

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | dopamine transport (GO:0015872) | 9.30538510 |
| 2 | catecholamine biosynthetic process (GO:0042423) | 5.83754059 |
| 3 | catechol-containing compound biosynthetic process (GO:0009713) | 5.83754059 |
| 4 | phenol-containing compound catabolic process (GO:0019336) | 5.72317628 |
| 5 | neurotransmitter biosynthetic process (GO:0042136) | 5.53287961 |
| 6 | behavioral response to nicotine (GO:0035095) | 5.26615488 |
| 7 | synaptic vesicle maturation (GO:0016188) | 5.23652443 |
| 8 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.17064079 |
| 9 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.85104202 |
| 10 | synaptic vesicle exocytosis (GO:0016079) | 4.84077217 |
| 11 | neuronal action potential propagation (GO:0019227) | 4.74456784 |
| 12 | glutamate secretion (GO:0014047) | 4.69175418 |
| 13 | neuron cell-cell adhesion (GO:0007158) | 4.68758015 |
| 14 | neurotransmitter metabolic process (GO:0042133) | 4.66779622 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.43763148 |
| 16 | dopamine metabolic process (GO:0042417) | 4.43484271 |
| 17 | monoamine transport (GO:0015844) | 4.38926401 |
| 18 | neurofilament cytoskeleton organization (GO:0060052) | 4.34690373 |
| 19 | locomotory exploration behavior (GO:0035641) | 4.34129097 |
| 20 | prepulse inhibition (GO:0060134) | 4.29288632 |
| 21 | response to cocaine (GO:0042220) | 4.22273125 |
| 22 | neurotransmitter secretion (GO:0007269) | 4.17521820 |
| 23 | vocalization behavior (GO:0071625) | 4.13580026 |
| 24 | regulation of dopamine metabolic process (GO:0042053) | 4.13218087 |
| 25 | regulation of catecholamine metabolic process (GO:0042069) | 4.13218087 |
| 26 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.00573164 |
| 27 | mating behavior (GO:0007617) | 4.00411693 |
| 28 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.99009646 |
| 29 | regulation of synapse structural plasticity (GO:0051823) | 3.95339521 |
| 30 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.92049400 |
| 31 | regulation of synaptic vesicle transport (GO:1902803) | 3.90890647 |
| 32 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.87246821 |
| 33 | response to insecticide (GO:0017085) | 3.85830118 |
| 34 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.84200417 |
| 35 | cell migration in hindbrain (GO:0021535) | 3.84189130 |
| 36 | gamma-aminobutyric acid transport (GO:0015812) | 3.83543466 |
| 37 | membrane depolarization during action potential (GO:0086010) | 3.83522252 |
| 38 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.81293497 |
| 39 | protein localization to synapse (GO:0035418) | 3.78937906 |
| 40 | neuronal action potential (GO:0019228) | 3.78851017 |
| 41 | postsynaptic membrane organization (GO:0001941) | 3.77624156 |
| 42 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.75150480 |
| 43 | proline transport (GO:0015824) | 3.72113578 |
| 44 | alkaloid metabolic process (GO:0009820) | 3.70781284 |
| 45 | glycine transport (GO:0015816) | 3.69593543 |
| 46 | synaptic transmission, dopaminergic (GO:0001963) | 3.69199468 |
| 47 | cellular response to nicotine (GO:0071316) | 3.68012095 |
| 48 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.67580169 |
| 49 | neuromuscular process controlling posture (GO:0050884) | 3.66369245 |
| 50 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.66208456 |
| 51 | negative regulation of neurotransmitter transport (GO:0051589) | 3.65728370 |
| 52 | regulation of dopamine secretion (GO:0014059) | 3.61379320 |
| 53 | cellular potassium ion homeostasis (GO:0030007) | 3.60130506 |
| 54 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.59427958 |
| 55 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.58148677 |
| 56 | response to nicotine (GO:0035094) | 3.58120020 |
| 57 | exploration behavior (GO:0035640) | 3.57499350 |
| 58 | phenol-containing compound biosynthetic process (GO:0046189) | 3.56713893 |
| 59 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.56390881 |
| 60 | presynaptic membrane assembly (GO:0097105) | 3.56360679 |
| 61 | response to manganese ion (GO:0010042) | 3.55281888 |
| 62 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.54156552 |
| 63 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.51477890 |
| 64 | synaptic transmission, cholinergic (GO:0007271) | 3.51281073 |
| 65 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.50458520 |
| 66 | response to water (GO:0009415) | 3.49536549 |
| 67 | neuron-neuron synaptic transmission (GO:0007270) | 3.49444754 |
| 68 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.47396419 |
| 69 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.47354855 |
| 70 | tyrosine metabolic process (GO:0006570) | 3.46884762 |
| 71 | * neurotransmitter transport (GO:0006836) | 3.46009244 |
| 72 | regulation of neurotransmitter levels (GO:0001505) | 3.43828225 |
| 73 | striatum development (GO:0021756) | 3.43576640 |
| 74 | negative regulation of microtubule polymerization (GO:0031115) | 3.43342221 |
| 75 | presynaptic membrane organization (GO:0097090) | 3.37190105 |
| 76 | transmission of nerve impulse (GO:0019226) | 3.36655677 |
| 77 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.36099492 |
| 78 | short-term memory (GO:0007614) | 3.34120956 |
| 79 | layer formation in cerebral cortex (GO:0021819) | 3.32613867 |
| 80 | detection of temperature stimulus (GO:0016048) | 3.30819445 |
| 81 | axon cargo transport (GO:0008088) | 3.30661055 |
| 82 | adult walking behavior (GO:0007628) | 3.29290155 |
| 83 | activation of protein kinase A activity (GO:0034199) | 3.28937698 |
| 84 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.28530165 |
| 85 | response to auditory stimulus (GO:0010996) | 3.28357344 |
| 86 | negative regulation of dendrite development (GO:2000171) | 3.26591500 |
| 87 | sodium ion export (GO:0071436) | 3.25172723 |
| 88 | neuromuscular process controlling balance (GO:0050885) | 3.24793431 |
| 89 | neuromuscular synaptic transmission (GO:0007274) | 3.24772509 |
| 90 | serotonin metabolic process (GO:0042428) | 3.22344133 |
| 91 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.21066157 |
| 92 | synaptic transmission, glutamatergic (GO:0035249) | 3.20814263 |
| 93 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 3.20559228 |
| 94 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 3.20559228 |
| 95 | C4-dicarboxylate transport (GO:0015740) | 3.19953857 |
| 96 | vesicle transport along microtubule (GO:0047496) | 3.19586017 |
| 97 | regulation of neurotransmitter secretion (GO:0046928) | 3.15561022 |
| 98 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.15304543 |
| 99 | regulation of neurotransmitter transport (GO:0051588) | 3.15240209 |
| 100 | auditory behavior (GO:0031223) | 3.14195544 |
| 101 | membrane hyperpolarization (GO:0060081) | 3.12852808 |
| 102 | startle response (GO:0001964) | 3.12039657 |
| 103 | dopamine biosynthetic process (GO:0042416) | 3.11838634 |
| 104 | regulation of vesicle fusion (GO:0031338) | 3.11065669 |
| 105 | membrane depolarization (GO:0051899) | 3.10830082 |
| 106 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.09162161 |
| 107 | toxin metabolic process (GO:0009404) | 3.09009817 |
| 108 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.08315493 |
| 109 | response to amphetamine (GO:0001975) | 3.08164568 |
| 110 | innervation (GO:0060384) | 3.07219369 |
| 111 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.06451103 |
| 112 | glutamate receptor signaling pathway (GO:0007215) | 3.06085887 |
| 113 | neuronal ion channel clustering (GO:0045161) | 3.04780569 |
| 114 | norepinephrine metabolic process (GO:0042415) | 3.04376523 |
| 115 | positive regulation of potassium ion transport (GO:0043268) | 3.02950764 |
| 116 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.01759733 |
| 117 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.01354827 |
| 118 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.01167092 |
| 119 | membrane repolarization (GO:0086009) | 3.00159341 |
| 120 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.99783279 |
| 121 | dopamine receptor signaling pathway (GO:0007212) | 2.99397569 |
| 122 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.99253836 |
| 123 | positive regulation of neurotransmitter transport (GO:0051590) | 2.98689692 |
| 124 | synaptic vesicle endocytosis (GO:0048488) | 2.96606508 |
| 125 | behavioral response to cocaine (GO:0048148) | 2.95296124 |
| 126 | regulation of protein kinase A signaling (GO:0010738) | 2.93870809 |
| 127 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.92518460 |
| 128 | organelle transport along microtubule (GO:0072384) | 2.92515206 |
| 129 | regulation of postsynaptic membrane potential (GO:0060078) | 2.91402814 |
| 130 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.90970034 |
| 131 | fucose catabolic process (GO:0019317) | 2.90680963 |
| 132 | L-fucose metabolic process (GO:0042354) | 2.90680963 |
| 133 | L-fucose catabolic process (GO:0042355) | 2.90680963 |
| 134 | synapse assembly (GO:0007416) | 2.90110362 |
| 135 | neuromuscular process (GO:0050905) | 2.89914007 |
| 136 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.89730234 |
| 137 | neuron recognition (GO:0008038) | 2.89660249 |
| 138 | primary amino compound metabolic process (GO:1901160) | 2.89414476 |
| 139 | behavioral response to ethanol (GO:0048149) | 2.89183367 |
| 140 | synaptic transmission (GO:0007268) | 2.88370749 |
| 141 | catecholamine transport (GO:0051937) | 2.88191769 |
| 142 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.86679370 |
| 143 | catecholamine metabolic process (GO:0006584) | 2.85216960 |
| 144 | catechol-containing compound metabolic process (GO:0009712) | 2.85216960 |
| 145 | cell differentiation in hindbrain (GO:0021533) | 2.78848578 |
| 146 | adult behavior (GO:0030534) | 2.76341548 |
| 147 | action potential (GO:0001508) | 2.74941657 |
| 148 | response to corticosterone (GO:0051412) | 2.74755729 |
| 149 | urinary tract smooth muscle contraction (GO:0014848) | 2.72574420 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.27404987 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.39815451 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.24165924 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.11513562 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.04768467 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.83096257 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.83096257 |
| 8 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.76727815 |
| 9 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.63009034 |
| 10 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.62205993 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.57471878 |
| 12 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.56324327 |
| 13 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.52721326 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.51491910 |
| 15 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.43222123 |
| 16 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.27129810 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.23927118 |
| 18 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.22398191 |
| 19 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.21104351 |
| 20 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.20350762 |
| 21 | * TAF15_26573619_Chip-Seq_HEK293_Human | 2.13626161 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11725996 |
| 23 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.05867476 |
| 24 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.97960626 |
| 25 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.89798141 |
| 26 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.86908227 |
| 27 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.85215947 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.81342279 |
| 29 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.80368352 |
| 30 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.74318683 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.72536212 |
| 32 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.70878005 |
| 33 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.65475430 |
| 34 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62315355 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.61881719 |
| 36 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.59194567 |
| 37 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.58327507 |
| 38 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.58166497 |
| 39 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.52045434 |
| 40 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.47024477 |
| 41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.46452803 |
| 42 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.44521968 |
| 43 | P300_19829295_ChIP-Seq_ESCs_Human | 1.42869126 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.41389631 |
| 45 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.40283426 |
| 46 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.39012582 |
| 47 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.38650384 |
| 48 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38650384 |
| 49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.38237268 |
| 50 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.36979471 |
| 51 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.36935494 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.36715196 |
| 53 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.32145775 |
| 54 | EWS_26573619_Chip-Seq_HEK293_Human | 1.29020525 |
| 55 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.26577603 |
| 56 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.25618527 |
| 57 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.25345774 |
| 58 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25333564 |
| 59 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.25295596 |
| 60 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.24911282 |
| 61 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.24813684 |
| 62 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.24740738 |
| 63 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.24516022 |
| 64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24088890 |
| 65 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.21050256 |
| 66 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.20932350 |
| 67 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.18183159 |
| 68 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.17911083 |
| 69 | AR_25329375_ChIP-Seq_VCAP_Human | 1.16290819 |
| 70 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.14123578 |
| 71 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.13601738 |
| 72 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.13193066 |
| 73 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.13096575 |
| 74 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.12634762 |
| 75 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.11287574 |
| 76 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.10594001 |
| 77 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.10252682 |
| 78 | AR_19668381_ChIP-Seq_PC3_Human | 1.09579363 |
| 79 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.07970035 |
| 80 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.07952478 |
| 81 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.06518735 |
| 82 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05683555 |
| 83 | * CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.05353926 |
| 84 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.05294202 |
| 85 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.05266935 |
| 86 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.05266935 |
| 87 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.04638284 |
| 88 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.04596126 |
| 89 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.04341686 |
| 90 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.04215897 |
| 91 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04005077 |
| 92 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.03463758 |
| 93 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.03407857 |
| 94 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.02577352 |
| 95 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02555312 |
| 96 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.00582141 |
| 97 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.00193374 |
| 98 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.00189196 |
| 99 | KDM2B_26808549_Chip-Seq_REH_Human | 0.99826745 |
| 100 | KDM2B_26808549_Chip-Seq_K562_Human | 0.99792862 |
| 101 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99274789 |
| 102 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.98726687 |
| 103 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.98595289 |
| 104 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.98396843 |
| 105 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.97788942 |
| 106 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.97756946 |
| 107 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97495117 |
| 108 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97244871 |
| 109 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.97145148 |
| 110 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.97113846 |
| 111 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97019889 |
| 112 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.96733474 |
| 113 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.96733474 |
| 114 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.95919191 |
| 115 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.95871362 |
| 116 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95232923 |
| 117 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.94695224 |
| 118 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.94604519 |
| 119 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.92464852 |
| 120 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.89016920 |
| 121 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.87406846 |
| 122 | JUN_21703547_ChIP-Seq_K562_Human | 0.87336500 |
| 123 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.86061284 |
| 124 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.85528009 |
| 125 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.84343423 |
| 126 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.84162167 |
| 127 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.84124647 |
| 128 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.83508356 |
| 129 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.82814090 |
| 130 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.81975887 |
| 131 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.80939933 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.92946670 |
| 2 | MP0003880_abnormal_central_pattern | 4.55710703 |
| 3 | MP0001968_abnormal_touch/_nociception | 4.19071681 |
| 4 | MP0002822_catalepsy | 3.95729906 |
| 5 | MP0002735_abnormal_chemical_nociception | 3.88126684 |
| 6 | MP0004270_analgesia | 3.84241597 |
| 7 | MP0003635_abnormal_synaptic_transmissio | 3.52517165 |
| 8 | MP0002736_abnormal_nociception_after | 3.40535709 |
| 9 | MP0002734_abnormal_mechanical_nocicepti | 3.15531830 |
| 10 | MP0009046_muscle_twitch | 3.08475449 |
| 11 | MP0009745_abnormal_behavioral_response | 3.05168590 |
| 12 | MP0002733_abnormal_thermal_nociception | 3.01395142 |
| 13 | MP0002064_seizures | 2.81581395 |
| 14 | MP0006276_abnormal_autonomic_nervous | 2.78022993 |
| 15 | MP0005423_abnormal_somatic_nervous | 2.71479956 |
| 16 | MP0002272_abnormal_nervous_system | 2.70727231 |
| 17 | MP0001970_abnormal_pain_threshold | 2.70631320 |
| 18 | MP0002063_abnormal_learning/memory/cond | 2.65869638 |
| 19 | MP0004858_abnormal_nervous_system | 2.55705771 |
| 20 | MP0002572_abnormal_emotion/affect_behav | 2.39754163 |
| 21 | MP0001486_abnormal_startle_reflex | 2.34129807 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.15790046 |
| 23 | MP0002184_abnormal_innervation | 2.08376792 |
| 24 | MP0001529_abnormal_vocalization | 2.00264745 |
| 25 | MP0001440_abnormal_grooming_behavior | 1.94553182 |
| 26 | MP0001501_abnormal_sleep_pattern | 1.94400039 |
| 27 | MP0001905_abnormal_dopamine_level | 1.93895918 |
| 28 | MP0004924_abnormal_behavior | 1.82095379 |
| 29 | MP0005386_behavior/neurological_phenoty | 1.82095379 |
| 30 | MP0002909_abnormal_adrenal_gland | 1.80510069 |
| 31 | MP0001986_abnormal_taste_sensitivity | 1.76636423 |
| 32 | MP0004811_abnormal_neuron_physiology | 1.74369601 |
| 33 | MP0000955_abnormal_spinal_cord | 1.70067146 |
| 34 | MP0001984_abnormal_olfaction | 1.66958242 |
| 35 | MP0008569_lethality_at_weaning | 1.63443695 |
| 36 | MP0005646_abnormal_pituitary_gland | 1.61756202 |
| 37 | MP0003329_amyloid_beta_deposits | 1.59733350 |
| 38 | MP0000778_abnormal_nervous_system | 1.56974866 |
| 39 | MP0002557_abnormal_social/conspecific_i | 1.56193634 |
| 40 | MP0004142_abnormal_muscle_tone | 1.46856294 |
| 41 | MP0008877_abnormal_DNA_methylation | 1.44294317 |
| 42 | MP0001188_hyperpigmentation | 1.41636956 |
| 43 | MP0002882_abnormal_neuron_morphology | 1.38842603 |
| 44 | MP0002102_abnormal_ear_morphology | 1.35891981 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.33624666 |
| 46 | MP0000566_synostosis | 1.31589980 |
| 47 | MP0005187_abnormal_penis_morphology | 1.29955600 |
| 48 | MP0003633_abnormal_nervous_system | 1.26835479 |
| 49 | MP0008872_abnormal_physiological_respon | 1.24759850 |
| 50 | MP0002751_abnormal_autonomic_nervous | 1.23011202 |
| 51 | MP0004043_abnormal_pH_regulation | 1.22017506 |
| 52 | MP0002837_dystrophic_cardiac_calcinosis | 1.17398925 |
| 53 | MP0006072_abnormal_retinal_apoptosis | 1.15764137 |
| 54 | MP0000920_abnormal_myelination | 1.14057198 |
| 55 | MP0002229_neurodegeneration | 1.14032865 |
| 56 | MP0003136_yellow_coat_color | 1.13042306 |
| 57 | MP0005409_darkened_coat_color | 1.12974790 |
| 58 | MP0005645_abnormal_hypothalamus_physiol | 1.12593369 |
| 59 | MP0003011_delayed_dark_adaptation | 1.09412336 |
| 60 | MP0003631_nervous_system_phenotype | 1.08811081 |
| 61 | MP0004885_abnormal_endolymph | 1.07764833 |
| 62 | MP0009780_abnormal_chondrocyte_physiolo | 1.07512611 |
| 63 | MP0003879_abnormal_hair_cell | 1.06171579 |
| 64 | MP0008874_decreased_physiological_sensi | 1.04525968 |
| 65 | MP0004742_abnormal_vestibular_system | 1.02834432 |
| 66 | MP0003634_abnormal_glial_cell | 1.02436027 |
| 67 | MP0002876_abnormal_thyroid_physiology | 1.00582429 |
| 68 | MP0001502_abnormal_circadian_rhythm | 0.99424571 |
| 69 | MP0003122_maternal_imprinting | 0.97819003 |
| 70 | MP0005253_abnormal_eye_physiology | 0.97810382 |
| 71 | MP0000751_myopathy | 0.95804472 |
| 72 | MP0004215_abnormal_myocardial_fiber | 0.94898762 |
| 73 | MP0001664_abnormal_digestion | 0.92442576 |
| 74 | MP0002752_abnormal_somatic_nervous | 0.91758904 |
| 75 | MP0001299_abnormal_eye_distance/ | 0.91479654 |
| 76 | MP0008875_abnormal_xenobiotic_pharmacok | 0.90976843 |
| 77 | MP0004145_abnormal_muscle_electrophysio | 0.87546751 |
| 78 | MP0002152_abnormal_brain_morphology | 0.83126779 |
| 79 | MP0004133_heterotaxia | 0.82572711 |
| 80 | MP0001348_abnormal_lacrimal_gland | 0.82295644 |
| 81 | MP0005535_abnormal_body_temperature | 0.82012694 |
| 82 | MP0010386_abnormal_urinary_bladder | 0.81662580 |
| 83 | MP0000427_abnormal_hair_cycle | 0.80809421 |
| 84 | MP0000569_abnormal_digit_pigmentation | 0.80620906 |
| 85 | MP0002638_abnormal_pupillary_reflex | 0.78181103 |
| 86 | MP0001963_abnormal_hearing_physiology | 0.78123176 |
| 87 | MP0003632_abnormal_nervous_system | 0.77218242 |
| 88 | MP0003690_abnormal_glial_cell | 0.76432935 |
| 89 | MP0002069_abnormal_eating/drinking_beha | 0.76125401 |
| 90 | MP0000026_abnormal_inner_ear | 0.75088911 |
| 91 | MP0004085_abnormal_heartbeat | 0.73159941 |
| 92 | MP0003183_abnormal_peptide_metabolism | 0.72273490 |
| 93 | MP0002160_abnormal_reproductive_system | 0.71936698 |
| 94 | MP0001177_atelectasis | 0.71863397 |
| 95 | MP0000013_abnormal_adipose_tissue | 0.71033021 |
| 96 | MP0003195_calcinosis | 0.70901539 |
| 97 | MP0005551_abnormal_eye_electrophysiolog | 0.70456308 |
| 98 | MP0005394_taste/olfaction_phenotype | 0.69377130 |
| 99 | MP0005499_abnormal_olfactory_system | 0.69377130 |
| 100 | MP0000534_abnormal_ureter_morphology | 0.69351427 |
| 101 | MP0000604_amyloidosis | 0.68993943 |
| 102 | MP0003121_genomic_imprinting | 0.68012934 |
| 103 | MP0003787_abnormal_imprinting | 0.66220410 |
| 104 | MP0000230_abnormal_systemic_arterial | 0.64844241 |
| 105 | MP0001270_distended_abdomen | 0.64195383 |
| 106 | MP0001485_abnormal_pinna_reflex | 0.63182087 |
| 107 | MP0005084_abnormal_gallbladder_morpholo | 0.61449676 |
| 108 | MP0003119_abnormal_digestive_system | 0.61188072 |
| 109 | MP0000747_muscle_weakness | 0.60220374 |
| 110 | MP0003861_abnormal_nervous_system | 0.60170164 |
| 111 | MP0002234_abnormal_pharynx_morphology | 0.59153398 |
| 112 | MP0008961_abnormal_basal_metabolism | 0.58140805 |
| 113 | MP0002938_white_spotting | 0.57994440 |
| 114 | MP0004147_increased_porphyrin_level | 0.57299544 |
| 115 | MP0000631_abnormal_neuroendocrine_gland | 0.57264387 |
| 116 | MP0002090_abnormal_vision | 0.57263812 |
| 117 | MP0006035_abnormal_mitochondrial_morpho | 0.56706205 |
| 118 | MP0005623_abnormal_meninges_morphology | 0.54452112 |
| 119 | MP0000538_abnormal_urinary_bladder | 0.54187412 |
| 120 | MP0001943_abnormal_respiration | 0.53945321 |
| 121 | MP0003045_fibrosis | 0.53359492 |
| 122 | MP0003283_abnormal_digestive_organ | 0.51183824 |
| 123 | MP0003172_abnormal_lysosome_physiology | 0.50590084 |
| 124 | MP0005410_abnormal_fertilization | 0.50092870 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.49661558 |
| 126 | MP0005171_absent_coat_pigmentation | 0.45507473 |
| 127 | MP0008260_abnormal_autophagy | 0.43839415 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.99517284 |
| 2 | Focal motor seizures (HP:0011153) | 5.87442136 |
| 3 | Limb dystonia (HP:0002451) | 5.52312881 |
| 4 | Focal seizures (HP:0007359) | 5.10722791 |
| 5 | Pheochromocytoma (HP:0002666) | 4.94968119 |
| 6 | Action tremor (HP:0002345) | 4.85384484 |
| 7 | Febrile seizures (HP:0002373) | 4.63574477 |
| 8 | Ulnar claw (HP:0001178) | 4.50324423 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.39958388 |
| 10 | Neuroendocrine neoplasm (HP:0100634) | 4.39380503 |
| 11 | Visual hallucinations (HP:0002367) | 4.10327398 |
| 12 | Hypokinesia (HP:0002375) | 4.03844158 |
| 13 | Atonic seizures (HP:0010819) | 3.98104704 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.97690122 |
| 15 | Ankle clonus (HP:0011448) | 3.76692693 |
| 16 | Insidious onset (HP:0003587) | 3.69032493 |
| 17 | Termporal pattern (HP:0011008) | 3.69032493 |
| 18 | Dyskinesia (HP:0100660) | 3.62343569 |
| 19 | Generalized tonic-clonic seizures (HP:0002069) | 3.42365368 |
| 20 | Epileptic encephalopathy (HP:0200134) | 3.32968100 |
| 21 | Hyperventilation (HP:0002883) | 3.27136092 |
| 22 | Absence seizures (HP:0002121) | 3.23759233 |
| 23 | Truncal ataxia (HP:0002078) | 3.16435816 |
| 24 | Diminished movement (HP:0002374) | 3.14575064 |
| 25 | Failure to thrive in infancy (HP:0001531) | 3.11705485 |
| 26 | Delayed gross motor development (HP:0002194) | 3.06955870 |
| 27 | Dialeptic seizures (HP:0011146) | 3.02389575 |
| 28 | Torticollis (HP:0000473) | 3.01245804 |
| 29 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.93143505 |
| 30 | Anxiety (HP:0000739) | 2.92222998 |
| 31 | Hypothermia (HP:0002045) | 2.83885259 |
| 32 | Urinary urgency (HP:0000012) | 2.82969428 |
| 33 | Depression (HP:0000716) | 2.82274086 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.81131520 |
| 35 | Gaze-evoked nystagmus (HP:0000640) | 2.79863021 |
| 36 | Akinesia (HP:0002304) | 2.79745341 |
| 37 | Spastic gait (HP:0002064) | 2.75306364 |
| 38 | Hypercortisolism (HP:0001578) | 2.71630421 |
| 39 | Dysmetria (HP:0001310) | 2.69499874 |
| 40 | Hammertoe (HP:0001765) | 2.68377627 |
| 41 | Type II lissencephaly (HP:0007260) | 2.65624552 |
| 42 | Scanning speech (HP:0002168) | 2.63439547 |
| 43 | Craniofacial dystonia (HP:0012179) | 2.62680449 |
| 44 | Focal dystonia (HP:0004373) | 2.61692656 |
| 45 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.61463874 |
| 46 | Progressive inability to walk (HP:0002505) | 2.58169900 |
| 47 | Abnormality of the corticospinal tract (HP:0002492) | 2.55354644 |
| 48 | Amblyopia (HP:0000646) | 2.54388079 |
| 49 | Hypoventilation (HP:0002791) | 2.53864377 |
| 50 | Postural tremor (HP:0002174) | 2.52205882 |
| 51 | Onion bulb formation (HP:0003383) | 2.52189398 |
| 52 | Polyphagia (HP:0002591) | 2.51821502 |
| 53 | Status epilepticus (HP:0002133) | 2.51468524 |
| 54 | Hemiplegia (HP:0002301) | 2.49719041 |
| 55 | Drooling (HP:0002307) | 2.49514002 |
| 56 | Abnormality of pain sensation (HP:0010832) | 2.49444624 |
| 57 | Impaired pain sensation (HP:0007328) | 2.49444624 |
| 58 | Abnormal eating behavior (HP:0100738) | 2.47558943 |
| 59 | Abnormality of binocular vision (HP:0011514) | 2.47171514 |
| 60 | Diplopia (HP:0000651) | 2.47171514 |
| 61 | Dysdiadochokinesis (HP:0002075) | 2.45508364 |
| 62 | Poor eye contact (HP:0000817) | 2.44543369 |
| 63 | Peripheral hypomyelination (HP:0007182) | 2.43299031 |
| 64 | Papilledema (HP:0001085) | 2.40842514 |
| 65 | Foot dorsiflexor weakness (HP:0009027) | 2.40678176 |
| 66 | Postural instability (HP:0002172) | 2.39797645 |
| 67 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.39636703 |
| 68 | Muscular hypotonia of the trunk (HP:0008936) | 2.39505820 |
| 69 | Molar tooth sign on MRI (HP:0002419) | 2.38865691 |
| 70 | Abnormality of midbrain morphology (HP:0002418) | 2.38865691 |
| 71 | Steppage gait (HP:0003376) | 2.37339081 |
| 72 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.32716067 |
| 73 | Myotonia (HP:0002486) | 2.30747013 |
| 74 | Oligodactyly (hands) (HP:0001180) | 2.30676249 |
| 75 | Facial shape deformation (HP:0011334) | 2.29987869 |
| 76 | Potter facies (HP:0002009) | 2.29987869 |
| 77 | Impaired smooth pursuit (HP:0007772) | 2.29841936 |
| 78 | Bradykinesia (HP:0002067) | 2.29504268 |
| 79 | Mutism (HP:0002300) | 2.28231844 |
| 80 | Pancreatic cysts (HP:0001737) | 2.28151466 |
| 81 | Abnormal social behavior (HP:0012433) | 2.27882355 |
| 82 | Impaired social interactions (HP:0000735) | 2.27882355 |
| 83 | Excessive salivation (HP:0003781) | 2.26916441 |
| 84 | Cerebral hemorrhage (HP:0001342) | 2.26137310 |
| 85 | Broad-based gait (HP:0002136) | 2.24043687 |
| 86 | Gait imbalance (HP:0002141) | 2.23568975 |
| 87 | Lower limb muscle weakness (HP:0007340) | 2.22767806 |
| 88 | Resting tremor (HP:0002322) | 2.21298046 |
| 89 | Epileptiform EEG discharges (HP:0011182) | 2.21031319 |
| 90 | Medial flaring of the eyebrow (HP:0010747) | 2.20940682 |
| 91 | Ventricular fibrillation (HP:0001663) | 2.19998822 |
| 92 | Congenital stationary night blindness (HP:0007642) | 2.19887141 |
| 93 | Protruding tongue (HP:0010808) | 2.18331949 |
| 94 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 2.16924947 |
| 95 | Nephronophthisis (HP:0000090) | 2.16177917 |
| 96 | Abnormality of the foot musculature (HP:0001436) | 2.14612908 |
| 97 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.13414627 |
| 98 | Agitation (HP:0000713) | 2.13134072 |
| 99 | Hypoplasia of the brainstem (HP:0002365) | 2.11141678 |
| 100 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.11141678 |
| 101 | Pancreatic fibrosis (HP:0100732) | 2.10541125 |
| 102 | Rigidity (HP:0002063) | 2.09833176 |
| 103 | EEG with generalized epileptiform discharges (HP:0011198) | 2.06364238 |
| 104 | Fetal akinesia sequence (HP:0001989) | 2.06235818 |
| 105 | Distal sensory impairment (HP:0002936) | 2.06218460 |
| 106 | Genetic anticipation (HP:0003743) | 2.05440769 |
| 107 | Oligodactyly (HP:0012165) | 2.05145857 |
| 108 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.05135933 |
| 109 | Annular pancreas (HP:0001734) | 2.03809623 |
| 110 | Gastroesophageal reflux (HP:0002020) | 2.03786514 |
| 111 | Inability to walk (HP:0002540) | 2.02429878 |
| 112 | Decreased motor nerve conduction velocity (HP:0003431) | 2.00230245 |
| 113 | Clonus (HP:0002169) | 1.98998764 |
| 114 | Intention tremor (HP:0002080) | 1.97655456 |
| 115 | Split foot (HP:0001839) | 1.97271479 |
| 116 | Hypsarrhythmia (HP:0002521) | 1.96819712 |
| 117 | Prolonged QT interval (HP:0001657) | 1.94717764 |
| 118 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.94363946 |
| 119 | Neurofibrillary tangles (HP:0002185) | 1.93933572 |
| 120 | True hermaphroditism (HP:0010459) | 1.93532484 |
| 121 | Exotropia (HP:0000577) | 1.92725471 |
| 122 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.91481193 |
| 123 | Retinal dysplasia (HP:0007973) | 1.90834136 |
| 124 | Gait ataxia (HP:0002066) | 1.90262575 |
| 125 | Absent speech (HP:0001344) | 1.89090911 |
| 126 | Abnormality of saccadic eye movements (HP:0000570) | 1.88322410 |
| 127 | Abnormality of the vocal cords (HP:0008777) | 1.87407284 |
| 128 | Incomplete penetrance (HP:0003829) | 1.86379406 |
| 129 | Athetosis (HP:0002305) | 1.86172616 |
| 130 | Abnormal EKG (HP:0003115) | 1.86087622 |
| 131 | Abnormality of alanine metabolism (HP:0010916) | 1.85271498 |
| 132 | Hyperalaninemia (HP:0003348) | 1.85271498 |
| 133 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.85271498 |
| 134 | Cerebral inclusion bodies (HP:0100314) | 1.85154097 |
| 135 | Vaginal atresia (HP:0000148) | 1.84803322 |
| 136 | Mask-like facies (HP:0000298) | 1.84144226 |
| 137 | Genital tract atresia (HP:0001827) | 1.83937651 |
| 138 | Optic nerve hypoplasia (HP:0000609) | 1.82616863 |
| 139 | Abnormality of the parathyroid morphology (HP:0011766) | 1.82533385 |
| 140 | Abnormal drinking behavior (HP:0030082) | 1.81348374 |
| 141 | Polydipsia (HP:0001959) | 1.81348374 |
| 142 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.81306851 |
| 143 | Bradycardia (HP:0001662) | 1.79991142 |
| 144 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.79213973 |
| 145 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.79213973 |
| 146 | Abnormality of the renal medulla (HP:0100957) | 1.78179516 |
| 147 | Thyroid carcinoma (HP:0002890) | 1.77943402 |
| 148 | Insomnia (HP:0100785) | 1.77925093 |
| 149 | Congenital primary aphakia (HP:0007707) | 1.76631269 |
| 150 | Hemiparesis (HP:0001269) | 1.76131548 |
| 151 | Lissencephaly (HP:0001339) | 1.75085336 |
| 152 | Chronic hepatic failure (HP:0100626) | 1.66657080 |
| 153 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.59184047 |
| 154 | Lipid accumulation in hepatocytes (HP:0006561) | 1.58558889 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.45777083 |
| 2 | MAP3K9 | 3.96321610 |
| 3 | MINK1 | 3.10698239 |
| 4 | EPHA4 | 2.95749741 |
| 5 | FRK | 2.95377396 |
| 6 | NTRK1 | 2.93642536 |
| 7 | KSR2 | 2.64824971 |
| 8 | MAP3K12 | 2.59716623 |
| 9 | GRK5 | 2.58055735 |
| 10 | MAP3K4 | 2.56869363 |
| 11 | BUB1 | 2.33104196 |
| 12 | ARAF | 2.20640051 |
| 13 | MAP2K7 | 2.18529063 |
| 14 | LMTK2 | 2.17673334 |
| 15 | MARK1 | 2.07902408 |
| 16 | PAK6 | 1.91428941 |
| 17 | MAP2K4 | 1.90487367 |
| 18 | MAP3K2 | 1.82495329 |
| 19 | NTRK2 | 1.72963944 |
| 20 | WNK3 | 1.71022474 |
| 21 | RET | 1.69590388 |
| 22 | LATS2 | 1.66352472 |
| 23 | RIPK4 | 1.65639589 |
| 24 | WNK1 | 1.60302644 |
| 25 | PHKG2 | 1.52939486 |
| 26 | PHKG1 | 1.52939486 |
| 27 | CASK | 1.50148953 |
| 28 | CAMKK1 | 1.49042865 |
| 29 | MAPKAPK5 | 1.47827764 |
| 30 | CDK5 | 1.43427043 |
| 31 | DAPK2 | 1.42787098 |
| 32 | STK39 | 1.42665689 |
| 33 | UHMK1 | 1.33268165 |
| 34 | MAPK13 | 1.32738093 |
| 35 | CAMKK2 | 1.32198274 |
| 36 | DYRK2 | 1.30970996 |
| 37 | PRKD3 | 1.21095998 |
| 38 | PNCK | 1.17482981 |
| 39 | TNIK | 1.17184242 |
| 40 | INSRR | 1.13961069 |
| 41 | TLK1 | 1.13760386 |
| 42 | SGK494 | 1.12765693 |
| 43 | SGK223 | 1.12765693 |
| 44 | FES | 1.09672968 |
| 45 | WNK4 | 1.09543868 |
| 46 | LIMK1 | 1.09076877 |
| 47 | CSNK1G2 | 1.06977419 |
| 48 | ACVR1B | 0.98394023 |
| 49 | KSR1 | 0.98017995 |
| 50 | SIK2 | 0.97718723 |
| 51 | CDK14 | 0.97638328 |
| 52 | PRKCG | 0.97636857 |
| 53 | GRK1 | 0.96855937 |
| 54 | PINK1 | 0.93416146 |
| 55 | TRIM28 | 0.92853654 |
| 56 | CAMK2A | 0.92668246 |
| 57 | STK38 | 0.91390964 |
| 58 | CDK18 | 0.91373601 |
| 59 | MAP4K2 | 0.90775697 |
| 60 | CDK15 | 0.89679279 |
| 61 | TAOK1 | 0.89418301 |
| 62 | PLK2 | 0.88203453 |
| 63 | MAP3K1 | 0.87620133 |
| 64 | EPHA3 | 0.86412455 |
| 65 | MAP3K13 | 0.83376711 |
| 66 | SGK2 | 0.83329743 |
| 67 | CAMK2B | 0.82517666 |
| 68 | MAP3K11 | 0.81541533 |
| 69 | ZAK | 0.80330586 |
| 70 | CDK11A | 0.79488440 |
| 71 | BMPR1B | 0.78088277 |
| 72 | PTK2B | 0.75839496 |
| 73 | TAOK3 | 0.72542923 |
| 74 | CSNK1G3 | 0.71145634 |
| 75 | DAPK1 | 0.70874720 |
| 76 | CAMK2G | 0.70137727 |
| 77 | DYRK1A | 0.69988630 |
| 78 | RAF1 | 0.69827099 |
| 79 | RPS6KA5 | 0.68064545 |
| 80 | MAP2K1 | 0.67706195 |
| 81 | PAK3 | 0.66293533 |
| 82 | FGFR2 | 0.64096931 |
| 83 | PRKCH | 0.64035347 |
| 84 | CAMK2D | 0.64003294 |
| 85 | CDK19 | 0.63455974 |
| 86 | TNK2 | 0.62326920 |
| 87 | SGK3 | 0.62255545 |
| 88 | FER | 0.59791041 |
| 89 | STK11 | 0.59104465 |
| 90 | CAMK1G | 0.58852396 |
| 91 | OXSR1 | 0.58558264 |
| 92 | ADRBK1 | 0.58505143 |
| 93 | PRKCE | 0.57944288 |
| 94 | PKN1 | 0.57650875 |
| 95 | CSNK1A1L | 0.57130781 |
| 96 | PRPF4B | 0.57102241 |
| 97 | RPS6KA2 | 0.56476058 |
| 98 | TYRO3 | 0.56128709 |
| 99 | PDPK1 | 0.55287871 |
| 100 | PRKG1 | 0.53950932 |
| 101 | PDK1 | 0.52795798 |
| 102 | SIK3 | 0.52471913 |
| 103 | CSNK1D | 0.52414145 |
| 104 | CDK3 | 0.50792846 |
| 105 | CAMK1 | 0.50350606 |
| 106 | CDC42BPA | 0.49320112 |
| 107 | SCYL2 | 0.49162474 |
| 108 | MATK | 0.48784435 |
| 109 | ALK | 0.48744206 |
| 110 | CSNK1A1 | 0.48347409 |
| 111 | SGK1 | 0.45238605 |
| 112 | ROCK2 | 0.43997523 |
| 113 | ADRBK2 | 0.43417565 |
| 114 | GRK7 | 0.43269957 |
| 115 | PRKCZ | 0.43078377 |
| 116 | MAPK10 | 0.42724727 |
| 117 | MARK2 | 0.42249937 |
| 118 | PRKACB | 0.41036385 |
| 119 | FYN | 0.40958186 |
| 120 | MAPKAPK3 | 0.40058988 |
| 121 | PTK2 | 0.39870569 |
| 122 | PRKAA1 | 0.38710655 |
| 123 | BRAF | 0.38081859 |
| 124 | PRKCA | 0.38046715 |
| 125 | PRKACA | 0.37910791 |
| 126 | BCKDK | 0.37755251 |
| 127 | CSNK1G1 | 0.37307017 |
| 128 | RPS6KA3 | 0.36656792 |
| 129 | MUSK | 0.36223818 |
| 130 | BCR | 0.36086520 |
| 131 | ERBB3 | 0.35345091 |
| 132 | MKNK2 | 0.34344461 |
| 133 | CSNK1E | 0.32963944 |
| 134 | AKT3 | 0.30966209 |
| 135 | PRKACG | 0.26190775 |
| 136 | CHEK2 | 0.22006803 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.65900585 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 2.94767010 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.90627886 |
| 4 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.53485063 |
| 5 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.39201216 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.37983395 |
| 7 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.36518185 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.33063710 |
| 9 | Cocaine addiction_Homo sapiens_hsa05030 | 2.27178187 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.22453334 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.21879667 |
| 12 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.17423275 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 2.17279418 |
| 14 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.14045862 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.04333087 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.98162109 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.96022270 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.89689407 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.76923875 |
| 20 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.68018555 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.65429856 |
| 22 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.63106220 |
| 23 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.60178089 |
| 24 | Long-term depression_Homo sapiens_hsa04730 | 1.55918307 |
| 25 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.55502254 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.52860160 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.50935099 |
| 28 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.48832525 |
| 29 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.48155227 |
| 30 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.46339477 |
| 31 | Gap junction_Homo sapiens_hsa04540 | 1.42775169 |
| 32 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37687059 |
| 33 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.36836259 |
| 34 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.36728352 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.31382614 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.26170612 |
| 37 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.22826158 |
| 38 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.22702492 |
| 39 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.14251143 |
| 40 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.14035388 |
| 41 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.11565534 |
| 42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.08823298 |
| 43 | Parkinsons disease_Homo sapiens_hsa05012 | 1.08202003 |
| 44 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.07890781 |
| 45 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.04937458 |
| 46 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.03839211 |
| 47 | Glioma_Homo sapiens_hsa05214 | 1.00496734 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.99486120 |
| 49 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.99431737 |
| 50 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.99320109 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95954359 |
| 52 | Axon guidance_Homo sapiens_hsa04360 | 0.95737050 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.95034501 |
| 54 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.92828543 |
| 55 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.91112530 |
| 56 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89845547 |
| 57 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.89558757 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.88048357 |
| 59 | Melanogenesis_Homo sapiens_hsa04916 | 0.87982074 |
| 60 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87456105 |
| 61 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.85247972 |
| 62 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.84913728 |
| 63 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.79156134 |
| 64 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.77715006 |
| 65 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.77577845 |
| 66 | Alzheimers disease_Homo sapiens_hsa05010 | 0.77491644 |
| 67 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.76114057 |
| 68 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.76028694 |
| 69 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.75114017 |
| 70 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.74842042 |
| 71 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.74427424 |
| 72 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.74206868 |
| 73 | Alcoholism_Homo sapiens_hsa05034 | 0.72271307 |
| 74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.69965859 |
| 75 | ABC transporters_Homo sapiens_hsa02010 | 0.67978687 |
| 76 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67237014 |
| 77 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66555999 |
| 78 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66186631 |
| 79 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.63717309 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.60129689 |
| 81 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.59623932 |
| 82 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.59107917 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.58485784 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58479883 |
| 85 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.56769015 |
| 86 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.55860845 |
| 87 | Thyroid cancer_Homo sapiens_hsa05216 | 0.55819244 |
| 88 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.55025856 |
| 89 | Bile secretion_Homo sapiens_hsa04976 | 0.54612871 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.54548530 |
| 91 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.54405446 |
| 92 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.53697039 |
| 93 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.53123006 |
| 94 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.53063395 |
| 95 | Protein export_Homo sapiens_hsa03060 | 0.51227184 |
| 96 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.49780964 |
| 97 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.48497186 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.47461647 |
| 99 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.46456399 |
| 100 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.45365063 |
| 101 | Prion diseases_Homo sapiens_hsa05020 | 0.45360227 |
| 102 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44511716 |
| 103 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.44136316 |
| 104 | Endometrial cancer_Homo sapiens_hsa05213 | 0.43891386 |
| 105 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.43875108 |
| 106 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.41780809 |
| 107 | Mineral absorption_Homo sapiens_hsa04978 | 0.41689740 |
| 108 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.41010855 |
| 109 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.40880952 |
| 110 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.40865294 |
| 111 | Melanoma_Homo sapiens_hsa05218 | 0.40805523 |
| 112 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.40067102 |
| 113 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.39470118 |
| 114 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.38525257 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.37875039 |
| 116 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.37112719 |
| 117 | Huntingtons disease_Homo sapiens_hsa05016 | 0.36761141 |
| 118 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.36083197 |
| 119 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.34856876 |
| 120 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.34642431 |
| 121 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.33448103 |
| 122 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33435377 |
| 123 | Peroxisome_Homo sapiens_hsa04146 | 0.33259142 |
| 124 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.32897491 |
| 125 | Phagosome_Homo sapiens_hsa04145 | 0.32791955 |
| 126 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.32407282 |
| 127 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31785412 |
| 128 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31167471 |
| 129 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31119688 |
| 130 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.30097143 |
| 131 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29872591 |
| 132 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.29535372 |
| 133 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28565362 |
| 134 | Basal transcription factors_Homo sapiens_hsa03022 | 0.28294352 |
| 135 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26866447 |
| 136 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.26373270 |

