SVBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.12446908
2viral transcription (GO:0019083)5.71974364
3pyrimidine nucleobase catabolic process (GO:0006208)5.50874039
4translational termination (GO:0006415)5.47679945
5ribosomal small subunit biogenesis (GO:0042274)5.14886810
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85454973
7DNA deamination (GO:0045006)4.81104397
8translational elongation (GO:0006414)4.77515080
9cotranslational protein targeting to membrane (GO:0006613)4.73652485
10protein targeting to ER (GO:0045047)4.71438089
11behavioral response to nicotine (GO:0035095)4.56188568
12protein localization to endoplasmic reticulum (GO:0070972)4.42983633
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42768752
14maturation of SSU-rRNA (GO:0030490)4.41350045
15viral life cycle (GO:0019058)4.38208568
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34834012
17cellular protein complex disassembly (GO:0043624)4.33602857
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.29748042
19nucleobase catabolic process (GO:0046113)4.22665583
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15434768
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.15434768
22NADH dehydrogenase complex assembly (GO:0010257)4.15434768
23sequestering of actin monomers (GO:0042989)4.11297959
24translational initiation (GO:0006413)4.11077865
25protein complex biogenesis (GO:0070271)4.09811878
26ribosomal large subunit biogenesis (GO:0042273)4.06154916
27proteasome assembly (GO:0043248)4.02794826
28protein complex disassembly (GO:0043241)3.83870217
29respiratory electron transport chain (GO:0022904)3.83355307
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78123612
31electron transport chain (GO:0022900)3.77935071
32mitochondrial respiratory chain complex assembly (GO:0033108)3.73710507
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.67487501
34macromolecular complex disassembly (GO:0032984)3.65186063
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63911131
36protein-cofactor linkage (GO:0018065)3.60991598
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.57557047
38ATP synthesis coupled proton transport (GO:0015986)3.57557047
39intraciliary transport (GO:0042073)3.56116677
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55826456
41activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.54664871
42platelet dense granule organization (GO:0060155)3.52242338
43translation (GO:0006412)3.52045424
44nonmotile primary cilium assembly (GO:0035058)3.48677722
45regulation of cilium movement (GO:0003352)3.48318139
46pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.46353780
47positive regulation of mitochondrial fission (GO:0090141)3.42598410
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40985989
49retinal ganglion cell axon guidance (GO:0031290)3.40281564
50protein polyglutamylation (GO:0018095)3.39577092
51establishment of mitochondrion localization (GO:0051654)3.38654167
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34695117
53substrate-independent telencephalic tangential migration (GO:0021826)3.34205970
54substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.34205970
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.33409863
56telomere maintenance via semi-conservative replication (GO:0032201)3.30979976
57negative regulation of ligase activity (GO:0051352)3.26667903
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26667903
59protein localization to cilium (GO:0061512)3.26645336
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26337291
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26337291
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25768836
63ribonucleoprotein complex biogenesis (GO:0022613)3.25656807
64DNA strand elongation involved in DNA replication (GO:0006271)3.25032727
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.24065273
66deoxyribose phosphate biosynthetic process (GO:0046385)3.23882782
672-deoxyribonucleotide biosynthetic process (GO:0009265)3.23882782
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22112106
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22112106
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22112106
71neurofilament cytoskeleton organization (GO:0060052)3.21374605
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21064529
73negative regulation of transcription regulatory region DNA binding (GO:2000678)3.18688905
74epithelial cilium movement (GO:0003351)3.15075126
75somite development (GO:0061053)3.12386664
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10917023
77regulation of cellular amino acid metabolic process (GO:0006521)3.09863561
78mRNA catabolic process (GO:0006402)3.08953726
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07752149
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.07752149
81formation of translation preinitiation complex (GO:0001731)3.07471516
82DNA strand elongation (GO:0022616)3.07439221
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.06972025
84protein targeting to membrane (GO:0006612)3.06374326
85negative regulation of response to food (GO:0032096)3.05441375
86negative regulation of appetite (GO:0032099)3.05441375
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00229891
88axonal fasciculation (GO:0007413)2.99486327
89neural tube formation (GO:0001841)2.99411074
90termination of RNA polymerase III transcription (GO:0006386)2.99407815
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.99407815
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99352851
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99352851
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98096267
95presynaptic membrane organization (GO:0097090)2.92477703
96spliceosomal snRNP assembly (GO:0000387)2.91157786
97telomere maintenance via recombination (GO:0000722)2.89412747
98limb bud formation (GO:0060174)2.89262233
99histone mRNA metabolic process (GO:0008334)2.89254728
100RNA catabolic process (GO:0006401)2.88499126
101deoxyribonucleotide biosynthetic process (GO:0009263)2.87979972
102erythrocyte maturation (GO:0043249)2.85937263
103negative regulation of telomere maintenance (GO:0032205)2.85456529
104DNA double-strand break processing (GO:0000729)2.85258691
105base-excision repair, AP site formation (GO:0006285)2.81157427
106ubiquinone metabolic process (GO:0006743)2.81050205
107pyrimidine nucleotide catabolic process (GO:0006244)2.80993911
108GTP biosynthetic process (GO:0006183)2.77640726
1097-methylguanosine mRNA capping (GO:0006370)2.77592024
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.76777121
111presynaptic membrane assembly (GO:0097105)2.76416782
112cellular component biogenesis (GO:0044085)2.76274933
113hydrogen ion transmembrane transport (GO:1902600)2.76125576
114regulation of microtubule-based movement (GO:0060632)2.75538033
115regulation of protein heterodimerization activity (GO:0043497)2.75308152
116positive regulation of cell cycle arrest (GO:0071158)2.74006706
117ubiquinone biosynthetic process (GO:0006744)2.73184406
118respiratory chain complex IV assembly (GO:0008535)2.73070750
119postsynaptic membrane organization (GO:0001941)2.72686750
120RNA capping (GO:0036260)2.72447133
1217-methylguanosine RNA capping (GO:0009452)2.72447133
122synaptic transmission, cholinergic (GO:0007271)2.71708718
123kinetochore assembly (GO:0051382)2.71280234
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70894194
125regulation of mitochondrial translation (GO:0070129)2.70856808
126neuron cell-cell adhesion (GO:0007158)2.70684113
127dendritic spine morphogenesis (GO:0060997)2.70605312
128neuron recognition (GO:0008038)2.70407384
129olfactory bulb development (GO:0021772)2.69776113
130kinetochore organization (GO:0051383)2.69286940
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69113538
132negative regulation of heart rate (GO:0010459)2.67696044
133transcription-coupled nucleotide-excision repair (GO:0006283)2.67634441
134neuron fate determination (GO:0048664)2.67600293
135protein neddylation (GO:0045116)2.67427529
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67173385
137organelle disassembly (GO:1903008)2.64888114
138rRNA processing (GO:0006364)2.64224626
139cullin deneddylation (GO:0010388)2.64140333
140DNA damage response, detection of DNA damage (GO:0042769)2.62742213
141protein deneddylation (GO:0000338)2.62225118
142positive regulation of ligase activity (GO:0051351)2.62131295
143cilium morphogenesis (GO:0060271)2.60773608
144proton transport (GO:0015992)2.60272107
145antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59311997
146mitotic recombination (GO:0006312)2.59016063
147ATP biosynthetic process (GO:0006754)2.57950647
148transmission of nerve impulse (GO:0019226)2.57475999
149mitochondrion transport along microtubule (GO:0047497)2.56224796
150establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56224796
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.56049907
152DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.55911705
153anterograde synaptic vesicle transport (GO:0048490)2.55823617
154hydrogen transport (GO:0006818)2.55455181
155deoxyribonucleotide catabolic process (GO:0009264)2.55017161
156rRNA metabolic process (GO:0016072)2.54412993
157iron-sulfur cluster assembly (GO:0016226)2.54272747
158metallo-sulfur cluster assembly (GO:0031163)2.54272747
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53709730
160establishment of integrated proviral latency (GO:0075713)2.53500479
161cell proliferation in forebrain (GO:0021846)2.53478706
162pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52812925
1632-deoxyribonucleotide metabolic process (GO:0009394)2.52551056
164viral mRNA export from host cell nucleus (GO:0046784)2.51682000
165short-term memory (GO:0007614)2.51579719
166spinal cord association neuron differentiation (GO:0021527)2.51136352
167CENP-A containing nucleosome assembly (GO:0034080)2.50665770
168piRNA metabolic process (GO:0034587)2.50331433
169chaperone-mediated protein transport (GO:0072321)2.48964143
170axoneme assembly (GO:0035082)2.48809101
171pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48753021
172establishment of viral latency (GO:0019043)2.48531158
173purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.47987730
174cerebral cortex radially oriented cell migration (GO:0021799)2.46426707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.65603670
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10152749
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02913551
4EZH2_22144423_ChIP-Seq_EOC_Human3.96615929
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.64342218
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.64288994
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43300656
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.32108827
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.24923565
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15820266
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.14358891
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.12752025
13IGF1R_20145208_ChIP-Seq_DFB_Human3.11646891
14ZNF274_21170338_ChIP-Seq_K562_Hela2.93929212
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.90448944
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83644338
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73830868
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67445506
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63814801
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63399108
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54009928
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45659189
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43988328
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40492402
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36765545
26VDR_23849224_ChIP-Seq_CD4+_Human2.35532237
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34978662
28XRN2_22483619_ChIP-Seq_HELA_Human2.33261919
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31519005
30DCP1A_22483619_ChIP-Seq_HELA_Human2.30902906
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28729164
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24737338
33VDR_22108803_ChIP-Seq_LS180_Human2.22737785
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19784463
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.18746470
36IRF8_22096565_ChIP-ChIP_GC-B_Human2.14672820
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.13875468
38CBX2_27304074_Chip-Seq_ESCs_Mouse2.13857530
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08134133
40TTF2_22483619_ChIP-Seq_HELA_Human2.06872168
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06063082
42IRF8_21731497_ChIP-ChIP_J774_Mouse2.02061331
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00837624
44SRF_21415370_ChIP-Seq_HL-1_Mouse2.00568109
45NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00376638
46ELK1_19687146_ChIP-ChIP_HELA_Human1.99336623
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97421997
48FUS_26573619_Chip-Seq_HEK293_Human1.97377829
49FOXP3_21729870_ChIP-Seq_TREG_Human1.96276039
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94859961
51RNF2_27304074_Chip-Seq_NSC_Mouse1.91015142
52GBX2_23144817_ChIP-Seq_PC3_Human1.89614143
53TAF15_26573619_Chip-Seq_HEK293_Human1.89224101
54EWS_26573619_Chip-Seq_HEK293_Human1.88101877
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86393554
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85385518
57GABP_19822575_ChIP-Seq_HepG2_Human1.79303469
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76264691
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75862337
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.74978123
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74472096
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72724707
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71248888
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.70316678
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69065761
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64750797
67P300_19829295_ChIP-Seq_ESCs_Human1.62421274
68REST_21632747_ChIP-Seq_MESCs_Mouse1.60439968
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59313064
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57444754
71IRF1_19129219_ChIP-ChIP_H3396_Human1.56837949
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55186114
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53619331
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53012927
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50912761
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46787621
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.45521524
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43893333
79SPI1_23547873_ChIP-Seq_NB4_Human1.43229571
80TP53_22573176_ChIP-Seq_HFKS_Human1.42408540
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.41253613
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.39072749
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38267913
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.35560677
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.34955008
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32767364
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30780400
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30320508
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29588193
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.27667219
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24908981
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24786011
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.22454946
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.22261564
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20767153
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19709820
97CIITA_25753668_ChIP-Seq_RAJI_Human1.19374640
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18429631
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18196030
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17389058
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15938188
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12592004
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11711838
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11456523
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10040551
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10040551
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09842041
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09767324
109EED_16625203_ChIP-ChIP_MESCs_Mouse1.09665440
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09509488
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09042463
112JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08512163
113MYC_18940864_ChIP-ChIP_HL60_Human1.08499144
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07000187
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06364019
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05634272
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05209744
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03880839
119E2F1_21310950_ChIP-Seq_MCF-7_Human1.03814484
120CBP_20019798_ChIP-Seq_JUKART_Human1.03703069
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03703069
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03701285
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03182893
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02560472
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01964836
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01394695
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01375167
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00577695
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99201357
130AR_25329375_ChIP-Seq_VCAP_Human0.98443085
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98043140
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97931098
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97842128
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97221707
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96920816
136VDR_21846776_ChIP-Seq_THP-1_Human0.96910127
137SCL_19346495_ChIP-Seq_HPC-7_Human0.96031311
138SOX2_19829295_ChIP-Seq_ESCs_Human0.96005222
139NANOG_19829295_ChIP-Seq_ESCs_Human0.96005222
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95791855
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94603130
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94296560
143NCOR_22424771_ChIP-Seq_293T_Human0.93727878
144HTT_18923047_ChIP-ChIP_STHdh_Human0.93361248
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.93227821
146ER_23166858_ChIP-Seq_MCF-7_Human0.92231189
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92147716
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91436377
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90705655
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90514105
151SMAD4_21799915_ChIP-Seq_A2780_Human0.90150626
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89556297
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.89250460
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86271633
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85799557
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85060658
157EZH2_27294783_Chip-Seq_ESCs_Mouse0.85038737
158FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84337302
159NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84238066
160LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84074245
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83968545
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83749944
163E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83648107
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.82126512
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80706589
166GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80703485
167BCL6_27268052_Chip-Seq_Bcells_Human0.79718959
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78352516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.10801720
2MP0003880_abnormal_central_pattern2.95380369
3MP0001529_abnormal_vocalization2.91726986
4MP0001835_abnormal_antigen_presentation2.81718472
5MP0003122_maternal_imprinting2.77901072
6MP0005394_taste/olfaction_phenotype2.71833809
7MP0005499_abnormal_olfactory_system2.71833809
8MP0003787_abnormal_imprinting2.65192626
9MP0006276_abnormal_autonomic_nervous2.63227618
10MP0003693_abnormal_embryo_hatching2.59633592
11MP0009785_altered_susceptibility_to2.53831878
12MP0008877_abnormal_DNA_methylation2.42940685
13MP0002653_abnormal_ependyma_morphology2.33667217
14MP0003121_genomic_imprinting2.32922679
15MP0008058_abnormal_DNA_repair2.31466676
16MP0002148_abnormal_hypersensitivity_rea2.26540710
17MP0006054_spinal_hemorrhage2.21844849
18MP0000778_abnormal_nervous_system2.13309874
19MP0008007_abnormal_cellular_replicative2.10515485
20MP0002822_catalepsy2.08390214
21MP0003077_abnormal_cell_cycle2.03826691
22MP0009333_abnormal_splenocyte_physiolog2.03290238
23MP0005410_abnormal_fertilization2.00201221
24MP0001984_abnormal_olfaction1.99359690
25MP0006292_abnormal_olfactory_placode1.96569344
26MP0002736_abnormal_nociception_after1.96512957
27MP0002938_white_spotting1.96015373
28MP0003186_abnormal_redox_activity1.95921677
29MP0002132_abnormal_respiratory_system1.93215771
30MP0002102_abnormal_ear_morphology1.90622707
31MP0010094_abnormal_chromosome_stability1.89753096
32MP0004142_abnormal_muscle_tone1.89318119
33MP0004133_heterotaxia1.88767471
34MP0005000_abnormal_immune_tolerance1.88665737
35MP0005084_abnormal_gallbladder_morpholo1.85779757
36MP0003111_abnormal_nucleus_morphology1.85001618
37MP0003724_increased_susceptibility_to1.81184084
38MP0004957_abnormal_blastocyst_morpholog1.80140089
39MP0005671_abnormal_response_to1.78357328
40MP0005423_abnormal_somatic_nervous1.75642063
41MP0005397_hematopoietic_system_phenotyp1.75620199
42MP0001545_abnormal_hematopoietic_system1.75620199
43MP0003656_abnormal_erythrocyte_physiolo1.75497488
44MP0001968_abnormal_touch/_nociception1.75322767
45MP0005025_abnormal_response_to1.73501330
46MP0000685_abnormal_immune_system1.73253111
47MP0006072_abnormal_retinal_apoptosis1.71633508
48MP0004147_increased_porphyrin_level1.69337738
49MP0003436_decreased_susceptibility_to1.69262458
50MP0009046_muscle_twitch1.62651589
51MP0000490_abnormal_crypts_of1.62413432
52MP0000858_altered_metastatic_potential1.61665243
53MP0001188_hyperpigmentation1.60536983
54MP0005551_abnormal_eye_electrophysiolog1.59560608
55MP0002638_abnormal_pupillary_reflex1.59309039
56MP0005174_abnormal_tail_pigmentation1.59058248
57MP0010030_abnormal_orbit_morphology1.55640875
58MP0002452_abnormal_antigen_presenting1.54995869
59MP0002272_abnormal_nervous_system1.53063297
60MP0008932_abnormal_embryonic_tissue1.53017321
61MP0008995_early_reproductive_senescence1.52217688
62MP0002398_abnormal_bone_marrow1.50735627
63MP0000631_abnormal_neuroendocrine_gland1.50465691
64MP0002396_abnormal_hematopoietic_system1.49680391
65MP0001905_abnormal_dopamine_level1.49487948
66MP0003763_abnormal_thymus_physiology1.48388025
67MP0009745_abnormal_behavioral_response1.46411651
68MP0005253_abnormal_eye_physiology1.46305290
69MP0002419_abnormal_innate_immunity1.44145560
70MP0002282_abnormal_trachea_morphology1.44061424
71MP0001819_abnormal_immune_cell1.44010120
72MP0002734_abnormal_mechanical_nocicepti1.43888883
73MP0002420_abnormal_adaptive_immunity1.42847564
74MP0002751_abnormal_autonomic_nervous1.42684500
75MP0002723_abnormal_immune_serum1.41524479
76MP0000372_irregular_coat_pigmentation1.41035221
77MP0001293_anophthalmia1.39843793
78MP0002184_abnormal_innervation1.39296180
79MP0001485_abnormal_pinna_reflex1.39064263
80MP0001800_abnormal_humoral_immune1.38759265
81MP0002735_abnormal_chemical_nociception1.38173412
82MP0001853_heart_inflammation1.37596773
83MP0000015_abnormal_ear_pigmentation1.37489875
84MP0002234_abnormal_pharynx_morphology1.34706660
85MP0003635_abnormal_synaptic_transmissio1.33771406
86MP0009697_abnormal_copulation1.33319410
87MP0002557_abnormal_social/conspecific_i1.33182931
88MP0001486_abnormal_startle_reflex1.31748096
89MP0002752_abnormal_somatic_nervous1.30528753
90MP0005645_abnormal_hypothalamus_physiol1.30071696
91MP0003315_abnormal_perineum_morphology1.29306005
92MP0002405_respiratory_system_inflammati1.28931071
93MP0002572_abnormal_emotion/affect_behav1.27783928
94MP0005646_abnormal_pituitary_gland1.26801701
95MP0004808_abnormal_hematopoietic_stem1.26058838
96MP0001970_abnormal_pain_threshold1.25621267
97MP0008057_abnormal_DNA_replication1.24208140
98MP0002429_abnormal_blood_cell1.24082038
99MP0000689_abnormal_spleen_morphology1.22978088
100MP0000955_abnormal_spinal_cord1.22708721
101MP0002733_abnormal_thermal_nociception1.22294189
102MP0001879_abnormal_lymphatic_vessel1.21697564
103MP0002063_abnormal_learning/memory/cond1.21224841
104MP0000716_abnormal_immune_system1.21086757
105MP0003938_abnormal_ear_development1.20147631
106MP0002163_abnormal_gland_morphology1.19343746
107MP0002722_abnormal_immune_system1.18818712
108MP0004145_abnormal_muscle_electrophysio1.17280144
109MP0004811_abnormal_neuron_physiology1.16064949
110MP0003786_premature_aging1.16049772
111MP0003890_abnormal_embryonic-extraembry1.15333029
112MP0004270_analgesia1.14176614
113MP0002882_abnormal_neuron_morphology1.13520920
114MP0005195_abnormal_posterior_eye1.12920930
115MP0005503_abnormal_tendon_morphology1.12423918
116MP0004859_abnormal_synaptic_plasticity1.12025594
117MP0000343_altered_response_to1.09648279
118MP0002067_abnormal_sensory_capabilities1.09330108
119MP0000313_abnormal_cell_death1.08115704
120MP0002006_tumorigenesis1.06791448
121MP0002233_abnormal_nose_morphology1.05338194
122MP0002277_abnormal_respiratory_mucosa1.04853722
123MP0001790_abnormal_immune_system1.04645798
124MP0005387_immune_system_phenotype1.04645798
125MP0004885_abnormal_endolymph1.04315854
126MP0008789_abnormal_olfactory_epithelium1.04129367
127MP0002210_abnormal_sex_determination1.04052124
128MP0004742_abnormal_vestibular_system1.03826306
129MP0003136_yellow_coat_color1.02927887
130MP0002160_abnormal_reproductive_system1.01967947
131MP0006082_CNS_inflammation1.01634333
132MP0005075_abnormal_melanosome_morpholog0.99735261
133MP0002064_seizures0.99734178
134MP0000026_abnormal_inner_ear0.99631214
135MP0006035_abnormal_mitochondrial_morpho0.99420308
136MP0009278_abnormal_bone_marrow0.99381687
137MP0003119_abnormal_digestive_system0.98794026
138MP0005187_abnormal_penis_morphology0.97471571
139MP0002837_dystrophic_cardiac_calcinosis0.97271311
140MP0001986_abnormal_taste_sensitivity0.97016944
141MP0002095_abnormal_skin_pigmentation0.95543722
142MP0000703_abnormal_thymus_morphology0.95203588
143MP0002019_abnormal_tumor_incidence0.94694432
144MP0003448_altered_tumor_morphology0.93794650
145MP0000566_synostosis0.91826669
146MP0008438_abnormal_cutaneous_collagen0.91644824
147MP0003279_aneurysm0.91532760
148MP0001929_abnormal_gametogenesis0.91320595
149MP0002152_abnormal_brain_morphology0.89670289
150MP0003567_abnormal_fetal_cardiomyocyte0.89233565
151MP0001533_abnormal_skeleton_physiology0.88761139
152MP0005386_behavior/neurological_phenoty0.87702621
153MP0004924_abnormal_behavior0.87702621
154MP0005391_vision/eye_phenotype0.86953718
155MP0003937_abnormal_limbs/digits/tail_de0.86732688
156MP0002933_joint_inflammation0.86615084
157MP0003861_abnormal_nervous_system0.85747005
158MP0003698_abnormal_male_reproductive0.85640245
159MP0000350_abnormal_cell_proliferation0.84229179
160MP0010155_abnormal_intestine_physiology0.83413527
161MP0001845_abnormal_inflammatory_respons0.83160661
162MP0003123_paternal_imprinting0.83147135
163MP0009250_abnormal_appendicular_skeleto0.82868017
164MP0000767_abnormal_smooth_muscle0.82055301
165MP0001286_abnormal_eye_development0.81807562
166MP0000049_abnormal_middle_ear0.81725646
167MP0003718_maternal_effect0.81572268
168MP0008469_abnormal_protein_level0.81020035
169MP0009053_abnormal_anal_canal0.80119004
170MP0001963_abnormal_hearing_physiology0.79523170
171MP0005083_abnormal_biliary_tract0.79259888
172MP0002909_abnormal_adrenal_gland0.78637338
173MP0001440_abnormal_grooming_behavior0.78445298
174MP0005389_reproductive_system_phenotype0.78291361
175MP0002928_abnormal_bile_duct0.78077642
176MP0003942_abnormal_urinary_system0.77962458
177MP0005390_skeleton_phenotype0.77185286
178MP0009764_decreased_sensitivity_to0.75525454
179MP0003011_delayed_dark_adaptation0.74784206
180MP0001542_abnormal_bone_strength0.73983589
181MP0003646_muscle_fatigue0.73677660
182MP0005464_abnormal_platelet_physiology0.72329868
183MP0006036_abnormal_mitochondrial_physio0.71283882
184MP0001119_abnormal_female_reproductive0.71108624

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.68902281
2Abnormal number of erythroid precursors (HP:0012131)6.37217357
3Reticulocytopenia (HP:0001896)4.58496877
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.89906274
5Elevated erythrocyte sedimentation rate (HP:0003565)3.73470601
6Pallor (HP:0000980)3.67216038
7Acute necrotizing encephalopathy (HP:0006965)3.56828132
8Medial flaring of the eyebrow (HP:0010747)3.55147586
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50747328
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50747328
11Pancreatic fibrosis (HP:0100732)3.48651694
12Gait imbalance (HP:0002141)3.45384598
13Pancreatic cysts (HP:0001737)3.42284332
14Abnormality of midbrain morphology (HP:0002418)3.32160496
15Molar tooth sign on MRI (HP:0002419)3.32160496
16Abnormality of the labia minora (HP:0012880)3.29574708
17Congenital primary aphakia (HP:0007707)3.22076604
18Macrocytic anemia (HP:0001972)3.21604416
19Nephronophthisis (HP:0000090)3.15227490
20Mitochondrial inheritance (HP:0001427)3.14903718
21Abnormal mitochondria in muscle tissue (HP:0008316)3.13149958
22Nephrogenic diabetes insipidus (HP:0009806)3.12368366
23Aplastic anemia (HP:0001915)3.10558122
24Recurrent abscess formation (HP:0002722)3.09195735
253-Methylglutaconic aciduria (HP:0003535)2.95678989
26Polyphagia (HP:0002591)2.92865212
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89399182
28Myokymia (HP:0002411)2.79728861
29Exertional dyspnea (HP:0002875)2.79354924
30Hepatocellular necrosis (HP:0001404)2.77790888
31Poor head control (HP:0002421)2.76947043
32Lissencephaly (HP:0001339)2.72486063
33Progressive macrocephaly (HP:0004481)2.70783619
34Respiratory difficulties (HP:0002880)2.68535186
35Petechiae (HP:0000967)2.67369198
36Increased hepatocellular lipid droplets (HP:0006565)2.66419369
37Vaginal atresia (HP:0000148)2.64953558
38Genital tract atresia (HP:0001827)2.63152790
39Myositis (HP:0100614)2.62309710
40Cerebral edema (HP:0002181)2.57922499
41Hyperglycinemia (HP:0002154)2.57296298
42Increased CSF lactate (HP:0002490)2.56680692
43Retrobulbar optic neuritis (HP:0100654)2.55550222
44Optic neuritis (HP:0100653)2.55550222
45Limb dystonia (HP:0002451)2.49761971
46Anencephaly (HP:0002323)2.49687477
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48965163
48Birth length less than 3rd percentile (HP:0003561)2.48017651
49Multiple enchondromatosis (HP:0005701)2.46332340
50Cleft eyelid (HP:0000625)2.41721263
51Abnormality of the renal medulla (HP:0100957)2.40547377
52Sclerocornea (HP:0000647)2.39275704
53Recurrent bacterial skin infections (HP:0005406)2.38837240
54Acute encephalopathy (HP:0006846)2.37776610
55Type 2 muscle fiber atrophy (HP:0003554)2.37119786
56Retinal dysplasia (HP:0007973)2.35922180
57Muscle fiber atrophy (HP:0100295)2.33923888
58Pachygyria (HP:0001302)2.33873916
59Poor suck (HP:0002033)2.28756699
60Pendular nystagmus (HP:0012043)2.26721859
61Orchitis (HP:0100796)2.26604120
62Lipid accumulation in hepatocytes (HP:0006561)2.24673354
63Abolished electroretinogram (ERG) (HP:0000550)2.24124251
64Trismus (HP:0000211)2.21949712
65Abnormality of the anterior horn cell (HP:0006802)2.20541273
66Degeneration of anterior horn cells (HP:0002398)2.20541273
67Hepatic necrosis (HP:0002605)2.20350965
68IgM deficiency (HP:0002850)2.20286522
69Patellar aplasia (HP:0006443)2.19748294
70Septo-optic dysplasia (HP:0100842)2.18364620
71Postaxial foot polydactyly (HP:0001830)2.17744901
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17148294
73Renal Fanconi syndrome (HP:0001994)2.16170781
74Abnormality of renal resorption (HP:0011038)2.15032590
75Type I transferrin isoform profile (HP:0003642)2.14628824
76Increased serum lactate (HP:0002151)2.14526852
77Abnormality of reticulocytes (HP:0004312)2.14429067
78Agitation (HP:0000713)2.13009226
79Mediastinal lymphadenopathy (HP:0100721)2.10213687
80Increased IgM level (HP:0003496)2.08764882
81Short middle phalanx of the 5th finger (HP:0004220)2.08733238
82Specific learning disability (HP:0001328)2.08313414
83Oligodactyly (hands) (HP:0001180)2.08005302
84Oral leukoplakia (HP:0002745)2.06330864
85Poor coordination (HP:0002370)2.05579840
86Eczematoid dermatitis (HP:0000976)2.05068370
87Cortical dysplasia (HP:0002539)2.04988855
88Optic nerve hypoplasia (HP:0000609)2.04871572
89Aplasia/Hypoplasia of the patella (HP:0006498)2.04676676
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04616493
91Postaxial hand polydactyly (HP:0001162)2.04571568
92Optic nerve coloboma (HP:0000588)2.03533462
93Male pseudohermaphroditism (HP:0000037)2.03300760
94Cystic liver disease (HP:0006706)2.02090908
95Pulmonary artery stenosis (HP:0004415)2.01893638
96Exercise intolerance (HP:0003546)2.01230547
97Thrombocytosis (HP:0001894)2.01167962
98Type II lissencephaly (HP:0007260)1.99794876
99Congenital, generalized hypertrichosis (HP:0004540)1.99648857
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.99252834
101Chronic hepatic failure (HP:0100626)1.99108600
102Failure to thrive in infancy (HP:0001531)1.98930632
103Recurrent bronchitis (HP:0002837)1.97319720
104Drooling (HP:0002307)1.96937947
105Supernumerary spleens (HP:0009799)1.96815997
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96245489
107Nephroblastoma (Wilms tumor) (HP:0002667)1.95021037
108Abnormal lung lobation (HP:0002101)1.94876541
109Triphalangeal thumb (HP:0001199)1.94459304
110Abnormality of urine glucose concentration (HP:0011016)1.93343147
111Glycosuria (HP:0003076)1.93343147
112Occipital encephalocele (HP:0002085)1.93032910
113Absent/shortened dynein arms (HP:0200106)1.92489141
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.92489141
115Growth hormone deficiency (HP:0000824)1.92337017
116Embryonal renal neoplasm (HP:0011794)1.91572645
117Methylmalonic acidemia (HP:0002912)1.89786633
118Congenital stationary night blindness (HP:0007642)1.89771008
119Vasculitis (HP:0002633)1.89516894
120Metaphyseal dysplasia (HP:0100255)1.88677189
121Abnormal respiratory epithelium morphology (HP:0012253)1.88409142
122Abnormal respiratory motile cilium morphology (HP:0005938)1.88409142
123Renal cortical cysts (HP:0000803)1.88307438
124Narrow forehead (HP:0000341)1.87726107
125Preaxial hand polydactyly (HP:0001177)1.87128616
126Spastic tetraplegia (HP:0002510)1.83520747
127Decreased testicular size (HP:0008734)1.83429515
128Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83420643
129X-linked dominant inheritance (HP:0001423)1.83325073
130Stenosis of the external auditory canal (HP:0000402)1.83004936
131Broad-based gait (HP:0002136)1.82856072
132Abnormality of the corticospinal tract (HP:0002492)1.80570614
133Increased muscle lipid content (HP:0009058)1.80552186
134Thyroid-stimulating hormone excess (HP:0002925)1.80524894
135Abnormal rod and cone electroretinograms (HP:0008323)1.79379996
136Degeneration of the lateral corticospinal tracts (HP:0002314)1.78844118
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78844118
138Abnormal number of incisors (HP:0011064)1.78091797
139Anophthalmia (HP:0000528)1.77929266
140Methylmalonic aciduria (HP:0012120)1.77798809
141Recurrent sinusitis (HP:0011108)1.77207177
142Generalized aminoaciduria (HP:0002909)1.76396393
143True hermaphroditism (HP:0010459)1.76085899
144Adrenal hypoplasia (HP:0000835)1.75913116
145Intestinal atresia (HP:0011100)1.75171119
146Abnormal hair whorl (HP:0010721)1.74930282
147Excessive salivation (HP:0003781)1.74799182
148Amniotic constriction ring (HP:0009775)1.74571058
149Abnormality of placental membranes (HP:0011409)1.74571058
15011 pairs of ribs (HP:0000878)1.72295651
151Optic disc pallor (HP:0000543)1.69258221
152Recurrent pneumonia (HP:0006532)1.68031698
153Bicuspid aortic valve (HP:0001647)1.67792124
154Depressed nasal ridge (HP:0000457)1.66771335
155Respiratory failure (HP:0002878)1.66050397
156Basal ganglia calcification (HP:0002135)1.64938868
157Abnormality of the ileum (HP:0001549)1.64556152
158Cutaneous photosensitivity (HP:0000992)1.64327710
159Absent thumb (HP:0009777)1.63644661
160Meckel diverticulum (HP:0002245)1.63478830
161Lactic acidosis (HP:0003128)1.62064113
162Increased intramyocellular lipid droplets (HP:0012240)1.61780575
163Colon cancer (HP:0003003)1.60745344
164Chronic obstructive pulmonary disease (HP:0006510)1.59501658
165Obstructive lung disease (HP:0006536)1.59501658
166Pulmonary fibrosis (HP:0002206)1.58671895
167Microretrognathia (HP:0000308)1.58329597
168Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.57351810
169Lymphoma (HP:0002665)1.57082239
170Abnormality of glycolysis (HP:0004366)1.56444213
171Increased serum pyruvate (HP:0003542)1.56444213
172Recurrent lower respiratory tract infections (HP:0002783)1.55272878
173IgG deficiency (HP:0004315)1.54216613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.24632753
2TESK13.58240028
3TRIM282.96770032
4PIM22.91141299
5EIF2AK12.90500506
6MAP3K42.74286249
7STK162.72040856
8CASK2.71453922
9WNK32.70009704
10BUB12.67806055
11MAP2K72.54919275
12LIMK12.51958241
13TESK22.49446573
14BCR2.45287705
15MAP4K22.45096392
16ACVR1B2.43688879
17DYRK32.24614831
18PBK2.23293900
19DYRK22.06026845
20VRK12.03666195
21PINK11.92176472
22KDR1.89644741
23WEE11.88976604
24MINK11.83884112
25BLK1.79870175
26TXK1.75992152
27CSNK1G21.72589530
28BCKDK1.72263231
29NUAK11.69352935
30CSNK1G31.65107137
31TGFBR11.54754015
32TBK11.53207606
33SRPK11.48527497
34VRK21.44826149
35RPS6KA41.44357122
36MAP4K11.38351125
37CSNK1G11.36789918
38ILK1.36571537
39KIT1.36529834
40MYLK1.33959821
41MKNK11.33025282
42TLK11.31523155
43IKBKB1.30271940
44GRK11.29605733
45MAP3K141.28425428
46IRAK41.28399423
47CSNK1A1L1.25359497
48EPHA41.21812739
49PAK31.20764197
50PLK41.19188982
51YES11.19108709
52ZAK1.18505710
53EPHA31.16105754
54PRKCG1.15109286
55PLK21.13684142
56EIF2AK21.11398301
57BMPR1B1.10136895
58ERBB31.08792450
59MAP2K41.06903170
60FRK1.05700904
61MUSK1.02571204
62TAOK21.01295304
63IKBKE1.00730508
64EPHB21.00508144
65MST41.00113256
66MAP3K110.98585161
67CDC70.98571557
68MAPK130.97978443
69JAK30.97362575
70INSRR0.96743122
71CDK80.96023021
72TYK20.95739236
73NTRK20.94543441
74NEK20.92479224
75NME10.92131615
76PIM10.90220709
77MAP3K120.90107309
78PNCK0.89843360
79PLK30.89443782
80LRRK20.88126701
81ABL20.87314485
82CCNB10.86842450
83GRK70.85240314
84BTK0.84435102
85SIK20.84377295
86EIF2AK30.83293754
87AURKB0.81871184
88LYN0.78821675
89STK240.76138281
90CDK70.74554734
91DYRK1A0.74498705
92OXSR10.73798899
93ZAP700.71707863
94CHUK0.71066980
95AURKA0.70820952
96RPS6KA50.70446933
97CSNK2A10.70419204
98PAK40.69729598
99PHKG10.69177013
100PHKG20.69177013
101TEC0.67830283
102NTRK30.67586137
103TGFBR20.67243619
104PDK20.66730259
105ADRBK10.66710055
106PAK10.66096242
107BRAF0.65721066
108PLK10.65339577
109WNK40.63838645
110RPS6KB20.63130629
111BRSK20.62731499
112IRAK20.62215560
113MATK0.62071286
114ADRBK20.61507848
115SYK0.61370376
116PRKCE0.61240169
117NEK10.61165181
118MAP3K100.60825127
119CDK140.58627542
120ATR0.58493966
121TIE10.57573346
122PKN10.56537922
123UHMK10.54649974
124DAPK20.52709768
125OBSCN0.52595988
126MAP2K20.52399612
127PRKACA0.52321305
128TAOK30.51680797
129CDK50.51251105
130MARK10.51157215
131MAPK40.50193360
132CSNK1A10.48537558
133CAMK2A0.48190201
134STK40.47909889
135GRK50.46741737
136PDK40.46129736
137PDK30.46129736
138MKNK20.45521868
139RPS6KC10.45345819
140RPS6KL10.45345819
141IRAK30.45237330
142RPS6KA60.44943591
143LCK0.44631616
144PRKG20.43858484
145DYRK1B0.43501343
146CDK180.43310123
147CSNK2A20.43059650
148CSNK1E0.42441514
149CDK190.41154246
150BMPR20.41069963
151PASK0.40874485
152CAMK10.40819817
153SIK30.40789614
154PRKCD0.39974370
155ARAF0.39811349
156TNIK0.39731626
157PRKG10.37715275
158CDK11A0.37571325
159STK38L0.37544557
160CDK150.37168993
161PRKCZ0.34164669
162MAP3K60.33592029
163SGK4940.32025467
164SGK2230.32025467

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.97609400
2Proteasome_Homo sapiens_hsa030503.95310247
3DNA replication_Homo sapiens_hsa030303.33923420
4RNA polymerase_Homo sapiens_hsa030202.85266609
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63349487
6Mismatch repair_Homo sapiens_hsa034302.60245127
7Spliceosome_Homo sapiens_hsa030402.55956156
8Oxidative phosphorylation_Homo sapiens_hsa001902.45691218
9Parkinsons disease_Homo sapiens_hsa050122.43637616
10Base excision repair_Homo sapiens_hsa034102.37907829
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36746813
12Pyrimidine metabolism_Homo sapiens_hsa002402.30943695
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10122575
14Nucleotide excision repair_Homo sapiens_hsa034202.07526190
15Nicotine addiction_Homo sapiens_hsa050332.07317784
16Homologous recombination_Homo sapiens_hsa034402.06676132
17Huntingtons disease_Homo sapiens_hsa050161.99067809
18Graft-versus-host disease_Homo sapiens_hsa053321.88649482
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85149863
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84561825
21Phototransduction_Homo sapiens_hsa047441.83156204
22Basal transcription factors_Homo sapiens_hsa030221.74558818
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70697283
24Butanoate metabolism_Homo sapiens_hsa006501.64070562
25Protein export_Homo sapiens_hsa030601.62231289
26RNA transport_Homo sapiens_hsa030131.59017161
27Legionellosis_Homo sapiens_hsa051341.57794799
28Steroid biosynthesis_Homo sapiens_hsa001001.56072035
29Propanoate metabolism_Homo sapiens_hsa006401.54269421
30Collecting duct acid secretion_Homo sapiens_hsa049661.53981784
31Allograft rejection_Homo sapiens_hsa053301.50638485
32Alzheimers disease_Homo sapiens_hsa050101.50034367
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46765858
34RNA degradation_Homo sapiens_hsa030181.41478572
35Fanconi anemia pathway_Homo sapiens_hsa034601.39186532
36Cell cycle_Homo sapiens_hsa041101.38487519
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36481216
38Herpes simplex infection_Homo sapiens_hsa051681.29221121
39Leishmaniasis_Homo sapiens_hsa051401.26694517
40Fatty acid elongation_Homo sapiens_hsa000621.23857161
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22546605
42GABAergic synapse_Homo sapiens_hsa047271.22185185
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22159627
44Measles_Homo sapiens_hsa051621.17982241
45Regulation of autophagy_Homo sapiens_hsa041401.17759031
46Peroxisome_Homo sapiens_hsa041461.15334908
47Purine metabolism_Homo sapiens_hsa002301.13996027
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13726198
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12010090
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10626119
51Epstein-Barr virus infection_Homo sapiens_hsa051691.08942920
52Morphine addiction_Homo sapiens_hsa050321.05990946
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04507908
54Hematopoietic cell lineage_Homo sapiens_hsa046401.04117902
55Synaptic vesicle cycle_Homo sapiens_hsa047211.04039563
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03763766
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.03592061
58Non-homologous end-joining_Homo sapiens_hsa034501.02369907
59Antigen processing and presentation_Homo sapiens_hsa046121.01198748
60Malaria_Homo sapiens_hsa051441.00741470
61p53 signaling pathway_Homo sapiens_hsa041150.95975556
62Cardiac muscle contraction_Homo sapiens_hsa042600.95502487
63Primary immunodeficiency_Homo sapiens_hsa053400.94813609
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94513713
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91729304
66Linoleic acid metabolism_Homo sapiens_hsa005910.89211675
67Pertussis_Homo sapiens_hsa051330.88846625
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87299620
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87000434
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.86537063
71Asthma_Homo sapiens_hsa053100.86051527
72Dopaminergic synapse_Homo sapiens_hsa047280.85786610
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.85572604
74mRNA surveillance pathway_Homo sapiens_hsa030150.85403093
75Systemic lupus erythematosus_Homo sapiens_hsa053220.84122084
76Taste transduction_Homo sapiens_hsa047420.82916292
77Shigellosis_Homo sapiens_hsa051310.82778122
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82454038
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82397615
80Pyruvate metabolism_Homo sapiens_hsa006200.81689159
81Nitrogen metabolism_Homo sapiens_hsa009100.81159485
82Apoptosis_Homo sapiens_hsa042100.78903793
83Viral myocarditis_Homo sapiens_hsa054160.78406245
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78398706
85Influenza A_Homo sapiens_hsa051640.78028914
86One carbon pool by folate_Homo sapiens_hsa006700.77963037
87Tryptophan metabolism_Homo sapiens_hsa003800.77932074
88Sulfur relay system_Homo sapiens_hsa041220.75088247
89Circadian entrainment_Homo sapiens_hsa047130.74323145
90Glutamatergic synapse_Homo sapiens_hsa047240.74227748
91Olfactory transduction_Homo sapiens_hsa047400.73960283
92Salmonella infection_Homo sapiens_hsa051320.71262332
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70623196
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69087259
95Serotonergic synapse_Homo sapiens_hsa047260.68927591
96Autoimmune thyroid disease_Homo sapiens_hsa053200.68208570
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64967433
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64894801
99Rheumatoid arthritis_Homo sapiens_hsa053230.64738648
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.64458746
101Ether lipid metabolism_Homo sapiens_hsa005650.63953877
102Axon guidance_Homo sapiens_hsa043600.63709564
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62607184
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62254549
105Type I diabetes mellitus_Homo sapiens_hsa049400.61648873
106Hedgehog signaling pathway_Homo sapiens_hsa043400.60628333
107beta-Alanine metabolism_Homo sapiens_hsa004100.59960261
108Hepatitis B_Homo sapiens_hsa051610.59909477
109Cocaine addiction_Homo sapiens_hsa050300.59734981
110Arachidonic acid metabolism_Homo sapiens_hsa005900.59681641
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.59453097
112TNF signaling pathway_Homo sapiens_hsa046680.58974913
113Chemical carcinogenesis_Homo sapiens_hsa052040.56900379
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56668235
115HTLV-I infection_Homo sapiens_hsa051660.56540359
116Glutathione metabolism_Homo sapiens_hsa004800.55816058
117Tuberculosis_Homo sapiens_hsa051520.55779241
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54566995
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.54533018
120Alcoholism_Homo sapiens_hsa050340.53936865
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53827358
122Caffeine metabolism_Homo sapiens_hsa002320.51816349
123Phagosome_Homo sapiens_hsa041450.51742349
124Viral carcinogenesis_Homo sapiens_hsa052030.50941341
125Basal cell carcinoma_Homo sapiens_hsa052170.47890156
126Oocyte meiosis_Homo sapiens_hsa041140.47737298
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46405230
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45770511
129N-Glycan biosynthesis_Homo sapiens_hsa005100.44924894
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.44716329
131Osteoclast differentiation_Homo sapiens_hsa043800.44061665
132Selenocompound metabolism_Homo sapiens_hsa004500.43121046
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42659783
134Toxoplasmosis_Homo sapiens_hsa051450.42053605
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40604126
136Pentose phosphate pathway_Homo sapiens_hsa000300.40535870
137Colorectal cancer_Homo sapiens_hsa052100.40451990
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40264943
139Retinol metabolism_Homo sapiens_hsa008300.39604426
140T cell receptor signaling pathway_Homo sapiens_hsa046600.39287361
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39236609
142Fatty acid metabolism_Homo sapiens_hsa012120.39013768
143Insulin secretion_Homo sapiens_hsa049110.38704831
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35987363
145Sulfur metabolism_Homo sapiens_hsa009200.35696250
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35260729
147Staphylococcus aureus infection_Homo sapiens_hsa051500.35154802
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35146606
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33919580
150Folate biosynthesis_Homo sapiens_hsa007900.33881467
151TGF-beta signaling pathway_Homo sapiens_hsa043500.32985954
152Acute myeloid leukemia_Homo sapiens_hsa052210.32273001
153B cell receptor signaling pathway_Homo sapiens_hsa046620.31016884
154Small cell lung cancer_Homo sapiens_hsa052220.30216598
155Cholinergic synapse_Homo sapiens_hsa047250.29218748
156Amphetamine addiction_Homo sapiens_hsa050310.28608417
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24554913
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24511639
159Metabolic pathways_Homo sapiens_hsa011000.24068934
160Notch signaling pathway_Homo sapiens_hsa043300.23982526
161HIF-1 signaling pathway_Homo sapiens_hsa040660.22883439
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22689233

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