SUSD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67826989
2negative regulation of cell killing (GO:0031342)4.67826989
3response to peptidoglycan (GO:0032494)4.14687241
4neutrophil activation involved in immune response (GO:0002283)3.85214347
5immunoglobulin mediated immune response (GO:0016064)3.70542578
6detection of other organism (GO:0098543)3.67000755
7regulation of B cell receptor signaling pathway (GO:0050855)3.58636066
8cellular extravasation (GO:0045123)3.52500771
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47785895
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.47785895
11modulation by symbiont of host immune response (GO:0052553)3.47785895
12positive regulation by symbiont of host defense response (GO:0052509)3.47785895
13modulation by symbiont of host defense response (GO:0052031)3.47785895
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47785895
15detection of bacterium (GO:0016045)3.47057925
16cellular response to type I interferon (GO:0071357)3.46081427
17type I interferon signaling pathway (GO:0060337)3.46081427
18response to type I interferon (GO:0034340)3.43338116
19germinal center formation (GO:0002467)3.39832162
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.38283136
21cell adhesion mediated by integrin (GO:0033627)3.37629235
22interferon-gamma-mediated signaling pathway (GO:0060333)3.32129054
23detection of molecule of bacterial origin (GO:0032490)3.29944710
24positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29268115
25apoptotic cell clearance (GO:0043277)3.27934571
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26526687
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26526687
28detection of external biotic stimulus (GO:0098581)3.22156432
29neutrophil activation (GO:0042119)3.13926895
30positive regulation of p38MAPK cascade (GO:1900745)3.12853570
31granulocyte activation (GO:0036230)3.11365013
32defense response to protozoan (GO:0042832)3.08971389
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08422287
34leukocyte aggregation (GO:0070486)3.04914432
35regulation of membrane protein ectodomain proteolysis (GO:0051043)3.01662310
36macrophage activation (GO:0042116)3.00388692
37T-helper 1 type immune response (GO:0042088)2.99509476
38antigen processing and presentation of endogenous antigen (GO:0019883)2.98874749
39hemidesmosome assembly (GO:0031581)2.98863700
40negative regulation of lymphocyte mediated immunity (GO:0002707)2.98091953
41response to protozoan (GO:0001562)2.94689965
42regulation of T cell tolerance induction (GO:0002664)2.94211754
43myeloid cell activation involved in immune response (GO:0002275)2.94058372
44low-density lipoprotein particle clearance (GO:0034383)2.93161642
45negative regulation of T cell mediated immunity (GO:0002710)2.92712821
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91698466
47growth hormone receptor signaling pathway (GO:0060396)2.90156465
48microglial cell activation (GO:0001774)2.90087686
49regulation of cholesterol storage (GO:0010885)2.88649825
50response to interleukin-15 (GO:0070672)2.88401405
51regulation of tolerance induction (GO:0002643)2.86227357
52detection of biotic stimulus (GO:0009595)2.84492637
53tolerance induction (GO:0002507)2.84487418
54negative regulation of cytokine production involved in immune response (GO:0002719)2.83791635
55regulation of cholesterol homeostasis (GO:2000188)2.80068374
56protein localization to endosome (GO:0036010)2.79054736
57regulation of T-helper 1 cell differentiation (GO:0045625)2.79043534
58positive regulation of cellular amide metabolic process (GO:0034250)2.77802012
59regulation of mast cell degranulation (GO:0043304)2.77088576
60production of molecular mediator involved in inflammatory response (GO:0002532)2.74161637
61regulation of interferon-beta biosynthetic process (GO:0045357)2.73877978
62response to laminar fluid shear stress (GO:0034616)2.73690002
63regulation of T-helper 2 cell differentiation (GO:0045628)2.73551308
64B cell mediated immunity (GO:0019724)2.72278481
65negative regulation of leukocyte mediated immunity (GO:0002704)2.71841420
66positive regulation of type 2 immune response (GO:0002830)2.71163636
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.71081106
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.69099814
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68592299
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67986386
71NIK/NF-kappaB signaling (GO:0038061)2.67898105
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67804177
73cellular response to interleukin-15 (GO:0071350)2.67624603
74macrophage activation involved in immune response (GO:0002281)2.67393559
75negative regulation of erythrocyte differentiation (GO:0045647)2.67218449
76regulation of antigen processing and presentation (GO:0002577)2.66164686
77positive regulation of histone deacetylation (GO:0031065)2.65895126
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65767952
79negative regulation of innate immune response (GO:0045824)2.65019523
80negative regulation of interleukin-6 production (GO:0032715)2.64503193
81regulation of p38MAPK cascade (GO:1900744)2.62143876
82negative regulation of T-helper cell differentiation (GO:0045623)2.59359380
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59359380
84positive regulation of tolerance induction (GO:0002645)2.59301406
85positive regulation of antigen processing and presentation (GO:0002579)2.58605234
86plasma membrane repair (GO:0001778)2.58472188
87myeloid dendritic cell differentiation (GO:0043011)2.58082442
88regulation of vitamin D biosynthetic process (GO:0060556)2.57719265
89T cell migration (GO:0072678)2.56505138
90regulation of T cell mediated cytotoxicity (GO:0001914)2.55665043
91negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55555852
92regulation of mast cell activation involved in immune response (GO:0033006)2.55316832
93regulation of mast cell activation (GO:0033003)2.54437679
94negative regulation of fatty acid transport (GO:2000192)2.53157917
95positive regulation of mast cell activation (GO:0033005)2.53131271
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.52097737
97regulation of regulatory T cell differentiation (GO:0045589)2.51762453
98B cell receptor signaling pathway (GO:0050853)2.50900577
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50363586
100positive regulation of interferon-alpha production (GO:0032727)2.50235674
101regulation of interleukin-12 production (GO:0032655)2.50028948
102respiratory burst (GO:0045730)2.49550623
103endodermal cell differentiation (GO:0035987)2.49539892
104regulation of interleukin-8 biosynthetic process (GO:0045414)2.48787715
105skin morphogenesis (GO:0043589)2.47988433
106cellular response to interferon-gamma (GO:0071346)2.47579202
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47525479
108positive regulation of toll-like receptor signaling pathway (GO:0034123)2.47384138
109cellular response to growth hormone stimulus (GO:0071378)2.46630444
110regulation of gamma-delta T cell differentiation (GO:0045586)2.45235587
111cell-substrate junction assembly (GO:0007044)2.42859529
112regulation of interferon-alpha production (GO:0032647)2.40580362
113positive regulation of gamma-delta T cell activation (GO:0046645)2.39290820
114epithelial cell-cell adhesion (GO:0090136)2.38800332
115regulation of gamma-delta T cell activation (GO:0046643)2.33905018
116positive regulation of lipid storage (GO:0010884)2.32629145
117adhesion of symbiont to host cell (GO:0044650)2.29287640
118virion attachment to host cell (GO:0019062)2.29287640
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29277642
120response to host (GO:0075136)2.29277642
121response to host defenses (GO:0052200)2.29277642
122basement membrane organization (GO:0071711)2.28986549
123positive regulation of natural killer cell differentiation (GO:0032825)2.25038818
124response to host immune response (GO:0052572)2.24781397
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.24781397
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23615200
127regulation of podosome assembly (GO:0071801)2.21781278
128cellular response to interferon-alpha (GO:0035457)2.21315011
129adhesion of symbiont to host (GO:0044406)2.20502045
130regulation of macrophage cytokine production (GO:0010935)2.19255888
131establishment of endothelial barrier (GO:0061028)2.17724291
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.14169140
133vascular endothelial growth factor signaling pathway (GO:0038084)2.13908954
134lipopolysaccharide-mediated signaling pathway (GO:0031663)2.13234022
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.12478701
136cell migration involved in sprouting angiogenesis (GO:0002042)2.12381954
137response to fluid shear stress (GO:0034405)2.12267833
138positive regulation of chemokine biosynthetic process (GO:0045080)2.12009046
139lysine metabolic process (GO:0006553)2.11131913
140lysine catabolic process (GO:0006554)2.11131913
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.10627946
142I-kappaB phosphorylation (GO:0007252)2.10444382
143response to muramyl dipeptide (GO:0032495)2.10329663
144wound healing, spreading of epidermal cells (GO:0035313)2.09009426
145protein carboxylation (GO:0018214)2.08564475
146peptidyl-glutamic acid carboxylation (GO:0017187)2.08564475
147regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.06373777
148cytoskeletal anchoring at plasma membrane (GO:0007016)2.05883482
149positive regulation of macrophage cytokine production (GO:0060907)2.04040681
150negative regulation of lipid transport (GO:0032369)2.03830181
151positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.03595157
152positive regulation of fatty acid beta-oxidation (GO:0032000)2.03583429
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.02696498
154stress fiber assembly (GO:0043149)2.01919453
155regulation of integrin activation (GO:0033623)2.01617779
156blood vessel endothelial cell migration (GO:0043534)2.00596347
157cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.99928348
158positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)1.99852975
159negative regulation of lipid storage (GO:0010888)1.99796574
160negative regulation of interleukin-12 production (GO:0032695)1.99081870
161desmosome organization (GO:0002934)1.97723726
162response to growth hormone (GO:0060416)1.97544497
163endothelial cell chemotaxis (GO:0035767)1.97284401
164negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.97252796
165plasma lipoprotein particle clearance (GO:0034381)1.96075855
166substrate-dependent cell migration (GO:0006929)1.95737719
167positive thymic T cell selection (GO:0045059)1.95485491
1684-hydroxyproline metabolic process (GO:0019471)1.95077731
169phospholipid homeostasis (GO:0055091)1.94701508
170positive regulation of triglyceride biosynthetic process (GO:0010867)1.93871347
171positive regulation of reactive oxygen species metabolic process (GO:2000379)1.93191844
172pinocytosis (GO:0006907)1.92761566
173regulation of fatty acid beta-oxidation (GO:0031998)1.92234917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.22072232
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.59120159
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88754416
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71587611
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.66464897
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.57601528
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54951085
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49000632
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.47145538
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.46662447
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.37162878
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32236741
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29181731
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25529326
15CLOCK_20551151_ChIP-Seq_293T_Human2.25250051
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25015156
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21140385
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21108715
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.19282124
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.13028895
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11522130
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08264250
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95909968
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.93836681
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93112811
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91533496
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89723697
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.89496114
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.88959270
30SCL_19346495_ChIP-Seq_HPC-7_Human1.86647954
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84591694
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81489801
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77919841
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.77619321
35SPI1_23547873_ChIP-Seq_NB4_Human1.76594734
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76464153
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.74981980
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.69445781
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67795559
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66961812
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63906108
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58875485
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57298927
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57285112
45ZNF263_19887448_ChIP-Seq_K562_Human1.55385640
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54530298
47MYB_26560356_Chip-Seq_TH1_Human1.54037036
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53297058
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.52006514
50TCF7_22412390_ChIP-Seq_EML_Mouse1.51844338
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51436167
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50542926
53KDM2B_26808549_Chip-Seq_DND41_Human1.49375389
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48910787
55RACK7_27058665_Chip-Seq_MCF-7_Human1.48671261
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48097270
57GATA3_27048872_Chip-Seq_THYMUS_Human1.45504478
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.44785067
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42903548
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42837346
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40063328
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38773738
63LXR_22292898_ChIP-Seq_THP-1_Human1.38676237
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38458959
65RUNX_20019798_ChIP-Seq_JUKART_Human1.37709747
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37009466
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35130507
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33647614
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31430093
70MAF_26560356_Chip-Seq_TH1_Human1.31073315
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28461640
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28438173
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27008514
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.26979447
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.26979447
76GATA1_19941826_ChIP-Seq_K562_Human1.26035264
77ATF3_27146783_Chip-Seq_COLON_Human1.25881941
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25763262
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25561990
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25330227
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24895120
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24828443
83PU_27001747_Chip-Seq_BMDM_Mouse1.24798839
84GATA3_26560356_Chip-Seq_TH2_Human1.24602342
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24128438
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23301902
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23301902
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22581211
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22504144
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.22030385
91SPI1_23127762_ChIP-Seq_K562_Human1.18815875
92CJUN_26792858_Chip-Seq_BT549_Human1.17559082
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17542204
94GATA1_22025678_ChIP-Seq_K562_Human1.17332305
95VDR_21846776_ChIP-Seq_THP-1_Human1.14864510
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11682254
97MYC_22102868_ChIP-Seq_BL_Human1.11444427
98GATA2_19941826_ChIP-Seq_K562_Human1.10857430
99KDM2B_26808549_Chip-Seq_K562_Human1.10149416
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.10036213
101VDR_24763502_ChIP-Seq_THP-1_Human1.09193826
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07326572
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07245769
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06934942
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06244771
106SOX2_20726797_ChIP-Seq_SW620_Human1.06130829
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04863416
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04538792
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04275721
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.04052263
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04043201
112GATA6_25053715_ChIP-Seq_YYC3_Human1.03119934
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02523376
114VDR_24787735_ChIP-Seq_THP-1_Human1.00149641
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.99328079
116MYB_26560356_Chip-Seq_TH2_Human0.98945376
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.98649884
118UTX_26944678_Chip-Seq_JUKART_Human0.98464367
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98059993
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.97997012
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.97514720
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97011541
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96811972
124MAF_26560356_Chip-Seq_TH2_Human0.95475003
125CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95406332
126NCOR1_26117541_ChIP-Seq_K562_Human0.93235860
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93079609
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93028370
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92861114
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92808546
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92317108
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92234929
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90984923
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90223514
135SMRT_27268052_Chip-Seq_Bcells_Human0.87136130
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85219228
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83798208
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80283165
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77347077
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74227731
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74195887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.48128088
2MP0003300_gastrointestinal_ulcer2.95220103
3MP0005671_abnormal_response_to2.83742153
4MP0003303_peritoneal_inflammation2.58228894
5MP0008438_abnormal_cutaneous_collagen2.51688612
6MP0003566_abnormal_cell_adhesion2.30464060
7MP0009840_abnormal_foam_cell2.24709826
8MP0010352_gastrointestinal_tract_polyps2.12620311
9MP0003191_abnormal_cellular_cholesterol2.09933151
10MP0002420_abnormal_adaptive_immunity2.09561149
11MP0001819_abnormal_immune_cell2.08407836
12MP0003436_decreased_susceptibility_to2.02849883
13MP0005275_abnormal_skin_tensile2.01783851
14MP0010234_abnormal_vibrissa_follicle1.99947557
15MP0004510_myositis1.97260663
16MP0004947_skin_inflammation1.84943402
17MP0003763_abnormal_thymus_physiology1.76984903
18MP0005360_urolithiasis1.76198777
19MP0003045_fibrosis1.75203768
20MP0005058_abnormal_lysosome_morphology1.72303588
21MP0001958_emphysema1.68489367
22MP0005076_abnormal_cell_differentiation1.67610154
23MP0005023_abnormal_wound_healing1.65026775
24MP0000685_abnormal_immune_system1.63593374
25MP0003453_abnormal_keratinocyte_physiol1.58986732
26MP0002254_reproductive_system_inflammat1.55294567
27MP0005310_abnormal_salivary_gland1.54007411
28MP0009278_abnormal_bone_marrow1.53220837
29MP0000716_abnormal_immune_system1.53177296
30MP0006082_CNS_inflammation1.49516076
31MP0003279_aneurysm1.47793136
32MP0003091_abnormal_cell_migration1.47320338
33MP0001790_abnormal_immune_system1.47115697
34MP0005387_immune_system_phenotype1.47115697
35MP0003183_abnormal_peptide_metabolism1.47103020
36MP0000343_altered_response_to1.46186462
37MP0001533_abnormal_skeleton_physiology1.45740824
38MP0009785_altered_susceptibility_to1.43887962
39MP0003724_increased_susceptibility_to1.42713237
40MP0000465_gastrointestinal_hemorrhage1.42460179
41MP0002398_abnormal_bone_marrow1.40784480
42MP0009333_abnormal_splenocyte_physiolog1.39779559
43MP0002139_abnormal_hepatobiliary_system1.36872944
44MP0003866_abnormal_defecation1.36743558
45MP0001835_abnormal_antigen_presentation1.35752934
46MP0004272_abnormal_basement_membrane1.33967437
47MP0002419_abnormal_innate_immunity1.31236758
48MP0003448_altered_tumor_morphology1.30739113
49MP0002877_abnormal_melanocyte_morpholog1.29130581
50MP0000604_amyloidosis1.28164568
51MP0008004_abnormal_stomach_pH1.27391723
52MP0004858_abnormal_nervous_system1.26764576
53MP0005397_hematopoietic_system_phenotyp1.26515459
54MP0001545_abnormal_hematopoietic_system1.26515459
55MP0005451_abnormal_body_composition1.26228815
56MP0010155_abnormal_intestine_physiology1.26220205
57MP0005000_abnormal_immune_tolerance1.26166805
58MP0000733_abnormal_muscle_development1.25941913
59MP0005083_abnormal_biliary_tract1.24732473
60MP0002166_altered_tumor_susceptibility1.23541172
61MP0003195_calcinosis1.22580057
62MP0004084_abnormal_cardiac_muscle1.22425517
63MP0002060_abnormal_skin_morphology1.21311840
64MP0000689_abnormal_spleen_morphology1.20674916
65MP0003252_abnormal_bile_duct1.20593131
66MP0004130_abnormal_muscle_cell1.20430390
67MP0002998_abnormal_bone_remodeling1.17457302
68MP0003075_altered_response_to1.17382314
69MP0003828_pulmonary_edema1.16783829
70MP0005025_abnormal_response_to1.16312457
71MP0000858_altered_metastatic_potential1.16179661
72MP0008961_abnormal_basal_metabolism1.14972053
73MP0002138_abnormal_hepatobiliary_system1.13636574
74MP0002429_abnormal_blood_cell1.13521666
75MP0009764_decreased_sensitivity_to1.12110543
76MP0002722_abnormal_immune_system1.11202745
77MP0001849_ear_inflammation1.10617352
78MP0004883_abnormal_blood_vessel1.10125631
79MP0003690_abnormal_glial_cell1.09715653
80MP0003172_abnormal_lysosome_physiology1.08797599
81MP0002796_impaired_skin_barrier1.08609170
82MP0005167_abnormal_blood-brain_barrier1.07900875
83MP0003656_abnormal_erythrocyte_physiolo1.06752531
84MP0000609_abnormal_liver_physiology1.04820266
85MP0005464_abnormal_platelet_physiology1.03630830
86MP0000750_abnormal_muscle_regeneration1.03330386
87MP0001845_abnormal_inflammatory_respons1.03055046
88MP0001851_eye_inflammation1.02712172
89MP0002168_other_aberrant_phenotype1.02609645
90MP0002405_respiratory_system_inflammati1.02132067
91MP0002277_abnormal_respiratory_mucosa1.01533682
92MP0005166_decreased_susceptibility_to1.00808734
93MP0008260_abnormal_autophagy1.00267171
94MP0002006_tumorigenesis1.00235672
95MP0002452_abnormal_antigen_presenting1.00036435
96MP0001853_heart_inflammation1.00013341
97MP0004185_abnormal_adipocyte_glucose0.99578610
98MP0002148_abnormal_hypersensitivity_rea0.99190845
99MP0004087_abnormal_muscle_fiber0.99013241
100MP0001800_abnormal_humoral_immune0.97876283
101MP0010630_abnormal_cardiac_muscle0.94954697
102MP0002132_abnormal_respiratory_system0.92427524
103MP0010329_abnormal_lipoprotein_level0.92361917
104MP0000767_abnormal_smooth_muscle0.92278732
105MP0008469_abnormal_protein_level0.91739062
106MP0006054_spinal_hemorrhage0.90354709
107MP0009643_abnormal_urine_homeostasis0.90225546
108MP0002723_abnormal_immune_serum0.90206255
109MP0001873_stomach_inflammation0.90087063
110MP0010368_abnormal_lymphatic_system0.90056932
111MP0002933_joint_inflammation0.89125790
112MP0002332_abnormal_exercise_endurance0.89027771
113MP0005666_abnormal_adipose_tissue0.88566365
114MP0009384_cardiac_valve_regurgitation0.88393547
115MP0002136_abnormal_kidney_physiology0.84815388
116MP0000249_abnormal_blood_vessel0.83951880
117MP0005623_abnormal_meninges_morphology0.83789413
118MP0005390_skeleton_phenotype0.83527400
119MP0009763_increased_sensitivity_to0.82957234
120MP0000751_myopathy0.82784502
121MP0005085_abnormal_gallbladder_physiolo0.82637842
122MP0005365_abnormal_bile_salt0.82494664
123MP0002837_dystrophic_cardiac_calcinosis0.82305513
124MP0005165_increased_susceptibility_to0.81942225
125MP0000703_abnormal_thymus_morphology0.81899756
126MP0004381_abnormal_hair_follicle0.81875260
127MP0005164_abnormal_response_to0.81343620
128MP0008875_abnormal_xenobiotic_pharmacok0.80772401
129MP0010307_abnormal_tumor_latency0.80623528
130MP0005319_abnormal_enzyme/_coenzyme0.80474884
131MP0001663_abnormal_digestive_system0.79180857
132MP0002693_abnormal_pancreas_physiology0.78469093
133MP0001881_abnormal_mammary_gland0.76883517
134MP0003795_abnormal_bone_structure0.76594885
135MP0005535_abnormal_body_temperature0.67937173
136MP0009765_abnormal_xenobiotic_induced0.67718536
137MP0001501_abnormal_sleep_pattern0.66374285
138MP0008874_decreased_physiological_sensi0.60635075
139MP0000920_abnormal_myelination0.60075539
140MP0004808_abnormal_hematopoietic_stem0.57860284
141MP0000015_abnormal_ear_pigmentation0.57553983

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.68624431
2Optic neuritis (HP:0100653)4.68624431
3Stomatitis (HP:0010280)4.57132648
4Abnormality of glycolipid metabolism (HP:0010969)4.21228765
5Abnormality of liposaccharide metabolism (HP:0010968)4.21228765
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.21228765
7Mediastinal lymphadenopathy (HP:0100721)3.59123032
8Recurrent fungal infections (HP:0002841)3.41139580
9Vasculitis (HP:0002633)3.38794621
10Eczematoid dermatitis (HP:0000976)3.35847358
11Right ventricular cardiomyopathy (HP:0011663)3.30726832
12Keratoconjunctivitis sicca (HP:0001097)3.25738849
13Gastrointestinal infarctions (HP:0005244)3.25715767
14Recurrent skin infections (HP:0001581)3.19974125
15Pulmonary infiltrates (HP:0002113)3.19517658
16Cerebral aneurysm (HP:0004944)3.17890886
17Hemoptysis (HP:0002105)3.08788294
18Keratoconjunctivitis (HP:0001096)3.07981529
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.06759095
20Meningitis (HP:0001287)3.06379268
21Protrusio acetabuli (HP:0003179)3.04408777
22Recurrent cutaneous fungal infections (HP:0011370)2.93532746
23Chronic mucocutaneous candidiasis (HP:0002728)2.93532746
24Premature rupture of membranes (HP:0001788)2.91698845
25Myocardial infarction (HP:0001658)2.89952575
26Peritonitis (HP:0002586)2.86966283
27Interstitial pulmonary disease (HP:0006530)2.85806281
28Loss of speech (HP:0002371)2.85239951
29Chronic obstructive pulmonary disease (HP:0006510)2.83257111
30Obstructive lung disease (HP:0006536)2.83257111
31T lymphocytopenia (HP:0005403)2.75373025
32Hyporeflexia of lower limbs (HP:0002600)2.74252730
33Abnormality of T cell number (HP:0011839)2.73639064
34Broad metatarsal (HP:0001783)2.70807265
35Encephalitis (HP:0002383)2.69718626
36Hematochezia (HP:0002573)2.68032577
37Increased connective tissue (HP:0009025)2.64289131
38Malnutrition (HP:0004395)2.62700582
39Increased cerebral lipofuscin (HP:0011813)2.58874960
40Atrophic scars (HP:0001075)2.55982565
41Episodic fever (HP:0001954)2.55797691
42Chest pain (HP:0100749)2.53752423
43Urticaria (HP:0001025)2.53557527
44Aortic aneurysm (HP:0004942)2.50844471
45Shallow orbits (HP:0000586)2.49798069
46Recurrent viral infections (HP:0004429)2.49737869
47Leukocytosis (HP:0001974)2.47035625
48Cervical subluxation (HP:0003308)2.45803153
49Pustule (HP:0200039)2.44074472
50Esophageal varix (HP:0002040)2.43033343
51Pulmonary embolism (HP:0002204)2.42802186
52Osteolytic defects of the hand bones (HP:0009699)2.39852398
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.39852398
54Axonal loss (HP:0003447)2.38629102
55Gangrene (HP:0100758)2.35639005
56Systemic lupus erythematosus (HP:0002725)2.34527052
57Autoimmune hemolytic anemia (HP:0001890)2.33796948
58Aneurysm (HP:0002617)2.33267079
59Prolonged bleeding time (HP:0003010)2.31366561
60Petechiae (HP:0000967)2.30888495
61Chronic diarrhea (HP:0002028)2.28983559
62Recurrent bronchitis (HP:0002837)2.27385024
63Abnormality of proline metabolism (HP:0010907)2.27289621
64Hydroxyprolinuria (HP:0003080)2.27289621
65Asymmetric septal hypertrophy (HP:0001670)2.27272089
66Recurrent gram-negative bacterial infections (HP:0005420)2.27214824
67Aortic dissection (HP:0002647)2.26240855
68Exercise-induced muscle cramps (HP:0003710)2.25994160
69Polycythemia (HP:0001901)2.25776767
70Abnormality of the pleura (HP:0002103)2.25525366
71Deep venous thrombosis (HP:0002625)2.23406765
72Autoimmune thrombocytopenia (HP:0001973)2.23051218
73Osteomyelitis (HP:0002754)2.21864481
74Anorexia (HP:0002039)2.21235610
75Increased IgM level (HP:0003496)2.20847628
76Xanthomatosis (HP:0000991)2.20070153
77Gingival bleeding (HP:0000225)2.19477437
78Frequent falls (HP:0002359)2.18162064
79Mitral valve prolapse (HP:0001634)2.17617844
80Mucopolysacchariduria (HP:0008155)2.17507234
81Urinary glycosaminoglycan excretion (HP:0003541)2.17507234
82Hypergammaglobulinemia (HP:0010702)2.16374441
83Recurrent abscess formation (HP:0002722)2.16131465
84Gastrointestinal stroma tumor (HP:0100723)2.15965438
85Ventricular tachycardia (HP:0004756)2.14552900
86Disinhibition (HP:0000734)2.14038261
87Joint swelling (HP:0001386)2.13817309
88Orchitis (HP:0100796)2.13106948
89Dysostosis multiplex (HP:0000943)2.12845531
90Muscle fiber splitting (HP:0003555)2.12642459
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12000882
92Inflammation of the large intestine (HP:0002037)2.11610443
93Upper limb amyotrophy (HP:0009129)2.11060881
94Distal upper limb amyotrophy (HP:0007149)2.11060881
95Abnormality of T cells (HP:0002843)2.10700220
96Abnormality of the nasal mucosa (HP:0000433)2.08718721
97Nephritis (HP:0000123)2.08112432
98Polyneuropathy (HP:0001271)2.08097060
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07825266
100Ankle contracture (HP:0006466)2.07471788
101Cellulitis (HP:0100658)2.07108021
102Increased density of long bones (HP:0006392)2.07071713
103Thin bony cortex (HP:0002753)2.06803797
104Epistaxis (HP:0000421)2.06498196
105Acne (HP:0001061)2.05983439
106Difficulty climbing stairs (HP:0003551)2.05811064
107Premature loss of primary teeth (HP:0006323)2.05654029
108Vacuolated lymphocytes (HP:0001922)2.03750928
109Difficulty running (HP:0009046)2.01770464
110Restrictive lung disease (HP:0002091)2.01718648
111Tetraparesis (HP:0002273)2.01006374
112Dilatation of the ascending aorta (HP:0005111)2.00722587
113Purpura (HP:0000979)2.00368848
114Myositis (HP:0100614)1.99645071
115Complement deficiency (HP:0004431)1.98326299
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98013885
117Abnormality of polysaccharide metabolism (HP:0011012)1.98013885
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98013885
119Elevated erythrocyte sedimentation rate (HP:0003565)1.97859286
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.97349543
121Flat acetabular roof (HP:0003180)1.96458724
122Recurrent bacterial skin infections (HP:0005406)1.95750210
123Thick nail (HP:0001805)1.95396743
124Alopecia of scalp (HP:0002293)1.94667297
125Gastrointestinal inflammation (HP:0004386)1.94028380
126Granulocytopenia (HP:0001913)1.93310291
127Vertigo (HP:0002321)1.92668348
128Abnormality of macrophages (HP:0004311)1.92625239
129Eosinophilia (HP:0001880)1.91162765
130Increased serum ferritin (HP:0003281)1.91125634
131Basal ganglia calcification (HP:0002135)1.88251127
132Hand muscle atrophy (HP:0009130)1.86899181
133Mitral stenosis (HP:0001718)1.86358630
134Lymphopenia (HP:0001888)1.85746861
135Keratitis (HP:0000491)1.85464899
136Arthralgia (HP:0002829)1.84654778
137Progressive neurologic deterioration (HP:0002344)1.84532510
138Colitis (HP:0002583)1.84041183
139Nasal polyposis (HP:0100582)1.83622884
140Mutism (HP:0002300)1.82782238
141Ulnar bowing (HP:0003031)1.82074115
142Fragile skin (HP:0001030)1.81581181
143Arterial thrombosis (HP:0004420)1.80200849
144Increased IgE level (HP:0003212)1.80016335
145Abnormality of the pericardium (HP:0001697)1.79881984
146Vertebral compression fractures (HP:0002953)1.79811253
147Sudden death (HP:0001699)1.79589915
148Increased CSF protein (HP:0002922)1.79219791
149Gingivitis (HP:0000230)1.78613695
150Persistence of primary teeth (HP:0006335)1.76898413
151Hemorrhage of the eye (HP:0011885)1.75093752
152Periodontitis (HP:0000704)1.74802175
153Abnormality of the Achilles tendon (HP:0005109)1.74061672
154Type 1 muscle fiber predominance (HP:0003803)1.73549479
155Abnormality of complement system (HP:0005339)1.72616765
156Milia (HP:0001056)1.71328354
157Achilles tendon contracture (HP:0001771)1.67839984
158Striae distensae (HP:0001065)1.67560791
159Lymphangioma (HP:0100764)1.67475261
160Spontaneous hematomas (HP:0007420)1.66368449
161Disproportionate tall stature (HP:0001519)1.65287894
162Ulnar deviation of the wrist (HP:0003049)1.64285037
163Distal lower limb muscle weakness (HP:0009053)1.63981505
164Amyloidosis (HP:0011034)1.63115062
165Glomerulonephritis (HP:0000099)1.62054563
166Distal lower limb amyotrophy (HP:0008944)1.61164046
167Long toe (HP:0010511)1.60419246
168Arterial tortuosity (HP:0005116)1.60278704
169Genu recurvatum (HP:0002816)1.59049257
170Skin nodule (HP:0200036)1.59022346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.59921519
2TRIB33.50368936
3TTN3.01411740
4EPHB12.53039107
5FGFR42.52536325
6PKN22.44558802
7IRAK42.42568051
8RIPK12.38254371
9PRPF4B2.25775062
10TYK21.97301236
11TGFBR21.97069722
12PTK61.96958453
13SIK11.91618855
14TBK11.90039590
15CDK121.76175485
16EPHA31.75080110
17FES1.74526891
18JAK11.72229829
19MAP3K141.68399308
20STK101.62242898
21MAP4K11.59691757
22LRRK21.58586097
23LATS11.57758107
24BMPR21.56657159
25EPHA21.54868060
26PDGFRA1.52481243
27IRAK11.45486753
28FGFR31.43668398
29FGR1.41356491
30MAP3K101.39952002
31TNK21.37736378
32DMPK1.35056652
33SIK31.34238097
34SYK1.33761186
35BMX1.33082042
36GRK71.31424860
37MAP3K31.29206110
38BTK1.27874830
39CSK1.26957463
40CDC42BPA1.26865279
41FRK1.25390483
42NEK91.22999879
43JAK31.22094435
44LYN1.19564779
45PTK21.15282044
46CAMK1D1.14218485
47IKBKE1.12684596
48MAP2K31.12379418
49JAK21.08557226
50ZAP701.07249115
51EEF2K1.04756538
52MAP3K111.03076098
53CHUK1.02326309
54FER1.01790779
55TAOK21.01580958
56MAP3K70.99455648
57DDR20.97331985
58NLK0.96019145
59PDGFRB0.95778570
60RIPK40.94578161
61CDK60.91237567
62IKBKB0.89605142
63HIPK20.89096330
64CAMK1G0.88875815
65PAK40.88834327
66IRAK20.88535518
67HCK0.88504578
68ITK0.87552299
69MATK0.86061088
70STK240.84350769
71TRPM70.83656428
72KIT0.83333930
73RET0.82582960
74LMTK20.81776362
75STK30.81671517
76TEC0.80513389
77BLK0.79823025
78YES10.77871499
79EPHB20.77383555
80PDK10.77131857
81IRAK30.76991665
82KSR20.73115659
83MTOR0.72021010
84DYRK1B0.70170797
85DAPK20.69357607
86MAPK70.68777977
87GRK60.68483217
88PRKCH0.67044769
89TAOK30.67000829
90MAP3K20.65425618
91ACVR1B0.64857646
92PRKD20.64322715
93MAP3K10.63763047
94MARK20.61899656
95RPS6KA40.59947780
96PRKCQ0.59588604
97MAPKAPK30.59425349
98PAK20.59222445
99ADRBK20.59079138
100TAOK10.58068817
101EGFR0.57203288
102MARK30.57160400
103PRKD10.56514785
104TYRO30.56115068
105GSK3A0.55816582
106MAPK120.55411469
107PAK30.55257941
108ALK0.54805318
109MAP3K130.54780493
110SGK20.54749744
111MST40.54069309
112PIM10.52158601
113MAP2K60.50568812
114INSRR0.49997048
115PRKAA20.48998675
116PIM20.48894562
117PIK3CG0.48552024
118MOS0.46937598
119PRKG20.46491427
120ABL10.46445038
121MST1R0.46129535
122MAP3K50.46015494
123SGK30.45533251
124CSF1R0.44071770
125LCK0.43406233
126MAP2K10.43390123
127FYN0.41867620
128FGFR10.41237079
129PDPK10.40399433
130MAPK110.40183598
131STK380.39763589
132PIK3CA0.39478934
133FLT30.39315771
134PTK2B0.38802879
135TXK0.38189496
136INSR0.37347494
137MAP2K20.37030011
138ERBB20.36860334
139CAMKK20.35450067
140MAPKAPK20.33709669
141STK110.29063189
142SIK20.27422489

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.52784868
2Graft-versus-host disease_Homo sapiens_hsa053322.45037660
3Type I diabetes mellitus_Homo sapiens_hsa049402.24655840
4Autoimmune thyroid disease_Homo sapiens_hsa053202.20999090
5Staphylococcus aureus infection_Homo sapiens_hsa051502.04102358
6Leishmaniasis_Homo sapiens_hsa051401.97083884
7Asthma_Homo sapiens_hsa053101.88780163
8Osteoclast differentiation_Homo sapiens_hsa043801.73737192
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62649518
10Caffeine metabolism_Homo sapiens_hsa002321.61523370
11Nitrogen metabolism_Homo sapiens_hsa009101.56024856
12Primary immunodeficiency_Homo sapiens_hsa053401.53228929
13Toxoplasmosis_Homo sapiens_hsa051451.51386810
14Malaria_Homo sapiens_hsa051441.51145195
15Amoebiasis_Homo sapiens_hsa051461.47301725
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38791959
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36364411
18Fatty acid degradation_Homo sapiens_hsa000711.33884283
19TNF signaling pathway_Homo sapiens_hsa046681.33319212
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.30234325
21ECM-receptor interaction_Homo sapiens_hsa045121.29762540
22Lysosome_Homo sapiens_hsa041421.28048105
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.27667158
24Complement and coagulation cascades_Homo sapiens_hsa046101.26964223
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.26227496
26Herpes simplex infection_Homo sapiens_hsa051681.23730421
27Focal adhesion_Homo sapiens_hsa045101.23584519
28Insulin resistance_Homo sapiens_hsa049311.22659403
29Viral myocarditis_Homo sapiens_hsa054161.20683031
30Legionellosis_Homo sapiens_hsa051341.18097588
31Adherens junction_Homo sapiens_hsa045201.18096246
32Pertussis_Homo sapiens_hsa051331.17841084
33Arginine biosynthesis_Homo sapiens_hsa002201.17257757
34Proteoglycans in cancer_Homo sapiens_hsa052051.17010755
35Tuberculosis_Homo sapiens_hsa051521.16787424
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16468262
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16201185
38Chronic myeloid leukemia_Homo sapiens_hsa052201.14991894
39PPAR signaling pathway_Homo sapiens_hsa033201.14310308
40Small cell lung cancer_Homo sapiens_hsa052221.13930099
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.11338565
42B cell receptor signaling pathway_Homo sapiens_hsa046621.04587044
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03924595
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03646967
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01130724
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99445166
47Salmonella infection_Homo sapiens_hsa051320.98010894
48Measles_Homo sapiens_hsa051620.97502435
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96110576
50Acute myeloid leukemia_Homo sapiens_hsa052210.94234545
51Bile secretion_Homo sapiens_hsa049760.94095431
52Dilated cardiomyopathy_Homo sapiens_hsa054140.92757602
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91585195
54Pancreatic cancer_Homo sapiens_hsa052120.91379217
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90833900
56Influenza A_Homo sapiens_hsa051640.90029308
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89869177
58Bladder cancer_Homo sapiens_hsa052190.89219314
59Apoptosis_Homo sapiens_hsa042100.87428501
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87171783
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.83904904
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81425719
63Hepatitis C_Homo sapiens_hsa051600.81154909
64Shigellosis_Homo sapiens_hsa051310.80392632
65Fatty acid metabolism_Homo sapiens_hsa012120.80309904
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80263643
67Prolactin signaling pathway_Homo sapiens_hsa049170.79963833
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79831459
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77958241
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.77184786
71VEGF signaling pathway_Homo sapiens_hsa043700.76688456
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76011327
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75830348
74Tryptophan metabolism_Homo sapiens_hsa003800.75568524
75Lysine degradation_Homo sapiens_hsa003100.74181026
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72884097
77mTOR signaling pathway_Homo sapiens_hsa041500.71703873
78Hepatitis B_Homo sapiens_hsa051610.71348624
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70080161
80Other glycan degradation_Homo sapiens_hsa005110.69315468
81Starch and sucrose metabolism_Homo sapiens_hsa005000.68742146
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.67772686
83Antigen processing and presentation_Homo sapiens_hsa046120.67477125
84HIF-1 signaling pathway_Homo sapiens_hsa040660.67425079
85Platelet activation_Homo sapiens_hsa046110.67025010
86Type II diabetes mellitus_Homo sapiens_hsa049300.66949488
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66850068
88Collecting duct acid secretion_Homo sapiens_hsa049660.65894611
89T cell receptor signaling pathway_Homo sapiens_hsa046600.65478427
90Phagosome_Homo sapiens_hsa041450.64520766
91Rheumatoid arthritis_Homo sapiens_hsa053230.64218061
92Notch signaling pathway_Homo sapiens_hsa043300.62927656
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.62449577
94ABC transporters_Homo sapiens_hsa020100.62342761
95Hematopoietic cell lineage_Homo sapiens_hsa046400.62167033
96Mineral absorption_Homo sapiens_hsa049780.61772268
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60565479
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60467563
99Prion diseases_Homo sapiens_hsa050200.60229898
100Chemokine signaling pathway_Homo sapiens_hsa040620.59571966
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.59308337
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59267389
103MicroRNAs in cancer_Homo sapiens_hsa052060.58600597
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58526730
105Renal cell carcinoma_Homo sapiens_hsa052110.56835388
106Sphingolipid metabolism_Homo sapiens_hsa006000.56800977
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.56582099
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56264801
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55899820
110African trypanosomiasis_Homo sapiens_hsa051430.54960491
111Protein digestion and absorption_Homo sapiens_hsa049740.54378441
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54169226
113FoxO signaling pathway_Homo sapiens_hsa040680.54065501
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52040359
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51999968
116Non-small cell lung cancer_Homo sapiens_hsa052230.51668410
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.49201559
118GnRH signaling pathway_Homo sapiens_hsa049120.49127259
119Endocytosis_Homo sapiens_hsa041440.48227440
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.45410120
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44285863
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42749607
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42357736
124Epstein-Barr virus infection_Homo sapiens_hsa051690.42236277
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35188909
126MAPK signaling pathway_Homo sapiens_hsa040100.31201433
127Prostate cancer_Homo sapiens_hsa052150.31120160
128HTLV-I infection_Homo sapiens_hsa051660.31008633
129Regulation of autophagy_Homo sapiens_hsa041400.30921917
130Inositol phosphate metabolism_Homo sapiens_hsa005620.30623769
131Choline metabolism in cancer_Homo sapiens_hsa052310.30502468
132Endometrial cancer_Homo sapiens_hsa052130.26951105

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