SURF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.92980506
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.81338640
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.31683229
4ATP synthesis coupled proton transport (GO:0015986)5.31683229
5respiratory electron transport chain (GO:0022904)5.15575496
6electron transport chain (GO:0022900)5.04296023
7chaperone-mediated protein transport (GO:0072321)4.80406671
8fatty acid elongation (GO:0030497)4.54669892
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.36919748
10protein complex biogenesis (GO:0070271)4.21445839
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.12876696
12NADH dehydrogenase complex assembly (GO:0010257)4.12876696
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12876696
14mitochondrial calcium ion transport (GO:0006851)3.98577931
15mitochondrial respiratory chain complex assembly (GO:0033108)3.85682832
16purine ribonucleotide transport (GO:0015868)3.77151066
17positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.71028109
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60643964
19adenine nucleotide transport (GO:0051503)3.52630925
20NADH metabolic process (GO:0006734)3.52485431
21L-phenylalanine catabolic process (GO:0006559)3.50820539
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50820539
23positive regulation of triglyceride lipase activity (GO:0061365)3.46608918
24positive regulation of lipoprotein lipase activity (GO:0051006)3.46608918
25peroxisome fission (GO:0016559)3.40893359
26succinate metabolic process (GO:0006105)3.38839144
27* hydrogen ion transmembrane transport (GO:1902600)3.35010331
28inner mitochondrial membrane organization (GO:0007007)3.34012750
29regulation of oxidative phosphorylation (GO:0002082)3.32992650
30L-phenylalanine metabolic process (GO:0006558)3.31159124
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31159124
32NIK/NF-kappaB signaling (GO:0038061)3.29300683
33deoxyribonucleotide catabolic process (GO:0009264)3.24196837
34protein neddylation (GO:0045116)3.23719976
35mitotic nuclear envelope reassembly (GO:0007084)3.19979843
36nuclear envelope reassembly (GO:0031468)3.19979843
37* respiratory chain complex IV assembly (GO:0008535)3.15815375
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14514341
39ATP hydrolysis coupled proton transport (GO:0015991)3.14514341
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14276630
41purine nucleotide transport (GO:0015865)3.14206745
42* ATP biosynthetic process (GO:0006754)3.11806720
43cellular response to thyroid hormone stimulus (GO:0097067)3.09868845
44aldehyde catabolic process (GO:0046185)3.08882196
45* proton transport (GO:0015992)3.04773166
46sulfur amino acid catabolic process (GO:0000098)3.03414950
47coenzyme catabolic process (GO:0009109)3.02433467
48deoxyribose phosphate catabolic process (GO:0046386)3.02291244
49* hydrogen transport (GO:0006818)3.00910422
50* oxidative phosphorylation (GO:0006119)2.97871699
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94447020
52long-chain fatty acid biosynthetic process (GO:0042759)2.94188026
53viral protein processing (GO:0019082)2.91489055
54oxaloacetate metabolic process (GO:0006107)2.90954105
55mannosylation (GO:0097502)2.90147269
56* purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87382833
57dopamine transport (GO:0015872)2.86621517
58negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86504536
59mitochondrial calcium ion homeostasis (GO:0051560)2.86118840
60* purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84560452
61* cytochrome complex assembly (GO:0017004)2.82919002
62rRNA modification (GO:0000154)2.82656558
63protein maturation by protein folding (GO:0022417)2.80699662
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80659041
65cellular ketone body metabolic process (GO:0046950)2.80474152
66regulation of cellular respiration (GO:0043457)2.79510501
67DNA deamination (GO:0045006)2.78262453
68transferrin transport (GO:0033572)2.78176777
69metallo-sulfur cluster assembly (GO:0031163)2.75595252
70iron-sulfur cluster assembly (GO:0016226)2.75595252
71neutrophil activation involved in immune response (GO:0002283)2.72664308
72nucleoside transport (GO:0015858)2.72412786
73cofactor catabolic process (GO:0051187)2.71122102
74L-methionine salvage (GO:0071267)2.70896264
75L-methionine biosynthetic process (GO:0071265)2.70896264
76amino acid salvage (GO:0043102)2.70896264
77* aerobic respiration (GO:0009060)2.68483426
78axon ensheathment in central nervous system (GO:0032291)2.67379757
79central nervous system myelination (GO:0022010)2.67379757
80aromatic amino acid family catabolic process (GO:0009074)2.67223362
81positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.65730163
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.64261829
83fatty-acyl-CoA metabolic process (GO:0035337)2.64107572
84base-excision repair, AP site formation (GO:0006285)2.63683690
85neuronal action potential propagation (GO:0019227)2.63337690
86xenobiotic catabolic process (GO:0042178)2.63324007
87acyl-CoA biosynthetic process (GO:0071616)2.61098870
88thioester biosynthetic process (GO:0035384)2.61098870
89regulation of mitochondrial translation (GO:0070129)2.60670635
90amino sugar catabolic process (GO:0046348)2.59989012
91synaptic vesicle exocytosis (GO:0016079)2.59520907
92deoxyribose phosphate metabolic process (GO:0019692)2.59039668
93glutathione biosynthetic process (GO:0006750)2.58506001
94presynaptic membrane assembly (GO:0097105)2.57917600
95presynaptic membrane organization (GO:0097090)2.57451160
96proteasome assembly (GO:0043248)2.56594675
97positive regulation of mitochondrial fission (GO:0090141)2.56349612
98ferric iron transport (GO:0015682)2.56263181
99trivalent inorganic cation transport (GO:0072512)2.56263181
100long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.55819916
101NAD metabolic process (GO:0019674)2.55744033
102long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.55531004
103response to thyroid hormone (GO:0097066)2.54959406
104acyl-CoA metabolic process (GO:0006637)2.54845242
105thioester metabolic process (GO:0035383)2.54845242
106neurotransmitter uptake (GO:0001504)2.53501968
107intracellular protein transmembrane import (GO:0044743)2.51265731
108branched-chain amino acid catabolic process (GO:0009083)2.51034573
109guanosine-containing compound biosynthetic process (GO:1901070)2.50447347
110very long-chain fatty acid metabolic process (GO:0000038)2.50197832
111virion assembly (GO:0019068)2.50193291
112purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.50147453
113tricarboxylic acid cycle (GO:0006099)2.49788185
114purine nucleoside diphosphate metabolic process (GO:0009135)2.49460575
115purine ribonucleoside diphosphate metabolic process (GO:0009179)2.49460575
116signal peptide processing (GO:0006465)2.49283287
117* ribonucleoside triphosphate biosynthetic process (GO:0009201)2.48781867
118activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.48314365
119fatty-acyl-CoA biosynthetic process (GO:0046949)2.48242542
120regulation of autophagic vacuole assembly (GO:2000785)2.45951767
121immunoglobulin mediated immune response (GO:0016064)2.42723217
122fat-soluble vitamin biosynthetic process (GO:0042362)2.42675847
123ketone body metabolic process (GO:1902224)2.41655105
124substantia nigra development (GO:0021762)2.41651188
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41208158
126regulation of cellular amino acid metabolic process (GO:0006521)2.40267841
127pyrimidine nucleotide catabolic process (GO:0006244)2.40234336
128regulation of dopamine metabolic process (GO:0042053)2.38566871
129regulation of catecholamine metabolic process (GO:0042069)2.38566871
130phagosome maturation (GO:0090382)2.38284721
131nonribosomal peptide biosynthetic process (GO:0019184)2.38132067
1322-deoxyribonucleotide metabolic process (GO:0009394)2.37779555
133GDP-mannose metabolic process (GO:0019673)2.36901310
134heme metabolic process (GO:0042168)2.36676601
135purine deoxyribonucleotide metabolic process (GO:0009151)2.34993815
136dicarboxylic acid catabolic process (GO:0043649)2.34922677
137bile acid biosynthetic process (GO:0006699)2.34290495
138mitochondrial transport (GO:0006839)2.33660931
139valine metabolic process (GO:0006573)2.33211575
140purine deoxyribonucleotide catabolic process (GO:0009155)2.32744221
141protein deneddylation (GO:0000338)2.30960079
142protein targeting to mitochondrion (GO:0006626)2.30666889
143cholesterol biosynthetic process (GO:0006695)2.30583332
144amyloid precursor protein catabolic process (GO:0042987)2.30121779
145glutathione derivative metabolic process (GO:1901685)2.30043277
146glutathione derivative biosynthetic process (GO:1901687)2.30043277
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.29800199
148response to peptidoglycan (GO:0032494)2.29615756
149deoxyribose phosphate biosynthetic process (GO:0046385)2.29455794
1502-deoxyribonucleotide biosynthetic process (GO:0009265)2.29455794
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.29292664
152pentose metabolic process (GO:0019321)2.29235432
153neuron cell-cell adhesion (GO:0007158)2.28836584
154antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.28826209
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.28300454
156establishment of protein localization to mitochondrion (GO:0072655)2.26725156
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26608981
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.26608981
159positive regulation by organism of defense response of other organism involved in symbiotic interact2.26608981
160modulation by symbiont of host immune response (GO:0052553)2.26608981
161positive regulation by symbiont of host defense response (GO:0052509)2.26608981
162modulation by symbiont of host defense response (GO:0052031)2.26608981
163cullin deneddylation (GO:0010388)2.25926250
164protoporphyrinogen IX biosynthetic process (GO:0006782)2.25480437
165regulation of vacuole organization (GO:0044088)2.25305408
166negative regulation of cell killing (GO:0031342)2.24849591
167negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24849591
168GMP metabolic process (GO:0046037)2.24604721
169glutathione metabolic process (GO:0006749)2.24002830
170glyoxylate metabolic process (GO:0046487)2.20030627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25157730
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13771911
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09475196
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06948462
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.87057470
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77496968
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.63511544
8GBX2_23144817_ChIP-Seq_PC3_Human2.61652923
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58607964
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45809097
11* SRF_21415370_ChIP-Seq_HL-1_Mouse2.37034117
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34972571
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32041094
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30036584
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29729150
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.26543715
17VDR_21846776_ChIP-Seq_THP-1_Human2.24440186
18LXR_22292898_ChIP-Seq_THP-1_Human2.16479811
19TAF15_26573619_Chip-Seq_HEK293_Human2.16361342
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09151761
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01827815
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.98966989
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96409067
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95120829
25* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93274092
26P68_20966046_ChIP-Seq_HELA_Human1.89789482
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88312393
28BCL6_27268052_Chip-Seq_Bcells_Human1.85762792
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85649431
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84125250
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81063442
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.78135788
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78085345
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.76119861
35BCOR_27268052_Chip-Seq_Bcells_Human1.73097109
36GABP_19822575_ChIP-Seq_HepG2_Human1.71149624
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.70430785
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69679443
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.67741492
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.67577759
41MAF_26560356_Chip-Seq_TH2_Human1.65837400
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63590096
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59891961
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55972183
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.55431871
46HTT_18923047_ChIP-ChIP_STHdh_Human1.55072187
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.54475446
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54090039
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54012474
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53898744
51REST_21632747_ChIP-Seq_MESCs_Mouse1.53631811
52EZH2_22144423_ChIP-Seq_EOC_Human1.51177051
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48175358
54CTCF_26484167_Chip-Seq_Bcells_Mouse1.45833185
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44162486
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42110654
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41578402
58PHF8_20622854_ChIP-Seq_HELA_Human1.41278051
59XRN2_22483619_ChIP-Seq_HELA_Human1.39752864
60RACK7_27058665_Chip-Seq_MCF-7_Human1.39224665
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.38761131
62SPI1_23547873_ChIP-Seq_NB4_Human1.38265404
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38210138
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.37856213
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37637415
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37194911
67E2F1_20622854_ChIP-Seq_HELA_Human1.34553020
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34096173
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33566109
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.32714778
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32640795
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.31942803
73SA1_27219007_Chip-Seq_Bcells_Human1.31772365
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29728932
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29628968
76ZNF263_19887448_ChIP-Seq_K562_Human1.29225955
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.27784042
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27677552
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27373978
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26090596
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25310511
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25247727
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25163102
84P300_27268052_Chip-Seq_Bcells_Human1.25023776
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24348943
86MAF_26560356_Chip-Seq_TH1_Human1.23578533
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21161951
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20817158
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20635093
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20510376
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20141240
92SMC4_20622854_ChIP-Seq_HELA_Human1.19753271
93UTX_26944678_Chip-Seq_JUKART_Human1.19281703
94TFEB_21752829_ChIP-Seq_HELA_Human1.18977665
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18261132
96VDR_22108803_ChIP-Seq_LS180_Human1.17765757
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17399199
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15273771
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14503256
100RARB_24833708_ChIP-Seq_LIVER_Mouse1.14184159
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14088830
102VDR_24763502_ChIP-Seq_THP-1_Human1.14016785
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11478780
104CTCF_20526341_ChIP-Seq_ESCs_Human1.11434834
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11387131
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11354255
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10325255
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09597525
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08783501
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08762845
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08530271
112FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07047811
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06742458
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06532845
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06222641
116CTCF_21964334_Chip-Seq_Bcells_Human1.05894295
117* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05661082
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05604418
119IRF1_19129219_ChIP-ChIP_H3396_Human1.05189448
120* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04493321
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04310064
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03700484
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03578035
124RUNX1_22412390_ChIP-Seq_EML_Mouse1.03444859
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02999493
126LXR_22158963_ChIP-Seq_LIVER_Mouse1.02747800
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01988301
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00912265
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98472012
130EZH2_27294783_Chip-Seq_ESCs_Mouse0.98362055
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98323379
132ER_23166858_ChIP-Seq_MCF-7_Human0.98166113
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.96480853
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94255120
135SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93137058
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93040149
137* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93026888
138* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93019693
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.93009550
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92963418
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92784887
142NCOR_22424771_ChIP-Seq_293T_Human0.92767798
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92296776
144EED_16625203_ChIP-ChIP_MESCs_Mouse0.91305810
145NANOG_19829295_ChIP-Seq_ESCs_Human0.91043429
146SOX2_19829295_ChIP-Seq_ESCs_Human0.91043429
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90162010
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89809307
149PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89585641
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89278078
151EOMES_21245162_ChIP-Seq_HESCs_Human0.88981449
152DCP1A_22483619_ChIP-Seq_HELA_Human0.88867650
153P300_19829295_ChIP-Seq_ESCs_Human0.88744839
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88442772
155VDR_23849224_ChIP-Seq_CD4+_Human0.87211525
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83323877
157* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82426495
158RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81584210
159PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80962291
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80750627
161RARB_27405468_Chip-Seq_BRAIN_Mouse0.79753844
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78156343
163EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77659158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.31958939
2MP0003880_abnormal_central_pattern3.76106585
3MP0003806_abnormal_nucleotide_metabolis3.10621165
4MP0001529_abnormal_vocalization2.73024308
5MP0004142_abnormal_muscle_tone2.68177868
6MP0002139_abnormal_hepatobiliary_system2.64270917
7MP0005360_urolithiasis2.58284056
8MP0002736_abnormal_nociception_after2.45247914
9MP0004043_abnormal_pH_regulation2.42644208
10MP0002272_abnormal_nervous_system2.39407765
11MP0003436_decreased_susceptibility_to2.35748890
12MP0001968_abnormal_touch/_nociception2.35576371
13MP0002064_seizures2.30514449
14MP0002837_dystrophic_cardiac_calcinosis2.29069021
15* MP0006036_abnormal_mitochondrial_physio2.27110718
16MP0002822_catalepsy2.25314309
17MP0006082_CNS_inflammation2.21210768
18MP0004859_abnormal_synaptic_plasticity2.11544401
19MP0001905_abnormal_dopamine_level2.11474677
20MP0009745_abnormal_behavioral_response2.09138793
21MP0009046_muscle_twitch2.08612268
22MP0008875_abnormal_xenobiotic_pharmacok2.05812359
23MP0003635_abnormal_synaptic_transmissio2.00738843
24MP0005085_abnormal_gallbladder_physiolo1.98183889
25MP0000013_abnormal_adipose_tissue1.97679793
26MP0002148_abnormal_hypersensitivity_rea1.95539534
27MP0002876_abnormal_thyroid_physiology1.94635313
28MP0006276_abnormal_autonomic_nervous1.92579064
29MP0006035_abnormal_mitochondrial_morpho1.90391328
30MP0005025_abnormal_response_to1.89154445
31MP0009785_altered_susceptibility_to1.85808972
32MP0005365_abnormal_bile_salt1.84792700
33MP0009333_abnormal_splenocyte_physiolog1.80479443
34MP0001835_abnormal_antigen_presentation1.79333245
35MP0002735_abnormal_chemical_nociception1.77602527
36MP0002572_abnormal_emotion/affect_behav1.76076241
37MP0003195_calcinosis1.75020534
38MP0003879_abnormal_hair_cell1.73636832
39MP0005000_abnormal_immune_tolerance1.72943282
40MP0002734_abnormal_mechanical_nocicepti1.71005693
41MP0001440_abnormal_grooming_behavior1.70919612
42MP0001986_abnormal_taste_sensitivity1.70016131
43MP0005671_abnormal_response_to1.67176466
44MP0001486_abnormal_startle_reflex1.64957256
45MP0002638_abnormal_pupillary_reflex1.64221665
46MP0001764_abnormal_homeostasis1.63108688
47MP0002254_reproductive_system_inflammat1.62522422
48MP0003329_amyloid_beta_deposits1.61921202
49MP0002163_abnormal_gland_morphology1.60698455
50MP0004270_analgesia1.60466212
51MP0001970_abnormal_pain_threshold1.60402101
52MP0002063_abnormal_learning/memory/cond1.59882192
53MP0000685_abnormal_immune_system1.58824336
54MP0005332_abnormal_amino_acid1.58663931
55MP0008469_abnormal_protein_level1.58155019
56MP0002419_abnormal_innate_immunity1.56935712
57MP0005423_abnormal_somatic_nervous1.56190013
58MP0005387_immune_system_phenotype1.55617497
59MP0001790_abnormal_immune_system1.55617497
60MP0000920_abnormal_myelination1.54622571
61MP0009379_abnormal_foot_pigmentation1.52061742
62MP0010386_abnormal_urinary_bladder1.50868342
63MP0002723_abnormal_immune_serum1.50187660
64MP0001845_abnormal_inflammatory_respons1.47839558
65MP0002067_abnormal_sensory_capabilities1.45421535
66MP0002733_abnormal_thermal_nociception1.44936176
67MP0010155_abnormal_intestine_physiology1.44154906
68MP0004147_increased_porphyrin_level1.42984018
69MP0003303_peritoneal_inflammation1.40970798
70MP0002693_abnormal_pancreas_physiology1.39244604
71MP0010329_abnormal_lipoprotein_level1.38881619
72MP0001984_abnormal_olfaction1.38639246
73MP0002653_abnormal_ependyma_morphology1.38438471
74MP0008260_abnormal_autophagy1.38264792
75MP0003724_increased_susceptibility_to1.36253803
76MP0001800_abnormal_humoral_immune1.35955318
77MP0001501_abnormal_sleep_pattern1.35344610
78MP0005464_abnormal_platelet_physiology1.34668687
79MP0003011_delayed_dark_adaptation1.33728345
80MP0005535_abnormal_body_temperature1.32253619
81MP0001502_abnormal_circadian_rhythm1.32225870
82MP0005083_abnormal_biliary_tract1.31451313
83MP0002420_abnormal_adaptive_immunity1.30628398
84MP0001819_abnormal_immune_cell1.29775736
85MP0005075_abnormal_melanosome_morpholog1.28972245
86MP0004510_myositis1.28015592
87MP0003075_altered_response_to1.27307107
88MP0002452_abnormal_antigen_presenting1.25096867
89MP0003191_abnormal_cellular_cholesterol1.24224089
90MP0003690_abnormal_glial_cell1.23701025
91MP0008872_abnormal_physiological_respon1.23589128
92MP0004924_abnormal_behavior1.23420667
93MP0005386_behavior/neurological_phenoty1.23420667
94MP0008569_lethality_at_weaning1.22254004
95MP0005397_hematopoietic_system_phenotyp1.21756421
96MP0001545_abnormal_hematopoietic_system1.21756421
97MP0005646_abnormal_pituitary_gland1.18759088
98MP0002229_neurodegeneration1.17563930
99MP0005084_abnormal_gallbladder_morpholo1.16402277
100MP0003186_abnormal_redox_activity1.15879755
101MP0000343_altered_response_to1.15314807
102MP0001666_abnormal_nutrient_absorption1.13273808
103MP0005636_abnormal_mineral_homeostasis1.13265019
104MP0000609_abnormal_liver_physiology1.09985601
105* MP0005584_abnormal_enzyme/coenzyme_acti1.08395989
106MP0001873_stomach_inflammation1.07777871
107MP0002909_abnormal_adrenal_gland1.07564597
108MP0003787_abnormal_imprinting1.07097008
109MP0002118_abnormal_lipid_homeostasis1.04480996
110MP0005058_abnormal_lysosome_morphology1.03834230
111MP0001188_hyperpigmentation1.03665829
112MP0002277_abnormal_respiratory_mucosa1.03087106
113MP0001533_abnormal_skeleton_physiology1.02526610
114MP0001944_abnormal_pancreas_morphology1.01570452
115MP0010234_abnormal_vibrissa_follicle1.01304896
116MP0003656_abnormal_erythrocyte_physiolo1.00914045
117MP0004947_skin_inflammation1.00489691
118MP0000716_abnormal_immune_system1.00001472
119MP0005551_abnormal_eye_electrophysiolog0.98892311
120MP0005451_abnormal_body_composition0.98120871
121MP0009764_decreased_sensitivity_to0.96603424
122MP0000230_abnormal_systemic_arterial0.96030007
123* MP0002066_abnormal_motor_capabilities/c0.95489515
124MP0000689_abnormal_spleen_morphology0.94945013
125MP0000604_amyloidosis0.94541299
126MP0003866_abnormal_defecation0.89985729
127MP0004185_abnormal_adipocyte_glucose0.89771070
128MP0002722_abnormal_immune_system0.86161841
129MP0000747_muscle_weakness0.86055222
130MP0001664_abnormal_digestion0.85676419
131MP0003633_abnormal_nervous_system0.85663127
132MP0009642_abnormal_blood_homeostasis0.83286186
133MP0001756_abnormal_urination0.83275479
134MP0005376_homeostasis/metabolism_phenot0.83179607
135MP0004742_abnormal_vestibular_system0.82399997
136MP0002429_abnormal_blood_cell0.82278170
137MP0002090_abnormal_vision0.81461585
138MP0000015_abnormal_ear_pigmentation0.80800703
139MP0009840_abnormal_foam_cell0.80747740
140MP0002557_abnormal_social/conspecific_i0.79867500
141MP0002405_respiratory_system_inflammati0.79622393
142MP0003172_abnormal_lysosome_physiology0.79307902
143MP0009643_abnormal_urine_homeostasis0.79208004
144MP0000490_abnormal_crypts_of0.78812341
145MP0002398_abnormal_bone_marrow0.78573686
146MP0005645_abnormal_hypothalamus_physiol0.78316506
147MP0005379_endocrine/exocrine_gland_phen0.77185530
148MP0003646_muscle_fatigue0.77170849
149MP0005319_abnormal_enzyme/_coenzyme0.76599098
150MP0004019_abnormal_vitamin_homeostasis0.74776592
151MP0003634_abnormal_glial_cell0.74690480
152MP0009780_abnormal_chondrocyte_physiolo0.74638336
153MP0001663_abnormal_digestive_system0.73811221
154MP0001765_abnormal_ion_homeostasis0.73171704
155MP0003183_abnormal_peptide_metabolism0.72488748
156MP0000358_abnormal_cell_content/0.71858717
157MP0002078_abnormal_glucose_homeostasis0.70548663
158MP0004036_abnormal_muscle_relaxation0.70265664
159MP0003631_nervous_system_phenotype0.70258685
160* MP0008874_decreased_physiological_sensi0.70211219
161MP0001963_abnormal_hearing_physiology0.69941749

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.63319487
2Abnormal mitochondria in muscle tissue (HP:0008316)5.29000875
3Petechiae (HP:0000967)5.22206161
4Acute encephalopathy (HP:0006846)5.07852129
5* Mitochondrial inheritance (HP:0001427)4.96446220
6* Hepatocellular necrosis (HP:0001404)4.85659101
7Progressive macrocephaly (HP:0004481)4.65288097
8* Hepatic necrosis (HP:0002605)4.40612716
9* Increased CSF lactate (HP:0002490)4.34426758
10Cerebral edema (HP:0002181)3.95425786
11Abnormality of glycolysis (HP:0004366)3.48388289
12Increased serum pyruvate (HP:0003542)3.48388289
13Increased hepatocellular lipid droplets (HP:0006565)3.43695394
14Renal Fanconi syndrome (HP:0001994)3.41805954
15Lipid accumulation in hepatocytes (HP:0006561)3.39692671
16* Lactic acidosis (HP:0003128)3.37076866
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.28849846
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.28849846
19Leukodystrophy (HP:0002415)3.28159616
20Vacuolated lymphocytes (HP:0001922)3.26114850
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.19112649
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18850796
23Increased intramyocellular lipid droplets (HP:0012240)3.14347646
24Abnormality of macrophages (HP:0004311)3.09897085
25* Respiratory failure (HP:0002878)3.06566205
26Dysostosis multiplex (HP:0000943)3.06167827
27Focal motor seizures (HP:0011153)3.02505448
28Pheochromocytoma (HP:0002666)3.01144846
29* Increased serum lactate (HP:0002151)3.00668540
30Increased muscle lipid content (HP:0009058)2.96911643
31Abnormality of glycolipid metabolism (HP:0010969)2.96794966
32Abnormality of liposaccharide metabolism (HP:0010968)2.96794966
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.96794966
34Neuroendocrine neoplasm (HP:0100634)2.96231069
35Optic disc pallor (HP:0000543)2.94674509
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91169368
373-Methylglutaconic aciduria (HP:0003535)2.82431490
38Myokymia (HP:0002411)2.81565310
39Lethargy (HP:0001254)2.74058085
40Exercise intolerance (HP:0003546)2.72884335
41Increased cerebral lipofuscin (HP:0011813)2.71715332
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.62143007
43Abnormality of polysaccharide metabolism (HP:0011012)2.61599990
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61599990
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61599990
46Limb dystonia (HP:0002451)2.59127460
47Generalized aminoaciduria (HP:0002909)2.55695733
48Methylmalonic acidemia (HP:0002912)2.55283817
49Mucopolysacchariduria (HP:0008155)2.55143828
50Urinary glycosaminoglycan excretion (HP:0003541)2.55143828
51* CNS demyelination (HP:0007305)2.52519493
52Increased serum ferritin (HP:0003281)2.47469083
53Abnormality of dental color (HP:0011073)2.47368834
54Short middle phalanx of the 5th finger (HP:0004220)2.46204005
55Methylmalonic aciduria (HP:0012120)2.44929513
56Eczematoid dermatitis (HP:0000976)2.43093177
57Systemic lupus erythematosus (HP:0002725)2.40762922
58Prolonged neonatal jaundice (HP:0006579)2.40602148
59Loss of speech (HP:0002371)2.39007709
60Dicarboxylic aciduria (HP:0003215)2.36556488
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36556488
62Progressive neurologic deterioration (HP:0002344)2.35240977
63Acanthocytosis (HP:0001927)2.34965224
64Elevated erythrocyte sedimentation rate (HP:0003565)2.31633399
65Cerebral hemorrhage (HP:0001342)2.31246291
66Atonic seizures (HP:0010819)2.31096053
67Testicular atrophy (HP:0000029)2.30687321
68Xanthomatosis (HP:0000991)2.30093271
69Hypobetalipoproteinemia (HP:0003563)2.29896545
70Prolonged partial thromboplastin time (HP:0003645)2.26484762
71Hypothermia (HP:0002045)2.26129951
72Brushfield spots (HP:0001088)2.24328800
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.23738350
74Abnormality of renal resorption (HP:0011038)2.23047710
75Failure to thrive in infancy (HP:0001531)2.22851153
76Recurrent abscess formation (HP:0002722)2.22198513
77Recurrent bacterial skin infections (HP:0005406)2.19279062
78Abnormality of iron homeostasis (HP:0011031)2.19247449
79Vomiting (HP:0002013)2.17721724
80Abnormality of fatty-acid metabolism (HP:0004359)2.16958656
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16892472
82Hyperventilation (HP:0002883)2.16030423
83Congenital malformation of the right heart (HP:0011723)2.14075081
84Double outlet right ventricle (HP:0001719)2.14075081
85Intrahepatic cholestasis (HP:0001406)2.12445453
86Progressive inability to walk (HP:0002505)2.10323436
87Conjugated hyperbilirubinemia (HP:0002908)2.10275449
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09141419
89Hyperinsulinemic hypoglycemia (HP:0000825)2.08613973
90Abnormality of urine glucose concentration (HP:0011016)2.07776599
91Glycosuria (HP:0003076)2.07776599
92Exertional dyspnea (HP:0002875)2.07654212
93Tongue fasciculations (HP:0001308)2.06380614
94Obstructive lung disease (HP:0006536)2.05811730
95Chronic obstructive pulmonary disease (HP:0006510)2.05811730
96Purpura (HP:0000979)2.04836580
97* Emotional lability (HP:0000712)2.04031188
98Prolonged bleeding time (HP:0003010)2.03869327
99Ketosis (HP:0001946)2.03392526
100Respiratory difficulties (HP:0002880)2.02283345
101Poor suck (HP:0002033)2.01503587
102Hyperglycinemia (HP:0002154)2.00771924
103X-linked dominant inheritance (HP:0001423)1.98446141
104Retinal dysplasia (HP:0007973)1.98111194
105Opisthotonus (HP:0002179)1.97529715
106Abnormal number of erythroid precursors (HP:0012131)1.97484360
107Abnormality of cells of the erythroid lineage (HP:0012130)1.96752636
108Cholecystitis (HP:0001082)1.96516277
109Abnormal gallbladder physiology (HP:0012438)1.96516277
110Abnormal protein glycosylation (HP:0012346)1.96196485
111Abnormal glycosylation (HP:0012345)1.96196485
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96196485
113Abnormal protein N-linked glycosylation (HP:0012347)1.96196485
114Microvesicular hepatic steatosis (HP:0001414)1.93212044
115Cerebral hypomyelination (HP:0006808)1.93135495
116Muscle fibrillation (HP:0010546)1.93048242
117Cerebral palsy (HP:0100021)1.92638263
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91151624
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.91151624
120Focal dystonia (HP:0004373)1.90880507
121Ragged-red muscle fibers (HP:0003200)1.89360617
122Spastic paraparesis (HP:0002313)1.88101072
123Type I transferrin isoform profile (HP:0003642)1.88092184
124Reticulocytosis (HP:0001923)1.87932642
125Hypokinesia (HP:0002375)1.86452297
126Hyperammonemia (HP:0001987)1.85850384
127Hepatosplenomegaly (HP:0001433)1.85222011
128J-shaped sella turcica (HP:0002680)1.84755203
129* Gliosis (HP:0002171)1.83586181
130Absence seizures (HP:0002121)1.83507956
131Abnormality of alanine metabolism (HP:0010916)1.83483259
132Hyperalaninemia (HP:0003348)1.83483259
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83483259
134Abnormality of glycine metabolism (HP:0010895)1.82784310
135Abnormality of serine family amino acid metabolism (HP:0010894)1.82784310
136Abnormal pupillary function (HP:0007686)1.81050262
137Hyperphosphaturia (HP:0003109)1.80805012
138Metabolic acidosis (HP:0001942)1.80667575
139Hyperthyroidism (HP:0000836)1.79884453
140Stomatitis (HP:0010280)1.79763531
141Hyperlipoproteinemia (HP:0010980)1.79465026
142Epileptic encephalopathy (HP:0200134)1.79261072
143Medial flaring of the eyebrow (HP:0010747)1.78739577
144Myositis (HP:0100614)1.78445036
145Neurofibrillary tangles (HP:0002185)1.77452820
146Abnormality of transition element cation homeostasis (HP:0011030)1.76521354
147Parakeratosis (HP:0001036)1.75911335
148Impaired platelet aggregation (HP:0003540)1.75082922
149Abnormal platelet function (HP:0011869)1.75082922
150Deep palmar crease (HP:0006191)1.74905563
151Recurrent gram-negative bacterial infections (HP:0005420)1.74429792
152Abnormal hair whorl (HP:0010721)1.73071084
153Polyphagia (HP:0002591)1.72969675
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72657709
155Dialeptic seizures (HP:0011146)1.72654585
156Oligomenorrhea (HP:0000876)1.72124977
157Anxiety (HP:0000739)1.70919555
158Gait imbalance (HP:0002141)1.69863281
159Epiphyseal stippling (HP:0010655)1.69626922
160Gout (HP:0001997)1.67925124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.47876231
2MAP3K123.98825204
3ARAF3.66290560
4CASK3.27845601
5STK162.69324877
6TESK12.64684788
7CDK192.50086770
8OXSR12.38801712
9BRAF2.33018686
10VRK22.26230624
11MYLK2.25398874
12BCKDK2.04975086
13STK391.97543254
14PRPF4B1.95636244
15MAP2K71.94692658
16TNIK1.94063457
17TBK11.88340779
18MAP4K11.83526910
19EPHA41.81714356
20BMPR1B1.80331583
21NME11.77467576
22MST41.72519707
23TYK21.69835334
24IRAK31.68500543
25AKT31.56889205
26PIM21.56788409
27MAPKAPK51.48932632
28IRAK41.46801138
29GRK51.43365097
30TRIB31.41341822
31BLK1.40236166
32PINK11.39412396
33MAP2K41.38775199
34TAOK21.37374024
35TAOK11.36452170
36MAP3K41.34064850
37SIK21.32825261
38EPHB11.31896610
39ZAP701.31378217
40GRK71.30053246
41GRK61.28092615
42PIK3CA1.27667644
43MAPKAPK31.25708699
44NTRK31.24735556
45MAP3K11.24031404
46CAMK2B1.23933628
47KDR1.20028528
48DAPK21.19029574
49MAP2K31.18610864
50NME21.16762500
51SIK11.15755923
52CAMK2G1.14284646
53LRRK21.12969592
54IKBKB1.12883590
55MUSK1.12783542
56ADRBK21.12448163
57MAP3K91.11222067
58SIK31.09881420
59PDK21.09631851
60LIMK11.09418490
61PHKG21.06173934
62PHKG11.06173934
63DAPK11.05453884
64DAPK31.04649809
65WNK41.01748560
66NEK61.00816452
67MAP3K31.00132092
68BMPR20.95073205
69GRK10.94603872
70VRK10.93115311
71CAMK2D0.92730781
72PRKCI0.91093688
73BCR0.90287718
74CSNK1G30.89165308
75SMG10.88524322
76CAMK2A0.88264542
77ABL20.87136446
78IKBKE0.86353884
79EIF2AK30.85883402
80TLK10.85384719
81MINK10.82900273
82CDK50.81767645
83MAPK130.81473208
84SGK4940.79032840
85SGK2230.79032840
86SRPK10.78603594
87PRKCG0.78388198
88PRKD30.77690042
89RIPK40.77472902
90PDPK10.77324292
91TESK20.77265201
92TXK0.77178442
93MAP4K20.73439620
94PLK20.72533268
95TSSK60.71475974
96CAMKK20.71070709
97KIT0.70620256
98MAP3K130.70241738
99CSK0.68735921
100MAP2K60.68543661
101CCNB10.68296769
102CSNK1G20.65683515
103PDK30.65613053
104PDK40.65613053
105LYN0.63275412
106CDK180.62573418
107RAF10.62506879
108ADRBK10.62487703
109CDK11A0.62086783
110CDK150.61058753
111TNK20.60785727
112TEC0.60551432
113PRKCE0.60183258
114CDK140.59897451
115ZAK0.57945731
116PRKD20.57393719
117DYRK30.56918534
118MAPK120.55635423
119MATK0.53122190
120PRKACA0.52352553
121ILK0.51845701
122PDK10.50880420
123PAK40.50698667
124FES0.50347126
125SYK0.49483138
126EIF2AK10.48553536
127UHMK10.48209992
128ROCK20.47655265
129STK240.47077617
130PRKD10.46874192
131NTRK10.45992569
132PKN20.44957727
133CSNK1G10.44829849
134BTK0.44476004
135AURKA0.44131294
136FGR0.43783219
137EPHA20.43583232
138PKN10.42545257
139MAP3K110.41522584
140OBSCN0.40994999
141LCK0.40340694
142PASK0.40187541
143HIPK20.39678595
144MARK20.39572710
145PRKCA0.39542964
146PNCK0.39507183
147PRKCD0.38619933
148NEK90.38357402
149PRKCQ0.38352401
150CDK80.38348826
151IRAK20.38287123
152MAPK110.35884785
153DYRK1B0.34067477
154CAMK10.33333241
155CSNK1A1L0.33209784
156ITK0.32564076
157BMX0.31342258
158PAK10.31327978

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67856338
2Parkinsons disease_Homo sapiens_hsa050123.78512680
3Alzheimers disease_Homo sapiens_hsa050102.84698875
4Other glycan degradation_Homo sapiens_hsa005112.67792312
5Fatty acid elongation_Homo sapiens_hsa000622.66027271
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.51437789
7Sulfur metabolism_Homo sapiens_hsa009202.39857780
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34560441
9Collecting duct acid secretion_Homo sapiens_hsa049662.34276999
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29597481
11Huntingtons disease_Homo sapiens_hsa050162.26195528
12Proteasome_Homo sapiens_hsa030502.13078859
13Protein export_Homo sapiens_hsa030602.08730327
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05972411
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97377992
16Lysosome_Homo sapiens_hsa041421.97224745
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96143629
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86049887
19Pyruvate metabolism_Homo sapiens_hsa006201.80151838
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75669930
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74893367
22Butanoate metabolism_Homo sapiens_hsa006501.72119596
23Synaptic vesicle cycle_Homo sapiens_hsa047211.71705174
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65828709
25Propanoate metabolism_Homo sapiens_hsa006401.65790684
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.64912379
27Nicotine addiction_Homo sapiens_hsa050331.57684041
28Cardiac muscle contraction_Homo sapiens_hsa042601.55574715
29Peroxisome_Homo sapiens_hsa041461.52864654
30Ribosome_Homo sapiens_hsa030101.51466609
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42685873
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40150017
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40098297
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38296179
35Vibrio cholerae infection_Homo sapiens_hsa051101.34417237
36Histidine metabolism_Homo sapiens_hsa003401.32680924
37Fatty acid degradation_Homo sapiens_hsa000711.32229409
38Steroid biosynthesis_Homo sapiens_hsa001001.28186143
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27728056
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25949122
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22324918
42Galactose metabolism_Homo sapiens_hsa000521.21457944
43Fatty acid metabolism_Homo sapiens_hsa012121.19267411
44Primary immunodeficiency_Homo sapiens_hsa053401.18971634
45beta-Alanine metabolism_Homo sapiens_hsa004101.13005476
46Vitamin B6 metabolism_Homo sapiens_hsa007501.11579366
47Carbon metabolism_Homo sapiens_hsa012001.10835741
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10061211
49Type I diabetes mellitus_Homo sapiens_hsa049401.08307887
50RNA polymerase_Homo sapiens_hsa030201.04335234
51Staphylococcus aureus infection_Homo sapiens_hsa051501.03089444
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02354283
53Tyrosine metabolism_Homo sapiens_hsa003501.00201288
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99352292
55Chemical carcinogenesis_Homo sapiens_hsa052040.97381554
56GABAergic synapse_Homo sapiens_hsa047270.97131413
57Phenylalanine metabolism_Homo sapiens_hsa003600.96334416
58Autoimmune thyroid disease_Homo sapiens_hsa053200.95756577
59Tryptophan metabolism_Homo sapiens_hsa003800.95235632
60Metabolic pathways_Homo sapiens_hsa011000.94996213
61Allograft rejection_Homo sapiens_hsa053300.91862398
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.90399848
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86781255
64Folate biosynthesis_Homo sapiens_hsa007900.86662386
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86121177
66Arginine biosynthesis_Homo sapiens_hsa002200.84401617
67Fat digestion and absorption_Homo sapiens_hsa049750.82297538
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81343436
69Graft-versus-host disease_Homo sapiens_hsa053320.79273791
70Salmonella infection_Homo sapiens_hsa051320.78384905
71Glutathione metabolism_Homo sapiens_hsa004800.78079717
72Sulfur relay system_Homo sapiens_hsa041220.77989687
73Rheumatoid arthritis_Homo sapiens_hsa053230.77463942
74Arginine and proline metabolism_Homo sapiens_hsa003300.77070807
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.74694253
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72678810
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72121934
78Regulation of autophagy_Homo sapiens_hsa041400.71781923
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67561375
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66543772
81Legionellosis_Homo sapiens_hsa051340.66355320
82Morphine addiction_Homo sapiens_hsa050320.66066064
83Mineral absorption_Homo sapiens_hsa049780.64138546
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.63607071
85Base excision repair_Homo sapiens_hsa034100.61520510
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60308978
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60229515
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59757882
89Biosynthesis of amino acids_Homo sapiens_hsa012300.58787412
90Olfactory transduction_Homo sapiens_hsa047400.56564512
91Antigen processing and presentation_Homo sapiens_hsa046120.56315659
92Tuberculosis_Homo sapiens_hsa051520.55686850
93Osteoclast differentiation_Homo sapiens_hsa043800.55188561
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.53019836
95Retinol metabolism_Homo sapiens_hsa008300.52978569
96Pentose phosphate pathway_Homo sapiens_hsa000300.52577808
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52133038
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.51777224
99Glycerolipid metabolism_Homo sapiens_hsa005610.50904454
100Shigellosis_Homo sapiens_hsa051310.50750897
101Fructose and mannose metabolism_Homo sapiens_hsa000510.50119693
102Ether lipid metabolism_Homo sapiens_hsa005650.49092922
103Circadian entrainment_Homo sapiens_hsa047130.47996913
104Glutamatergic synapse_Homo sapiens_hsa047240.47784025
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47618766
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47491799
107Serotonergic synapse_Homo sapiens_hsa047260.47435911
108PPAR signaling pathway_Homo sapiens_hsa033200.46248825
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.46001912
110N-Glycan biosynthesis_Homo sapiens_hsa005100.45750629
111Taste transduction_Homo sapiens_hsa047420.44896743
112Complement and coagulation cascades_Homo sapiens_hsa046100.44185846
113Arachidonic acid metabolism_Homo sapiens_hsa005900.43659658
114Asthma_Homo sapiens_hsa053100.43418506
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43262728
116ABC transporters_Homo sapiens_hsa020100.43229222
117Linoleic acid metabolism_Homo sapiens_hsa005910.43033696
118Starch and sucrose metabolism_Homo sapiens_hsa005000.43017730
119Sphingolipid metabolism_Homo sapiens_hsa006000.42781079
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42294127
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41997374
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40275527
123Amphetamine addiction_Homo sapiens_hsa050310.39318126
124Phagosome_Homo sapiens_hsa041450.36531804
125Caffeine metabolism_Homo sapiens_hsa002320.34799927
126Insulin secretion_Homo sapiens_hsa049110.34624664
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32546637
128Salivary secretion_Homo sapiens_hsa049700.31772880
129Pyrimidine metabolism_Homo sapiens_hsa002400.30941212

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