SVILP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.29688238
2actin-mediated cell contraction (GO:0070252)8.44401098
3regulation of skeletal muscle contraction (GO:0014819)7.82704010
4skeletal muscle contraction (GO:0003009)7.53299392
5response to muscle activity (GO:0014850)7.44411455
6regulation of relaxation of muscle (GO:1901077)7.07887189
7myofibril assembly (GO:0030239)6.80787882
8sarcomere organization (GO:0045214)6.44062963
9actin filament-based movement (GO:0030048)6.36055016
10striated muscle contraction (GO:0006941)5.61323917
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.52767190
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.40142691
13skeletal muscle fiber development (GO:0048741)5.19944031
14skeletal muscle adaptation (GO:0043501)5.04425693
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.03054835
16creatine metabolic process (GO:0006600)4.98875433
17response to inactivity (GO:0014854)4.87387602
18cytidine deamination (GO:0009972)4.86501966
19cytidine metabolic process (GO:0046087)4.86501966
20cytidine catabolic process (GO:0006216)4.86501966
21plasma membrane repair (GO:0001778)4.83194416
22cardiac myofibril assembly (GO:0055003)4.77783141
23muscle contraction (GO:0006936)4.75436363
24myotube cell development (GO:0014904)4.72302144
25pyrimidine ribonucleoside catabolic process (GO:0046133)4.62852623
26actomyosin structure organization (GO:0031032)4.43099967
27muscle system process (GO:0003012)4.34614136
28muscle fiber development (GO:0048747)4.27992765
29glycogen catabolic process (GO:0005980)4.10701944
30cardiac muscle hypertrophy (GO:0003300)4.08582543
31regulation of gamma-delta T cell differentiation (GO:0045586)4.06973576
32cardiac muscle contraction (GO:0060048)4.00006032
33muscle cell cellular homeostasis (GO:0046716)3.99408439
34glucan catabolic process (GO:0009251)3.98148424
35skeletal muscle tissue development (GO:0007519)3.94363215
36regulation of actin filament-based movement (GO:1903115)3.89383762
37striated muscle hypertrophy (GO:0014897)3.88258342
38regulation of cell communication by electrical coupling (GO:0010649)3.85460978
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.75305999
40striated muscle adaptation (GO:0014888)3.75285034
41cellular polysaccharide catabolic process (GO:0044247)3.73797493
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.72718185
43response to activity (GO:0014823)3.66321553
44negative regulation of T cell apoptotic process (GO:0070233)3.65423543
45regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.63186828
46muscle hypertrophy (GO:0014896)3.58121788
47striated muscle atrophy (GO:0014891)3.57319779
48regulation of myoblast differentiation (GO:0045661)3.55820901
49regulation of gamma-delta T cell activation (GO:0046643)3.48968551
50muscle cell fate commitment (GO:0042693)3.46728346
51regulation of platelet aggregation (GO:0090330)3.41706450
52polysaccharide catabolic process (GO:0000272)3.38216858
53AMP metabolic process (GO:0046033)3.37686201
54glucan biosynthetic process (GO:0009250)3.37521769
55glycogen biosynthetic process (GO:0005978)3.37521769
56skeletal muscle tissue regeneration (GO:0043403)3.34073931
57negative regulation of muscle contraction (GO:0045932)3.32139239
58glycogen metabolic process (GO:0005977)3.29205846
59glucan metabolic process (GO:0044042)3.26588833
60cellular glucan metabolic process (GO:0006073)3.26588833
61pyrimidine nucleoside catabolic process (GO:0046135)3.25124170
62muscle structure development (GO:0061061)3.22234252
63regulation of striated muscle contraction (GO:0006942)3.21523275
64muscle adaptation (GO:0043500)3.21342483
65muscle organ development (GO:0007517)3.21191801
66adult heart development (GO:0007512)3.19371378
67fructose metabolic process (GO:0006000)3.15580800
68positive regulation of myotube differentiation (GO:0010831)3.15056810
69muscle atrophy (GO:0014889)3.14976634
70response to interleukin-15 (GO:0070672)3.14781202
71positive regulation of gamma-delta T cell activation (GO:0046645)3.14749074
72striated muscle cell development (GO:0055002)3.14147951
73carnitine shuttle (GO:0006853)3.13945231
74positive regulation of myoblast differentiation (GO:0045663)3.13836488
75regulation of activation of Janus kinase activity (GO:0010533)3.13710423
76muscle tissue morphogenesis (GO:0060415)3.11870787
77negative regulation of potassium ion transmembrane transport (GO:1901380)3.10479153
78cellular response to interleukin-15 (GO:0071350)3.08482430
79negative regulation of thymocyte apoptotic process (GO:0070244)3.07405207
80negative regulation of necroptotic process (GO:0060546)3.05755474
81negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03182365
82relaxation of muscle (GO:0090075)3.01204062
83muscle organ morphogenesis (GO:0048644)2.99081009
84regulation of homotypic cell-cell adhesion (GO:0034110)2.99065462
85cardiac muscle tissue morphogenesis (GO:0055008)2.98456113
86regulation of skeletal muscle fiber development (GO:0048742)2.92146681
87regulation of myotube differentiation (GO:0010830)2.90503948
88regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.87189701
89ADP metabolic process (GO:0046031)2.84971689
90regulation of sequestering of triglyceride (GO:0010889)2.83521569
912-oxoglutarate metabolic process (GO:0006103)2.81418048
92regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80896199
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80811245
94striated muscle tissue development (GO:0014706)2.80495009
95regulation of sequestering of calcium ion (GO:0051282)2.79351777
96cardiac muscle hypertrophy in response to stress (GO:0014898)2.78578025
97muscle hypertrophy in response to stress (GO:0003299)2.78578025
98cardiac muscle adaptation (GO:0014887)2.78578025
99muscle filament sliding (GO:0030049)10.2164497
100actin-myosin filament sliding (GO:0033275)10.2164497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08232087
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.81758242
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65515651
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63365694
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61650023
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48372464
7EZH2_22144423_ChIP-Seq_EOC_Human2.45033240
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42123169
9RUNX_20019798_ChIP-Seq_JUKART_Human2.29628844
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.25148696
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.11767999
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08902959
13BP1_19119308_ChIP-ChIP_Hs578T_Human10.5730424
14IGF1R_20145208_ChIP-Seq_DFB_Human1.79783900
15TBX20_22080862_ChIP-Seq_HEART_Mouse1.77771170
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.77771170
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.73989654
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63415016
19PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60226340
20GBX2_23144817_ChIP-Seq_PC3_Human1.53112502
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.50637710
22LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48975466
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48400145
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42836614
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.35595435
26AR_21572438_ChIP-Seq_LNCaP_Human1.35311198
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.32075689
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30887034
29MYB_26560356_Chip-Seq_TH2_Human1.25606467
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24891132
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22787654
32ER_23166858_ChIP-Seq_MCF-7_Human1.20760217
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16136685
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13583267
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.13321963
36VDR_24787735_ChIP-Seq_THP-1_Human1.07815050
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07338342
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07325384
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07177250
40MAF_26560356_Chip-Seq_TH1_Human1.06369796
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05930048
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04995491
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04739138
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04342610
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.03850134
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01949422
47DROSHA_22980978_ChIP-Seq_HELA_Human1.01409607
48VDR_22108803_ChIP-Seq_LS180_Human1.01354690
49SPI1_23127762_ChIP-Seq_K562_Human1.01207606
50GATA3_27048872_Chip-Seq_THYMUS_Human1.00931108
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98205887
52CJUN_26792858_Chip-Seq_BT549_Human0.97517939
53PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96799869
54FLI1_27457419_Chip-Seq_LIVER_Mouse0.95560527
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94276369
56MAF_26560356_Chip-Seq_TH2_Human0.93995397
57NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93705613
58HTT_18923047_ChIP-ChIP_STHdh_Human0.92985416
59STAT1_20625510_ChIP-Seq_HELA_Human0.92796573
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91060289
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90728456
62KDM2B_26808549_Chip-Seq_DND41_Human0.90235302
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89526238
64SPI1_20517297_ChIP-Seq_HL60_Human0.85842493
65CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84808528
66IRF8_27001747_Chip-Seq_BMDM_Mouse0.84694558
67UTX_26944678_Chip-Seq_JUKART_Human0.84417980
68SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83667502
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83446070
70SMAD3_21741376_ChIP-Seq_HESCs_Human0.81554419
71RXR_22108803_ChIP-Seq_LS180_Human0.80856647
72NANOG_20526341_ChIP-Seq_ESCs_Human0.80512224
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.80381276
74EZH2_27294783_Chip-Seq_NPCs_Mouse0.79784335
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78463666
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77721693
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76055663
78GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75843720
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75786907
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74570709
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74570709
82GATA2_19941826_ChIP-Seq_K562_Human0.74142060
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73785955
84SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73295136
85GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72755166
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72633749
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71355931
88MYB_26560356_Chip-Seq_TH1_Human0.70956490
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70852187
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.70666426
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70377481
92CEBPB_22108803_ChIP-Seq_LS180_Human0.70092210
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.69956031
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68582419
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66691620
96CTCF_21964334_Chip-Seq_Bcells_Human0.66363007
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.66009286
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.64952339
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64147631
100GATA3_26560356_Chip-Seq_TH2_Human0.63912631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.13022453
2MP0003646_muscle_fatigue6.01363654
3MP0000749_muscle_degeneration5.78191338
4MP0000751_myopathy4.63697994
5MP0004036_abnormal_muscle_relaxation4.33915624
6MP0004084_abnormal_cardiac_muscle3.99240095
7MP0005451_abnormal_body_composition3.92978850
8MP0002106_abnormal_muscle_physiology3.05635262
9MP0000759_abnormal_skeletal_muscle3.01148952
10MP0004087_abnormal_muscle_fiber2.93393365
11MP0002269_muscular_atrophy2.87579125
12MP0002332_abnormal_exercise_endurance2.87042803
13MP0005620_abnormal_muscle_contractility2.71888776
14MP0000747_muscle_weakness2.64055069
15MP0005369_muscle_phenotype2.61864770
16MP0004233_abnormal_muscle_weight2.58222062
17MP0004130_abnormal_muscle_cell2.55684029
18MP0005330_cardiomyopathy2.54689058
19MP0002837_dystrophic_cardiac_calcinosis2.39908074
20MP0000750_abnormal_muscle_regeneration2.16791236
21MP0002972_abnormal_cardiac_muscle2.04240153
22MP0005083_abnormal_biliary_tract1.95974524
23MP0004484_altered_response_of1.93086398
24MP0000733_abnormal_muscle_development1.74909198
25MP0004510_myositis1.73983214
26MP0002108_abnormal_muscle_morphology1.72397410
27MP0002127_abnormal_cardiovascular_syste1.67190510
28MP0004215_abnormal_myocardial_fiber1.59999493
29MP0000013_abnormal_adipose_tissue1.56578647
30MP0006036_abnormal_mitochondrial_physio1.52364453
31MP0006138_congestive_heart_failure1.49077259
32MP0005266_abnormal_metabolism1.39078888
33MP0001661_extended_life_span1.36428238
34MP0003763_abnormal_thymus_physiology1.35479038
35MP0005385_cardiovascular_system_phenoty1.35301722
36MP0001544_abnormal_cardiovascular_syste1.35301722
37MP0008004_abnormal_stomach_pH1.35279443
38MP0003828_pulmonary_edema1.33749795
39MP0005671_abnormal_response_to1.33407687
40MP0003045_fibrosis1.31752283
41MP0010630_abnormal_cardiac_muscle1.27285202
42MP0008775_abnormal_heart_ventricle1.06260110
43MP0005464_abnormal_platelet_physiology1.05853767
44MP0003221_abnormal_cardiomyocyte_apopto1.03800684
45MP0003950_abnormal_plasma_membrane1.02975235
46MP0003806_abnormal_nucleotide_metabolis1.01362977
47MP0005670_abnormal_white_adipose1.01332964
48MP0009785_altered_susceptibility_to0.96341536
49MP0003724_increased_susceptibility_to0.93845703
50MP0005167_abnormal_blood-brain_barrier0.86652318
51MP0005375_adipose_tissue_phenotype0.83397681
52MP0005166_decreased_susceptibility_to0.79737714
53MP0002971_abnormal_brown_adipose0.79470988
54MP0004381_abnormal_hair_follicle0.77725814
55MP0002138_abnormal_hepatobiliary_system0.76525193
56MP0005666_abnormal_adipose_tissue0.75295100
57MP0004185_abnormal_adipocyte_glucose0.74730295
58MP0000003_abnormal_adipose_tissue0.72724010
59MP0000343_altered_response_to0.71894389
60MP0005000_abnormal_immune_tolerance0.71182950
61MP0001800_abnormal_humoral_immune0.70821415
62MP0002723_abnormal_immune_serum0.61162875
63MP0003656_abnormal_erythrocyte_physiolo0.59520432
64MP0004043_abnormal_pH_regulation0.59483140
65MP0002148_abnormal_hypersensitivity_rea0.59110824
66MP0002420_abnormal_adaptive_immunity0.58724049
67MP0003252_abnormal_bile_duct0.57739643
68MP0003436_decreased_susceptibility_to0.57506337
69MP0004134_abnormal_chest_morphology0.57354715
70MP0002419_abnormal_innate_immunity0.56826903
71MP0001835_abnormal_antigen_presentation0.56125431
72MP0001819_abnormal_immune_cell0.55918382
73MP0008569_lethality_at_weaning0.55092363
74MP0005025_abnormal_response_to0.54988319
75MP0010368_abnormal_lymphatic_system0.54291974
76MP0002998_abnormal_bone_remodeling0.52508942
77MP0003300_gastrointestinal_ulcer0.52488464
78MP0002452_abnormal_antigen_presenting0.51881258
79MP0003137_abnormal_impulse_conducting0.51392177
80MP0001790_abnormal_immune_system0.50467641
81MP0005387_immune_system_phenotype0.50467641
82MP0002128_abnormal_blood_circulation0.50350047
83MP0002132_abnormal_respiratory_system0.50064735
84MP0000230_abnormal_systemic_arterial0.49900307
85MP0002933_joint_inflammation0.49299451
86MP0001873_stomach_inflammation0.48786437
87MP0000249_abnormal_blood_vessel0.48526871
88MP0005165_increased_susceptibility_to0.47898905
89MP0005376_homeostasis/metabolism_phenot0.47199093
90MP0005085_abnormal_gallbladder_physiolo0.46576192
91MP0005319_abnormal_enzyme/_coenzyme0.46327697
92MP0010155_abnormal_intestine_physiology0.46292228
93MP0002078_abnormal_glucose_homeostasis0.45301839
94MP0009333_abnormal_splenocyte_physiolog0.44401193
95MP0005584_abnormal_enzyme/coenzyme_acti0.44109596
96MP0009764_decreased_sensitivity_to0.42879687
97MP0004085_abnormal_heartbeat0.42724321
98MP0003959_abnormal_lean_body0.42088163
99MP0000703_abnormal_thymus_morphology0.41752827
100MP0002405_respiratory_system_inflammati0.41326186

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.90054125
2Exercise-induced myalgia (HP:0003738)7.95997312
3Type 1 muscle fiber predominance (HP:0003803)7.67719072
4Exercise-induced muscle cramps (HP:0003710)7.20436555
5Muscle hypertrophy of the lower extremities (HP:0008968)5.95150364
6Myopathic facies (HP:0002058)5.62060410
7Distal arthrogryposis (HP:0005684)5.53429819
8EMG: myopathic abnormalities (HP:0003458)5.52425242
9Hyporeflexia of lower limbs (HP:0002600)5.39596223
10Calf muscle hypertrophy (HP:0008981)5.38022361
11Muscle fiber splitting (HP:0003555)5.17138431
12Rhabdomyolysis (HP:0003201)5.11584277
13Myoglobinuria (HP:0002913)4.99679410
14Abnormality of skeletal muscle fiber size (HP:0012084)4.89166462
15Abnormality of the calf musculature (HP:0001430)4.59663715
16Neck muscle weakness (HP:0000467)4.56171698
17Centrally nucleated skeletal muscle fibers (HP:0003687)4.53313470
18Rimmed vacuoles (HP:0003805)4.53292039
19Increased variability in muscle fiber diameter (HP:0003557)4.44139367
20Round ear (HP:0100830)4.27330111
21Ulnar deviation of the wrist (HP:0003049)4.07818014
22Difficulty running (HP:0009046)3.84007318
23Subaortic stenosis (HP:0001682)3.68969717
24Abnormality of the left ventricular outflow tract (HP:0011103)3.68969717
25Areflexia of lower limbs (HP:0002522)3.54975406
26Muscle stiffness (HP:0003552)3.43353188
27Increased connective tissue (HP:0009025)3.42292806
28Frequent falls (HP:0002359)3.42179557
29Sudden death (HP:0001699)3.40430008
30Distal lower limb muscle weakness (HP:0009053)3.32342510
31Calcaneovalgus deformity (HP:0001848)3.25177901
32Malignant hyperthermia (HP:0002047)3.21074305
33Absent phalangeal crease (HP:0006109)3.06673550
34Scapular winging (HP:0003691)3.04937879
35Generalized muscle weakness (HP:0003324)3.00467157
36Deformed tarsal bones (HP:0008119)2.94340528
37Asymmetric septal hypertrophy (HP:0001670)2.91176383
38Myotonia (HP:0002486)2.85946155
39Bulbar palsy (HP:0001283)2.81403880
40Bundle branch block (HP:0011710)2.78369780
41Spinal rigidity (HP:0003306)2.76560697
42EMG: neuropathic changes (HP:0003445)2.76057774
43Muscular dystrophy (HP:0003560)2.73242018
44Dilated cardiomyopathy (HP:0001644)2.61094326
45Weak cry (HP:0001612)2.57347560
46Abnormality of the shoulder girdle musculature (HP:0001435)2.55343001
47Mildly elevated creatine phosphokinase (HP:0008180)2.54609902
48Abnormal finger flexion creases (HP:0006143)2.51716009
49Slender build (HP:0001533)2.47832256
50Lipoatrophy (HP:0100578)2.28990567
51Distal lower limb amyotrophy (HP:0008944)2.28053154
52Hyperkalemia (HP:0002153)2.26400554
53Progressive muscle weakness (HP:0003323)2.21627599
54Difficulty climbing stairs (HP:0003551)2.20696590
55Proximal amyotrophy (HP:0007126)2.20654838
56Ventricular tachycardia (HP:0004756)2.19868425
57Fetal akinesia sequence (HP:0001989)2.17260678
58Gowers sign (HP:0003391)2.17225040
59Facial diplegia (HP:0001349)2.14348059
60Abnormality of the neuromuscular junction (HP:0003398)2.12689222
61Fatigable weakness (HP:0003473)2.12689222
62Waddling gait (HP:0002515)2.12623786
63Limb-girdle muscle atrophy (HP:0003797)2.01482749
64Muscle fiber inclusion bodies (HP:0100299)10.4814820
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)10.0821642
66Abnormality of the foot musculature (HP:0001436)1.95272360
67Respiratory insufficiency due to muscle weakness (HP:0002747)1.91375703
68Foot dorsiflexor weakness (HP:0009027)1.90397176
69Nonprogressive disorder (HP:0003680)1.80457527
70Hip contracture (HP:0003273)1.80273568
71Paralysis (HP:0003470)1.79381695
72Ragged-red muscle fibers (HP:0003200)1.79364079
73Steppage gait (HP:0003376)1.74359953
74Clumsiness (HP:0002312)1.74004534
75Chest pain (HP:0100749)1.71729367
76Ulnar deviation of finger (HP:0009465)1.69057103
77Heart block (HP:0012722)1.68751127
78Type 2 muscle fiber atrophy (HP:0003554)1.67678794
79Abnormality of T cell number (HP:0011839)1.67569265
80Abnormality of the calcaneus (HP:0008364)1.66613340
81Ventricular arrhythmia (HP:0004308)1.66567193
82Pelvic girdle muscle weakness (HP:0003749)1.66213082
83Increased intramyocellular lipid droplets (HP:0012240)1.64872866
84Aortic aneurysm (HP:0004942)1.62618473
85Increased muscle lipid content (HP:0009058)1.62321674
86Abnormality of the hip-girdle musculature (HP:0001445)1.60398801
87Abnormality of the musculature of the pelvis (HP:0001469)1.60398801
88Muscle fiber atrophy (HP:0100295)1.58430779
89Exercise intolerance (HP:0003546)1.58240451
90Abnormal atrioventricular conduction (HP:0005150)1.57679924
91Popliteal pterygium (HP:0009756)1.57616923
92T lymphocytopenia (HP:0005403)1.57397342
93Shoulder girdle muscle weakness (HP:0003547)1.56331437
94Lower limb amyotrophy (HP:0007210)1.54030842
95Limb-girdle muscle weakness (HP:0003325)1.50943396
96Long clavicles (HP:0000890)1.44930826
97Easy fatigability (HP:0003388)1.43526845
98Ventricular fibrillation (HP:0001663)1.42334525
99Eosinophilia (HP:0001880)1.41553568
100Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.38970943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.84049444
2PHKG14.61040898
3PHKG24.61040898
4PINK13.45385002
5PIK3CG2.80545648
6TXK2.76351198
7OBSCN10.2257869
8MAPK121.89954573
9MAP3K71.80254478
10ARAF1.79811686
11MARK31.79069417
12CCNB11.70624009
13MAP3K101.41391635
14MOS1.39922634
15TRPM71.17829768
16MAP4K11.14958886
17MAP2K31.14722619
18MUSK1.06139179
19BLK1.01789758
20MAPKAPK30.99254580
21PIK3CA0.98121920
22ZAP700.97372862
23MAP3K130.92978361
24MYLK0.92560952
25EEF2K0.89714461
26NEK90.89219572
27GRK70.88375538
28TGFBR20.88211228
29ITK0.84697123
30PRKAA20.84367255
31PRKCQ0.78549154
32KDR0.75114233
33MAP3K10.72922395
34NME10.72157740
35SYK0.70366892
36NEK20.66949379
37TEC0.66876033
38CSK0.66703651
39BRAF0.64501028
40MAPK110.64339283
41PTK2B0.63706273
42TIE10.62625817
43PRKG20.61053522
44MAPK70.59889428
45GRK50.59736907
46CAMK2G0.58125007
47DMPK0.57220536
48CAMK40.54553974
49BTK0.54483714
50ROCK10.50610926
51LATS10.49926501
52TNK20.49438432
53RAF10.48319833
54PIM20.48230381
55PRKG10.47709354
56MAPK40.46654835
57MELK0.46549825
58RPS6KB10.46374771
59ADRBK20.46015134
60MAP2K40.44713702
61LATS20.44619685
62CAMK10.44225616
63MAP4K20.44049018
64HCK0.42687178
65JAK20.42034083
66TBK10.41924966
67FES0.41750155
68JAK30.41373444
69PRKAA10.37941651
70PDK10.36916263
71MAP3K30.34588938
72ERN10.34220754
73JAK10.33790563
74PDPK10.32260125
75GRK60.31894966
76RIPK10.31002551
77CAMK2D0.30943320
78AKT20.30219692
79MAP2K60.29169362
80RPS6KC10.28942733
81RPS6KL10.28942733
82PKN10.28631342
83DYRK1B0.27141904
84LCK0.27117612
85RPS6KA10.26444397
86LIMK10.26322768
87SGK30.25107360
88RPS6KA60.24821263
89NLK0.24465090
90CAMK2A0.24208879
91PRKACA0.24085377
92MAP3K140.23961380
93SGK20.23864532
94PAK10.23669072
95MAP3K50.23254339
96CDC42BPA0.22719916
97TRIB30.21724521
98RPS6KA20.20859179
99IKBKE0.20356485
100EPHB10.19637434

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.44599316
2Dilated cardiomyopathy_Homo sapiens_hsa054144.04096336
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.13166946
4Cardiac muscle contraction_Homo sapiens_hsa042602.79967852
5Circadian rhythm_Homo sapiens_hsa047102.49758413
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19857585
7Oxytocin signaling pathway_Homo sapiens_hsa049212.01278930
8cGMP-PKG signaling pathway_Homo sapiens_hsa040221.80645709
9T cell receptor signaling pathway_Homo sapiens_hsa046601.80426935
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80105252
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72739647
12Primary immunodeficiency_Homo sapiens_hsa053401.70712686
13Insulin signaling pathway_Homo sapiens_hsa049101.66765651
14Glucagon signaling pathway_Homo sapiens_hsa049221.65414551
15Calcium signaling pathway_Homo sapiens_hsa040201.63563861
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.62905965
17Insulin resistance_Homo sapiens_hsa049311.54025879
18Platelet activation_Homo sapiens_hsa046111.46848286
19Nitrogen metabolism_Homo sapiens_hsa009101.45188122
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40529187
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.39301140
22Viral myocarditis_Homo sapiens_hsa054161.37590075
23Arginine and proline metabolism_Homo sapiens_hsa003301.33039568
24Pentose phosphate pathway_Homo sapiens_hsa000301.30369895
25Autoimmune thyroid disease_Homo sapiens_hsa053201.29211971
26Hematopoietic cell lineage_Homo sapiens_hsa046401.23969033
27Renin secretion_Homo sapiens_hsa049241.22104998
28Graft-versus-host disease_Homo sapiens_hsa053321.21435437
29Gastric acid secretion_Homo sapiens_hsa049711.18801671
30Arginine biosynthesis_Homo sapiens_hsa002201.13672486
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10318774
32Fructose and mannose metabolism_Homo sapiens_hsa000511.10300900
33Focal adhesion_Homo sapiens_hsa045101.08905521
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.07890799
35AMPK signaling pathway_Homo sapiens_hsa041521.06784911
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05440001
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04100714
38Allograft rejection_Homo sapiens_hsa053301.03156966
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02671973
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02253972
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98063444
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95844435
43Starch and sucrose metabolism_Homo sapiens_hsa005000.95672047
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.90464029
45Malaria_Homo sapiens_hsa051440.90079692
46Rheumatoid arthritis_Homo sapiens_hsa053230.89989247
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87561870
48Salivary secretion_Homo sapiens_hsa049700.84364465
49FoxO signaling pathway_Homo sapiens_hsa040680.83628308
50Measles_Homo sapiens_hsa051620.82000388
51Fatty acid degradation_Homo sapiens_hsa000710.81805609
52Osteoclast differentiation_Homo sapiens_hsa043800.80643275
53Olfactory transduction_Homo sapiens_hsa047400.78403831
54Non-small cell lung cancer_Homo sapiens_hsa052230.76930659
55Chemokine signaling pathway_Homo sapiens_hsa040620.71926087
56MAPK signaling pathway_Homo sapiens_hsa040100.69698612
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67965506
58Carbon metabolism_Homo sapiens_hsa012000.67092873
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66876301
60Long-term depression_Homo sapiens_hsa047300.65538306
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64814906
62Long-term potentiation_Homo sapiens_hsa047200.61192849
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60844694
64Salmonella infection_Homo sapiens_hsa051320.58569134
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57542865
66Circadian entrainment_Homo sapiens_hsa047130.54988908
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54974245
68ECM-receptor interaction_Homo sapiens_hsa045120.54170952
69PPAR signaling pathway_Homo sapiens_hsa033200.53028965
70Tuberculosis_Homo sapiens_hsa051520.52017055
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.50609846
72VEGF signaling pathway_Homo sapiens_hsa043700.50057229
73B cell receptor signaling pathway_Homo sapiens_hsa046620.48581503
74GnRH signaling pathway_Homo sapiens_hsa049120.48300217
75Alzheimers disease_Homo sapiens_hsa050100.47427841
76Glioma_Homo sapiens_hsa052140.45582158
77Amoebiasis_Homo sapiens_hsa051460.44782977
78TNF signaling pathway_Homo sapiens_hsa046680.44680649
79Apoptosis_Homo sapiens_hsa042100.43953373
80Regulation of autophagy_Homo sapiens_hsa041400.43576316
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42582319
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41046003
83beta-Alanine metabolism_Homo sapiens_hsa004100.40838667
84Dorso-ventral axis formation_Homo sapiens_hsa043200.39702724
85Leishmaniasis_Homo sapiens_hsa051400.39480348
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39313275
87HTLV-I infection_Homo sapiens_hsa051660.39029378
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38226601
89Tight junction_Homo sapiens_hsa045300.38033799
90Type I diabetes mellitus_Homo sapiens_hsa049400.36628348
91Acute myeloid leukemia_Homo sapiens_hsa052210.36291051
92cAMP signaling pathway_Homo sapiens_hsa040240.35948496
93Propanoate metabolism_Homo sapiens_hsa006400.34790887
94Parkinsons disease_Homo sapiens_hsa050120.34750875
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33961022
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.33174113
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32505031
98Phenylalanine metabolism_Homo sapiens_hsa003600.32194945
99Endometrial cancer_Homo sapiens_hsa052130.30232487
100mTOR signaling pathway_Homo sapiens_hsa041500.29920590

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