Hepatoblastoma (HP:0002884)	1.71252680
96	Prominent nasal bridge (HP:0000426)	1.71252408
97	Hypothermia (HP:0002045)	1.70821714
98	Tented upper lip vermilion (HP:0010804)	1.70525421
99	Abnormality of the duodenum (HP:0002246)	1.68785837
100	Aqueductal stenosis (HP:0002410)	1.68047044

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.03925448
2	TRIM28	3.37283752
3	WNK3	3.32134281
4	NUAK1	2.95775213
5	TAF1	2.63451585
6	BRD4	2.63137160
7	BCR	2.28370625
8	SRPK1	2.11698569
9	ACVR1B	2.06095705
10	MAP3K4	2.02682029
11	CDK19	1.96104941
12	TNIK	1.88879129
13	BMPR1B	1.82948765
14	CASK	1.79627057
15	PLK4	1.75321174
16	MAP4K2	1.70879664
17	SIK3	1.58851174
18	BRSK2	1.55863080
19	DYRK3	1.50619272
20	MKNK2	1.49122884
21	TXK	1.42667106
22	STK38L	1.40144443
23	MAPK13	1.39987516
24	CSNK1G1	1.38658526
25	OXSR1	1.33705495
26	MKNK1	1.33434440
27	PAK3	1.31925860
28	NLK	1.22367757
29	ERBB3	1.20749994
30	CSNK1G2	1.20144999
31	TAOK3	1.19578122
32	CSNK1A1L	1.17296487
33	CSNK1G3	1.14592381
34	PLK3	1.09988019
35	MARK1	1.09267249
36	DYRK2	1.06733337
37	EIF2AK3	1.04855448
38	ZAK	1.00045079
39	ADRBK2	0.95865927
40	TEC	0.93211885
41	INSRR	0.92992523
42	PLK2	0.91253893
43	YES1	0.88598345
44	BUB1	0.87857000
45	KSR1	0.87709971
46	VRK1	0.85106091
47	GRK1	0.84750248
48	BCKDK	0.82525615
49	RPS6KA4	0.79757716
50	ATR	0.78701792
51	ATM	0.78013914
52	TSSK6	0.75516370
53	FGR	0.73855522
54	PNCK	0.73644098
55	PLK1	0.72251462
56	MAP2K7	0.71147413
57	PINK1	0.69639852
58	MST4	0.69305873
59	CDC7	0.68121448
60	NTRK2	0.67233296
61	FGFR2	0.66876482
62	MAP3K5	0.66105290
63	VRK2	0.65964641
64	DYRK1A	0.65837123
65	STK3	0.64375581
66	PBK	0.59840479
67	MAP3K10	0.59034938
68	CAMKK2	0.57367669
69	PASK	0.56328460
70	STK39	0.54307581
71	PRKCE	0.53181943
72	LATS1	0.51605096
73	SGK2	0.51158339
74	CDK3	0.50173962
75	CHEK1	0.49481175
76	MATK	0.48039689
77	EIF2AK2	0.47868285
78	DYRK1B	0.47840841
79	CDK9	0.47652719
80	AKT3	0.47600405
81	MAP3K7	0.46691592
82	ITK	0.45346395
83	MAP2K4	0.43890333
84	NEK2	0.42135592
85	TTK	0.41827350
86	FLT3	0.41467569
87	PTK2B	0.41318482
88	FGFR1	0.40540471
89	CSNK1D	0.39027073
90	STK24	0.38230847
91	STK11	0.37015958
92	IRAK1	0.36556862
93	RAF1	0.35868728
94	WEE1	0.35249985
95	PRKCQ	0.34763421
96	EGFR	0.34599147
97	NME1	0.34085200
98	EPHA3	0.34021259
99	CDK6	0.33938384
100	CDK8	0.33354516

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.80121961
2	Basal transcription factors_Homo sapiens_hsa03022	3.28493112
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.03102807
4	Homologous recombination_Homo sapiens_hsa03440	2.74537024
5	RNA degradation_Homo sapiens_hsa03018	2.70717187
6	Protein export_Homo sapiens_hsa03060	2.25722881
7	RNA transport_Homo sapiens_hsa03013	2.22598059
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13731548
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.12202189
10	Propanoate metabolism_Homo sapiens_hsa00640	2.11710792
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97854854
12	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.96874577
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.95962571
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89339237
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.85719168
16	Spliceosome_Homo sapiens_hsa03040	1.81851855
17	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.79483970
18	RNA polymerase_Homo sapiens_hsa03020	1.76197425
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.75565798
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.73412021
21	Regulation of autophagy_Homo sapiens_hsa04140	1.69137257
22	Cell cycle_Homo sapiens_hsa04110	1.67260331
23	Phototransduction_Homo sapiens_hsa04744	1.64315347
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52884801
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.44359453
26	Mismatch repair_Homo sapiens_hsa03430	1.38951693
27	Butanoate metabolism_Homo sapiens_hsa00650	1.30371871
28	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.29060117
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.21157555
30	Base excision repair_Homo sapiens_hsa03410	1.18316895
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.17622118
32	Taste transduction_Homo sapiens_hsa04742	1.15959520
33	Proteasome_Homo sapiens_hsa03050	1.14937405
34	p53 signaling pathway_Homo sapiens_hsa04115	1.09552232
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07620492
36	Oocyte meiosis_Homo sapiens_hsa04114	1.04771348
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03233435
38	Measles_Homo sapiens_hsa05162	1.03166936
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01262182
40	Colorectal cancer_Homo sapiens_hsa05210	0.97891065
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93826351
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91182766
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.90649492
44	Nicotine addiction_Homo sapiens_hsa05033	0.89349976
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89225948
46	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83354870
47	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.82137463
48	Circadian rhythm_Homo sapiens_hsa04710	0.81836843
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.78595286
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78313187
51	Purine metabolism_Homo sapiens_hsa00230	0.76619568
52	Serotonergic synapse_Homo sapiens_hsa04726	0.75447449
53	GABAergic synapse_Homo sapiens_hsa04727	0.74402775
54	Morphine addiction_Homo sapiens_hsa05032	0.73300551
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.70675470
56	Axon guidance_Homo sapiens_hsa04360	0.68995947
57	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.67610999
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67004972
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.64693512
60	Adherens junction_Homo sapiens_hsa04520	0.62218195
61	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.61034785
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60412116
63	Olfactory transduction_Homo sapiens_hsa04740	0.59044589
64	ABC transporters_Homo sapiens_hsa02010	0.56127664
65	Herpes simplex infection_Homo sapiens_hsa05168	0.55243232
66	Lysine degradation_Homo sapiens_hsa00310	0.54007521
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53947025
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53002888
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.51527210
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46303102
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45669904
72	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44657007
73	Prostate cancer_Homo sapiens_hsa05215	0.43750548
74	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43560376
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.42854711
76	Thyroid cancer_Homo sapiens_hsa05216	0.41239679
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40816885
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39971242
79	Peroxisome_Homo sapiens_hsa04146	0.39867164
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.39502475
81	Endometrial cancer_Homo sapiens_hsa05213	0.38562399
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.38202870
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38143757
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37795936
85	Prolactin signaling pathway_Homo sapiens_hsa04917	0.35530581
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35495756
87	Long-term depression_Homo sapiens_hsa04730	0.35116453
88	One carbon pool by folate_Homo sapiens_hsa00670	0.35061374
89	MicroRNAs in cancer_Homo sapiens_hsa05206	0.34761101
90	Cholinergic synapse_Homo sapiens_hsa04725	0.33812307
91	Viral carcinogenesis_Homo sapiens_hsa05203	0.32344227
92	Melanoma_Homo sapiens_hsa05218	0.31841294
93	FoxO signaling pathway_Homo sapiens_hsa04068	0.30896993
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29982847
95	Tight junction_Homo sapiens_hsa04530	0.28858082
96	ErbB signaling pathway_Homo sapiens_hsa04012	0.28735511
97	Ras signaling pathway_Homo sapiens_hsa04014	0.26331946
98	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25275957
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.25230585
100	Hepatitis B_Homo sapiens_hsa05161	0.24120327

SUPT20H

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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