SUPT5H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.87459516
2Golgi transport vesicle coating (GO:0048200)4.87459516
3negative regulation of erythrocyte differentiation (GO:0045647)4.51433183
4regulation of glucose import in response to insulin stimulus (GO:2001273)4.03310236
5protein localization to endosome (GO:0036010)3.93361773
6spliceosomal tri-snRNP complex assembly (GO:0000244)3.88937306
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.88350903
8regulation of NFAT protein import into nucleus (GO:0051532)3.73646195
9activation of Rac GTPase activity (GO:0032863)3.69439297
10mannose metabolic process (GO:0006013)3.65663458
11adherens junction assembly (GO:0034333)3.63293091
12negative regulation of cell size (GO:0045792)3.55731870
13focal adhesion assembly (GO:0048041)3.48539911
14cell-substrate adherens junction assembly (GO:0007045)3.48539911
15regulation of early endosome to late endosome transport (GO:2000641)3.45891486
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.44011613
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43286191
18negative regulation of fatty acid transport (GO:2000192)3.42517273
19protein retention in ER lumen (GO:0006621)3.42459443
20activation of MAPKKK activity (GO:0000185)3.37151126
213-UTR-mediated mRNA stabilization (GO:0070935)3.21023958
22regulation of nucleobase-containing compound transport (GO:0032239)3.20762919
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.17521161
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.15821107
25apoptotic process involved in morphogenesis (GO:0060561)3.12944341
26stress fiber assembly (GO:0043149)3.08079609
27semaphorin-plexin signaling pathway (GO:0071526)3.05334176
28modulation by symbiont of host cellular process (GO:0044068)3.04142603
29positive regulation of nuclease activity (GO:0032075)3.03691269
30regulation of histone H3-K27 methylation (GO:0061085)3.01037604
31intracellular estrogen receptor signaling pathway (GO:0030520)2.98237868
32cell-substrate junction assembly (GO:0007044)2.97146636
33regulation of RNA export from nucleus (GO:0046831)2.94543922
34NIK/NF-kappaB signaling (GO:0038061)2.93698707
35barbed-end actin filament capping (GO:0051016)2.90921639
36planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90266738
37mRNA stabilization (GO:0048255)2.85431294
38RNA stabilization (GO:0043489)2.85431294
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85282103
40response to laminar fluid shear stress (GO:0034616)2.83053031
41embryonic process involved in female pregnancy (GO:0060136)2.80800812
42modulation by virus of host process (GO:0019054)2.77896022
43regulation of nuclease activity (GO:0032069)2.74138522
44endoplasmic reticulum unfolded protein response (GO:0030968)2.73894848
45regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72387086
46maternal placenta development (GO:0001893)2.71651030
47proline biosynthetic process (GO:0006561)2.70255256
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68874283
49regulation of chromatin binding (GO:0035561)2.68574362
50glucocorticoid receptor signaling pathway (GO:0042921)2.68573980
51regulation of ARF protein signal transduction (GO:0032012)2.67502414
52signal complex assembly (GO:0007172)2.64540398
53epithelial cell-cell adhesion (GO:0090136)2.62416936
54ER-nucleus signaling pathway (GO:0006984)2.62309341
55positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61993591
56skin morphogenesis (GO:0043589)2.61138226
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.58530991
58response to muramyl dipeptide (GO:0032495)2.58094428
59basement membrane organization (GO:0071711)2.57549199
60regulation of ARF GTPase activity (GO:0032312)2.56916582
61pentose-phosphate shunt (GO:0006098)2.56913795
62mitotic chromosome condensation (GO:0007076)2.56563332
63positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55949478
64cellular response to virus (GO:0098586)2.55231941
65activation of JUN kinase activity (GO:0007257)2.53894139
66histone H2B ubiquitination (GO:0033523)2.51018825
67retrograde transport, endosome to Golgi (GO:0042147)2.50898741
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50452041
69glucose 6-phosphate metabolic process (GO:0051156)2.49899418
70cellular response to unfolded protein (GO:0034620)2.49479923
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48208824
72negative regulation of viral release from host cell (GO:1902187)2.48084056
73cellular response to epidermal growth factor stimulus (GO:0071364)2.46338501
74thymic T cell selection (GO:0045061)2.46308702
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.45546309
76histone H3-K36 demethylation (GO:0070544)2.44537064
77regulation of translational fidelity (GO:0006450)2.43749384
78regulation of extracellular matrix disassembly (GO:0010715)2.42904979
79cell-cell junction maintenance (GO:0045217)2.41868028
80histone H4 deacetylation (GO:0070933)2.41021421
81positive regulation of protein dephosphorylation (GO:0035307)2.40611947
82cellular protein complex localization (GO:0034629)2.39840659
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39705778
84endothelial cell chemotaxis (GO:0035767)2.39566269
85modulation by virus of host morphology or physiology (GO:0019048)2.39192910
86positive regulation of extracellular matrix organization (GO:1903055)2.38901970
87negative regulation of myotube differentiation (GO:0010832)2.37495235
88positive regulation of histone deacetylation (GO:0031065)2.36868370
89regulation of cholesterol homeostasis (GO:2000188)2.36776144
90regulation of fatty acid beta-oxidation (GO:0031998)2.35967050
91regulation of defense response to virus by virus (GO:0050690)2.33684232
92snRNA metabolic process (GO:0016073)2.33097107
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.30904782
94pinocytosis (GO:0006907)2.29547991
95cellular response to topologically incorrect protein (GO:0035967)2.29538848
96actin filament bundle assembly (GO:0051017)2.29347501
97actin filament bundle organization (GO:0061572)2.29347501
98vesicle coating (GO:0006901)2.28583238
99protein export from nucleus (GO:0006611)2.26492195
100protein targeting to plasma membrane (GO:0072661)2.26475615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.03988039
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84639344
3VDR_21846776_ChIP-Seq_THP-1_Human2.78745765
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.78322125
5LXR_22292898_ChIP-Seq_THP-1_Human2.60506645
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55958220
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.51232132
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.50512941
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43141902
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38583142
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26700931
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18848035
13TCF7_22412390_ChIP-Seq_EML_Mouse2.16600142
14KDM2B_26808549_Chip-Seq_DND41_Human2.13467045
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12738266
16RACK7_27058665_Chip-Seq_MCF-7_Human2.10241229
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10121531
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06572411
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85186088
20KDM2B_26808549_Chip-Seq_K562_Human1.77886329
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71100613
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70660762
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70333658
24ZNF263_19887448_ChIP-Seq_K562_Human1.70217205
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69621630
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67591035
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66457833
28CLOCK_20551151_ChIP-Seq_293T_Human1.55646232
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55318384
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52577878
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51976891
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.51461035
33* TET1_21451524_ChIP-Seq_MESCs_Mouse1.50403108
34MAF_26560356_Chip-Seq_TH1_Human1.50314504
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49924299
36P68_20966046_ChIP-Seq_HELA_Human1.48789144
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48431597
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48268945
39* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.47304885
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.47162071
41VDR_24763502_ChIP-Seq_THP-1_Human1.46862778
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46695934
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46564855
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45111726
45* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45064670
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42175616
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39854272
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.38352443
49* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36463529
50CREB1_26743006_Chip-Seq_LNCaP_Human1.35562715
51SMC4_20622854_ChIP-Seq_HELA_Human1.35270540
52MAF_26560356_Chip-Seq_TH2_Human1.34028148
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33191266
54UTX_26944678_Chip-Seq_JUKART_Human1.32670207
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31734852
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.31074963
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28853608
58NCOR1_26117541_ChIP-Seq_K562_Human1.26819152
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25842972
60ATF3_27146783_Chip-Seq_COLON_Human1.25544450
61E2F7_22180533_ChIP-Seq_HELA_Human1.25415629
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22893115
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22616024
64* RUNX1_22412390_ChIP-Seq_EML_Mouse1.21987324
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.21123268
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20820078
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18463617
68TP53_22127205_ChIP-Seq_IMR90_Human1.18206549
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17978043
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16132773
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16005973
72* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12320555
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.11933026
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10719533
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08891116
76* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07936613
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07588580
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07276420
79* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05750978
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.05193233
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04946671
82* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03351443
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03035005
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02877385
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01993811
86XRN2_22483619_ChIP-Seq_HELA_Human1.00743601
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00660342
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00607050
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.99721531
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98848052
91BCOR_27268052_Chip-Seq_Bcells_Human0.98291774
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98112075
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97274390
94UBF1/2_26484160_Chip-Seq_HMECs_Human0.96703025
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96284733
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96240331
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96134178
98CIITA_25753668_ChIP-Seq_RAJI_Human0.93715784
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93317531
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92126967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.00864482
2MP0005451_abnormal_body_composition3.20363799
3MP0005076_abnormal_cell_differentiation2.98058156
4MP0005058_abnormal_lysosome_morphology2.88381735
5MP0004185_abnormal_adipocyte_glucose2.86886330
6MP0002877_abnormal_melanocyte_morpholog2.70556888
7MP0003566_abnormal_cell_adhesion2.61559745
8MP0008260_abnormal_autophagy2.44064119
9MP0001849_ear_inflammation2.26503874
10MP0004858_abnormal_nervous_system2.21365132
11MP0003300_gastrointestinal_ulcer2.16385473
12MP0001348_abnormal_lacrimal_gland2.11893831
13MP0003172_abnormal_lysosome_physiology2.10971461
14MP0003091_abnormal_cell_migration2.09012775
15MP0005409_darkened_coat_color2.06995782
16MP0008438_abnormal_cutaneous_collagen2.02387680
17MP0003436_decreased_susceptibility_to2.00901667
18MP0003453_abnormal_keratinocyte_physiol1.99800287
19MP0009278_abnormal_bone_marrow1.99178316
20MP0004233_abnormal_muscle_weight1.96947952
21MP0003303_peritoneal_inflammation1.95816755
22MP0009840_abnormal_foam_cell1.90715771
23MP0010234_abnormal_vibrissa_follicle1.82994203
24MP0005666_abnormal_adipose_tissue1.73932648
25MP0000537_abnormal_urethra_morphology1.66873823
26MP0000858_altered_metastatic_potential1.61363241
27MP0004947_skin_inflammation1.60788830
28MP0005623_abnormal_meninges_morphology1.56466869
29MP0000678_abnormal_parathyroid_gland1.53227753
30MP0001730_embryonic_growth_arrest1.50385845
31MP0003763_abnormal_thymus_physiology1.50248188
32MP0003329_amyloid_beta_deposits1.49734768
33MP0005375_adipose_tissue_phenotype1.46405452
34MP0000733_abnormal_muscle_development1.46108801
35MP0002089_abnormal_postnatal_growth/wei1.38449224
36MP0005257_abnormal_intraocular_pressure1.37433095
37MP0000003_abnormal_adipose_tissue1.34743295
38MP0002796_impaired_skin_barrier1.31936353
39MP0010352_gastrointestinal_tract_polyps1.29159701
40MP0002396_abnormal_hematopoietic_system1.28254207
41MP0009333_abnormal_splenocyte_physiolog1.27462233
42MP0004808_abnormal_hematopoietic_stem1.27003163
43MP0005621_abnormal_cell_physiology1.26910235
44MP0003191_abnormal_cellular_cholesterol1.26429811
45MP0005501_abnormal_skin_physiology1.25875135
46MP0002060_abnormal_skin_morphology1.23314311
47MP0005023_abnormal_wound_healing1.17438139
48MP0003111_abnormal_nucleus_morphology1.12615627
49MP0000747_muscle_weakness1.11964426
50MP0002249_abnormal_larynx_morphology1.10205026
51MP0001873_stomach_inflammation1.09450673
52MP0003279_aneurysm1.06798267
53MP0000350_abnormal_cell_proliferation1.04863933
54MP0000751_myopathy1.03571130
55MP0009672_abnormal_birth_weight1.00951192
56MP0001958_emphysema0.97735487
57MP0004264_abnormal_extraembryonic_tissu0.97199368
58MP0004272_abnormal_basement_membrane0.94422232
59MP0004510_myositis0.94394618
60MP0000685_abnormal_immune_system0.92126509
61MP0002998_abnormal_bone_remodeling0.91940157
62MP0002080_prenatal_lethality0.91696051
63MP0001915_intracranial_hemorrhage0.90001953
64MP0000759_abnormal_skeletal_muscle0.88080319
65MP0000767_abnormal_smooth_muscle0.87472210
66MP0010630_abnormal_cardiac_muscle0.86981580
67MP0000490_abnormal_crypts_of0.86582277
68MP0001216_abnormal_epidermal_layer0.85631792
69MP0000703_abnormal_thymus_morphology0.85085797
70MP0005384_cellular_phenotype0.84289587
71MP0001853_heart_inflammation0.83410093
72MP0003634_abnormal_glial_cell0.83158074
73MP0004859_abnormal_synaptic_plasticity0.82850443
74MP0001727_abnormal_embryo_implantation0.81712771
75MP0009931_abnormal_skin_appearance0.80495825
76MP0000604_amyloidosis0.79333471
77MP0002086_abnormal_extraembryonic_tissu0.78019178
78MP0010307_abnormal_tumor_latency0.77535058
79MP0002398_abnormal_bone_marrow0.77243006
80MP0004087_abnormal_muscle_fiber0.75714050
81MP0003115_abnormal_respiratory_system0.75425987
82MP0001545_abnormal_hematopoietic_system0.73578375
83MP0005397_hematopoietic_system_phenotyp0.73578375
84MP0000313_abnormal_cell_death0.72687770
85MP0002970_abnormal_white_adipose0.71917848
86MP0002009_preneoplasia0.71784879
87MP0003984_embryonic_growth_retardation0.70906089
88MP0005000_abnormal_immune_tolerance0.70477067
89MP0000467_abnormal_esophagus_morphology0.69887960
90MP0003075_altered_response_to0.68803501
91MP0001672_abnormal_embryogenesis/_devel0.67131594
92MP0005380_embryogenesis_phenotype0.67131594
93MP0003045_fibrosis0.65758242
94MP0000681_abnormal_thyroid_gland0.64035005
95MP0001533_abnormal_skeleton_physiology0.63570373
96MP0006138_congestive_heart_failure0.63567274
97MP0005464_abnormal_platelet_physiology0.63297168
98MP0002429_abnormal_blood_cell0.63269523
99MP0002088_abnormal_embryonic_growth/wei0.62824493
100MP0009053_abnormal_anal_canal0.61843772

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.76294682
2Obstructive sleep apnea (HP:0002870)3.26387161
3Protrusio acetabuli (HP:0003179)3.05566449
4Broad face (HP:0000283)3.02616881
5Premature rupture of membranes (HP:0001788)2.95860083
6Distal lower limb amyotrophy (HP:0008944)2.91520343
7Upper limb amyotrophy (HP:0009129)2.75836836
8Distal upper limb amyotrophy (HP:0007149)2.75836836
9Achilles tendon contracture (HP:0001771)2.72726052
10Vertebral compression fractures (HP:0002953)2.65876040
11Long palpebral fissure (HP:0000637)2.60735060
12Cerebral aneurysm (HP:0004944)2.59084957
13Increased connective tissue (HP:0009025)2.56105786
14Ulnar bowing (HP:0003031)2.54779302
15Abnormality of the Achilles tendon (HP:0005109)2.46702663
16Insomnia (HP:0100785)2.46440821
17Centrally nucleated skeletal muscle fibers (HP:0003687)2.30336375
18Cerebral inclusion bodies (HP:0100314)2.26401214
19Shallow orbits (HP:0000586)2.21976427
20Disproportionate tall stature (HP:0001519)2.21879284
21Lower limb amyotrophy (HP:0007210)2.21463774
22Abnormality of the fingertips (HP:0001211)2.20774758
23Flat acetabular roof (HP:0003180)2.20273913
24Thin bony cortex (HP:0002753)2.16971457
25Hand muscle atrophy (HP:0009130)2.15188069
26Mitral regurgitation (HP:0001653)2.11660841
27Difficulty climbing stairs (HP:0003551)2.11399056
28Neonatal hypoglycemia (HP:0001998)2.09634853
29Cervical subluxation (HP:0003308)2.08805228
30Dysmetric saccades (HP:0000641)2.07686246
31Cellulitis (HP:0100658)2.04880496
32Trismus (HP:0000211)2.01755904
33Abnormal gallbladder physiology (HP:0012438)2.00379962
34Cholecystitis (HP:0001082)2.00379962
35Pointed chin (HP:0000307)1.99333986
36Abnormality of the thoracic spine (HP:0100711)1.96790096
37Short nail (HP:0001799)1.96265507
38Distal lower limb muscle weakness (HP:0009053)1.96165900
39Supranuclear gaze palsy (HP:0000605)1.94775312
40Hemorrhage of the eye (HP:0011885)1.93119462
41Fragile skin (HP:0001030)1.92833212
42Biconcave vertebral bodies (HP:0004586)1.91900347
43Genu recurvatum (HP:0002816)1.91148757
44Deep palmar crease (HP:0006191)1.89857252
45Abnormality of the distal phalanges of the toes (HP:0010182)1.89758752
46Segmental peripheral demyelination/remyelination (HP:0003481)1.88016894
47Neurofibrillary tangles (HP:0002185)1.87951316
48J-shaped sella turcica (HP:0002680)1.87541047
49Interstitial pulmonary disease (HP:0006530)1.86568303
50Atrophic scars (HP:0001075)1.86265638
51Hyperparathyroidism (HP:0000843)1.84110533
52Bladder diverticulum (HP:0000015)1.83271465
53Dysostosis multiplex (HP:0000943)1.82053259
54Neuronal loss in central nervous system (HP:0002529)1.81786640
55Patellar dislocation (HP:0002999)1.80634465
56Aneurysm (HP:0002617)1.79401877
57Sparse lateral eyebrow (HP:0005338)1.79026347
58Dislocated radial head (HP:0003083)1.78780131
59Spinal rigidity (HP:0003306)1.77458289
60Back pain (HP:0003418)1.77126923
61Peripheral hypomyelination (HP:0007182)1.76610822
62Stridor (HP:0010307)1.76104027
63Hammertoe (HP:0001765)1.75290915
64Emphysema (HP:0002097)1.75067283
65Nuclear cataract (HP:0100018)1.74713105
66Increased variability in muscle fiber diameter (HP:0003557)1.74576994
67Thoracic kyphosis (HP:0002942)1.74240221
68Mitral valve prolapse (HP:0001634)1.73917485
69Wormian bones (HP:0002645)1.72964972
70Mildly elevated creatine phosphokinase (HP:0008180)1.72653177
71Blue sclerae (HP:0000592)1.71669621
72Turricephaly (HP:0000262)1.70760019
73Atelectasis (HP:0100750)1.70586298
74Advanced eruption of teeth (HP:0006288)1.70478885
75Polygenic inheritance (HP:0010982)1.70349429
76Thin ribs (HP:0000883)1.70310021
77Asymmetry of the thorax (HP:0001555)1.69986104
78Broad distal phalanx of finger (HP:0009836)1.69128134
79Vertebral arch anomaly (HP:0008438)1.68640613
80Gastrointestinal stroma tumor (HP:0100723)1.67057124
81Dilatation of the ascending aorta (HP:0005111)1.66821742
82Abnormality of the radial head (HP:0003995)1.66480989
83Ankyloglossia (HP:0010296)1.66298965
84Abnormality of oral frenula (HP:0000190)1.66056556
85Natal tooth (HP:0000695)1.65580229
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.65486495
87Hypercortisolism (HP:0001578)1.63152521
88Hypertensive crisis (HP:0100735)1.63125890
89Onion bulb formation (HP:0003383)1.62818988
90Easy fatigability (HP:0003388)1.62708972
91Flattened epiphyses (HP:0003071)1.62165973
92Syringomyelia (HP:0003396)1.61682243
93Spinal cord lesions (HP:0100561)1.61682243
94Slow saccadic eye movements (HP:0000514)1.61553677
95Decreased motor nerve conduction velocity (HP:0003431)1.60774197
96Distal sensory impairment (HP:0002936)1.60118276
97Abnormality of skeletal muscle fiber size (HP:0012084)1.59580833
98Bronchomalacia (HP:0002780)1.59281617
99Colitis (HP:0002583)1.57471134
100Reticulocytosis (HP:0001923)1.57232727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.68924650
2CDK123.41903588
3PRPF4B3.28722433
4SMG13.22564963
5ICK2.86988855
6ERN12.81117663
7EEF2K2.77473137
8SIK12.76582154
9IRAK32.55608809
10RIPK11.95309573
11FGFR41.77890852
12SIK21.72065772
13EPHA21.71721182
14MAP3K101.64991093
15NME21.58564634
16PDGFRA1.42561491
17TTN1.32875594
18MAP3K131.30238150
19PAK41.24547490
20PKN21.19339006
21MAP4K11.19209242
22MTOR1.18027106
23MAP3K31.15449017
24LATS21.15257948
25TAOK21.13346713
26MARK21.12451148
27TESK11.11823433
28MAP2K31.07992805
29SIK31.07817677
30EPHB11.07540761
31PRKD31.02328907
32BRD40.98982074
33CDC42BPA0.98719623
34KSR20.97438329
35PRKD20.96963282
36NTRK10.94312634
37ARAF0.93986372
38MST1R0.90573594
39MAP3K140.89711804
40TBK10.89423203
41PTK20.88474332
42PDPK10.85837916
43ILK0.85108881
44TESK20.84871139
45RIPK40.83870951
46MAP3K10.82988966
47MAP3K110.79813207
48PTK60.76282962
49TAOK10.75699726
50CDK40.72562028
51BMX0.71916996
52LMTK20.71621909
53RPS6KA20.71558516
54CAMK1D0.70346417
55IRAK20.67071758
56MAPK110.65857760
57MAP3K80.65104430
58TYRO30.65033951
59TYK20.64835591
60CAMKK10.63176311
61MAP3K90.62368116
62MAP2K20.59375044
63RET0.58135506
64MAP3K20.58122036
65IRAK40.57841429
66LRRK20.57633787
67CAMK1G0.57453519
68HIPK20.56864948
69SCYL20.55939492
70RPS6KC10.55716678
71RPS6KL10.55716678
72DDR20.55613948
73JAK30.55610532
74PDK10.54195752
75MOS0.54130080
76RPS6KB20.52711318
77MAP3K70.52115314
78CDK70.48396407
79STK380.46836512
80BRAF0.45600182
81CDK60.44347632
82PAK20.43522304
83ZAP700.42584808
84TNK20.42375669
85MET0.41936261
86PIM20.41301935
87DYRK1B0.39866709
88PDGFRB0.39826427
89MAP3K60.39405463
90FGFR30.38226152
91ALK0.37831292
92MAPK100.35646462
93CHEK10.32542318
94MAPK120.32367725
95CDK11A0.32059032
96RPS6KA60.32049325
97JAK10.30783396
98PAK60.30449104
99CHUK0.29925098
100MELK0.28731073

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.51624394
2Chronic myeloid leukemia_Homo sapiens_hsa052202.24457366
3Acute myeloid leukemia_Homo sapiens_hsa052212.10306175
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01277713
5Non-small cell lung cancer_Homo sapiens_hsa052231.82909584
6VEGF signaling pathway_Homo sapiens_hsa043701.80689283
7B cell receptor signaling pathway_Homo sapiens_hsa046621.74195438
8Notch signaling pathway_Homo sapiens_hsa043301.73839618
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.71972840
10Pancreatic cancer_Homo sapiens_hsa052121.66283500
11Bladder cancer_Homo sapiens_hsa052191.53580475
12Endometrial cancer_Homo sapiens_hsa052131.52907240
13Renal cell carcinoma_Homo sapiens_hsa052111.52177831
14Neurotrophin signaling pathway_Homo sapiens_hsa047221.49049906
15Prion diseases_Homo sapiens_hsa050201.46937264
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43943860
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41975902
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41570593
19Glioma_Homo sapiens_hsa052141.40450657
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38148716
21ErbB signaling pathway_Homo sapiens_hsa040121.37362332
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35499426
23mTOR signaling pathway_Homo sapiens_hsa041501.34897972
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29000165
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28822921
26Pentose phosphate pathway_Homo sapiens_hsa000301.22529893
27Thyroid cancer_Homo sapiens_hsa052161.19598654
28Insulin signaling pathway_Homo sapiens_hsa049101.19502650
29Fructose and mannose metabolism_Homo sapiens_hsa000511.17124888
30Small cell lung cancer_Homo sapiens_hsa052221.16003642
31Hepatitis B_Homo sapiens_hsa051611.14403567
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11977967
33Osteoclast differentiation_Homo sapiens_hsa043801.10574556
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10077211
35Hepatitis C_Homo sapiens_hsa051601.08569727
36Apoptosis_Homo sapiens_hsa042101.08079493
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07977657
38Focal adhesion_Homo sapiens_hsa045101.07663612
39Prostate cancer_Homo sapiens_hsa052151.06918885
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.06014681
41TNF signaling pathway_Homo sapiens_hsa046681.05237768
42Estrogen signaling pathway_Homo sapiens_hsa049151.05205443
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.04422767
44Colorectal cancer_Homo sapiens_hsa052101.03473250
45Choline metabolism in cancer_Homo sapiens_hsa052311.03240032
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.02841242
47T cell receptor signaling pathway_Homo sapiens_hsa046601.02121963
48Prolactin signaling pathway_Homo sapiens_hsa049171.01248327
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99533628
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99041881
51Toxoplasmosis_Homo sapiens_hsa051450.98300381
52AMPK signaling pathway_Homo sapiens_hsa041520.98115157
53GnRH signaling pathway_Homo sapiens_hsa049120.97704546
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97306302
55Shigellosis_Homo sapiens_hsa051310.97275650
56Influenza A_Homo sapiens_hsa051640.97167854
57Proteoglycans in cancer_Homo sapiens_hsa052050.96359483
58MicroRNAs in cancer_Homo sapiens_hsa052060.95333068
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.95022465
60Adherens junction_Homo sapiens_hsa045200.94869930
61Inositol phosphate metabolism_Homo sapiens_hsa005620.91161292
62Endocytosis_Homo sapiens_hsa041440.89908260
63Amoebiasis_Homo sapiens_hsa051460.89591328
64Viral carcinogenesis_Homo sapiens_hsa052030.89553937
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.87130302
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.86599312
67Lysine degradation_Homo sapiens_hsa003100.85270663
68HTLV-I infection_Homo sapiens_hsa051660.83655094
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82784431
70Biosynthesis of amino acids_Homo sapiens_hsa012300.82742920
71Epstein-Barr virus infection_Homo sapiens_hsa051690.82293640
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81002678
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80587955
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.79584931
75HIF-1 signaling pathway_Homo sapiens_hsa040660.78818114
76Galactose metabolism_Homo sapiens_hsa000520.77599027
77Long-term potentiation_Homo sapiens_hsa047200.77347610
78Salmonella infection_Homo sapiens_hsa051320.76709703
79mRNA surveillance pathway_Homo sapiens_hsa030150.75023871
80Lysosome_Homo sapiens_hsa041420.73616202
81Measles_Homo sapiens_hsa051620.72507470
82Insulin resistance_Homo sapiens_hsa049310.72484025
83Herpes simplex infection_Homo sapiens_hsa051680.71712661
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70796197
85Leishmaniasis_Homo sapiens_hsa051400.70589783
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69898954
87Vibrio cholerae infection_Homo sapiens_hsa051100.68889207
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61727185
89Tuberculosis_Homo sapiens_hsa051520.60436402
90Viral myocarditis_Homo sapiens_hsa054160.58441538
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58288572
92MAPK signaling pathway_Homo sapiens_hsa040100.55565104
93FoxO signaling pathway_Homo sapiens_hsa040680.54488814
94Chemokine signaling pathway_Homo sapiens_hsa040620.54084161
95Rap1 signaling pathway_Homo sapiens_hsa040150.51373605
96ECM-receptor interaction_Homo sapiens_hsa045120.47439231
97Glucagon signaling pathway_Homo sapiens_hsa049220.46579250
98Spliceosome_Homo sapiens_hsa030400.46385330
99N-Glycan biosynthesis_Homo sapiens_hsa005100.46279376
100Type II diabetes mellitus_Homo sapiens_hsa049300.45777323

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