SUPT4H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.30536015
2viral transcription (GO:0019083)4.89612906
3translational termination (GO:0006415)4.55484887
4neutrophil activation involved in immune response (GO:0002283)4.27179570
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98359525
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.98359525
7modulation by symbiont of host immune response (GO:0052553)3.98359525
8positive regulation by symbiont of host defense response (GO:0052509)3.98359525
9modulation by symbiont of host defense response (GO:0052031)3.98359525
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98359525
11translational elongation (GO:0006414)3.96234483
12viral life cycle (GO:0019058)3.90297793
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79506618
14maturation of SSU-rRNA (GO:0030490)3.77470366
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75416769
16negative regulation of cell killing (GO:0031342)3.75416769
17protein targeting to ER (GO:0045047)3.74416287
18ribosomal small subunit assembly (GO:0000028)3.69160726
19cotranslational protein targeting to membrane (GO:0006613)3.69159074
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.66868451
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63953623
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58850470
23protein localization to endoplasmic reticulum (GO:0070972)3.58142055
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57904785
25cellular protein complex disassembly (GO:0043624)3.53947307
26positive regulation of gamma-delta T cell activation (GO:0046645)3.33478672
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32059768
28negative regulation of erythrocyte differentiation (GO:0045647)3.21850748
29regulation of mast cell degranulation (GO:0043304)3.18298086
30response to peptidoglycan (GO:0032494)3.17307181
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17013971
32protein complex disassembly (GO:0043241)3.16064454
33translational initiation (GO:0006413)3.08839084
34positive regulation of mast cell activation (GO:0033005)3.05103986
35viral protein processing (GO:0019082)3.04849590
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.03062413
37detection of other organism (GO:0098543)3.00257136
38virion assembly (GO:0019068)2.97476296
39macromolecular complex disassembly (GO:0032984)2.96036298
40response to host immune response (GO:0052572)2.95716716
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95716716
42ribosomal large subunit biogenesis (GO:0042273)2.93710242
43neutrophil activation (GO:0042119)2.93017977
44respiratory burst (GO:0045730)2.90258510
45granulocyte activation (GO:0036230)2.89257342
46detection of bacterium (GO:0016045)2.86801054
47protein maturation by protein folding (GO:0022417)2.85126023
48leukocyte aggregation (GO:0070486)2.84705779
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81778572
50regulation of mast cell activation involved in immune response (GO:0033006)2.79510775
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79158432
52negative regulation of interleukin-12 production (GO:0032695)2.78935918
53protein targeting to membrane (GO:0006612)2.78590260
54Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78208692
55antigen processing and presentation of endogenous antigen (GO:0019883)2.78002086
56leukocyte migration involved in inflammatory response (GO:0002523)2.77883276
57response to host (GO:0075136)2.75510426
58response to host defenses (GO:0052200)2.75510426
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75510426
60pentose metabolic process (GO:0019321)2.75098034
61positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74681887
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73057243
63regulation of leukocyte degranulation (GO:0043300)2.72036189
64pyrimidine nucleotide catabolic process (GO:0006244)2.71621591
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70100052
66regulation of defense response to virus by virus (GO:0050690)2.70022806
67regulation of B cell receptor signaling pathway (GO:0050855)2.67890126
68pentose-phosphate shunt (GO:0006098)2.66412646
69regulation of superoxide anion generation (GO:0032928)2.65784198
703-UTR-mediated mRNA stabilization (GO:0070935)2.62501810
71negative regulation of myeloid cell apoptotic process (GO:0033033)2.62476419
72ribonucleoprotein complex biogenesis (GO:0022613)2.61157387
73cellular extravasation (GO:0045123)2.58318306
74positive regulation of mast cell activation involved in immune response (GO:0033008)2.55268619
75positive regulation of mast cell degranulation (GO:0043306)2.55268619
76antigen processing and presentation via MHC class Ib (GO:0002475)2.54882564
77immunoglobulin mediated immune response (GO:0016064)2.53248577
78regulation of interferon-beta biosynthetic process (GO:0045357)2.52347685
79detection of external biotic stimulus (GO:0098581)2.48872025
80chaperone-mediated protein transport (GO:0072321)2.47124018
81leukocyte degranulation (GO:0043299)2.45572576
82mitochondrial calcium ion transport (GO:0006851)2.45186945
83positive regulation of protein homooligomerization (GO:0032464)2.44553476
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43880928
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42850753
86modulation by virus of host process (GO:0019054)2.42567844
87translation (GO:0006412)2.41774290
88myeloid cell activation involved in immune response (GO:0002275)2.41273766
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37703917
90regulation of mast cell activation (GO:0033003)2.37653235
91ATP synthesis coupled proton transport (GO:0015986)2.34831000
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.34831000
93detection of molecule of bacterial origin (GO:0032490)2.34274911
94regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.33747645
95cellular response to virus (GO:0098586)2.33038152
96pinocytosis (GO:0006907)2.32931401
97NIK/NF-kappaB signaling (GO:0038061)2.32218472
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.32170532
99lipoxygenase pathway (GO:0019372)2.31753507
100protein neddylation (GO:0045116)2.30585667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26130956
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.89722471
3ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86588005
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53227110
5* VDR_21846776_ChIP-Seq_THP-1_Human2.35555124
6MYC_22102868_ChIP-Seq_BL_Human2.11966660
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.11179768
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07125829
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04706358
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00768358
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96384702
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92363664
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92335883
14MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92090793
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89909028
16* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87255318
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87235271
18* SPI1_23547873_ChIP-Seq_NB4_Human1.76833083
19XRN2_22483619_ChIP-Seq_HELA_Human1.76761722
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.75581518
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72798649
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68193553
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.65779387
24MAF_26560356_Chip-Seq_TH1_Human1.63364593
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.60337933
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.59229139
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58670162
28* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58372816
29* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57817157
30* UTX_26944678_Chip-Seq_JUKART_Human1.57295355
31VDR_24763502_ChIP-Seq_THP-1_Human1.56751075
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56013677
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55786062
34* GABP_17652178_ChIP-ChIP_JURKAT_Human1.55769529
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55555208
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.55479115
37LXR_22292898_ChIP-Seq_THP-1_Human1.55267130
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49758256
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49564313
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49051319
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48439648
42* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48063451
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47758437
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47259864
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46195812
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.45057717
47MAF_26560356_Chip-Seq_TH2_Human1.42649548
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40783284
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40700512
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39656442
51CIITA_25753668_ChIP-Seq_RAJI_Human1.36772687
52* EST1_17652178_ChIP-ChIP_JURKAT_Human1.36244353
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35443950
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.35297461
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34867566
56* GABP_19822575_ChIP-Seq_HepG2_Human1.33562786
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33524321
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32417384
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32065580
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31813142
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31360017
62* DCP1A_22483619_ChIP-Seq_HELA_Human1.30611283
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30206944
64TCF7_22412390_ChIP-Seq_EML_Mouse1.29956662
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29450301
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27586633
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27199254
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26198280
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25463644
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25155254
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25012626
72TFEB_21752829_ChIP-Seq_HELA_Human1.24302602
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23628887
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23543662
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23181975
76ZNF263_19887448_ChIP-Seq_K562_Human1.23104850
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22887007
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20386704
79NCOR1_26117541_ChIP-Seq_K562_Human1.19891934
80* FOXP3_21729870_ChIP-Seq_TREG_Human1.19721121
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19210105
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17551404
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16340525
84RACK7_27058665_Chip-Seq_MCF-7_Human1.16315813
85* SPI1_23127762_ChIP-Seq_K562_Human1.15802124
86* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14595028
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.13898980
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13863455
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.13621021
90* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13425248
91E2F7_22180533_ChIP-Seq_HELA_Human1.13168651
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12426248
93BCL6_27268052_Chip-Seq_Bcells_Human1.11317305
94* TTF2_22483619_ChIP-Seq_HELA_Human1.10723940
95SCL_19346495_ChIP-Seq_HPC-7_Human1.10514602
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.09911916
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09665747
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09398030
99KDM2B_26808549_Chip-Seq_DND41_Human1.09176806
100BCOR_27268052_Chip-Seq_Bcells_Human1.09073339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.91129120
2MP0003436_decreased_susceptibility_to3.43257696
3MP0005058_abnormal_lysosome_morphology3.33669438
4MP0008260_abnormal_autophagy2.97998104
5MP0001835_abnormal_antigen_presentation2.84296519
6MP0003303_peritoneal_inflammation2.78764335
7MP0003724_increased_susceptibility_to2.61368065
8MP0003191_abnormal_cellular_cholesterol2.59469042
9MP0005451_abnormal_body_composition2.42270205
10MP0009333_abnormal_splenocyte_physiolog2.39587775
11MP0005000_abnormal_immune_tolerance2.32902142
12MP0005025_abnormal_response_to2.31068337
13MP0003806_abnormal_nucleotide_metabolis2.30349907
14MP0009379_abnormal_foot_pigmentation2.22273148
15MP0002419_abnormal_innate_immunity2.19657354
16MP0005671_abnormal_response_to2.19155330
17MP0000685_abnormal_immune_system2.18063470
18MP0001800_abnormal_humoral_immune2.17655791
19MP0002148_abnormal_hypersensitivity_rea2.10922658
20MP0002723_abnormal_immune_serum2.07665102
21MP0002420_abnormal_adaptive_immunity2.04508519
22MP0009785_altered_susceptibility_to2.03467106
23MP0001819_abnormal_immune_cell2.02599735
24MP0002452_abnormal_antigen_presenting1.97771920
25MP0002398_abnormal_bone_marrow1.91110529
26MP0001790_abnormal_immune_system1.88866627
27MP0005387_immune_system_phenotype1.88866627
28MP0005083_abnormal_biliary_tract1.83499747
29MP0002132_abnormal_respiratory_system1.78873102
30MP0000858_altered_metastatic_potential1.78137414
31MP0006082_CNS_inflammation1.76417635
32MP0004947_skin_inflammation1.75009964
33MP0000716_abnormal_immune_system1.71370202
34MP0003763_abnormal_thymus_physiology1.69866391
35MP0002429_abnormal_blood_cell1.63870834
36MP0000343_altered_response_to1.63487233
37MP0002722_abnormal_immune_system1.61792387
38MP0000689_abnormal_spleen_morphology1.55424374
39MP0001845_abnormal_inflammatory_respons1.53271626
40MP0000703_abnormal_thymus_morphology1.53084816
41MP0010155_abnormal_intestine_physiology1.51404175
42MP0002877_abnormal_melanocyte_morpholog1.50284149
43MP0001533_abnormal_skeleton_physiology1.48962047
44MP0003866_abnormal_defecation1.48655327
45MP0002405_respiratory_system_inflammati1.45788295
46MP0009840_abnormal_foam_cell1.42614706
47MP0000490_abnormal_crypts_of1.41921804
48MP0003300_gastrointestinal_ulcer1.41425633
49MP0006036_abnormal_mitochondrial_physio1.35053544
50MP0003656_abnormal_erythrocyte_physiolo1.32936174
51MP0005501_abnormal_skin_physiology1.31408029
52MP0001853_heart_inflammation1.31217292
53MP0003172_abnormal_lysosome_physiology1.29207652
54MP0003123_paternal_imprinting1.27095590
55MP0008469_abnormal_protein_level1.26916329
56MP0003186_abnormal_redox_activity1.22319288
57MP0001348_abnormal_lacrimal_gland1.21322249
58MP0004957_abnormal_blastocyst_morpholog1.21184913
59MP0004185_abnormal_adipocyte_glucose1.20385681
60MP0009764_decreased_sensitivity_to1.19714092
61MP0009278_abnormal_bone_marrow1.18811247
62MP0003828_pulmonary_edema1.17905888
63MP0003705_abnormal_hypodermis_morpholog1.11210534
64MP0008004_abnormal_stomach_pH1.07831337
65MP0006035_abnormal_mitochondrial_morpho1.05907711
66MP0003183_abnormal_peptide_metabolism1.00894080
67MP0003075_altered_response_to1.00889918
68MP0000313_abnormal_cell_death0.99935175
69MP0009763_increased_sensitivity_to0.99921698
70MP0001545_abnormal_hematopoietic_system0.99126436
71MP0005397_hematopoietic_system_phenotyp0.99126436
72MP0009765_abnormal_xenobiotic_induced0.98626500
73MP0000465_gastrointestinal_hemorrhage0.98411594
74MP0003221_abnormal_cardiomyocyte_apopto0.97848624
75MP0001727_abnormal_embryo_implantation0.97765254
76MP0002796_impaired_skin_barrier0.95845942
77MP0001663_abnormal_digestive_system0.95364299
78MP0004510_myositis0.95234471
79MP0002019_abnormal_tumor_incidence0.94602910
80MP0003453_abnormal_keratinocyte_physiol0.91935964
81MP0002396_abnormal_hematopoietic_system0.88345692
82MP0000609_abnormal_liver_physiology0.87032142
83MP0001851_eye_inflammation0.84533368
84MP0002998_abnormal_bone_remodeling0.83100922
85MP0001873_stomach_inflammation0.82926465
86MP0003693_abnormal_embryo_hatching0.81598033
87MP0005310_abnormal_salivary_gland0.80753972
88MP0005319_abnormal_enzyme/_coenzyme0.79488029
89MP0004381_abnormal_hair_follicle0.76576947
90MP0002653_abnormal_ependyma_morphology0.76457289
91MP0008874_decreased_physiological_sensi0.75424611
92MP0003111_abnormal_nucleus_morphology0.74489704
93MP0004233_abnormal_muscle_weight0.74107932
94MP0001730_embryonic_growth_arrest0.73239828
95MP0003566_abnormal_cell_adhesion0.72200831
96MP0000358_abnormal_cell_content/0.71711114
97MP0000604_amyloidosis0.71316648
98MP0003448_altered_tumor_morphology0.68542249
99MP0003077_abnormal_cell_cycle0.68066128
100MP0004808_abnormal_hematopoietic_stem0.66874062

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.19005368
2Prolonged bleeding time (HP:0003010)4.14821708
3Recurrent abscess formation (HP:0002722)4.07867314
4Purpura (HP:0000979)4.07517668
5Eczematoid dermatitis (HP:0000976)4.05518165
6Recurrent bacterial skin infections (HP:0005406)3.99739645
7Abnormality of cells of the erythroid lineage (HP:0012130)3.84286040
8Petechiae (HP:0000967)3.72177577
9Obstructive lung disease (HP:0006536)3.58200744
10Chronic obstructive pulmonary disease (HP:0006510)3.58200744
11Epistaxis (HP:0000421)3.27212465
12Menorrhagia (HP:0000132)3.26753582
13Elevated erythrocyte sedimentation rate (HP:0003565)3.13052542
14Abnormal number of erythroid precursors (HP:0012131)3.03483879
15Gingival bleeding (HP:0000225)3.00377384
16Abnormal platelet volume (HP:0011876)3.00370575
17Myositis (HP:0100614)2.92242820
18Recurrent gram-negative bacterial infections (HP:0005420)2.87247203
19Pallor (HP:0000980)2.87090796
20Mediastinal lymphadenopathy (HP:0100721)2.87025247
21Encephalitis (HP:0002383)2.77046556
22Urticaria (HP:0001025)2.73316928
23Orchitis (HP:0100796)2.71267421
24Reticulocytopenia (HP:0001896)2.69688905
25Increased IgM level (HP:0003496)2.69647658
26Increased serum ferritin (HP:0003281)2.69105292
27Gastrointestinal infarctions (HP:0005244)2.68703661
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66870462
29Increased intramyocellular lipid droplets (HP:0012240)2.64695745
30Increased mean platelet volume (HP:0011877)2.64683806
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.64472748
32Macrocytic anemia (HP:0001972)2.60971825
33Abnormal platelet function (HP:0011869)2.59528980
34Impaired platelet aggregation (HP:0003540)2.59528980
35Hepatosplenomegaly (HP:0001433)2.55969299
36Increased muscle lipid content (HP:0009058)2.53170569
37Recurrent skin infections (HP:0001581)2.51497932
38Meningitis (HP:0001287)2.47333037
39Renal Fanconi syndrome (HP:0001994)2.45361150
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41899170
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41899170
42Spontaneous hematomas (HP:0007420)2.40555310
43Hypertensive crisis (HP:0100735)2.34724698
44Progressive muscle weakness (HP:0003323)2.31857468
45Optic neuritis (HP:0100653)2.29815867
46Retrobulbar optic neuritis (HP:0100654)2.29815867
47Stomatitis (HP:0010280)2.27732262
48Recurrent fungal infections (HP:0002841)2.25888862
49Thrombocytosis (HP:0001894)2.25296451
50Cellulitis (HP:0100658)2.22469500
51Abnormal hemoglobin (HP:0011902)2.21758025
52Acute hepatic failure (HP:0006554)2.21001844
53Recurrent viral infections (HP:0004429)2.19338605
54Gastrointestinal inflammation (HP:0004386)2.18925135
55Abnormality of reticulocytes (HP:0004312)2.18003283
56Ragged-red muscle fibers (HP:0003200)2.16414014
57Inflammation of the large intestine (HP:0002037)2.12139508
58Respiratory difficulties (HP:0002880)2.10836884
59Increased IgE level (HP:0003212)2.10125960
60Paralysis (HP:0003470)2.09380701
61Abnormality of iron homeostasis (HP:0011031)2.07981089
62Increased hepatocellular lipid droplets (HP:0006565)2.07210730
63Abnormality of liposaccharide metabolism (HP:0010968)2.07147832
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.07147832
65Abnormality of glycolipid metabolism (HP:0010969)2.07147832
66Rough bone trabeculation (HP:0100670)2.06985525
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06896300
68Anorexia (HP:0002039)2.03936402
69Increased cerebral lipofuscin (HP:0011813)2.02091701
70Colitis (HP:0002583)2.01161825
71Hypochromic anemia (HP:0001931)2.00936469
72Abnormal delayed hypersensitivity skin test (HP:0002963)1.99451035
73Episodic fever (HP:0001954)1.97807391
74Arterial thrombosis (HP:0004420)1.95595325
75Recurrent cutaneous fungal infections (HP:0011370)1.95322728
76Chronic mucocutaneous candidiasis (HP:0002728)1.95322728
77Gingivitis (HP:0000230)1.94785614
78Vasculitis (HP:0002633)1.94560050
79Reticulocytosis (HP:0001923)1.93520620
80Vertebral compression fractures (HP:0002953)1.93121113
81Lipid accumulation in hepatocytes (HP:0006561)1.90906214
82Abnormal mitochondria in muscle tissue (HP:0008316)1.90328361
83Deep venous thrombosis (HP:0002625)1.90054625
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88980083
85Microcytic anemia (HP:0001935)1.88839167
86Vacuolated lymphocytes (HP:0001922)1.87543573
87Exertional dyspnea (HP:0002875)1.86631587
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86282105
89Abnormality of the common coagulation pathway (HP:0010990)1.85922455
90Progressive neurologic deterioration (HP:0002344)1.84762314
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83750318
92Amyloidosis (HP:0011034)1.83530960
93Progressive external ophthalmoplegia (HP:0000590)1.83342205
94Polycythemia (HP:0001901)1.83163249
95Keratoconjunctivitis sicca (HP:0001097)1.82290568
96Panhypogammaglobulinemia (HP:0003139)1.82113179
97Chest pain (HP:0100749)1.80007906
98Hyperthyroidism (HP:0000836)1.78375875
99Hypergammaglobulinemia (HP:0010702)1.77946404
100Pustule (HP:0200039)1.77027170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.52361134
2RIPK43.33548310
3NME23.14497463
4STK163.07097584
5MAP3K112.66563807
6PRPF4B2.47234438
7ERN12.38993644
8TRIB32.38068430
9MAP2K32.31725847
10GRK62.05945196
11SMG12.05076069
12MAP4K11.97979078
13IRAK31.93860642
14TESK11.88340305
15BLK1.82164307
16VRK21.72192674
17EIF2AK11.70229523
18IRAK41.70088780
19TAOK21.67614798
20CSK1.58153216
21LRRK21.57015411
22TYK21.52907631
23ZAP701.43435272
24BTK1.41822339
25SCYL21.40818613
26ARAF1.35190370
27SIK11.31280345
28ICK1.23356285
29FES1.18541123
30TAOK11.17200321
31TBK11.16553716
32PIM21.16456704
33BMX1.12279617
34DYRK1B1.08403665
35MAP3K11.01240200
36SYK0.97333300
37MAP3K30.93966071
38KSR20.92947593
39MAP3K60.90771552
40CDK190.87169093
41JAK30.87141442
42IKBKE0.87109325
43FGR0.87029320
44CSF1R0.84442698
45DYRK30.83097761
46MAP3K50.82879120
47FGFR40.82423097
48PAK40.81259727
49MATK0.80897620
50BCKDK0.80730627
51TNK20.78915492
52HCK0.78776344
53LYN0.78159592
54MAP3K120.77422372
55ILK0.75266276
56IRAK20.73363684
57IKBKB0.73007260
58JAK20.71719949
59MAP3K140.71692694
60PDPK10.69764934
61AURKA0.69091552
62MARK20.68292247
63KDR0.68260528
64EPHB10.67545025
65BRAF0.66335763
66ABL20.66008037
67CDK120.64171826
68DAPK30.63291654
69SRPK10.62778385
70PTK60.62300331
71MAP3K100.62131399
72MARK30.60859461
73RPS6KB20.60168287
74ITK0.58619474
75LCK0.58401238
76TLK10.58252131
77PAK10.56651894
78MAP2K40.54545446
79SIK30.54134872
80STK100.53781696
81RPS6KC10.53269299
82RPS6KL10.53269299
83PIM10.53047038
84TXK0.51866737
85LIMK10.50774692
86MAPK110.50767341
87PDK10.49568609
88MAP3K80.47491546
89CDK70.46905398
90RAF10.46692495
91MAP2K20.46243261
92PBK0.46181055
93STK40.45545025
94RET0.43698898
95BMPR20.41864916
96CDK40.39484595
97SIK20.38010092
98NME10.37443127
99PRKCD0.36617083
100PKN20.35143778

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.42399370
2Other glycan degradation_Homo sapiens_hsa005111.93443913
3Oxidative phosphorylation_Homo sapiens_hsa001901.92450900
4B cell receptor signaling pathway_Homo sapiens_hsa046621.85376357
5Proteasome_Homo sapiens_hsa030501.79536685
6Osteoclast differentiation_Homo sapiens_hsa043801.79387218
7Leishmaniasis_Homo sapiens_hsa051401.79057920
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78922250
9Parkinsons disease_Homo sapiens_hsa050121.72080225
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70211442
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68347401
12DNA replication_Homo sapiens_hsa030301.66567845
13Acute myeloid leukemia_Homo sapiens_hsa052211.65466455
14Sulfur relay system_Homo sapiens_hsa041221.63557337
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59359620
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59291234
17Shigellosis_Homo sapiens_hsa051311.54057979
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53306951
19Primary immunodeficiency_Homo sapiens_hsa053401.50153739
20Non-small cell lung cancer_Homo sapiens_hsa052231.47147737
21Spliceosome_Homo sapiens_hsa030401.41536347
22Staphylococcus aureus infection_Homo sapiens_hsa051501.38434900
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38332042
24Pancreatic cancer_Homo sapiens_hsa052121.34876289
25Pentose phosphate pathway_Homo sapiens_hsa000301.34259515
26Tuberculosis_Homo sapiens_hsa051521.31986296
27Measles_Homo sapiens_hsa051621.25162591
28Apoptosis_Homo sapiens_hsa042101.23888425
29Allograft rejection_Homo sapiens_hsa053301.20659839
30Hematopoietic cell lineage_Homo sapiens_hsa046401.20359628
31T cell receptor signaling pathway_Homo sapiens_hsa046601.20273016
32Chronic myeloid leukemia_Homo sapiens_hsa052201.17998147
33Chemokine signaling pathway_Homo sapiens_hsa040621.17351185
34Herpes simplex infection_Homo sapiens_hsa051681.16934794
35Malaria_Homo sapiens_hsa051441.15252875
36Huntingtons disease_Homo sapiens_hsa050161.15079956
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15038047
38Lysosome_Homo sapiens_hsa041421.15016550
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14943134
40Hepatitis B_Homo sapiens_hsa051611.12179836
41Viral carcinogenesis_Homo sapiens_hsa052031.11655644
42Pyrimidine metabolism_Homo sapiens_hsa002401.11294531
43Autoimmune thyroid disease_Homo sapiens_hsa053201.10788379
44Base excision repair_Homo sapiens_hsa034101.10717841
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10685255
46Epstein-Barr virus infection_Homo sapiens_hsa051691.10539381
47Phagosome_Homo sapiens_hsa041451.10088219
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.09702766
49Graft-versus-host disease_Homo sapiens_hsa053321.09592230
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08756088
51Salmonella infection_Homo sapiens_hsa051321.08359346
52Alzheimers disease_Homo sapiens_hsa050101.08173226
53Endocytosis_Homo sapiens_hsa041441.06441402
54Galactose metabolism_Homo sapiens_hsa000521.03373103
55Platelet activation_Homo sapiens_hsa046111.02498286
56Mismatch repair_Homo sapiens_hsa034301.01492242
57Collecting duct acid secretion_Homo sapiens_hsa049661.01484610
58Notch signaling pathway_Homo sapiens_hsa043301.01432800
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00264888
60Systemic lupus erythematosus_Homo sapiens_hsa053220.98187705
61Vibrio cholerae infection_Homo sapiens_hsa051100.97514267
62RNA polymerase_Homo sapiens_hsa030200.96194112
63Renal cell carcinoma_Homo sapiens_hsa052110.96138908
64VEGF signaling pathway_Homo sapiens_hsa043700.95632741
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94645748
66Nucleotide excision repair_Homo sapiens_hsa034200.94222205
67Influenza A_Homo sapiens_hsa051640.94111825
68Antigen processing and presentation_Homo sapiens_hsa046120.93969669
69Bladder cancer_Homo sapiens_hsa052190.91465911
70Hepatitis C_Homo sapiens_hsa051600.89143701
71Thyroid cancer_Homo sapiens_hsa052160.86346300
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84287564
73Viral myocarditis_Homo sapiens_hsa054160.83402215
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83323468
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81532333
76Legionellosis_Homo sapiens_hsa051340.78101993
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.75390932
78Rheumatoid arthritis_Homo sapiens_hsa053230.74727813
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.74375567
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73207100
81Biosynthesis of amino acids_Homo sapiens_hsa012300.64880739
82Toxoplasmosis_Homo sapiens_hsa051450.64146364
83Endometrial cancer_Homo sapiens_hsa052130.63565586
84Asthma_Homo sapiens_hsa053100.63302844
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61026529
86TNF signaling pathway_Homo sapiens_hsa046680.60103210
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.59929934
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56191346
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54329954
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.54067283
91HTLV-I infection_Homo sapiens_hsa051660.50497688
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.50293430
93Carbon metabolism_Homo sapiens_hsa012000.48150900
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47178558
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.46319140
96Pertussis_Homo sapiens_hsa051330.46214837
97Insulin signaling pathway_Homo sapiens_hsa049100.45734128
98Alcoholism_Homo sapiens_hsa050340.44867875
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.44460185
100Prion diseases_Homo sapiens_hsa050200.40950447

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