SUSD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.31044498
2locomotory exploration behavior (GO:0035641)5.56016573
3vocalization behavior (GO:0071625)5.48085509
4synaptic vesicle maturation (GO:0016188)5.45130615
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43221841
6synaptic vesicle exocytosis (GO:0016079)5.43000007
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37279170
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30950411
9glutamate secretion (GO:0014047)5.22688642
10regulation of glutamate receptor signaling pathway (GO:1900449)5.03820153
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.91040291
12regulation of synaptic vesicle exocytosis (GO:2000300)4.89475226
13protein localization to synapse (GO:0035418)4.82831113
14neuron cell-cell adhesion (GO:0007158)4.65570488
15neurotransmitter secretion (GO:0007269)4.59303465
16neuronal action potential propagation (GO:0019227)4.50481727
17exploration behavior (GO:0035640)4.48536538
18regulation of synaptic vesicle transport (GO:1902803)4.46768751
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.43852270
20regulation of neuronal synaptic plasticity (GO:0048168)4.40955798
21glutamate receptor signaling pathway (GO:0007215)4.37982355
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.35749835
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34976251
24synaptic transmission, glutamatergic (GO:0035249)4.33348333
25neurotransmitter-gated ion channel clustering (GO:0072578)4.17956084
26neuron-neuron synaptic transmission (GO:0007270)4.11071824
27gamma-aminobutyric acid transport (GO:0015812)4.05577201
28layer formation in cerebral cortex (GO:0021819)3.99384827
29synaptic vesicle endocytosis (GO:0048488)3.94574394
30long-term memory (GO:0007616)3.85879209
31dendritic spine morphogenesis (GO:0060997)3.85632513
32regulation of synapse structural plasticity (GO:0051823)3.83629991
33positive regulation of synapse maturation (GO:0090129)3.82501647
34chemosensory behavior (GO:0007635)3.81363892
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79132256
36neurotransmitter transport (GO:0006836)3.75658211
37detection of calcium ion (GO:0005513)3.75465875
38neuron recognition (GO:0008038)3.73608795
39neuromuscular process controlling posture (GO:0050884)3.67965461
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67114144
41cellular potassium ion homeostasis (GO:0030007)3.65419622
42regulation of postsynaptic membrane potential (GO:0060078)3.64857745
43proline transport (GO:0015824)3.63840722
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.61898549
45positive regulation of membrane potential (GO:0045838)3.61444239
46cerebellar Purkinje cell layer development (GO:0021680)3.60140644
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54348698
48regulation of synaptic plasticity (GO:0048167)3.54330004
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54153256
50long-term synaptic potentiation (GO:0060291)3.54090106
51transmission of nerve impulse (GO:0019226)3.52533646
52positive regulation of neurotransmitter transport (GO:0051590)3.51446756
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.49984045
54regulation of neurotransmitter levels (GO:0001505)3.49726193
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48217487
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46020868
57regulation of dendritic spine morphogenesis (GO:0061001)3.42135884
58cerebellar Purkinje cell differentiation (GO:0021702)3.41107253
59potassium ion homeostasis (GO:0055075)3.40991313
60behavioral defense response (GO:0002209)3.38378047
61behavioral fear response (GO:0001662)3.38378047
62positive regulation of neurotransmitter secretion (GO:0001956)3.37563445
63regulation of neurotransmitter secretion (GO:0046928)3.32573168
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28803659
65axonal fasciculation (GO:0007413)3.28416231
66activation of protein kinase A activity (GO:0034199)3.28052305
67dendritic spine organization (GO:0097061)3.27653233
68sodium ion export (GO:0071436)3.27514415
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27168927
70neuromuscular process controlling balance (GO:0050885)3.26361417
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25081493
72righting reflex (GO:0060013)3.22146874
73regulation of vesicle fusion (GO:0031338)3.16789882
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16359682
75fear response (GO:0042596)3.15016791
76membrane hyperpolarization (GO:0060081)3.13683372
77negative regulation of dendrite morphogenesis (GO:0050774)3.13257583
78dendrite morphogenesis (GO:0048813)3.11197827
79membrane depolarization (GO:0051899)3.11099296
80mating behavior (GO:0007617)3.10222562
81innervation (GO:0060384)3.10056322
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09522758
83regulation of glutamate secretion (GO:0014048)3.09401821
84postsynaptic membrane organization (GO:0001941)3.07875813
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07338328
86learning (GO:0007612)3.06293156
87presynaptic membrane organization (GO:0097090)3.05492040
88cell communication by electrical coupling (GO:0010644)3.04920671
89regulation of neurotransmitter transport (GO:0051588)3.04382541
90membrane depolarization during action potential (GO:0086010)3.02770726
91positive regulation of synaptic transmission (GO:0050806)3.02433384
92regulation of synaptic transmission (GO:0050804)3.02406322
93synaptic transmission (GO:0007268)3.01922815
94prepulse inhibition (GO:0060134)3.01095156
95cellular sodium ion homeostasis (GO:0006883)3.00961417
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.00869029
97cell communication involved in cardiac conduction (GO:0086065)3.00622329
98regulation of synapse maturation (GO:0090128)2.99600352
99behavioral response to cocaine (GO:0048148)2.99583678
100synapse assembly (GO:0007416)2.99464583
101positive regulation of dendritic spine development (GO:0060999)2.98807288
102neuromuscular process (GO:0050905)2.96051398
103response to histamine (GO:0034776)2.95793073
104cerebellar granule cell differentiation (GO:0021707)2.95282733
105regulation of ARF protein signal transduction (GO:0032012)2.94852603
106presynaptic membrane assembly (GO:0097105)2.94381581
107neuronal ion channel clustering (GO:0045161)2.94302362
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94223227
109neurofilament cytoskeleton organization (GO:0060052)2.93955017
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93729617
111social behavior (GO:0035176)2.92541153
112intraspecies interaction between organisms (GO:0051703)2.92541153
113response to auditory stimulus (GO:0010996)2.89711782
114signal release (GO:0023061)2.87887913
115startle response (GO:0001964)2.86935749
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.86110582
117regulation of dendritic spine development (GO:0060998)2.85663295
118auditory behavior (GO:0031223)2.84992910
119urinary tract smooth muscle contraction (GO:0014848)2.84298696
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75951709
121negative regulation of dendrite development (GO:2000171)2.75160133
122serotonin metabolic process (GO:0042428)2.73930899
123long term synaptic depression (GO:0060292)2.72392370
124regulation of voltage-gated calcium channel activity (GO:1901385)2.71391056
125calcium ion-dependent exocytosis (GO:0017156)2.69317592
126establishment of synaptic vesicle localization (GO:0097480)2.68366376
127synaptic vesicle transport (GO:0048489)2.68366376
128insulin secretion (GO:0030073)2.61395236
129potassium ion import (GO:0010107)2.58443758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16336181
2GBX2_23144817_ChIP-Seq_PC3_Human3.54018500
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13449170
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10450772
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07209411
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78006156
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71520734
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71520734
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71470875
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63533713
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57033298
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53794102
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51336948
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.49409584
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45578571
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.45056550
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.34936842
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.32209829
19* DROSHA_22980978_ChIP-Seq_HELA_Human2.29568161
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28080766
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26729508
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22601508
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18267412
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17350095
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.13029966
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11582988
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99261215
28TAF15_26573619_Chip-Seq_HEK293_Human1.96007527
29AR_21572438_ChIP-Seq_LNCaP_Human1.92933950
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88261835
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85363613
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81930889
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78596770
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76771618
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.59282220
36* ERG_21242973_ChIP-ChIP_JURKAT_Human1.59036446
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57657062
38ZNF274_21170338_ChIP-Seq_K562_Hela1.48204531
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47310133
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46737127
41P300_19829295_ChIP-Seq_ESCs_Human1.42565903
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41777321
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39917017
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33794454
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.32664790
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30731749
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.30695321
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29359620
49AR_25329375_ChIP-Seq_VCAP_Human1.28010107
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27828466
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26606026
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26213510
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24781544
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.23612985
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20638480
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20482038
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19038913
58AR_19668381_ChIP-Seq_PC3_Human1.18878922
59STAT3_23295773_ChIP-Seq_U87_Human1.17585731
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17143709
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.15070684
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14333409
63RNF2_27304074_Chip-Seq_NSC_Mouse1.14048664
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13596990
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.12730018
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12562059
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12349402
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.11507027
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.11307774
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11190121
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.09777343
72IGF1R_20145208_ChIP-Seq_DFB_Human1.08705790
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06501512
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05532875
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02746678
76TCF4_23295773_ChIP-Seq_U87_Human1.02524664
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02465210
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.02049088
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99479853
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98191389
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97977652
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97710338
83RUNX2_22187159_ChIP-Seq_PCA_Human0.97499739
84AHR_22903824_ChIP-Seq_MCF-7_Human0.97299685
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96081166
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94879791
87* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94669820
88HTT_18923047_ChIP-ChIP_STHdh_Human0.94515961
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94167882
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93966952
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92866795
92* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92520950
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92373312
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91882034
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.91184633
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90893418
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90893418
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.90553113
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.90129900
100KDM2B_26808549_Chip-Seq_K562_Human0.89793875
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89403301
102* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89103856
103FUS_26573619_Chip-Seq_HEK293_Human0.88504482
104JUN_21703547_ChIP-Seq_K562_Human0.87857048
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.86834362
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86440999
107ER_23166858_ChIP-Seq_MCF-7_Human0.85566144
108* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84914261
109CTCF_27219007_Chip-Seq_Bcells_Human0.84652583
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.84109561
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83175119
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82844865
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81158422
114* P53_22387025_ChIP-Seq_ESCs_Mouse0.80764971
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.79754404
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79579225
117CBP_20019798_ChIP-Seq_JUKART_Human0.77064755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.34153034
2MP0003880_abnormal_central_pattern4.95250618
3MP0003635_abnormal_synaptic_transmissio4.16912453
4MP0009745_abnormal_behavioral_response3.48337773
5MP0004270_analgesia3.37755927
6MP0002063_abnormal_learning/memory/cond3.37245782
7MP0002064_seizures3.25250280
8MP0001968_abnormal_touch/_nociception3.17135657
9MP0009046_muscle_twitch3.07798109
10MP0002572_abnormal_emotion/affect_behav2.85093933
11MP0002272_abnormal_nervous_system2.66965779
12MP0005423_abnormal_somatic_nervous2.62317461
13MP0002822_catalepsy2.61424114
14MP0002736_abnormal_nociception_after2.53288820
15MP0001486_abnormal_startle_reflex2.52542043
16MP0002734_abnormal_mechanical_nocicepti2.50000241
17MP0001501_abnormal_sleep_pattern2.41346502
18MP0002735_abnormal_chemical_nociception2.37184692
19MP0001440_abnormal_grooming_behavior2.32853514
20MP0006276_abnormal_autonomic_nervous2.12232565
21MP0002067_abnormal_sensory_capabilities2.02996043
22MP0002733_abnormal_thermal_nociception2.01505510
23MP0003329_amyloid_beta_deposits2.00362408
24MP0002184_abnormal_innervation1.92436122
25MP0001970_abnormal_pain_threshold1.90289669
26MP0002557_abnormal_social/conspecific_i1.78710138
27MP0000778_abnormal_nervous_system1.78404346
28MP0004858_abnormal_nervous_system1.76137564
29MP0005386_behavior/neurological_phenoty1.72050632
30MP0004924_abnormal_behavior1.72050632
31MP0010234_abnormal_vibrissa_follicle1.72009061
32MP0001984_abnormal_olfaction1.69180472
33MP0008569_lethality_at_weaning1.67693837
34MP0008877_abnormal_DNA_methylation1.67163590
35MP0004811_abnormal_neuron_physiology1.66288062
36MP0009780_abnormal_chondrocyte_physiolo1.57241203
37MP0003879_abnormal_hair_cell1.56548409
38MP0000955_abnormal_spinal_cord1.54064002
39MP0005646_abnormal_pituitary_gland1.53988908
40MP0003122_maternal_imprinting1.52674257
41MP0002909_abnormal_adrenal_gland1.51669497
42MP0001529_abnormal_vocalization1.46613744
43MP0004142_abnormal_muscle_tone1.45703900
44MP0002066_abnormal_motor_capabilities/c1.42659539
45MP0002882_abnormal_neuron_morphology1.41733934
46MP0003195_calcinosis1.38504805
47MP0005645_abnormal_hypothalamus_physiol1.36107003
48MP0001502_abnormal_circadian_rhythm1.34041095
49MP0004885_abnormal_endolymph1.33361889
50MP0003787_abnormal_imprinting1.24463490
51MP0001905_abnormal_dopamine_level1.24432520
52MP0003633_abnormal_nervous_system1.20763127
53MP0004043_abnormal_pH_regulation1.17246061
54MP0005551_abnormal_eye_electrophysiolog1.12256492
55MP0002152_abnormal_brain_morphology1.07163239
56MP0003631_nervous_system_phenotype1.06323592
57MP0001944_abnormal_pancreas_morphology1.05182759
58MP0002229_neurodegeneration1.03187457
59MP0008872_abnormal_physiological_respon1.03108869
60MP0002069_abnormal_eating/drinking_beha1.01672526
61MP0008874_decreased_physiological_sensi0.94929409
62MP0000604_amyloidosis0.94319606
63MP0004742_abnormal_vestibular_system0.92367120
64MP0010386_abnormal_urinary_bladder0.91776491
65MP0005535_abnormal_body_temperature0.91000868
66MP0002876_abnormal_thyroid_physiology0.90686594
67MP0001188_hyperpigmentation0.89807075
68MP0004145_abnormal_muscle_electrophysio0.89114593
69MP0001177_atelectasis0.88570435
70MP0002837_dystrophic_cardiac_calcinosis0.88449905
71MP0002693_abnormal_pancreas_physiology0.87642419
72MP0008875_abnormal_xenobiotic_pharmacok0.86364220
73MP0000751_myopathy0.85984755
74MP0001963_abnormal_hearing_physiology0.84966290
75MP0002752_abnormal_somatic_nervous0.83297029
76MP0002090_abnormal_vision0.82860032
77MP0003632_abnormal_nervous_system0.82273700
78MP0008961_abnormal_basal_metabolism0.81741114
79MP0004085_abnormal_heartbeat0.80239524
80MP0005394_taste/olfaction_phenotype0.79615105
81MP0005499_abnormal_olfactory_system0.79615105
82MP0003690_abnormal_glial_cell0.79352476
83MP0003634_abnormal_glial_cell0.78636879
84MP0002653_abnormal_ependyma_morphology0.78317326
85MP0004510_myositis0.77580561
86MP0003011_delayed_dark_adaptation0.77458620
87MP0000631_abnormal_neuroendocrine_gland0.75770370
88MP0005379_endocrine/exocrine_gland_phen0.75357669
89MP0001765_abnormal_ion_homeostasis0.75074593
90MP0002078_abnormal_glucose_homeostasis0.75042996
91MP0000566_synostosis0.74851562
92MP0000427_abnormal_hair_cycle0.72948330
93MP0002102_abnormal_ear_morphology0.68434141
94MP0003075_altered_response_to0.67840053
95MP0001986_abnormal_taste_sensitivity0.67296990
96MP0000920_abnormal_myelination0.67113514
97MP0003953_abnormal_hormone_level0.66887292
98MP0000013_abnormal_adipose_tissue0.66845881
99MP0005448_abnormal_energy_balance0.64400228
100MP0001756_abnormal_urination0.63686244
101MP0001485_abnormal_pinna_reflex0.62394149
102MP0003123_paternal_imprinting0.60880487
103MP0000639_abnormal_adrenal_gland0.60332402
104MP0010329_abnormal_lipoprotein_level0.59594347
105MP0005253_abnormal_eye_physiology0.59469990
106MP0005085_abnormal_gallbladder_physiolo0.59406940
107MP0002928_abnormal_bile_duct0.58395767
108MP0003868_abnormal_feces_composition0.57899367
109MP0003137_abnormal_impulse_conducting0.57779370
110MP0010678_abnormal_skin_adnexa0.56984759
111MP0001664_abnormal_digestion0.56626975
112MP0002638_abnormal_pupillary_reflex0.55644495
113MP0003861_abnormal_nervous_system0.53111558
114MP0003283_abnormal_digestive_organ0.52681357
115MP0002082_postnatal_lethality0.52586859
116MP0010770_preweaning_lethality0.52586859
117MP0010769_abnormal_survival0.52567613
118MP0004215_abnormal_myocardial_fiber0.52499089
119MP0001943_abnormal_respiration0.52219867
120MP0003956_abnormal_body_size0.51650983
121MP0004233_abnormal_muscle_weight0.51586240
122MP0006072_abnormal_retinal_apoptosis0.49958581
123MP0010768_mortality/aging0.49312624
124MP0000026_abnormal_inner_ear0.49179505
125MP0005623_abnormal_meninges_morphology0.48301294
126MP0003121_genomic_imprinting0.48005155

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.30715619
2Myokymia (HP:0002411)7.02844177
3Focal seizures (HP:0007359)5.94599705
4Visual hallucinations (HP:0002367)5.79868564
5Atonic seizures (HP:0010819)4.84721180
6Epileptic encephalopathy (HP:0200134)4.77626740
7Absence seizures (HP:0002121)4.71583995
8Febrile seizures (HP:0002373)4.70403110
9Progressive cerebellar ataxia (HP:0002073)4.30856550
10Dialeptic seizures (HP:0011146)4.22890753
11Generalized tonic-clonic seizures (HP:0002069)4.07112752
12Hypoglycemic seizures (HP:0002173)3.75026485
13Supranuclear gaze palsy (HP:0000605)3.72753324
14Action tremor (HP:0002345)3.71884633
15Hypoglycemic coma (HP:0001325)3.50342001
16Hyperventilation (HP:0002883)3.47713132
17Impaired vibration sensation in the lower limbs (HP:0002166)3.40056188
18Poor eye contact (HP:0000817)3.33719483
19Hyperinsulinemic hypoglycemia (HP:0000825)3.29537831
20Broad-based gait (HP:0002136)3.27850708
21Dysdiadochokinesis (HP:0002075)3.25136136
22Abnormality of the lower motor neuron (HP:0002366)3.17865783
23Increased circulating renin level (HP:0000848)3.14480206
24Impaired social interactions (HP:0000735)3.13920833
25Abnormal social behavior (HP:0012433)3.13920833
26Gaze-evoked nystagmus (HP:0000640)3.10221935
27Abnormal eating behavior (HP:0100738)3.09097975
28Depression (HP:0000716)3.07180055
29Ankle clonus (HP:0011448)3.06265985
30Dysmetria (HP:0001310)3.02713103
31Postural instability (HP:0002172)2.96069502
32Anxiety (HP:0000739)2.95974770
33Amblyopia (HP:0000646)2.95453686
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.89736704
35Urinary bladder sphincter dysfunction (HP:0002839)2.83389773
36Status epilepticus (HP:0002133)2.82689923
37Excessive salivation (HP:0003781)2.80194539
38Drooling (HP:0002307)2.80194539
39Truncal ataxia (HP:0002078)2.75210972
40Mutism (HP:0002300)2.71861836
41Cerebral inclusion bodies (HP:0100314)2.67193705
42Ketoacidosis (HP:0001993)2.66883001
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.65996141
44Spastic gait (HP:0002064)2.63848445
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.61941329
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61941329
47Torticollis (HP:0000473)2.60965455
48Neurofibrillary tangles (HP:0002185)2.60853958
49Epileptiform EEG discharges (HP:0011182)2.58190107
50Scanning speech (HP:0002168)2.58034680
51Progressive inability to walk (HP:0002505)2.55128932
52Polyphagia (HP:0002591)2.50913009
53Focal dystonia (HP:0004373)2.50223908
54Genetic anticipation (HP:0003743)2.49672991
55Sleep apnea (HP:0010535)2.49615148
56EEG with generalized epileptiform discharges (HP:0011198)2.49270991
57Hemiparesis (HP:0001269)2.48223994
58Akinesia (HP:0002304)2.47756299
59Urinary urgency (HP:0000012)2.46964473
60Intention tremor (HP:0002080)2.45361653
61Hyperglycemia (HP:0003074)2.44045560
62Hypothermia (HP:0002045)2.41975745
63Impaired smooth pursuit (HP:0007772)2.41513308
64Bradykinesia (HP:0002067)2.41054346
65Absent speech (HP:0001344)2.38531428
66Generalized myoclonic seizures (HP:0002123)2.37931917
67Insulin-resistant diabetes mellitus (HP:0000831)2.37600367
68Hemiplegia (HP:0002301)2.35805630
69Hypsarrhythmia (HP:0002521)2.33005898
70Impaired vibratory sensation (HP:0002495)2.27958193
71Abnormal respiratory motile cilium morphology (HP:0005938)2.26839567
72Abnormal respiratory epithelium morphology (HP:0012253)2.26839567
73Craniofacial dystonia (HP:0012179)2.26254705
74Gait imbalance (HP:0002141)2.24269796
75Abnormality of the corticospinal tract (HP:0002492)2.19160039
76Large for gestational age (HP:0001520)2.16638155
77Blue irides (HP:0000635)2.16504643
78Abnormal respiratory motile cilium physiology (HP:0012261)2.16224561
79Papilledema (HP:0001085)2.14603489
80Delusions (HP:0000746)2.13785489
81Rhinitis (HP:0012384)2.13481507
82Inability to walk (HP:0002540)2.12933707
83Abnormality of ocular smooth pursuit (HP:0000617)2.11978879
84Diplopia (HP:0000651)2.11325356
85Abnormality of binocular vision (HP:0011514)2.11325356
86Ventricular fibrillation (HP:0001663)2.10614254
87Symptomatic seizures (HP:0011145)2.10032616
88Stereotypic behavior (HP:0000733)2.09754474
89Abnormal ciliary motility (HP:0012262)2.08752092
90Diminished movement (HP:0002374)2.08310280
91Termporal pattern (HP:0011008)2.06986829
92Insidious onset (HP:0003587)2.06986829
93Muscular hypotonia of the trunk (HP:0008936)2.06780770
94Late onset (HP:0003584)2.06432461
95Lower limb muscle weakness (HP:0007340)2.05479950
96Psychosis (HP:0000709)2.05133301
97Postural tremor (HP:0002174)2.04849496
98Pheochromocytoma (HP:0002666)2.01124901
99Gait ataxia (HP:0002066)2.01115786
100Fetal akinesia sequence (HP:0001989)2.01026508
101Failure to thrive in infancy (HP:0001531)2.00405437
102Agitation (HP:0000713)1.99985933
103Peripheral hypomyelination (HP:0007182)1.98294303
104Dysmetric saccades (HP:0000641)1.96043947
105Abnormality of the pancreatic islet cells (HP:0006476)1.91964058
106Abnormality of endocrine pancreas physiology (HP:0012093)1.91964058
107Obstructive sleep apnea (HP:0002870)1.91841751
108Abnormality of saccadic eye movements (HP:0000570)1.90997558
109Hyperphosphatemia (HP:0002905)1.89526571
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.89335510
111Hypomagnesemia (HP:0002917)1.88764428
112Cerebral hypomyelination (HP:0006808)1.88312067
113Limb dystonia (HP:0002451)1.87992183
114Hypoventilation (HP:0002791)1.87688182
115Medial flaring of the eyebrow (HP:0010747)1.87657106
116Hypokinesia (HP:0002375)1.87513214
117Incomplete penetrance (HP:0003829)1.87484755
118Poor suck (HP:0002033)1.86965093
119Megalencephaly (HP:0001355)1.84688174
120Annular pancreas (HP:0001734)1.84408354
121Neuronal loss in central nervous system (HP:0002529)1.83588216
122Congenital malformation of the right heart (HP:0011723)1.83189679
123Double outlet right ventricle (HP:0001719)1.83189679
124Specific learning disability (HP:0001328)1.82970228
125Sensorimotor neuropathy (HP:0007141)1.82587341
126Syncope (HP:0001279)1.82265863
127Clonus (HP:0002169)1.81626341
128Enlarged penis (HP:0000040)1.81084960
129Abnormality of salivation (HP:0100755)1.79776897
130Retinal dysplasia (HP:0007973)1.79465397
131Insomnia (HP:0100785)1.79423438
132Rapidly progressive (HP:0003678)1.77965196
133Type II lissencephaly (HP:0007260)1.76386290
134Hypoplasia of the brainstem (HP:0002365)1.74960783
135Aplasia/Hypoplasia of the brainstem (HP:0007362)1.74960783
136Rigidity (HP:0002063)1.74832614
137Amyotrophic lateral sclerosis (HP:0007354)1.73913215
138Neuroendocrine neoplasm (HP:0100634)1.73392621
139Spastic tetraplegia (HP:0002510)1.72446252
140Morphological abnormality of the pyramidal tract (HP:0002062)1.72332942
141Esotropia (HP:0000565)1.72086540
142Anosmia (HP:0000458)1.71863993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67106589
2EPHA44.18132406
3MAP3K94.02438511
4MAP3K42.98819429
5MINK12.84668884
6MARK12.72716646
7MAP2K72.45722634
8DAPK22.44258708
9MAP3K122.37527420
10FRK2.36906289
11KSR22.23500983
12PAK62.23084442
13MAP2K42.20739313
14NTRK22.16383002
15CASK1.99543122
16KSR11.87916976
17MAP4K21.84608895
18TESK11.82160910
19ARAF1.75753153
20FGFR21.72975482
21PRKD31.69016954
22TNIK1.62982232
23NTRK11.62580913
24DAPK11.58932658
25RIPK41.56595301
26FES1.52849855
27PNCK1.50831063
28GRK51.48586624
29CDK51.47954534
30CAMKK11.47805926
31TYRO31.45827853
32PRPF4B1.41264290
33PLK21.38754422
34MAP3K131.36978145
35SIK21.34068179
36MAPK131.29876546
37PRKCG1.29786284
38UHMK11.27720457
39STK381.27647866
40CDK191.14698606
41LATS21.08184153
42MAP3K21.06080157
43CAMK2A1.04019837
44SIK30.99404469
45CSNK1G30.98609216
46PHKG10.97629141
47PHKG20.97629141
48CDK180.91340848
49MAPK150.88767431
50SGK2230.87416487
51SGK4940.87416487
52CAMK10.86710907
53CDK140.86587150
54CDK150.86052953
55TAOK10.85976592
56LIMK10.85938260
57CSNK1G10.84812445
58CAMK2B0.83786453
59MAP2K60.82433298
60RAF10.82108865
61PAK30.81956739
62PTK2B0.80046193
63DYRK1A0.78649335
64PINK10.78331126
65RET0.77080824
66STK110.74697054
67CDK11A0.74188162
68ERBB30.72601783
69CAMKK20.72037585
70PRKAA10.71463011
71CSNK1A1L0.70916273
72LMTK20.70290622
73FER0.69863483
74PRKCH0.68887864
75SGK20.67563310
76TNK20.67101518
77OXSR10.66936696
78NME10.64508879
79MAP3K10.63652419
80BMPR20.60617394
81HIPK20.60413427
82SGK10.59602243
83PRKCZ0.58349684
84FGR0.57504547
85MARK20.57424345
86CAMK2G0.56914724
87BRAF0.54966702
88CSNK1G20.54898102
89CAMK2D0.54888592
90BCR0.54481833
91AKT30.53220717
92DMPK0.52903312
93INSRR0.52283176
94CSNK1D0.52000035
95PRKCE0.51337881
96SGK30.51192066
97MAP3K60.50714850
98MAP2K10.49439914
99RPS6KA30.48051006
100FGFR30.48030008
101PDPK10.47163423
102PDK10.47068156
103TRIM280.46377876
104CAMK1G0.44763394
105CSNK1A10.44028430
106MAPK120.43538058
107MAPK100.42367254
108ALK0.42339194
109MAP3K70.41504963
110CAMK40.41164534
111PRKCI0.38769852
112FYN0.38577545
113NEK10.38407927
114PRKG10.37740338
115CAMK1D0.36417559
116PKN10.36342062
117DYRK20.36180776
118SCYL20.35888325
119CDC42BPA0.35552710
120PRKCB0.32211461
121WNK30.31973244
122PRKACA0.31502723
123PRKCA0.30846402
124NEK60.29834865
125RPS6KA20.29079281
126CSNK1E0.28623000

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.06500568
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48572839
3GABAergic synapse_Homo sapiens_hsa047272.86021852
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.76574546
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75583932
6Olfactory transduction_Homo sapiens_hsa047402.65714084
7Glutamatergic synapse_Homo sapiens_hsa047242.59738607
8Circadian entrainment_Homo sapiens_hsa047132.58068776
9Long-term potentiation_Homo sapiens_hsa047202.53509177
10Morphine addiction_Homo sapiens_hsa050322.47882368
11Amphetamine addiction_Homo sapiens_hsa050312.30647508
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14427873
13Dopaminergic synapse_Homo sapiens_hsa047282.05124785
14Salivary secretion_Homo sapiens_hsa049702.03999184
15Insulin secretion_Homo sapiens_hsa049111.93307575
16Taste transduction_Homo sapiens_hsa047421.86607307
17Cholinergic synapse_Homo sapiens_hsa047251.80490129
18Gastric acid secretion_Homo sapiens_hsa049711.71495663
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68733866
20Long-term depression_Homo sapiens_hsa047301.64952124
21Collecting duct acid secretion_Homo sapiens_hsa049661.64835034
22Serotonergic synapse_Homo sapiens_hsa047261.62035139
23Oxytocin signaling pathway_Homo sapiens_hsa049211.50516133
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50425329
25Cocaine addiction_Homo sapiens_hsa050301.50025876
26Calcium signaling pathway_Homo sapiens_hsa040201.49434741
27Nitrogen metabolism_Homo sapiens_hsa009101.49046203
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48811298
29Renin secretion_Homo sapiens_hsa049241.48767948
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43661994
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41881315
32GnRH signaling pathway_Homo sapiens_hsa049121.35245669
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30546092
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27566246
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24789517
36Gap junction_Homo sapiens_hsa045401.22823813
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19824595
38cAMP signaling pathway_Homo sapiens_hsa040241.14198160
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10905185
40Axon guidance_Homo sapiens_hsa043601.05995901
41Cardiac muscle contraction_Homo sapiens_hsa042601.05477259
42Vitamin B6 metabolism_Homo sapiens_hsa007501.03724740
43Regulation of autophagy_Homo sapiens_hsa041401.02414936
44Type II diabetes mellitus_Homo sapiens_hsa049301.01258403
45Estrogen signaling pathway_Homo sapiens_hsa049150.98704073
46Arginine biosynthesis_Homo sapiens_hsa002200.97318382
47Vibrio cholerae infection_Homo sapiens_hsa051100.96245303
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94580160
49Melanogenesis_Homo sapiens_hsa049160.93878257
50Glioma_Homo sapiens_hsa052140.93274063
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92730953
52Bile secretion_Homo sapiens_hsa049760.89255899
53ErbB signaling pathway_Homo sapiens_hsa040120.86529197
54Protein export_Homo sapiens_hsa030600.83435947
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82939542
56Prion diseases_Homo sapiens_hsa050200.80688930
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.78988633
58Butanoate metabolism_Homo sapiens_hsa006500.77570817
59Phototransduction_Homo sapiens_hsa047440.76934447
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.75956746
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73891227
62Oocyte meiosis_Homo sapiens_hsa041140.73125472
63Sphingolipid metabolism_Homo sapiens_hsa006000.72599090
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71390435
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71105096
66Phenylalanine metabolism_Homo sapiens_hsa003600.70711495
67Thyroid hormone synthesis_Homo sapiens_hsa049180.70024184
68Dorso-ventral axis formation_Homo sapiens_hsa043200.69241294
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.67933062
70Pancreatic secretion_Homo sapiens_hsa049720.67606785
71Fatty acid elongation_Homo sapiens_hsa000620.64704443
72Choline metabolism in cancer_Homo sapiens_hsa052310.62755038
73beta-Alanine metabolism_Homo sapiens_hsa004100.59536510
74Glucagon signaling pathway_Homo sapiens_hsa049220.58871415
75Histidine metabolism_Homo sapiens_hsa003400.56802633
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54582549
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53320491
78Alzheimers disease_Homo sapiens_hsa050100.52361328
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51856250
80MAPK signaling pathway_Homo sapiens_hsa040100.51673868
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50886706
82AMPK signaling pathway_Homo sapiens_hsa041520.50838093
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49578797
84Oxidative phosphorylation_Homo sapiens_hsa001900.48761440
85Dilated cardiomyopathy_Homo sapiens_hsa054140.47606014
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46991714
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45998402
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44454356
89ABC transporters_Homo sapiens_hsa020100.44096985
90VEGF signaling pathway_Homo sapiens_hsa043700.42038363
91Ras signaling pathway_Homo sapiens_hsa040140.41611854
92Tight junction_Homo sapiens_hsa045300.40821715
93Type I diabetes mellitus_Homo sapiens_hsa049400.40479707
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.37902297
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37015563
96Rap1 signaling pathway_Homo sapiens_hsa040150.36924220
97Inositol phosphate metabolism_Homo sapiens_hsa005620.35910754
98Circadian rhythm_Homo sapiens_hsa047100.34206079
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34088823
100Ovarian steroidogenesis_Homo sapiens_hsa049130.32688300
101Peroxisome_Homo sapiens_hsa041460.32595218
102Alcoholism_Homo sapiens_hsa050340.31977311
103Insulin signaling pathway_Homo sapiens_hsa049100.31047215
104mTOR signaling pathway_Homo sapiens_hsa041500.30467190
105Huntingtons disease_Homo sapiens_hsa050160.30367655
106Arginine and proline metabolism_Homo sapiens_hsa003300.30356302
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.30156601
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.29710588
109Parkinsons disease_Homo sapiens_hsa050120.29704674
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27915672
111Fatty acid biosynthesis_Homo sapiens_hsa000610.27605759
112Endometrial cancer_Homo sapiens_hsa052130.27290165
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26913755
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26564629
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25738112
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25575326
117Wnt signaling pathway_Homo sapiens_hsa043100.24951040
118Endocytosis_Homo sapiens_hsa041440.24614343
119Non-small cell lung cancer_Homo sapiens_hsa052230.24454368
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24142640

Most similar genes based on co-expression Upload to Enrichr

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