ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.73061733
2	response to pheromone (GO:0019236)	4.37660357
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.37169110
4	behavioral response to nicotine (GO:0035095)	4.09799514
5	DNA deamination (GO:0045006)	4.06253868
6	ATP synthesis coupled proton transport (GO:0015986)	3.99507750
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.99507750
8	DNA double-strand break processing (GO:0000729)	3.87217887
9	protein complex biogenesis (GO:0070271)	3.69965910
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.68282007
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.67978034
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.62442429
13	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.56596769
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56030018
15	respiratory chain complex IV assembly (GO:0008535)	3.49234310
16	regulation of meiosis I (GO:0060631)	3.46048355
17	proteasome assembly (GO:0043248)	3.42915491
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.42684550
19	ribosomal small subunit assembly (GO:0000028)	3.40842335
20	replication fork processing (GO:0031297)	3.40623694
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.37677776
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.37677776
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37239667
24	rRNA modification (GO:0000154)	3.36742760
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31733957
26	NADH dehydrogenase complex assembly (GO:0010257)	3.31733957
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31733957
28	rRNA methylation (GO:0031167)	3.28080222
29	synapsis (GO:0007129)	3.27027945
30	CENP-A containing nucleosome assembly (GO:0034080)	3.26398944
31	chromatin remodeling at centromere (GO:0031055)	3.26119676
32	cytochrome complex assembly (GO:0017004)	3.21005058
33	histone H2A acetylation (GO:0043968)	3.18104086
34	respiratory electron transport chain (GO:0022904)	3.17233958
35	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.17054544
36	electron transport chain (GO:0022900)	3.15574123
37	centriole replication (GO:0007099)	3.13762602
38	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.98345017
39	platelet dense granule organization (GO:0060155)	2.97351987
40	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.95042679
41	histone exchange (GO:0043486)	2.94259368
42	chaperone-mediated protein transport (GO:0072321)	2.93453506
43	regulation of cellular amino acid metabolic process (GO:0006521)	2.92423178
44	resolution of meiotic recombination intermediates (GO:0000712)	2.88354793
45	negative regulation of ligase activity (GO:0051352)	2.87810232
46	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.87810232
47	piRNA metabolic process (GO:0034587)	2.87446727
48	regulation of mitotic spindle checkpoint (GO:1903504)	2.86241360
49	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.86241360
50	postreplication repair (GO:0006301)	2.85127247
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83748068
52	protein-cofactor linkage (GO:0018065)	2.83726894
53	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.83358731
54	intraciliary transport (GO:0042073)	2.82693389
55	tachykinin receptor signaling pathway (GO:0007217)	2.81186630
56	anterograde synaptic vesicle transport (GO:0048490)	2.79732115
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.78265992
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.78265992
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.78265992
60	sequestering of actin monomers (GO:0042989)	2.77545702
61	DNA catabolic process, exonucleolytic (GO:0000738)	2.75642858
62	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.75022631
63	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.75022631
64	DNA replication checkpoint (GO:0000076)	2.73430654
65	neural tube formation (GO:0001841)	2.72151120
66	protein polyglutamylation (GO:0018095)	2.70125348
67	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.68187146
68	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.66553598
69	cullin deneddylation (GO:0010388)	2.65217609
70	single strand break repair (GO:0000012)	2.64174288
71	pyrimidine nucleobase catabolic process (GO:0006208)	2.63739931
72	recombinational repair (GO:0000725)	2.62889823
73	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.61737758
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.61737758
75	double-strand break repair via homologous recombination (GO:0000724)	2.61630932
76	histone mRNA metabolic process (GO:0008334)	2.60652233
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.60590984
78	translesion synthesis (GO:0019985)	2.57831838
79	DNA methylation involved in gamete generation (GO:0043046)	2.57774183
80	negative regulation of DNA recombination (GO:0045910)	2.56951318
81	epithelial cilium movement (GO:0003351)	2.56567656
82	protein deneddylation (GO:0000338)	2.54810409
83	reciprocal DNA recombination (GO:0035825)	2.54151260
84	reciprocal meiotic recombination (GO:0007131)	2.54151260
85	positive regulation of ligase activity (GO:0051351)	2.53819857
86	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.51998162
87	cilium morphogenesis (GO:0060271)	2.51572230
88	DNA demethylation (GO:0080111)	2.51554494
89	microtubule depolymerization (GO:0007019)	2.50900314
90	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50268737
91	male meiosis I (GO:0007141)	2.50143485
92	ubiquinone biosynthetic process (GO:0006744)	2.48655266
93	regulation of helicase activity (GO:0051095)	2.48124901
94	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.46447375
95	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.46175599
96	base-excision repair, AP site formation (GO:0006285)	2.43848325
97	mannosylation (GO:0097502)	2.43381442
98	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.43217091
99	termination of RNA polymerase III transcription (GO:0006386)	2.43217091
100	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.42641045

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.70549787
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43212228
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.32842162
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.31430685
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.02661097
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97162910
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83834532
8	VDR_22108803_ChIP-Seq_LS180_Human	2.81587727
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.67446749
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61575686
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.52280473
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.42720516
13	EWS_26573619_Chip-Seq_HEK293_Human	2.42579794
14	* FUS_26573619_Chip-Seq_HEK293_Human	2.24673423
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.23997799
16	* VDR_23849224_ChIP-Seq_CD4+_Human	2.23161499
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20407945
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.10839140
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08893157
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07811002
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.03728422
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02082203
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.00776570
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.98772236
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92235373
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.90084334
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87434567
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87181156
29	P300_19829295_ChIP-Seq_ESCs_Human	1.79803211
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76904924
31	E2F7_22180533_ChIP-Seq_HELA_Human	1.75132873
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68588214
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.68092553
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.67357450
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64683365
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61773526
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.58715035
38	* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52402562
39	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51996498
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.51263394
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47541093
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.46686893
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46442606
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42561181
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.41918009
46	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.38564100
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38102651
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35880182
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34789963
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33915713
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32162948
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31054299
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30347126
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30241774
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28763775
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.28710798
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28710798
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.18127261
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17841582
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16574665
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16574665
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16041953
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12135865
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.11668345
65	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11538756
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10808189
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09669057
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09188566
69	* TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07289333
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06527899
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05707007
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.03751528
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03085407
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01029060
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.00791506
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00681357
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00681357
78	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00581499
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00171303
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00128394
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00045274
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99973506
83	AR_25329375_ChIP-Seq_VCAP_Human	0.99837369
84	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99423466
85	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98359311
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98353060
87	* STAT3_23295773_ChIP-Seq_U87_Human	0.97425627
88	* GABP_19822575_ChIP-Seq_HepG2_Human	0.97244725
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95941427
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95457571
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95435571
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95309284
93	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95127120
94	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.93913269
95	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.93290745
96	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92945739
97	AR_20517297_ChIP-Seq_VCAP_Human	0.92760153
98	* CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92608920
99	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.92181681
100	* TCF4_23295773_ChIP-Seq_U87_Human	0.92155441

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.17159688
2	MP0008877_abnormal_DNA_methylation	3.30199956
3	MP0008058_abnormal_DNA_repair	2.69896855
4	MP0006072_abnormal_retinal_apoptosis	2.46972795
5	MP0002938_white_spotting	2.38600764
6	MP0002102_abnormal_ear_morphology	2.34540512
7	MP0000569_abnormal_digit_pigmentation	2.32259449
8	MP0001529_abnormal_vocalization	2.31343023
9	MP0003880_abnormal_central_pattern	2.31006656
10	MP0003718_maternal_effect	2.20095067
11	MP0008789_abnormal_olfactory_epithelium	2.15293906
12	MP0000372_irregular_coat_pigmentation	2.14590481
13	MP0003121_genomic_imprinting	2.11070861
14	MP0005253_abnormal_eye_physiology	1.88856246
15	MP0003567_abnormal_fetal_cardiomyocyte	1.85565601
16	MP0001984_abnormal_olfaction	1.79971966
17	MP0004147_increased_porphyrin_level	1.76460921
18	MP0003890_abnormal_embryonic-extraembry	1.75809230
19	MP0002160_abnormal_reproductive_system	1.75017797
20	MP0004133_heterotaxia	1.74014023
21	MP0001293_anophthalmia	1.73897885
22	MP0005551_abnormal_eye_electrophysiolog	1.72738356
23	MP0003122_maternal_imprinting	1.72071589
24	MP0005394_taste/olfaction_phenotype	1.71997384
25	MP0005499_abnormal_olfactory_system	1.71997384
26	MP0006276_abnormal_autonomic_nervous	1.70977899
27	MP0009697_abnormal_copulation	1.69626000
28	MP0005646_abnormal_pituitary_gland	1.69106076
29	MP0002736_abnormal_nociception_after	1.68928256
30	MP0003787_abnormal_imprinting	1.68667549
31	MP0003136_yellow_coat_color	1.66149087
32	MP0008995_early_reproductive_senescence	1.63512624
33	MP0003786_premature_aging	1.62559503
34	MP0001968_abnormal_touch/_nociception	1.54873164
35	MP0002751_abnormal_autonomic_nervous	1.54563823
36	MP0004142_abnormal_muscle_tone	1.54406440
37	MP0010094_abnormal_chromosome_stability	1.52133566
38	MP0002234_abnormal_pharynx_morphology	1.51314405
39	MP0005389_reproductive_system_phenotype	1.47877832
40	MP0005410_abnormal_fertilization	1.44980276
41	MP0001929_abnormal_gametogenesis	1.41680342
42	MP0002210_abnormal_sex_determination	1.39936111
43	MP0003693_abnormal_embryo_hatching	1.33768691
44	MP0005423_abnormal_somatic_nervous	1.31710733
45	MP0000631_abnormal_neuroendocrine_gland	1.30432425
46	MP0005645_abnormal_hypothalamus_physiol	1.28816062
47	MP0008932_abnormal_embryonic_tissue	1.22199273
48	MP0004957_abnormal_blastocyst_morpholog	1.22092488
49	MP0002163_abnormal_gland_morphology	1.21803070
50	MP0005084_abnormal_gallbladder_morpholo	1.21524211
51	MP0000653_abnormal_sex_gland	1.20078439
52	MP0000778_abnormal_nervous_system	1.18498674
53	MP0001145_abnormal_male_reproductive	1.17494742
54	MP0008007_abnormal_cellular_replicative	1.16762273
55	MP0003119_abnormal_digestive_system	1.16302890
56	MP0010386_abnormal_urinary_bladder	1.16164448
57	MP0005391_vision/eye_phenotype	1.14259501
58	MP0002638_abnormal_pupillary_reflex	1.14221076
59	MP0005367_renal/urinary_system_phenotyp	1.14068840
60	MP0000516_abnormal_urinary_system	1.14068840
61	MP0009046_muscle_twitch	1.12858587
62	MP0008872_abnormal_physiological_respon	1.10638655
63	MP0003698_abnormal_male_reproductive	1.10582743
64	MP0006035_abnormal_mitochondrial_morpho	1.08709943
65	MP0003937_abnormal_limbs/digits/tail_de	1.08568751
66	MP0003111_abnormal_nucleus_morphology	1.06491720
67	MP0001919_abnormal_reproductive_system	1.06233636
68	MP0002272_abnormal_nervous_system	1.04273368
69	MP0001119_abnormal_female_reproductive	1.04114209
70	MP0001764_abnormal_homeostasis	1.03879344
71	MP0000647_abnormal_sebaceous_gland	1.01187008
72	MP0001485_abnormal_pinna_reflex	0.99222980
73	MP0009745_abnormal_behavioral_response	0.99017827
74	MP0002557_abnormal_social/conspecific_i	0.97327023
75	MP0001286_abnormal_eye_development	0.96697504
76	MP0008875_abnormal_xenobiotic_pharmacok	0.94703010
77	MP0003195_calcinosis	0.94480707
78	MP0003077_abnormal_cell_cycle	0.94045161
79	MP0005195_abnormal_posterior_eye	0.92582249
80	MP0002233_abnormal_nose_morphology	0.91482690
81	MP0002735_abnormal_chemical_nociception	0.89312213
82	MP0002095_abnormal_skin_pigmentation	0.89059018
83	MP0000049_abnormal_middle_ear	0.89042990
84	MP0004215_abnormal_myocardial_fiber	0.88729748
85	MP0001905_abnormal_dopamine_level	0.86961085
86	MP0003186_abnormal_redox_activity	0.83779190
87	MP0002822_catalepsy	0.81913350
88	MP0002752_abnormal_somatic_nervous	0.81498822
89	MP0001486_abnormal_startle_reflex	0.79771418
90	MP0002572_abnormal_emotion/affect_behav	0.78632613
91	MP0002067_abnormal_sensory_capabilities	0.76421641
92	MP0004742_abnormal_vestibular_system	0.71139204
93	MP0006036_abnormal_mitochondrial_physio	0.71009341
94	MP0002184_abnormal_innervation	0.70621943
95	MP0002161_abnormal_fertility/fecundity	0.70121530
96	MP0008057_abnormal_DNA_replication	0.69587010
97	MP0002837_dystrophic_cardiac_calcinosis	0.68531354
98	MP0005075_abnormal_melanosome_morpholog	0.67734226
99	MP0000639_abnormal_adrenal_gland	0.67057999
100	MP0005174_abnormal_tail_pigmentation	0.66660232

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.04814128
2	Pancreatic cysts (HP:0001737)	3.72853060
3	True hermaphroditism (HP:0010459)	3.69444269
4	Acute necrotizing encephalopathy (HP:0006965)	3.30513713
5	Mitochondrial inheritance (HP:0001427)	3.11679836
6	Renal cortical cysts (HP:0000803)	3.07029143
7	Molar tooth sign on MRI (HP:0002419)	3.02761151
8	Abnormality of midbrain morphology (HP:0002418)	3.02761151
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02068008
10	Increased hepatocellular lipid droplets (HP:0006565)	3.00066978
11	Progressive macrocephaly (HP:0004481)	2.93207037
12	Increased CSF lactate (HP:0002490)	2.87744642
13	Acute encephalopathy (HP:0006846)	2.84890655
14	Congenital stationary night blindness (HP:0007642)	2.77535982
15	Methylmalonic acidemia (HP:0002912)	2.76725016
16	Hepatocellular necrosis (HP:0001404)	2.76144596
17	Hepatic necrosis (HP:0002605)	2.73380794
18	Sclerocornea (HP:0000647)	2.69262747
19	Medial flaring of the eyebrow (HP:0010747)	2.65586959
20	Lipid accumulation in hepatocytes (HP:0006561)	2.64096504
21	Postaxial foot polydactyly (HP:0001830)	2.63416781
22	3-Methylglutaconic aciduria (HP:0003535)	2.59905875
23	Colon cancer (HP:0003003)	2.58618156
24	Chronic hepatic failure (HP:0100626)	2.58427301
25	Meckel diverticulum (HP:0002245)	2.56332854
26	Abnormality of the labia minora (HP:0012880)	2.55746346
27	Nephronophthisis (HP:0000090)	2.51187946
28	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.49173827
29	Generalized aminoaciduria (HP:0002909)	2.46973707
30	Pendular nystagmus (HP:0012043)	2.46835333
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.45026971
32	Abnormality of the ileum (HP:0001549)	2.42794626
33	Renal Fanconi syndrome (HP:0001994)	2.40755567
34	Abnormality of the renal cortex (HP:0011035)	2.39621971
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.29238331
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.29238331
37	Median cleft lip (HP:0000161)	2.27266150
38	Preaxial hand polydactyly (HP:0001177)	2.25758694
39	Hyperglycinemia (HP:0002154)	2.24798409
40	Abnormality of the renal medulla (HP:0100957)	2.24358516
41	Aplastic anemia (HP:0001915)	2.23569851
42	Congenital primary aphakia (HP:0007707)	2.22374821
43	Supernumerary spleens (HP:0009799)	2.22288663
44	Methylmalonic aciduria (HP:0012120)	2.21083733
45	Short tibia (HP:0005736)	2.20900031
46	Cystic liver disease (HP:0006706)	2.19821206
47	Oligodactyly (hands) (HP:0001180)	2.19689410
48	Gait imbalance (HP:0002141)	2.19439474
49	Nephrogenic diabetes insipidus (HP:0009806)	2.18700064
50	Genital tract atresia (HP:0001827)	2.18632187
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16968023
52	Abnormal biliary tract physiology (HP:0012439)	2.15926043
53	Bile duct proliferation (HP:0001408)	2.15926043
54	Anencephaly (HP:0002323)	2.15356186
55	Abnormality of chromosome stability (HP:0003220)	2.13702314
56	Abnormal lung lobation (HP:0002101)	2.12998365
57	Bifid tongue (HP:0010297)	2.11540688
58	Abolished electroretinogram (ERG) (HP:0000550)	2.09216250
59	Increased intramyocellular lipid droplets (HP:0012240)	2.05720509
60	Postaxial hand polydactyly (HP:0001162)	2.03565199
61	Small intestinal stenosis (HP:0012848)	2.00791930
62	Duodenal stenosis (HP:0100867)	2.00791930
63	Cerebral edema (HP:0002181)	2.00701144
64	Vaginal atresia (HP:0000148)	1.99386426
65	Attenuation of retinal blood vessels (HP:0007843)	1.97907366
66	Increased serum lactate (HP:0002151)	1.97811451
67	Optic nerve hypoplasia (HP:0000609)	1.97757647
68	Optic disc pallor (HP:0000543)	1.97294605
69	Chromsome breakage (HP:0040012)	1.96670190
70	Congenital hepatic fibrosis (HP:0002612)	1.92157590
71	Reticulocytopenia (HP:0001896)	1.92042319
72	Male pseudohermaphroditism (HP:0000037)	1.91669278
73	Abnormality of the preputium (HP:0100587)	1.91659234
74	Septo-optic dysplasia (HP:0100842)	1.91490956
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.91483605
76	Glycosuria (HP:0003076)	1.90700018
77	Abnormality of urine glucose concentration (HP:0011016)	1.90700018
78	Lissencephaly (HP:0001339)	1.88985364
79	Abnormality of the fovea (HP:0000493)	1.88432020
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.88239127
81	Sloping forehead (HP:0000340)	1.87690328
82	Abnormal number of erythroid precursors (HP:0012131)	1.87255662
83	Type II lissencephaly (HP:0007260)	1.86039543
84	Abnormality of the duodenum (HP:0002246)	1.84388224
85	Hypothermia (HP:0002045)	1.83566434
86	Abdominal situs inversus (HP:0003363)	1.80965463
87	Abnormality of abdominal situs (HP:0011620)	1.80965463
88	Exertional dyspnea (HP:0002875)	1.79881505
89	Dandy-Walker malformation (HP:0001305)	1.78613440
90	Lactic acidosis (HP:0003128)	1.78310765
91	Stenosis of the external auditory canal (HP:0000402)	1.76922714
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.76150060
93	Abnormality of the pons (HP:0007361)	1.74548340
94	Triphalangeal thumb (HP:0001199)	1.73543222
95	Absent thumb (HP:0009777)	1.71801876
96	Hypoplasia of the fovea (HP:0007750)	1.70864676
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.70864676
98	Tubulointerstitial nephritis (HP:0001970)	1.70626110
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70273089
100	Abnormality of cells of the erythroid lineage (HP:0012130)	1.69878526

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.37071161
2	VRK2	2.51273072
3	SRPK1	2.44876242
4	ZAK	2.37652528
5	WNK3	2.24702655
6	FRK	2.24306123
7	TRIM28	2.20765538
8	NUAK1	2.13687587
9	BMPR1B	2.12822494
10	MST4	2.08124104
11	TXK	2.02686335
12	PLK4	1.97340368
13	VRK1	1.97299904
14	EIF2AK3	1.85579294
15	BUB1	1.82537088
16	CDK19	1.81775803
17	DYRK2	1.78169388
18	PINK1	1.77890572
19	MAP3K4	1.64805844
20	PLK3	1.64655472
21	BCR	1.64012369
22	STK16	1.61727637
23	TNIK	1.61455028
24	MAPK13	1.61184520
25	ERBB3	1.53977947
26	GRK1	1.52994923
27	ADRBK2	1.45637673
28	MAP2K7	1.39467637
29	KDR	1.39194569
30	TLK1	1.38360983
31	MKNK2	1.38273346
32	TAOK3	1.35695950
33	WNK4	1.33418805
34	CDC7	1.33144907
35	BRSK2	1.32500249
36	CSNK1G2	1.24154217
37	MKNK1	1.22312846
38	PLK2	1.20922920
39	BCKDK	1.18652893
40	ACVR1B	1.17924645
41	PNCK	1.16874695
42	TAF1	1.15685627
43	NME1	1.15518708
44	PASK	1.15266819
45	CSNK1G1	1.15028185
46	TTK	1.14004366
47	WEE1	1.09986519
48	FLT3	1.09359232
49	OXSR1	1.08541268
50	CSNK1G3	1.08190352
51	PLK1	1.07107293
52	CASK	1.03301241
53	CSNK1A1L	1.03061641
54	STK39	0.90274740
55	EPHA4	0.89168099
56	TGFBR1	0.89068715
57	MARK1	0.78921663
58	AURKA	0.78103271
59	CAMKK2	0.76439281
60	TSSK6	0.76210669
61	ATR	0.75323787
62	NEK1	0.75112761
63	DYRK3	0.69272885
64	CHEK2	0.69226511
65	INSRR	0.67748016
66	NTRK2	0.67515303
67	PRKCG	0.65894170
68	PBK	0.62520233
69	AURKB	0.60519904
70	ATM	0.60139255
71	TIE1	0.58372560
72	EIF2AK1	0.54442155
73	CLK1	0.54155286
74	RPS6KA4	0.52546310
75	CDK3	0.50430996
76	CSNK2A1	0.47813290
77	CSNK1A1	0.46026452
78	TESK2	0.45208096
79	RPS6KA5	0.44269328
80	PRKCE	0.43913184
81	EIF2AK2	0.42730306
82	DAPK1	0.42114268
83	PRKCQ	0.41141511
84	CAMK2A	0.41093059
85	PKN1	0.40927475
86	CSNK2A2	0.40018438
87	MAP3K12	0.39649930
88	MINK1	0.37866422
89	NEK2	0.37447057
90	PRKACA	0.36651602
91	BRSK1	0.34744534
92	CDK8	0.34652358
93	CHEK1	0.33970546
94	ADRBK1	0.33196458
95	NEK6	0.30300679
96	GRK5	0.30297769
97	PRKACB	0.30280255
98	CCNB1	0.29760942
99	PAK3	0.27790150
100	GRK7	0.27652622

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.01107646
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27170844
3	Protein export_Homo sapiens_hsa03060	3.18027623
4	Homologous recombination_Homo sapiens_hsa03440	2.99810408
5	Parkinsons disease_Homo sapiens_hsa05012	2.90650151
6	Ribosome_Homo sapiens_hsa03010	2.86614947
7	Mismatch repair_Homo sapiens_hsa03430	2.53541641
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.52796765
9	Basal transcription factors_Homo sapiens_hsa03022	2.46337546
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32805355
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15069401
12	RNA polymerase_Homo sapiens_hsa03020	2.08788655
13	RNA degradation_Homo sapiens_hsa03018	2.06716026
14	Huntingtons disease_Homo sapiens_hsa05016	2.01371641
15	DNA replication_Homo sapiens_hsa03030	1.97225442
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.90237414
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.89949708
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83900860
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.82338186
20	Propanoate metabolism_Homo sapiens_hsa00640	1.76231121
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.73643017
22	Phototransduction_Homo sapiens_hsa04744	1.73365299
23	Alzheimers disease_Homo sapiens_hsa05010	1.71911303
24	RNA transport_Homo sapiens_hsa03013	1.68304604
25	Base excision repair_Homo sapiens_hsa03410	1.61561712
26	Spliceosome_Homo sapiens_hsa03040	1.59146706
27	Butanoate metabolism_Homo sapiens_hsa00650	1.57616496
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.53429384
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49233802
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32621815
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31533748
32	Nicotine addiction_Homo sapiens_hsa05033	1.25749500
33	Caffeine metabolism_Homo sapiens_hsa00232	1.22115255
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18561412
35	One carbon pool by folate_Homo sapiens_hsa00670	1.18405105
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.16765029
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13801485
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10092693
39	Purine metabolism_Homo sapiens_hsa00230	1.09453081
40	Regulation of autophagy_Homo sapiens_hsa04140	1.07550320
41	Peroxisome_Homo sapiens_hsa04146	1.05007116
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01970458
43	Cell cycle_Homo sapiens_hsa04110	0.99949800
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.97383001
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93941843
46	Olfactory transduction_Homo sapiens_hsa04740	0.93565404
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92581210
48	Fatty acid elongation_Homo sapiens_hsa00062	0.87463188
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.83070168
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79893589
51	Taste transduction_Homo sapiens_hsa04742	0.79590289
52	Oocyte meiosis_Homo sapiens_hsa04114	0.79526985
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79255176
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78355089
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77572391
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.76554576
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71885340
58	Metabolic pathways_Homo sapiens_hsa01100	0.70224726
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67623260
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66894229
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66577524
62	Retinol metabolism_Homo sapiens_hsa00830	0.66398635
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64480751
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64080145
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63850257
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62977669
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61386522
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60717066
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60418021
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57705633
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.57553605
72	Folate biosynthesis_Homo sapiens_hsa00790	0.55544772
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54869483
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54521109
75	Glutathione metabolism_Homo sapiens_hsa00480	0.52309593
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50992621
77	GABAergic synapse_Homo sapiens_hsa04727	0.48700078
78	Morphine addiction_Homo sapiens_hsa05032	0.47599768
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47443840
80	p53 signaling pathway_Homo sapiens_hsa04115	0.46261507
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.46183486
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44448513
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.42011903
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.41896036
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40346018
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39702189
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.35940757
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32986664
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30916362
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.29989502
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27590629
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.27384342
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.25546595
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25486528
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24313560
96	Fatty acid degradation_Homo sapiens_hsa00071	0.24288809
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.23084802
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.19977217
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.19958072
100	Circadian entrainment_Homo sapiens_hsa04713	0.17745674

SUPT3H

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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