SVIL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.48308775
2cardiac myofibril assembly (GO:0055003)7.14246007
3actin-myosin filament sliding (GO:0033275)6.86212208
4muscle filament sliding (GO:0030049)6.86212208
5myofibril assembly (GO:0030239)6.57373569
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.94613763
7actin-mediated cell contraction (GO:0070252)5.83527667
8regulation of skeletal muscle contraction (GO:0014819)5.69480969
9plasma membrane repair (GO:0001778)5.50311824
10negative regulation of potassium ion transmembrane transport (GO:1901380)5.24936574
11cardiac muscle cell development (GO:0055013)5.19467092
12response to muscle activity (GO:0014850)5.08925047
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.06852943
14actomyosin structure organization (GO:0031032)5.05904548
15cardiac muscle contraction (GO:0060048)5.05258025
16cardiac cell development (GO:0055006)4.95590200
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.90948383
18carnitine shuttle (GO:0006853)4.89016080
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.78534395
20actin filament-based movement (GO:0030048)4.71027670
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.69972731
22regulation of relaxation of muscle (GO:1901077)4.66178773
23cardiac muscle tissue morphogenesis (GO:0055008)4.57595064
24cardiac muscle hypertrophy (GO:0003300)4.49559554
25fatty acid transmembrane transport (GO:1902001)4.45118625
26adult heart development (GO:0007512)4.38375957
27striated muscle contraction (GO:0006941)4.34972228
28striated muscle hypertrophy (GO:0014897)4.31212598
29regulation of actin filament-based movement (GO:1903115)4.29413330
30skeletal muscle fiber development (GO:0048741)4.26642694
31muscle tissue morphogenesis (GO:0060415)4.22351150
32sarcoplasmic reticulum calcium ion transport (GO:0070296)4.22223644
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.20220549
34ventricular cardiac muscle cell action potential (GO:0086005)4.16162940
35myotube cell development (GO:0014904)4.14583911
36regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.12759362
37heart trabecula formation (GO:0060347)4.08375220
38regulation of sarcomere organization (GO:0060297)4.06327339
39tricarboxylic acid cycle (GO:0006099)4.03829428
40muscle fiber development (GO:0048747)3.95895086
41regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.95789718
42muscle hypertrophy (GO:0014896)3.93799566
43regulation of striated muscle contraction (GO:0006942)3.68171447
44* skeletal muscle tissue development (GO:0007519)3.62008759
45glycogen catabolic process (GO:0005980)3.59627353
46regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57526092
47skeletal muscle contraction (GO:0003009)3.56041453
48muscle cell cellular homeostasis (GO:0046716)3.55769613
49carnitine transmembrane transport (GO:1902603)3.54405365
50skeletal muscle adaptation (GO:0043501)3.52286568
51response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.48251945
52regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47253272
53glucan catabolic process (GO:0009251)3.44591531
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44348789
55heart contraction (GO:0060047)3.42654685
56heart process (GO:0003015)3.42654685
57regulation of sequestering of triglyceride (GO:0010889)3.38485366
58regulation of myoblast differentiation (GO:0045661)3.36860569
59regulation of cell communication by electrical coupling (GO:0010649)3.36599032
60muscle cell fate commitment (GO:0042693)3.35323533
61regulation of the force of heart contraction (GO:0002026)3.33045831
62regulation of cardioblast differentiation (GO:0051890)3.29153795
63muscle organ development (GO:0007517)3.28375094
64muscle structure development (GO:0061061)3.28246024
65negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.28035226
66cellular polysaccharide catabolic process (GO:0044247)3.27433669
672-oxoglutarate metabolic process (GO:0006103)3.26233029
68regulation of fatty acid oxidation (GO:0046320)3.25358678
69regulation of muscle system process (GO:0090257)3.23351915
70regulation of calcium ion transmembrane transport (GO:1903169)3.21223301
71regulation of calcium ion transmembrane transporter activity (GO:1901019)3.21223301
72amino-acid betaine transport (GO:0015838)3.20924507
73carnitine transport (GO:0015879)3.20924507
74relaxation of muscle (GO:0090075)3.20476741
75striated muscle atrophy (GO:0014891)3.19721615
76striated muscle adaptation (GO:0014888)3.18601151
77muscle contraction (GO:0006936)3.17062918
78glycogen biosynthetic process (GO:0005978)3.14874504
79glucan biosynthetic process (GO:0009250)3.14874504
80striated muscle cell development (GO:0055002)3.13365179
81regulation of skeletal muscle cell differentiation (GO:2001014)3.12578502
82cardiac muscle adaptation (GO:0014887)3.12035927
83cardiac muscle hypertrophy in response to stress (GO:0014898)3.12035927
84muscle hypertrophy in response to stress (GO:0003299)3.12035927
85positive regulation of myoblast differentiation (GO:0045663)3.10633557
86negative regulation of striated muscle cell apoptotic process (GO:0010664)3.10237001
87cell communication involved in cardiac conduction (GO:0086065)3.10038668
88negative regulation of cardiac muscle tissue growth (GO:0055022)3.09791991
89negative regulation of heart growth (GO:0061117)3.09791991
90myoblast fusion (GO:0007520)3.08643529
91regulation of p38MAPK cascade (GO:1900744)3.07450251
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05963183
93NADH metabolic process (GO:0006734)3.04919895
94trabecula formation (GO:0060343)3.04917631
95response to epinephrine (GO:0071871)3.04850674
96skeletal muscle tissue regeneration (GO:0043403)3.04824754
97negative regulation of protein localization to cell surface (GO:2000009)3.02652976
98cellular response to epinephrine stimulus (GO:0071872)3.02053670
99muscle system process (GO:0003012)2.98390201
100creatine metabolic process (GO:0006600)2.92814694
101positive regulation of fatty acid oxidation (GO:0046321)2.92662318
102polysaccharide catabolic process (GO:0000272)2.92350727
103venous blood vessel morphogenesis (GO:0048845)2.91778479
104regulation of acyl-CoA biosynthetic process (GO:0050812)2.91461581
105* striated muscle tissue development (GO:0014706)2.90601755
106positive regulation of fatty acid beta-oxidation (GO:0032000)2.90601546
107relaxation of cardiac muscle (GO:0055119)2.88954684
108desmosome organization (GO:0002934)2.88551890
109regulation of skeletal muscle fiber development (GO:0048742)2.84807461
110syncytium formation by plasma membrane fusion (GO:0000768)2.84177582
111positive regulation of cation channel activity (GO:2001259)2.81216024
112regulation of myotube differentiation (GO:0010830)2.80067845
113vascular endothelial growth factor signaling pathway (GO:0038084)2.78492329
114muscle cell development (GO:0055001)2.76856960
115muscle adaptation (GO:0043500)2.76547313
116positive regulation of glycogen biosynthetic process (GO:0045725)2.76421103
117glycogen metabolic process (GO:0005977)2.76119735
118fatty acid beta-oxidation (GO:0006635)2.75549383
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.75500405
120regulation of cardiac muscle contraction (GO:0055117)2.75223978
121regulation of membrane repolarization (GO:0060306)2.72283536
122positive regulation of myotube differentiation (GO:0010831)2.72155166
123cardiac muscle cell action potential (GO:0086001)2.69639544
124intracellular lipid transport (GO:0032365)2.68751275
125regulation of heart rate (GO:0002027)2.68705344
126regulation of ATPase activity (GO:0043462)2.68346084
127regulation of ATP catabolic process (GO:1903289)2.68346084
128atrial septum morphogenesis (GO:0060413)2.66550684
129cardiac muscle cell action potential involved in contraction (GO:0086002)2.66234609
130response to inactivity (GO:0014854)2.65000490
131coronary vasculature morphogenesis (GO:0060977)2.64845314
132regulation of muscle contraction (GO:0006937)2.62872000
133epithelial cell-cell adhesion (GO:0090136)2.62118854
134regulation of cardiac muscle cell contraction (GO:0086004)2.61568892
135muscle atrophy (GO:0014889)2.61248764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.06753766
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.44331641
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.41269920
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10354701
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.07725895
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.07725895
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.03208464
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02111964
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92161602
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.82681957
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.79354035
12CLOCK_20551151_ChIP-Seq_293T_Human2.72110748
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.50503999
14* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.33911148
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30211235
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26801921
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.25166053
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21814003
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.16268018
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15630625
21MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.07168878
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.06619933
23ZNF263_19887448_ChIP-Seq_K562_Human1.89631653
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88858973
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85010002
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84605830
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83758058
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.81927350
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78276566
30* ESR2_21235772_ChIP-Seq_MCF-7_Human1.74025017
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71218693
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70153721
33GATA1_22025678_ChIP-Seq_K562_Human1.68600967
34NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.66911487
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63915371
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.63599213
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.61640731
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60605360
39GATA4_21415370_ChIP-Seq_HL-1_Mouse1.60216564
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59570061
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59496902
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59333176
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58275786
44* ESR1_21235772_ChIP-Seq_MCF-7_Human1.57900593
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56187552
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54536608
47EZH2_22144423_ChIP-Seq_EOC_Human1.52031964
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51409833
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49038162
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47397378
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.47038331
52TCF7_22412390_ChIP-Seq_EML_Mouse1.43419269
53* CJUN_26792858_Chip-Seq_BT549_Human1.43386685
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42209009
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41444951
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40097727
57KDM2B_26808549_Chip-Seq_DND41_Human1.40061973
58* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39756030
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36820185
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33924719
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29668525
62GATA1_19941826_ChIP-Seq_K562_Human1.24042269
63* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23829124
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.21765097
65* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21759943
66* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21759943
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.20889889
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20446851
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19504141
70ATF3_27146783_Chip-Seq_COLON_Human1.18514366
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18306328
72* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18224180
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17504918
74SPI1_23127762_ChIP-Seq_K562_Human1.15487522
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15473503
76* ISL1_27105846_Chip-Seq_CPCs_Mouse1.15285856
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15230363
78TP53_16413492_ChIP-PET_HCT116_Human1.13108068
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12883399
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.12376623
81* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10723271
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10539027
83GATA2_19941826_ChIP-Seq_K562_Human1.10444000
84* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09880550
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09697296
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09646466
87* BRD4_25478319_ChIP-Seq_HGPS_Human1.08951227
88* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08794689
89* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08457378
90* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07530306
91GBX2_23144817_ChIP-Seq_PC3_Human1.07515257
92MAF_26560356_Chip-Seq_TH1_Human1.06957321
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.06170180
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05627575
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05222089
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04861047
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04465130
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04228343
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.04216202
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03709924
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01470279
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01222099
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.01077354
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00337649
105AHR_22903824_ChIP-Seq_MCF-7_Human0.99722638
106RUNX_20019798_ChIP-Seq_JUKART_Human0.99508781
107* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98547254
108DROSHA_22980978_ChIP-Seq_HELA_Human0.97853634
109VDR_24787735_ChIP-Seq_THP-1_Human0.96118864
110* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96025488
111LXR_22292898_ChIP-Seq_THP-1_Human0.96011837
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95987096
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95622736
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95300568
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95091198
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93895149
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92700431
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92700431
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92167775
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.91417824
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.90776396
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.90410804
123AR_21572438_ChIP-Seq_LNCaP_Human0.90186574
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88111805
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85942700
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85720745
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84655795
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.82822245
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81890860
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81397198
131* GATA1_19941827_ChIP-Seq_MEL_Mouse0.81180106
132* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80532125
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80179332
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80179332
135* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79912602
136* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79450224
137TP63_23658742_ChIP-Seq_EP156T_Human0.79173002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.24556868
2MP0004084_abnormal_cardiac_muscle4.53216444
3MP0000751_myopathy4.17652680
4MP0003646_muscle_fatigue3.70263259
5MP0000749_muscle_degeneration3.52061489
6MP0004036_abnormal_muscle_relaxation3.40945465
7MP0004215_abnormal_myocardial_fiber3.40387264
8MP0005330_cardiomyopathy3.15209723
9MP0004087_abnormal_muscle_fiber2.87058331
10MP0000750_abnormal_muscle_regeneration2.56994595
11MP0002972_abnormal_cardiac_muscle2.52347678
12MP0010630_abnormal_cardiac_muscle2.49764964
13MP0004130_abnormal_muscle_cell2.45478081
14MP0008775_abnormal_heart_ventricle2.44969653
15MP0008438_abnormal_cutaneous_collagen2.44445982
16MP0003828_pulmonary_edema2.41344830
17MP0005620_abnormal_muscle_contractility2.32654020
18MP0002106_abnormal_muscle_physiology2.32421615
19MP0004145_abnormal_muscle_electrophysio2.24562974
20MP0001544_abnormal_cardiovascular_syste2.15635616
21MP0005385_cardiovascular_system_phenoty2.15635616
22MP0003705_abnormal_hypodermis_morpholog2.08357452
23MP0002269_muscular_atrophy1.98273261
24MP0004510_myositis1.92765691
25MP0005369_muscle_phenotype1.92628892
26MP0000759_abnormal_skeletal_muscle1.88674289
27MP0006138_congestive_heart_failure1.88539646
28MP0003137_abnormal_impulse_conducting1.87795308
29MP0003279_aneurysm1.84268459
30MP0010368_abnormal_lymphatic_system1.83617267
31MP0004484_altered_response_of1.82388551
32MP0005275_abnormal_skin_tensile1.81424402
33MP0000747_muscle_weakness1.71796958
34MP0003566_abnormal_cell_adhesion1.62931650
35MP0003950_abnormal_plasma_membrane1.54290574
36MP0003221_abnormal_cardiomyocyte_apopto1.48144407
37MP0000733_abnormal_muscle_development1.46131568
38MP0005666_abnormal_adipose_tissue1.45930362
39MP0002127_abnormal_cardiovascular_syste1.45643092
40MP0005670_abnormal_white_adipose1.43896692
41MP0004272_abnormal_basement_membrane1.41639561
42MP0003567_abnormal_fetal_cardiomyocyte1.40261277
43MP0004085_abnormal_heartbeat1.37320210
44MP0000343_altered_response_to1.29534825
45MP0004233_abnormal_muscle_weight1.28715001
46MP0001661_extended_life_span1.28370952
47MP0001879_abnormal_lymphatic_vessel1.26217126
48MP0002108_abnormal_muscle_morphology1.22618995
49MP0000266_abnormal_heart_morphology1.21947963
50MP0005503_abnormal_tendon_morphology1.21227071
51MP0000767_abnormal_smooth_muscle1.20062518
52MP0004185_abnormal_adipocyte_glucose1.19743222
53MP0001958_emphysema1.16540290
54MP0002128_abnormal_blood_circulation1.07440734
55MP0005375_adipose_tissue_phenotype1.07247376
56MP0002332_abnormal_exercise_endurance1.05942368
57MP0006054_spinal_hemorrhage0.97875022
58MP0003045_fibrosis0.92260145
59MP0009780_abnormal_chondrocyte_physiolo0.90320858
60MP0006036_abnormal_mitochondrial_physio0.83490862
61MP0009384_cardiac_valve_regurgitation0.82641146
62MP0002925_abnormal_cardiovascular_devel0.81820488
63MP0009278_abnormal_bone_marrow0.80699509
64MP0005165_increased_susceptibility_to0.79316655
65MP0003300_gastrointestinal_ulcer0.77768532
66MP0002234_abnormal_pharynx_morphology0.76215317
67MP0008961_abnormal_basal_metabolism0.75610484
68MP0002971_abnormal_brown_adipose0.74556288
69MP0010030_abnormal_orbit_morphology0.74113571
70MP0005623_abnormal_meninges_morphology0.72924709
71MP0003252_abnormal_bile_duct0.72276444
72MP0001299_abnormal_eye_distance/0.72049074
73MP0005023_abnormal_wound_healing0.71427897
74MP0001614_abnormal_blood_vessel0.69939381
75MP0002060_abnormal_skin_morphology0.69265575
76MP0000003_abnormal_adipose_tissue0.68783193
77MP0002877_abnormal_melanocyte_morpholog0.68272950
78MP0005076_abnormal_cell_differentiation0.64250702
79MP0000762_abnormal_tongue_morphology0.63599956
80MP0005409_darkened_coat_color0.60948203
81MP0010352_gastrointestinal_tract_polyps0.60282105
82MP0005319_abnormal_enzyme/_coenzyme0.59859128
83MP0005595_abnormal_vascular_smooth0.56068102
84MP0002166_altered_tumor_susceptibility0.54973990
85MP0002088_abnormal_embryonic_growth/wei0.54426802
86MP0003984_embryonic_growth_retardation0.53760241
87MP0003091_abnormal_cell_migration0.51917674
88MP0009115_abnormal_fat_cell0.51280586
89MP0001784_abnormal_fluid_regulation0.51235084
90MP0000230_abnormal_systemic_arterial0.51114498
91MP0002168_other_aberrant_phenotype0.50301174
92MP0000249_abnormal_blood_vessel0.49993301
93MP0003941_abnormal_skin_development0.49647491
94MP0000013_abnormal_adipose_tissue0.48805442
95MP0002896_abnormal_bone_mineralization0.47387133
96MP0005334_abnormal_fat_pad0.47108030
97MP0004808_abnormal_hematopoietic_stem0.46882972
98MP0001853_heart_inflammation0.46645780
99MP0004858_abnormal_nervous_system0.45376276
100MP0005085_abnormal_gallbladder_physiolo0.45103723
101MP0003191_abnormal_cellular_cholesterol0.44421817
102MP0009250_abnormal_appendicular_skeleto0.44309697
103MP0002933_joint_inflammation0.43961524
104MP0001175_abnormal_lung_morphology0.43928217
105MP0005083_abnormal_biliary_tract0.43441562
106MP0005451_abnormal_body_composition0.43211974
107MP0002133_abnormal_respiratory_system0.43204980
108MP0005388_respiratory_system_phenotype0.43204980
109MP0005266_abnormal_metabolism0.42145247
110MP0003385_abnormal_body_wall0.42057749
111MP0004270_analgesia0.40515142
112MP0000534_abnormal_ureter_morphology0.40390034
113MP0008004_abnormal_stomach_pH0.39637597
114MP0001849_ear_inflammation0.39237019
115MP0002114_abnormal_axial_skeleton0.39004621
116MP0004134_abnormal_chest_morphology0.38250744
117MP0000462_abnormal_digestive_system0.38069494
118MP0005166_decreased_susceptibility_to0.38045601
119MP0003656_abnormal_erythrocyte_physiolo0.36370280
120MP0005248_abnormal_Harderian_gland0.35307953
121MP0003948_abnormal_gas_homeostasis0.33926681
122MP0000579_abnormal_nail_morphology0.33097226
123MP0002998_abnormal_bone_remodeling0.31159871
124MP0005376_homeostasis/metabolism_phenot0.29695414

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.75836217
2Ventricular tachycardia (HP:0004756)5.83879564
3Muscle fiber splitting (HP:0003555)5.39140152
4Exercise-induced muscle cramps (HP:0003710)5.38714136
5Calf muscle hypertrophy (HP:0008981)5.34047855
6Exercise-induced myalgia (HP:0003738)5.20143269
7Right ventricular cardiomyopathy (HP:0011663)5.17908331
8Type 1 muscle fiber predominance (HP:0003803)4.95612685
9Hyporeflexia of lower limbs (HP:0002600)4.94495684
10Muscle hypertrophy of the lower extremities (HP:0008968)4.92747702
11Increased connective tissue (HP:0009025)4.84033505
12Subaortic stenosis (HP:0001682)4.78493426
13Abnormality of the left ventricular outflow tract (HP:0011103)4.78493426
14Lipoatrophy (HP:0100578)4.73314332
15Abnormality of the calf musculature (HP:0001430)4.69022139
16Atrial fibrillation (HP:0005110)4.60765811
17Primary atrial arrhythmia (HP:0001692)4.24569493
18Myoglobinuria (HP:0002913)4.10793472
19Supraventricular tachycardia (HP:0004755)4.05774245
20Supraventricular arrhythmia (HP:0005115)4.03388548
21EMG: myopathic abnormalities (HP:0003458)4.00865607
22Muscle fiber inclusion bodies (HP:0100299)3.86189093
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.86031058
24Dilated cardiomyopathy (HP:0001644)3.79499255
25Asymmetric septal hypertrophy (HP:0001670)3.76808726
26Difficulty running (HP:0009046)3.60568774
27Syncope (HP:0001279)3.52755712
28Calcaneovalgus deformity (HP:0001848)3.41138444
29Ventricular arrhythmia (HP:0004308)3.26792140
30Rhabdomyolysis (HP:0003201)3.20548824
31Palpitations (HP:0001962)3.19953085
32Bundle branch block (HP:0011710)3.17997986
33Nemaline bodies (HP:0003798)3.15601201
34Broad metatarsal (HP:0001783)3.08725935
35Increased variability in muscle fiber diameter (HP:0003557)3.05708460
36Deformed tarsal bones (HP:0008119)3.03784740
37Prolonged QT interval (HP:0001657)3.03086445
38Mildly elevated creatine phosphokinase (HP:0008180)3.00965079
39Abnormality of skeletal muscle fiber size (HP:0012084)2.99287227
40Absent phalangeal crease (HP:0006109)2.91701078
41Difficulty climbing stairs (HP:0003551)2.88611703
42Atrioventricular block (HP:0001678)2.83224083
43Heart block (HP:0012722)2.78253714
44Myotonia (HP:0002486)2.77899289
45Malignant hyperthermia (HP:0002047)2.74676174
46Abnormal atrioventricular conduction (HP:0005150)2.71842667
47Distal arthrogryposis (HP:0005684)2.65508031
48Bulbar palsy (HP:0001283)2.64880487
49Round ear (HP:0100830)2.60105539
50Hypoplastic ischia (HP:0003175)2.57055691
51Cerebral aneurysm (HP:0004944)2.56445322
52Protrusio acetabuli (HP:0003179)2.50426429
53Hypoglycemic coma (HP:0001325)2.49915753
54Distal lower limb muscle weakness (HP:0009053)2.49637660
55Ankle contracture (HP:0006466)2.46191957
56Neck muscle weakness (HP:0000467)2.45566605
57Abnormal finger flexion creases (HP:0006143)2.44227623
58Facial diplegia (HP:0001349)2.38943024
59Scapular winging (HP:0003691)2.34759482
60Abnormality of the calcaneus (HP:0008364)2.30083656
61Spinal rigidity (HP:0003306)2.30020776
62Abnormality of the ischium (HP:0003174)2.27606814
63Abnormality of the foot musculature (HP:0001436)2.27388403
64Muscle stiffness (HP:0003552)2.22413671
65Distal lower limb amyotrophy (HP:0008944)2.20328738
66Aortic aneurysm (HP:0004942)2.17523817
67Ventricular fibrillation (HP:0001663)2.17447121
68Foot dorsiflexor weakness (HP:0009027)2.15568437
69Aneurysm (HP:0002617)2.15467827
70Ketoacidosis (HP:0001993)2.13644603
71Fatigable weakness (HP:0003473)2.12960378
72Abnormality of the neuromuscular junction (HP:0003398)2.12960378
73Generalized muscle weakness (HP:0003324)2.12417936
74Palmoplantar keratoderma (HP:0000982)2.12393385
75Lower limb amyotrophy (HP:0007210)2.10166415
76Limited hip movement (HP:0008800)2.09804878
77Hyperkalemia (HP:0002153)2.08793432
78Areflexia of lower limbs (HP:0002522)2.08404811
79Abnormality of the shoulder girdle musculature (HP:0001435)2.07155176
80Weak cry (HP:0001612)2.04964605
81Fetal akinesia sequence (HP:0001989)2.04763512
82Frequent falls (HP:0002359)2.03886116
83Lymphangioma (HP:0100764)2.03288123
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.03116364
85Myopathic facies (HP:0002058)2.02336395
86EMG: neuropathic changes (HP:0003445)2.01516521
87Ulnar deviation of the wrist (HP:0003049)2.01237509
88Popliteal pterygium (HP:0009756)1.99737895
89Sudden cardiac death (HP:0001645)1.99151692
90Waddling gait (HP:0002515)1.98193848
91Aortic dissection (HP:0002647)1.97674178
92Hip contracture (HP:0003273)1.96912803
93Limb-girdle muscle atrophy (HP:0003797)1.96562062
94Abnormal EKG (HP:0003115)1.94883600
95Conjunctival hamartoma (HP:0100780)1.90057526
96Premature rupture of membranes (HP:0001788)1.87719656
97Slender build (HP:0001533)1.87501646
98Muscular dystrophy (HP:0003560)1.87350040
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85849124
100Left ventricular hypertrophy (HP:0001712)1.84989499
101Pulmonary artery stenosis (HP:0004415)1.83489827
102Steppage gait (HP:0003376)1.79050765
103Congestive heart failure (HP:0001635)1.77202758
104Rimmed vacuoles (HP:0003805)1.76727167
105Abnormality of fatty-acid metabolism (HP:0004359)1.74880252
106Hyperglycemia (HP:0003074)1.72424784
107Proximal amyotrophy (HP:0007126)1.69060500
108Gowers sign (HP:0003391)1.68972003
109Atrophic scars (HP:0001075)1.67950062
110Rectal prolapse (HP:0002035)1.66785710
111Testicular atrophy (HP:0000029)1.65474400
112Generalized amyotrophy (HP:0003700)1.64671750
113Shallow orbits (HP:0000586)1.63529623
114Respiratory insufficiency due to muscle weakness (HP:0002747)1.63516386
115Limb-girdle muscle weakness (HP:0003325)1.60414500
116Metatarsus adductus (HP:0001840)1.60044122
117Hypoalphalipoproteinemia (HP:0003233)1.57813488
118Ketosis (HP:0001946)1.57507701
119Neonatal death (HP:0003811)1.56773371
120Hamartoma of the eye (HP:0010568)1.56454492
121Mitral valve prolapse (HP:0001634)1.54998634
122Long clavicles (HP:0000890)1.54646337
123Hyperinsulinemic hypoglycemia (HP:0000825)1.54481225
124Progressive muscle weakness (HP:0003323)1.54068876
125Ulnar deviation of finger (HP:0009465)1.53042607
126Abnormality of the hip-girdle musculature (HP:0001445)1.47450211
127Abnormality of the musculature of the pelvis (HP:0001469)1.47450211
128Ragged-red muscle fibers (HP:0003200)1.45984885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.49685453
2OBSCN4.88412119
3TRIB33.59185660
4PKN23.39373917
5DMPK3.03744543
6MYLK2.78740592
7PHKG12.29462951
8PHKG22.29462951
9LMTK22.21078205
10TIE12.18477040
11PIK3CA1.97362195
12RIPK11.83764200
13TGFBR21.77377973
14STK241.72286748
15PDK31.69579890
16PDK41.69579890
17SIK11.68485355
18LATS11.59916191
19PDGFRA1.51882824
20ZAK1.47310388
21ERN11.41878791
22INSRR1.37431085
23MAP2K31.36205849
24MAP3K101.35241979
25PTK61.34624373
26TRPM71.34136523
27EPHB11.33741288
28BCKDK1.33721594
29MAP3K71.32667366
30FGFR41.27008717
31PIK3CG1.17618845
32FLT31.13271083
33NEK11.12613484
34ILK1.11708207
35NEK91.11617818
36MUSK1.06249806
37MAP3K31.04674133
38PDK21.00538383
39PRKD10.99852258
40PRKAA20.98179504
41CAMK1D0.98119964
42MAPK70.97653506
43EPHA30.94529568
44LRRK20.88718731
45FGFR30.87875028
46MAP3K60.87226535
47STK40.86887758
48MOS0.86581350
49KDR0.86406966
50CDK120.84530129
51LIMK10.82646598
52EEF2K0.76505861
53ROCK10.76255110
54JAK10.74119689
55STK30.73356408
56MAPK120.72998337
57MTOR0.72093639
58CAMK1G0.70140819
59CDC42BPA0.70115071
60STK100.69738651
61PDGFRB0.69638041
62LATS20.69411192
63MAP2K40.68643554
64CAMK2G0.68326330
65PRKAA10.68207530
66PAK30.64203073
67MARK20.64131655
68KSR20.62659804
69SGK20.61987212
70PINK10.61049875
71MAP2K60.60235673
72MAPKAPK30.58435719
73NLK0.56108924
74MAP3K130.56091923
75MAP3K50.54887787
76FGFR20.54841480
77MAPK40.53734197
78EPHB20.53659557
79MET0.53543900
80MAP3K10.53536151
81ZAP700.51606986
82CAMK2D0.51598974
83RPS6KC10.51376714
84RPS6KL10.51376714
85PAK20.51338040
86CAMK10.51237836
87TYK20.50207673
88MAP2K10.49314987
89RPS6KA60.48969646
90ERBB30.48940036
91GRK70.48080081
92AKT30.47249812
93PTK20.47034936
94CSK0.46867169
95MARK10.46823748
96MST1R0.46721242
97CAMK40.46131876
98JAK30.44637492
99STK38L0.44617949
100DYRK1B0.44570785
101WNK10.44437828
102RPS6KA20.44389234
103TGFBR10.43903008
104FGFR10.43629175
105TBK10.42751941
106RET0.41224425
107PRKG10.41152696
108PAK40.40883813
109MARK30.40738629
110JAK20.40639704
111MAP4K10.40316354
112MAPK110.39773217
113PTK2B0.39310208
114DDR20.38962121
115CDK60.38572161
116FER0.38523739
117PRKCH0.36930978
118ITK0.36927094
119DAPK30.36135950
120ICK0.35854444
121CHUK0.35509891
122ROCK20.35101472
123AKT20.34848417
124STK380.34688981
125KSR10.34412434
126SGK2230.31926862
127SGK4940.31926862
128SGK30.31609982
129FRK0.29310401
130EPHA20.29221883
131NUAK10.28664161
132BMX0.28375785
133PRKG20.27961736
134CAMK2A0.27466253
135TAOK20.24538557
136PDPK10.23586332
137CAMK2B0.23247378
138RAF10.23019814
139GSK3A0.22005321

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.30240136
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.81064404
3Dilated cardiomyopathy_Homo sapiens_hsa054143.67088240
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.21640584
5Fatty acid degradation_Homo sapiens_hsa000712.88606401
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.77534403
7Propanoate metabolism_Homo sapiens_hsa006402.56043789
8Cardiac muscle contraction_Homo sapiens_hsa042602.54279391
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.45260366
10Viral myocarditis_Homo sapiens_hsa054162.19630943
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99418239
12Fatty acid metabolism_Homo sapiens_hsa012121.99286166
13Carbon metabolism_Homo sapiens_hsa012001.84835932
14Insulin resistance_Homo sapiens_hsa049311.82044578
15Focal adhesion_Homo sapiens_hsa045101.69759718
16ECM-receptor interaction_Homo sapiens_hsa045121.69454963
17Lysine degradation_Homo sapiens_hsa003101.63778604
18Starch and sucrose metabolism_Homo sapiens_hsa005001.59597178
19PPAR signaling pathway_Homo sapiens_hsa033201.50469259
20Calcium signaling pathway_Homo sapiens_hsa040201.42280586
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.40552779
22Adherens junction_Homo sapiens_hsa045201.36089750
23Renin secretion_Homo sapiens_hsa049241.26482107
24Tryptophan metabolism_Homo sapiens_hsa003801.18733224
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16482914
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15873407
27Insulin signaling pathway_Homo sapiens_hsa049101.15132926
28Amoebiasis_Homo sapiens_hsa051461.14421084
29Pyruvate metabolism_Homo sapiens_hsa006201.13837889
30GnRH signaling pathway_Homo sapiens_hsa049121.12049384
31Pentose phosphate pathway_Homo sapiens_hsa000301.11894309
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10430696
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.08902829
34Small cell lung cancer_Homo sapiens_hsa052221.06198974
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04839690
36Proteoglycans in cancer_Homo sapiens_hsa052051.04224397
37AMPK signaling pathway_Homo sapiens_hsa041521.03055907
38Glucagon signaling pathway_Homo sapiens_hsa049221.00460356
39Gastric acid secretion_Homo sapiens_hsa049710.97886281
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97813179
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96369768
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92322678
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90368894
44Toxoplasmosis_Homo sapiens_hsa051450.89505762
45beta-Alanine metabolism_Homo sapiens_hsa004100.87219889
46HIF-1 signaling pathway_Homo sapiens_hsa040660.86618245
47Arginine biosynthesis_Homo sapiens_hsa002200.85250142
48Caffeine metabolism_Homo sapiens_hsa002320.84021806
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.79766176
50Tight junction_Homo sapiens_hsa045300.79732486
51Endometrial cancer_Homo sapiens_hsa052130.79626146
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78768321
53Platelet activation_Homo sapiens_hsa046110.77658014
54Staphylococcus aureus infection_Homo sapiens_hsa051500.72260336
55Fatty acid biosynthesis_Homo sapiens_hsa000610.71997944
56Biosynthesis of amino acids_Homo sapiens_hsa012300.71793464
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71108467
58Galactose metabolism_Homo sapiens_hsa000520.70935088
59Leishmaniasis_Homo sapiens_hsa051400.70310443
60Protein digestion and absorption_Homo sapiens_hsa049740.69801551
61Glioma_Homo sapiens_hsa052140.69741213
62Type II diabetes mellitus_Homo sapiens_hsa049300.69556313
63Butanoate metabolism_Homo sapiens_hsa006500.68077091
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67390255
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67033327
66Chronic myeloid leukemia_Homo sapiens_hsa052200.66192558
67Complement and coagulation cascades_Homo sapiens_hsa046100.65891916
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65215414
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64531245
70Long-term potentiation_Homo sapiens_hsa047200.63150237
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61863238
72Notch signaling pathway_Homo sapiens_hsa043300.61275100
73Non-small cell lung cancer_Homo sapiens_hsa052230.60385381
74cAMP signaling pathway_Homo sapiens_hsa040240.59960884
75MAPK signaling pathway_Homo sapiens_hsa040100.59315929
76Melanogenesis_Homo sapiens_hsa049160.59033158
77Thyroid cancer_Homo sapiens_hsa052160.58289666
78Phenylalanine metabolism_Homo sapiens_hsa003600.57317250
79Osteoclast differentiation_Homo sapiens_hsa043800.57273969
80Salivary secretion_Homo sapiens_hsa049700.56310320
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55599750
82Parkinsons disease_Homo sapiens_hsa050120.55410948
83Acute myeloid leukemia_Homo sapiens_hsa052210.55385701
84ABC transporters_Homo sapiens_hsa020100.55083924
85Fat digestion and absorption_Homo sapiens_hsa049750.52840014
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.52559704
87mTOR signaling pathway_Homo sapiens_hsa041500.51242005
88Gap junction_Homo sapiens_hsa045400.50863381
89MicroRNAs in cancer_Homo sapiens_hsa052060.50408330
90Peroxisome_Homo sapiens_hsa041460.50176643
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.49866259
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49655852
93FoxO signaling pathway_Homo sapiens_hsa040680.49448890
94Malaria_Homo sapiens_hsa051440.48936996
95Pancreatic secretion_Homo sapiens_hsa049720.48338154
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.48233412
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47846574
98Ovarian steroidogenesis_Homo sapiens_hsa049130.46733123
99Fatty acid elongation_Homo sapiens_hsa000620.45665700
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44671692
101Alzheimers disease_Homo sapiens_hsa050100.44653862
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44160233
103Estrogen signaling pathway_Homo sapiens_hsa049150.43220829
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42030287
105Circadian entrainment_Homo sapiens_hsa047130.41858778
106Legionellosis_Homo sapiens_hsa051340.41396315
107Choline metabolism in cancer_Homo sapiens_hsa052310.40047018
108ErbB signaling pathway_Homo sapiens_hsa040120.39943828
109Prostate cancer_Homo sapiens_hsa052150.39303791
110Cholinergic synapse_Homo sapiens_hsa047250.39203724
111Long-term depression_Homo sapiens_hsa047300.38215323
112Axon guidance_Homo sapiens_hsa043600.37921562
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36976295
114Inositol phosphate metabolism_Homo sapiens_hsa005620.36418386
115Prolactin signaling pathway_Homo sapiens_hsa049170.36286757
116TNF signaling pathway_Homo sapiens_hsa046680.35369068
117Pathways in cancer_Homo sapiens_hsa052000.35175985
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.34278036
119Bladder cancer_Homo sapiens_hsa052190.33435328
120Arginine and proline metabolism_Homo sapiens_hsa003300.32478798
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.31491411
122Circadian rhythm_Homo sapiens_hsa047100.30722684
123Oxytocin signaling pathway_Homo sapiens_hsa049210.30159006
124HTLV-I infection_Homo sapiens_hsa051660.29663802
125Bile secretion_Homo sapiens_hsa049760.28782264
126Pancreatic cancer_Homo sapiens_hsa052120.28411239
127Dorso-ventral axis formation_Homo sapiens_hsa043200.27384129
128TGF-beta signaling pathway_Homo sapiens_hsa043500.26149431
129Renal cell carcinoma_Homo sapiens_hsa052110.25872529
130Fructose and mannose metabolism_Homo sapiens_hsa000510.25531670
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25389300
132Salmonella infection_Homo sapiens_hsa051320.24611305
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.24098919
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23545257
135VEGF signaling pathway_Homo sapiens_hsa043700.23333816

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