SUZ12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.04511176
2nuclear pore organization (GO:0006999)4.96256415
3protein localization to kinetochore (GO:0034501)4.90735009
4mitotic metaphase plate congression (GO:0007080)4.73312046
5mitotic chromosome condensation (GO:0007076)4.44150065
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.42840365
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.42840365
8positive regulation of mitotic sister chromatid separation (GO:1901970)4.42840365
9mitotic sister chromatid segregation (GO:0000070)4.40000242
10regulation of sister chromatid cohesion (GO:0007063)4.39336615
11regulation of DNA endoreduplication (GO:0032875)4.34772527
12positive regulation of chromosome segregation (GO:0051984)4.34346830
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.29923582
14protein localization to chromosome, centromeric region (GO:0071459)4.29323985
15regulation of centriole replication (GO:0046599)4.22329518
16sister chromatid segregation (GO:0000819)4.20702118
17mitotic nuclear envelope disassembly (GO:0007077)4.19537878
18meiotic chromosome segregation (GO:0045132)4.18732902
19replication fork processing (GO:0031297)4.17434460
20kinetochore organization (GO:0051383)4.16074032
21metaphase plate congression (GO:0051310)4.13716550
22regulation of RNA export from nucleus (GO:0046831)4.13278368
23mitotic sister chromatid cohesion (GO:0007064)4.10534277
24DNA replication checkpoint (GO:0000076)4.04641294
25nuclear envelope disassembly (GO:0051081)3.94037213
26membrane disassembly (GO:0030397)3.94037213
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93916057
28DNA unwinding involved in DNA replication (GO:0006268)3.89460275
29pore complex assembly (GO:0046931)3.79777998
30DNA replication initiation (GO:0006270)3.75161018
31attachment of spindle microtubules to kinetochore (GO:0008608)3.72181681
32kinetochore assembly (GO:0051382)3.72046535
33regulation of spindle organization (GO:0090224)3.71632418
34establishment of chromosome localization (GO:0051303)3.71606993
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.71097327
36dosage compensation (GO:0007549)3.70892908
37negative regulation of histone methylation (GO:0031061)3.69942069
38chromosome condensation (GO:0030261)3.66384549
39protein K6-linked ubiquitination (GO:0085020)3.63916433
40DNA synthesis involved in DNA repair (GO:0000731)3.63323217
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61277865
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.61277865
43histone H2A monoubiquitination (GO:0035518)3.58535959
44double-strand break repair via nonhomologous end joining (GO:0006303)3.57997654
45non-recombinational repair (GO:0000726)3.57997654
46pre-miRNA processing (GO:0031054)3.57531173
47DNA strand elongation involved in DNA replication (GO:0006271)3.57064115
48negative regulation of DNA repair (GO:0045738)3.55725995
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55159348
50protein localization to chromosome (GO:0034502)3.53286027
51regulation of histone H3-K9 methylation (GO:0051570)3.49454032
52DNA replication-dependent nucleosome assembly (GO:0006335)3.49117118
53DNA replication-dependent nucleosome organization (GO:0034723)3.49117118
54DNA duplex unwinding (GO:0032508)3.46847269
55DNA geometric change (GO:0032392)3.45759257
56regulation of centrosome duplication (GO:0010824)3.43070379
57regulation of double-strand break repair (GO:2000779)3.42288699
58formation of translation preinitiation complex (GO:0001731)3.41811217
59heterochromatin organization (GO:0070828)3.41180736
60DNA packaging (GO:0006323)3.39541777
61DNA strand elongation (GO:0022616)3.38844047
62telomere maintenance via semi-conservative replication (GO:0032201)3.38737234
63chromosome segregation (GO:0007059)3.37391932
64mitotic recombination (GO:0006312)3.35238577
65regulation of chromosome segregation (GO:0051983)3.33340928
66telomere maintenance via recombination (GO:0000722)3.32252811
67chromatin remodeling at centromere (GO:0031055)3.29193191
68DNA replication-independent nucleosome organization (GO:0034724)3.26339342
69DNA replication-independent nucleosome assembly (GO:0006336)3.26339342
70positive regulation of histone H3-K4 methylation (GO:0051571)3.24672412
71V(D)J recombination (GO:0033151)3.23219046
72nuclear envelope organization (GO:0006998)3.22536118
73chromatin assembly (GO:0031497)3.21921256
74regulation of mitotic spindle organization (GO:0060236)3.21380890
75regulation of translational fidelity (GO:0006450)3.20979563
76DNA topological change (GO:0006265)3.20202576
77regulation of centrosome cycle (GO:0046605)3.19691118
78CENP-A containing nucleosome assembly (GO:0034080)3.18145449
79DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.17949576
80chromatin assembly or disassembly (GO:0006333)3.17676865
81DNA ligation (GO:0006266)3.16469132
82regulation of telomere maintenance via telomerase (GO:0032210)3.15122047
83embryonic process involved in female pregnancy (GO:0060136)3.14807648
84monoubiquitinated protein deubiquitination (GO:0035520)3.14524448
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12590749
86spindle checkpoint (GO:0031577)3.12369011
87synapsis (GO:0007129)3.12194885
88regulation of helicase activity (GO:0051095)3.12155399
89regulation of nucleobase-containing compound transport (GO:0032239)3.10861915
90establishment of integrated proviral latency (GO:0075713)3.08128204
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06556298
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.04555870
93DNA double-strand break processing (GO:0000729)3.04154588
94negative regulation of chromosome segregation (GO:0051985)3.03992879
95DNA damage response, signal transduction resulting in transcription (GO:0042772)3.03282306
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.02488073
97folic acid-containing compound biosynthetic process (GO:0009396)3.00151651
98mRNA transport (GO:0051028)2.99541212
99regulation of sister chromatid segregation (GO:0033045)2.99272338
100regulation of mitotic sister chromatid separation (GO:0010965)2.99272338
101regulation of mitotic sister chromatid segregation (GO:0033047)2.99272338
102nucleobase biosynthetic process (GO:0046112)2.98550183
103resolution of meiotic recombination intermediates (GO:0000712)2.98224060
104DNA conformation change (GO:0071103)2.97777616
105histone exchange (GO:0043486)2.96257280
106ATP-dependent chromatin remodeling (GO:0043044)2.95190119
107sister chromatid cohesion (GO:0007062)2.94217190
108cellular protein complex localization (GO:0034629)2.94187204
109maturation of SSU-rRNA (GO:0030490)2.94008262
110ribosome assembly (GO:0042255)2.92508796
111telomere maintenance via telomere lengthening (GO:0010833)2.91631780
112histone H4-K12 acetylation (GO:0043983)2.91381694
113regulation of gene silencing by RNA (GO:0060966)2.90407048
114regulation of posttranscriptional gene silencing (GO:0060147)2.90407048
115regulation of gene silencing by miRNA (GO:0060964)2.90407048
116mitotic G2/M transition checkpoint (GO:0044818)2.90337258
117ribosomal small subunit biogenesis (GO:0042274)2.89529917
118regulation of histone H3-K4 methylation (GO:0051569)2.87795340
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87793039
120mitotic G1 DNA damage checkpoint (GO:0031571)2.86552902
121ribosome biogenesis (GO:0042254)2.84298819
122maturation of 5.8S rRNA (GO:0000460)2.83724105
123regulation of histone H3-K27 methylation (GO:0061085)2.83398552
124ribonucleoprotein complex biogenesis (GO:0022613)2.82429272
125ribosomal large subunit biogenesis (GO:0042273)2.82331051
126mitotic spindle checkpoint (GO:0071174)2.82096906
127positive regulation of histone methylation (GO:0031062)2.81162996
128telomere maintenance (GO:0000723)2.80694272
129regulation of histone methylation (GO:0031060)2.80064582
130ribosomal small subunit assembly (GO:0000028)2.78771499
131telomere organization (GO:0032200)2.77012473
132negative regulation of mRNA metabolic process (GO:1903312)2.76927665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.50777367
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.06176669
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50298093
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38078722
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.71013529
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70849769
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64651076
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.56732247
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34387271
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.32929717
11AR_21909140_ChIP-Seq_LNCAP_Human2.29464325
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27547867
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.13116494
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07358115
15MYC_22102868_ChIP-Seq_BL_Human2.07069942
16E2F7_22180533_ChIP-Seq_HELA_Human10.0325755
17* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94056580
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93894501
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93894501
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93894501
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90666107
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89358306
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89020721
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88348507
25GATA1_22025678_ChIP-Seq_K562_Human1.86669459
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77218048
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76028389
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75454856
29* TP63_19390658_ChIP-ChIP_HaCaT_Human1.66352105
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65940994
31KDM5A_27292631_Chip-Seq_BREAST_Human1.65783769
32* XRN2_22483619_ChIP-Seq_HELA_Human1.64012304
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.63770179
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62832885
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62180503
36VDR_23849224_ChIP-Seq_CD4+_Human1.61389566
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.57428865
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57180969
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56955845
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52724293
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50965342
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48974608
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.48843605
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47646736
45* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45981900
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44416620
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41529160
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41170016
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41026048
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38255854
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38007786
52FOXP3_21729870_ChIP-Seq_TREG_Human1.36869166
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36409739
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36327293
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.35619412
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33999631
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33160326
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32796197
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31878142
60TTF2_22483619_ChIP-Seq_HELA_Human1.31647414
61GABP_19822575_ChIP-Seq_HepG2_Human1.31614268
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31166610
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30639493
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26825369
65* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24942029
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.24509057
67ELK1_19687146_ChIP-ChIP_HELA_Human1.24461487
68* DCP1A_22483619_ChIP-Seq_HELA_Human1.22364244
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21959121
70CIITA_25753668_ChIP-Seq_RAJI_Human1.21742547
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19507001
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18829873
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18756350
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18618028
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14842595
76TFEB_21752829_ChIP-Seq_HELA_Human1.14537323
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12152425
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11666598
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10591245
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09503068
81VDR_21846776_ChIP-Seq_THP-1_Human1.09488872
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08031385
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02981607
84EWS_26573619_Chip-Seq_HEK293_Human1.02665833
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02631113
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02166093
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00900953
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00573510
89MYB_26560356_Chip-Seq_TH2_Human1.00039120
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00025700
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99692936
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98102097
93* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97714655
94ZNF263_19887448_ChIP-Seq_K562_Human0.97411569
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96836140
96FUS_26573619_Chip-Seq_HEK293_Human0.96389850
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96216071
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96022550
99MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95969761
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95223148
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94622807
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94392646
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94345949
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94154332
105MYC_18940864_ChIP-ChIP_HL60_Human0.94152817
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93898294
107* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91724142
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91428012
109* CHD1_26751641_Chip-Seq_LNCaP_Human0.90358571
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89107813
111SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87350999
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86680392
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85518549
114NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85424069
115MYB_26560356_Chip-Seq_TH1_Human0.84626164
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83976637
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83283626
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82584430
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.81421633
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80309374
121SPI1_23547873_ChIP-Seq_NB4_Human0.77743864
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76569519
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75268455
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.75098396
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74719329
126SCL_19346495_ChIP-Seq_HPC-7_Human0.74032895
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70847453
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70451713
129ELF5_23300383_ChIP-Seq_T47D_Human0.65331013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.00604013
2MP0003693_abnormal_embryo_hatching4.43975278
3MP0010094_abnormal_chromosome_stability4.33492150
4MP0003111_abnormal_nucleus_morphology4.09088309
5MP0004957_abnormal_blastocyst_morpholog3.89598278
6MP0003077_abnormal_cell_cycle3.60894670
7MP0008058_abnormal_DNA_repair2.69832136
8MP0010352_gastrointestinal_tract_polyps2.64342915
9MP0009697_abnormal_copulation2.55420721
10MP0010307_abnormal_tumor_latency2.53665358
11MP0008007_abnormal_cellular_replicative2.33098308
12MP0008877_abnormal_DNA_methylation2.31126793
13* MP0000350_abnormal_cell_proliferation2.29988764
14* MP0001730_embryonic_growth_arrest2.28378021
15MP0005076_abnormal_cell_differentiation2.26264689
16MP0008932_abnormal_embryonic_tissue2.08424634
17MP0001672_abnormal_embryogenesis/_devel2.07749968
18MP0005380_embryogenesis_phenotype2.07749968
19MP0003890_abnormal_embryonic-extraembry2.01314384
20MP0002396_abnormal_hematopoietic_system1.93762207
21* MP0001697_abnormal_embryo_size1.92562575
22* MP0002084_abnormal_developmental_patter1.92299160
23MP0003123_paternal_imprinting1.89829300
24* MP0002086_abnormal_extraembryonic_tissu1.87064723
25MP0003984_embryonic_growth_retardation1.84340775
26* MP0002085_abnormal_embryonic_tissue1.81648202
27MP0002088_abnormal_embryonic_growth/wei1.80354462
28MP0003786_premature_aging1.78959711
29MP0004197_abnormal_fetal_growth/weight/1.72996645
30MP0000490_abnormal_crypts_of1.71334374
31MP0009278_abnormal_bone_marrow1.57593989
32* MP0002080_prenatal_lethality1.55281299
33MP0001545_abnormal_hematopoietic_system1.55271638
34MP0005397_hematopoietic_system_phenotyp1.55271638
35MP0003718_maternal_effect1.50016635
36MP0002653_abnormal_ependyma_morphology1.49983782
37MP0003567_abnormal_fetal_cardiomyocyte1.49337640
38MP0003943_abnormal_hepatobiliary_system1.48416301
39MP0004264_abnormal_extraembryonic_tissu1.47787787
40MP0002877_abnormal_melanocyte_morpholog1.46106267
41MP0002009_preneoplasia1.43535997
42MP0003121_genomic_imprinting1.41719636
43MP0003656_abnormal_erythrocyte_physiolo1.38466756
44MP0002019_abnormal_tumor_incidence1.38318597
45MP0003705_abnormal_hypodermis_morpholog1.36906471
46MP0001293_anophthalmia1.36449206
47MP0004808_abnormal_hematopoietic_stem1.29525332
48* MP0000313_abnormal_cell_death1.24011479
49MP0002210_abnormal_sex_determination1.23167252
50MP0010030_abnormal_orbit_morphology1.21407405
51MP0001145_abnormal_male_reproductive1.13858880
52MP0001188_hyperpigmentation1.13507528
53MP0003119_abnormal_digestive_system1.12084291
54MP0003787_abnormal_imprinting1.10833996
55MP0003763_abnormal_thymus_physiology1.08502962
56MP0009333_abnormal_splenocyte_physiolog1.06390436
57MP0010234_abnormal_vibrissa_follicle1.06282799
58MP0001929_abnormal_gametogenesis1.02091507
59MP0000703_abnormal_thymus_morphology1.01799807
60MP0000653_abnormal_sex_gland0.99168532
61MP0004185_abnormal_adipocyte_glucose0.99061485
62MP0009703_decreased_birth_body0.98791833
63MP0004147_increased_porphyrin_level0.98234472
64MP0003806_abnormal_nucleotide_metabolis0.95466761
65MP0003937_abnormal_limbs/digits/tail_de0.94832000
66MP0005075_abnormal_melanosome_morpholog0.94098842
67MP0000569_abnormal_digit_pigmentation0.92158750
68MP0010678_abnormal_skin_adnexa0.91309597
69MP0006292_abnormal_olfactory_placode0.91112110
70* MP0002398_abnormal_bone_marrow0.90518992
71MP0001119_abnormal_female_reproductive0.89569671
72MP0008995_early_reproductive_senescence0.89358930
73MP0001915_intracranial_hemorrhage0.88598723
74MP0005174_abnormal_tail_pigmentation0.88475772
75MP0001873_stomach_inflammation0.88235474
76MP0001849_ear_inflammation0.88228589
77MP0009053_abnormal_anal_canal0.85500392
78MP0000015_abnormal_ear_pigmentation0.83775370
79MP0002160_abnormal_reproductive_system0.83553706
80MP0001661_extended_life_span0.83432419
81MP0002722_abnormal_immune_system0.82176673
82MP0000432_abnormal_head_morphology0.82066243
83MP0003221_abnormal_cardiomyocyte_apopto0.82025108
84MP0000689_abnormal_spleen_morphology0.80908607
85MP0002006_tumorigenesis0.80753435
86MP0002092_abnormal_eye_morphology0.80539126
87MP0003453_abnormal_keratinocyte_physiol0.80489653
88MP0005621_abnormal_cell_physiology0.79131329
89MP0003935_abnormal_craniofacial_develop0.77148115
90MP0003566_abnormal_cell_adhesion0.76184504
91MP0003699_abnormal_female_reproductive0.75709209
92MP0002095_abnormal_skin_pigmentation0.75396329
93MP0003950_abnormal_plasma_membrane0.75317356
94MP0001286_abnormal_eye_development0.75230334
95MP0004233_abnormal_muscle_weight0.74805360
96MP0009672_abnormal_birth_weight0.74489534
97MP0001881_abnormal_mammary_gland0.73907713
98MP0000358_abnormal_cell_content/0.73175833
99MP0002925_abnormal_cardiovascular_devel0.72468111
100MP0003755_abnormal_palate_morphology0.71594131
101MP0005501_abnormal_skin_physiology0.71280687
102MP0002111_abnormal_tail_morphology0.71279352
103MP0000477_abnormal_intestine_morphology0.70162581
104MP0002166_altered_tumor_susceptibility0.70005159
105MP0009379_abnormal_foot_pigmentation0.69974098
106MP0005384_cellular_phenotype0.69648514
107* MP0002429_abnormal_blood_cell0.69258667
108MP0000428_abnormal_craniofacial_morphol0.68419372
109MP0005220_abnormal_exocrine_pancreas0.67848786
110MP0000627_abnormal_mammary_gland0.67455825
111MP0002697_abnormal_eye_size0.67108740
112MP0008961_abnormal_basal_metabolism0.66946792
113MP0003448_altered_tumor_morphology0.66694367
114MP0000371_diluted_coat_color0.66690927
115MP0000383_abnormal_hair_follicle0.66344648
116MP0003315_abnormal_perineum_morphology0.65419657
117MP0002796_impaired_skin_barrier0.64830302
118MP0003941_abnormal_skin_development0.64471540
119MP0000427_abnormal_hair_cycle0.64436568
120MP0005367_renal/urinary_system_phenotyp0.64370887
121MP0000516_abnormal_urinary_system0.64370887
122MP0001919_abnormal_reproductive_system0.61836337
123MP0003936_abnormal_reproductive_system0.61601648
124MP0005408_hypopigmentation0.61320085
125MP0001186_pigmentation_phenotype0.61124195
126MP0005389_reproductive_system_phenotype0.60438640
127MP0005023_abnormal_wound_healing0.60413195
128MP0001346_abnormal_lacrimal_gland0.60270610
129MP0002970_abnormal_white_adipose0.60035858
130MP0000733_abnormal_muscle_development0.59549428
131MP0003698_abnormal_male_reproductive0.59084281
132MP0002075_abnormal_coat/hair_pigmentati0.58693242
133MP0001216_abnormal_epidermal_layer0.58496505
134* MP0003861_abnormal_nervous_system0.58165276
135MP0008770_decreased_survivor_rate0.57802948
136MP0002405_respiratory_system_inflammati0.57051738

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.45126720
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19150817
3Volvulus (HP:0002580)4.09387349
4Birth length less than 3rd percentile (HP:0003561)4.09258297
5Facial hemangioma (HP:0000329)4.01619221
6Abnormality of the labia minora (HP:0012880)3.67668919
7Abnormality of chromosome stability (HP:0003220)3.64951628
8Ependymoma (HP:0002888)3.55504011
9Patellar aplasia (HP:0006443)3.53074358
10Aplasia/Hypoplasia of the patella (HP:0006498)3.29401343
11Impulsivity (HP:0100710)3.25122837
12Breast hypoplasia (HP:0003187)3.21977882
13Abnormality of the ileum (HP:0001549)3.21077995
14Absent radius (HP:0003974)3.18505477
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.16844301
16Meckel diverticulum (HP:0002245)3.11335121
17Abnormality of the preputium (HP:0100587)3.01399734
18Rib fusion (HP:0000902)3.00396337
19Hypochromic microcytic anemia (HP:0004840)2.98558448
20Deep philtrum (HP:0002002)2.98536215
21Medulloblastoma (HP:0002885)2.97292342
22Aplasia involving forearm bones (HP:0009822)2.96269855
23Absent forearm bone (HP:0003953)2.96269855
24Abnormality of the astrocytes (HP:0100707)2.94704864
25Astrocytoma (HP:0009592)2.94704864
26Myelodysplasia (HP:0002863)2.90246293
27Neoplasm of the oral cavity (HP:0100649)2.89108410
28Rhabdomyosarcoma (HP:0002859)2.80903230
29Abnormality of the fingertips (HP:0001211)2.80585500
30Basal cell carcinoma (HP:0002671)2.75388471
31Absent thumb (HP:0009777)2.72631754
32Ectopic kidney (HP:0000086)2.68589866
33Aplasia/hypoplasia of the humerus (HP:0006507)2.62808064
34Squamous cell carcinoma (HP:0002860)2.57915037
35Short humerus (HP:0005792)2.54542378
36Selective tooth agenesis (HP:0001592)2.51907186
37Cafe-au-lait spot (HP:0000957)2.50355062
38Prominent nose (HP:0000448)2.50354431
39Small intestinal stenosis (HP:0012848)2.49474434
40Duodenal stenosis (HP:0100867)2.49474434
41Colon cancer (HP:0003003)2.47813099
42Glioma (HP:0009733)2.44321996
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43529903
44Abnormality of DNA repair (HP:0003254)2.43384706
45Capillary hemangiomas (HP:0005306)2.37964313
46Duplicated collecting system (HP:0000081)2.37165945
47Proximal placement of thumb (HP:0009623)2.35056832
48Curly hair (HP:0002212)2.32929813
49Deviation of the thumb (HP:0009603)2.32770367
50Pallor (HP:0000980)2.31126007
51Shawl scrotum (HP:0000049)2.29959736
52Septate vagina (HP:0001153)2.28042281
53Increased nuchal translucency (HP:0010880)2.27430307
54Ankyloglossia (HP:0010296)2.25740807
55Acute myeloid leukemia (HP:0004808)2.25166106
56Abnormality of the carotid arteries (HP:0005344)2.24662737
57Supernumerary spleens (HP:0009799)2.21869647
58Agnosia (HP:0010524)2.19663600
59Progressive external ophthalmoplegia (HP:0000590)2.18915580
60Neoplasm of striated muscle (HP:0009728)2.17280111
61Short thumb (HP:0009778)2.16006626
62Poikiloderma (HP:0001029)2.14517699
63Carpal bone hypoplasia (HP:0001498)2.13059093
64Biliary tract neoplasm (HP:0100574)2.11422657
6511 pairs of ribs (HP:0000878)2.10645516
66Sloping forehead (HP:0000340)2.10059015
67Nephroblastoma (Wilms tumor) (HP:0002667)2.09135463
68Heterotopia (HP:0002282)2.08244456
69Cystic hygroma (HP:0000476)2.08061022
70Abnormality of cells of the erythroid lineage (HP:0012130)2.07079024
71Papillary thyroid carcinoma (HP:0002895)2.06915775
72Microvesicular hepatic steatosis (HP:0001414)2.06232748
73Clubbing of toes (HP:0100760)2.05116992
74Abnormality of the duodenum (HP:0002246)2.03810786
75Short middle phalanx of the 5th finger (HP:0004220)2.03528776
76Bone marrow hypocellularity (HP:0005528)2.02956945
77Abnormality of the renal collecting system (HP:0004742)2.02469292
78Low anterior hairline (HP:0000294)2.01861047
79Embryonal neoplasm (HP:0002898)2.01695681
80Male infertility (HP:0003251)2.01637846
81Hypochromic anemia (HP:0001931)2.01313787
82Intestinal fistula (HP:0100819)2.01226972
83Atresia of the external auditory canal (HP:0000413)1.99781988
84Macroorchidism (HP:0000053)1.99706104
85Choanal atresia (HP:0000453)1.99211492
86Gastrointestinal carcinoma (HP:0002672)1.98790899
87Malignant gastrointestinal tract tumors (HP:0006749)1.98790899
88Abnormality of the anterior horn cell (HP:0006802)1.98692111
89Degeneration of anterior horn cells (HP:0002398)1.98692111
90Transitional cell carcinoma of the bladder (HP:0006740)1.98675449
91Premature graying of hair (HP:0002216)1.98255908
92Sandal gap (HP:0001852)1.96249929
93Rectal fistula (HP:0100590)1.95395411
94Rectovaginal fistula (HP:0000143)1.95395411
95Amaurosis fugax (HP:0100576)1.94486597
96Duplication of thumb phalanx (HP:0009942)1.94367431
97Abnormal lung lobation (HP:0002101)1.93062799
98Abnormality of chromosome segregation (HP:0002916)1.91702322
99Tracheoesophageal fistula (HP:0002575)1.91515732
100Triphalangeal thumb (HP:0001199)1.90773634
101Sparse lateral eyebrow (HP:0005338)1.90715900
102Embryonal renal neoplasm (HP:0011794)1.90680968
103Abnormal foot bone ossification (HP:0010675)1.90583539
104Relative macrocephaly (HP:0004482)1.89923708
105Urethral obstruction (HP:0000796)1.89468338
106Abnormal number of incisors (HP:0011064)1.89385985
107Abnormality of lateral ventricle (HP:0030047)1.89147797
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.86910805
109Missing ribs (HP:0000921)1.86865231
110Oral leukoplakia (HP:0002745)1.86366799
111Acute lymphatic leukemia (HP:0006721)1.85964160
112Bladder carcinoma (HP:0002862)1.85229195
113Bladder neoplasm (HP:0009725)1.85229195
114Overlapping toe (HP:0001845)1.84434085
115Neoplasm of the pancreas (HP:0002894)1.83175011
116B lymphocytopenia (HP:0010976)1.82689723
117Macrocytic anemia (HP:0001972)1.82625934
118Acanthocytosis (HP:0001927)1.81502940
119Oligodactyly (HP:0012165)1.79899895
120Lip pit (HP:0100267)1.75849730
121Long eyelashes (HP:0000527)1.75104611
122Truncal obesity (HP:0001956)1.74597058
123Broad alveolar ridges (HP:0000187)1.74482561
124Reticulocytopenia (HP:0001896)1.74343908
125Recurrent viral infections (HP:0004429)1.74320373
126Abnormality of oral frenula (HP:0000190)1.72448819
127Termporal pattern (HP:0011008)1.72412893
128Insidious onset (HP:0003587)1.72412893
129Delayed puberty (HP:0000823)1.71553091
130Leiomyosarcoma (HP:0100243)1.71347983
131Uterine leiomyosarcoma (HP:0002891)1.71347983
132Radioulnar synostosis (HP:0002974)1.71299667
133Obsessive-compulsive behavior (HP:0000722)1.69921558
134High pitched voice (HP:0001620)1.68755579
135Multiple enchondromatosis (HP:0005701)1.68344650
136Homocystinuria (HP:0002156)1.67848591
137Abnormality of homocysteine metabolism (HP:0010919)1.67848591
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67054654
139Neoplasm of the colon (HP:0100273)1.66823666
140Arteriovenous malformation (HP:0100026)1.66582825
141IgA deficiency (HP:0002720)1.66461565
142Lymphoma (HP:0002665)1.66280313
143Horseshoe kidney (HP:0000085)1.65039861
144Spinal muscular atrophy (HP:0007269)1.64702557
145Deep palmar crease (HP:0006191)1.63721836
146Cortical dysplasia (HP:0002539)1.61644615
147Panhypogammaglobulinemia (HP:0003139)1.59722909
148Thickened helices (HP:0000391)1.59598628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.41194086
2CDK124.08352146
3NEK23.33663913
4WEE13.17936470
5LATS12.75940973
6TTK2.61001336
7TAF12.32366476
8SRPK12.20228150
9CHEK22.15105105
10BUB12.10169643
11MAP3K62.07725041
12PLK12.04633156
13LATS21.94786058
14NEK11.91503429
15CDK71.89897417
16STK31.89693932
17PLK41.89211564
18ACVR1B1.87428652
19BRSK21.82483905
20EEF2K1.76638601
21CDK41.74390525
22PBK1.71834063
23ATR1.67550359
24CDK61.66126114
25AURKB1.61017407
26ICK1.56463280
27CHEK11.55942347
28STK38L1.54934455
29DYRK31.53327419
30RPS6KB21.52381324
31MKNK21.51136140
32PLK31.44575049
33MST41.44360354
34EIF2AK11.40191148
35STK101.39753618
36MAP3K141.39615677
37PIM11.36265765
38SMG11.33494106
39TYRO31.30887649
40ATM1.30526488
41EPHA21.29038273
42MELK1.26847519
43BRD41.26260683
44MKNK11.25341387
45CAMK1G1.24382865
46MAP3K101.24187569
47EIF2AK21.21525513
48ALK1.20189706
49MAP3K81.16487399
50CDK21.12559854
51STK41.09143485
52RPS6KA41.03390031
53PKN20.98708469
54TSSK60.98521061
55CAMK1D0.94971536
56AKT30.93156712
57FGFR30.92095367
58DDR20.92093654
59SCYL20.90514583
60BRSK10.90063310
61MST1R0.89223550
62MTOR0.87559703
63PRPF4B0.86202706
64WNK10.83691654
65AURKA0.83669827
66BMPR20.82099914
67CDK10.81703552
68CDK30.81659400
69PASK0.80899266
70CLK10.79710851
71CDK90.78036496
72BMX0.69573115
73BRAF0.67666240
74EIF2AK30.66785810
75VRK10.66432609
76STK390.65837522
77CCNB10.65656421
78KSR10.65472594
79MAP3K20.64851944
80FGR0.64184275
81NEK90.64014365
82TRPM70.63587606
83CSK0.63182453
84RAF10.62954011
85CDK80.61592694
86JAK30.61473233
87PDGFRA0.61067665
88TEC0.58199972
89KSR20.57760651
90WNK40.54492289
91MAP3K110.54359481
92NME20.53871956
93MAP4K10.53776242
94MAPK140.53197211
95CSNK1D0.52964065
96YES10.52212387
97TGFBR10.51395970
98PNCK0.51094176
99MATK0.50890118
100TAOK10.50850340
101CSNK2A20.50673281
102NLK0.47575766
103MAP3K130.46816572
104CSNK1E0.46637517
105MARK30.46255894
106PRKDC0.46158118
107FGFR10.45921599
108MAPK110.45803560
109NUAK10.44969525
110PRKD20.44589651
111CSNK2A10.44311946
112STK240.42221172
113ERBB40.41627284
114PAK40.40770219
115PRKAA10.40588849
116IRAK30.40473364
117RPS6KB10.37637052
118TRIB30.37422031
119MAPK100.37363511
120MAPK10.37265755
121TESK20.36457259
122ERBB30.36161428
123FLT30.34851235
124GSK3B0.34825762
125CSNK1G10.34030024
126ZAK0.33983205
127PRKCI0.33945797
128MAP3K50.33336682
129AKT10.33264087
130RPS6KA10.33020220
131TLK10.32738456
132VRK20.29942156
133MAP2K30.26310533

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06080981
2Mismatch repair_Homo sapiens_hsa034303.96009998
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55094067
4RNA transport_Homo sapiens_hsa030133.30746305
5Cell cycle_Homo sapiens_hsa041103.27062074
6Base excision repair_Homo sapiens_hsa034102.90335331
7Spliceosome_Homo sapiens_hsa030402.80281541
8Homologous recombination_Homo sapiens_hsa034402.77928759
9Fanconi anemia pathway_Homo sapiens_hsa034602.77773320
10Nucleotide excision repair_Homo sapiens_hsa034202.56938675
11mRNA surveillance pathway_Homo sapiens_hsa030152.45707277
12p53 signaling pathway_Homo sapiens_hsa041152.13615162
13RNA polymerase_Homo sapiens_hsa030202.09301807
14One carbon pool by folate_Homo sapiens_hsa006702.09152393
15Basal transcription factors_Homo sapiens_hsa030222.01697245
16RNA degradation_Homo sapiens_hsa030181.97989655
17Non-homologous end-joining_Homo sapiens_hsa034501.96601745
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54683242
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50693889
20MicroRNAs in cancer_Homo sapiens_hsa052061.40847513
21mTOR signaling pathway_Homo sapiens_hsa041501.36834026
22Pyrimidine metabolism_Homo sapiens_hsa002401.35830854
23Oocyte meiosis_Homo sapiens_hsa041141.29697705
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24530864
25Herpes simplex infection_Homo sapiens_hsa051681.22912637
26Viral carcinogenesis_Homo sapiens_hsa052031.21235990
27Vitamin B6 metabolism_Homo sapiens_hsa007501.20609409
28TGF-beta signaling pathway_Homo sapiens_hsa043501.15122584
29Ribosome_Homo sapiens_hsa030101.13528037
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10078073
31Epstein-Barr virus infection_Homo sapiens_hsa051691.09781993
32Adherens junction_Homo sapiens_hsa045201.06126503
33Protein export_Homo sapiens_hsa030601.05972455
34Colorectal cancer_Homo sapiens_hsa052101.05544341
35Small cell lung cancer_Homo sapiens_hsa052221.05128958
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03548903
37Hippo signaling pathway_Homo sapiens_hsa043901.01653614
38Thyroid cancer_Homo sapiens_hsa052160.98642355
39HTLV-I infection_Homo sapiens_hsa051660.97430165
40Notch signaling pathway_Homo sapiens_hsa043300.93263573
41Chronic myeloid leukemia_Homo sapiens_hsa052200.92441754
42Antigen processing and presentation_Homo sapiens_hsa046120.92230787
43Primary immunodeficiency_Homo sapiens_hsa053400.85508890
44Systemic lupus erythematosus_Homo sapiens_hsa053220.84135093
45Lysine degradation_Homo sapiens_hsa003100.81454717
46Pancreatic cancer_Homo sapiens_hsa052120.77427612
47Proteasome_Homo sapiens_hsa030500.76960510
48Hepatitis B_Homo sapiens_hsa051610.76588904
49Prostate cancer_Homo sapiens_hsa052150.75392482
50Glioma_Homo sapiens_hsa052140.74249517
51Viral myocarditis_Homo sapiens_hsa054160.67963663
52Fatty acid biosynthesis_Homo sapiens_hsa000610.67683352
53Endometrial cancer_Homo sapiens_hsa052130.66826630
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65285288
55Circadian rhythm_Homo sapiens_hsa047100.64439700
56Pentose phosphate pathway_Homo sapiens_hsa000300.64067642
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63657523
58Biosynthesis of amino acids_Homo sapiens_hsa012300.62126150
59Non-small cell lung cancer_Homo sapiens_hsa052230.60976526
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59564826
61Purine metabolism_Homo sapiens_hsa002300.59423245
62FoxO signaling pathway_Homo sapiens_hsa040680.59289358
63Selenocompound metabolism_Homo sapiens_hsa004500.58540306
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58512755
65Acute myeloid leukemia_Homo sapiens_hsa052210.58277920
66Bladder cancer_Homo sapiens_hsa052190.58238115
67Measles_Homo sapiens_hsa051620.57477415
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.57123972
69Shigellosis_Homo sapiens_hsa051310.56854988
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56230097
71ErbB signaling pathway_Homo sapiens_hsa040120.55571112
72Apoptosis_Homo sapiens_hsa042100.53650217
73Basal cell carcinoma_Homo sapiens_hsa052170.52383805
74Dorso-ventral axis formation_Homo sapiens_hsa043200.51284190
75N-Glycan biosynthesis_Homo sapiens_hsa005100.50432115
76Pathways in cancer_Homo sapiens_hsa052000.49004136
77Hedgehog signaling pathway_Homo sapiens_hsa043400.48505079
78Wnt signaling pathway_Homo sapiens_hsa043100.47318880
79Inositol phosphate metabolism_Homo sapiens_hsa005620.45568152
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.45235428
81Tight junction_Homo sapiens_hsa045300.43485544
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43001599
83Prolactin signaling pathway_Homo sapiens_hsa049170.41486937
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41380867
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41279799
86B cell receptor signaling pathway_Homo sapiens_hsa046620.40654466
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40576865
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.40539752
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40439218
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39597523
91AMPK signaling pathway_Homo sapiens_hsa041520.39080810
92Renal cell carcinoma_Homo sapiens_hsa052110.39057519
93Proteoglycans in cancer_Homo sapiens_hsa052050.38352748
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.38329800
95Influenza A_Homo sapiens_hsa051640.38303517
96Hepatitis C_Homo sapiens_hsa051600.38269027
97VEGF signaling pathway_Homo sapiens_hsa043700.37866675
98HIF-1 signaling pathway_Homo sapiens_hsa040660.36925523
99Legionellosis_Homo sapiens_hsa051340.35422682
100Choline metabolism in cancer_Homo sapiens_hsa052310.35374957
101Propanoate metabolism_Homo sapiens_hsa006400.35128128
102T cell receptor signaling pathway_Homo sapiens_hsa046600.34406042
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.34229516
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31430500
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30155863
106Alcoholism_Homo sapiens_hsa050340.29389128
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29231449
108Melanoma_Homo sapiens_hsa052180.28759215
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27137425
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.26752779
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.25822660
112Platelet activation_Homo sapiens_hsa046110.24998997
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24688543
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24574044
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23971975
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23939144
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.21021603
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20584269
119Insulin signaling pathway_Homo sapiens_hsa049100.19318842
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18061244

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