ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	4.20690625
2	Golgi transport vesicle coating (GO:0048200)	4.20690625
3	negative regulation of erythrocyte differentiation (GO:0045647)	3.89457465
4	protein localization to endosome (GO:0036010)	3.64109427
5	adherens junction assembly (GO:0034333)	3.58541652
6	focal adhesion assembly (GO:0048041)	3.55246920
7	cell-substrate adherens junction assembly (GO:0007045)	3.55246920
8	mannose metabolic process (GO:0006013)	3.53984247
9	nuclear pore complex assembly (GO:0051292)	3.42642232
10	cell-substrate junction assembly (GO:0007044)	3.32879886
11	regulation of NFAT protein import into nucleus (GO:0051532)	3.31298672
12	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.25495919
13	embryonic process involved in female pregnancy (GO:0060136)	3.10367828
14	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.10142677
15	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.05881431
16	skin morphogenesis (GO:0043589)	3.05289195
17	response to laminar fluid shear stress (GO:0034616)	3.02250646
18	regulation of early endosome to late endosome transport (GO:2000641)	3.01901524
19	histone H3-K36 demethylation (GO:0070544)	2.91536608
20	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.90470067
21	activation of Rac GTPase activity (GO:0032863)	2.86900295
22	stress fiber assembly (GO:0043149)	2.84945859
23	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.83285094
24	negative regulation of fatty acid transport (GO:2000192)	2.79303681
25	negative regulation of cell size (GO:0045792)	2.78755424
26	pinocytosis (GO:0006907)	2.77320076
27	basement membrane organization (GO:0071711)	2.76234970
28	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.71766144
29	3-UTR-mediated mRNA stabilization (GO:0070935)	2.71355648
30	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.69455201
31	modulation by symbiont of host cellular process (GO:0044068)	2.69296983
32	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.69121764
33	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.68019016
34	regulation of cholesterol homeostasis (GO:2000188)	2.64921626
35	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.62238261
36	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.62215158
37	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.61505763
38	regulation of extracellular matrix disassembly (GO:0010715)	2.61075327
39	positive regulation of nuclease activity (GO:0032075)	2.60989614
40	mRNA stabilization (GO:0048255)	2.58843643
41	RNA stabilization (GO:0043489)	2.58843643
42	apoptotic process involved in morphogenesis (GO:0060561)	2.58331410
43	nuclear pore organization (GO:0006999)	2.57870241
44	glucocorticoid receptor signaling pathway (GO:0042921)	2.57362261
45	cellular response to epidermal growth factor stimulus (GO:0071364)	2.57325765
46	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.57272706
47	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.56171101
48	hemidesmosome assembly (GO:0031581)	2.55434997
49	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.55332467
50	positive regulation of extracellular matrix organization (GO:1903055)	2.52647679
51	semaphorin-plexin signaling pathway (GO:0071526)	2.51842158
52	cortical actin cytoskeleton organization (GO:0030866)	2.51194776
53	pore complex assembly (GO:0046931)	2.48824775
54	epithelial cell-cell adhesion (GO:0090136)	2.48358178
55	endoplasmic reticulum unfolded protein response (GO:0030968)	2.47726741
56	protein retention in ER lumen (GO:0006621)	2.46541876
57	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.45721693
58	regulation of type I interferon-mediated signaling pathway (GO:0060338)	2.44199175
59	ER-nucleus signaling pathway (GO:0006984)	2.43957971
60	vesicle coating (GO:0006901)	2.43935304
61	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.43615578
62	response to epidermal growth factor (GO:0070849)	2.43368344
63	mammary gland epithelial cell proliferation (GO:0033598)	2.40309401
64	* regulation of nucleobase-containing compound transport (GO:0032239)	2.37387144
65	regulation of nuclease activity (GO:0032069)	2.36672981
66	cellular response to virus (GO:0098586)	2.35718110
67	mitotic chromosome condensation (GO:0007076)	2.34986785
68	response to muramyl dipeptide (GO:0032495)	2.34967286
69	positive regulation of histone deacetylation (GO:0031065)	2.34855213
70	intracellular estrogen receptor signaling pathway (GO:0030520)	2.34699544
71	maternal placenta development (GO:0001893)	2.33223489
72	COPII vesicle coating (GO:0048208)	2.33222422
73	histone lysine demethylation (GO:0070076)	2.33080561
74	negative regulation of viral release from host cell (GO:1902187)	2.32955970
75	corticosteroid receptor signaling pathway (GO:0031958)	2.30867482
76	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.30586806
77	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.30445021
78	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.29737955
79	barbed-end actin filament capping (GO:0051016)	2.29690533
80	modulation by virus of host process (GO:0019054)	2.28784886
81	embryonic eye morphogenesis (GO:0048048)	2.27016403
82	histone demethylation (GO:0016577)	2.26971810
83	positive regulation of receptor recycling (GO:0001921)	2.26619248
84	endothelial cell chemotaxis (GO:0035767)	2.26478887
85	cellular response to unfolded protein (GO:0034620)	2.26057282
86	cell adhesion mediated by integrin (GO:0033627)	2.25594818
87	hypotonic response (GO:0006971)	2.24950534
88	regulation of ARF protein signal transduction (GO:0032012)	2.24947302
89	desmosome organization (GO:0002934)	2.22982664
90	low-density lipoprotein particle clearance (GO:0034383)	2.21755635
91	protein export from nucleus (GO:0006611)	2.21709275
92	modulation by virus of host morphology or physiology (GO:0019048)	2.21163349
93	regulation of extracellular matrix organization (GO:1903053)	2.20708711
94	germinal center formation (GO:0002467)	2.20279034
95	atrioventricular valve morphogenesis (GO:0003181)	2.18545065
96	embryonic camera-type eye morphogenesis (GO:0048596)	2.18194730
97	positive regulation of keratinocyte differentiation (GO:0045618)	2.18063469
98	regulation of integrin activation (GO:0033623)	2.18006082
99	dosage compensation (GO:0007549)	2.16863047
100	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.14322806

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	3.76923863
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.47098285
3	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.35557051
4	MYC_22102868_ChIP-Seq_BL_Human	3.12309497
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.53595803
6	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.48548442
7	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.38997873
8	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.38928072
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.34553966
10	TCF7_22412390_ChIP-Seq_EML_Mouse	2.33206960
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.20261486
12	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.19131651
13	LXR_22292898_ChIP-Seq_THP-1_Human	2.17459509
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.10468922
15	KDM2B_26808549_Chip-Seq_DND41_Human	2.04652529
16	RACK7_27058665_Chip-Seq_MCF-7_Human	2.02990462
17	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.02508245
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.01098717
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96120732
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.88979558
21	* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.87185997
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.81728020
23	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.81651445
24	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.80817002
25	KDM2B_26808549_Chip-Seq_K562_Human	1.75670619
26	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.75412727
27	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.72278557
28	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.65657603
29	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.65168822
30	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.56917340
31	VDR_24763502_ChIP-Seq_THP-1_Human	1.53791018
32	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.53750170
33	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.53376884
34	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.52222091
35	MAF_26560356_Chip-Seq_TH1_Human	1.51933685
36	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.51620535
37	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.47996990
38	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.47604678
39	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.45097860
40	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.43825946
41	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.42370122
42	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.41152690
43	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.38936866
44	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.34126235
45	NCOR1_26117541_ChIP-Seq_K562_Human	1.33934358
46	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.33358636
47	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.33305749
48	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33010690
49	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.32016893
50	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.31839034
51	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.31786953
52	ATF3_27146783_Chip-Seq_COLON_Human	1.31578719
53	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.31024124
54	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.29373822
55	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.26861682
56	UTX_26944678_Chip-Seq_JUKART_Human	1.26795759
57	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.25372513
58	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25179041
59	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.24792507
60	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.24366746
61	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.24182941
62	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.23950493
63	* ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.23581614
64	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.22186840
65	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.21860165
66	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.18904887
67	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.18633747
68	MAF_26560356_Chip-Seq_TH2_Human	1.17365515
69	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.15558382
70	CREB1_26743006_Chip-Seq_LNCaP_Human	1.14792843
71	* TP53_22127205_ChIP-Seq_IMR90_Human	1.12768525
72	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.11233527
73	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.11051440
74	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.10589014
75	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.10437622
76	SPI1_23127762_ChIP-Seq_K562_Human	1.10413549
77	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.09956406
78	GATA1_19941826_ChIP-Seq_K562_Human	1.09529591
79	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.09519366
80	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.09384889
81	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.09006211
82	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.07807569
83	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.06368602
84	SMC4_20622854_ChIP-Seq_HELA_Human	1.05962078
85	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.04732762
86	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02752809
87	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.01190934
88	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.01075215
89	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.00583845
90	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.00583845
91	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.00212118
92	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.99914016
93	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.99370999
94	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.99014531
95	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.99014531
96	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.98522136
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.98152772
98	P68_20966046_ChIP-Seq_HELA_Human	0.95575702
99	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.95352783
100	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.93837901

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	4.41538957
2	MP0005076_abnormal_cell_differentiation	3.01488700
3	MP0005451_abnormal_body_composition	2.90669745
4	MP0003566_abnormal_cell_adhesion	2.80945564
5	MP0008438_abnormal_cutaneous_collagen	2.77265741
6	MP0002877_abnormal_melanocyte_morpholog	2.76739453
7	MP0005058_abnormal_lysosome_morphology	2.55055860
8	MP0003300_gastrointestinal_ulcer	2.36667386
9	MP0003091_abnormal_cell_migration	2.19855476
10	MP0010352_gastrointestinal_tract_polyps	2.09805336
11	MP0005409_darkened_coat_color	2.03230592
12	MP0009840_abnormal_foam_cell	1.94945073
13	MP0004185_abnormal_adipocyte_glucose	1.93349247
14	MP0010234_abnormal_vibrissa_follicle	1.93156081
15	MP0001849_ear_inflammation	1.90518715
16	MP0005257_abnormal_intraocular_pressure	1.88867445
17	MP0003453_abnormal_keratinocyte_physiol	1.87024910
18	MP0003303_peritoneal_inflammation	1.86526096
19	MP0003172_abnormal_lysosome_physiology	1.86175056
20	MP0004233_abnormal_muscle_weight	1.82389172
21	MP0003436_decreased_susceptibility_to	1.76195707
22	MP0004947_skin_inflammation	1.69200040
23	MP0008260_abnormal_autophagy	1.60661827
24	MP0009278_abnormal_bone_marrow	1.57709968
25	MP0001348_abnormal_lacrimal_gland	1.54778592
26	MP0004858_abnormal_nervous_system	1.53635239
27	MP0003191_abnormal_cellular_cholesterol	1.51980868
28	MP0004264_abnormal_extraembryonic_tissu	1.51739634
29	MP0002396_abnormal_hematopoietic_system	1.49805031
30	MP0004808_abnormal_hematopoietic_stem	1.48519049
31	MP0000858_altered_metastatic_potential	1.47651915
32	MP0005023_abnormal_wound_healing	1.36196616
33	MP0004272_abnormal_basement_membrane	1.34804899
34	MP0002060_abnormal_skin_morphology	1.33770229
35	MP0000733_abnormal_muscle_development	1.33578673
36	MP0002009_preneoplasia	1.32887494
37	MP0002796_impaired_skin_barrier	1.31113314
38	MP0001915_intracranial_hemorrhage	1.28979703
39	MP0003763_abnormal_thymus_physiology	1.27652458
40	MP0001958_emphysema	1.27230201
41	MP0005666_abnormal_adipose_tissue	1.25455006
42	MP0002089_abnormal_postnatal_growth/wei	1.23566144
43	MP0003279_aneurysm	1.19432966
44	MP0001730_embryonic_growth_arrest	1.19138721
45	MP0000003_abnormal_adipose_tissue	1.18747665
46	MP0005375_adipose_tissue_phenotype	1.18364942
47	MP0000767_abnormal_smooth_muscle	1.17609652
48	MP0005621_abnormal_cell_physiology	1.17006889
49	MP0002998_abnormal_bone_remodeling	1.15209994
50	MP0005275_abnormal_skin_tensile	1.12714971
51	MP0000537_abnormal_urethra_morphology	1.10554835
52	MP0000678_abnormal_parathyroid_gland	1.08696501
53	MP0002166_altered_tumor_susceptibility	1.07037922
54	MP0003828_pulmonary_edema	1.05308766
55	MP0010630_abnormal_cardiac_muscle	1.01785737
56	MP0003329_amyloid_beta_deposits	1.01156255
57	MP0005623_abnormal_meninges_morphology	0.98952188
58	MP0002086_abnormal_extraembryonic_tissu	0.97188751
59	MP0001216_abnormal_epidermal_layer	0.94377862
60	MP0010307_abnormal_tumor_latency	0.94162187
61	MP0002896_abnormal_bone_mineralization	0.93954432
62	MP0009672_abnormal_birth_weight	0.93165318
63	MP0004510_myositis	0.92415005
64	MP0005501_abnormal_skin_physiology	0.92103679
65	MP0000747_muscle_weakness	0.91116357
66	MP0003656_abnormal_erythrocyte_physiolo	0.89726741
67	MP0009333_abnormal_splenocyte_physiolog	0.88248353
68	MP0000350_abnormal_cell_proliferation	0.88050587
69	MP0004087_abnormal_muscle_fiber	0.87797302
70	MP0001873_stomach_inflammation	0.87588191
71	MP0003115_abnormal_respiratory_system	0.85459275
72	MP0003984_embryonic_growth_retardation	0.84950344
73	MP0000759_abnormal_skeletal_muscle	0.84803225
74	MP0009931_abnormal_skin_appearance	0.84054770
75	MP0000685_abnormal_immune_system	0.83961042
76	MP0003111_abnormal_nucleus_morphology	0.83948142
77	MP0001533_abnormal_skeleton_physiology	0.83201598
78	MP0000751_myopathy	0.82812829
79	MP0001851_eye_inflammation	0.79977842
80	MP0002088_abnormal_embryonic_growth/wei	0.79435532
81	MP0002080_prenatal_lethality	0.78850995
82	MP0001853_heart_inflammation	0.78654612
83	MP0006138_congestive_heart_failure	0.77704024
84	MP0003045_fibrosis	0.77445287
85	MP0002419_abnormal_innate_immunity	0.75468815
86	MP0002254_reproductive_system_inflammat	0.75252963
87	MP0003448_altered_tumor_morphology	0.75054966
88	MP0001672_abnormal_embryogenesis/_devel	0.74925258
89	MP0005380_embryogenesis_phenotype	0.74925258
90	MP0000703_abnormal_thymus_morphology	0.74167384
91	MP0002925_abnormal_cardiovascular_devel	0.73421817
92	MP0005384_cellular_phenotype	0.72059329
93	MP0002006_tumorigenesis	0.71417456
94	MP0001545_abnormal_hematopoietic_system	0.70421906
95	MP0005397_hematopoietic_system_phenotyp	0.70421906
96	MP0008057_abnormal_DNA_replication	0.69570643
97	MP0004782_abnormal_surfactant_physiolog	0.69547637
98	MP0005464_abnormal_platelet_physiology	0.69368078
99	MP0000627_abnormal_mammary_gland	0.68237568
100	MP0001661_extended_life_span	0.67787925

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	3.43370704
2	Hyperacusis (HP:0010780)	3.28544045
3	Premature rupture of membranes (HP:0001788)	3.07936838
4	Broad face (HP:0000283)	2.97180548
5	Cerebral aneurysm (HP:0004944)	2.64972692
6	Increased connective tissue (HP:0009025)	2.57568782
7	Vertebral compression fractures (HP:0002953)	2.52875712
8	Obstructive sleep apnea (HP:0002870)	2.52492078
9	Distal lower limb amyotrophy (HP:0008944)	2.47106779
10	Flat acetabular roof (HP:0003180)	2.43686479
11	Abnormality of the fingertips (HP:0001211)	2.41948158
12	Disproportionate tall stature (HP:0001519)	2.27819746
13	Ulnar bowing (HP:0003031)	2.25449809
14	Asymmetry of the thorax (HP:0001555)	2.24224054
15	Achilles tendon contracture (HP:0001771)	2.23175973
16	Aneurysm (HP:0002617)	2.20897905
17	Ankyloglossia (HP:0010296)	2.18156401
18	Deep venous thrombosis (HP:0002625)	2.11315674
19	Cervical subluxation (HP:0003308)	2.11096123
20	Dysmetric saccades (HP:0000641)	2.10349748
21	Shallow orbits (HP:0000586)	2.09045244
22	Abnormality of the Achilles tendon (HP:0005109)	2.07255964
23	Thin bony cortex (HP:0002753)	2.06784352
24	Osteolytic defects of the hand bones (HP:0009699)	2.06037323
25	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.06037323
26	Abnormality of oral frenula (HP:0000190)	2.03511437
27	Dilatation of the ascending aorta (HP:0005111)	2.02291602
28	Fragile skin (HP:0001030)	2.01433188
29	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.01063701
30	Sparse lateral eyebrow (HP:0005338)	2.00887588
31	Insomnia (HP:0100785)	2.00308282
32	Dislocated radial head (HP:0003083)	1.98913048
33	Aortic aneurysm (HP:0004942)	1.98796629
34	Arterial tortuosity (HP:0005116)	1.96672664
35	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.95297916
36	Wormian bones (HP:0002645)	1.95147638
37	Persistence of primary teeth (HP:0006335)	1.93876071
38	Advanced eruption of teeth (HP:0006288)	1.92586246
39	Cerebral inclusion bodies (HP:0100314)	1.92075714
40	Syringomyelia (HP:0003396)	1.92066390
41	Spinal cord lesions (HP:0100561)	1.92066390
42	Bladder diverticulum (HP:0000015)	1.89696102
43	Mitral valve prolapse (HP:0001634)	1.88618052
44	Upper limb amyotrophy (HP:0009129)	1.88265485
45	Distal upper limb amyotrophy (HP:0007149)	1.88265485
46	Vascular tortuosity (HP:0004948)	1.87451925
47	Hemorrhage of the eye (HP:0011885)	1.87021347
48	Long eyelashes (HP:0000527)	1.86714034
49	Atrophic scars (HP:0001075)	1.85236127
50	Long palpebral fissure (HP:0000637)	1.84578617
51	Blue sclerae (HP:0000592)	1.82823042
52	Abnormality of the radial head (HP:0003995)	1.82803700
53	Biconcave vertebral bodies (HP:0004586)	1.82140287
54	Mitral regurgitation (HP:0001653)	1.82123551
55	Abnormality of the thoracic spine (HP:0100711)	1.81903485
56	Interstitial pulmonary disease (HP:0006530)	1.80112273
57	Subacute progressive viral hepatitis (HP:0006572)	1.79662201
58	Lower limb amyotrophy (HP:0007210)	1.77757724
59	Dysostosis multiplex (HP:0000943)	1.76164515
60	Short nail (HP:0001799)	1.75280344
61	Spinal rigidity (HP:0003306)	1.74632421
62	Spondylolisthesis (HP:0003302)	1.74335276
63	Myocardial infarction (HP:0001658)	1.71490801
64	Increased variability in muscle fiber diameter (HP:0003557)	1.71322341
65	Patellar dislocation (HP:0002999)	1.70208075
66	Heterotopia (HP:0002282)	1.68829142
67	Macroorchidism (HP:0000053)	1.67306695
68	Distal lower limb muscle weakness (HP:0009053)	1.66767131
69	Segmental peripheral demyelination/remyelination (HP:0003481)	1.66367830
70	Eczematoid dermatitis (HP:0000976)	1.65206588
71	Genu recurvatum (HP:0002816)	1.65101456
72	Cellulitis (HP:0100658)	1.63091051
73	Aortic dissection (HP:0002647)	1.62806927
74	Neurofibrillary tangles (HP:0002185)	1.62120340
75	Natal tooth (HP:0000695)	1.61791631
76	Abnormality of the distal phalanges of the toes (HP:0010182)	1.61308542
77	Premature skin wrinkling (HP:0100678)	1.60690194
78	Joint laxity (HP:0001388)	1.60586324
79	Abnormality of skeletal muscle fiber size (HP:0012084)	1.60397235
80	Back pain (HP:0003418)	1.60007900
81	Abnormal ossification of hand bones (HP:0005921)	1.59541856
82	Slow saccadic eye movements (HP:0000514)	1.58634233
83	Termporal pattern (HP:0011008)	1.55482947
84	Insidious onset (HP:0003587)	1.55482947
85	Vertebral arch anomaly (HP:0008438)	1.54203157
86	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.53824884
87	Narrow palate (HP:0000189)	1.53696824
88	Relative macrocephaly (HP:0004482)	1.52364648
89	Urinary glycosaminoglycan excretion (HP:0003541)	1.51249883
90	Mucopolysacchariduria (HP:0008155)	1.51249883
91	Ankle contracture (HP:0006466)	1.50778446
92	Pointed chin (HP:0000307)	1.50705290
93	Renal duplication (HP:0000075)	1.50302458
94	Increased IgE level (HP:0003212)	1.50278814
95	Arnold-Chiari malformation (HP:0002308)	1.48834571
96	Abnormality of the acetabulum (HP:0003170)	1.47009898
97	Elbow flexion contracture (HP:0002987)	1.46739643
98	Thoracic kyphosis (HP:0002942)	1.46008261
99	Deep philtrum (HP:0002002)	1.44009897
100	Abnormality of carpal bone ossification (HP:0006257)	1.43185540

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK12	4.66742399
2	TRIB3	4.29894787
3	SMG1	3.21901931
4	PRPF4B	3.07478363
5	ICK	3.00979568
6	EEF2K	2.95094860
7	SIK1	2.73084571
8	ERN1	2.54540998
9	FGFR4	2.39607419
10	RIPK1	2.24569416
11	IRAK3	2.21365222
12	PDGFRA	2.02392578
13	TTN	1.90897605
14	MAP3K13	1.59179544
15	MAP3K10	1.53017973
16	CAMK1D	1.50107555
17	BRD4	1.45806083
18	MTOR	1.42446744
19	MAP3K14	1.40007474
20	PKN2	1.38256131
21	LATS2	1.37306071
22	KSR2	1.30909442
23	MAP2K3	1.27435209
24	CDC42BPA	1.22598809
25	EPHB1	1.18702380
26	MST1R	1.17030513
27	CAMK1G	1.15729558
28	SCYL2	1.13912119
29	EPHA2	1.11421355
30	MARK2	1.07833682
31	RIPK4	1.07144443
32	FGFR3	1.03269491
33	TAOK2	0.96027765
34	MAP3K1	0.92401693
35	PRKD2	0.89991955
36	SIK2	0.89844765
37	PTK2	0.89750434
38	PTK6	0.89442763
39	MAP3K3	0.89401599
40	PAK4	0.87713519
41	TAOK1	0.86424228
42	DDR2	0.84498569
43	PDGFRB	0.82843602
44	RPS6KA2	0.81189098
45	HIPK2	0.79754777
46	ZAP70	0.79210154
47	TYRO3	0.78052089
48	NEK9	0.77962393
49	CDK6	0.77476615
50	MAP4K1	0.76958035
51	CDK4	0.76316921
52	RET	0.75737873
53	PAK2	0.75155631
54	MAPK11	0.74433543
55	RPS6KB2	0.71882760
56	JAK1	0.70498927
57	PDPK1	0.69282960
58	CDK7	0.68816799
59	JAK3	0.68739144
60	TYK2	0.67442063
61	TRPM7	0.67288203
62	NME2	0.66277689
63	SGK3	0.65365710
64	NTRK1	0.65250537
65	MAP3K8	0.63511843
66	MAP3K7	0.62743607
67	RPS6KC1	0.61512152
68	RPS6KL1	0.61512152
69	BMX	0.60930038
70	TBK1	0.60685392
71	MET	0.59692566
72	CDK9	0.58363949
73	MAP3K6	0.57965173
74	WNK1	0.55557084
75	SIK3	0.53308203
76	PRKD3	0.53033559
77	STK38	0.52951967
78	MAP3K2	0.52828484
79	MAP3K9	0.52205133
80	AKT3	0.51598958
81	CHUK	0.50883756
82	IRAK4	0.48962909
83	CLK1	0.48732708
84	MELK	0.48478500
85	IRAK2	0.47763105
86	LATS1	0.47062575
87	ARAF	0.44866439
88	MAP2K2	0.43232505
89	MAPK7	0.41159652
90	ALK	0.39861185
91	MAPK10	0.39815250
92	PDK1	0.39060824
93	MOS	0.38890020
94	CSK	0.38381761
95	RPS6KA6	0.37812667
96	LRRK2	0.34950283
97	CHEK1	0.33590096
98	DMPK	0.32255599
99	STK10	0.32250724
100	MAPK12	0.32226302

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	2.43065132
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.26374738
3	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.21245939
4	Acute myeloid leukemia_Homo sapiens_hsa05221	2.06168249
5	Non-small cell lung cancer_Homo sapiens_hsa05223	1.86097035
6	Pancreatic cancer_Homo sapiens_hsa05212	1.71797917
7	Bladder cancer_Homo sapiens_hsa05219	1.69777203
8	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.60634180
9	Endometrial cancer_Homo sapiens_hsa05213	1.56504952
10	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.56144990
11	Renal cell carcinoma_Homo sapiens_hsa05211	1.55931203
12	Thyroid cancer_Homo sapiens_hsa05216	1.54962670
13	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.54596097
14	VEGF signaling pathway_Homo sapiens_hsa04370	1.52240856
15	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.51745183
16	Notch signaling pathway_Homo sapiens_hsa04330	1.49266017
17	Prion diseases_Homo sapiens_hsa05020	1.41722734
18	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.40939830
19	Prostate cancer_Homo sapiens_hsa05215	1.34782866
20	mTOR signaling pathway_Homo sapiens_hsa04150	1.32940345
21	Focal adhesion_Homo sapiens_hsa04510	1.32761585
22	Small cell lung cancer_Homo sapiens_hsa05222	1.32490469
23	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.32273494
24	ErbB signaling pathway_Homo sapiens_hsa04012	1.27468944
25	MicroRNAs in cancer_Homo sapiens_hsa05206	1.26085402
26	Hepatitis B_Homo sapiens_hsa05161	1.23570197
27	Glioma_Homo sapiens_hsa05214	1.23549192
28	Osteoclast differentiation_Homo sapiens_hsa04380	1.23019756
29	Proteoglycans in cancer_Homo sapiens_hsa05205	1.21703789
30	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.21469788
31	Adherens junction_Homo sapiens_hsa04520	1.21333113
32	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.18244559
33	Amoebiasis_Homo sapiens_hsa05146	1.17078341
34	TNF signaling pathway_Homo sapiens_hsa04668	1.15614200
35	Prolactin signaling pathway_Homo sapiens_hsa04917	1.14755119
36	Insulin signaling pathway_Homo sapiens_hsa04910	1.14634092
37	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.13891567
38	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.13739958
39	Hepatitis C_Homo sapiens_hsa05160	1.12480005
40	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.11677700
41	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.06150604
42	Toxoplasmosis_Homo sapiens_hsa05145	1.05498239
43	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.05040752
44	Influenza A_Homo sapiens_hsa05164	1.04336036
45	Estrogen signaling pathway_Homo sapiens_hsa04915	1.03072574
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.02920578
47	Lysine degradation_Homo sapiens_hsa00310	1.01514478
48	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.00153755
49	Apoptosis_Homo sapiens_hsa04210	1.00082177
50	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.99052709
51	GnRH signaling pathway_Homo sapiens_hsa04912	0.98622535
52	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.97051283
53	Colorectal cancer_Homo sapiens_hsa05210	0.96034661
54	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.95113594
55	Insulin resistance_Homo sapiens_hsa04931	0.94855891
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.93923381
57	Choline metabolism in cancer_Homo sapiens_hsa05231	0.93898358
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.93168304
59	Measles_Homo sapiens_hsa05162	0.93066421
60	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.92227790
61	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.90289435
62	ECM-receptor interaction_Homo sapiens_hsa04512	0.89668691
63	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.87991493
64	Viral carcinogenesis_Homo sapiens_hsa05203	0.86924325
65	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.85288808
66	Leishmaniasis_Homo sapiens_hsa05140	0.85166901
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.84385952
68	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.82134970
69	AMPK signaling pathway_Homo sapiens_hsa04152	0.81310857
70	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.81074968
71	Lysosome_Homo sapiens_hsa04142	0.80615876
72	Shigellosis_Homo sapiens_hsa05131	0.77052112
73	HTLV-I infection_Homo sapiens_hsa05166	0.76536809
74	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.76402690
75	FoxO signaling pathway_Homo sapiens_hsa04068	0.72540762
76	Herpes simplex infection_Homo sapiens_hsa05168	0.72163642
77	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.71426246
78	Endocytosis_Homo sapiens_hsa04144	0.70580669
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.68788538
80	Salmonella infection_Homo sapiens_hsa05132	0.67087980
81	Type II diabetes mellitus_Homo sapiens_hsa04930	0.66343201
82	Platelet activation_Homo sapiens_hsa04611	0.66015033
83	Malaria_Homo sapiens_hsa05144	0.64070555
84	Pathways in cancer_Homo sapiens_hsa05200	0.63465595
85	Long-term potentiation_Homo sapiens_hsa04720	0.63435833
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.63092684
87	Tuberculosis_Homo sapiens_hsa05152	0.62493896
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61860030
89	Chemokine signaling pathway_Homo sapiens_hsa04062	0.55553625
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55146998
91	MAPK signaling pathway_Homo sapiens_hsa04010	0.52865449
92	Galactose metabolism_Homo sapiens_hsa00052	0.52096810
93	Melanoma_Homo sapiens_hsa05218	0.51003702
94	Pertussis_Homo sapiens_hsa05133	0.50860359
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50585685
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.48982092
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.48070126
98	Complement and coagulation cascades_Homo sapiens_hsa04610	0.47605079
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.47580682
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43607508

SUPT6H

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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