SV2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66144879
2synaptic vesicle maturation (GO:0016188)5.30863643
3vocalization behavior (GO:0071625)5.23567078
4synaptic vesicle exocytosis (GO:0016079)5.21984077
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20373907
6neuron cell-cell adhesion (GO:0007158)5.12747112
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.07340134
8locomotory exploration behavior (GO:0035641)5.00973793
9glutamate secretion (GO:0014047)4.75555775
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72601462
11regulation of synaptic vesicle exocytosis (GO:2000300)4.68392608
12neuronal action potential propagation (GO:0019227)4.61966834
13protein localization to synapse (GO:0035418)4.49273658
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.48498491
15regulation of glutamate receptor signaling pathway (GO:1900449)4.35309417
16neurotransmitter secretion (GO:0007269)4.28656135
17gamma-aminobutyric acid transport (GO:0015812)4.23026427
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.18401308
19regulation of synaptic vesicle transport (GO:1902803)4.10629813
20glutamate receptor signaling pathway (GO:0007215)4.06872754
21exploration behavior (GO:0035640)4.04913442
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.04764622
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01468864
24positive regulation of dendritic spine morphogenesis (GO:0061003)3.99465426
25layer formation in cerebral cortex (GO:0021819)3.97733949
26regulation of neuronal synaptic plasticity (GO:0048168)3.97275769
27synaptic transmission, glutamatergic (GO:0035249)3.92278125
28neuron-neuron synaptic transmission (GO:0007270)3.91241683
29neuron recognition (GO:0008038)3.88529022
30transmission of nerve impulse (GO:0019226)3.87026696
31dendritic spine morphogenesis (GO:0060997)3.86275171
32potassium ion homeostasis (GO:0055075)3.84279681
33cell migration in hindbrain (GO:0021535)3.81980387
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.79584410
35establishment of mitochondrion localization (GO:0051654)3.77313598
36cell communication by electrical coupling (GO:0010644)3.76076011
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72914089
38amino acid import (GO:0043090)3.68267708
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.65214344
40long-term memory (GO:0007616)3.63913478
41* neurotransmitter transport (GO:0006836)3.63870909
42central nervous system myelination (GO:0022010)3.63381750
43axon ensheathment in central nervous system (GO:0032291)3.63381750
44cellular potassium ion homeostasis (GO:0030007)3.62284500
45regulation of synapse maturation (GO:0090128)3.62088494
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.61184355
47presynaptic membrane assembly (GO:0097105)3.57812312
48positive regulation of membrane potential (GO:0045838)3.56223261
49pyrimidine nucleobase catabolic process (GO:0006208)3.55566720
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53524094
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52584961
52presynaptic membrane organization (GO:0097090)3.51976609
53regulation of synapse structural plasticity (GO:0051823)3.51898258
54neurotransmitter-gated ion channel clustering (GO:0072578)3.48246914
55mating behavior (GO:0007617)3.47851428
56positive regulation of neurotransmitter transport (GO:0051590)3.46330405
57regulation of neurotransmitter levels (GO:0001505)3.42728985
58axonal fasciculation (GO:0007413)3.41507177
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40928723
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40083397
61neuromuscular process controlling posture (GO:0050884)3.39904224
62regulation of postsynaptic membrane potential (GO:0060078)3.39670847
63potassium ion import (GO:0010107)3.39660861
64neuromuscular synaptic transmission (GO:0007274)3.34934071
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.29216065
66mitochondrion transport along microtubule (GO:0047497)3.29216065
67glycine transport (GO:0015816)3.26378389
68regulation of vesicle fusion (GO:0031338)3.26042774
69proline transport (GO:0015824)3.25270121
70neuronal ion channel clustering (GO:0045161)3.24645024
71cerebellar Purkinje cell layer development (GO:0021680)3.24264622
72negative regulation of neurotransmitter transport (GO:0051589)3.24065696
73adult walking behavior (GO:0007628)3.23740734
74negative regulation of dendrite morphogenesis (GO:0050774)3.23157144
75synaptic vesicle endocytosis (GO:0048488)3.22895200
76mechanosensory behavior (GO:0007638)3.22594041
77regulation of neurotransmitter secretion (GO:0046928)3.21510584
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19671801
79postsynaptic membrane organization (GO:0001941)3.19104083
80cellular sodium ion homeostasis (GO:0006883)3.18391681
81cerebellar Purkinje cell differentiation (GO:0021702)3.18173977
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18119536
83long-term synaptic potentiation (GO:0060291)3.17503095
84cerebellar granule cell differentiation (GO:0021707)3.16948181
85regulation of synaptic plasticity (GO:0048167)3.16814702
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.16794557
87regulation of dendritic spine morphogenesis (GO:0061001)3.15230652
88membrane hyperpolarization (GO:0060081)3.14518647
89positive regulation of neurotransmitter secretion (GO:0001956)3.14259525
90cell differentiation in hindbrain (GO:0021533)3.13193335
91positive regulation of synapse maturation (GO:0090129)3.11423098
92sodium ion export (GO:0071436)3.10749565
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09902134
94auditory behavior (GO:0031223)3.09889404
95synaptic vesicle transport (GO:0048489)3.09704602
96establishment of synaptic vesicle localization (GO:0097480)3.09704602
97synapse assembly (GO:0007416)3.08375762
98prepulse inhibition (GO:0060134)3.05663670
99dendrite morphogenesis (GO:0048813)3.04873280
100L-amino acid import (GO:0043092)3.03849560
101activation of protein kinase A activity (GO:0034199)3.03456141
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02641547
103regulation of neurotransmitter transport (GO:0051588)3.02369785
104neuromuscular process controlling balance (GO:0050885)3.02060010
105membrane depolarization (GO:0051899)2.99546878
106behavioral response to cocaine (GO:0048148)2.97060991
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95968483
108response to auditory stimulus (GO:0010996)2.95284883
109learning (GO:0007612)2.95060930
110response to histamine (GO:0034776)2.91722357
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88925599
112synapse organization (GO:0050808)2.88539389
113startle response (GO:0001964)2.88227541
114regulation of synaptic transmission, GABAergic (GO:0032228)2.87699748
115regulation of glutamate secretion (GO:0014048)2.87301894
116positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86812782
117synaptic transmission (GO:0007268)2.86616213
118positive regulation of synapse assembly (GO:0051965)2.86244841
119positive regulation of dendritic spine development (GO:0060999)2.85331922
120regulation of voltage-gated calcium channel activity (GO:1901385)2.83933118
121intraspecies interaction between organisms (GO:0051703)2.82889404
122social behavior (GO:0035176)2.82889404
123membrane depolarization during action potential (GO:0086010)2.81866960
124regulation of dendritic spine development (GO:0060998)2.81490693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89454009
2GBX2_23144817_ChIP-Seq_PC3_Human3.59341836
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13347216
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06791564
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03821206
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65984442
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65984442
8REST_21632747_ChIP-Seq_MESCs_Mouse2.62488564
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56331685
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55775466
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52457803
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51151206
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.50209458
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49297372
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48962719
16DROSHA_22980978_ChIP-Seq_HELA_Human2.37904336
17RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.33131241
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.31409921
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.27338173
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27209066
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.24856503
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.15038132
23TAF15_26573619_Chip-Seq_HEK293_Human2.14380503
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11129207
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01571407
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01279731
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97711883
28AR_21572438_ChIP-Seq_LNCaP_Human1.93097735
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90301061
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87027226
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86837124
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80196522
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78072896
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70540617
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62244143
36SMAD4_21799915_ChIP-Seq_A2780_Human1.60142764
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59551593
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52057288
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.49759765
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49329061
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47046677
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45449901
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.45372277
44ZNF274_21170338_ChIP-Seq_K562_Hela1.44060360
45KDM2B_26808549_Chip-Seq_K562_Human1.43202216
46P300_19829295_ChIP-Seq_ESCs_Human1.41169830
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38281655
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.37999290
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37837738
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37497842
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36874220
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.36721642
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33308480
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30800960
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30757750
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28881978
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28213535
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.27724571
59IGF1R_20145208_ChIP-Seq_DFB_Human1.26348363
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25474728
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25355100
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.25250733
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24920944
64STAT3_23295773_ChIP-Seq_U87_Human1.23727476
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.23675003
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21099135
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20058793
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18890772
69CTCF_27219007_Chip-Seq_Bcells_Human1.18676806
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18430198
71AR_25329375_ChIP-Seq_VCAP_Human1.17266024
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15698941
73RNF2_27304074_Chip-Seq_NSC_Mouse1.15378411
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.14970841
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14293001
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13716886
77ER_23166858_ChIP-Seq_MCF-7_Human1.09869756
78TCF4_23295773_ChIP-Seq_U87_Human1.09859295
79* AR_19668381_ChIP-Seq_PC3_Human1.09493232
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09234304
81FUS_26573619_Chip-Seq_HEK293_Human1.08292312
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07889989
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06835071
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06137989
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05168077
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.05120799
87VDR_22108803_ChIP-Seq_LS180_Human1.04989926
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.04962106
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04417568
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03710481
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.03006685
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01258836
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.01210454
94RUNX2_22187159_ChIP-Seq_PCA_Human1.00852414
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99448375
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98955607
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.97412046
98AHR_22903824_ChIP-Seq_MCF-7_Human0.96893032
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96664996
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95979152
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95978288
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94661694
103* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93232629
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92579273
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91990646
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.91305074
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90680319
108JUN_21703547_ChIP-Seq_K562_Human0.88420837
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88332971
110SOX9_26525672_Chip-Seq_HEART_Mouse0.88096444
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87944816
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.87900134
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87740008
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.87143167
115TP53_16413492_ChIP-PET_HCT116_Human0.85647200
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.85320022
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84345443
118OCT4_19829295_ChIP-Seq_ESCs_Human0.84040092
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83852243
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82092142
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82092142
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81288386
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.81157697
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81063250
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79609786
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78482520
127* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.77855306
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76243605
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.72267765
130KLF4_19829295_ChIP-Seq_ESCs_Human0.71640846
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71271202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56174237
2MP0003880_abnormal_central_pattern5.15558426
3* MP0003635_abnormal_synaptic_transmissio3.93993986
4MP0004270_analgesia3.55649201
5MP0009745_abnormal_behavioral_response3.37195711
6MP0009046_muscle_twitch3.32411012
7* MP0002064_seizures3.24030603
8MP0002063_abnormal_learning/memory/cond3.06862302
9MP0005423_abnormal_somatic_nervous3.03581197
10MP0002272_abnormal_nervous_system2.83254292
11MP0002572_abnormal_emotion/affect_behav2.73951335
12MP0001486_abnormal_startle_reflex2.72540374
13MP0001968_abnormal_touch/_nociception2.68545296
14MP0002734_abnormal_mechanical_nocicepti2.60469384
15MP0002822_catalepsy2.48702390
16MP0001501_abnormal_sleep_pattern2.35653199
17MP0001440_abnormal_grooming_behavior2.24824797
18MP0003329_amyloid_beta_deposits2.17182944
19MP0002067_abnormal_sensory_capabilities2.03945388
20MP0002736_abnormal_nociception_after2.03124750
21MP0002733_abnormal_thermal_nociception2.01649363
22MP0002735_abnormal_chemical_nociception1.97327814
23MP0001529_abnormal_vocalization1.96832568
24MP0001970_abnormal_pain_threshold1.96557049
25MP0006276_abnormal_autonomic_nervous1.95270654
26MP0000778_abnormal_nervous_system1.88650527
27MP0001905_abnormal_dopamine_level1.84095755
28MP0004924_abnormal_behavior1.83841647
29MP0005386_behavior/neurological_phenoty1.83841647
30MP0003123_paternal_imprinting1.80045004
31MP0002184_abnormal_innervation1.77277409
32MP0004142_abnormal_muscle_tone1.75007972
33* MP0008569_lethality_at_weaning1.74111457
34MP0002557_abnormal_social/conspecific_i1.71082947
35MP0004885_abnormal_endolymph1.70761782
36MP0000920_abnormal_myelination1.69713710
37MP0009780_abnormal_chondrocyte_physiolo1.65246400
38MP0000955_abnormal_spinal_cord1.59235517
39MP0004811_abnormal_neuron_physiology1.52778966
40MP0002066_abnormal_motor_capabilities/c1.51146246
41MP0002882_abnormal_neuron_morphology1.50534989
42MP0005646_abnormal_pituitary_gland1.48539758
43MP0002909_abnormal_adrenal_gland1.47283191
44MP0005645_abnormal_hypothalamus_physiol1.44880972
45MP0003122_maternal_imprinting1.44487525
46MP0001984_abnormal_olfaction1.44455949
47MP0005551_abnormal_eye_electrophysiolog1.39717137
48MP0004742_abnormal_vestibular_system1.36957091
49MP0003121_genomic_imprinting1.33707059
50MP0001502_abnormal_circadian_rhythm1.32270392
51MP0003633_abnormal_nervous_system1.31039410
52MP0002229_neurodegeneration1.30821793
53MP0003690_abnormal_glial_cell1.28598636
54MP0003879_abnormal_hair_cell1.24550512
55MP0003631_nervous_system_phenotype1.22321635
56MP0004858_abnormal_nervous_system1.22092925
57MP0008877_abnormal_DNA_methylation1.21730275
58MP0003787_abnormal_imprinting1.18965142
59MP0003634_abnormal_glial_cell1.18065141
60MP0004145_abnormal_muscle_electrophysio1.14074149
61MP0003632_abnormal_nervous_system1.10414869
62MP0002152_abnormal_brain_morphology1.10290855
63MP0001188_hyperpigmentation1.02187193
64MP0000013_abnormal_adipose_tissue1.00157905
65MP0000604_amyloidosis0.98071413
66MP0005409_darkened_coat_color0.96738018
67MP0002837_dystrophic_cardiac_calcinosis0.95980879
68MP0008872_abnormal_physiological_respon0.95611960
69MP0000751_myopathy0.94685721
70MP0001963_abnormal_hearing_physiology0.94259606
71MP0002752_abnormal_somatic_nervous0.92362908
72MP0001177_atelectasis0.92300985
73MP0002069_abnormal_eating/drinking_beha0.90761818
74MP0010386_abnormal_urinary_bladder0.89471755
75MP0001485_abnormal_pinna_reflex0.88351956
76MP0006072_abnormal_retinal_apoptosis0.87929324
77MP0004043_abnormal_pH_regulation0.85460400
78MP0002090_abnormal_vision0.84474461
79MP0008874_decreased_physiological_sensi0.83037925
80MP0005535_abnormal_body_temperature0.82864948
81MP0003283_abnormal_digestive_organ0.82238795
82MP0000631_abnormal_neuroendocrine_gland0.82175333
83MP0001986_abnormal_taste_sensitivity0.80580237
84MP0001348_abnormal_lacrimal_gland0.80153063
85MP0004085_abnormal_heartbeat0.79960499
86MP0001346_abnormal_lacrimal_gland0.73095630
87MP0005499_abnormal_olfactory_system0.71561814
88MP0005394_taste/olfaction_phenotype0.71561814
89MP0002638_abnormal_pupillary_reflex0.70967367
90MP0001299_abnormal_eye_distance/0.69991066
91MP0004147_increased_porphyrin_level0.69266884
92MP0003137_abnormal_impulse_conducting0.68377814
93MP0003938_abnormal_ear_development0.67958285
94MP0005253_abnormal_eye_physiology0.67339482
95MP0000579_abnormal_nail_morphology0.65569158
96MP0001664_abnormal_digestion0.64636174
97MP0005623_abnormal_meninges_morphology0.63480142
98* MP0002082_postnatal_lethality0.62811303
99MP0005171_absent_coat_pigmentation0.62516378
100MP0005410_abnormal_fertilization0.62003480
101* MP0010768_mortality/aging0.61116235
102MP0000747_muscle_weakness0.61038050
103MP0001943_abnormal_respiration0.60568638
104MP0004133_heterotaxia0.60220347
105MP0004215_abnormal_myocardial_fiber0.58353193
106MP0006292_abnormal_olfactory_placode0.57832775
107MP0000566_synostosis0.57470033
108MP0002081_perinatal_lethality0.55741864
109MP0000026_abnormal_inner_ear0.54429319
110MP0002876_abnormal_thyroid_physiology0.53739553
111MP0003861_abnormal_nervous_system0.52272856
112MP0004484_altered_response_of0.52100905
113* MP0010769_abnormal_survival0.51686649
114MP0005195_abnormal_posterior_eye0.51150468
115* MP0003956_abnormal_body_size0.50734997
116* MP0010770_preweaning_lethality0.50699133
117MP0000569_abnormal_digit_pigmentation0.48231786
118MP0003119_abnormal_digestive_system0.47476007

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.06990123
2Myokymia (HP:0002411)5.92318773
3Focal seizures (HP:0007359)5.31700411
4Visual hallucinations (HP:0002367)5.10849105
5Atonic seizures (HP:0010819)4.67532081
6Epileptic encephalopathy (HP:0200134)4.47752598
7Supranuclear gaze palsy (HP:0000605)4.14646351
8Progressive cerebellar ataxia (HP:0002073)4.13201515
9Neurofibrillary tangles (HP:0002185)4.06638801
10Absence seizures (HP:0002121)3.97668579
11Febrile seizures (HP:0002373)3.93196580
12Dialeptic seizures (HP:0011146)3.71544383
13Generalized tonic-clonic seizures (HP:0002069)3.68386208
14Cerebral inclusion bodies (HP:0100314)3.66002872
15Action tremor (HP:0002345)3.61457669
16Ankle clonus (HP:0011448)3.53661959
17Broad-based gait (HP:0002136)3.46017394
18Dysmetria (HP:0001310)3.42298356
19Abnormality of the corticospinal tract (HP:0002492)3.35846503
20Dysdiadochokinesis (HP:0002075)3.21423400
21Limb dystonia (HP:0002451)3.21290992
22Cerebral hypomyelination (HP:0006808)3.14621701
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.13719176
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.13719176
25Gaze-evoked nystagmus (HP:0000640)3.13375889
26Spastic gait (HP:0002064)3.13345876
27Progressive inability to walk (HP:0002505)3.04408237
28Mutism (HP:0002300)3.03620309
29Hyperventilation (HP:0002883)2.98177145
30Truncal ataxia (HP:0002078)2.97029941
31Anxiety (HP:0000739)2.94781556
32Scanning speech (HP:0002168)2.93852804
33Intention tremor (HP:0002080)2.91060666
34Depression (HP:0000716)2.89920162
35Abnormal eating behavior (HP:0100738)2.88181310
36Poor eye contact (HP:0000817)2.87361412
37Annular pancreas (HP:0001734)2.87105545
38Impaired vibration sensation in the lower limbs (HP:0002166)2.84972960
39Pheochromocytoma (HP:0002666)2.84140421
40Urinary bladder sphincter dysfunction (HP:0002839)2.81947339
41Insidious onset (HP:0003587)2.76798350
42Termporal pattern (HP:0011008)2.76798350
43Postural instability (HP:0002172)2.70773765
44Sleep apnea (HP:0010535)2.69122426
45Impaired social interactions (HP:0000735)2.68461384
46Abnormal social behavior (HP:0012433)2.68461384
47Abnormality of the lower motor neuron (HP:0002366)2.67403751
48Hemiparesis (HP:0001269)2.64065293
49Obstructive sleep apnea (HP:0002870)2.61984731
50Urinary urgency (HP:0000012)2.60633707
51Abnormality of binocular vision (HP:0011514)2.58686509
52Diplopia (HP:0000651)2.58686509
53Drooling (HP:0002307)2.58599900
54Excessive salivation (HP:0003781)2.58599900
55Tetraplegia (HP:0002445)2.53683496
56Peripheral hypomyelination (HP:0007182)2.50290333
57Papilledema (HP:0001085)2.49868617
58Amblyopia (HP:0000646)2.49093931
59Neuroendocrine neoplasm (HP:0100634)2.47578317
60Polyphagia (HP:0002591)2.38567348
61Insomnia (HP:0100785)2.37841600
62Generalized myoclonic seizures (HP:0002123)2.36076613
63Lower limb muscle weakness (HP:0007340)2.35422709
64Epileptiform EEG discharges (HP:0011182)2.33438757
65EEG with generalized epileptiform discharges (HP:0011198)2.29581345
66Genetic anticipation (HP:0003743)2.29204947
67Absent speech (HP:0001344)2.29178929
68Bradykinesia (HP:0002067)2.27645486
69Retinal dysplasia (HP:0007973)2.22402679
70Akinesia (HP:0002304)2.20898614
71Neuronal loss in central nervous system (HP:0002529)2.20505199
72Torticollis (HP:0000473)2.19258447
73Megalencephaly (HP:0001355)2.18162642
74Hypsarrhythmia (HP:0002521)2.17890859
75Apathy (HP:0000741)2.17680401
76CNS hypomyelination (HP:0003429)2.15514102
77Spastic tetraparesis (HP:0001285)2.13713171
78Hemiplegia (HP:0002301)2.10915449
79Fetal akinesia sequence (HP:0001989)2.10496224
80Agitation (HP:0000713)2.09447742
81Inability to walk (HP:0002540)2.08490949
82Impaired smooth pursuit (HP:0007772)2.08446837
83Psychosis (HP:0000709)2.07053984
84Focal dystonia (HP:0004373)2.02469831
85Clonus (HP:0002169)2.01724639
86Turricephaly (HP:0000262)2.00538292
87Diminished motivation (HP:0000745)1.99423775
88Status epilepticus (HP:0002133)1.97776655
89Morphological abnormality of the pyramidal tract (HP:0002062)1.97418109
90Gait imbalance (HP:0002141)1.97024193
91Blue irides (HP:0000635)1.95327091
92Delusions (HP:0000746)1.95129501
93Gait ataxia (HP:0002066)1.94670926
94Amyotrophic lateral sclerosis (HP:0007354)1.94634986
95Rigidity (HP:0002063)1.93600771
96Spastic tetraplegia (HP:0002510)1.93577580
97Stereotypic behavior (HP:0000733)1.92747648
98Abnormality of ocular smooth pursuit (HP:0000617)1.89147941
99Aplasia involving bones of the upper limbs (HP:0009823)1.87275268
100Aplasia of the phalanges of the hand (HP:0009802)1.87275268
101Aplasia involving bones of the extremities (HP:0009825)1.87275268
102Incomplete penetrance (HP:0003829)1.86845364
103Abnormality of saccadic eye movements (HP:0000570)1.86292925
104Specific learning disability (HP:0001328)1.85283038
105Choreoathetosis (HP:0001266)1.84746732
106Craniofacial dystonia (HP:0012179)1.84084792
107Impaired vibratory sensation (HP:0002495)1.80440450
108Rapidly progressive (HP:0003678)1.79360633
109Onion bulb formation (HP:0003383)1.79357431
110Abnormality of salivation (HP:0100755)1.77193641
111Ventricular fibrillation (HP:0001663)1.76898035
112Clumsiness (HP:0002312)1.75926033
113Esotropia (HP:0000565)1.75675696
114Postural tremor (HP:0002174)1.75259973
115Increased circulating renin level (HP:0000848)1.74071745
116Thickened helices (HP:0000391)1.74051271
117Hypoventilation (HP:0002791)1.73866545
118Split foot (HP:0001839)1.73820609
119Pointed chin (HP:0000307)1.73417464
120Failure to thrive in infancy (HP:0001531)1.73012968
121Hypoplasia of the corpus callosum (HP:0002079)1.72085813
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72033828
123Paraplegia (HP:0010550)1.62879671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.92177419
2EPHA43.43018588
3MAP3K93.38071316
4MARK13.10716155
5MAP3K42.99052943
6PNCK2.53521325
7MAP2K72.45110771
8MINK12.38200620
9NTRK22.17602620
10NTRK12.17320045
11PAK62.15422104
12CASK1.94983963
13TNIK1.92740256
14OXSR11.89282281
15MAP3K121.86958087
16STK391.86000403
17MAP2K41.81627679
18DAPK21.77209210
19CDK191.73257828
20KSR21.70853741
21UHMK11.56763664
22CDK51.56126265
23GRK51.50473722
24RIPK41.47900767
25PRKD31.44125851
26ARAF1.38861172
27PLK21.37061048
28DYRK21.34568867
29MAPK131.32362614
30PRPF4B1.32186755
31CAMKK11.30776571
32FES1.27072713
33KSR11.19775364
34TYRO31.19448644
35CAMK2A1.16643346
36CAMK2B1.16011464
37CSNK1G21.14167997
38PHKG11.10703940
39PHKG21.10703940
40PRKCG1.10415013
41MAPKAPK51.09388501
42SIK21.09162035
43MAP3K131.08848210
44CAMKK21.04760370
45WNK11.04382189
46SGK2231.02743595
47SGK4941.02743595
48PKN11.01529355
49CDK140.98848165
50CDK150.97839552
51CDK180.97032382
52PAK30.93588369
53STK110.90067349
54STK380.89814083
55MAP3K20.89717786
56WNK40.88483674
57BCR0.87997936
58CAMK2D0.87348297
59CDK11A0.85807486
60PRKCH0.85279953
61CSNK1G30.83147480
62DAPK10.82999773
63RIPK10.81843142
64NEK60.80621216
65FGR0.79107539
66CAMK10.77062599
67DYRK1A0.76597314
68CAMK1G0.73617381
69CAMK2G0.72986000
70MARK20.72523609
71ROCK20.72240832
72FGFR20.72075060
73RET0.71905291
74BRSK10.69009045
75NME10.68192461
76BMPR20.67219990
77PRKCE0.67114486
78SGK30.66547849
79LATS20.65354522
80PINK10.63755450
81SGK10.62570243
82MAPK120.61118980
83TNK20.60411973
84ALK0.59868825
85PTK2B0.58602476
86PDPK10.58348636
87CAMK40.58161845
88WNK30.57171041
89CSNK1A1L0.55928602
90MUSK0.55051365
91FYN0.55047684
92CAMK1D0.53527893
93RAF10.52579477
94LIMK10.51734679
95PDK10.50386757
96CSNK1E0.49817252
97PRKCZ0.48054853
98MAP3K10.48035080
99CSNK1G10.46981588
100RPS6KA30.45862253
101MAPK100.45071109
102MAP3K110.43058236
103CDC42BPA0.42185996
104GRK70.40153521
105CSNK1D0.39783255
106BRAF0.39347414
107MAP3K60.39269710
108DAPK30.39050402
109SGK20.37346716
110PRKG10.36688896
111ICK0.36506636
112PRKACA0.36474013
113RPS6KA20.33097217
114GSK3B0.31361223
115PRKCA0.31297478
116PRKDC0.30197047
117ERBB20.29894073
118MAPK80.29851140
119PRKCB0.27577013
120CSNK1A10.27250940

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85680035
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42312946
3GABAergic synapse_Homo sapiens_hsa047272.96207642
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77635680
5Glutamatergic synapse_Homo sapiens_hsa047242.59151256
6Morphine addiction_Homo sapiens_hsa050322.54172728
7Circadian entrainment_Homo sapiens_hsa047132.51749172
8Olfactory transduction_Homo sapiens_hsa047402.38823692
9Long-term potentiation_Homo sapiens_hsa047202.37329405
10Amphetamine addiction_Homo sapiens_hsa050312.31307699
11Dopaminergic synapse_Homo sapiens_hsa047282.15593724
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06705474
13Salivary secretion_Homo sapiens_hsa049702.05073197
14Serotonergic synapse_Homo sapiens_hsa047261.93686680
15Collecting duct acid secretion_Homo sapiens_hsa049661.91530790
16Insulin secretion_Homo sapiens_hsa049111.88843397
17Taste transduction_Homo sapiens_hsa047421.88186712
18Cocaine addiction_Homo sapiens_hsa050301.86317129
19Cholinergic synapse_Homo sapiens_hsa047251.83206491
20Long-term depression_Homo sapiens_hsa047301.82471763
21Gastric acid secretion_Homo sapiens_hsa049711.78311142
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59128660
23Renin secretion_Homo sapiens_hsa049241.58460600
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53215410
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52598668
26Calcium signaling pathway_Homo sapiens_hsa040201.45407284
27Oxytocin signaling pathway_Homo sapiens_hsa049211.44920828
28Phototransduction_Homo sapiens_hsa047441.34953764
29Cardiac muscle contraction_Homo sapiens_hsa042601.31252968
30Vibrio cholerae infection_Homo sapiens_hsa051101.29445359
31Vitamin B6 metabolism_Homo sapiens_hsa007501.28553773
32Gap junction_Homo sapiens_hsa045401.27877910
33GnRH signaling pathway_Homo sapiens_hsa049121.26589499
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25670118
35Axon guidance_Homo sapiens_hsa043601.23598495
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21452128
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21076996
38Oxidative phosphorylation_Homo sapiens_hsa001901.15799915
39cAMP signaling pathway_Homo sapiens_hsa040241.14795456
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14197082
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03580702
42Type II diabetes mellitus_Homo sapiens_hsa049301.03151620
43Estrogen signaling pathway_Homo sapiens_hsa049151.03015377
44Alzheimers disease_Homo sapiens_hsa050101.00449702
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99207514
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93311634
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92221635
48ErbB signaling pathway_Homo sapiens_hsa040120.91040369
49Pancreatic secretion_Homo sapiens_hsa049720.89573789
50Melanogenesis_Homo sapiens_hsa049160.89342050
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89317398
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88527334
53Parkinsons disease_Homo sapiens_hsa050120.87403485
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.81915952
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81901593
56Dorso-ventral axis formation_Homo sapiens_hsa043200.78584074
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77843988
58Nitrogen metabolism_Homo sapiens_hsa009100.77060076
59Glioma_Homo sapiens_hsa052140.76876612
60Thyroid hormone synthesis_Homo sapiens_hsa049180.73267120
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73260976
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72927283
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67505457
64Type I diabetes mellitus_Homo sapiens_hsa049400.65728331
65Oocyte meiosis_Homo sapiens_hsa041140.64802706
66Butanoate metabolism_Homo sapiens_hsa006500.63956324
67Dilated cardiomyopathy_Homo sapiens_hsa054140.63451248
68Choline metabolism in cancer_Homo sapiens_hsa052310.62203881
69MAPK signaling pathway_Homo sapiens_hsa040100.61684408
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.58113107
71Alcoholism_Homo sapiens_hsa050340.57485667
72Ras signaling pathway_Homo sapiens_hsa040140.56896297
73Ether lipid metabolism_Homo sapiens_hsa005650.56609214
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55589996
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53158343
76Renal cell carcinoma_Homo sapiens_hsa052110.51120368
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49162759
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48339513
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48322976
80Huntingtons disease_Homo sapiens_hsa050160.47844879
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47525894
82Hippo signaling pathway_Homo sapiens_hsa043900.46798588
83Endocytosis_Homo sapiens_hsa041440.46488538
84Inositol phosphate metabolism_Homo sapiens_hsa005620.46470598
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46132022
86Ovarian steroidogenesis_Homo sapiens_hsa049130.43369157
87Prion diseases_Homo sapiens_hsa050200.43005514
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42278688
89Rheumatoid arthritis_Homo sapiens_hsa053230.41015318
90Bile secretion_Homo sapiens_hsa049760.40130929
91Rap1 signaling pathway_Homo sapiens_hsa040150.38791368
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.36597728
93VEGF signaling pathway_Homo sapiens_hsa043700.35387642
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34713235
95Tight junction_Homo sapiens_hsa045300.34707071
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33674648
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33376079
98Wnt signaling pathway_Homo sapiens_hsa043100.32789830
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.31882157
100Glucagon signaling pathway_Homo sapiens_hsa049220.31568206
101Fatty acid elongation_Homo sapiens_hsa000620.31016835
102Arginine and proline metabolism_Homo sapiens_hsa003300.29017621
103Endometrial cancer_Homo sapiens_hsa052130.27988657
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27517115
105African trypanosomiasis_Homo sapiens_hsa051430.26880831
106Hedgehog signaling pathway_Homo sapiens_hsa043400.26737423
107Circadian rhythm_Homo sapiens_hsa047100.24297880
108Mineral absorption_Homo sapiens_hsa049780.23618842
109Chemokine signaling pathway_Homo sapiens_hsa040620.23535672
110AMPK signaling pathway_Homo sapiens_hsa041520.22818584
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22750383
112Fatty acid biosynthesis_Homo sapiens_hsa000610.19597782
113Insulin signaling pathway_Homo sapiens_hsa049100.18481390
114Basal cell carcinoma_Homo sapiens_hsa052170.14949358
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14695749

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »