SURF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.13091367
2Golgi transport vesicle coating (GO:0048200)9.13091367
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.75155806
4protein retention in ER lumen (GO:0006621)6.10881828
5COPII vesicle coating (GO:0048208)5.92259508
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.07682149
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.03383297
8positive regulation of nuclease activity (GO:0032075)4.90757861
9regulation of nuclease activity (GO:0032069)4.48724551
10endoplasmic reticulum unfolded protein response (GO:0030968)4.47462648
114-hydroxyproline metabolic process (GO:0019471)4.40083541
12cellular response to unfolded protein (GO:0034620)4.33082894
13signal peptide processing (GO:0006465)4.27900641
14protein maturation by protein folding (GO:0022417)4.19841685
15cellular response to topologically incorrect protein (GO:0035967)4.15864901
16ER-nucleus signaling pathway (GO:0006984)4.14144560
17vesicle coating (GO:0006901)4.05080252
18protein localization to endosome (GO:0036010)3.97320714
19sequestering of metal ion (GO:0051238)3.94863599
20exocrine pancreas development (GO:0031017)3.91059818
21ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.87752528
22basement membrane organization (GO:0071711)3.85861330
23cell adhesion mediated by integrin (GO:0033627)3.80242881
24endocrine pancreas development (GO:0031018)3.62815630
25intestinal cholesterol absorption (GO:0030299)3.53168154
26response to endoplasmic reticulum stress (GO:0034976)3.52224994
27hemidesmosome assembly (GO:0031581)3.50888543
28peptide hormone processing (GO:0016486)3.41117257
29protein N-linked glycosylation via asparagine (GO:0018279)3.35277959
30peptidyl-asparagine modification (GO:0018196)3.34850034
31response to unfolded protein (GO:0006986)3.34681689
32low-density lipoprotein particle clearance (GO:0034383)3.32819654
33cell-substrate junction assembly (GO:0007044)3.31352463
34intestinal absorption (GO:0050892)3.31276859
35endodermal cell differentiation (GO:0035987)3.30122728
36peptidyl-glutamic acid carboxylation (GO:0017187)3.29619485
37protein carboxylation (GO:0018214)3.29619485
38UDP-N-acetylglucosamine metabolic process (GO:0006047)3.29443903
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26140743
40L-phenylalanine metabolic process (GO:0006558)3.26140743
41desmosome organization (GO:0002934)3.26124615
42response to topologically incorrect protein (GO:0035966)3.25834285
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25728287
44L-phenylalanine catabolic process (GO:0006559)3.25728287
45folic acid-containing compound biosynthetic process (GO:0009396)3.25014205
46L-alpha-amino acid transmembrane transport (GO:1902475)3.24755420
47pinocytosis (GO:0006907)3.20366905
48barbed-end actin filament capping (GO:0051016)3.16477167
49tricarboxylic acid metabolic process (GO:0072350)3.06840865
50type B pancreatic cell development (GO:0003323)3.06801043
51protein N-linked glycosylation (GO:0006487)3.05284718
52regulation of cholesterol homeostasis (GO:2000188)3.05228529
53regulation of early endosome to late endosome transport (GO:2000641)3.04557212
54regulation of extracellular matrix disassembly (GO:0010715)3.03796238
55cellular response to vitamin D (GO:0071305)3.03670289
56alpha-linolenic acid metabolic process (GO:0036109)3.02694847
57proline metabolic process (GO:0006560)3.01147843
58valine metabolic process (GO:0006573)3.00579042
59negative regulation of fibrinolysis (GO:0051918)3.00547833
60negative regulation of fatty acid transport (GO:2000192)2.99958265
61adherens junction assembly (GO:0034333)2.99164773
62regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.97495029
63focal adhesion assembly (GO:0048041)2.95402430
64cell-substrate adherens junction assembly (GO:0007045)2.95402430
65apoptotic cell clearance (GO:0043277)2.94871393
66regulation of plasminogen activation (GO:0010755)2.93879760
67epithelial cell-cell adhesion (GO:0090136)2.92985312
68regulation of type B pancreatic cell apoptotic process (GO:2000674)2.92304122
69sulfur amino acid catabolic process (GO:0000098)2.91904284
70hyaluronan catabolic process (GO:0030214)2.90368518
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89276033
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89276033
73ER to Golgi vesicle-mediated transport (GO:0006888)2.88363837
74positive regulation of endothelial cell apoptotic process (GO:2000353)2.87944945
75proline biosynthetic process (GO:0006561)2.80205364
76protein autoprocessing (GO:0016540)2.78159728
77peptide catabolic process (GO:0043171)2.77117270
78peptidyl-proline hydroxylation (GO:0019511)2.75193076
79very-low-density lipoprotein particle assembly (GO:0034379)2.75166248
80glandular epithelial cell development (GO:0002068)2.74881282
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74100626
82glucose 6-phosphate metabolic process (GO:0051156)2.72369639
83membrane protein ectodomain proteolysis (GO:0006509)2.72143467
84lysine metabolic process (GO:0006553)2.72080749
85lysine catabolic process (GO:0006554)2.72080749
86positive regulation of fatty acid biosynthetic process (GO:0045723)2.72040639
87skin morphogenesis (GO:0043589)2.70572361
88embryonic process involved in female pregnancy (GO:0060136)2.69984737
89triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.68976871
90keratan sulfate catabolic process (GO:0042340)2.67869227
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66693742
92adhesion of symbiont to host (GO:0044406)2.66106577
93glucose catabolic process (GO:0006007)2.65428030
94lipoprotein metabolic process (GO:0042157)2.65117199
95cysteine metabolic process (GO:0006534)2.64782562
96positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.63429902
97glutamine family amino acid biosynthetic process (GO:0009084)2.63358935
98stress fiber assembly (GO:0043149)2.63030913
99NADH metabolic process (GO:0006734)2.62484413
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62371387
101positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60831875
102regulation of metalloenzyme activity (GO:0048552)2.60226287
103positive regulation of extracellular matrix organization (GO:1903055)2.59550532
104plasma lipoprotein particle clearance (GO:0034381)2.59422871
105cellular response to vitamin (GO:0071295)2.59388100
106regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.57310298
107positive regulation of glycolytic process (GO:0045821)2.57182345
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.56284418
109regulation of cholesterol biosynthetic process (GO:0045540)2.55287548
110GDP-mannose metabolic process (GO:0019673)2.54970022
111maternal placenta development (GO:0001893)2.54809601
112cellular zinc ion homeostasis (GO:0006882)2.54737658
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53956400
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51000296
115pentose-phosphate shunt (GO:0006098)2.50845134
116regulation of transforming growth factor beta1 production (GO:0032908)2.49220810
117complement activation, alternative pathway (GO:0006957)2.48417231
118collagen fibril organization (GO:0030199)2.47523281
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.47094253
120regulation of mammary gland epithelial cell proliferation (GO:0033599)2.46440074
121protein hydroxylation (GO:0018126)2.46435258
122regulation of fibrinolysis (GO:0051917)2.45580468
123macroautophagy (GO:0016236)2.45543130
124cellular response to nutrient (GO:0031670)2.45335872
125high-density lipoprotein particle remodeling (GO:0034375)2.44680762
126branching involved in mammary gland duct morphogenesis (GO:0060444)2.44662966
127negative regulation of cell size (GO:0045792)2.44208926
128glandular epithelial cell differentiation (GO:0002067)2.43784307
129nitrogen cycle metabolic process (GO:0071941)2.42214899
130pteridine-containing compound biosynthetic process (GO:0042559)2.41889292
131antigen processing and presentation of endogenous antigen (GO:0019883)2.41860448
132hormone catabolic process (GO:0042447)2.41210475
133positive regulation of triglyceride metabolic process (GO:0090208)2.40959356
134reverse cholesterol transport (GO:0043691)2.40791561
135aromatic amino acid family catabolic process (GO:0009074)2.40772822
136embryo implantation (GO:0007566)2.40503707
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40114130
138acylglycerol homeostasis (GO:0055090)2.39185138
139triglyceride homeostasis (GO:0070328)2.39185138
140protein-lipid complex assembly (GO:0065005)2.38941005
141regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38682153
142wound healing, spreading of epidermal cells (GO:0035313)2.38380602
143urea cycle (GO:0000050)2.38377020
144urea metabolic process (GO:0019627)2.38377020
145collagen metabolic process (GO:0032963)2.36251873
146nucleotide-sugar biosynthetic process (GO:0009226)2.36003791
147glyoxylate metabolic process (GO:0046487)2.35383987
148activation of Rac GTPase activity (GO:0032863)2.35002687
149endothelial cell morphogenesis (GO:0001886)2.32903918
150regulation of protein activation cascade (GO:2000257)2.32868485
151regulation of extracellular matrix organization (GO:1903053)2.32867918
152extracellular matrix disassembly (GO:0022617)2.32822921
153plasma lipoprotein particle assembly (GO:0034377)2.32516935
154multicellular organismal macromolecule metabolic process (GO:0044259)2.31932466
155protein heterotrimerization (GO:0070208)2.31530272
156positive regulation of triglyceride biosynthetic process (GO:0010867)2.31133325
157NADPH regeneration (GO:0006740)2.28392193
158* Golgi organization (GO:0007030)2.28253620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.17684673
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.83935489
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.60683933
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.15107077
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12177861
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.01546746
7CLOCK_20551151_ChIP-Seq_293T_Human2.96260525
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85681773
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40968499
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40944458
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37889278
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30424789
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26640099
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.24821563
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.18637377
16GATA1_22025678_ChIP-Seq_K562_Human1.99128741
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96092872
18E2F7_22180533_ChIP-Seq_HELA_Human1.92932292
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.89922777
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87749169
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83919386
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83202832
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82684458
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77310507
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66636987
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66287271
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63493780
28MYC_22102868_ChIP-Seq_BL_Human1.63245741
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61043994
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58636335
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57614854
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56270871
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55618289
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55157465
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.53965793
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52269084
37ATF3_27146783_Chip-Seq_COLON_Human1.51025261
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48869149
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47174136
40* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44953664
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41699495
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38790691
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38785774
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37769636
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37394918
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35763926
47TFEB_21752829_ChIP-Seq_HELA_Human1.35576634
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35310524
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.35172810
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.33108490
51LXR_22292898_ChIP-Seq_THP-1_Human1.31204741
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30266735
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30191622
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30161782
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29786681
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28854931
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28368778
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28192448
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26574707
60RACK7_27058665_Chip-Seq_MCF-7_Human1.25973722
61TP53_22127205_ChIP-Seq_IMR90_Human1.25310942
62GATA4_25053715_ChIP-Seq_YYC3_Human1.24513264
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22884048
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21922261
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.19962133
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19470488
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19470488
68GATA6_25053715_ChIP-Seq_YYC3_Human1.19171371
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18109809
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17984248
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17753019
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17339764
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16661297
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16559931
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16482461
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15382875
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15370172
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13712886
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12986609
80VDR_21846776_ChIP-Seq_THP-1_Human1.12589698
81KDM2B_26808549_Chip-Seq_K562_Human1.10097992
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07564511
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07447583
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07430754
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06550433
86KDM2B_26808549_Chip-Seq_DND41_Human1.05915844
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04740806
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03929128
89* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03737199
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03589887
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.03576514
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02089217
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01926387
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01245616
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00490092
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00280932
97SOX2_20726797_ChIP-Seq_SW620_Human0.99819780
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.98869338
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97697551
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97079781
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96122066
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95552107
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94991658
104* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94921551
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94512863
106NCOR1_26117541_ChIP-Seq_K562_Human0.94292728
107AR_21909140_ChIP-Seq_LNCAP_Human0.94110804
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93916033
109CHD1_26751641_Chip-Seq_LNCaP_Human0.93505626
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93119604
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92946696
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92807477
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92321835
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92262071
115* UTX_26944678_Chip-Seq_JUKART_Human0.92214977
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91965833
117MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91517844
118GATA3_24758297_ChIP-Seq_MCF-7_Human0.91417783
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.91005696
120ZNF263_19887448_ChIP-Seq_K562_Human0.90869536
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90720158
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90389127
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90214648
124TCF7_22412390_ChIP-Seq_EML_Mouse0.90118798
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89444005
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88950858
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88463768
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88241691
129GABP_17652178_ChIP-ChIP_JURKAT_Human0.88138026
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87996465
131* TBX20_22080862_ChIP-Seq_HEART_Mouse0.87831524
132* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87831524
133VDR_24763502_ChIP-Seq_THP-1_Human0.87589052
134MAF_26560356_Chip-Seq_TH1_Human0.86592202
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86484546
136GABP_19822575_ChIP-Seq_HepG2_Human0.86094338
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86089383
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85399864
139UBF1/2_26484160_Chip-Seq_HMECs_Human0.85030084
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84080588
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84046955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.42634845
2MP0008438_abnormal_cutaneous_collagen3.26729393
3MP0002877_abnormal_melanocyte_morpholog3.10042550
4MP0005360_urolithiasis3.01709321
5MP0003705_abnormal_hypodermis_morpholog2.91056540
6MP0005365_abnormal_bile_salt2.74778373
7MP0005451_abnormal_body_composition2.53212066
8MP0003283_abnormal_digestive_organ2.43679723
9MP0009840_abnormal_foam_cell2.34882404
10MP0003195_calcinosis2.29890560
11MP0006054_spinal_hemorrhage2.23418747
12MP0005220_abnormal_exocrine_pancreas2.22521611
13MP0003252_abnormal_bile_duct2.21704313
14MP0003300_gastrointestinal_ulcer2.20356510
15MP0005085_abnormal_gallbladder_physiolo2.04488944
16MP0004858_abnormal_nervous_system1.92544151
17MP0001666_abnormal_nutrient_absorption1.91851869
18MP0005275_abnormal_skin_tensile1.88580737
19MP0005623_abnormal_meninges_morphology1.86842066
20MP0001944_abnormal_pancreas_morphology1.86824362
21MP0005083_abnormal_biliary_tract1.84240568
22MP0000013_abnormal_adipose_tissue1.79739754
23MP0002693_abnormal_pancreas_physiology1.77550471
24MP0003806_abnormal_nucleotide_metabolis1.73364538
25MP0005058_abnormal_lysosome_morphology1.70363984
26MP0003566_abnormal_cell_adhesion1.67430615
27MP0004233_abnormal_muscle_weight1.63839122
28MP0003941_abnormal_skin_development1.62269502
29MP0004264_abnormal_extraembryonic_tissu1.61981796
30MP0010352_gastrointestinal_tract_polyps1.55487557
31MP0003183_abnormal_peptide_metabolism1.54279931
32MP0009643_abnormal_urine_homeostasis1.51254786
33MP0010329_abnormal_lipoprotein_level1.49806891
34MP0008260_abnormal_autophagy1.46840011
35MP0005409_darkened_coat_color1.41161114
36MP0002796_impaired_skin_barrier1.39770720
37MP0003453_abnormal_keratinocyte_physiol1.38914215
38MP0009384_cardiac_valve_regurgitation1.37265516
39MP0002896_abnormal_bone_mineralization1.36437198
40MP0002909_abnormal_adrenal_gland1.36093299
41MP0000609_abnormal_liver_physiology1.36023653
42MP0009780_abnormal_chondrocyte_physiolo1.34649104
43MP0008875_abnormal_xenobiotic_pharmacok1.34372878
44MP0005503_abnormal_tendon_morphology1.33886918
45MP0005257_abnormal_intraocular_pressure1.32820445
46MP0003950_abnormal_plasma_membrane1.32115279
47MP0005023_abnormal_wound_healing1.32031760
48MP0002138_abnormal_hepatobiliary_system1.27421524
49MP0000678_abnormal_parathyroid_gland1.24566307
50MP0005501_abnormal_skin_physiology1.21399908
51MP0002078_abnormal_glucose_homeostasis1.20436900
52MP0005076_abnormal_cell_differentiation1.18785508
53MP0003436_decreased_susceptibility_to1.17891130
54MP0003191_abnormal_cellular_cholesterol1.17350425
55MP0000767_abnormal_smooth_muscle1.16369543
56MP0003279_aneurysm1.15831053
57MP0001915_intracranial_hemorrhage1.15830023
58MP0004272_abnormal_basement_membrane1.15210406
59MP0004043_abnormal_pH_regulation1.13401711
60MP0004782_abnormal_surfactant_physiolog1.13318648
61MP0010234_abnormal_vibrissa_follicle1.12286913
62MP0000003_abnormal_adipose_tissue1.11993168
63MP0000537_abnormal_urethra_morphology1.10106159
64MP0003329_amyloid_beta_deposits1.09797710
65MP0002089_abnormal_postnatal_growth/wei1.09658741
66MP0001533_abnormal_skeleton_physiology1.08822504
67MP0010030_abnormal_orbit_morphology1.06266223
68MP0002060_abnormal_skin_morphology1.05844022
69MP0005332_abnormal_amino_acid1.05753219
70MP0001661_extended_life_span1.04568038
71MP0002118_abnormal_lipid_homeostasis1.04545177
72MP0005319_abnormal_enzyme/_coenzyme1.04152056
73MP0002933_joint_inflammation1.03550789
74MP0002928_abnormal_bile_duct1.02116034
75MP0001216_abnormal_epidermal_layer1.00654325
76MP0000598_abnormal_liver_morphology0.98176717
77MP0001243_abnormal_dermal_layer0.98015968
78MP0003172_abnormal_lysosome_physiology0.97763411
79MP0001730_embryonic_growth_arrest0.96058309
80MP0003868_abnormal_feces_composition0.95463099
81MP0000462_abnormal_digestive_system0.94053555
82MP0001756_abnormal_urination0.93980601
83MP0001348_abnormal_lacrimal_gland0.93668364
84MP0003795_abnormal_bone_structure0.92970382
85MP0000733_abnormal_muscle_development0.92218987
86MP0002837_dystrophic_cardiac_calcinosis0.89608064
87MP0004947_skin_inflammation0.89376712
88MP0001542_abnormal_bone_strength0.88722130
89MP0005636_abnormal_mineral_homeostasis0.86154059
90MP0002295_abnormal_pulmonary_circulatio0.85496113
91MP0004185_abnormal_adipocyte_glucose0.85432263
92MP0005621_abnormal_cell_physiology0.85198709
93MP0005408_hypopigmentation0.85011676
94MP0005165_increased_susceptibility_to0.84782573
95MP0001958_emphysema0.84321824
96MP0000604_amyloidosis0.82572355
97MP0010386_abnormal_urinary_bladder0.82315128
98MP0010368_abnormal_lymphatic_system0.82276522
99MP0003303_peritoneal_inflammation0.81544002
100MP0000762_abnormal_tongue_morphology0.81116365
101MP0000467_abnormal_esophagus_morphology0.81020932
102MP0005390_skeleton_phenotype0.80760408
103MP0003448_altered_tumor_morphology0.80568176
104MP0000858_altered_metastatic_potential0.80457909
105MP0005375_adipose_tissue_phenotype0.79044368
106MP0003959_abnormal_lean_body0.78523743
107MP0000751_myopathy0.78470974
108MP0002086_abnormal_extraembryonic_tissu0.78062439
109MP0005084_abnormal_gallbladder_morpholo0.77882323
110MP0009053_abnormal_anal_canal0.77433926
111MP0000163_abnormal_cartilage_morphology0.76856771
112MP0005508_abnormal_skeleton_morphology0.75923365
113MP0003186_abnormal_redox_activity0.75194921
114MP0001765_abnormal_ion_homeostasis0.74938869
115MP0000613_abnormal_salivary_gland0.72066477
116MP0008469_abnormal_protein_level0.71929123
117MP0004019_abnormal_vitamin_homeostasis0.71497762
118MP0002234_abnormal_pharynx_morphology0.71442411
119MP0001881_abnormal_mammary_gland0.71305679
120MP0000490_abnormal_crypts_of0.70616697
121MP0009931_abnormal_skin_appearance0.69724556
122MP0002254_reproductive_system_inflammat0.69118400
123MP0001845_abnormal_inflammatory_respons0.68308351
124MP0005197_abnormal_uvea_morphology0.68259602
125MP0000627_abnormal_mammary_gland0.67981693
126MP0000534_abnormal_ureter_morphology0.67699066
127MP0003385_abnormal_body_wall0.67377570
128MP0009642_abnormal_blood_homeostasis0.67187281
129MP0004957_abnormal_blastocyst_morpholog0.66302656
130MP0005379_endocrine/exocrine_gland_phen0.65856249
131MP0000477_abnormal_intestine_morphology0.65158468
132MP0002080_prenatal_lethality0.64781318
133MP0005670_abnormal_white_adipose0.64330368
134MP0003091_abnormal_cell_migration0.64182066
135MP0001614_abnormal_blood_vessel0.64005246
136MP0001849_ear_inflammation0.63872479
137MP0002168_other_aberrant_phenotype0.63758900
138MP0002970_abnormal_white_adipose0.63075959
139MP0009672_abnormal_birth_weight0.63035137
140MP0002115_abnormal_skeleton_extremities0.62006108
141MP0005666_abnormal_adipose_tissue0.60670260
142MP0010771_integument_phenotype0.60179903
143MP0009333_abnormal_splenocyte_physiolog0.59517344
144MP0002998_abnormal_bone_remodeling0.59158074
145MP0008961_abnormal_basal_metabolism0.58431193

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.04115927
2Hypoglycemic seizures (HP:0002173)4.31701068
3Hyperinsulinemic hypoglycemia (HP:0000825)4.30418899
4Protrusio acetabuli (HP:0003179)3.81239551
5Abnormality of the intrinsic pathway (HP:0010989)3.70095532
6Symptomatic seizures (HP:0011145)3.57207269
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46162618
8Hyperglycemia (HP:0003074)3.33994956
9Premature rupture of membranes (HP:0001788)3.30300919
10Abnormality of the common coagulation pathway (HP:0010990)3.24718027
11Deep venous thrombosis (HP:0002625)3.21724493
12Ketoacidosis (HP:0001993)3.20313504
13Urinary glycosaminoglycan excretion (HP:0003541)3.19504496
14Mucopolysacchariduria (HP:0008155)3.19504496
15Late onset (HP:0003584)3.16900332
16Xanthomatosis (HP:0000991)3.04318930
17Cervical subluxation (HP:0003308)2.98464612
18Abnormality of polysaccharide metabolism (HP:0011012)2.93725969
19Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93725969
20Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93725969
21Abnormality of endocrine pancreas physiology (HP:0012093)2.92092417
22Abnormality of the pancreatic islet cells (HP:0006476)2.92092417
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89446009
24Dysostosis multiplex (HP:0000943)2.86212971
25Fragile skin (HP:0001030)2.84769445
26Intrahepatic cholestasis (HP:0001406)2.84575367
27Insulin-resistant diabetes mellitus (HP:0000831)2.76655628
28Wormian bones (HP:0002645)2.76624785
29Spinal rigidity (HP:0003306)2.75404325
30Thoracolumbar scoliosis (HP:0002944)2.74211850
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73009419
32Short nail (HP:0001799)2.67885935
33Ketosis (HP:0001946)2.66936224
34Achilles tendon contracture (HP:0001771)2.65598591
35Osteolytic defects of the hand bones (HP:0009699)2.65135877
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.65135877
37Vascular tortuosity (HP:0004948)2.61906275
38Generalized aminoaciduria (HP:0002909)2.61801519
39Peritonitis (HP:0002586)2.61402452
40Abnormality of the Achilles tendon (HP:0005109)2.60535038
41Cerebral aneurysm (HP:0004944)2.57351033
42Insulin resistance (HP:0000855)2.57107669
43Bladder diverticulum (HP:0000015)2.56492102
44Arterial tortuosity (HP:0005116)2.55995385
45Abnormality of dentin (HP:0010299)2.53129739
46Ulnar bowing (HP:0003031)2.47695262
47Beaking of vertebral bodies (HP:0004568)2.42512618
48Abnormality of carpal bone ossification (HP:0006257)2.39657979
49Pancreatic islet-cell hyperplasia (HP:0004510)2.39460419
50Hyperacusis (HP:0010780)2.38453080
51Protuberant abdomen (HP:0001538)2.38270501
52Hypobetalipoproteinemia (HP:0003563)2.37154238
53Shallow orbits (HP:0000586)2.36947670
54Vacuolated lymphocytes (HP:0001922)2.36857955
55Skin nodule (HP:0200036)2.33247458
56Vertebral compression fractures (HP:0002953)2.28108507
57Aortic aneurysm (HP:0004942)2.25813966
58Abdominal distention (HP:0003270)2.25300180
59Thin bony cortex (HP:0002753)2.24455675
60Elbow flexion contracture (HP:0002987)2.24041546
61Aortic dissection (HP:0002647)2.20936928
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20644175
63Asymmetry of the thorax (HP:0001555)2.20575280
64Increased connective tissue (HP:0009025)2.20198155
65Abnormal ossification of hand bones (HP:0005921)2.19733934
66Aneurysm (HP:0002617)2.19677735
67Distal upper limb amyotrophy (HP:0007149)2.18101130
68Upper limb amyotrophy (HP:0009129)2.18101130
69Abnormal delivery (HP:0001787)2.16989684
70Distal lower limb amyotrophy (HP:0008944)2.16029049
71Cardiovascular calcification (HP:0011915)2.15990521
72Natal tooth (HP:0000695)2.15947976
73Mildly elevated creatine phosphokinase (HP:0008180)2.15908282
74Metaphyseal cupping (HP:0003021)2.14795763
75Abnormality of purine metabolism (HP:0004352)2.14405014
76Disproportionate tall stature (HP:0001519)2.12376628
77Abnormal cartilage morphology (HP:0002763)2.09603157
78Genu recurvatum (HP:0002816)2.09038896
79Broad face (HP:0000283)2.08524696
80Fat malabsorption (HP:0002630)2.07951554
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07511009
82Abnormality of oral frenula (HP:0000190)2.07208906
83Long toe (HP:0010511)2.07191940
84Hydroxyprolinuria (HP:0003080)2.06616955
85Abnormality of proline metabolism (HP:0010907)2.06616955
86Complement deficiency (HP:0004431)2.06504580
87Abnormal pancreas size (HP:0012094)2.05511985
88Follicular hyperkeratosis (HP:0007502)2.03094504
89Hand muscle atrophy (HP:0009130)2.02726180
90Nonimmune hydrops fetalis (HP:0001790)2.01911075
91Platyspondyly (HP:0000926)2.00528374
92Hemorrhage of the eye (HP:0011885)2.00470893
93Hypolipoproteinemia (HP:0010981)1.97233338
94Mitral regurgitation (HP:0001653)1.96798086
95Abnormal foot bone ossification (HP:0010675)1.95351693
96Conjugated hyperbilirubinemia (HP:0002908)1.95284685
97Hyperextensible skin (HP:0000974)1.94308010
98Elevated alkaline phosphatase (HP:0003155)1.93898378
99Myocardial infarction (HP:0001658)1.93701137
100Abnormal enzyme/coenzyme activity (HP:0012379)1.93513113
101Severe short stature (HP:0003510)1.92957816
102Abnormal tarsal ossification (HP:0008369)1.92197948
103Blue sclerae (HP:0000592)1.91216670
104Abnormality of alkaline phosphatase activity (HP:0004379)1.91089349
105Increased variability in muscle fiber diameter (HP:0003557)1.90102403
106Trismus (HP:0000211)1.89999922
107Ankyloglossia (HP:0010296)1.89850658
108Advanced eruption of teeth (HP:0006288)1.89037974
109Gout (HP:0001997)1.89016842
110Ankle contracture (HP:0006466)1.88867765
111Abnormality of complement system (HP:0005339)1.88673595
112Prolonged partial thromboplastin time (HP:0003645)1.88232265
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.88133472
114Generalized amyotrophy (HP:0003700)1.87041047
115Joint laxity (HP:0001388)1.86867422
116Flat acetabular roof (HP:0003180)1.85811780
117Vascular calcification (HP:0004934)1.85688565
118Coxa vara (HP:0002812)1.85407116
119Dilatation of the ascending aorta (HP:0005111)1.83811175
120Back pain (HP:0003418)1.81719225
121Ovoid vertebral bodies (HP:0003300)1.81575632
122Joint stiffness (HP:0001387)1.81393150
123Abnormality of the acetabulum (HP:0003170)1.81152552
124Distal lower limb muscle weakness (HP:0009053)1.81072207
125Large for gestational age (HP:0001520)1.80671454
126Atrophic scars (HP:0001075)1.80634398
127Soft skin (HP:0000977)1.79494191
128Hyperparathyroidism (HP:0000843)1.78392441
129Biconcave vertebral bodies (HP:0004586)1.77230765
130Neonatal short-limb short stature (HP:0008921)1.76884114
131Hypoalphalipoproteinemia (HP:0003233)1.76630661
132Cupped ribs (HP:0000887)1.76040209
133Abnormality of the distal phalanges of the toes (HP:0010182)1.75080647
134Abnormality of skeletal muscle fiber size (HP:0012084)1.73800227
135Thin skin (HP:0000963)1.72749992
136Abnormality of fatty-acid metabolism (HP:0004359)1.72302510
137Ectopia lentis (HP:0001083)1.72245387
138Mitral stenosis (HP:0001718)1.71939666
139Osteoarthritis (HP:0002758)1.71841640
140Spondylolisthesis (HP:0003302)1.71694970
141Renal duplication (HP:0000075)1.69411718
142Insomnia (HP:0100785)1.69398469
143Spinal cord lesions (HP:0100561)1.69352990
144Syringomyelia (HP:0003396)1.69352990
145Abnormality of liposaccharide metabolism (HP:0010968)1.69202648
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.69202648
147Abnormality of glycolipid metabolism (HP:0010969)1.69202648
148Neonatal death (HP:0003811)1.67929776
149Epiphyseal dysplasia (HP:0002656)1.66939294
150Breech presentation (HP:0001623)1.66663847
151Mitral valve prolapse (HP:0001634)1.66535104
152Broad metatarsal (HP:0001783)1.66190052
153Abnormality of nucleobase metabolism (HP:0010932)1.66170900
154Asymmetric septal hypertrophy (HP:0001670)1.65452412
155Abnormal hand bone ossification (HP:0010660)1.64433839
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63975781
157Exostoses (HP:0100777)1.63491918
158Exocrine pancreatic insufficiency (HP:0001738)1.63398814
159Long palpebral fissure (HP:0000637)1.63107082
160Retinal atrophy (HP:0001105)1.62991003
161Congenital glaucoma (HP:0001087)1.61965021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.14336008
2TRIB34.04799719
3PASK3.04258307
4SMG13.01241851
5PKN22.88180425
6INSRR2.83428427
7TAOK32.67996474
8FLT32.56269542
9ICK2.51536544
10BCKDK2.35974677
11SIK12.32301056
12PRPF4B2.21678249
13EPHA32.06231191
14SCYL21.90971365
15PDGFRA1.90834447
16CDK121.90358810
17PTK61.89839050
18LATS21.81249956
19TESK11.80803174
20LATS11.74487832
21FGFR41.70809587
22MAPK151.61895180
23FRK1.58910359
24MAP3K31.56144918
25EEF2K1.54269093
26RIPK11.53592389
27ARAF1.47334642
28LMTK21.41291167
29MAP3K101.40049861
30PTK21.38848152
31TTN1.37437399
32TAOK21.30014693
33JAK31.28599517
34TBK11.26547548
35PIK3CG1.26026364
36NEK91.23483728
37PRKD31.18952582
38HIPK21.17517854
39LRRK21.15791547
40RPS6KA41.15675997
41EPHA21.12383178
42DDR21.11116062
43MET1.10822674
44MYLK1.06185396
45ZAP701.04848582
46TYK21.04656340
47MAPKAPK31.03809084
48EPHB11.02791349
49MAP3K21.01314231
50DYRK1B1.00851370
51MAP2K30.94069134
52PAK40.92099579
53IRAK30.91276659
54TESK20.90066889
55NME20.89780111
56MAP3K10.89067483
57MOS0.88897986
58EIF2AK30.88762579
59KDR0.87408668
60EPHB20.85675634
61BRSK20.81092142
62JAK10.79764272
63MAP2K20.78883920
64STK100.78089677
65PRKD20.77112864
66MST1R0.72699674
67CLK10.72594326
68CDK70.72570571
69TGFBR10.71679765
70MTOR0.71540258
71FER0.70072312
72JAK20.68866746
73PAK20.68249853
74MAP3K80.65947558
75MAP3K110.65945974
76PDPK10.64419901
77ACVR1B0.64272900
78PIM20.62991637
79STK30.62110674
80CSK0.60372494
81RPS6KA20.59850821
82BRAF0.59479618
83TGFBR20.59404754
84PRKG20.57589252
85RET0.57094758
86PAK30.56361152
87MAP3K130.56275914
88PBK0.55593002
89FGFR30.55440233
90STK380.55429986
91BTK0.53884605
92ERBB40.53520128
93LIMK10.53303895
94CHUK0.53302290
95RPS6KB20.52469673
96ITK0.52241094
97TAOK10.51903062
98MAPK110.50896759
99CDK80.50513338
100MAP3K140.50205623
101PDGFRB0.49851220
102NTRK10.49592718
103MAP3K60.47672868
104NEK10.46109891
105BMX0.45915312
106IRAK10.45761008
107STK38L0.44719882
108MAP4K10.44676584
109CDK60.44338852
110MAP2K10.44271772
111WNK40.43757594
112CDK90.41159140
113CDK40.40276998
114TTK0.40194213
115EIF2AK10.38873317
116MAPKAPK20.38863493
117RAF10.38688421
118TRPM70.38443134
119PAK10.38129425
120ILK0.37058896
121ABL20.36748453
122ROCK20.36685186
123NLK0.36643867
124AKT20.36190515
125IRAK20.35106439
126MELK0.34466490
127KSR20.34194074
128DAPK30.33787616
129IGF1R0.31189523
130DYRK30.31155020
131CDC42BPA0.30897762
132CAMK1D0.30718346
133PRKCH0.29996991
134BUB10.29887639
135CAMKK20.28921145
136GSK3A0.27998355
137IRAK40.27130983

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.43219431
2Protein export_Homo sapiens_hsa030603.56863635
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.24559123
4Sulfur metabolism_Homo sapiens_hsa009202.56099063
5Selenocompound metabolism_Homo sapiens_hsa004502.54601766
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26098714
7Tryptophan metabolism_Homo sapiens_hsa003802.02549646
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.02274695
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.98104234
10Folate biosynthesis_Homo sapiens_hsa007901.86110020
11Fatty acid degradation_Homo sapiens_hsa000711.81226107
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80147436
13N-Glycan biosynthesis_Homo sapiens_hsa005101.79535650
14Fat digestion and absorption_Homo sapiens_hsa049751.72926478
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66994583
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.62732293
17Caffeine metabolism_Homo sapiens_hsa002321.55721507
18Complement and coagulation cascades_Homo sapiens_hsa046101.53778299
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49372856
20Starch and sucrose metabolism_Homo sapiens_hsa005001.46550019
21Other glycan degradation_Homo sapiens_hsa005111.46337289
22Galactose metabolism_Homo sapiens_hsa000521.45941198
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45782125
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44945371
25Lysosome_Homo sapiens_hsa041421.42399092
26Nitrogen metabolism_Homo sapiens_hsa009101.34042525
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24329782
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.21482153
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21190362
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19270147
31Arginine biosynthesis_Homo sapiens_hsa002201.17957906
32Histidine metabolism_Homo sapiens_hsa003401.16019333
33Vitamin B6 metabolism_Homo sapiens_hsa007501.14544979
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11845076
35Fatty acid metabolism_Homo sapiens_hsa012121.10088071
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09337997
37Pancreatic cancer_Homo sapiens_hsa052121.08657595
38Protein digestion and absorption_Homo sapiens_hsa049741.06599781
39Insulin resistance_Homo sapiens_hsa049311.04680457
40PPAR signaling pathway_Homo sapiens_hsa033201.02636865
41Peroxisome_Homo sapiens_hsa041461.01605947
42Staphylococcus aureus infection_Homo sapiens_hsa051501.01541039
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00714684
44Legionellosis_Homo sapiens_hsa051341.00225206
45Shigellosis_Homo sapiens_hsa051310.95572725
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95479140
47Non-small cell lung cancer_Homo sapiens_hsa052230.94930596
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94460681
49One carbon pool by folate_Homo sapiens_hsa006700.90622499
50Acute myeloid leukemia_Homo sapiens_hsa052210.88686990
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87771374
52Carbon metabolism_Homo sapiens_hsa012000.86352172
53Bladder cancer_Homo sapiens_hsa052190.85791847
54Lysine degradation_Homo sapiens_hsa003100.84936003
55ABC transporters_Homo sapiens_hsa020100.84045019
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84028746
57Sphingolipid metabolism_Homo sapiens_hsa006000.83407654
58Antigen processing and presentation_Homo sapiens_hsa046120.82993804
59Biosynthesis of amino acids_Homo sapiens_hsa012300.82458114
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81856246
61Phenylalanine metabolism_Homo sapiens_hsa003600.81509572
62Fatty acid elongation_Homo sapiens_hsa000620.80586495
63Propanoate metabolism_Homo sapiens_hsa006400.79658842
64Renin-angiotensin system_Homo sapiens_hsa046140.77456705
65MicroRNAs in cancer_Homo sapiens_hsa052060.76366095
66Pyruvate metabolism_Homo sapiens_hsa006200.76360724
67Butanoate metabolism_Homo sapiens_hsa006500.75949912
68Endometrial cancer_Homo sapiens_hsa052130.74067598
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.73950440
70Arginine and proline metabolism_Homo sapiens_hsa003300.73518871
71Insulin signaling pathway_Homo sapiens_hsa049100.72861044
72VEGF signaling pathway_Homo sapiens_hsa043700.72693165
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72690252
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72307917
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70898460
76Salmonella infection_Homo sapiens_hsa051320.70319868
77Pentose phosphate pathway_Homo sapiens_hsa000300.70031978
78Prostate cancer_Homo sapiens_hsa052150.68513834
79ECM-receptor interaction_Homo sapiens_hsa045120.68512834
80Vibrio cholerae infection_Homo sapiens_hsa051100.68391235
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67383354
82Steroid biosynthesis_Homo sapiens_hsa001000.65092389
83Sulfur relay system_Homo sapiens_hsa041220.64773101
84Notch signaling pathway_Homo sapiens_hsa043300.63792484
85Bile secretion_Homo sapiens_hsa049760.63272440
86beta-Alanine metabolism_Homo sapiens_hsa004100.63186847
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62980000
88Hepatitis C_Homo sapiens_hsa051600.62488761
89Renal cell carcinoma_Homo sapiens_hsa052110.61834814
90Type II diabetes mellitus_Homo sapiens_hsa049300.60312158
91Chemical carcinogenesis_Homo sapiens_hsa052040.59302089
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59201349
93Prion diseases_Homo sapiens_hsa050200.59145189
94Fructose and mannose metabolism_Homo sapiens_hsa000510.59092555
95Glioma_Homo sapiens_hsa052140.58408225
96Vitamin digestion and absorption_Homo sapiens_hsa049770.58120650
97Tyrosine metabolism_Homo sapiens_hsa003500.56002950
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55696890
99Focal adhesion_Homo sapiens_hsa045100.55401587
100Amoebiasis_Homo sapiens_hsa051460.55283967
101Prolactin signaling pathway_Homo sapiens_hsa049170.54708049
102Endocytosis_Homo sapiens_hsa041440.54588627
103Hepatitis B_Homo sapiens_hsa051610.52995859
104Glutathione metabolism_Homo sapiens_hsa004800.52993747
105Fatty acid biosynthesis_Homo sapiens_hsa000610.50131617
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.49540379
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49506465
108Thyroid hormone synthesis_Homo sapiens_hsa049180.49036450
109Chronic myeloid leukemia_Homo sapiens_hsa052200.48288602
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48108296
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47743251
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47121854
113Viral carcinogenesis_Homo sapiens_hsa052030.46844916
114HIF-1 signaling pathway_Homo sapiens_hsa040660.46812737
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.46100807
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45578323
117mTOR signaling pathway_Homo sapiens_hsa041500.45320787
118Pertussis_Homo sapiens_hsa051330.45136470
119Glucagon signaling pathway_Homo sapiens_hsa049220.44703439
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.44554403
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.43764196
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43071434
123Small cell lung cancer_Homo sapiens_hsa052220.42158077
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41689182
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41529880
126Glycerolipid metabolism_Homo sapiens_hsa005610.40613495
127Adherens junction_Homo sapiens_hsa045200.40277355
128Toxoplasmosis_Homo sapiens_hsa051450.40174151
129Leishmaniasis_Homo sapiens_hsa051400.40157327
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37488131
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.37334220
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36586713
133Type I diabetes mellitus_Homo sapiens_hsa049400.36306522
134AMPK signaling pathway_Homo sapiens_hsa041520.35894728
135Proteoglycans in cancer_Homo sapiens_hsa052050.34696582
136Apoptosis_Homo sapiens_hsa042100.33736264
137Thyroid cancer_Homo sapiens_hsa052160.33462542
138TNF signaling pathway_Homo sapiens_hsa046680.33224308
139Retinol metabolism_Homo sapiens_hsa008300.32330888

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