SVIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.59515833
2axon ensheathment in central nervous system (GO:0032291)6.59515833
3protein neddylation (GO:0045116)6.44018550
4fatty acid elongation (GO:0030497)4.92080950
5neuronal action potential propagation (GO:0019227)4.45961407
6cellular ketone body metabolic process (GO:0046950)4.09682471
7protein complex biogenesis (GO:0070271)4.07658526
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03542999
9response to methylmercury (GO:0051597)3.97684577
10myelination (GO:0042552)3.95526025
11ensheathment of neurons (GO:0007272)3.95241573
12axon ensheathment (GO:0008366)3.95241573
13ATP synthesis coupled proton transport (GO:0015986)3.91073695
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.91073695
15ketone body metabolic process (GO:1902224)3.90639259
16presynaptic membrane assembly (GO:0097105)3.89912408
17long-chain fatty acid biosynthetic process (GO:0042759)3.89807053
18presynaptic membrane organization (GO:0097090)3.88537669
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84123053
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.84123053
21NADH dehydrogenase complex assembly (GO:0010257)3.84123053
22neuron cell-cell adhesion (GO:0007158)3.68041742
23negative regulation of neurotransmitter transport (GO:0051589)3.66639522
24DNA deamination (GO:0045006)3.65180287
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62742963
26mitochondrial respiratory chain complex assembly (GO:0033108)3.61447011
27platelet dense granule organization (GO:0060155)3.52683066
28negative regulation of neurotransmitter secretion (GO:0046929)3.48063536
29synaptic vesicle exocytosis (GO:0016079)3.47438738
30regulation of synaptic vesicle exocytosis (GO:2000300)3.45758981
31negative regulation of response to food (GO:0032096)3.45666981
32negative regulation of appetite (GO:0032099)3.45666981
33dopamine transport (GO:0015872)3.45379408
34synaptic vesicle maturation (GO:0016188)3.42375899
35negative regulation of heart rate (GO:0010459)3.42253260
36acrosome reaction (GO:0007340)3.25443699
37adult walking behavior (GO:0007628)3.21640427
38negative regulation of inclusion body assembly (GO:0090084)3.18002033
39regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.13936598
40autophagic vacuole fusion (GO:0000046)3.11947852
41respiratory chain complex IV assembly (GO:0008535)3.11376106
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11104859
43signal peptide processing (GO:0006465)3.10722222
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.10705471
45calcium ion-dependent exocytosis (GO:0017156)3.09814712
46thrombin receptor signaling pathway (GO:0070493)3.09717456
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08213495
48glycerophospholipid catabolic process (GO:0046475)3.07962680
49establishment of mitochondrion localization (GO:0051654)3.07586492
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06245175
51myelin maintenance (GO:0043217)3.06049682
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04983208
53organelle membrane fusion (GO:0090174)3.03876073
54regulation of synaptic vesicle transport (GO:1902803)3.02961254
55transmission of nerve impulse (GO:0019226)2.98566427
56glutamate secretion (GO:0014047)2.95688321
57regulation of hexokinase activity (GO:1903299)2.95442798
58regulation of glucokinase activity (GO:0033131)2.95442798
59inositol phosphate catabolic process (GO:0071545)2.95237478
60inositol phosphate dephosphorylation (GO:0046855)2.94986545
61phosphorylated carbohydrate dephosphorylation (GO:0046838)2.94986545
62water-soluble vitamin biosynthetic process (GO:0042364)2.93770902
63protein localization to synapse (GO:0035418)2.92754959
64substantia nigra development (GO:0021762)2.92293488
65regulation of cilium movement (GO:0003352)2.90848568
66nitric oxide mediated signal transduction (GO:0007263)2.90131304
67neuronal ion channel clustering (GO:0045161)2.89154854
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88570659
69L-amino acid import (GO:0043092)2.87127079
70polyol catabolic process (GO:0046174)2.85900816
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.84748407
72hydrogen ion transmembrane transport (GO:1902600)2.84566309
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.84307884
74magnesium ion transport (GO:0015693)2.82332816
75glycine transport (GO:0015816)2.82064285
76apical protein localization (GO:0045176)2.80347169
77cholesterol biosynthetic process (GO:0006695)2.78734968
78cytochrome complex assembly (GO:0017004)2.78105505
79creatine metabolic process (GO:0006600)2.77683968
80neuron-neuron synaptic transmission (GO:0007270)2.77267634
81regulation of oxidative phosphorylation (GO:0002082)2.77251493
82vocalization behavior (GO:0071625)2.75865403
83sperm capacitation (GO:0048240)2.75546666
84protein-cofactor linkage (GO:0018065)2.75189809
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74273555
86photoreceptor cell differentiation (GO:0046530)2.72779733
87eye photoreceptor cell differentiation (GO:0001754)2.72779733
88locomotory exploration behavior (GO:0035641)2.72776540
89oligodendrocyte differentiation (GO:0048709)2.72554599
90behavioral response to nicotine (GO:0035095)2.72305589
91positive regulation of cAMP-mediated signaling (GO:0043950)2.72273837
92synaptic transmission, glutamatergic (GO:0035249)2.71728521
93neurotransmitter uptake (GO:0001504)2.71188440
94regulation of catecholamine metabolic process (GO:0042069)2.70801905
95regulation of dopamine metabolic process (GO:0042053)2.70801905
96proton transport (GO:0015992)2.70260258
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.69103249
98neuromuscular process controlling posture (GO:0050884)2.68682696
99mitochondrial calcium ion transport (GO:0006851)2.67665404
100gamma-aminobutyric acid transport (GO:0015812)2.67284406
101hydrogen transport (GO:0006818)2.67112200
102deoxyribose phosphate biosynthetic process (GO:0046385)2.65657541
1032-deoxyribonucleotide biosynthetic process (GO:0009265)2.65657541
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64194865
105L-phenylalanine catabolic process (GO:0006559)2.64194865
106response to redox state (GO:0051775)2.62784112
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62758375
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.61259452
109fatty-acyl-CoA metabolic process (GO:0035337)2.60789975
110positive regulation of membrane potential (GO:0045838)2.60489777
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58998269
112regulation of female receptivity (GO:0045924)2.58960176
113xenobiotic catabolic process (GO:0042178)2.58323850
114negative regulation of protein localization to cell surface (GO:2000009)2.58242721
115sperm motility (GO:0030317)2.58197328
116regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56023751
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55333350
118regulation of voltage-gated calcium channel activity (GO:1901385)2.54406740
119positive regulation of respiratory burst (GO:0060267)2.53947451
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53782471
121protein palmitoylation (GO:0018345)2.53740110
122monoamine transport (GO:0015844)2.53698376
123regulation of collateral sprouting (GO:0048670)2.52552110
124ATP biosynthetic process (GO:0006754)2.52175261
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.52084000
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51817855
127nonmotile primary cilium assembly (GO:0035058)2.51626961
128asymmetric protein localization (GO:0008105)2.51607598
129detection of temperature stimulus (GO:0016048)2.50730941
130adenosine metabolic process (GO:0046085)2.50561697
131peptidyl-tyrosine autophosphorylation (GO:0038083)2.49176860
132purinergic nucleotide receptor signaling pathway (GO:0035590)2.48651115
133endocrine pancreas development (GO:0031018)2.48273183
134chaperone-mediated protein transport (GO:0072321)2.48155156
135response to epinephrine (GO:0071871)2.47682625
136rRNA modification (GO:0000154)2.47317991
137neurotransmitter transport (GO:0006836)2.46811808
138neurotransmitter secretion (GO:0007269)2.46780972
139regulation of neuronal synaptic plasticity (GO:0048168)2.46611727
140sterol biosynthetic process (GO:0016126)2.46234906
141peptidyl-cysteine modification (GO:0018198)2.45949137
142nerve growth factor signaling pathway (GO:0038180)2.45598280
143relaxation of smooth muscle (GO:0044557)2.43956303
144calcium-mediated signaling using intracellular calcium source (GO:0035584)2.43665837
145purine-containing compound salvage (GO:0043101)2.43503484
146respiratory electron transport chain (GO:0022904)2.43016496
147energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.42987898
148ATP hydrolysis coupled proton transport (GO:0015991)2.42987898
149membrane hyperpolarization (GO:0060081)2.42850452
150protein K6-linked ubiquitination (GO:0085020)2.42803436
151positive regulation of protein homodimerization activity (GO:0090073)2.42772022
152epithelial cilium movement (GO:0003351)2.42035448
153glutamate receptor signaling pathway (GO:0007215)2.41833697
154mechanosensory behavior (GO:0007638)2.41499298
155positive regulation of glycolytic process (GO:0045821)2.41480738
156nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41413526
157positive regulation of action potential (GO:0045760)2.41036147
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.40808392
159detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.40808392
160electron transport chain (GO:0022900)2.39644038
161fusion of sperm to egg plasma membrane (GO:0007342)2.39444560
162sequestering of actin monomers (GO:0042989)2.38470896
163mannosylation (GO:0097502)2.38379959
164detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38285686
165positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38062906
166adult locomotory behavior (GO:0008344)2.37864515
167detection of calcium ion (GO:0005513)2.37604350
168regulation of type B pancreatic cell apoptotic process (GO:2000674)2.37080817
169cellular response to epinephrine stimulus (GO:0071872)2.36903578
170regulation of vesicle fusion (GO:0031338)2.36426184
171Golgi to endosome transport (GO:0006895)2.36309800
172regulation of amyloid precursor protein catabolic process (GO:1902991)2.36167517
173cellular biogenic amine biosynthetic process (GO:0042401)2.35517911
174catecholamine transport (GO:0051937)2.35494837
175protein localization to cilium (GO:0061512)2.35408358
176positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34382087
177regulation of response to food (GO:0032095)2.33198243
178regulation of appetite (GO:0032098)2.32903092
179exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.31716144
180preassembly of GPI anchor in ER membrane (GO:0016254)2.31395832
181cardiolipin metabolic process (GO:0032048)2.30981941
182insulin secretion (GO:0030073)2.30738509
183rRNA methylation (GO:0031167)2.30480185
184axoneme assembly (GO:0035082)2.29725864
185phosphatidylinositol acyl-chain remodeling (GO:0036149)2.28326989
186purine nucleoside triphosphate biosynthetic process (GO:0009145)2.26471189
187purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.23890647
188female mating behavior (GO:0060180)2.22713968
189L-fucose catabolic process (GO:0042355)2.22365273
190fucose catabolic process (GO:0019317)2.22365273
191L-fucose metabolic process (GO:0042354)2.22365273
192negative regulation of norepinephrine secretion (GO:0010700)2.22034633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11638017
2GBX2_23144817_ChIP-Seq_PC3_Human3.43136139
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.95422068
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60316159
5TAF15_26573619_Chip-Seq_HEK293_Human2.59350415
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38960350
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36244827
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36179340
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.33784246
10REST_21632747_ChIP-Seq_MESCs_Mouse2.32311251
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24243142
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.23416727
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22760875
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12652282
15EWS_26573619_Chip-Seq_HEK293_Human2.09769432
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03134494
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02575510
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94330562
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.92142324
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91813450
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.91118069
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89558203
23VDR_22108803_ChIP-Seq_LS180_Human1.88265726
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87066077
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86948759
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83650083
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82147846
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81911758
29TP53_22573176_ChIP-Seq_HFKS_Human1.81776016
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.78152159
31VDR_23849224_ChIP-Seq_CD4+_Human1.76435369
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76329576
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.74902594
34IRF1_19129219_ChIP-ChIP_H3396_Human1.73958235
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71921855
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71386930
37DROSHA_22980978_ChIP-Seq_HELA_Human1.69771125
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69104571
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68916044
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68431459
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67035453
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67035453
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.55809450
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55511306
45ER_23166858_ChIP-Seq_MCF-7_Human1.53137541
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52907854
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52304886
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52128790
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.52128790
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48264731
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48045671
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47935569
53P300_19829295_ChIP-Seq_ESCs_Human1.42364440
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.41108797
55SMAD4_21799915_ChIP-Seq_A2780_Human1.41037623
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.39096310
57ELK1_19687146_ChIP-ChIP_HELA_Human1.38450420
58MYC_18940864_ChIP-ChIP_HL60_Human1.38178319
59AR_20517297_ChIP-Seq_VCAP_Human1.37653814
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36404848
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.36077795
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.34971942
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34744776
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33375281
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31428073
66FUS_26573619_Chip-Seq_HEK293_Human1.31423093
67ZNF274_21170338_ChIP-Seq_K562_Hela1.30539132
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.30506951
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29763320
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28842586
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.28367909
72* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26700556
73ERG_20517297_ChIP-Seq_VCAP_Human1.26205361
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.25391222
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24845357
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24726908
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24602813
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23783287
79* TAL1_26923725_Chip-Seq_HPCs_Mouse1.23263021
80STAT3_23295773_ChIP-Seq_U87_Human1.22798480
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22157809
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.20545782
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20464345
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20393008
85TCF4_23295773_ChIP-Seq_U87_Human1.19780040
86IGF1R_20145208_ChIP-Seq_DFB_Human1.18818389
87* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18319149
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17954368
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.17810357
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17692508
91FOXP3_21729870_ChIP-Seq_TREG_Human1.16581060
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16356741
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15190496
94KDM2B_26808549_Chip-Seq_REH_Human1.15054827
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13159246
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13147934
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.12015101
98HTT_18923047_ChIP-ChIP_STHdh_Human1.12003310
99* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11046785
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09663914
101NCOR_22424771_ChIP-Seq_293T_Human1.09417522
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09089125
103AR_21572438_ChIP-Seq_LNCaP_Human1.08156214
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.07700801
105* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07251016
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06869686
107BCAT_22108803_ChIP-Seq_LS180_Human1.06831407
108RNF2_27304074_Chip-Seq_NSC_Mouse1.03547497
109SCL_19346495_ChIP-Seq_HPC-7_Human1.03540157
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03480194
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.02823791
112P53_22387025_ChIP-Seq_ESCs_Mouse1.02794492
113* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02680726
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.02491946
115CBP_20019798_ChIP-Seq_JUKART_Human1.01953017
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01953017
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01803589
118AR_25329375_ChIP-Seq_VCAP_Human1.01357032
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.01088829
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00657383
121P300_18555785_Chip-Seq_ESCs_Mouse1.00439907
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00424894
123TAF2_19829295_ChIP-Seq_ESCs_Human1.00165223
124GATA3_26560356_Chip-Seq_TH2_Human0.99702879
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.98562523
126CDX2_22108803_ChIP-Seq_LS180_Human0.98473319
127TCF4_22108803_ChIP-Seq_LS180_Human0.97908689
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97419724
129NANOG_19829295_ChIP-Seq_ESCs_Human0.95720666
130SOX2_19829295_ChIP-Seq_ESCs_Human0.95720666
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95424750
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.95377883
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94913671
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94900840
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.93836100
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93410623
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93301345
138SOX2_18555785_Chip-Seq_ESCs_Mouse0.93149464
139RBPJ_21746931_ChIP-Seq_IB4_Human0.92741480
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.92331827
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91955453
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91945147
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91780118
144* PRDM14_20953172_ChIP-Seq_ESCs_Human0.91117585
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91053313
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90032059
147SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89514786
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89460132
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89192866
150* RUNX2_22187159_ChIP-Seq_PCA_Human0.87737253
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87683025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.22444059
2MP0004270_analgesia3.67034266
3MP0004859_abnormal_synaptic_plasticity3.60145469
4MP0005464_abnormal_platelet_physiology3.10828841
5MP0005410_abnormal_fertilization3.05942709
6MP0000920_abnormal_myelination2.98651329
7MP0002272_abnormal_nervous_system2.81080846
8MP0003635_abnormal_synaptic_transmissio2.74697719
9MP0002064_seizures2.63903067
10MP0009046_muscle_twitch2.62282006
11MP0009745_abnormal_behavioral_response2.52263105
12MP0001968_abnormal_touch/_nociception2.47752087
13MP0002734_abnormal_mechanical_nocicepti2.40033426
14MP0001529_abnormal_vocalization2.39066521
15MP0001486_abnormal_startle_reflex2.35114851
16MP0003329_amyloid_beta_deposits2.31109188
17MP0000372_irregular_coat_pigmentation2.19687781
18MP0004043_abnormal_pH_regulation2.16683599
19MP0002735_abnormal_chemical_nociception2.11752836
20MP0002736_abnormal_nociception_after2.10971971
21MP0002063_abnormal_learning/memory/cond2.10703518
22MP0005423_abnormal_somatic_nervous2.07175529
23MP0001905_abnormal_dopamine_level2.02072408
24MP0002572_abnormal_emotion/affect_behav2.01892613
25MP0002822_catalepsy1.99866428
26MP0002733_abnormal_thermal_nociception1.99656273
27MP0001970_abnormal_pain_threshold1.95954210
28MP0004142_abnormal_muscle_tone1.95546774
29MP0005084_abnormal_gallbladder_morpholo1.91502591
30MP0005646_abnormal_pituitary_gland1.88769519
31MP0002229_neurodegeneration1.81075818
32MP0001986_abnormal_taste_sensitivity1.79914820
33MP0002163_abnormal_gland_morphology1.78430185
34MP0002638_abnormal_pupillary_reflex1.77449831
35MP0002067_abnormal_sensory_capabilities1.77444995
36MP0004885_abnormal_endolymph1.71192787
37MP0004147_increased_porphyrin_level1.66935167
38MP0003690_abnormal_glial_cell1.66241375
39MP0008569_lethality_at_weaning1.62247796
40MP0004742_abnormal_vestibular_system1.62136555
41MP0005551_abnormal_eye_electrophysiolog1.61804545
42MP0001485_abnormal_pinna_reflex1.60286280
43MP0002837_dystrophic_cardiac_calcinosis1.58845930
44MP0002102_abnormal_ear_morphology1.57770147
45MP0003183_abnormal_peptide_metabolism1.55699470
46MP0003634_abnormal_glial_cell1.54302546
47MP0003283_abnormal_digestive_organ1.53181429
48MP0001440_abnormal_grooming_behavior1.53080203
49MP0006276_abnormal_autonomic_nervous1.52305234
50MP0004924_abnormal_behavior1.50900265
51MP0005386_behavior/neurological_phenoty1.50900265
52MP0009780_abnormal_chondrocyte_physiolo1.48799380
53MP0003011_delayed_dark_adaptation1.47959342
54MP0000955_abnormal_spinal_cord1.46466833
55MP0003633_abnormal_nervous_system1.46295375
56MP0005174_abnormal_tail_pigmentation1.45765194
57MP0004145_abnormal_muscle_electrophysio1.44378040
58MP0006072_abnormal_retinal_apoptosis1.44252061
59MP0002160_abnormal_reproductive_system1.42884579
60MP0003123_paternal_imprinting1.41281423
61MP0001501_abnormal_sleep_pattern1.39237512
62MP0005075_abnormal_melanosome_morpholog1.35293173
63MP0002066_abnormal_motor_capabilities/c1.34980014
64MP0005389_reproductive_system_phenotype1.34402186
65MP0003631_nervous_system_phenotype1.34213737
66MP0001919_abnormal_reproductive_system1.33522495
67MP0002882_abnormal_neuron_morphology1.33179818
68MP0008004_abnormal_stomach_pH1.31342346
69MP0001944_abnormal_pancreas_morphology1.31053761
70MP0003718_maternal_effect1.30770807
71MP0000015_abnormal_ear_pigmentation1.30384288
72MP0000778_abnormal_nervous_system1.26907151
73MP0002095_abnormal_skin_pigmentation1.26643468
74MP0005636_abnormal_mineral_homeostasis1.25988350
75MP0005409_darkened_coat_color1.23713696
76MP0003950_abnormal_plasma_membrane1.23670375
77MP0000230_abnormal_systemic_arterial1.22996900
78MP0009379_abnormal_foot_pigmentation1.22429051
79MP0003632_abnormal_nervous_system1.21976173
80MP0003186_abnormal_redox_activity1.18797738
81MP0008057_abnormal_DNA_replication1.18375478
82MP0008875_abnormal_xenobiotic_pharmacok1.17629833
83MP0003656_abnormal_erythrocyte_physiolo1.16616947
84MP0002909_abnormal_adrenal_gland1.15249463
85MP0000013_abnormal_adipose_tissue1.15105181
86MP0004811_abnormal_neuron_physiology1.14633609
87MP0001963_abnormal_hearing_physiology1.13938626
88MP0000569_abnormal_digit_pigmentation1.11770522
89MP0001756_abnormal_urination1.10787610
90MP0001502_abnormal_circadian_rhythm1.10148721
91MP0002557_abnormal_social/conspecific_i1.10043470
92MP0003879_abnormal_hair_cell1.09152546
93MP0003698_abnormal_male_reproductive1.08768413
94MP0001984_abnormal_olfaction1.07433556
95MP0005253_abnormal_eye_physiology1.06940155
96MP0005220_abnormal_exocrine_pancreas1.04495796
97MP0006036_abnormal_mitochondrial_physio1.04451035
98MP0008775_abnormal_heart_ventricle1.04267686
99MP0002184_abnormal_innervation1.04012506
100MP0000604_amyloidosis1.03953402
101MP0000462_abnormal_digestive_system1.03806847
102MP0005171_absent_coat_pigmentation1.03401915
103MP0003121_genomic_imprinting1.02612828
104MP0003806_abnormal_nucleotide_metabolis1.02149428
105MP0005535_abnormal_body_temperature1.00561287
106MP0003195_calcinosis0.98653960
107MP0004036_abnormal_muscle_relaxation0.96956060
108MP0005645_abnormal_hypothalamus_physiol0.96058288
109MP0006035_abnormal_mitochondrial_morpho0.95092218
110MP0000747_muscle_weakness0.93934766
111MP0009697_abnormal_copulation0.92667472
112MP0002752_abnormal_somatic_nervous0.91886340
113MP0000751_myopathy0.91795159
114MP0002653_abnormal_ependyma_morphology0.91652100
115MP0002078_abnormal_glucose_homeostasis0.90117209
116MP0003638_abnormal_response/metabolism_0.89598675
117MP0001765_abnormal_ion_homeostasis0.89550941
118MP0010386_abnormal_urinary_bladder0.89454807
119MP0005083_abnormal_biliary_tract0.89152407
120MP0010329_abnormal_lipoprotein_level0.88004654
121MP0002928_abnormal_bile_duct0.87608814
122MP0001188_hyperpigmentation0.84962066
123MP0005379_endocrine/exocrine_gland_phen0.83415354
124MP0003953_abnormal_hormone_level0.83034819
125MP0005408_hypopigmentation0.83001011
126MP0004215_abnormal_myocardial_fiber0.82460027
127MP0000749_muscle_degeneration0.82398802
128MP0000631_abnormal_neuroendocrine_gland0.82052087
129MP0008995_early_reproductive_senescence0.81461292
130MP0004019_abnormal_vitamin_homeostasis0.80834869
131MP0008260_abnormal_autophagy0.78170693
132MP0001664_abnormal_digestion0.78082285
133MP0002152_abnormal_brain_morphology0.77728137
134MP0003136_yellow_coat_color0.76879294
135MP0004085_abnormal_heartbeat0.75201301
136MP0008877_abnormal_DNA_methylation0.74270879
137MP0002876_abnormal_thyroid_physiology0.74047069
138MP0008874_decreased_physiological_sensi0.71206397
139MP0002069_abnormal_eating/drinking_beha0.70376820
140MP0003172_abnormal_lysosome_physiology0.69998595
141MP0008872_abnormal_physiological_respon0.69665791
142MP0001929_abnormal_gametogenesis0.68265419
143MP0003787_abnormal_imprinting0.67605494
144MP0002693_abnormal_pancreas_physiology0.64033641

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.55773719
2Myokymia (HP:0002411)4.49310224
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.45814356
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.45814356
5Neurofibrillary tangles (HP:0002185)4.24298790
6Prolonged bleeding time (HP:0003010)3.92426698
73-Methylglutaconic aciduria (HP:0003535)3.79053041
8Supranuclear gaze palsy (HP:0000605)3.55545515
9Pheochromocytoma (HP:0002666)3.50714445
10Abnormality of the corticospinal tract (HP:0002492)3.50554134
11Petechiae (HP:0000967)3.41854714
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.38970750
13Absent/shortened dynein arms (HP:0200106)3.38970750
14Peripheral hypomyelination (HP:0007182)3.33934574
15Atonic seizures (HP:0010819)3.25431657
16Spastic gait (HP:0002064)3.23258661
17Sensory axonal neuropathy (HP:0003390)3.19066274
18Cerebral inclusion bodies (HP:0100314)3.14242810
19Termporal pattern (HP:0011008)3.14238439
20Insidious onset (HP:0003587)3.14238439
21Neuroendocrine neoplasm (HP:0100634)3.13928338
22Retinal dysplasia (HP:0007973)3.12431644
23Ankle clonus (HP:0011448)3.04306522
24Epileptic encephalopathy (HP:0200134)2.99443627
25Dysmetria (HP:0001310)2.99043646
26Acute necrotizing encephalopathy (HP:0006965)2.98054237
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97285174
28Ketoacidosis (HP:0001993)2.96288133
29Menorrhagia (HP:0000132)2.95218915
30Focal seizures (HP:0007359)2.94646242
31Hypothermia (HP:0002045)2.92665674
32Visual hallucinations (HP:0002367)2.92473969
33Hypoglycemic coma (HP:0001325)2.80013965
34Abnormal mitochondria in muscle tissue (HP:0008316)2.74182729
35Acute encephalopathy (HP:0006846)2.69823072
36Intention tremor (HP:0002080)2.69551107
37Onion bulb formation (HP:0003383)2.67469540
38Hyperventilation (HP:0002883)2.67142201
39Increased mean platelet volume (HP:0011877)2.66873039
40Increased hepatocellular lipid droplets (HP:0006565)2.65751521
41Cerebral hypomyelination (HP:0006808)2.65593207
42Congenital stationary night blindness (HP:0007642)2.64654694
43Pancreatic cysts (HP:0001737)2.64501402
44Renal cortical cysts (HP:0000803)2.63703481
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62468029
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62468029
47Action tremor (HP:0002345)2.62079066
48Progressive macrocephaly (HP:0004481)2.61723769
49Leukodystrophy (HP:0002415)2.60897340
50Dialeptic seizures (HP:0011146)2.56916648
51Scanning speech (HP:0002168)2.52516752
52Congenital, generalized hypertrichosis (HP:0004540)2.49375996
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.48972390
54Lipid accumulation in hepatocytes (HP:0006561)2.48459242
55Abnormality of the renal cortex (HP:0011035)2.47786989
56Mitochondrial inheritance (HP:0001427)2.45437177
57Poikilocytosis (HP:0004447)2.45269707
58Absence seizures (HP:0002121)2.42469066
59Anxiety (HP:0000739)2.41547567
60Abnormal respiratory motile cilium physiology (HP:0012261)2.40840830
61Abnormality of magnesium homeostasis (HP:0004921)2.38982293
62Molar tooth sign on MRI (HP:0002419)2.37583941
63Abnormality of midbrain morphology (HP:0002418)2.37583941
64Hyperlipoproteinemia (HP:0010980)2.36219364
65Abnormal platelet volume (HP:0011876)2.35984689
66Exertional dyspnea (HP:0002875)2.35566938
67Abnormality of urine glucose concentration (HP:0011016)2.35473135
68Glycosuria (HP:0003076)2.35473135
69Progressive cerebellar ataxia (HP:0002073)2.35220495
70Generalized tonic-clonic seizures (HP:0002069)2.34803428
71Gaze-evoked nystagmus (HP:0000640)2.34155567
72Pancreatic fibrosis (HP:0100732)2.33411948
73Decreased central vision (HP:0007663)2.33074095
74Purpura (HP:0000979)2.31319146
75Cerebral edema (HP:0002181)2.30708687
76Hyperthyroidism (HP:0000836)2.30074791
77Type II lissencephaly (HP:0007260)2.30027940
78Abnormality of renal resorption (HP:0011038)2.29754615
79Febrile seizures (HP:0002373)2.29469962
80Ketosis (HP:0001946)2.25077589
81Slow saccadic eye movements (HP:0000514)2.24244951
82Urinary urgency (HP:0000012)2.23889521
83CNS hypomyelination (HP:0003429)2.23815919
84Progressive inability to walk (HP:0002505)2.23793337
85Methylmalonic acidemia (HP:0002912)2.23556232
86Abnormal ciliary motility (HP:0012262)2.22177868
87Hepatocellular necrosis (HP:0001404)2.21515274
88Increased intramyocellular lipid droplets (HP:0012240)2.21455253
89True hermaphroditism (HP:0010459)2.20132990
90Epistaxis (HP:0000421)2.19488740
91Increased serum pyruvate (HP:0003542)2.19275462
92Abnormality of glycolysis (HP:0004366)2.19275462
93Abnormal respiratory motile cilium morphology (HP:0005938)2.16094250
94Abnormal respiratory epithelium morphology (HP:0012253)2.16094250
95Clonus (HP:0002169)2.15641142
96Broad-based gait (HP:0002136)2.15528113
97Abnormal number of erythroid precursors (HP:0012131)2.14589712
98Truncal ataxia (HP:0002078)2.14143076
99Increased circulating renin level (HP:0000848)2.11401021
100Medial flaring of the eyebrow (HP:0010747)2.11211260
101Generalized aminoaciduria (HP:0002909)2.10797917
102Polydipsia (HP:0001959)2.10321264
103Abnormal drinking behavior (HP:0030082)2.10321264
104Stomatitis (HP:0010280)2.10161410
105Parakeratosis (HP:0001036)2.09664628
106Optic disc pallor (HP:0000543)2.08333419
107Hypoglycemic seizures (HP:0002173)2.07817014
108Cerebral hemorrhage (HP:0001342)2.07599374
109Akinesia (HP:0002304)2.06630158
110Abnormality of the pancreatic islet cells (HP:0006476)2.05400268
111Abnormality of endocrine pancreas physiology (HP:0012093)2.05400268
112Lower limb muscle weakness (HP:0007340)2.05270691
113Urinary bladder sphincter dysfunction (HP:0002839)2.05180689
114Respiratory failure (HP:0002878)2.04730962
115Aplasia/Hypoplasia of the fovea (HP:0008060)2.03568313
116Hypoplasia of the fovea (HP:0007750)2.03568313
117Limb dystonia (HP:0002451)2.02970383
118Nephronophthisis (HP:0000090)2.02239826
119Large for gestational age (HP:0001520)2.02187880
120Papilledema (HP:0001085)2.01892011
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01875923
122Abnormal auditory evoked potentials (HP:0006958)2.01874506
123Impaired vibration sensation in the lower limbs (HP:0002166)2.00730999
124Hepatic necrosis (HP:0002605)1.99610737
125Increased CSF lactate (HP:0002490)1.99417131
126Postural instability (HP:0002172)1.99068442
127Abnormality of alanine metabolism (HP:0010916)1.98266537
128Hyperalaninemia (HP:0003348)1.98266537
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98266537
130Dyschromatopsia (HP:0007641)1.97939772
131Depression (HP:0000716)1.97594495
132Methylmalonic aciduria (HP:0012120)1.96869586
133Abnormality of cells of the erythroid lineage (HP:0012130)1.96589865
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96324463
135Poor speech (HP:0002465)1.96135242
136Cholecystitis (HP:0001082)1.95688144
137Abnormal gallbladder physiology (HP:0012438)1.95688144
138Dysdiadochokinesis (HP:0002075)1.95342983
139Tongue fasciculations (HP:0001308)1.93821106
140Lactic acidosis (HP:0003128)1.93731537
141Abnormality of saccadic eye movements (HP:0000570)1.92197336
142Insulin-resistant diabetes mellitus (HP:0000831)1.92081036
143Abnormal pupillary function (HP:0007686)1.91471815
144Gait imbalance (HP:0002141)1.90348342
145Epileptiform EEG discharges (HP:0011182)1.88071723
146Renal Fanconi syndrome (HP:0001994)1.87115396
147Generalized myoclonic seizures (HP:0002123)1.86867781
148Abnormality of vitamin B metabolism (HP:0004340)1.86323160
149EEG with generalized epileptiform discharges (HP:0011198)1.85231977
150Increased serum lactate (HP:0002151)1.84923784
151Male pseudohermaphroditism (HP:0000037)1.84636260
152Pancreatic islet-cell hyperplasia (HP:0004510)1.83743945
153Spastic paraparesis (HP:0002313)1.82708967
154Psychosis (HP:0000709)1.82018419
155Delusions (HP:0000746)1.81432250
156Lethargy (HP:0001254)1.81320635
157Abnormal rod and cone electroretinograms (HP:0008323)1.80113466
158Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79921645
159Acanthocytosis (HP:0001927)1.79745816
160Attenuation of retinal blood vessels (HP:0007843)1.79734579
161Vaginal atresia (HP:0000148)1.79712542
162Hypsarrhythmia (HP:0002521)1.79624157
163Rigidity (HP:0002063)1.79609656
164Hyperinsulinemic hypoglycemia (HP:0000825)1.78963859
165Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78944649
166Abnormality of the fovea (HP:0000493)1.78847301
167Clumsiness (HP:0002312)1.77777302
168Hypomagnesemia (HP:0002917)1.77479168
169Genital tract atresia (HP:0001827)1.76840135
170Increased muscle lipid content (HP:0009058)1.75781746
171Congenital primary aphakia (HP:0007707)1.75681340
172Abnormal eating behavior (HP:0100738)1.75518728
173Ventricular fibrillation (HP:0001663)1.75230274
174Abnormality of the renal medulla (HP:0100957)1.75129931
175Hyperglycemia (HP:0003074)1.74899959
176Polyphagia (HP:0002591)1.74573200
177Segmental peripheral demyelination/remyelination (HP:0003481)1.73045587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.48652312
2FRK4.01743636
3MST43.53921508
4OXSR13.36259201
5EIF2AK12.98389420
6CASK2.83267542
7CDK192.70301679
8WNK42.51571742
9TNIK2.44858974
10EPHA42.25249448
11NTRK32.16760456
12MAPKAPK52.09888151
13NTRK12.00548437
14UHMK11.99878952
15WNK11.89548713
16PASK1.85792710
17GRK11.84226372
18TXK1.81413418
19PDK31.75237274
20PDK41.75237274
21TEC1.73926665
22PNCK1.72708510
23INSRR1.69466302
24PRKD31.69078375
25NUAK11.66650214
26TLK11.64273930
27VRK21.59930843
28EPHB11.58382534
29MAP4K21.57327293
30MAP2K71.56893055
31MAP3K41.56626235
32PKN11.53484766
33LIMK11.51697381
34MARK11.47920973
35SGK2231.43597690
36SGK4941.43597690
37MAP3K91.39826328
38PAK61.39203575
39BCR1.34587477
40CAMK2B1.33925882
41MINK11.33542677
42MUSK1.33159832
43ARAF1.29799179
44VRK11.27088347
45CDK51.23105272
46ZAK1.21423834
47CSNK1G31.20456643
48CAMK2D1.19998238
49CSNK1G21.18648316
50MAP3K21.18088651
51WNK31.15644781
52GRK51.15583830
53STK161.14240573
54PRPF4B1.14222143
55MAPKAPK31.11670526
56KSR21.10776098
57ACVR1B1.10425613
58NEK61.09216972
59DAPK11.09211392
60SYK1.08367341
61MAPK151.07980684
62CAMK2A1.04006461
63PHKG21.03461349
64PHKG11.03461349
65PINK11.03023341
66TESK21.02220199
67MAP3K121.00230608
68MYLK0.98467802
69ICK0.96451497
70BTK0.93961643
71MAPK130.93054627
72FES0.91540356
73CSNK1A1L0.90689190
74CAMK2G0.90660098
75PDK20.89277845
76IRAK10.89102450
77MAP2K40.88494538
78BMPR1B0.87107764
79DAPK20.87040462
80MAP2K60.83503823
81NTRK20.83284637
82IKBKB0.82809052
83TNK20.82031984
84CDK140.81144021
85STK30.77761400
86MET0.77419644
87NME10.76743731
88ADRBK10.76722191
89CDK150.76343012
90PDPK10.75430412
91PLK30.75089076
92CDK180.74561984
93RIPK40.74366295
94TESK10.74086026
95CSNK1G10.73526320
96LMTK20.72453076
97ILK0.72431563
98GRK60.72017702
99ROCK20.71793202
100CAMKK20.71312328
101ITK0.70579502
102GRK70.69838742
103PDK10.69798527
104MARK20.69434223
105BRSK20.69238467
106PTK2B0.68475895
107CDK11A0.67807673
108PRKCE0.67628929
109PRKCG0.67289981
110IRAK20.66507078
111BMX0.65945393
112FGR0.64182905
113PAK30.63609194
114FGFR20.63501910
115DAPK30.62491506
116TRPM70.62063189
117TRIM280.61944893
118CSF1R0.60906856
119BRAF0.60714049
120HIPK20.60256470
121TAOK30.60179450
122ERBB30.59759354
123DYRK20.58744977
124ADRBK20.57800055
125PIK3CG0.57547335
126MAP3K10.57316409
127EIF2AK30.56442572
128PRKCQ0.56134753
129TYRO30.53119575
130TAF10.53048480
131STK40.52540481
132RET0.51593671
133FER0.51173562
134PLK20.49735985
135RPS6KA50.49262983
136PRKG10.48293209
137STK110.47896989
138PBK0.47155376
139PRKACA0.46441751
140PRKCA0.45998631
141LYN0.45544999
142PRKCH0.45243547
143BCKDK0.45015980
144CLK10.43943483
145BMPR20.43707722
146PRKCI0.42560246
147PRKACB0.41144367
148AKT30.40889820
149CAMK10.40429086
150IKBKE0.36078644
151CSNK1A10.35374225
152DYRK30.34816853
153CSNK2A20.33540037
154WEE10.32763508
155CDC70.31266132

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.84429039
2Fatty acid elongation_Homo sapiens_hsa000622.73370566
3Oxidative phosphorylation_Homo sapiens_hsa001902.60306481
4Synaptic vesicle cycle_Homo sapiens_hsa047212.37627139
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18784340
6Protein export_Homo sapiens_hsa030602.17205443
7Ribosome_Homo sapiens_hsa030102.15520719
8Sulfur metabolism_Homo sapiens_hsa009202.10967210
9Parkinsons disease_Homo sapiens_hsa050122.05162168
10Nicotine addiction_Homo sapiens_hsa050332.04279548
11Steroid biosynthesis_Homo sapiens_hsa001002.03612267
12GABAergic synapse_Homo sapiens_hsa047272.02971254
13Collecting duct acid secretion_Homo sapiens_hsa049661.89735805
14Alzheimers disease_Homo sapiens_hsa050101.87844678
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86935262
16RNA polymerase_Homo sapiens_hsa030201.86268885
17Glutamatergic synapse_Homo sapiens_hsa047241.84127526
18Insulin secretion_Homo sapiens_hsa049111.76305160
19Morphine addiction_Homo sapiens_hsa050321.75542073
20Circadian entrainment_Homo sapiens_hsa047131.75288780
21Homologous recombination_Homo sapiens_hsa034401.72236959
22Ether lipid metabolism_Homo sapiens_hsa005651.70406655
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66653190
24Amphetamine addiction_Homo sapiens_hsa050311.62706515
25Type I diabetes mellitus_Homo sapiens_hsa049401.61697811
26Vibrio cholerae infection_Homo sapiens_hsa051101.53937080
27Long-term potentiation_Homo sapiens_hsa047201.53721766
28Dopaminergic synapse_Homo sapiens_hsa047281.50613489
29Butanoate metabolism_Homo sapiens_hsa006501.50441204
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48688400
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48337415
32Serotonergic synapse_Homo sapiens_hsa047261.47935912
33Cardiac muscle contraction_Homo sapiens_hsa042601.46990978
34Vitamin B6 metabolism_Homo sapiens_hsa007501.45749799
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.43621603
36Proteasome_Homo sapiens_hsa030501.40911561
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40683586
38Cocaine addiction_Homo sapiens_hsa050301.40253918
39Taste transduction_Homo sapiens_hsa047421.39460409
40Phototransduction_Homo sapiens_hsa047441.39355612
41Olfactory transduction_Homo sapiens_hsa047401.35604218
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35310000
43Salivary secretion_Homo sapiens_hsa049701.33145412
44Huntingtons disease_Homo sapiens_hsa050161.29473346
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28417310
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28037895
47Nitrogen metabolism_Homo sapiens_hsa009101.27593634
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25150887
49Pyruvate metabolism_Homo sapiens_hsa006201.23918060
50Long-term depression_Homo sapiens_hsa047301.19444673
51Propanoate metabolism_Homo sapiens_hsa006401.18207056
52Gastric acid secretion_Homo sapiens_hsa049711.18141679
53Cholinergic synapse_Homo sapiens_hsa047251.17986893
54Mismatch repair_Homo sapiens_hsa034301.17227576
55One carbon pool by folate_Homo sapiens_hsa006701.15402773
56Renin secretion_Homo sapiens_hsa049241.15315510
57Pancreatic secretion_Homo sapiens_hsa049721.14619460
58Arachidonic acid metabolism_Homo sapiens_hsa005901.10732539
59Platelet activation_Homo sapiens_hsa046111.09381498
60Purine metabolism_Homo sapiens_hsa002301.06902409
61Histidine metabolism_Homo sapiens_hsa003401.05445502
62Folate biosynthesis_Homo sapiens_hsa007901.02874801
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01892415
64Tryptophan metabolism_Homo sapiens_hsa003800.98757989
65Fanconi anemia pathway_Homo sapiens_hsa034600.98546310
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96784404
67Pyrimidine metabolism_Homo sapiens_hsa002400.94342023
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94110601
69RNA degradation_Homo sapiens_hsa030180.92289646
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92007839
71Caffeine metabolism_Homo sapiens_hsa002320.91197958
72Calcium signaling pathway_Homo sapiens_hsa040200.88661492
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.85996003
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85939177
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85658714
76Sphingolipid metabolism_Homo sapiens_hsa006000.85610786
77Basal transcription factors_Homo sapiens_hsa030220.85090288
78Linoleic acid metabolism_Homo sapiens_hsa005910.84728935
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84219548
80Asthma_Homo sapiens_hsa053100.82188655
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81523794
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81517161
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79204958
84beta-Alanine metabolism_Homo sapiens_hsa004100.79013853
85Chemical carcinogenesis_Homo sapiens_hsa052040.77097639
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75145753
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74315127
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73992060
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.73072471
90Fatty acid metabolism_Homo sapiens_hsa012120.72926931
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72244908
92cAMP signaling pathway_Homo sapiens_hsa040240.71443993
93Type II diabetes mellitus_Homo sapiens_hsa049300.69195850
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68797505
95Glutathione metabolism_Homo sapiens_hsa004800.66228724
96Nucleotide excision repair_Homo sapiens_hsa034200.65794662
97Thyroid hormone synthesis_Homo sapiens_hsa049180.65067279
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.64719331
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64543596
100Circadian rhythm_Homo sapiens_hsa047100.64067661
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63063434
102Autoimmune thyroid disease_Homo sapiens_hsa053200.63017734
103Axon guidance_Homo sapiens_hsa043600.62527472
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62300211
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62293812
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62237262
107Oxytocin signaling pathway_Homo sapiens_hsa049210.61362596
108Rheumatoid arthritis_Homo sapiens_hsa053230.61178383
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60340272
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58828172
111Fatty acid biosynthesis_Homo sapiens_hsa000610.57879949
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.57830939
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.57789813
114Primary immunodeficiency_Homo sapiens_hsa053400.56482121
115Gap junction_Homo sapiens_hsa045400.56126266
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54951413
117Regulation of autophagy_Homo sapiens_hsa041400.54670514
118Mineral absorption_Homo sapiens_hsa049780.54510176
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54127240
120Dorso-ventral axis formation_Homo sapiens_hsa043200.53563561
121Hematopoietic cell lineage_Homo sapiens_hsa046400.51030506
122Arginine and proline metabolism_Homo sapiens_hsa003300.50406343
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49353822
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48246992
125Glycerolipid metabolism_Homo sapiens_hsa005610.47895875
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47419769
127Metabolic pathways_Homo sapiens_hsa011000.47275588
128ABC transporters_Homo sapiens_hsa020100.46195498
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46160365
130Allograft rejection_Homo sapiens_hsa053300.46061427
131GnRH signaling pathway_Homo sapiens_hsa049120.45260882
132Peroxisome_Homo sapiens_hsa041460.44625944
133Alcoholism_Homo sapiens_hsa050340.44246937
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41045337
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41018094
136Estrogen signaling pathway_Homo sapiens_hsa049150.40086858
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.39476844
138Glucagon signaling pathway_Homo sapiens_hsa049220.38506483
139Retinol metabolism_Homo sapiens_hsa008300.36840563
140Phagosome_Homo sapiens_hsa041450.36258056
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36130604
142Inositol phosphate metabolism_Homo sapiens_hsa005620.34138081
143* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33430088
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.33108383
145Endocytosis_Homo sapiens_hsa041440.33024466

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