SUPT7L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.90228418
2neuronal action potential propagation (GO:0019227)5.61691479
3regulation of cilium movement (GO:0003352)4.87312088
4synapsis (GO:0007129)4.44587845
5kinetochore assembly (GO:0051382)4.22943987
6regulation of microtubule-based movement (GO:0060632)4.20709719
7proline metabolic process (GO:0006560)4.18891244
8axoneme assembly (GO:0035082)4.18544532
9energy homeostasis (GO:0097009)4.09120673
10superoxide anion generation (GO:0042554)4.05343278
11regulation of clathrin-mediated endocytosis (GO:2000369)4.03836452
12interkinetic nuclear migration (GO:0022027)3.81360675
13kinetochore organization (GO:0051383)3.74506136
14regulation of histone H3-K27 methylation (GO:0061085)3.74197935
15rRNA catabolic process (GO:0016075)3.62780404
16positive regulation of mitochondrial fission (GO:0090141)3.60269570
17regulation of timing of cell differentiation (GO:0048505)3.58446306
18male meiosis I (GO:0007141)3.57080453
19histone H2B ubiquitination (GO:0033523)3.53147230
20negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.44402980
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.44219833
22keratinocyte development (GO:0003334)3.41030927
23histone H3-K9 methylation (GO:0051567)3.41028900
24poly(A)+ mRNA export from nucleus (GO:0016973)3.39861579
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31129839
26regulation of development, heterochronic (GO:0040034)3.30609082
27positive regulation by host of viral transcription (GO:0043923)3.30062340
28histone H2A acetylation (GO:0043968)3.29390643
29glycoprotein catabolic process (GO:0006516)3.28354080
30positive regulation of granulocyte differentiation (GO:0030854)3.28291320
31proline transport (GO:0015824)3.26409156
32gamma-aminobutyric acid transport (GO:0015812)3.21714260
33histone H3-K9 modification (GO:0061647)3.17067271
34ribonucleoprotein complex disassembly (GO:0032988)3.16588689
35DNA integration (GO:0015074)3.16381441
36spliceosomal complex assembly (GO:0000245)3.16196520
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.15935610
38cerebral cortex radially oriented cell migration (GO:0021799)3.14519181
39reciprocal DNA recombination (GO:0035825)3.11295886
40reciprocal meiotic recombination (GO:0007131)3.11295886
41preassembly of GPI anchor in ER membrane (GO:0016254)3.09346706
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.09130396
43intestinal cholesterol absorption (GO:0030299)3.01783248
44cell proliferation in forebrain (GO:0021846)3.01213505
45regulation of response to tumor cell (GO:0002834)3.00940178
46positive regulation of response to tumor cell (GO:0002836)3.00940178
47positive regulation of immune response to tumor cell (GO:0002839)3.00940178
48regulation of immune response to tumor cell (GO:0002837)3.00940178
49negative regulation of myoblast differentiation (GO:0045662)3.00844363
50positive regulation of histone H3-K4 methylation (GO:0051571)2.98683322
51centriole assembly (GO:0098534)2.98335403
52negative regulation of telomere maintenance (GO:0032205)2.98043845
53female gonad development (GO:0008585)2.97929319
54macroautophagy (GO:0016236)2.97300707
55protein heterotetramerization (GO:0051290)2.95204133
56mesenchymal cell differentiation involved in renal system development (GO:2001012)2.94292288
57mesenchymal cell differentiation involved in kidney development (GO:0072161)2.94292288
58head development (GO:0060322)2.93707748
59synaptic vesicle maturation (GO:0016188)2.92739601
60nonmotile primary cilium assembly (GO:0035058)2.92203571
61protein polyglutamylation (GO:0018095)2.90658786
62limb bud formation (GO:0060174)2.88016165
63aggressive behavior (GO:0002118)2.87687264
64righting reflex (GO:0060013)2.84584094
65meiotic chromosome segregation (GO:0045132)2.84448911
66endosome to lysosome transport (GO:0008333)2.84418977
67DNA methylation involved in gamete generation (GO:0043046)2.82553316
68one-carbon compound transport (GO:0019755)2.81496446
69positive regulation of translational initiation (GO:0045948)2.80171044
70microtubule depolymerization (GO:0007019)2.77532557
71mitochondrial fission (GO:0000266)2.76930812
72regulation of telomere maintenance via telomerase (GO:0032210)2.75854595
73cell morphogenesis involved in neuron differentiation (GO:0048667)2.75376838
74GPI anchor biosynthetic process (GO:0006506)2.75375464
75spinal cord development (GO:0021510)2.72197300
76organelle disassembly (GO:1903008)2.71228280
77protein localization to cilium (GO:0061512)2.69927111
78retinal rod cell development (GO:0046548)2.69236382
79left/right axis specification (GO:0070986)2.68426693
80regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.68064531
81axon ensheathment in central nervous system (GO:0032291)2.66856491
82central nervous system myelination (GO:0022010)2.66856491
83auditory behavior (GO:0031223)2.66788763
84epithelial cilium movement (GO:0003351)2.66740357
85negative regulation of interleukin-17 production (GO:0032700)2.66359856
86response to X-ray (GO:0010165)2.66212726
87neurotransmitter-gated ion channel clustering (GO:0072578)2.66036816
88respiratory chain complex IV assembly (GO:0008535)2.65107701
89brain morphogenesis (GO:0048854)2.63371502
90positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.62279737
91DNA strand renaturation (GO:0000733)2.62270386
92vascular smooth muscle contraction (GO:0014829)2.60968678
93cytochrome complex assembly (GO:0017004)2.60603028
94rRNA methylation (GO:0031167)2.59366162
95negative regulation of execution phase of apoptosis (GO:1900118)2.59277983
96negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58202021
97meiosis I (GO:0007127)2.55770942
98glycolipid biosynthetic process (GO:0009247)2.55675636
99chromosome organization involved in meiosis (GO:0070192)2.55095851
100positive regulation of protein homodimerization activity (GO:0090073)2.54516257
101developmental pigmentation (GO:0048066)2.53097342
102photoreceptor cell maintenance (GO:0045494)2.52581133
103regulation of histone H3-K4 methylation (GO:0051569)2.52557029
104amino sugar catabolic process (GO:0046348)2.51972814
105regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51856991
106positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.50435114
107rRNA modification (GO:0000154)2.50307783
108cilium or flagellum-dependent cell motility (GO:0001539)2.50112308
109protein localization to Golgi apparatus (GO:0034067)2.48904740
110positive regulation of interleukin-1 beta secretion (GO:0050718)2.48238159
111adenosine metabolic process (GO:0046085)2.48007606
112otic vesicle formation (GO:0030916)2.47908000
113regulation of platelet aggregation (GO:0090330)2.46637317
114polyol transport (GO:0015791)2.45624890
115GPI anchor metabolic process (GO:0006505)2.45263387
116germinal center formation (GO:0002467)2.43925037
117protein localization to synapse (GO:0035418)2.43847426
118cullin deneddylation (GO:0010388)2.43716602
119CENP-A containing nucleosome assembly (GO:0034080)2.43572168
120DNA damage response, detection of DNA damage (GO:0042769)2.43061114
121activation of MAPKKK activity (GO:0000185)2.42907954
122rhodopsin mediated signaling pathway (GO:0016056)2.42040546
123presynaptic membrane assembly (GO:0097105)2.41950298
124lymphoid progenitor cell differentiation (GO:0002320)2.41516774
125protein localization to peroxisome (GO:0072662)2.41398690
126protein targeting to peroxisome (GO:0006625)2.41398690
127establishment of protein localization to peroxisome (GO:0072663)2.41398690
128artery smooth muscle contraction (GO:0014824)2.41229877
129regulation of activation of Janus kinase activity (GO:0010533)2.40162285
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40087444
131cranial nerve morphogenesis (GO:0021602)2.39825417
132neurotransmitter secretion (GO:0007269)2.39715020
133ncRNA 3-end processing (GO:0043628)2.39386237
134startle response (GO:0001964)2.39053439
135ceramide catabolic process (GO:0046514)2.39024211
136forebrain morphogenesis (GO:0048853)2.38798712
137glycosphingolipid biosynthetic process (GO:0006688)2.38548879
138regulation of telomere maintenance (GO:0032204)2.38233379
139regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38207474
140positive regulation of glycolytic process (GO:0045821)2.37838358
141male meiosis (GO:0007140)2.37472595
142intra-Golgi vesicle-mediated transport (GO:0006891)2.37466646
143sympathetic nervous system development (GO:0048485)2.37419871
144DNA ligation (GO:0006266)2.37260222
145retinal cone cell development (GO:0046549)2.37018675
146photoreceptor cell differentiation (GO:0046530)2.36068067
147eye photoreceptor cell differentiation (GO:0001754)2.36068067
148positive regulation of histone methylation (GO:0031062)2.35766381
149ubiquinone metabolic process (GO:0006743)2.35761841
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.35197936
151regulation of mRNA splicing, via spliceosome (GO:0048024)2.35159454
152spinal cord motor neuron differentiation (GO:0021522)2.35123383
153cholesterol efflux (GO:0033344)2.34901846
154oligosaccharide catabolic process (GO:0009313)2.34723377
155tRNA methylation (GO:0030488)2.34481519
156C-terminal protein amino acid modification (GO:0018410)2.34046030
157histamine secretion (GO:0001821)2.31045652
158histone H3-K4 trimethylation (GO:0080182)2.29200591
159glycosphingolipid catabolic process (GO:0046479)2.28518296
160piRNA metabolic process (GO:0034587)2.27610036
161centriole replication (GO:0007099)2.26784686
162mannosylation (GO:0097502)2.26368020
163chromatin remodeling at centromere (GO:0031055)2.24772318
164positive regulation of interleukin-1 secretion (GO:0050716)2.24043343
165positive regulation of uterine smooth muscle contraction (GO:0070474)2.23967880
166single strand break repair (GO:0000012)2.23773708
167superoxide metabolic process (GO:0006801)2.22151671
168long-chain fatty acid biosynthetic process (GO:0042759)2.21584918
169eye photoreceptor cell development (GO:0042462)2.21509214
170Notch signaling involved in heart development (GO:0061314)2.21139453
171regulation of NIK/NF-kappaB signaling (GO:1901222)2.20370554
172protein K6-linked ubiquitination (GO:0085020)2.19967441
173dendritic cell chemotaxis (GO:0002407)2.19088605
174DNA synthesis involved in DNA repair (GO:0000731)2.18534977
175proteasome assembly (GO:0043248)2.17675785
176retina layer formation (GO:0010842)2.17675204
177presynaptic membrane organization (GO:0097090)2.16835034
178C-terminal protein lipidation (GO:0006501)2.16352184
179cell differentiation involved in metanephros development (GO:0072202)2.14049220
180negative regulation of DNA-templated transcription, elongation (GO:0032785)2.13377339
181negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.13377339
182tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.12990652
183RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.12990652
184G-protein coupled receptor internalization (GO:0002031)2.12950866
185termination of RNA polymerase III transcription (GO:0006386)2.11233254
186transcription elongation from RNA polymerase III promoter (GO:0006385)2.11233254
187transcription elongation from RNA polymerase I promoter (GO:0006362)2.10673151
188termination of RNA polymerase I transcription (GO:0006363)2.09188012
189response to redox state (GO:0051775)2.09150315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human3.38100686
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33934037
3GBX2_23144817_ChIP-Seq_PC3_Human3.32723882
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.25405532
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.00130729
6ZNF274_21170338_ChIP-Seq_K562_Hela2.99696798
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91805379
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.86865077
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.86564038
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84153390
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83181604
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.78888056
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.68991480
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65368701
15IGF1R_20145208_ChIP-Seq_DFB_Human2.64785899
16VDR_22108803_ChIP-Seq_LS180_Human2.57281606
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52632313
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.49576271
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43263419
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42901564
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.38574888
22NFE2_27457419_Chip-Seq_LIVER_Mouse2.36932159
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33842611
24VDR_23849224_ChIP-Seq_CD4+_Human2.33368261
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27010276
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.16672606
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14817205
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13958036
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.13798213
30EZH2_27294783_Chip-Seq_NPCs_Mouse2.11767553
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06814945
32CIITA_25753668_ChIP-Seq_RAJI_Human2.06457325
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05940963
34TP53_22573176_ChIP-Seq_HFKS_Human1.96873551
35IRF1_19129219_ChIP-ChIP_H3396_Human1.96851067
36EZH2_22144423_ChIP-Seq_EOC_Human1.96501882
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.93529193
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93330412
39* ETS1_20019798_ChIP-Seq_JURKAT_Human1.92832061
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.92199508
41ELK1_19687146_ChIP-ChIP_HELA_Human1.91978450
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.90041576
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.88144849
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85138993
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.85022139
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.81853323
47P53_22387025_ChIP-Seq_ESCs_Mouse1.81389318
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.81195839
49EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.81061739
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.79374383
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78664382
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.77336274
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76807682
54TAF15_26573619_Chip-Seq_HEK293_Human1.76598803
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74228354
56P300_18555785_Chip-Seq_ESCs_Mouse1.72972501
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72784856
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.68911611
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.68003341
60FUS_26573619_Chip-Seq_HEK293_Human1.67603338
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.67546707
62P300_19829295_ChIP-Seq_ESCs_Human1.67048073
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.65762135
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65158741
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.65024304
66RNF2_27304074_Chip-Seq_NSC_Mouse1.63493180
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62887950
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.62776194
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.62738654
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.60766544
71* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58440234
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.57551185
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.55429314
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54523184
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.52838026
76PU1_27457419_Chip-Seq_LIVER_Mouse1.51546715
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49572010
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.49556743
79MYC_18940864_ChIP-ChIP_HL60_Human1.49168217
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47582765
81* FOXP3_21729870_ChIP-Seq_TREG_Human1.47225459
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46424311
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46220745
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46202624
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45998859
86SMAD1_18555785_Chip-Seq_ESCs_Mouse1.44898813
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.44845255
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40616676
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39276074
90* DCP1A_22483619_ChIP-Seq_HELA_Human1.38906320
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.37069832
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.36853780
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34921602
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34670179
95EWS_26573619_Chip-Seq_HEK293_Human1.34654569
96ER_23166858_ChIP-Seq_MCF-7_Human1.33709884
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32432862
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31872611
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31755605
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.31242506
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30586785
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30328451
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30224934
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.30211758
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28700863
106GABP_19822575_ChIP-Seq_HepG2_Human1.28650889
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26420118
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25585913
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23951298
110* REST_18959480_ChIP-ChIP_MESCs_Mouse1.22735070
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21511076
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20033488
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19338944
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17959749
115AR_21572438_ChIP-Seq_LNCaP_Human1.17135435
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.16862906
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16862906
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16176194
119SMAD4_21799915_ChIP-Seq_A2780_Human1.15527859
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15508879
121KDM5A_27292631_Chip-Seq_BREAST_Human1.14503120
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12180329
123RNF2_27304074_Chip-Seq_ESCs_Mouse1.12066036
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.11088933
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10751927
126CBP_20019798_ChIP-Seq_JUKART_Human1.10751927
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09701790
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09584013
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09366184
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09366184
131STAT3_23295773_ChIP-Seq_U87_Human1.06816860
132RUNX2_22187159_ChIP-Seq_PCA_Human1.06778754
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05016304
134KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04761278
135HTT_18923047_ChIP-ChIP_STHdh_Human1.04531442
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03625676
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02993370
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02652666
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02477317
140TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02446463
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01687499
142KDM2B_26808549_Chip-Seq_REH_Human1.01627243
143WT1_19549856_ChIP-ChIP_CCG9911_Human1.01404161
144EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00882973
145RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00882973
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00689376
147TCF4_23295773_ChIP-Seq_U87_Human1.00281506
148SALL1_21062744_ChIP-ChIP_HESCs_Human0.94956389
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94803857
150* TTF2_22483619_ChIP-Seq_HELA_Human0.93232781
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92984775
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.92221328
153THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90111770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.21430384
2MP0004147_increased_porphyrin_level3.85541487
3MP0006292_abnormal_olfactory_placode3.61876200
4MP0001188_hyperpigmentation3.22823664
5MP0005171_absent_coat_pigmentation3.17645829
6MP0000013_abnormal_adipose_tissue2.99683029
7MP0002102_abnormal_ear_morphology2.96131420
8MP0000566_synostosis2.84630156
9MP0000569_abnormal_digit_pigmentation2.69972225
10MP0003656_abnormal_erythrocyte_physiolo2.65380422
11MP0008058_abnormal_DNA_repair2.61662661
12MP0000015_abnormal_ear_pigmentation2.52620157
13MP0005409_darkened_coat_color2.40660314
14MP0002638_abnormal_pupillary_reflex2.30737496
15MP0004145_abnormal_muscle_electrophysio2.30042110
16MP0002822_catalepsy2.20906726
17MP0004381_abnormal_hair_follicle2.11348786
18MP0002277_abnormal_respiratory_mucosa2.04774475
19MP0008995_early_reproductive_senescence2.04183393
20MP0005174_abnormal_tail_pigmentation1.96809716
21MP0008057_abnormal_DNA_replication1.92457933
22MP0006072_abnormal_retinal_apoptosis1.89731223
23MP0003787_abnormal_imprinting1.87240688
24MP0009697_abnormal_copulation1.85494522
25MP0008877_abnormal_DNA_methylation1.85209770
26MP0002160_abnormal_reproductive_system1.83840004
27MP0003172_abnormal_lysosome_physiology1.76460758
28MP0001986_abnormal_taste_sensitivity1.75919622
29MP0003941_abnormal_skin_development1.74952956
30MP0003880_abnormal_central_pattern1.74585655
31MP0005551_abnormal_eye_electrophysiolog1.73423529
32MP0002272_abnormal_nervous_system1.66198895
33MP0003890_abnormal_embryonic-extraembry1.65870908
34MP0003123_paternal_imprinting1.64861201
35MP0003122_maternal_imprinting1.60650281
36MP0000383_abnormal_hair_follicle1.56838829
37MP0004885_abnormal_endolymph1.56286587
38MP0005253_abnormal_eye_physiology1.55870746
39MP0002938_white_spotting1.52058350
40MP0002572_abnormal_emotion/affect_behav1.49102025
41MP0005379_endocrine/exocrine_gland_phen1.45461152
42MP0003635_abnormal_synaptic_transmissio1.43988651
43MP0003938_abnormal_ear_development1.43687423
44MP0000049_abnormal_middle_ear1.42856686
45MP0003221_abnormal_cardiomyocyte_apopto1.41997301
46MP0000026_abnormal_inner_ear1.41454239
47MP0004924_abnormal_behavior1.40773867
48MP0005386_behavior/neurological_phenoty1.40773867
49MP0010386_abnormal_urinary_bladder1.39265501
50MP0004742_abnormal_vestibular_system1.38367256
51MP0003111_abnormal_nucleus_morphology1.37608901
52MP0008260_abnormal_autophagy1.36821020
53MP0003283_abnormal_digestive_organ1.36284418
54MP0005646_abnormal_pituitary_gland1.36089569
55MP0010094_abnormal_chromosome_stability1.35727605
56MP0005451_abnormal_body_composition1.34872794
57MP0000372_irregular_coat_pigmentation1.31743223
58MP0003693_abnormal_embryo_hatching1.31691790
59MP0003786_premature_aging1.31451652
60MP0002229_neurodegeneration1.30892939
61MP0005645_abnormal_hypothalamus_physiol1.29405445
62MP0001929_abnormal_gametogenesis1.28744959
63MP0005670_abnormal_white_adipose1.28249814
64MP0005503_abnormal_tendon_morphology1.25920575
65MP0002063_abnormal_learning/memory/cond1.25060156
66MP0003724_increased_susceptibility_to1.24630509
67MP0003698_abnormal_male_reproductive1.24378825
68MP0003950_abnormal_plasma_membrane1.24056211
69MP0002064_seizures1.23098803
70MP0003943_abnormal_hepatobiliary_system1.22145942
71MP0002067_abnormal_sensory_capabilities1.21955033
72MP0009745_abnormal_behavioral_response1.17064632
73MP0001963_abnormal_hearing_physiology1.14054079
74MP0003315_abnormal_perineum_morphology1.13955770
75MP0002095_abnormal_skin_pigmentation1.13818223
76MP0002184_abnormal_innervation1.11968422
77MP0001486_abnormal_startle_reflex1.10783879
78MP0000003_abnormal_adipose_tissue1.09421951
79MP0003567_abnormal_fetal_cardiomyocyte1.08537724
80MP0000613_abnormal_salivary_gland1.07986933
81MP0003937_abnormal_limbs/digits/tail_de1.07720427
82MP0002557_abnormal_social/conspecific_i1.07605152
83MP0002837_dystrophic_cardiac_calcinosis1.07574656
84MP0005377_hearing/vestibular/ear_phenot1.06658083
85MP0003878_abnormal_ear_physiology1.06658083
86MP0002876_abnormal_thyroid_physiology1.06110549
87MP0003137_abnormal_impulse_conducting1.05894201
88MP0004859_abnormal_synaptic_plasticity1.05353482
89MP0003718_maternal_effect1.03628122
90MP0005394_taste/olfaction_phenotype1.03333472
91MP0005499_abnormal_olfactory_system1.03333472
92MP0008932_abnormal_embryonic_tissue1.03062353
93MP0002177_abnormal_outer_ear1.01156319
94MP0005389_reproductive_system_phenotype0.98055111
95MP0001501_abnormal_sleep_pattern0.97805355
96MP0006276_abnormal_autonomic_nervous0.97758127
97MP0008569_lethality_at_weaning0.97397858
98MP0005423_abnormal_somatic_nervous0.96936748
99MP0002909_abnormal_adrenal_gland0.96858537
100MP0001485_abnormal_pinna_reflex0.96171770
101MP0005671_abnormal_response_to0.96163504
102MP0002751_abnormal_autonomic_nervous0.96039796
103MP0001145_abnormal_male_reproductive0.95797617
104MP0001270_distended_abdomen0.94546106
105MP0004811_abnormal_neuron_physiology0.91375166
106MP0000631_abnormal_neuroendocrine_gland0.91201706
107MP0008789_abnormal_olfactory_epithelium0.90898069
108MP0004270_analgesia0.90321145
109MP0005075_abnormal_melanosome_morpholog0.89349056
110MP0001905_abnormal_dopamine_level0.89071981
111MP0001529_abnormal_vocalization0.88898352
112MP0002882_abnormal_neuron_morphology0.87753863
113MP0004142_abnormal_muscle_tone0.87211435
114MP0002132_abnormal_respiratory_system0.86838175
115MP0002752_abnormal_somatic_nervous0.86667939
116MP0009250_abnormal_appendicular_skeleto0.84465499
117MP0008872_abnormal_physiological_respon0.83734910
118MP0005623_abnormal_meninges_morphology0.83549114
119MP0000653_abnormal_sex_gland0.83353530
120MP0001186_pigmentation_phenotype0.83007350
121MP0002735_abnormal_chemical_nociception0.82457837
122MP0008007_abnormal_cellular_replicative0.80944037
123MP0002249_abnormal_larynx_morphology0.80501837
124MP0001764_abnormal_homeostasis0.79826874
125MP0002734_abnormal_mechanical_nocicepti0.79690746
126MP0002066_abnormal_motor_capabilities/c0.79527058
127MP0002163_abnormal_gland_morphology0.79495493
128MP0001879_abnormal_lymphatic_vessel0.78881218
129MP0006035_abnormal_mitochondrial_morpho0.78606384
130MP0002127_abnormal_cardiovascular_syste0.78430728
131MP0005535_abnormal_body_temperature0.78134286
132MP0001346_abnormal_lacrimal_gland0.78064891
133MP0009384_cardiac_valve_regurgitation0.77334707
134MP0000647_abnormal_sebaceous_gland0.77203093
135MP0002210_abnormal_sex_determination0.76111246
136MP0008775_abnormal_heart_ventricle0.75865779
137MP0009765_abnormal_xenobiotic_induced0.75372978
138MP0008873_increased_physiological_sensi0.75257224
139MP0002148_abnormal_hypersensitivity_rea0.74183712
140MP0000778_abnormal_nervous_system0.73418444
141MP0002009_preneoplasia0.73037688
142MP0005391_vision/eye_phenotype0.73020721
143MP0000462_abnormal_digestive_system0.72810030
144MP0005195_abnormal_posterior_eye0.72380717
145MP0004133_heterotaxia0.71887269
146MP0001502_abnormal_circadian_rhythm0.71636273
147MP0001835_abnormal_antigen_presentation0.71466881
148MP0009046_muscle_twitch0.71259658
149MP0003121_genomic_imprinting0.70458384
150MP0003690_abnormal_glial_cell0.70134367
151MP0004484_altered_response_of0.69901610
152MP0000762_abnormal_tongue_morphology0.69864912
153MP0001944_abnormal_pancreas_morphology0.69539945
154MP0002693_abnormal_pancreas_physiology0.68959530
155MP0004808_abnormal_hematopoietic_stem0.68747836
156MP0003077_abnormal_cell_cycle0.68581383
157MP0002069_abnormal_eating/drinking_beha0.68515516
158MP0001984_abnormal_olfaction0.67806990
159MP0006036_abnormal_mitochondrial_physio0.67769945
160MP0000639_abnormal_adrenal_gland0.67674810
161MP0002098_abnormal_vibrissa_morphology0.66503952
162MP0002075_abnormal_coat/hair_pigmentati0.63022679
163MP0001324_abnormal_eye_pigmentation0.62706421

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.93868032
2Chromsome breakage (HP:0040012)6.25011663
3Duplicated collecting system (HP:0000081)4.28600121
4Retinal atrophy (HP:0001105)4.25676355
5Cerebellar dysplasia (HP:0007033)4.09032110
6Abnormality of the renal collecting system (HP:0004742)3.92582307
7Congenital stationary night blindness (HP:0007642)3.63238286
8Fatigue (HP:0012378)3.58731927
93-Methylglutaconic aciduria (HP:0003535)3.57194464
10Genetic anticipation (HP:0003743)3.47250111
11Volvulus (HP:0002580)3.40344181
12Type II lissencephaly (HP:0007260)3.34661753
13Meckel diverticulum (HP:0002245)3.28069367
14Progressive cerebellar ataxia (HP:0002073)3.26071843
15Prostate neoplasm (HP:0100787)3.19100815
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.16039049
17Scanning speech (HP:0002168)3.15623845
18Abnormality of the ileum (HP:0001549)3.15066660
19Septo-optic dysplasia (HP:0100842)3.12661566
20Abnormality of the preputium (HP:0100587)3.12498696
21Abnormality of the renal cortex (HP:0011035)3.03781375
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.03261599
23Retinal dysplasia (HP:0007973)3.00761651
24Constricted visual fields (HP:0001133)2.92334103
25Gaze-evoked nystagmus (HP:0000640)2.88598095
26Hand muscle atrophy (HP:0009130)2.86931499
27Upper limb muscle weakness (HP:0003484)2.82249471
28Abnormality of the corticospinal tract (HP:0002492)2.80682300
29Abnormality of DNA repair (HP:0003254)2.80413479
30Amyotrophic lateral sclerosis (HP:0007354)2.72202881
31Overlapping toe (HP:0001845)2.69916884
32Ectopic kidney (HP:0000086)2.67939203
33True hermaphroditism (HP:0010459)2.65243043
34Abnormality of chromosome stability (HP:0003220)2.62220372
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58049893
36Clubbing of toes (HP:0100760)2.57584046
37Gait imbalance (HP:0002141)2.56535613
38Polydipsia (HP:0001959)2.56180024
39Abnormal drinking behavior (HP:0030082)2.56180024
40Occipital encephalocele (HP:0002085)2.50281833
41Osteomalacia (HP:0002749)2.47091685
42Febrile seizures (HP:0002373)2.46915461
43Hypoglycemic coma (HP:0001325)2.45165986
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.36106394
45Absent radius (HP:0003974)2.34959946
46Nephroblastoma (Wilms tumor) (HP:0002667)2.34289122
47Reticulocytopenia (HP:0001896)2.33565072
48Pancreatic cysts (HP:0001737)2.33023854
49Papilledema (HP:0001085)2.31808673
50Abnormality of the lower motor neuron (HP:0002366)2.29498895
51Median cleft lip (HP:0000161)2.29090043
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.28703382
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.28703382
54Absent forearm bone (HP:0003953)2.27936875
55Aplasia involving forearm bones (HP:0009822)2.27936875
56Pancreatic fibrosis (HP:0100732)2.27365380
57Absent/shortened dynein arms (HP:0200106)2.26946596
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.26946596
59Aplasia cutis congenita (HP:0001057)2.26345606
60Cerebral hypomyelination (HP:0006808)2.26259361
61Attenuation of retinal blood vessels (HP:0007843)2.26202281
62Preaxial hand polydactyly (HP:0001177)2.25138222
63Decreased central vision (HP:0007663)2.23643080
64Hypoplasia of the fovea (HP:0007750)2.23014328
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.23014328
66Hypoglycemic seizures (HP:0002173)2.22505380
67Disinhibition (HP:0000734)2.22143123
68Duplication of thumb phalanx (HP:0009942)2.20721964
69Abnormality of midbrain morphology (HP:0002418)2.20596752
70Molar tooth sign on MRI (HP:0002419)2.20596752
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20450717
72White forelock (HP:0002211)2.20101700
73Metaphyseal dysplasia (HP:0100255)2.19304077
74Abnormality of the pons (HP:0007361)2.18168670
75Prominent metopic ridge (HP:0005487)2.16397321
76Embryonal renal neoplasm (HP:0011794)2.15903424
77Abnormal ciliary motility (HP:0012262)2.14057596
78Chronic hepatic failure (HP:0100626)2.12350748
79Tubulointerstitial nephritis (HP:0001970)2.12180068
80Parakeratosis (HP:0001036)2.10969139
81Optic nerve hypoplasia (HP:0000609)2.10377240
82Triphalangeal thumb (HP:0001199)2.09411773
83Optic disc pallor (HP:0000543)2.08957220
84Small intestinal stenosis (HP:0012848)2.08248162
85Duodenal stenosis (HP:0100867)2.08248162
86Abnormal respiratory motile cilium physiology (HP:0012261)2.08018471
87Renal cortical cysts (HP:0000803)2.06153740
88Panhypogammaglobulinemia (HP:0003139)2.05647006
89Increased corneal curvature (HP:0100692)2.05616937
90Keratoconus (HP:0000563)2.05616937
91Mutism (HP:0002300)2.05140416
92Patchy hypopigmentation of hair (HP:0011365)2.03033491
93Tubulointerstitial abnormality (HP:0001969)2.02201479
94Abnormal rod and cone electroretinograms (HP:0008323)2.01912304
95Intestinal atresia (HP:0011100)2.01570901
96Abnormality of macular pigmentation (HP:0008002)2.01565729
97Short thumb (HP:0009778)2.01374095
98Abnormality of the prostate (HP:0008775)2.00601726
99Hypoplasia of the pons (HP:0012110)1.97804223
100Bone marrow hypocellularity (HP:0005528)1.97562490
101Urinary bladder sphincter dysfunction (HP:0002839)1.97446434
102Aplasia/Hypoplasia of the lens (HP:0008063)1.97089710
103Absent septum pellucidum (HP:0001331)1.96862575
104Abnormality of the nasal septum (HP:0000419)1.96854700
105Male pseudohermaphroditism (HP:0000037)1.96067143
106Dyskinesia (HP:0100660)1.95177484
107Medial flaring of the eyebrow (HP:0010747)1.94726427
108Abnormality of the septum pellucidum (HP:0007375)1.93560376
109Adrenal hypoplasia (HP:0000835)1.92628953
110Limb dystonia (HP:0002451)1.91281724
111Obstructive lung disease (HP:0006536)1.91078899
112Chronic obstructive pulmonary disease (HP:0006510)1.91078899
113CNS hypomyelination (HP:0003429)1.90748150
114Abnormality of incisor morphology (HP:0011063)1.90019102
115Genital tract atresia (HP:0001827)1.89993612
116Oligohydramnios (HP:0001562)1.88873553
117Aplasia of the musculature (HP:0100854)1.88581935
118Congenital hepatic fibrosis (HP:0002612)1.88496265
119Decreased testicular size (HP:0008734)1.88489927
120Hyperinsulinemic hypoglycemia (HP:0000825)1.88403651
121Stomach cancer (HP:0012126)1.88320080
122Abnormality of the carotid arteries (HP:0005344)1.87747131
123Severe muscular hypotonia (HP:0006829)1.87466005
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.85609304
125Postaxial foot polydactyly (HP:0001830)1.85226384
126Nephrogenic diabetes insipidus (HP:0009806)1.85154676
127Vaginal atresia (HP:0000148)1.84638410
128Abolished electroretinogram (ERG) (HP:0000550)1.84281590
129Muscle hypertrophy of the lower extremities (HP:0008968)1.84159954
130Abnormality of the metopic suture (HP:0005556)1.84059837
131Congenital sensorineural hearing impairment (HP:0008527)1.83313832
132Hypsarrhythmia (HP:0002521)1.82639226
133Abnormality of secondary sexual hair (HP:0009888)1.82584109
134Abnormality of the axillary hair (HP:0100134)1.82584109
135Dyschromatopsia (HP:0007641)1.81825003
136Prolonged neonatal jaundice (HP:0006579)1.80817240
137Buphthalmos (HP:0000557)1.80061000
138Nephronophthisis (HP:0000090)1.79730155
139Abnormality of the duodenum (HP:0002246)1.78992501
140Lissencephaly (HP:0001339)1.77928903
141Abnormality of the columella (HP:0009929)1.77756545
142Polyphagia (HP:0002591)1.77519397
143Renal agenesis (HP:0000104)1.77021695
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75755057
145Severe combined immunodeficiency (HP:0004430)1.73423497
146Facial cleft (HP:0002006)1.73296067
147Specific learning disability (HP:0001328)1.73018164
148Sex reversal (HP:0012245)1.72920956
149Abnormal sex determination (HP:0012244)1.72920956
150Astigmatism (HP:0000483)1.72076277
151EEG with generalized epileptiform discharges (HP:0011198)1.71969565
152Intellectual disability, profound (HP:0002187)1.71838536
153Abnormality of the renal medulla (HP:0100957)1.71369700
154Type I transferrin isoform profile (HP:0003642)1.71304152
155Atelectasis (HP:0100750)1.70909460
156Abnormal respiratory epithelium morphology (HP:0012253)1.70416788
157Abnormal respiratory motile cilium morphology (HP:0005938)1.70416788
158Congenital primary aphakia (HP:0007707)1.69036402
159Progressive microcephaly (HP:0000253)1.68395195
160Abnormal biliary tract physiology (HP:0012439)1.68331132
161Bile duct proliferation (HP:0001408)1.68331132
162Amblyopia (HP:0000646)1.68304655
163Hypergonadotropic hypogonadism (HP:0000815)1.68260660
164Abnormality of the musculature of the hand (HP:0001421)1.67817549
165Epidermoid cyst (HP:0200040)1.67543700
166Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67503629
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67079909
168Aganglionic megacolon (HP:0002251)1.66989365
169Morphological abnormality of the pyramidal tract (HP:0002062)1.66119643
170Albinism (HP:0001022)1.64649899
171Hypothermia (HP:0002045)1.64610092
172Hepatic necrosis (HP:0002605)1.64220567
173Degeneration of anterior horn cells (HP:0002398)1.63475393
174Abnormality of the anterior horn cell (HP:0006802)1.63475393
175Hypoplastic iliac wings (HP:0002866)1.63006653
176Polyuria (HP:0000103)1.62728273
177Epileptiform EEG discharges (HP:0011182)1.62674246
178Distal upper limb amyotrophy (HP:0007149)1.62579763
179Upper limb amyotrophy (HP:0009129)1.62579763
180Hepatocellular necrosis (HP:0001404)1.60931391
181Emotional lability (HP:0000712)1.60908092
182Progressive inability to walk (HP:0002505)1.60766110
183Abnormality of the pancreatic islet cells (HP:0006476)1.60600566
184Abnormality of endocrine pancreas physiology (HP:0012093)1.60600566
185Multicystic kidney dysplasia (HP:0000003)1.59538906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRPM74.35213652
2MAP4K23.50404370
3STK163.35464722
4TNIK3.26780664
5IRAK33.18282399
6ZAK3.10320241
7CASK3.03685962
8CDK192.97014566
9MAP3K42.51454410
10MKNK22.50571430
11MAP3K62.44925207
12MARK32.36488538
13IRAK42.35674420
14BLK2.26519961
15EIF2AK22.21307307
16INSRR2.16979957
17GRK12.16621011
18SRPK11.96633633
19TXK1.85765460
20MAP2K41.82288209
21MKNK11.80910255
22NUAK11.76752385
23CAMKK21.74075654
24MAP2K71.65843780
25CLK11.64426929
26IRAK11.64053509
27ALK1.61786817
28MAP3K141.60775887
29PLK41.57977352
30IRAK21.55123606
31VRK11.54019383
32NEK61.50604020
33BMPR1B1.46727930
34MAP2K61.44921249
35PDK21.44044811
36FRK1.41868957
37DAPK21.41570551
38MATK1.41438374
39ADRBK21.40904624
40BRD41.40319495
41AKT31.39236438
42TEC1.38547270
43BMPR21.35321422
44BRSK21.33242706
45NLK1.30232694
46PBK1.29442135
47FLT31.24151012
48EPHA31.23648812
49PKN11.19992350
50MINK11.18852013
51YES11.17669583
52CDK31.15596296
53UHMK11.13803416
54CSNK1G31.10840628
55TNK21.10303831
56BCKDK1.07524141
57CSNK1G11.07433182
58STK38L1.06236590
59GRK71.03751140
60EPHA41.03105680
61LATS11.01508036
62DYRK30.99695530
63WNK30.99402984
64TLK10.97494366
65ITK0.96474850
66PAK30.95692409
67CSNK1A1L0.95551152
68TRIM280.94734977
69MAPK130.94451701
70WNK40.94155471
71CAMKK10.91989727
72MAPK150.91664647
73BRSK10.90836908
74PNCK0.89737963
75MAP3K120.88133305
76CSNK1G20.84439952
77SIK30.79218634
78IKBKB0.78118513
79DYRK20.77621200
80ATR0.77276253
81PRKCE0.74025494
82PLK10.74018738
83CDK70.73430876
84MUSK0.71958794
85TTK0.69381835
86FGFR20.68183790
87PLK20.68054743
88TIE10.66801948
89LYN0.65822954
90PLK30.64608257
91FGFR30.64598946
92PRKCG0.63294249
93NEK10.61802066
94RET0.61272708
95DYRK1A0.60485673
96CDC70.59272114
97RPS6KA50.58084152
98EIF2AK30.57391772
99FGR0.56747270
100STK100.56136600
101PINK10.55638912
102CHEK20.54953204
103CSNK1D0.54326619
104AURKB0.53128471
105PRKCH0.52970981
106EPHB20.52223823
107ERBB30.51892362
108PAK60.51736819
109DMPK0.50551485
110TESK20.50265216
111MAP3K50.49808935
112MAPK100.49766083
113ACVR1B0.48323193
114PIM10.47548064
115KIT0.47149781
116BTK0.47117015
117STK40.46550401
118CDC42BPA0.46205666
119MARK10.45940283
120PRKAA10.45106258
121CAMK10.45029974
122FER0.44477297
123PRPF4B0.44372665
124STK390.43874746
125IGF1R0.43522556
126MAPK70.43483372
127KSR10.43030868
128CHUK0.42674114
129SIK20.42147944
130OXSR10.41997873
131AURKA0.41229650
132STK110.41123667
133LCK0.41018169
134EPHA20.40797260
135BCR0.40441640
136ABL10.40418626
137CDK90.40134964
138BUB10.39371131
139TAOK30.38827341
140ERBB40.37920682
141NTRK30.37517435
142SGK20.36102559
143CAMK2B0.35932764
144FGFR40.35641814
145ATM0.35520218
146HCK0.35185796
147CSNK1E0.34751994
148RIPK40.34290377
149CDK80.33452303
150CAMK2A0.33401989
151MAP2K20.32435935
152PRKCQ0.31768203
153IKBKE0.30971189
154CSNK2A10.30278251
155ILK0.30225974
156PIK3CG0.30193596
157CDK50.29775610
158PASK0.29102709
159MAPKAPK50.29054534

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.25199502
2Fanconi anemia pathway_Homo sapiens_hsa034603.25409000
3Phototransduction_Homo sapiens_hsa047442.96891523
4RNA polymerase_Homo sapiens_hsa030202.44804773
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33278155
6Non-homologous end-joining_Homo sapiens_hsa034502.28130140
7Homologous recombination_Homo sapiens_hsa034402.20163442
8Butanoate metabolism_Homo sapiens_hsa006502.18887023
9Collecting duct acid secretion_Homo sapiens_hsa049662.03320946
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00265156
11Type I diabetes mellitus_Homo sapiens_hsa049401.97443387
12Basal transcription factors_Homo sapiens_hsa030221.95497108
13Synaptic vesicle cycle_Homo sapiens_hsa047211.85305128
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84939031
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.77983244
16Arachidonic acid metabolism_Homo sapiens_hsa005901.70385687
17Linoleic acid metabolism_Homo sapiens_hsa005911.70214196
18Nicotine addiction_Homo sapiens_hsa050331.68846226
19Ether lipid metabolism_Homo sapiens_hsa005651.61905352
20Sphingolipid metabolism_Homo sapiens_hsa006001.60076993
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57248955
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.52686330
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52646554
24Pyrimidine metabolism_Homo sapiens_hsa002401.51113148
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51091382
26Amphetamine addiction_Homo sapiens_hsa050311.50843640
27Insulin secretion_Homo sapiens_hsa049111.49539619
28Autoimmune thyroid disease_Homo sapiens_hsa053201.47763839
29Asthma_Homo sapiens_hsa053101.47398277
30Selenocompound metabolism_Homo sapiens_hsa004501.44935617
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44506657
32Mismatch repair_Homo sapiens_hsa034301.43607501
33GABAergic synapse_Homo sapiens_hsa047271.43366965
34Dopaminergic synapse_Homo sapiens_hsa047281.42878444
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39384246
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34696737
37Nucleotide excision repair_Homo sapiens_hsa034201.34422318
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.34275458
39Spliceosome_Homo sapiens_hsa030401.33964128
40Vitamin digestion and absorption_Homo sapiens_hsa049771.32930314
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32720168
42Purine metabolism_Homo sapiens_hsa002301.31039007
43DNA replication_Homo sapiens_hsa030301.30398086
44Graft-versus-host disease_Homo sapiens_hsa053321.26621811
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25589500
46Other glycan degradation_Homo sapiens_hsa005111.25529636
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24501864
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21953670
49Hematopoietic cell lineage_Homo sapiens_hsa046401.21624546
50Allograft rejection_Homo sapiens_hsa053301.21242967
51Olfactory transduction_Homo sapiens_hsa047401.17319288
52Base excision repair_Homo sapiens_hsa034101.15969395
53ABC transporters_Homo sapiens_hsa020101.15134505
54Oxidative phosphorylation_Homo sapiens_hsa001901.13526946
55Nitrogen metabolism_Homo sapiens_hsa009101.12573273
56Primary immunodeficiency_Homo sapiens_hsa053401.09481272
57Peroxisome_Homo sapiens_hsa041461.08030561
58Steroid biosynthesis_Homo sapiens_hsa001001.05969078
59Cocaine addiction_Homo sapiens_hsa050301.02395140
60Salivary secretion_Homo sapiens_hsa049700.99231862
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97438355
62RNA degradation_Homo sapiens_hsa030180.92874406
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92360030
64Serotonergic synapse_Homo sapiens_hsa047260.90245124
65p53 signaling pathway_Homo sapiens_hsa041150.90158137
66Parkinsons disease_Homo sapiens_hsa050120.89594762
67Measles_Homo sapiens_hsa051620.89454772
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88438417
69Cell cycle_Homo sapiens_hsa041100.88408268
70Taste transduction_Homo sapiens_hsa047420.87973627
71Legionellosis_Homo sapiens_hsa051340.87960660
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.87736006
73Rheumatoid arthritis_Homo sapiens_hsa053230.86350949
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85220086
75Morphine addiction_Homo sapiens_hsa050320.84975093
76Fatty acid metabolism_Homo sapiens_hsa012120.84970489
77Circadian entrainment_Homo sapiens_hsa047130.84531177
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84413422
79mTOR signaling pathway_Homo sapiens_hsa041500.83403311
80Protein export_Homo sapiens_hsa030600.83341071
81Herpes simplex infection_Homo sapiens_hsa051680.82061088
82Sulfur metabolism_Homo sapiens_hsa009200.81734299
83Malaria_Homo sapiens_hsa051440.76239164
84Ribosome_Homo sapiens_hsa030100.74140914
85Propanoate metabolism_Homo sapiens_hsa006400.72106377
86mRNA surveillance pathway_Homo sapiens_hsa030150.71447366
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70922551
88Renin secretion_Homo sapiens_hsa049240.68633465
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68578522
90Vibrio cholerae infection_Homo sapiens_hsa051100.68168399
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67653974
92Histidine metabolism_Homo sapiens_hsa003400.66188957
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66006487
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65888577
95Notch signaling pathway_Homo sapiens_hsa043300.64359480
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63925162
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62977359
98African trypanosomiasis_Homo sapiens_hsa051430.62963565
99Fat digestion and absorption_Homo sapiens_hsa049750.62486802
100Type II diabetes mellitus_Homo sapiens_hsa049300.60610560
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59502599
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59195838
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57829776
104Basal cell carcinoma_Homo sapiens_hsa052170.57012329
105Proteasome_Homo sapiens_hsa030500.56872183
106Glucagon signaling pathway_Homo sapiens_hsa049220.56597830
107Calcium signaling pathway_Homo sapiens_hsa040200.56138800
108Glycerolipid metabolism_Homo sapiens_hsa005610.55283470
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55011171
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.54974179
111Arginine and proline metabolism_Homo sapiens_hsa003300.54772294
112Oocyte meiosis_Homo sapiens_hsa041140.54113821
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.53940624
114Epstein-Barr virus infection_Homo sapiens_hsa051690.53934284
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52956492
116Ovarian steroidogenesis_Homo sapiens_hsa049130.52929879
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52192423
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51090308
119Axon guidance_Homo sapiens_hsa043600.49591175
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49287816
121Glutamatergic synapse_Homo sapiens_hsa047240.49075010
122RNA transport_Homo sapiens_hsa030130.47967985
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47532510
124Chemokine signaling pathway_Homo sapiens_hsa040620.44425931
125Systemic lupus erythematosus_Homo sapiens_hsa053220.44195235
126Wnt signaling pathway_Homo sapiens_hsa043100.43849091
127Melanoma_Homo sapiens_hsa052180.43224701
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42331828
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42206484
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.42048400
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41492940
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40867138
133Circadian rhythm_Homo sapiens_hsa047100.39588613
134One carbon pool by folate_Homo sapiens_hsa006700.39068266
135Mineral absorption_Homo sapiens_hsa049780.38523586
136Influenza A_Homo sapiens_hsa051640.38084163
137Ras signaling pathway_Homo sapiens_hsa040140.37558620
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37447819
139Cardiac muscle contraction_Homo sapiens_hsa042600.36585828
140Pathways in cancer_Homo sapiens_hsa052000.35922204
141Prolactin signaling pathway_Homo sapiens_hsa049170.35469953
142Regulation of autophagy_Homo sapiens_hsa041400.35304245
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34476310
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33822905
145Huntingtons disease_Homo sapiens_hsa050160.33703012
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33229044
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32972880
148Phagosome_Homo sapiens_hsa041450.32730228
149cAMP signaling pathway_Homo sapiens_hsa040240.32462925
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.32004115
151Fatty acid elongation_Homo sapiens_hsa000620.30395583
152TNF signaling pathway_Homo sapiens_hsa046680.30163760
153Retinol metabolism_Homo sapiens_hsa008300.29942438
154Leishmaniasis_Homo sapiens_hsa051400.29831270
155Pertussis_Homo sapiens_hsa051330.28828273
156Lysine degradation_Homo sapiens_hsa003100.26646612

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