SURF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)4.99452868
2protein localization to kinetochore (GO:0034501)4.46293782
3behavioral response to nicotine (GO:0035095)4.43750013
4DNA unwinding involved in DNA replication (GO:0006268)4.41271882
5nuclear pore organization (GO:0006999)4.38923609
6nucleobase biosynthetic process (GO:0046112)4.36896424
7nuclear pore complex assembly (GO:0051292)4.36892907
8folic acid-containing compound biosynthetic process (GO:0009396)4.35484775
9DNA damage response, detection of DNA damage (GO:0042769)4.30972138
10negative regulation of gene silencing (GO:0060969)4.19435297
11purine nucleobase biosynthetic process (GO:0009113)4.17760220
12maturation of SSU-rRNA (GO:0030490)4.12636824
13tRNA modification (GO:0006400)4.06636341
14mitotic nuclear envelope disassembly (GO:0007077)4.05365196
15DNA strand renaturation (GO:0000733)3.96461600
16mitotic metaphase plate congression (GO:0007080)3.92860490
17negative regulation of cell aging (GO:0090344)3.88227250
18* ribosome biogenesis (GO:0042254)3.86727409
19DNA replication initiation (GO:0006270)3.84323276
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.84281510
21formation of translation preinitiation complex (GO:0001731)3.82721212
22DNA replication-dependent nucleosome assembly (GO:0006335)3.75663188
23DNA replication-dependent nucleosome organization (GO:0034723)3.75663188
24protein localization to chromosome, centromeric region (GO:0071459)3.74863256
25membrane disassembly (GO:0030397)3.74582568
26nuclear envelope disassembly (GO:0051081)3.74582568
27mitotic sister chromatid segregation (GO:0000070)3.70374352
28ribosome assembly (GO:0042255)3.69854475
29rRNA transcription (GO:0009303)3.64440920
30IMP biosynthetic process (GO:0006188)3.59365063
31mitotic chromosome condensation (GO:0007076)3.58507673
32DNA strand elongation involved in DNA replication (GO:0006271)3.58259416
33mitochondrial calcium ion transport (GO:0006851)3.57586827
34DNA replication checkpoint (GO:0000076)3.57274063
35* ribonucleoprotein complex biogenesis (GO:0022613)3.55974539
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53940063
37proline biosynthetic process (GO:0006561)3.53049627
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52076951
39DNA duplex unwinding (GO:0032508)3.50226676
40sister chromatid segregation (GO:0000819)3.50180720
41DNA geometric change (GO:0032392)3.47695379
42RNA modification (GO:0009451)3.47059539
43meiotic chromosome segregation (GO:0045132)3.42825645
44negative regulation of telomerase activity (GO:0051974)3.42690494
45DNA strand elongation (GO:0022616)3.42658392
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41677703
47regulation of spindle organization (GO:0090224)3.40142830
48pore complex assembly (GO:0046931)3.39437702
49regulation of DNA damage checkpoint (GO:2000001)3.39262341
50folic acid metabolic process (GO:0046655)3.38802172
51ribosomal large subunit biogenesis (GO:0042273)3.38261414
52RNA methylation (GO:0001510)3.36971856
53regulation of translational termination (GO:0006449)3.36155012
54histone arginine methylation (GO:0034969)3.34905240
55tRNA methylation (GO:0030488)3.34159300
56protein insertion into membrane (GO:0051205)3.34080048
57regulation of gene silencing by RNA (GO:0060966)3.33666625
58regulation of posttranscriptional gene silencing (GO:0060147)3.33666625
59regulation of gene silencing by miRNA (GO:0060964)3.33666625
60positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.31597759
61positive regulation of cell cycle G2/M phase transition (GO:1902751)3.31597759
62ATP synthesis coupled proton transport (GO:0015986)3.30928190
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30928190
64metaphase plate congression (GO:0051310)3.29976130
65rRNA processing (GO:0006364)3.29570476
66* cellular component biogenesis (GO:0044085)3.28702706
67intra-S DNA damage checkpoint (GO:0031573)3.26792922
68peptidyl-arginine methylation (GO:0018216)3.22751294
69peptidyl-arginine N-methylation (GO:0035246)3.22751294
70positive regulation of chromosome segregation (GO:0051984)3.22181277
71regulation of RNA export from nucleus (GO:0046831)3.21313349
72cellular response to ATP (GO:0071318)3.21293530
73rRNA metabolic process (GO:0016072)3.19400693
74positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.19312809
75viral transcription (GO:0019083)3.18547992
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16268964
77ribosomal small subunit biogenesis (GO:0042274)3.15810866
78translational termination (GO:0006415)3.14815226
79ncRNA processing (GO:0034470)3.14781306
80translational initiation (GO:0006413)3.12496575
81telomere maintenance via semi-conservative replication (GO:0032201)3.11946300
82pyrimidine nucleotide catabolic process (GO:0006244)3.11268616
83rRNA methylation (GO:0031167)3.11024694
84pre-miRNA processing (GO:0031054)3.08088076
85ribosomal small subunit assembly (GO:0000028)3.08006718
86regulation of mitochondrial translation (GO:0070129)3.07341286
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.06170842
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06170842
89termination of RNA polymerase III transcription (GO:0006386)3.05093545
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.05093545
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.03183496
92viral life cycle (GO:0019058)3.02945971
93negative regulation of histone methylation (GO:0031061)3.02866946
94IMP metabolic process (GO:0046040)3.02604185
95base-excision repair, AP site formation (GO:0006285)3.02345433
96regulation of translational fidelity (GO:0006450)3.01829599
97heterochromatin organization (GO:0070828)2.99932720
98spliceosomal snRNP assembly (GO:0000387)2.99816989
99negative regulation of translational initiation (GO:0045947)2.99446567
100nuclear envelope organization (GO:0006998)2.98717683
101regulation of mitotic spindle organization (GO:0060236)2.97685565
102respiratory chain complex IV assembly (GO:0008535)2.96832240
103pseudouridine synthesis (GO:0001522)2.96429958
104peptidyl-histidine modification (GO:0018202)2.94876980
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94229013
106inner cell mass cell proliferation (GO:0001833)2.94030482
107cellular protein complex disassembly (GO:0043624)2.93641092
108mitotic G1 DNA damage checkpoint (GO:0031571)2.93352499
109tRNA processing (GO:0008033)2.93294075
110mitotic sister chromatid cohesion (GO:0007064)2.93184272
111fatty acid elongation (GO:0030497)2.93159556
112establishment of chromosome localization (GO:0051303)2.91606426
113negative regulation of RNA splicing (GO:0033119)2.90176764
114regulation of skeletal muscle contraction (GO:0014819)2.90168949
115positive regulation of DNA-templated transcription, elongation (GO:0032786)2.89705405
116transcription from mitochondrial promoter (GO:0006390)2.89403314
117regulation of translation in response to stress (GO:0043555)2.86838618
118ncRNA metabolic process (GO:0034660)2.85290236
119translational elongation (GO:0006414)2.84954880
120protein K6-linked ubiquitination (GO:0085020)2.84685941
121SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84658838
122protein localization to chromosome (GO:0034502)2.84559828
123mitotic cell cycle arrest (GO:0071850)2.84320568
124chaperone-mediated protein transport (GO:0072321)2.84302555
125protein complex disassembly (GO:0043241)2.84281726
126response to pheromone (GO:0019236)2.83997835
127cytochrome complex assembly (GO:0017004)2.83476882
128negative regulation of mRNA processing (GO:0050686)2.83449748
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.83073905
130histone H2A monoubiquitination (GO:0035518)2.82542426
131chromatin assembly or disassembly (GO:0006333)2.82515867
132RNA splicing, via transesterification reactions (GO:0000375)2.82513529
133histone H4-K12 acetylation (GO:0043983)2.82161276
134mitotic recombination (GO:0006312)2.81334680
135mRNA splicing, via spliceosome (GO:0000398)2.81299504
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81299504
137adenine nucleotide transport (GO:0051503)2.81143897
138termination of RNA polymerase II transcription (GO:0006369)2.80845157
139negative regulation of chromosome segregation (GO:0051985)2.80628341
140DNA conformation change (GO:0071103)2.80440029
141membrane tubulation (GO:0097320)2.79995296
142adenosine receptor signaling pathway (GO:0001973)2.79567078
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.79528498
144regulation of chromosome segregation (GO:0051983)2.79260320
145mitochondrial RNA metabolic process (GO:0000959)2.79118608
146cotranslational protein targeting to membrane (GO:0006613)2.79000695
147chromatin assembly (GO:0031497)2.78709021
148protein targeting to ER (GO:0045047)2.78701632
149telomere maintenance via recombination (GO:0000722)2.77818345
150rRNA modification (GO:0000154)2.77226674
151establishment of protein localization to mitochondrion (GO:0072655)2.76453516
152regulation of histone H3-K9 methylation (GO:0051570)2.74888835
153regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.74850139
154DNA replication-independent nucleosome assembly (GO:0006336)2.73362173
155DNA replication-independent nucleosome organization (GO:0034724)2.73362173
156dosage compensation (GO:0007549)2.72517658
157spindle checkpoint (GO:0031577)2.71487427
158G1 DNA damage checkpoint (GO:0044783)2.71397725
159DNA deamination (GO:0045006)2.71210342
160G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71080674
161regulation of telomere maintenance via telomerase (GO:0032210)2.69954258
162peptidyl-arginine omega-N-methylation (GO:0035247)2.69336814
163negative regulation of sister chromatid segregation (GO:0033046)2.67981329
164negative regulation of mitotic sister chromatid separation (GO:2000816)2.67981329
165negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67981329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12715763
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.43022580
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96823275
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40764398
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38135854
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21768328
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00231995
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99029468
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.62495562
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58775027
11MYC_22102868_ChIP-Seq_BL_Human2.50678501
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42306317
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.26735440
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.25716293
15P68_20966046_ChIP-Seq_HELA_Human2.15323318
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15129694
17* XRN2_22483619_ChIP-Seq_HELA_Human2.14766408
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14337905
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08687355
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06829660
21LXR_22292898_ChIP-Seq_THP-1_Human2.06309187
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01235510
23* GABP_17652178_ChIP-ChIP_JURKAT_Human2.01111151
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.91540301
25AR_21909140_ChIP-Seq_LNCAP_Human1.89100956
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86521205
27VDR_23849224_ChIP-Seq_CD4+_Human1.85834515
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82743859
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81519793
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79835477
31* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78619518
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77278930
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76219173
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.75492428
35CIITA_25753668_ChIP-Seq_RAJI_Human1.74028720
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72605715
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.72180923
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70570094
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68019168
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67818835
41KDM5A_27292631_Chip-Seq_BREAST_Human1.65712436
42MAF_26560356_Chip-Seq_TH2_Human1.64011699
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62611461
44* GABP_19822575_ChIP-Seq_HepG2_Human1.61076236
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59469872
46BCL6_27268052_Chip-Seq_Bcells_Human1.58215924
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57188641
48E2F1_20622854_ChIP-Seq_HELA_Human1.57133840
49DCP1A_22483619_ChIP-Seq_HELA_Human1.57117400
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57086576
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55533221
52TTF2_22483619_ChIP-Seq_HELA_Human1.53827941
53PHF8_20622854_ChIP-Seq_HELA_Human1.53398121
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52711627
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.51823520
56FOXP1_21924763_ChIP-Seq_HESCs_Human1.51688588
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50385195
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49854547
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.49672632
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49657080
61BCOR_27268052_Chip-Seq_Bcells_Human1.49382043
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.47852040
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.45318254
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45134250
65SMC4_20622854_ChIP-Seq_HELA_Human1.44794131
66VDR_21846776_ChIP-Seq_THP-1_Human1.44370102
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44076739
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44076739
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44076739
70RACK7_27058665_Chip-Seq_MCF-7_Human1.43216187
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.42661642
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.41331058
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39128821
74CTCF_27219007_Chip-Seq_Bcells_Human1.38759291
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37907649
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37464726
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36910522
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35654934
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34284962
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33478934
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33392711
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32969351
83YY1_22570637_ChIP-Seq_MALME-3M_Human1.32878057
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32592788
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.30652118
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30390761
87ELK1_19687146_ChIP-ChIP_HELA_Human1.29095765
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29028142
89CTCF_21964334_Chip-Seq_Bcells_Human1.28794309
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28637414
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27915341
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24991582
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.24425177
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.24150122
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23427390
96CREB1_26743006_Chip-Seq_LNCaP_Human1.23395744
97VDR_24763502_ChIP-Seq_THP-1_Human1.22367196
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19976764
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18561341
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18198975
101KDM2B_26808549_Chip-Seq_DND41_Human1.18040558
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16915457
103TFEB_21752829_ChIP-Seq_HELA_Human1.14769583
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14677419
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14209733
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14201678
107CTCF_20526341_ChIP-Seq_ESCs_Human1.13792546
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13287863
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.13192199
110ZNF263_19887448_ChIP-Seq_K562_Human1.12922870
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.12449560
112* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12427016
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12151000
114* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11428693
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.10367542
116RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10252797
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10004015
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09024484
119* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08567885
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08567302
121SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08059503
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06041701
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05759401
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05492001
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04800821
126* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03954878
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.01211754
128* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00011341
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98557923
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97925249
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97265075
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96072154
133UTX_26944678_Chip-Seq_JUKART_Human0.95533410
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94023620
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93411094
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92651321
137MYB_26560356_Chip-Seq_TH1_Human0.91403417
138MAF_26560356_Chip-Seq_TH1_Human0.91347196
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90464681
140SPI1_23547873_ChIP-Seq_NB4_Human0.88814282
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.87015179
142TCF7_22412390_ChIP-Seq_EML_Mouse0.85796155
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85590502
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85140887
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83950474
146* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82660795
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82655549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.46021971
2MP0003693_abnormal_embryo_hatching4.45863219
3MP0003111_abnormal_nucleus_morphology4.04965318
4MP0008057_abnormal_DNA_replication4.03057440
5MP0010094_abnormal_chromosome_stability3.99300419
6MP0004957_abnormal_blastocyst_morpholog3.84961200
7MP0003077_abnormal_cell_cycle3.62895050
8MP0001986_abnormal_taste_sensitivity3.50427694
9MP0005174_abnormal_tail_pigmentation3.33425670
10MP0005423_abnormal_somatic_nervous3.26683845
11MP0003136_yellow_coat_color3.08096342
12MP0009379_abnormal_foot_pigmentation2.81944311
13MP0008058_abnormal_DNA_repair2.70612507
14MP0005171_absent_coat_pigmentation2.68663385
15MP0010352_gastrointestinal_tract_polyps2.68047331
16MP0001730_embryonic_growth_arrest2.40235008
17MP0000350_abnormal_cell_proliferation2.35896787
18MP0000750_abnormal_muscle_regeneration2.34660998
19MP0001968_abnormal_touch/_nociception2.33706805
20MP0010307_abnormal_tumor_latency2.31224245
21MP0002396_abnormal_hematopoietic_system2.27363223
22MP0008007_abnormal_cellular_replicative2.24669355
23MP0008932_abnormal_embryonic_tissue2.18134218
24MP0002638_abnormal_pupillary_reflex2.11518417
25MP0002736_abnormal_nociception_after2.11421504
26MP0005076_abnormal_cell_differentiation2.06104044
27MP0005380_embryogenesis_phenotype2.01181572
28MP0001672_abnormal_embryogenesis/_devel2.01181572
29MP0003123_paternal_imprinting1.93635170
30MP0003984_embryonic_growth_retardation1.85882611
31MP0001502_abnormal_circadian_rhythm1.83192512
32MP0002088_abnormal_embryonic_growth/wei1.83062634
33MP0003786_premature_aging1.77470209
34MP0001697_abnormal_embryo_size1.75687924
35MP0000490_abnormal_crypts_of1.72980969
36MP0002160_abnormal_reproductive_system1.72641611
37MP0005083_abnormal_biliary_tract1.72549515
38MP0009333_abnormal_splenocyte_physiolog1.70300357
39MP0002086_abnormal_extraembryonic_tissu1.63623730
40MP0002085_abnormal_embryonic_tissue1.63540659
41MP0002080_prenatal_lethality1.63151161
42MP0002084_abnormal_developmental_patter1.60815582
43MP0003763_abnormal_thymus_physiology1.60258128
44MP0003890_abnormal_embryonic-extraembry1.53251900
45MP0003718_maternal_effect1.49402048
46MP0003705_abnormal_hypodermis_morpholog1.48488475
47MP0002019_abnormal_tumor_incidence1.48357486
48MP0004197_abnormal_fetal_growth/weight/1.46207699
49MP0004808_abnormal_hematopoietic_stem1.42527499
50MP0000313_abnormal_cell_death1.38336735
51MP0000015_abnormal_ear_pigmentation1.37905510
52MP0000703_abnormal_thymus_morphology1.37513092
53MP0008877_abnormal_DNA_methylation1.36715737
54MP0002398_abnormal_bone_marrow1.33660722
55MP0002735_abnormal_chemical_nociception1.32280004
56MP0003315_abnormal_perineum_morphology1.30005310
57MP0001919_abnormal_reproductive_system1.27185671
58MP0002722_abnormal_immune_system1.24742855
59MP0001293_anophthalmia1.21383557
60MP0000689_abnormal_spleen_morphology1.20116020
61MP0005377_hearing/vestibular/ear_phenot1.20106302
62MP0003878_abnormal_ear_physiology1.20106302
63MP0005501_abnormal_skin_physiology1.19111171
64MP0001545_abnormal_hematopoietic_system1.18980095
65MP0005397_hematopoietic_system_phenotyp1.18980095
66MP0008260_abnormal_autophagy1.18926371
67MP0004043_abnormal_pH_regulation1.17075982
68MP0009278_abnormal_bone_marrow1.15528776
69MP0006036_abnormal_mitochondrial_physio1.14617804
70MP0003567_abnormal_fetal_cardiomyocyte1.11526122
71MP0010030_abnormal_orbit_morphology1.08731429
72MP0001800_abnormal_humoral_immune1.08014356
73MP0000678_abnormal_parathyroid_gland1.06795774
74MP0000685_abnormal_immune_system1.04631097
75MP0004185_abnormal_adipocyte_glucose1.04214064
76MP0009053_abnormal_anal_canal1.03596382
77MP0000003_abnormal_adipose_tissue1.02151679
78MP0000538_abnormal_urinary_bladder1.01343937
79MP0003566_abnormal_cell_adhesion0.98743241
80MP0002653_abnormal_ependyma_morphology0.98147953
81MP0004381_abnormal_hair_follicle0.97528998
82MP0002429_abnormal_blood_cell0.96826030
83MP0004130_abnormal_muscle_cell0.96575214
84MP0005621_abnormal_cell_physiology0.96549606
85MP0003119_abnormal_digestive_system0.95451988
86MP0005645_abnormal_hypothalamus_physiol0.94534508
87MP0005023_abnormal_wound_healing0.93550681
88MP0008875_abnormal_xenobiotic_pharmacok0.93413475
89MP0002092_abnormal_eye_morphology0.93091305
90MP0001764_abnormal_homeostasis0.93021530
91MP0000716_abnormal_immune_system0.92617111
92MP0004858_abnormal_nervous_system0.92234675
93MP0004019_abnormal_vitamin_homeostasis0.91575661
94MP0001756_abnormal_urination0.91242013
95MP0006035_abnormal_mitochondrial_morpho0.90656755
96MP0005384_cellular_phenotype0.89651211
97MP0005389_reproductive_system_phenotype0.89499159
98MP0000049_abnormal_middle_ear0.89272992
99MP0000858_altered_metastatic_potential0.89140149
100MP0003303_peritoneal_inflammation0.88994886
101MP0009672_abnormal_birth_weight0.88297469
102MP0006292_abnormal_olfactory_placode0.88074170
103MP0003121_genomic_imprinting0.87154560
104MP0000428_abnormal_craniofacial_morphol0.86985889
105MP0002166_altered_tumor_susceptibility0.86771265
106MP0001849_ear_inflammation0.86199564
107MP0004133_heterotaxia0.86056607
108MP0005332_abnormal_amino_acid0.85847069
109MP0001145_abnormal_male_reproductive0.83450805
110MP0005330_cardiomyopathy0.83373085
111MP0002210_abnormal_sex_determination0.82923599
112MP0001915_intracranial_hemorrhage0.82676556
113MP0002697_abnormal_eye_size0.82585581
114MP0001348_abnormal_lacrimal_gland0.82090454
115MP0002132_abnormal_respiratory_system0.81696502
116MP0005551_abnormal_eye_electrophysiolog0.81692259
117MP0009840_abnormal_foam_cell0.81520780
118MP0000358_abnormal_cell_content/0.81490811
119MP0003806_abnormal_nucleotide_metabolis0.80225974
120MP0000537_abnormal_urethra_morphology0.79515396
121MP0002111_abnormal_tail_morphology0.79083466
122MP0000631_abnormal_neuroendocrine_gland0.78340961
123MP0002405_respiratory_system_inflammati0.76264458
124MP0003436_decreased_susceptibility_to0.76102113
125MP0002006_tumorigenesis0.76038339
126MP0002249_abnormal_larynx_morphology0.75740217
127MP0002452_abnormal_antigen_presenting0.75282398
128MP0002254_reproductive_system_inflammat0.75258783
129MP0002420_abnormal_adaptive_immunity0.73736533
130MP0004264_abnormal_extraembryonic_tissu0.73162320
131MP0003221_abnormal_cardiomyocyte_apopto0.72947789
132MP0001835_abnormal_antigen_presentation0.72861179
133MP0009703_decreased_birth_body0.72827627
134MP0001970_abnormal_pain_threshold0.72543239
135MP0001819_abnormal_immune_cell0.72204293
136MP0003941_abnormal_skin_development0.71898540
137MP0002723_abnormal_immune_serum0.71585502
138MP0003448_altered_tumor_morphology0.71278321
139MP0001661_extended_life_span0.71166006
140MP0000477_abnormal_intestine_morphology0.69575522
141MP0005257_abnormal_intraocular_pressure0.69330597
142MP0009931_abnormal_skin_appearance0.69227914
143MP0010155_abnormal_intestine_physiology0.67771060
144MP0000470_abnormal_stomach_morphology0.67534595
145MP0005671_abnormal_response_to0.67207757
146MP0005409_darkened_coat_color0.66121769
147MP0008995_early_reproductive_senescence0.65480573
148MP0002089_abnormal_postnatal_growth/wei0.65189051
149MP0008770_decreased_survivor_rate0.64983144
150MP0000653_abnormal_sex_gland0.64456810
151MP0001905_abnormal_dopamine_level0.63604987
152MP0010771_integument_phenotype0.62927553
153MP0003453_abnormal_keratinocyte_physiol0.62815390
154MP0010769_abnormal_survival0.62685243
155MP0010768_mortality/aging0.62405763
156MP0005646_abnormal_pituitary_gland0.62386622
157MP0006276_abnormal_autonomic_nervous0.61940019
158MP0000733_abnormal_muscle_development0.61883038
159MP0003937_abnormal_limbs/digits/tail_de0.61772110

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.46519945
2Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.23219549
3Ependymoma (HP:0002888)4.06434971
4Congenital stationary night blindness (HP:0007642)3.97533289
5Birth length less than 3rd percentile (HP:0003561)3.83382110
6Rectal fistula (HP:0100590)3.73220465
7Rectovaginal fistula (HP:0000143)3.73220465
8Intestinal fistula (HP:0100819)3.62969890
9Increased hepatocellular lipid droplets (HP:0006565)3.60313762
10Vaginal fistula (HP:0004320)3.54411523
11Lipid accumulation in hepatocytes (HP:0006561)3.50725933
12Dyschromatopsia (HP:0007641)3.28979392
13Renal Fanconi syndrome (HP:0001994)3.16502391
14Breast hypoplasia (HP:0003187)3.16006271
15Microvesicular hepatic steatosis (HP:0001414)3.15609936
16Mesangial abnormality (HP:0001966)3.13958849
17Selective tooth agenesis (HP:0001592)3.12107652
18Reticulocytopenia (HP:0001896)3.07415638
19Increased intramyocellular lipid droplets (HP:0012240)3.06142027
20Increased muscle lipid content (HP:0009058)2.97403520
21Patellar aplasia (HP:0006443)2.95652249
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95551493
23Attenuation of retinal blood vessels (HP:0007843)2.93972657
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91560430
25Chromsome breakage (HP:0040012)2.91461744
26Astrocytoma (HP:0009592)2.91429506
27Abnormality of the astrocytes (HP:0100707)2.91429506
28Impulsivity (HP:0100710)2.87283702
29Hypoplasia of the radius (HP:0002984)2.81901596
30Annular pancreas (HP:0001734)2.81152258
31Turricephaly (HP:0000262)2.80264281
32Rhabdomyosarcoma (HP:0002859)2.78993641
33Aplasia/Hypoplasia of the patella (HP:0006498)2.77473719
34Medulloblastoma (HP:0002885)2.76706028
35Short chin (HP:0000331)2.75560246
36Colon cancer (HP:0003003)2.73333663
37Facial hemangioma (HP:0000329)2.70992239
38Multiple enchondromatosis (HP:0005701)2.69090256
39Progressive microcephaly (HP:0000253)2.68351877
40Type I transferrin isoform profile (HP:0003642)2.68245623
41Mitochondrial inheritance (HP:0001427)2.67823437
42Carpal bone hypoplasia (HP:0001498)2.66646626
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60962389
44Abnormality of the labia minora (HP:0012880)2.59924369
45Abnormality of chromosome stability (HP:0003220)2.59030357
46Absent radius (HP:0003974)2.58864200
47Absent forearm bone (HP:0003953)2.55822980
48Aplasia involving forearm bones (HP:0009822)2.55822980
49Glioma (HP:0009733)2.54870947
50Bony spicule pigmentary retinopathy (HP:0007737)2.54459081
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53502932
52Abnormality of cells of the erythroid lineage (HP:0012130)2.52604221
53Rough bone trabeculation (HP:0100670)2.52334319
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52101128
55Poor head control (HP:0002421)2.50681602
56Basal cell carcinoma (HP:0002671)2.48980986
57Increased CSF lactate (HP:0002490)2.46811800
58Akinesia (HP:0002304)2.45289608
59Meckel diverticulum (HP:0002245)2.44827789
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.42602439
61Amniotic constriction ring (HP:0009775)2.42442215
62Abnormality of placental membranes (HP:0011409)2.42442215
63Respiratory difficulties (HP:0002880)2.40855340
64Oral leukoplakia (HP:0002745)2.40770305
65Agnosia (HP:0010524)2.39806640
66Proximal placement of thumb (HP:0009623)2.39361303
67Aplasia of the musculature (HP:0100854)2.38706590
68Abnormality of the ileum (HP:0001549)2.37697234
69Squamous cell carcinoma (HP:0002860)2.37101382
70Deviation of the thumb (HP:0009603)2.36035461
71Absent thumb (HP:0009777)2.35667552
72Neoplasm of the pancreas (HP:0002894)2.35028377
73Prominent nose (HP:0000448)2.31961795
74Hypoplasia of the pons (HP:0012110)2.31892383
75Neoplasm of striated muscle (HP:0009728)2.31206049
76Increased serum lactate (HP:0002151)2.30052583
77Pendular nystagmus (HP:0012043)2.29150372
78Abnormal number of incisors (HP:0011064)2.28084150
79Trismus (HP:0000211)2.27399736
80Hepatocellular necrosis (HP:0001404)2.27266306
81Myelodysplasia (HP:0002863)2.26438753
82Abnormality of the lower motor neuron (HP:0002366)2.24981886
83Abnormal number of erythroid precursors (HP:0012131)2.24584712
84Abnormality of the preputium (HP:0100587)2.24525183
85Sparse lateral eyebrow (HP:0005338)2.23458195
86Acute necrotizing encephalopathy (HP:0006965)2.22272060
87Abnormal mitochondria in muscle tissue (HP:0008316)2.21617527
88Premature graying of hair (HP:0002216)2.17697089
89Degeneration of anterior horn cells (HP:0002398)2.17541649
90Abnormality of the anterior horn cell (HP:0006802)2.17541649
91Cerebral hypomyelination (HP:0006808)2.16300007
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15101455
93Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15101455
94Deep palmar crease (HP:0006191)2.14389368
95Coronal craniosynostosis (HP:0004440)2.13802136
96Cafe-au-lait spot (HP:0000957)2.12832159
97Hyperthyroidism (HP:0000836)2.12507616
98IgM deficiency (HP:0002850)2.12165384
99Rib fusion (HP:0000902)2.12114298
100Premature ovarian failure (HP:0008209)2.11443585
101Reduced antithrombin III activity (HP:0001976)2.10850182
102Fetal akinesia sequence (HP:0001989)2.10267932
103Chorioretinal atrophy (HP:0000533)2.08923527
104Macrocytic anemia (HP:0001972)2.08546805
105Entropion (HP:0000621)2.08144190
106Thin bony cortex (HP:0002753)2.08001928
107Neoplasm of the oral cavity (HP:0100649)2.07591696
108Abnormality of the pons (HP:0007361)2.06729491
109Abnormality of the intrinsic pathway (HP:0010989)2.06594902
110Capillary hemangiomas (HP:0005306)2.05722943
111Aplasia/hypoplasia of the humerus (HP:0006507)2.05020122
112Abnormality of the fingertips (HP:0001211)2.04303760
113Anteriorly placed anus (HP:0001545)2.04181048
114Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02966974
1153-Methylglutaconic aciduria (HP:0003535)2.02274006
116Choanal stenosis (HP:0000452)2.01558743
117Cellular immunodeficiency (HP:0005374)2.01521578
118Bowed forearm bones (HP:0003956)2.01171708
119Bowing of the arm (HP:0006488)2.01171708
120Hypoalbuminemia (HP:0003073)2.00810723
121Abnormal albumin level (HP:0012116)2.00810723
122Pallor (HP:0000980)1.99595493
123Abnormality of small intestinal villus morphology (HP:0011472)1.99497271
124Villous atrophy (HP:0011473)1.99497271
125Missing ribs (HP:0000921)1.98368138
126Abnormal glycosylation (HP:0012345)1.97754556
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97754556
128Abnormal protein N-linked glycosylation (HP:0012347)1.97754556
129Abnormal protein glycosylation (HP:0012346)1.97754556
130Acute encephalopathy (HP:0006846)1.97231965
131Exercise intolerance (HP:0003546)1.96901652
132Tracheoesophageal fistula (HP:0002575)1.96756134
133Lymphoma (HP:0002665)1.94271427
134Progressive muscle weakness (HP:0003323)1.92230097
135Delayed epiphyseal ossification (HP:0002663)1.92072079
136Facial diplegia (HP:0001349)1.91709135
137Myotonia (HP:0002486)1.91165183
138Flat occiput (HP:0005469)1.90941358
139Lactic acidosis (HP:0003128)1.90163234
140Spina bifida occulta (HP:0003298)1.89930174
141Abnormality of the calcaneus (HP:0008364)1.89207333
142External ophthalmoplegia (HP:0000544)1.88787985
143Short thumb (HP:0009778)1.88579196
144Bone marrow hypocellularity (HP:0005528)1.88119326
145Myopathic facies (HP:0002058)1.88099317
146Overlapping toe (HP:0001845)1.88088668
147Small intestinal stenosis (HP:0012848)1.87803999
148Duodenal stenosis (HP:0100867)1.87803999
149Atresia of the external auditory canal (HP:0000413)1.87693916
150Prolonged partial thromboplastin time (HP:0003645)1.87680960
151Sloping forehead (HP:0000340)1.86564384
152T lymphocytopenia (HP:0005403)1.85353300
153Pustule (HP:0200039)1.85129124
154Increased nuchal translucency (HP:0010880)1.84616610
155Thrombocytosis (HP:0001894)1.84580055
156Preauricular skin tag (HP:0000384)1.83184905
157Poikiloderma (HP:0001029)1.82685555
158Long eyelashes (HP:0000527)1.82649230
159Secondary amenorrhea (HP:0000869)1.82153172
160Pelvic girdle muscle weakness (HP:0003749)1.81939755
161Skin tags (HP:0010609)1.81837799
162Short humerus (HP:0005792)1.81618120
163Gastrointestinal carcinoma (HP:0002672)1.79591724
164Malignant gastrointestinal tract tumors (HP:0006749)1.79591724
165Amaurosis fugax (HP:0100576)1.79157724
166IgG deficiency (HP:0004315)1.77525611
167Ectopic kidney (HP:0000086)1.77205600
16811 pairs of ribs (HP:0000878)1.77058076
169Ulnar bowing (HP:0003031)1.75886008
170Glossoptosis (HP:0000162)1.74208819
171Abnormality of T cell number (HP:0011839)1.72722351
172Abnormal trabecular bone morphology (HP:0100671)1.72607125
173Volvulus (HP:0002580)1.72590336
174Biliary tract neoplasm (HP:0100574)1.72261469
175Microretrognathia (HP:0000308)1.71883514
176Hypochromic anemia (HP:0001931)1.69786013
177Freckling (HP:0001480)1.68970383
178Acute lymphatic leukemia (HP:0006721)1.68813485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.01172600
2CDK123.96695896
3BUB13.90530964
4CDC73.18552440
5TAF13.17035598
6WEE13.08212076
7IRAK42.90892971
8NEK22.81660932
9EEF2K2.81526156
10SMG12.75955522
11WNK42.65940940
12VRK22.46137579
13TSSK62.26830236
14ACVR1B2.14430365
15TTK2.07140251
16MAP3K101.98145156
17EPHA21.94936687
18STK101.93589093
19CDK71.93333534
20SRPK11.90910332
21MAP4K11.89853869
22RPS6KB21.89708778
23STK161.87973752
24EIF2AK11.87714438
25PKN21.80516673
26ILK1.75671152
27PLK11.72862234
28BRAF1.69353900
29TESK21.62363769
30CDK41.58956024
31TLK11.58158046
32SIK21.54998599
33ZAK1.52708227
34GRK61.49449928
35ATR1.44309660
36NME11.43980121
37AURKB1.43468581
38CHEK11.41875123
39ALK1.40754233
40NEK11.38373048
41MAP3K81.35904428
42PLK41.35030966
43MAP2K61.33527472
44PIM11.32819798
45NME21.32222924
46RPS6KA41.31199556
47DYRK31.30651080
48CHEK21.27371488
49PASK1.26172128
50ERN11.23934349
51EIF2AK31.22614027
52PIM21.20210977
53ARAF1.16485461
54LATS11.12044158
55PRKD21.10055837
56LATS21.09245653
57STK31.07135876
58PAK41.03685939
59BRSK21.03499638
60BRD41.02734907
61CCNB11.00092819
62CDK20.99190768
63MTOR0.98983759
64SIK10.98968623
65PLK30.98307119
66IRAK30.95493632
67MKNK10.94256815
68MKNK20.94186803
69LRRK20.94002341
70AURKA0.91448082
71TRIB30.91072473
72FLT30.90987269
73ATM0.88787022
74CAMK1D0.88056149
75MAPKAPK30.82680654
76VRK10.82142176
77SCYL20.82020548
78CDK60.77333997
79PRKD30.77228039
80STK40.74591323
81ZAP700.74284333
82ICK0.73379454
83PAK20.72655076
84PRKCI0.71404318
85MAP3K110.71109408
86MAP2K20.67379593
87BLK0.66476860
88BRSK10.66351000
89CDK10.65976815
90PTK60.65712898
91JAK30.63278577
92CSNK2A20.62990221
93MUSK0.62800021
94CSF1R0.62440169
95DAPK10.62431963
96RPS6KA60.62003416
97DYRK20.61060051
98BCKDK0.60988453
99TYK20.60616162
100TGFBR10.59222404
101MAP2K30.59074010
102RPS6KL10.58753789
103RPS6KC10.58753789
104MAP2K70.58295930
105HIPK20.58044648
106AKT30.56992846
107MELK0.55161888
108KDR0.53939870
109MAPK120.53411046
110RPS6KA20.52138793
111PAK10.51792529
112CDK80.51532646
113RPS6KA10.50757401
114BTK0.49051105
115MARK30.48382461
116TAOK20.47875652
117IRAK20.47718585
118CSNK1E0.47287725
119RAF10.47078548
120MAPK80.46791602
121CDK11A0.46419662
122ABL20.44502928
123PRPF4B0.44347227
124CHUK0.44097028
125CSK0.43930133
126TAOK10.43810185
127AKT20.43585052
128GSK3B0.42894609
129RPS6KA50.42291020
130BMX0.41374700
131IKBKB0.41168815
132CSNK2A10.40310126
133TNK20.40216216
134PDPK10.39851907
135PDGFRA0.38080152
136STK38L0.38048178
137STK110.37509080
138CDK30.37354794
139CDK150.35541692
140FGFR10.35111039
141MAPK140.34441584
142AKT10.34180914
143MAP2K40.34053204
144MAPK110.33283379
145LCK0.33169642
146PRKDC0.33028449
147ITK0.32466736
148CSNK1D0.31726728

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15750108
2DNA replication_Homo sapiens_hsa030303.85984150
3Mismatch repair_Homo sapiens_hsa034303.43324694
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.39413450
5RNA transport_Homo sapiens_hsa030133.23763955
6Spliceosome_Homo sapiens_hsa030403.18767986
7One carbon pool by folate_Homo sapiens_hsa006702.99969580
8RNA polymerase_Homo sapiens_hsa030202.81217156
9Base excision repair_Homo sapiens_hsa034102.78617719
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.57810863
11Ribosome_Homo sapiens_hsa030102.56489679
12Oxidative phosphorylation_Homo sapiens_hsa001902.53959376
13Cell cycle_Homo sapiens_hsa041102.50892614
14Homologous recombination_Homo sapiens_hsa034402.42512361
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40693502
16Nucleotide excision repair_Homo sapiens_hsa034202.26115243
17Parkinsons disease_Homo sapiens_hsa050122.17104758
18Pyrimidine metabolism_Homo sapiens_hsa002401.94496161
19mRNA surveillance pathway_Homo sapiens_hsa030151.93028280
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92103903
21Fanconi anemia pathway_Homo sapiens_hsa034601.88240130
22p53 signaling pathway_Homo sapiens_hsa041151.86733661
23Huntingtons disease_Homo sapiens_hsa050161.86134585
24Non-homologous end-joining_Homo sapiens_hsa034501.81347517
25Proteasome_Homo sapiens_hsa030501.74614243
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65966040
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58372948
28RNA degradation_Homo sapiens_hsa030181.55162561
29Basal transcription factors_Homo sapiens_hsa030221.52463829
30Vitamin B6 metabolism_Homo sapiens_hsa007501.47222022
31Alzheimers disease_Homo sapiens_hsa050101.34940889
32Epstein-Barr virus infection_Homo sapiens_hsa051691.33366709
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31377286
34Primary immunodeficiency_Homo sapiens_hsa053401.27641110
35Viral carcinogenesis_Homo sapiens_hsa052031.25338537
36Systemic lupus erythematosus_Homo sapiens_hsa053221.25185750
37Selenocompound metabolism_Homo sapiens_hsa004501.20579382
38Sulfur relay system_Homo sapiens_hsa041221.18811950
39Herpes simplex infection_Homo sapiens_hsa051681.18503957
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15771935
41Antigen processing and presentation_Homo sapiens_hsa046121.14390669
42Pentose phosphate pathway_Homo sapiens_hsa000301.06882331
43Folate biosynthesis_Homo sapiens_hsa007901.02949280
44MicroRNAs in cancer_Homo sapiens_hsa052061.00379450
45Biosynthesis of amino acids_Homo sapiens_hsa012300.99373222
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.97602181
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.96703551
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95170958
49HTLV-I infection_Homo sapiens_hsa051660.91611831
50Nicotine addiction_Homo sapiens_hsa050330.89116464
51Small cell lung cancer_Homo sapiens_hsa052220.89097779
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85301520
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84165196
54Cardiac muscle contraction_Homo sapiens_hsa042600.84046523
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83173013
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.82813862
57Purine metabolism_Homo sapiens_hsa002300.80031696
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79847844
59mTOR signaling pathway_Homo sapiens_hsa041500.77986028
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77140761
61Measles_Homo sapiens_hsa051620.76288994
62Chronic myeloid leukemia_Homo sapiens_hsa052200.73614402
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72920500
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72238451
65Sphingolipid metabolism_Homo sapiens_hsa006000.72126668
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.71882930
67Apoptosis_Homo sapiens_hsa042100.71369178
68Pyruvate metabolism_Homo sapiens_hsa006200.70084214
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68382615
70Notch signaling pathway_Homo sapiens_hsa043300.68185732
71Acute myeloid leukemia_Homo sapiens_hsa052210.67393249
72Hedgehog signaling pathway_Homo sapiens_hsa043400.67195618
73Colorectal cancer_Homo sapiens_hsa052100.64295938
74Sulfur metabolism_Homo sapiens_hsa009200.63822664
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63696323
76T cell receptor signaling pathway_Homo sapiens_hsa046600.63246598
77Vitamin digestion and absorption_Homo sapiens_hsa049770.63021387
78Hepatitis B_Homo sapiens_hsa051610.62280367
79Lysine degradation_Homo sapiens_hsa003100.62056414
80Legionellosis_Homo sapiens_hsa051340.61997902
81Metabolic pathways_Homo sapiens_hsa011000.61900559
82B cell receptor signaling pathway_Homo sapiens_hsa046620.61646384
83Oocyte meiosis_Homo sapiens_hsa041140.60836972
84Thyroid cancer_Homo sapiens_hsa052160.60169044
85Alcoholism_Homo sapiens_hsa050340.59332342
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57827057
87Viral myocarditis_Homo sapiens_hsa054160.56333786
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.55816072
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.54251555
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53523165
91Fatty acid elongation_Homo sapiens_hsa000620.52990724
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48593541
93Phototransduction_Homo sapiens_hsa047440.48119876
94Taste transduction_Homo sapiens_hsa047420.46039781
95Influenza A_Homo sapiens_hsa051640.45539434
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45212555
97Hippo signaling pathway_Homo sapiens_hsa043900.44664350
98Hematopoietic cell lineage_Homo sapiens_hsa046400.44574787
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44300041
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.41312993
101Bladder cancer_Homo sapiens_hsa052190.41241452
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39056398
103Shigellosis_Homo sapiens_hsa051310.38453560
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38073780
105Glutathione metabolism_Homo sapiens_hsa004800.37750090
106Prostate cancer_Homo sapiens_hsa052150.36932524
107TGF-beta signaling pathway_Homo sapiens_hsa043500.36767602
108Allograft rejection_Homo sapiens_hsa053300.36641084
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35164296
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35010458
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33919186
112Pancreatic cancer_Homo sapiens_hsa052120.33019278
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32944720
114Adherens junction_Homo sapiens_hsa045200.31824782
115Leishmaniasis_Homo sapiens_hsa051400.31066476
116Basal cell carcinoma_Homo sapiens_hsa052170.30780425
117Pathways in cancer_Homo sapiens_hsa052000.30282409
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30254452
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30152586
120HIF-1 signaling pathway_Homo sapiens_hsa040660.29989110
121Non-small cell lung cancer_Homo sapiens_hsa052230.29911790
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28859124
123Toxoplasmosis_Homo sapiens_hsa051450.28693396
124FoxO signaling pathway_Homo sapiens_hsa040680.28460123
125Melanoma_Homo sapiens_hsa052180.27295018
126Arginine and proline metabolism_Homo sapiens_hsa003300.26129180
127Endometrial cancer_Homo sapiens_hsa052130.26013230
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.25040431
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25035382
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24653991
131Carbon metabolism_Homo sapiens_hsa012000.24275877
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.24119507
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23752961
134Regulation of autophagy_Homo sapiens_hsa041400.23443155
135N-Glycan biosynthesis_Homo sapiens_hsa005100.23394939
136Fructose and mannose metabolism_Homo sapiens_hsa000510.21824555
137Proteoglycans in cancer_Homo sapiens_hsa052050.21640991
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19708155
139AMPK signaling pathway_Homo sapiens_hsa041520.18305911
140VEGF signaling pathway_Homo sapiens_hsa043700.18043597
141Synaptic vesicle cycle_Homo sapiens_hsa047210.15013151
142Cocaine addiction_Homo sapiens_hsa050300.13210669
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10611544

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »