SUSD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.17164621
2regulation of water loss via skin (GO:0033561)7.51273231
3cellular response to nitric oxide (GO:0071732)6.17411268
4keratinization (GO:0031424)6.08038208
5neurofilament cytoskeleton organization (GO:0060052)5.76541895
6intermediate filament organization (GO:0045109)5.69026324
7NADH metabolic process (GO:0006734)5.68238310
8multicellular organismal water homeostasis (GO:0050891)5.57107989
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.38382099
10sphingoid metabolic process (GO:0046519)5.09182604
11nonribosomal peptide biosynthetic process (GO:0019184)4.78130611
12glutathione biosynthetic process (GO:0006750)4.78107803
13water homeostasis (GO:0030104)4.77408919
14sphingosine metabolic process (GO:0006670)4.66739633
15keratinocyte proliferation (GO:0043616)4.59985946
16cellular response to reactive nitrogen species (GO:1902170)4.47116527
17keratinocyte differentiation (GO:0030216)4.44116269
18hemidesmosome assembly (GO:0031581)4.40564009
19response to nitric oxide (GO:0071731)4.35774172
20regulation of ruffle assembly (GO:1900027)4.31067644
21diol metabolic process (GO:0034311)4.29021675
22phospholipid scrambling (GO:0017121)4.23427335
23angiotensin maturation (GO:0002003)4.15063791
24drug transmembrane transport (GO:0006855)4.13220887
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.10990210
26detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.96659192
27detection of temperature stimulus involved in sensory perception (GO:0050961)3.96659192
28detection of temperature stimulus (GO:0016048)3.88317585
29epoxygenase P450 pathway (GO:0019373)3.87958105
30intermediate filament cytoskeleton organization (GO:0045104)3.86818034
31peptide cross-linking (GO:0018149)3.84434311
32long-chain fatty acid biosynthetic process (GO:0042759)3.81921303
33intermediate filament-based process (GO:0045103)3.79772891
34response to vitamin A (GO:0033189)3.76576877
35amyloid precursor protein metabolic process (GO:0042982)3.74990855
36negative regulation of T cell differentiation in thymus (GO:0033085)3.74149406
37protein retention in ER lumen (GO:0006621)3.72370727
38fatty acid elongation (GO:0030497)3.66571859
39organic cation transport (GO:0015695)3.66337341
40urate metabolic process (GO:0046415)3.65672474
41positive regulation of glomerulus development (GO:0090193)3.61535958
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60738248
43response to water (GO:0009415)3.59841429
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.51754833
45epidermal cell differentiation (GO:0009913)3.51054949
46positive regulation of Cdc42 GTPase activity (GO:0043089)3.48064812
47regulation of G0 to G1 transition (GO:0070316)3.44978493
48calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.44205023
49epithelial cell-cell adhesion (GO:0090136)3.40655249
50glycosphingolipid catabolic process (GO:0046479)3.37975717
51cell communication involved in cardiac conduction (GO:0086065)3.37457979
52vitamin transmembrane transport (GO:0035461)3.36571413
53Golgi transport vesicle coating (GO:0048200)3.34734125
54COPI coating of Golgi vesicle (GO:0048205)3.34734125
55peptide biosynthetic process (GO:0043043)3.32652431
56protein autoprocessing (GO:0016540)3.32180151
57drug catabolic process (GO:0042737)3.31995954
58aminoglycoside antibiotic metabolic process (GO:0030647)3.31454478
59membrane budding (GO:0006900)3.30793988
60drug transport (GO:0015893)3.28332853
61exogenous drug catabolic process (GO:0042738)3.26799480
62regulation of cholesterol esterification (GO:0010872)3.25543761
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.22894570
64response to thyroid hormone (GO:0097066)3.21548301
65sexual reproduction (GO:0019953)3.20270226
66glycolipid catabolic process (GO:0019377)3.18917252
67virion attachment to host cell (GO:0019062)3.16391128
68adhesion of symbiont to host cell (GO:0044650)3.16391128
69adhesion of symbiont to host (GO:0044406)3.14976934
70prostaglandin biosynthetic process (GO:0001516)3.14624001
71prostanoid biosynthetic process (GO:0046457)3.14624001
72regulation of hippo signaling (GO:0035330)3.13777493
73quaternary ammonium group transport (GO:0015697)3.11514663
74glucosamine-containing compound catabolic process (GO:1901072)3.10421677
75negative regulation of dendrite morphogenesis (GO:0050774)3.08631389
76proline metabolic process (GO:0006560)3.06071444
77urea cycle (GO:0000050)3.05658462
78flavonoid metabolic process (GO:0009812)3.04908081
79very-low-density lipoprotein particle assembly (GO:0034379)3.04715962
80epidermis development (GO:0008544)3.03336511
81regulation of phospholipase A2 activity (GO:0032429)3.01717313
82proline biosynthetic process (GO:0006561)2.98695535
83regulation of transforming growth factor beta1 production (GO:0032908)2.98518779
84regulation of cell proliferation involved in kidney development (GO:1901722)2.98396411
85renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.97436620
86GDP-mannose metabolic process (GO:0019673)2.97145976
87sodium ion export (GO:0071436)2.95170548
88phenylpropanoid metabolic process (GO:0009698)2.95076494
89response to phenylpropanoid (GO:0080184)2.93391938
90calcium-mediated signaling using intracellular calcium source (GO:0035584)2.90393627
91hormone catabolic process (GO:0042447)2.88053975
92positive regulation of epidermal cell differentiation (GO:0045606)2.87731866
93plasma lipoprotein particle assembly (GO:0034377)2.87717021
94regulation of cardioblast differentiation (GO:0051890)2.87413084
95branching involved in salivary gland morphogenesis (GO:0060445)2.87372992
96toxin metabolic process (GO:0009404)2.87280977
97phospholipid efflux (GO:0033700)2.87233081
98regulation of cholesterol metabolic process (GO:0090181)2.86751111
99norepinephrine metabolic process (GO:0042415)2.86360252
100fat-soluble vitamin biosynthetic process (GO:0042362)2.85037299
1014-hydroxyproline metabolic process (GO:0019471)2.84968172
102negative regulation of lipase activity (GO:0060192)2.83735221
103atrioventricular valve morphogenesis (GO:0003181)2.82800285
104phosphate ion transmembrane transport (GO:0035435)2.82410062
105chemical homeostasis within a tissue (GO:0048875)2.81853505
106protein maturation by protein folding (GO:0022417)2.81134814
107embryonic process involved in female pregnancy (GO:0060136)2.80982491
108positive regulation of keratinocyte differentiation (GO:0045618)2.80798513
109phosphate ion transport (GO:0006817)2.80494527
110glutamine family amino acid biosynthetic process (GO:0009084)2.78731403
111negative regulation of keratinocyte proliferation (GO:0010839)2.78118878
112plasma membrane repair (GO:0001778)2.77476043
113urea metabolic process (GO:0019627)2.76985587
114regulation of cholesterol biosynthetic process (GO:0045540)2.76946404
115lipoprotein transport (GO:0042953)2.76767781
116lysine catabolic process (GO:0006554)2.76533696
117lysine metabolic process (GO:0006553)2.76533696
118positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75877599
119amyloid precursor protein catabolic process (GO:0042987)2.75201632
120drug metabolic process (GO:0017144)2.74784167
121detection of bacterium (GO:0016045)2.74393945
122positive regulation of vesicle fusion (GO:0031340)2.72395698
123long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.69254170
124cell migration in hindbrain (GO:0021535)2.69127163
125fructose metabolic process (GO:0006000)2.68484498
126excretion (GO:0007588)2.68047805
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68047305
128tight junction assembly (GO:0070830)2.67709256
129cellular response to thyroid hormone stimulus (GO:0097067)2.67562094
130interferon-gamma secretion (GO:0072643)2.64518291
131response to copper ion (GO:0046688)2.64496481
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64400037
133apoptotic process involved in morphogenesis (GO:0060561)2.63974906
134positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.62406827
135regulation of bile acid biosynthetic process (GO:0070857)2.62250137
136negative regulation of complement activation (GO:0045916)2.61971128
137regulation of glomerulus development (GO:0090192)2.60961126
138ceramide catabolic process (GO:0046514)2.60296753
139renal absorption (GO:0070293)2.59945641
140renal system process involved in regulation of blood volume (GO:0001977)2.58872244
141phosphate ion homeostasis (GO:0055062)2.58338671
142trivalent inorganic anion homeostasis (GO:0072506)2.58338671
143positive regulation of cellular amine metabolic process (GO:0033240)2.57024653
144adherens junction assembly (GO:0034333)2.57016719
145negative regulation of kidney development (GO:0090185)2.56375324
146transepithelial transport (GO:0070633)2.56186588
147fatty acid derivative transport (GO:1901571)2.55753985
148icosanoid transport (GO:0071715)2.55753985
149regulation of glomerular filtration (GO:0003093)2.55492898
150membrane raft organization (GO:0031579)2.52175382
151ectoderm development (GO:0007398)2.51899446
152cysteine metabolic process (GO:0006534)2.51384081
153cellular potassium ion homeostasis (GO:0030007)2.51328473
154peripheral nervous system neuron development (GO:0048935)2.50312235
155hydrogen peroxide biosynthetic process (GO:0050665)2.50297642
156sphingomyelin metabolic process (GO:0006684)2.49970974
157carnitine transport (GO:0015879)2.49773619
158amino-acid betaine transport (GO:0015838)2.49773619
159protein-lipid complex assembly (GO:0065005)2.48796612
160omega-hydroxylase P450 pathway (GO:0097267)2.48490844
161surfactant homeostasis (GO:0043129)2.46821258
162molting cycle (GO:0042303)2.45503429
163hair cycle (GO:0042633)2.45503429
164neuronal action potential (GO:0019228)2.43417019
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.41605523
166beta-amyloid metabolic process (GO:0050435)2.40601484
167peptide catabolic process (GO:0043171)2.39872383
168cellular modified amino acid catabolic process (GO:0042219)2.37365426
169sodium ion transport (GO:0006814)2.35687235
170fatty-acyl-CoA metabolic process (GO:0035337)2.34726902
171very long-chain fatty acid metabolic process (GO:0000038)2.34677063
172positive regulation of interleukin-8 secretion (GO:2000484)2.33936129
173sodium ion homeostasis (GO:0055078)2.31782852
174sympathetic nervous system development (GO:0048485)2.31422743
175glutathione metabolic process (GO:0006749)2.31272869
176regulation of clathrin-mediated endocytosis (GO:2000369)2.31129243
177skin morphogenesis (GO:0043589)2.30807475
178vitamin D metabolic process (GO:0042359)2.28441559
179lipoxygenase pathway (GO:0019372)2.28178168
180sodium-independent organic anion transport (GO:0043252)2.27680621
181response to mercury ion (GO:0046689)2.27361270
182regulation of cholesterol homeostasis (GO:2000188)2.25951694
183regulation of heart rate by cardiac conduction (GO:0086091)2.24861486
184sodium ion transmembrane transport (GO:0035725)2.23955564
185desmosome organization (GO:0002934)10.4031345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.57914697
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.67293959
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.47700789
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.78880583
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.62955570
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53827173
7ZNF263_19887448_ChIP-Seq_K562_Human2.19320265
8CLOCK_20551151_ChIP-Seq_293T_Human2.18340180
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.07377518
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.06940535
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.06323640
12ELK3_25401928_ChIP-Seq_HUVEC_Human1.95376435
13* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.92738523
14TET1_21451524_ChIP-Seq_MESCs_Mouse1.85406948
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71288613
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70299412
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62040872
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58958300
19SMC4_20622854_ChIP-Seq_HELA_Human1.55514171
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53953096
21UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52822571
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.52358407
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51850972
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51848879
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51388128
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51036521
27TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50982154
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50779107
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.50700203
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50595313
31SOX2_20726797_ChIP-Seq_SW620_Human1.49866069
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49695674
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48849081
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48849081
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47257921
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44955456
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43027152
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42200680
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41782244
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41625619
41VDR_22108803_ChIP-Seq_LS180_Human1.40750624
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40380618
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39292886
44CREB1_26743006_Chip-Seq_LNCaP_Human1.37476077
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36508389
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.35042334
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34558355
48AHR_22903824_ChIP-Seq_MCF-7_Human1.33814372
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33480724
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33128621
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32594040
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32442315
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32400114
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32346204
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32117314
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31435137
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.31426949
58TP63_23658742_ChIP-Seq_EP156T_Human1.31193069
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29750003
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29557466
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.28897461
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27962938
63CTCF_27219007_Chip-Seq_Bcells_Human1.27335681
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24887980
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.22895255
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21988836
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.20903199
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.20321756
69TP63_22573176_ChIP-Seq_HFKS_Human1.20104529
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.19935389
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19931325
72BCAT_22108803_ChIP-Seq_LS180_Human1.17636005
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17432773
74* CJUN_26792858_Chip-Seq_BT549_Human1.17128533
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16620612
76RACK7_27058665_Chip-Seq_MCF-7_Human1.16490840
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16307614
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.16218932
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16113305
80AR_21909140_ChIP-Seq_LNCAP_Human1.14161328
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.13995702
82P68_20966046_ChIP-Seq_HELA_Human1.13573106
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13041253
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12628526
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12418822
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12418822
87BCOR_27268052_Chip-Seq_Bcells_Human1.12355032
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10409616
89KLF5_25053715_ChIP-Seq_YYC3_Human1.06892617
90TP53_18474530_ChIP-ChIP_U2OS_Human1.06814085
91RXR_22108803_ChIP-Seq_LS180_Human1.05795819
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05014439
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.04566214
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04211398
95GATA4_25053715_ChIP-Seq_YYC3_Human1.02894596
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02207063
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.02198159
98* LXR_22292898_ChIP-Seq_THP-1_Human1.01223396
99EGR1_19032775_ChIP-ChIP_M12_Human1.01155929
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00661806
101* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00619318
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00338504
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99504539
104* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99487664
105* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99487664
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99342818
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99140847
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.99016239
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.98583191
110ETS1_21867929_ChIP-Seq_TH2_Mouse0.98397983
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97878086
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97646446
113TP53_22127205_ChIP-Seq_IMR90_Human0.97099508
114* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95837172
115KDM2B_26808549_Chip-Seq_K562_Human0.94971443
116AR_21572438_ChIP-Seq_LNCaP_Human0.94448768
117TCF4_22108803_ChIP-Seq_LS180_Human0.93701308
118GATA3_24758297_ChIP-Seq_MCF-7_Human0.91830892
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.91830623
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.91774286
121PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90785316
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90695012
123GATA6_25053715_ChIP-Seq_YYC3_Human0.90492396
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90485773
125ATF3_27146783_Chip-Seq_COLON_Human0.90148839
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88815749
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88087199
128* SA1_27219007_Chip-Seq_ERYTHROID_Human0.87568063
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86765772
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86157411
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85115554
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83330524
133TAF15_26573619_Chip-Seq_HEK293_Human0.83012509
134* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82535200
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82401904
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81925116
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80004027
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.79779611
139SA1_27219007_Chip-Seq_Bcells_Human0.79642363
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78286597
141* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77995796
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76271716
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76271716
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76271716
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75943372
146* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75504095
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74756012
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73399686
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72638920
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.71396868
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71240368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.31948124
2MP0010234_abnormal_vibrissa_follicle4.96468914
3MP0003941_abnormal_skin_development4.73982806
4MP0005501_abnormal_skin_physiology4.37679977
5MP0005275_abnormal_skin_tensile4.31358297
6MP0009840_abnormal_foam_cell3.94649291
7MP0002735_abnormal_chemical_nociception3.24591628
8MP0004858_abnormal_nervous_system3.00146039
9MP0010771_integument_phenotype2.86800075
10MP0004381_abnormal_hair_follicle2.71427047
11MP0002254_reproductive_system_inflammat2.68318678
12MP0001216_abnormal_epidermal_layer2.65513869
13MP0005360_urolithiasis2.58574152
14MP0002060_abnormal_skin_morphology2.50003341
15MP0005058_abnormal_lysosome_morphology2.40997451
16MP0000579_abnormal_nail_morphology2.38542292
17MP0005451_abnormal_body_composition2.36295735
18MP0009780_abnormal_chondrocyte_physiolo2.28002144
19MP0004019_abnormal_vitamin_homeostasis2.26778437
20MP0001968_abnormal_touch/_nociception2.25789143
21MP0002736_abnormal_nociception_after2.16966896
22MP0002098_abnormal_vibrissa_morphology2.09327867
23MP0003453_abnormal_keratinocyte_physiol2.07439961
24MP0008995_early_reproductive_senescence2.02497799
25MP0003806_abnormal_nucleotide_metabolis1.89991256
26MP0004270_analgesia1.88996582
27MP0006276_abnormal_autonomic_nervous1.86799311
28MP0000678_abnormal_parathyroid_gland1.76961498
29MP0010678_abnormal_skin_adnexa1.75719702
30MP0002733_abnormal_thermal_nociception1.74834365
31MP0004947_skin_inflammation1.74354631
32MP0000377_abnormal_hair_follicle1.72325942
33MP0005365_abnormal_bile_salt1.69572580
34MP0002009_preneoplasia1.67056312
35MP0001765_abnormal_ion_homeostasis1.65062483
36MP0000538_abnormal_urinary_bladder1.64961512
37MP0003705_abnormal_hypodermis_morpholog1.62680704
38MP0005409_darkened_coat_color1.60426381
39MP0000383_abnormal_hair_follicle1.60311182
40MP0005330_cardiomyopathy1.57793208
41MP0000427_abnormal_hair_cycle1.54689634
42MP0003566_abnormal_cell_adhesion1.54098362
43MP0000647_abnormal_sebaceous_gland1.52899449
44MP0004043_abnormal_pH_regulation1.50645219
45MP0003091_abnormal_cell_migration1.49448024
46MP0000566_synostosis1.47463215
47MP0000462_abnormal_digestive_system1.45000007
48MP0005023_abnormal_wound_healing1.44960979
49MP0000467_abnormal_esophagus_morphology1.43661572
50MP0005388_respiratory_system_phenotype1.37463400
51MP0002133_abnormal_respiratory_system1.37463400
52MP0005332_abnormal_amino_acid1.36330635
53MP0000762_abnormal_tongue_morphology1.36263785
54MP0002734_abnormal_mechanical_nocicepti1.34629545
55MP0003329_amyloid_beta_deposits1.34022737
56MP0001191_abnormal_skin_condition1.33010695
57MP0009643_abnormal_urine_homeostasis1.32848677
58MP0005670_abnormal_white_adipose1.32064752
59MP0005257_abnormal_intraocular_pressure1.31906894
60MP0002295_abnormal_pulmonary_circulatio1.30332094
61MP0001970_abnormal_pain_threshold1.30252247
62MP0010030_abnormal_orbit_morphology1.26991946
63MP0009931_abnormal_skin_appearance1.26472920
64MP0005076_abnormal_cell_differentiation1.25761713
65MP0001756_abnormal_urination1.25159117
66MP0003191_abnormal_cellular_cholesterol1.22862989
67MP0008961_abnormal_basal_metabolism1.19233855
68MP0004233_abnormal_muscle_weight1.17500665
69MP0005636_abnormal_mineral_homeostasis1.14288155
70MP0006138_congestive_heart_failure1.14241022
71MP0008260_abnormal_autophagy1.11658561
72MP0001346_abnormal_lacrimal_gland1.11627262
73MP0005083_abnormal_biliary_tract1.07934294
74MP0002909_abnormal_adrenal_gland1.07215215
75MP0004185_abnormal_adipocyte_glucose1.02021611
76MP0008438_abnormal_cutaneous_collagen1.01109609
77MP0001986_abnormal_taste_sensitivity1.00709743
78MP0002136_abnormal_kidney_physiology0.99319472
79MP0000750_abnormal_muscle_regeneration0.97802157
80MP0000367_abnormal_coat/_hair0.97240668
81MP0002089_abnormal_postnatal_growth/wei0.96746693
82MP0001849_ear_inflammation0.96626329
83MP0003879_abnormal_hair_cell0.96346770
84MP0001958_emphysema0.95381963
85MP0002822_catalepsy0.95277413
86MP0001661_extended_life_span0.93393889
87MP0001666_abnormal_nutrient_absorption0.92393607
88MP0005584_abnormal_enzyme/coenzyme_acti0.91822892
89MP0010386_abnormal_urinary_bladder0.91209779
90MP0005085_abnormal_gallbladder_physiolo0.90835358
91MP0008875_abnormal_xenobiotic_pharmacok0.90411656
92MP0002139_abnormal_hepatobiliary_system0.90018103
93MP0000627_abnormal_mammary_gland0.89349325
94MP0003315_abnormal_perineum_morphology0.88950719
95MP0009379_abnormal_foot_pigmentation0.88890181
96MP0010329_abnormal_lipoprotein_level0.88521152
97MP0009046_muscle_twitch0.87266876
98MP0002118_abnormal_lipid_homeostasis0.87219740
99MP0003195_calcinosis0.86025175
100MP0004036_abnormal_muscle_relaxation0.85896950
101MP0003950_abnormal_plasma_membrane0.83184025
102MP0001177_atelectasis0.82681211
103MP0001340_abnormal_eyelid_morphology0.82117768
104MP0003638_abnormal_response/metabolism_0.81683334
105MP0000477_abnormal_intestine_morphology0.80560940
106MP0003718_maternal_effect0.79614083
107MP0002108_abnormal_muscle_morphology0.78633895
108MP0001270_distended_abdomen0.77947740
109MP0001984_abnormal_olfaction0.77855708
110MP0000858_altered_metastatic_potential0.76449893
111MP0004084_abnormal_cardiac_muscle0.76435025
112MP0003786_premature_aging0.76163095
113MP0004264_abnormal_extraembryonic_tissu0.75804559
114MP0010368_abnormal_lymphatic_system0.74548240
115MP0004272_abnormal_basement_membrane0.72960999
116MP0009333_abnormal_splenocyte_physiolog0.72860918
117MP0002184_abnormal_innervation0.72026761
118MP0003878_abnormal_ear_physiology0.70376945
119MP0005377_hearing/vestibular/ear_phenot0.70376945
120MP0004147_increased_porphyrin_level0.70116312
121MP0003115_abnormal_respiratory_system0.68141791
122MP0004782_abnormal_surfactant_physiolog0.67317842
123MP0000249_abnormal_blood_vessel0.66684812
124MP0002086_abnormal_extraembryonic_tissu0.66334278
125MP0000609_abnormal_liver_physiology0.65987653
126MP0001175_abnormal_lung_morphology0.65948370
127MP0005319_abnormal_enzyme/_coenzyme0.65931489
128MP0001881_abnormal_mammary_gland0.65360910
129MP0001730_embryonic_growth_arrest0.64674178
130MP0000681_abnormal_thyroid_gland0.62296159
131MP0003866_abnormal_defecation0.61427487
132MP0001243_abnormal_dermal_layer0.61363950
133MP0002067_abnormal_sensory_capabilities0.60288998
134MP0000013_abnormal_adipose_tissue0.60225169
135MP0002751_abnormal_autonomic_nervous0.59655607
136MP0002876_abnormal_thyroid_physiology0.59465536
137MP0000372_irregular_coat_pigmentation0.57527815
138MP0001348_abnormal_lacrimal_gland0.57448507
139MP0008004_abnormal_stomach_pH0.57372685
140MP0000516_abnormal_urinary_system0.54346101
141MP0005367_renal/urinary_system_phenotyp0.54346101
142MP0000747_muscle_weakness0.52826780
143MP0000604_amyloidosis0.52720536
144MP0000751_myopathy0.52655638
145MP0010352_gastrointestinal_tract_polyps0.52448876
146MP0000534_abnormal_ureter_morphology0.51917273
147MP0001542_abnormal_bone_strength0.51902833
148MP0000537_abnormal_urethra_morphology0.51271236
149MP0003045_fibrosis0.51144651
150MP0003183_abnormal_peptide_metabolism0.50330141
151MP0000230_abnormal_systemic_arterial0.50161559
152MP0002896_abnormal_bone_mineralization0.48382529
153MP0001851_eye_inflammation0.46560909
154MP0004885_abnormal_endolymph0.46519995
155MP0001664_abnormal_digestion0.43400792
156MP0008874_decreased_physiological_sensi0.40983128

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)9.94216329
2Ulnar claw (HP:0001178)5.74200795
3Hypotrichosis (HP:0001006)5.21530199
4Congenital ichthyosiform erythroderma (HP:0007431)4.88008872
5Parakeratosis (HP:0001036)4.68028331
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.54540663
7Lip pit (HP:0100267)4.25147606
8Right ventricular cardiomyopathy (HP:0011663)4.10810178
9Hypomagnesemia (HP:0002917)3.95781404
10Ependymoma (HP:0002888)3.84308117
11Plantar hyperkeratosis (HP:0007556)3.81030901
12Palmoplantar hyperkeratosis (HP:0000972)3.77145496
13Woolly hair (HP:0002224)3.74618338
14Increased IgE level (HP:0003212)3.70536005
15Hypokalemic alkalosis (HP:0001949)3.70481929
16Distal lower limb muscle weakness (HP:0009053)3.66959711
17Hyperactive renin-angiotensin system (HP:0000841)3.65947882
18Popliteal pterygium (HP:0009756)3.55517348
19Erythema (HP:0010783)3.53975606
20Hyporeflexia of lower limbs (HP:0002600)3.53267832
21Increased circulating renin level (HP:0000848)3.52621046
22Gout (HP:0001997)3.51320262
23Segmental peripheral demyelination/remyelination (HP:0003481)3.51045171
24Abnormality of magnesium homeostasis (HP:0004921)3.46131413
25Systemic lupus erythematosus (HP:0002725)3.44546996
26Palmar hyperkeratosis (HP:0010765)3.42039448
27Conjunctival hamartoma (HP:0100780)3.40940530
28Abnormality of nail color (HP:0100643)3.39403335
29Metabolic alkalosis (HP:0200114)3.37259938
30Abnormality of chloride homeostasis (HP:0011422)3.32302792
31Alveolar cell carcinoma (HP:0006519)3.17024690
32Respiratory distress (HP:0002098)3.13824528
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06326066
34Corneal erosion (HP:0200020)3.04951704
35Natal tooth (HP:0000695)3.00834353
36Advanced eruption of teeth (HP:0006288)2.99867046
37Abnormality of the distal phalanges of the toes (HP:0010182)2.97138577
38Pili torti (HP:0003777)2.91470840
39Abnormal hemoglobin (HP:0011902)2.89430272
40Distal lower limb amyotrophy (HP:0008944)2.83547247
41Fragile nails (HP:0001808)2.82078484
42Erythroderma (HP:0001019)2.80235160
43Dehydration (HP:0001944)2.78397842
44Ventricular fibrillation (HP:0001663)2.74642044
45Abnormality of renal excretion (HP:0011036)2.73688147
46Neoplasm of the tracheobronchial system (HP:0100552)2.72855173
47Polyuria (HP:0000103)2.70602418
48Hypokinesia (HP:0002375)2.70151865
49Vertebral compression fractures (HP:0002953)2.69361259
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68311888
51Hydroxyprolinuria (HP:0003080)2.64347737
52Abnormality of proline metabolism (HP:0010907)2.64347737
53Abnormal urine output (HP:0012590)2.63828398
54Curly hair (HP:0002212)2.60780025
55Steppage gait (HP:0003376)2.59852587
56Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.59730306
57Mitral stenosis (HP:0001718)2.56409617
58Vascular calcification (HP:0004934)2.52840471
59Nail dystrophy (HP:0008404)2.52631094
60Amelogenesis imperfecta (HP:0000705)2.50408990
61Tachypnea (HP:0002789)2.49463141
62Renal salt wasting (HP:0000127)2.49410179
63Proximal tubulopathy (HP:0000114)2.48710479
64Onycholysis (HP:0001806)2.48123655
65Astrocytoma (HP:0009592)2.47700926
66Abnormality of the astrocytes (HP:0100707)2.47700926
67Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.46303925
68Abdominal distention (HP:0003270)2.44613038
69Xanthomatosis (HP:0000991)2.43311157
70Areflexia of lower limbs (HP:0002522)2.42766954
71Abnormality of secondary sexual hair (HP:0009888)2.42094624
72Abnormality of the axillary hair (HP:0100134)2.42094624
73Abnormal blistering of the skin (HP:0008066)2.41196802
74Myokymia (HP:0002411)2.40209919
75Hypohidrosis (HP:0000966)2.37327863
76Stomach cancer (HP:0012126)2.34431898
77Hyperglycinuria (HP:0003108)2.33484751
78Glomerulonephritis (HP:0000099)2.32282520
79Trismus (HP:0000211)2.32115251
80Seborrheic dermatitis (HP:0001051)2.30734057
81Foot dorsiflexor weakness (HP:0009027)2.29341423
82Growth hormone excess (HP:0000845)2.28413056
83Abnormality of renin-angiotensin system (HP:0000847)2.26784001
84Alkalosis (HP:0001948)2.26198916
85Abnormal hair laboratory examination (HP:0003328)2.25616853
86Down-sloping shoulders (HP:0200021)2.25609011
87Sparse scalp hair (HP:0002209)2.22541723
88Hyperaldosteronism (HP:0000859)2.21851621
89Malnutrition (HP:0004395)2.21404808
90Premature rupture of membranes (HP:0001788)2.20773364
91Abnormality of the vocal cords (HP:0008777)2.20666336
92Cardiovascular calcification (HP:0011915)2.19727909
93Increased purine levels (HP:0004368)2.19594998
94Hyperuricemia (HP:0002149)2.19594998
95Abnormality of complement system (HP:0005339)2.18962984
96Adrenal overactivity (HP:0002717)2.16644607
97Hypobetalipoproteinemia (HP:0003563)2.15650847
98Facial shape deformation (HP:0011334)2.13723940
99Potter facies (HP:0002009)2.13723940
100Widely patent fontanelles and sutures (HP:0004492)2.13337133
101Increased connective tissue (HP:0009025)2.13056288
102Wide cranial sutures (HP:0010537)2.13016243
103Severe Myopia (HP:0011003)2.12508356
104Acanthosis nigricans (HP:0000956)2.12337845
105Abnormality of glycolipid metabolism (HP:0010969)2.11447776
106Abnormality of liposaccharide metabolism (HP:0010968)2.11447776
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.11447776
108Hypercortisolism (HP:0001578)2.11437593
109Hypothermia (HP:0002045)2.10490682
110Hyperacusis (HP:0010780)2.10314484
111Abnormality of calcium-phosphate metabolism (HP:0100530)2.10136537
112Fasciculations (HP:0002380)2.09919260
113Onion bulb formation (HP:0003383)2.06559570
114Distal arthrogryposis (HP:0005684)2.05049627
115Hypolipoproteinemia (HP:0010981)2.05027504
116Glycosuria (HP:0003076)2.03807536
117Abnormality of urine glucose concentration (HP:0011016)2.03807536
118Ileus (HP:0002595)2.02152785
119Thin bony cortex (HP:0002753)2.01898853
120Loss of speech (HP:0002371)2.01344214
121Action tremor (HP:0002345)2.00305217
122Abnormality of purine metabolism (HP:0004352)1.99125214
123Abnormal drinking behavior (HP:0030082)1.98894844
124Polydipsia (HP:0001959)1.98894844
125Ectropion (HP:0000656)1.98406200
126Short nail (HP:0001799)1.98317316
127Palmoplantar keratoderma (HP:0000982)1.96913596
128Hyperparathyroidism (HP:0000843)1.96570911
129Gangrene (HP:0100758)1.96383359
130Nonimmune hydrops fetalis (HP:0001790)1.95908881
131Abnormality of the foot musculature (HP:0001436)1.95485944
132Pruritus (HP:0000989)1.94992554
133Tubulointerstitial fibrosis (HP:0005576)1.94620693
134Truncus arteriosus (HP:0001660)1.94080048
135Rickets (HP:0002748)1.93915783
136Neoplasm of head and neck (HP:0012288)1.93908258
137Esophageal neoplasm (HP:0100751)1.93908258
138Hypoplasia of the uterus (HP:0000013)1.93806142
139Abnormality of the costochondral junction (HP:0000919)1.93676097
140Complement deficiency (HP:0004431)1.92431890
141Abnormality of the salivary glands (HP:0010286)1.92399731
142Lack of skin elasticity (HP:0100679)1.91754318
143Renal tubular acidosis (HP:0001947)1.90710997
144Fat malabsorption (HP:0002630)1.90652344
145Sparse eyelashes (HP:0000653)1.90522808
146Hamartoma of the eye (HP:0010568)1.89647268
147Hyperphosphaturia (HP:0003109)1.89608644
148Hammertoe (HP:0001765)1.88758556
149Cervical subluxation (HP:0003308)1.86767174
150Delayed epiphyseal ossification (HP:0002663)1.86195001
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.86007565
152Osteolytic defects of the hand bones (HP:0009699)1.86007565
153Urinary glycosaminoglycan excretion (HP:0003541)1.86003462
154Mucopolysacchariduria (HP:0008155)1.86003462
155Prolonged neonatal jaundice (HP:0006579)1.85707784
156Akinesia (HP:0002304)1.84731959
157Alopecia of scalp (HP:0002293)1.84663375
158Upper limb amyotrophy (HP:0009129)1.84596260
159Distal upper limb amyotrophy (HP:0007149)1.84596260
160Glioma (HP:0009733)1.82104940
161Bronchomalacia (HP:0002780)1.81550691
162Bone pain (HP:0002653)1.81256892
163Reduced subcutaneous adipose tissue (HP:0003758)1.80984372
164Hypotension (HP:0002615)1.79938688
165Stridor (HP:0010307)1.78830777
166Cerebral aneurysm (HP:0004944)1.78753642
167Cerebral palsy (HP:0100021)1.76442970
168Esophageal varix (HP:0002040)1.76277736
169Hypoalphalipoproteinemia (HP:0003233)1.74501329
170Abnormal tarsal ossification (HP:0008369)1.73851770
171Abnormality of the fingertips (HP:0001211)1.73775942
172Lower limb amyotrophy (HP:0007210)1.73174303
173Nephritis (HP:0000123)1.72581193
174Abnormal glucose tolerance (HP:0001952)1.67788699
175Abnormality of carpal bone ossification (HP:0006257)1.67468690
176Glomerulosclerosis (HP:0000096)1.66097064
177Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64535614
178Abnormality of polysaccharide metabolism (HP:0011012)1.64535614
179Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64535614
180Bulbar palsy (HP:0001283)1.64289473
181Atelectasis (HP:0100750)1.63776872
182Supranuclear gaze palsy (HP:0000605)1.63429071
183Abnormality of alkaline phosphatase activity (HP:0004379)1.62435942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.82315276
2EPHA25.68475228
3MAPKAPK34.91946276
4WNK44.03134908
5MAP3K23.37064753
6MST43.18477426
7NTRK12.99681102
8PBK2.90128700
9MST1R2.84892836
10FER2.74645385
11OXSR12.69320022
12LMTK22.48706472
13TRIB32.46895134
14MAP3K92.36145547
15STK392.35091661
16NME12.32432017
17WNK32.24761546
18MINK12.08242329
19GRK52.08101731
20SIK12.06215046
21LIMK12.03251289
22LATS22.01826371
23PAK41.98866549
24EPHB21.91316049
25SMG11.90389627
26MATK1.89947459
27MAP3K31.81306524
28MAP3K121.69835876
29KSR21.68316579
30WNK11.67289041
31RPS6KB21.51401450
32TESK21.45015958
33EPHA31.44968164
34MAPKAPK51.42865863
35FGFR41.39338611
36MAP3K61.35321444
37NTRK31.27518633
38TRPM71.18253443
39ICK1.15713493
40LRRK21.15552018
41TESK11.13502700
42PIM21.13367205
43MAP2K41.11028168
44MAP2K11.07533779
45GRK71.06944142
46PRKG21.05385868
47LATS10.99030387
48RET0.97545743
49MAP2K20.96156029
50MAP3K10.93934025
51NME20.93074971
52MAP3K110.92431934
53ZAP700.90913393
54PDGFRA0.90054684
55PRPF4B0.88947657
56ADRBK10.85951866
57MET0.84937142
58PKN20.83760994
59PHKG20.82842795
60PHKG10.82842795
61MAP2K60.82785979
62STK380.82108124
63ERN10.81800830
64BCKDK0.80675227
65SGK4940.79744974
66SGK2230.79744974
67PTK20.79284355
68ABL20.78750693
69TAOK10.77771984
70STK38L0.76971789
71RPS6KA20.75395576
72TGFBR20.73747576
73RIPK40.72175780
74CDK70.71603800
75PTK60.70945233
76NEK10.70940033
77PDK40.70884008
78PDK30.70884008
79BCR0.66952022
80FGFR30.65931401
81PIK3CG0.65659807
82MAPK110.65106462
83MAP3K70.64967178
84TNK20.64782692
85PAK30.62017474
86NEK90.59240445
87ILK0.59220530
88FRK0.58908244
89DMPK0.57648875
90MTOR0.57547510
91KDR0.57474283
92EPHB10.55495238
93BUB10.53954107
94ROCK10.53513530
95BRSK10.52451240
96MAPK150.50198888
97PINK10.50086535
98MAP3K80.49828746
99PRKCE0.48948084
100ARAF0.48820596
101GRK10.48794105
102PRKCI0.47696386
103CAMK2B0.47522784
104PDK20.47516177
105BMX0.47274232
106MELK0.46971503
107MYLK0.46728179
108STK240.46411805
109FLT30.44788355
110NTRK20.44681586
111IRAK10.43793506
112CDK80.43166198
113MARK20.41766763
114MAPKAPK20.40886740
115STK100.38946297
116BMPR1B0.38329722
117BLK0.38213426
118EGFR0.36548531
119CDK50.34923867
120PRKD20.34734715
121PRKD10.34599530
122STK110.34502156
123DYRK1B0.34233013
124FGFR20.33414190
125GSK3A0.32919792
126CAMK2D0.32672214
127CAMK2G0.32616335
128PRKACA0.32058503
129CSNK1E0.31593744
130PDGFRB0.30935777
131PRKCZ0.30920853
132TYRO30.30682944
133RIPK10.29299303
134PDPK10.29210988
135EEF2K0.28933944
136MUSK0.27755977
137SGK20.27506708
138PRKACG0.27488704
139PRKCA0.27344291
140CDC42BPA0.27321317
141EIF2AK10.26622783
142ERBB20.26523355
143PRKCG0.26405164
144PAK10.25583506
145TAOK20.22486473
146DAPK30.21532731
147CDK90.21393567
148PRKD30.20263522
149AURKA0.18949474
150DAPK10.18148298
151CHUK0.17939684
152AURKB0.17556608
153HIPK20.17352057

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.45333789
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.10673750
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.94800221
4Galactose metabolism_Homo sapiens_hsa000522.70849869
5Other glycan degradation_Homo sapiens_hsa005112.61937283
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42019121
7Collecting duct acid secretion_Homo sapiens_hsa049662.41508079
8Sphingolipid metabolism_Homo sapiens_hsa006002.19120483
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95376264
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.74546667
11Fatty acid elongation_Homo sapiens_hsa000621.72303308
12Synaptic vesicle cycle_Homo sapiens_hsa047211.70952891
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64302160
14Mineral absorption_Homo sapiens_hsa049781.64046437
15Sulfur relay system_Homo sapiens_hsa041221.63292726
16Proteasome_Homo sapiens_hsa030501.59846313
17Histidine metabolism_Homo sapiens_hsa003401.58740503
18Pentose phosphate pathway_Homo sapiens_hsa000301.57431637
19Protein digestion and absorption_Homo sapiens_hsa049741.56006280
20Phenylalanine metabolism_Homo sapiens_hsa003601.53630618
21Vitamin digestion and absorption_Homo sapiens_hsa049771.52216817
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.47594089
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46254025
24Arachidonic acid metabolism_Homo sapiens_hsa005901.45001841
25Butanoate metabolism_Homo sapiens_hsa006501.41771117
26Bile secretion_Homo sapiens_hsa049761.29759889
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29175004
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28757468
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25976445
30Oxidative phosphorylation_Homo sapiens_hsa001901.17923688
31Pyruvate metabolism_Homo sapiens_hsa006201.17036221
32N-Glycan biosynthesis_Homo sapiens_hsa005101.16806831
33Adherens junction_Homo sapiens_hsa045201.15973299
34Biosynthesis of amino acids_Homo sapiens_hsa012301.15610290
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13881910
36Glutathione metabolism_Homo sapiens_hsa004801.13175938
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10515468
38Propanoate metabolism_Homo sapiens_hsa006401.10300146
39Pancreatic secretion_Homo sapiens_hsa049721.07200106
40Fatty acid degradation_Homo sapiens_hsa000711.05001881
41Linoleic acid metabolism_Homo sapiens_hsa005911.03584739
42Tryptophan metabolism_Homo sapiens_hsa003801.03417213
43Peroxisome_Homo sapiens_hsa041461.00336509
44Fat digestion and absorption_Homo sapiens_hsa049750.99189529
45Gastric acid secretion_Homo sapiens_hsa049710.97760063
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97402070
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97006344
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92714529
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.92417090
50beta-Alanine metabolism_Homo sapiens_hsa004100.90108501
51Glycerolipid metabolism_Homo sapiens_hsa005610.88213702
52Tyrosine metabolism_Homo sapiens_hsa003500.88081222
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86060865
54Renin-angiotensin system_Homo sapiens_hsa046140.85720322
55Vibrio cholerae infection_Homo sapiens_hsa051100.85308168
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85300370
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84543277
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84450373
59Fatty acid metabolism_Homo sapiens_hsa012120.83018098
60Taste transduction_Homo sapiens_hsa047420.82583866
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.78217609
62Thyroid cancer_Homo sapiens_hsa052160.75087187
63Starch and sucrose metabolism_Homo sapiens_hsa005000.75080312
64Dorso-ventral axis formation_Homo sapiens_hsa043200.71782628
65Renin secretion_Homo sapiens_hsa049240.70941807
66ABC transporters_Homo sapiens_hsa020100.70681121
67Insulin resistance_Homo sapiens_hsa049310.70531732
68Parkinsons disease_Homo sapiens_hsa050120.69642493
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69131099
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69008931
71Tight junction_Homo sapiens_hsa045300.68568330
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68326278
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68223808
74Complement and coagulation cascades_Homo sapiens_hsa046100.68198921
75Salivary secretion_Homo sapiens_hsa049700.67839220
76Chemical carcinogenesis_Homo sapiens_hsa052040.66632738
77Ether lipid metabolism_Homo sapiens_hsa005650.65153375
78Cardiac muscle contraction_Homo sapiens_hsa042600.64962791
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64854397
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64541727
81PPAR signaling pathway_Homo sapiens_hsa033200.64436911
82Fatty acid biosynthesis_Homo sapiens_hsa000610.63884616
83Alzheimers disease_Homo sapiens_hsa050100.63022261
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.62566145
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62183184
86Serotonergic synapse_Homo sapiens_hsa047260.62171867
87Steroid biosynthesis_Homo sapiens_hsa001000.61967835
88Folate biosynthesis_Homo sapiens_hsa007900.60389310
89Arginine and proline metabolism_Homo sapiens_hsa003300.59395124
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59289371
91Retinol metabolism_Homo sapiens_hsa008300.58237424
92Pertussis_Homo sapiens_hsa051330.57635063
93VEGF signaling pathway_Homo sapiens_hsa043700.57402908
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57367730
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57145190
96GnRH signaling pathway_Homo sapiens_hsa049120.56860885
97Sulfur metabolism_Homo sapiens_hsa009200.56383628
98Focal adhesion_Homo sapiens_hsa045100.56286789
99Thyroid hormone synthesis_Homo sapiens_hsa049180.54139677
100Notch signaling pathway_Homo sapiens_hsa043300.53023039
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52664960
102Olfactory transduction_Homo sapiens_hsa047400.51647796
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.51573119
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.50536882
105Phagosome_Homo sapiens_hsa041450.49818316
106Pancreatic cancer_Homo sapiens_hsa052120.49334695
107Hedgehog signaling pathway_Homo sapiens_hsa043400.48762535
108Arginine biosynthesis_Homo sapiens_hsa002200.48319090
109Ovarian steroidogenesis_Homo sapiens_hsa049130.45372605
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44970648
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44270286
112Bladder cancer_Homo sapiens_hsa052190.42927036
113Hepatitis C_Homo sapiens_hsa051600.42811417
114Metabolic pathways_Homo sapiens_hsa011000.42767638
115Inositol phosphate metabolism_Homo sapiens_hsa005620.42220848
116Axon guidance_Homo sapiens_hsa043600.41028277
117ECM-receptor interaction_Homo sapiens_hsa045120.40856502
118Melanogenesis_Homo sapiens_hsa049160.40477829
119Lysosome_Homo sapiens_hsa041420.39012497
120Insulin secretion_Homo sapiens_hsa049110.38794587
121Endocytosis_Homo sapiens_hsa041440.37219875
122Choline metabolism in cancer_Homo sapiens_hsa052310.36913135
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35994905
124Insulin signaling pathway_Homo sapiens_hsa049100.35892822
125Carbon metabolism_Homo sapiens_hsa012000.35718204
126Fructose and mannose metabolism_Homo sapiens_hsa000510.35461308
127Melanoma_Homo sapiens_hsa052180.34132354
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.33745570
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31233892
130ErbB signaling pathway_Homo sapiens_hsa040120.31006222
131Proteoglycans in cancer_Homo sapiens_hsa052050.30371529
132Endometrial cancer_Homo sapiens_hsa052130.27827491
133Vitamin B6 metabolism_Homo sapiens_hsa007500.24291070
134Renal cell carcinoma_Homo sapiens_hsa052110.23923572
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23696230
136Glucagon signaling pathway_Homo sapiens_hsa049220.22974917
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22414734
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21652183
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21158131

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