SVOP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.39893441
2synaptic vesicle maturation (GO:0016188)6.04101035
3synaptic vesicle exocytosis (GO:0016079)5.74149142
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.71033201
5vocalization behavior (GO:0071625)5.65444287
6locomotory exploration behavior (GO:0035641)5.65406069
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.53545037
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52678726
9glutamate secretion (GO:0014047)5.17155104
10protein localization to synapse (GO:0035418)5.13842707
11regulation of glutamate receptor signaling pathway (GO:1900449)5.10879476
12regulation of synaptic vesicle exocytosis (GO:2000300)5.08424113
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.92434642
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.72233200
15exploration behavior (GO:0035640)4.66760252
16neuron cell-cell adhesion (GO:0007158)4.64462228
17regulation of neuronal synaptic plasticity (GO:0048168)4.58560447
18regulation of synaptic vesicle transport (GO:1902803)4.54896964
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49225344
20neurotransmitter secretion (GO:0007269)4.45125387
21regulation of synapse structural plasticity (GO:0051823)4.39521383
22layer formation in cerebral cortex (GO:0021819)4.34991472
23neuronal action potential propagation (GO:0019227)4.32297431
24synaptic transmission, glutamatergic (GO:0035249)4.27810997
25glutamate receptor signaling pathway (GO:0007215)4.23423384
26dendritic spine morphogenesis (GO:0060997)4.22728765
27synaptic vesicle endocytosis (GO:0048488)4.18176630
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15489104
29pyrimidine nucleobase catabolic process (GO:0006208)4.05029798
30neuron-neuron synaptic transmission (GO:0007270)4.04438690
31neurotransmitter-gated ion channel clustering (GO:0072578)4.03374034
32positive regulation of synapse maturation (GO:0090129)3.93903712
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91116265
34long-term memory (GO:0007616)3.88678296
35proline transport (GO:0015824)3.86522350
36gamma-aminobutyric acid transport (GO:0015812)3.82092528
37positive regulation of membrane potential (GO:0045838)3.81325799
38presynaptic membrane organization (GO:0097090)3.80952578
39cellular potassium ion homeostasis (GO:0030007)3.79830786
40presynaptic membrane assembly (GO:0097105)3.75824060
41neuron recognition (GO:0008038)3.75383310
42regulation of postsynaptic membrane potential (GO:0060078)3.74174045
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70290962
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69516616
45regulation of dendritic spine morphogenesis (GO:0061001)3.68279609
46behavioral response to nicotine (GO:0035095)3.67681321
47nucleobase catabolic process (GO:0046113)3.66258542
48regulation of synaptic plasticity (GO:0048167)3.63030892
49neuromuscular process controlling posture (GO:0050884)3.62518604
50neurotransmitter transport (GO:0006836)3.60434272
51neuromuscular process controlling balance (GO:0050885)3.56802315
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.54018117
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50939871
54neuromuscular synaptic transmission (GO:0007274)3.50517267
55regulation of neurotransmitter secretion (GO:0046928)3.49980600
56transmission of nerve impulse (GO:0019226)3.49728459
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.49022831
58cell migration in hindbrain (GO:0021535)3.46567930
59sodium ion export (GO:0071436)3.45806543
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.45689908
61axonal fasciculation (GO:0007413)3.43049913
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40133358
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39969749
64cerebellar Purkinje cell differentiation (GO:0021702)3.39742052
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.39293575
66activation of protein kinase A activity (GO:0034199)3.38775314
67long-term synaptic potentiation (GO:0060291)3.38217949
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37618418
69positive regulation of dendritic spine development (GO:0060999)3.34648980
70postsynaptic membrane organization (GO:0001941)3.34544485
71regulation of vesicle fusion (GO:0031338)3.33908977
72regulation of neurotransmitter levels (GO:0001505)3.30284426
73response to pheromone (GO:0019236)3.28706920
74regulation of voltage-gated calcium channel activity (GO:1901385)3.27616667
75auditory behavior (GO:0031223)3.26435011
76dendrite morphogenesis (GO:0048813)3.24351623
77startle response (GO:0001964)3.23965738
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23933208
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23790407
80cell communication by electrical coupling (GO:0010644)3.22366135
81positive regulation of neurotransmitter secretion (GO:0001956)3.21352026
82membrane depolarization (GO:0051899)3.21138055
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.21037235
84substrate-independent telencephalic tangential migration (GO:0021826)3.21037235
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21037134
86regulation of neurotransmitter transport (GO:0051588)3.20998540
87prepulse inhibition (GO:0060134)3.20991915
88behavioral fear response (GO:0001662)3.20531383
89behavioral defense response (GO:0002209)3.20531383
90establishment of mitochondrion localization (GO:0051654)3.18774133
91learning (GO:0007612)3.17652419
92response to auditory stimulus (GO:0010996)3.16728664
93membrane hyperpolarization (GO:0060081)3.16663101
94innervation (GO:0060384)3.16400069
95positive regulation of neurotransmitter transport (GO:0051590)3.16370122
96membrane depolarization during action potential (GO:0086010)3.14320678
97dendritic spine organization (GO:0097061)3.13415138
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13231372
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13043455
100glycine transport (GO:0015816)3.12184424
101regulation of dendritic spine development (GO:0060998)3.10266410
102cerebellar granule cell differentiation (GO:0021707)3.09259480
103neurofilament cytoskeleton organization (GO:0060052)3.09039366
104neuromuscular process (GO:0050905)3.08964064
105serotonin metabolic process (GO:0042428)3.07146322
106axon ensheathment in central nervous system (GO:0032291)3.06870998
107central nervous system myelination (GO:0022010)3.06870998
108response to histamine (GO:0034776)3.06372426
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05324408
110regulation of synapse maturation (GO:0090128)3.03995421
111synapse assembly (GO:0007416)3.03529048
112regulation of synaptic transmission (GO:0050804)3.03079544
113neuronal ion channel clustering (GO:0045161)3.02514487
114fear response (GO:0042596)3.00604126
115synaptic transmission (GO:0007268)3.00541782
116positive regulation of synaptic transmission (GO:0050806)2.99553230
117intraspecies interaction between organisms (GO:0051703)2.98360509
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.97501722
119primary amino compound metabolic process (GO:1901160)2.95521271
120mechanosensory behavior (GO:0007638)2.92966283
121behavioral response to cocaine (GO:0048148)2.91604294
122potassium ion homeostasis (GO:0055075)2.88859252
123calcium ion-dependent exocytosis (GO:0017156)2.87634776
124adult walking behavior (GO:0007628)2.86451756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12866078
2GBX2_23144817_ChIP-Seq_PC3_Human3.28848710
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16459766
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11328589
5REST_21632747_ChIP-Seq_MESCs_Mouse3.07604680
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02888729
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.82973043
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79152940
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76553039
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76553039
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.63791335
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57128914
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55822250
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54813177
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53604796
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.53057882
17DROSHA_22980978_ChIP-Seq_HELA_Human2.49934673
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46571693
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43428126
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.36024704
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33719952
22* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29953030
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.27287305
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.26162542
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25590465
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23389234
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04146016
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.01351826
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92090678
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81951273
31AR_21572438_ChIP-Seq_LNCaP_Human1.76657315
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65371578
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.60574264
34VDR_22108803_ChIP-Seq_LS180_Human1.58029659
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54530835
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.46678266
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43936479
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42346364
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.39592723
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38719421
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38512083
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38193484
43ZNF274_21170338_ChIP-Seq_K562_Hela1.37629393
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.32916564
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32692584
46TAF15_26573619_Chip-Seq_HEK293_Human1.32164097
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26974792
48KDM2B_26808549_Chip-Seq_K562_Human1.26402529
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.25471628
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24686049
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22927472
52FUS_26573619_Chip-Seq_HEK293_Human1.21341591
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.21210090
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21133827
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18691742
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18313824
57RNF2_27304074_Chip-Seq_NSC_Mouse1.18187365
58* AR_19668381_ChIP-Seq_PC3_Human1.17140957
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17086145
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13734187
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13209792
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11387185
63P300_19829295_ChIP-Seq_ESCs_Human1.11210776
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10733224
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09616584
66AR_25329375_ChIP-Seq_VCAP_Human1.09479035
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.09408375
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08642963
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08594361
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07864157
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07254473
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05696795
73CTCF_27219007_Chip-Seq_Bcells_Human1.05656214
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05116211
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03172997
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03084755
77* STAT3_23295773_ChIP-Seq_U87_Human1.02905547
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02806312
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02568538
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02475772
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.02390902
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02308074
83* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01282849
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00483135
85* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00411978
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00053909
87ER_23166858_ChIP-Seq_MCF-7_Human0.98528544
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97915298
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97592094
90CBP_20019798_ChIP-Seq_JUKART_Human0.97592094
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.95611679
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95427834
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95376202
94TCF4_23295773_ChIP-Seq_U87_Human0.93957424
95IGF1R_20145208_ChIP-Seq_DFB_Human0.93793847
96* TP53_20018659_ChIP-ChIP_R1E_Mouse0.93112986
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.93000929
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.92223604
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92178415
100BCAT_22108803_ChIP-Seq_LS180_Human0.91867132
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91828749
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91637052
103* TP53_22573176_ChIP-Seq_HFKS_Human0.91317445
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90843363
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90073968
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89750618
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89713506
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89524086
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89479729
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89376024
111JUN_21703547_ChIP-Seq_K562_Human0.88800985
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.88748305
113* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88538166
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.87788604
115AHR_22903824_ChIP-Seq_MCF-7_Human0.86217736
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.85688363
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85122565
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.84533890
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84454711
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83559751
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82684153
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.81977026
123RUNX2_22187159_ChIP-Seq_PCA_Human0.81436716
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.80943533
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80591834
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80227883
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80227883
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78687517
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78014487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61134791
2MP0003880_abnormal_central_pattern4.78122501
3MP0003635_abnormal_synaptic_transmissio4.21347063
4MP0004270_analgesia3.57286511
5MP0002063_abnormal_learning/memory/cond3.50301874
6MP0009745_abnormal_behavioral_response3.38851226
7MP0002064_seizures3.16267261
8MP0009046_muscle_twitch3.09678184
9MP0001968_abnormal_touch/_nociception2.95797732
10MP0002572_abnormal_emotion/affect_behav2.90437751
11MP0002822_catalepsy2.88031823
12MP0005423_abnormal_somatic_nervous2.82502123
13MP0002734_abnormal_mechanical_nocicepti2.55814844
14MP0002272_abnormal_nervous_system2.53463277
15MP0001486_abnormal_startle_reflex2.50455622
16MP0002736_abnormal_nociception_after2.26356843
17MP0002733_abnormal_thermal_nociception2.19063994
18MP0001501_abnormal_sleep_pattern2.15467198
19MP0002735_abnormal_chemical_nociception2.11394647
20MP0001440_abnormal_grooming_behavior2.09381068
21MP0001970_abnormal_pain_threshold2.07328334
22MP0000778_abnormal_nervous_system2.00408316
23MP0002184_abnormal_innervation1.96750831
24MP0002067_abnormal_sensory_capabilities1.93365502
25MP0004811_abnormal_neuron_physiology1.90353634
26MP0006276_abnormal_autonomic_nervous1.87247863
27MP0008569_lethality_at_weaning1.80493030
28MP0002557_abnormal_social/conspecific_i1.79303312
29MP0004858_abnormal_nervous_system1.77020431
30MP0003329_amyloid_beta_deposits1.73356187
31MP0004924_abnormal_behavior1.73052866
32MP0005386_behavior/neurological_phenoty1.73052866
33MP0005645_abnormal_hypothalamus_physiol1.71089320
34MP0008877_abnormal_DNA_methylation1.70730365
35MP0001984_abnormal_olfaction1.70348940
36MP0002909_abnormal_adrenal_gland1.69885017
37MP0000955_abnormal_spinal_cord1.68558380
38MP0005646_abnormal_pituitary_gland1.65068063
39MP0009780_abnormal_chondrocyte_physiolo1.64850177
40MP0002882_abnormal_neuron_morphology1.52748980
41MP0001529_abnormal_vocalization1.49523128
42MP0001502_abnormal_circadian_rhythm1.48400035
43MP0003879_abnormal_hair_cell1.45706073
44MP0002066_abnormal_motor_capabilities/c1.45677859
45MP0003121_genomic_imprinting1.43916313
46MP0004142_abnormal_muscle_tone1.40158669
47MP0003122_maternal_imprinting1.40036075
48MP0001986_abnormal_taste_sensitivity1.33684622
49MP0003787_abnormal_imprinting1.33267777
50MP0003633_abnormal_nervous_system1.29528381
51MP0004885_abnormal_endolymph1.28159663
52MP0003123_paternal_imprinting1.21796147
53MP0002152_abnormal_brain_morphology1.19584386
54MP0001905_abnormal_dopamine_level1.19010947
55MP0001485_abnormal_pinna_reflex1.17980750
56MP0002102_abnormal_ear_morphology1.16516104
57MP0005551_abnormal_eye_electrophysiolog1.16326021
58MP0003283_abnormal_digestive_organ1.13563948
59MP0004233_abnormal_muscle_weight1.13167156
60MP0003631_nervous_system_phenotype1.09357972
61MP0002876_abnormal_thyroid_physiology1.07687128
62MP0000751_myopathy1.07133335
63MP0004147_increased_porphyrin_level1.03072938
64MP0005499_abnormal_olfactory_system0.99929901
65MP0005394_taste/olfaction_phenotype0.99929901
66MP0002069_abnormal_eating/drinking_beha0.98294950
67MP0000569_abnormal_digit_pigmentation0.98120692
68MP0002229_neurodegeneration0.96700278
69MP0001188_hyperpigmentation0.96131184
70MP0008872_abnormal_physiological_respon0.93086151
71MP0004145_abnormal_muscle_electrophysio0.92747135
72MP0010386_abnormal_urinary_bladder0.92667025
73MP0006072_abnormal_retinal_apoptosis0.90508091
74MP0002752_abnormal_somatic_nervous0.86582676
75MP0003075_altered_response_to0.85135955
76MP0003634_abnormal_glial_cell0.84769023
77MP0000631_abnormal_neuroendocrine_gland0.84688077
78MP0008874_decreased_physiological_sensi0.83178546
79MP0004133_heterotaxia0.82312372
80MP0006292_abnormal_olfactory_placode0.79009976
81MP0003137_abnormal_impulse_conducting0.77603015
82MP0004043_abnormal_pH_regulation0.77088419
83MP0001963_abnormal_hearing_physiology0.75959410
84MP0008961_abnormal_basal_metabolism0.74890269
85MP0000013_abnormal_adipose_tissue0.74470005
86MP0001177_atelectasis0.74326496
87MP0004742_abnormal_vestibular_system0.74151444
88MP0005535_abnormal_body_temperature0.74028581
89MP0002653_abnormal_ependyma_morphology0.72790358
90MP0002090_abnormal_vision0.72499796
91MP0005171_absent_coat_pigmentation0.72413705
92MP0004085_abnormal_heartbeat0.72080299
93MP0000026_abnormal_inner_ear0.71945203
94MP0003632_abnormal_nervous_system0.71253330
95MP0002638_abnormal_pupillary_reflex0.70946142
96MP0003861_abnormal_nervous_system0.70334325
97MP0000920_abnormal_myelination0.69368574
98MP0003195_calcinosis0.67407433
99MP0002928_abnormal_bile_duct0.67008217
100MP0008875_abnormal_xenobiotic_pharmacok0.66595580
101MP0000604_amyloidosis0.65887728
102MP0003172_abnormal_lysosome_physiology0.65761682
103MP0005187_abnormal_penis_morphology0.65399467
104MP0005253_abnormal_eye_physiology0.63524037
105MP0001943_abnormal_respiration0.61050026
106MP0010769_abnormal_survival0.58598459
107MP0005623_abnormal_meninges_morphology0.58494886
108MP0008995_early_reproductive_senescence0.57929925
109MP0001664_abnormal_digestion0.57602999
110MP0002234_abnormal_pharynx_morphology0.57319187
111MP0002837_dystrophic_cardiac_calcinosis0.56686064
112MP0010768_mortality/aging0.56147811
113MP0010770_preweaning_lethality0.56050747
114MP0002082_postnatal_lethality0.56050747
115MP0005167_abnormal_blood-brain_barrier0.54718585
116MP0005195_abnormal_posterior_eye0.54281290
117MP0003956_abnormal_body_size0.53935279
118MP0002751_abnormal_autonomic_nervous0.53525563
119MP0003690_abnormal_glial_cell0.51069853
120MP0004215_abnormal_myocardial_fiber0.49781268

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.22041996
2Focal motor seizures (HP:0011153)7.13917026
3Focal seizures (HP:0007359)5.48526546
4Visual hallucinations (HP:0002367)5.42135659
5Epileptic encephalopathy (HP:0200134)4.94870496
6Febrile seizures (HP:0002373)4.70687428
7Atonic seizures (HP:0010819)4.65619538
8Progressive cerebellar ataxia (HP:0002073)4.31580851
9Absence seizures (HP:0002121)4.16979040
10Action tremor (HP:0002345)3.78935689
11Dialeptic seizures (HP:0011146)3.76419777
12Generalized tonic-clonic seizures (HP:0002069)3.64923356
13Ankle clonus (HP:0011448)3.62028402
14Supranuclear gaze palsy (HP:0000605)3.59779720
15Impaired vibration sensation in the lower limbs (HP:0002166)3.35702606
16Broad-based gait (HP:0002136)3.33586118
17Poor eye contact (HP:0000817)3.23095788
18Mutism (HP:0002300)3.22649067
19Abnormality of the lower motor neuron (HP:0002366)3.21963411
20Dysdiadochokinesis (HP:0002075)3.18336612
21Urinary bladder sphincter dysfunction (HP:0002839)3.18136363
22Depression (HP:0000716)3.14347076
23Gaze-evoked nystagmus (HP:0000640)3.09598861
24Abnormal eating behavior (HP:0100738)3.03772674
25Amblyopia (HP:0000646)2.97380180
26Impaired social interactions (HP:0000735)2.92692227
27Abnormal social behavior (HP:0012433)2.92692227
28Dysmetria (HP:0001310)2.89915377
29Truncal ataxia (HP:0002078)2.89110589
30Anxiety (HP:0000739)2.87988963
31Annular pancreas (HP:0001734)2.83926772
32Postural instability (HP:0002172)2.77785536
33Hemiparesis (HP:0001269)2.75191756
34Genetic anticipation (HP:0003743)2.72452859
35Urinary urgency (HP:0000012)2.66767511
36Excessive salivation (HP:0003781)2.63886853
37Drooling (HP:0002307)2.63886853
38Papilledema (HP:0001085)2.63373500
39Impaired smooth pursuit (HP:0007772)2.62478968
40Torticollis (HP:0000473)2.61243278
41Polyphagia (HP:0002591)2.60696245
42Spastic gait (HP:0002064)2.60082818
43Hyperventilation (HP:0002883)2.58933267
44Congenital stationary night blindness (HP:0007642)2.58720981
45Cerebral hypomyelination (HP:0006808)2.54764277
46Fetal akinesia sequence (HP:0001989)2.53206713
47Epileptiform EEG discharges (HP:0011182)2.47035711
48Focal dystonia (HP:0004373)2.44974087
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.41566131
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41566131
51Limb dystonia (HP:0002451)2.40395776
52EEG with generalized epileptiform discharges (HP:0011198)2.37082135
53Cerebral inclusion bodies (HP:0100314)2.37016408
54Bradykinesia (HP:0002067)2.36155867
55Intention tremor (HP:0002080)2.35363832
56Morphological abnormality of the pyramidal tract (HP:0002062)2.33988612
57Abnormality of binocular vision (HP:0011514)2.31195562
58Diplopia (HP:0000651)2.31195562
59Progressive inability to walk (HP:0002505)2.31095182
60Neurofibrillary tangles (HP:0002185)2.29949128
61Abnormality of ocular smooth pursuit (HP:0000617)2.28940320
62Medial flaring of the eyebrow (HP:0010747)2.28329872
63Abnormality of midbrain morphology (HP:0002418)2.27772664
64Molar tooth sign on MRI (HP:0002419)2.27772664
65Ventricular fibrillation (HP:0001663)2.26854955
66Stereotypic behavior (HP:0000733)2.24614997
67Hemiplegia (HP:0002301)2.24257131
68Hypsarrhythmia (HP:0002521)2.23368518
69Failure to thrive in infancy (HP:0001531)2.22418333
70Scanning speech (HP:0002168)2.21507056
71Impaired vibratory sensation (HP:0002495)2.21390114
72Lower limb muscle weakness (HP:0007340)2.20597735
73Spastic tetraplegia (HP:0002510)2.20326371
74Lissencephaly (HP:0001339)2.19544078
75Craniofacial dystonia (HP:0012179)2.17907158
76Status epilepticus (HP:0002133)2.17883864
77Megalencephaly (HP:0001355)2.17383629
78Insidious onset (HP:0003587)2.17238348
79Termporal pattern (HP:0011008)2.17238348
80Gait imbalance (HP:0002141)2.15194106
81Abnormality of the corticospinal tract (HP:0002492)2.14746404
82Agitation (HP:0000713)2.14489627
83Pheochromocytoma (HP:0002666)2.13058014
84Dysmetric saccades (HP:0000641)2.12034385
85Amyotrophic lateral sclerosis (HP:0007354)2.10128783
86Pancreatic cysts (HP:0001737)2.09561433
87Nephrogenic diabetes insipidus (HP:0009806)2.09112903
88Absent speech (HP:0001344)2.08360397
89Specific learning disability (HP:0001328)2.07273117
90Type II lissencephaly (HP:0007260)2.04281665
91CNS hypomyelination (HP:0003429)2.03558876
92Muscular hypotonia of the trunk (HP:0008936)2.03006418
93True hermaphroditism (HP:0010459)2.02786754
94Incomplete penetrance (HP:0003829)2.01951070
95Clonus (HP:0002169)2.00661432
96Pointed chin (HP:0000307)1.99906459
97Nephronophthisis (HP:0000090)1.99737238
98Generalized myoclonic seizures (HP:0002123)1.99159233
99Abnormality of the labia minora (HP:0012880)1.98999227
100Pancreatic fibrosis (HP:0100732)1.98880423
101Insomnia (HP:0100785)1.98673703
102Retinal dysplasia (HP:0007973)1.98087629
103Obstructive sleep apnea (HP:0002870)1.96257195
104Delusions (HP:0000746)1.95918509
105Protruding tongue (HP:0010808)1.94383731
106Inability to walk (HP:0002540)1.93019757
107Sleep apnea (HP:0010535)1.87793295
108Abnormal EKG (HP:0003115)1.85813625
109Pachygyria (HP:0001302)1.83119470
110Akinesia (HP:0002304)1.82191979
111Spastic tetraparesis (HP:0001285)1.80683465
112Hypomagnesemia (HP:0002917)1.78925506
113Hypoplasia of the corpus callosum (HP:0002079)1.78121586
114Narrow nasal bridge (HP:0000446)1.77118761
115Neuroendocrine neoplasm (HP:0100634)1.76831516
116Neuronal loss in central nervous system (HP:0002529)1.76669256
117Polydipsia (HP:0001959)1.74958461
118Abnormal drinking behavior (HP:0030082)1.74958461
119Dyskinesia (HP:0100660)1.74877124
120Gait ataxia (HP:0002066)1.74344629
121Rapidly progressive (HP:0003678)1.71909283
122Hypoventilation (HP:0002791)1.70391521
123Abnormality of salivation (HP:0100755)1.69452372
124Apathy (HP:0000741)1.68356190
125Congenital primary aphakia (HP:0007707)1.68048324
126Hypercortisolism (HP:0001578)1.67101954
127Poor suck (HP:0002033)1.67080432
128Psychosis (HP:0000709)1.66901334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.29043340
2NTRK34.12834453
3MAP3K94.02740412
4MARK13.29447764
5MAP3K42.83909608
6MINK12.68943286
7DAPK22.43825266
8PAK62.34415041
9MAP2K72.24478467
10NTRK22.22824951
11FRK2.08788748
12DAPK12.03270337
13PRKD32.01558794
14KSR21.99926426
15MAP4K21.79463569
16MAP3K121.73681650
17KSR11.69071859
18PRPF4B1.68679396
19UHMK11.64924883
20NTRK11.64535085
21TYRO31.63508214
22CAMKK11.61691038
23CASK1.61070013
24MAP2K41.57680987
25CDK51.56301594
26ARAF1.49778825
27RIPK41.48796713
28SIK21.48409491
29ICK1.37355550
30GRK51.37155174
31PINK11.32149806
32PLK21.31429650
33STK381.30263347
34MAPK131.27504188
35PHKG21.25984923
36PHKG11.25984923
37CDK191.21529418
38PRKCG1.18133347
39WNK41.13851757
40MAP3K61.12688693
41TNIK1.12643166
42LATS21.10247372
43FES1.06486480
44ADRBK21.05219591
45DDR21.00216197
46CDK181.00164828
47MAP3K130.99974058
48CAMK2A0.98652916
49CDK150.97321394
50CDK140.93491505
51TRIM280.92484286
52PNCK0.92306036
53FGR0.91881662
54RAF10.89321467
55WNK30.86911703
56CDK11A0.85997006
57MAP3K20.83881852
58CAMK2B0.83051614
59CAMKK20.82426618
60TAOK10.82054198
61BMPR1B0.81884258
62CAMK10.81539669
63MARK20.80953943
64STK110.77213990
65PKN10.74882644
66DYRK1A0.74785456
67BCR0.74464534
68CSNK1G30.73776954
69STK390.73477970
70SGK2230.70318363
71SGK4940.70318363
72PRKCH0.70182819
73GRK10.69841664
74PTK2B0.66266970
75LIMK10.66174155
76PAK30.65938262
77SGK10.65673875
78SIK30.65550610
79CSNK1A1L0.65544767
80TNK20.65289882
81ALK0.64480345
82CDC42BPA0.63542458
83PRKD20.63031028
84PRKCZ0.62649816
85CSNK1G10.60797817
86RET0.60130029
87MAP2K60.57853767
88CSNK1G20.56042357
89BMPR20.55277158
90FGFR20.55258004
91LMTK20.54336583
92NEK10.51902478
93RPS6KA30.48013656
94ADRBK10.47511903
95MAPK100.47049984
96PRKACA0.46530954
97OXSR10.45898211
98ERBB30.45804815
99SGK20.45017597
100PDK10.44287147
101CAMK2D0.44041408
102NME10.43430196
103CAMK2G0.43307395
104PDPK10.43291784
105MAP3K10.43107817
106PRKCA0.42417657
107CAMK40.42067544
108PRKAA10.42003170
109SGK30.41210965
110PRKCE0.40835369
111AKT30.40793346
112MATK0.39924148
113INSRR0.39619977
114FER0.39600727
115CSNK1A10.38985099
116CCNB10.38543075
117FYN0.38435385
118EPHA30.37718684
119RIPK10.36992888
120MAPK120.36017194
121CSNK1D0.35976414
122DYRK20.35610632
123BRAF0.35461625
124DAPK30.35324798
125BRSK10.35307454
126PRKG10.34172182
127CSNK1E0.33853923
128MAPKAPK50.31229115
129PRKCB0.28065725
130ERBB20.27797504
131PRKCQ0.25978776
132DYRK1B0.25974099
133CAMK1D0.25818407

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92781908
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54959332
3Olfactory transduction_Homo sapiens_hsa047402.88582250
4GABAergic synapse_Homo sapiens_hsa047272.84218287
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71790856
6Circadian entrainment_Homo sapiens_hsa047132.67741531
7Morphine addiction_Homo sapiens_hsa050322.58885928
8Glutamatergic synapse_Homo sapiens_hsa047242.57012103
9Long-term potentiation_Homo sapiens_hsa047202.54572621
10Amphetamine addiction_Homo sapiens_hsa050312.42165990
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26259753
12Dopaminergic synapse_Homo sapiens_hsa047282.21719475
13Salivary secretion_Homo sapiens_hsa049702.08536597
14Insulin secretion_Homo sapiens_hsa049112.02979206
15Cholinergic synapse_Homo sapiens_hsa047251.92831766
16Taste transduction_Homo sapiens_hsa047421.78299366
17Gastric acid secretion_Homo sapiens_hsa049711.77813238
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75664834
19Oxytocin signaling pathway_Homo sapiens_hsa049211.69312565
20Serotonergic synapse_Homo sapiens_hsa047261.68781244
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68001589
22Long-term depression_Homo sapiens_hsa047301.65267283
23Cocaine addiction_Homo sapiens_hsa050301.61309140
24Renin secretion_Homo sapiens_hsa049241.60081024
25Collecting duct acid secretion_Homo sapiens_hsa049661.54287101
26Calcium signaling pathway_Homo sapiens_hsa040201.53291822
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50369542
28GnRH signaling pathway_Homo sapiens_hsa049121.47829603
29Gap junction_Homo sapiens_hsa045401.46434092
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34772254
31Oxidative phosphorylation_Homo sapiens_hsa001901.34180926
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.30994345
33Butanoate metabolism_Homo sapiens_hsa006501.30008176
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29821617
35cAMP signaling pathway_Homo sapiens_hsa040241.20620739
36Axon guidance_Homo sapiens_hsa043601.17865111
37Estrogen signaling pathway_Homo sapiens_hsa049151.13667299
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12361359
39Phototransduction_Homo sapiens_hsa047441.10468913
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09630746
41Glioma_Homo sapiens_hsa052141.09071051
42Type II diabetes mellitus_Homo sapiens_hsa049301.08983475
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08737947
44ErbB signaling pathway_Homo sapiens_hsa040121.08457593
45Cardiac muscle contraction_Homo sapiens_hsa042601.08196539
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07289513
47Melanogenesis_Homo sapiens_hsa049161.01512522
48Oocyte meiosis_Homo sapiens_hsa041141.00661115
49Vibrio cholerae infection_Homo sapiens_hsa051100.96902559
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96498343
51Parkinsons disease_Homo sapiens_hsa050120.96342434
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95919461
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92809043
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87405640
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.82449810
56Vitamin B6 metabolism_Homo sapiens_hsa007500.81593168
57Dorso-ventral axis formation_Homo sapiens_hsa043200.80177942
58Choline metabolism in cancer_Homo sapiens_hsa052310.80165613
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79573860
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.79501451
61Regulation of autophagy_Homo sapiens_hsa041400.78089754
62VEGF signaling pathway_Homo sapiens_hsa043700.74615165
63Ether lipid metabolism_Homo sapiens_hsa005650.74555549
64MAPK signaling pathway_Homo sapiens_hsa040100.73690942
65mTOR signaling pathway_Homo sapiens_hsa041500.72966014
66Circadian rhythm_Homo sapiens_hsa047100.72563365
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72369620
68Pancreatic secretion_Homo sapiens_hsa049720.70946104
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70852398
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70479459
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70082494
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68045298
73Dilated cardiomyopathy_Homo sapiens_hsa054140.67135076
74Thyroid hormone synthesis_Homo sapiens_hsa049180.66716661
75Linoleic acid metabolism_Homo sapiens_hsa005910.66234614
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.61838897
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59094545
78Fatty acid biosynthesis_Homo sapiens_hsa000610.58755490
79Alcoholism_Homo sapiens_hsa050340.57557426
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56475180
81Ras signaling pathway_Homo sapiens_hsa040140.56203103
82Glucagon signaling pathway_Homo sapiens_hsa049220.55572257
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54298349
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54120302
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53929561
86Wnt signaling pathway_Homo sapiens_hsa043100.53237936
87beta-Alanine metabolism_Homo sapiens_hsa004100.52938076
88Rap1 signaling pathway_Homo sapiens_hsa040150.51876752
89Endocytosis_Homo sapiens_hsa041440.51809159
90Endometrial cancer_Homo sapiens_hsa052130.51522703
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.51267077
92Huntingtons disease_Homo sapiens_hsa050160.49864374
93Type I diabetes mellitus_Homo sapiens_hsa049400.47908580
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45380495
95Insulin signaling pathway_Homo sapiens_hsa049100.45080549
96Prion diseases_Homo sapiens_hsa050200.44834815
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44265083
98Nitrogen metabolism_Homo sapiens_hsa009100.43804225
99Mineral absorption_Homo sapiens_hsa049780.41385123
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41167291
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41163394
102Inositol phosphate metabolism_Homo sapiens_hsa005620.40854128
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40828406
104Tryptophan metabolism_Homo sapiens_hsa003800.38964276
105Non-small cell lung cancer_Homo sapiens_hsa052230.38831553
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37789388
107Colorectal cancer_Homo sapiens_hsa052100.36244724
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36105112
109Histidine metabolism_Homo sapiens_hsa003400.35766551
110Protein export_Homo sapiens_hsa030600.35586676
111Bile secretion_Homo sapiens_hsa049760.34539173
112Renal cell carcinoma_Homo sapiens_hsa052110.33838334
113Hedgehog signaling pathway_Homo sapiens_hsa043400.32234493
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31701651
115Alzheimers disease_Homo sapiens_hsa050100.31659713
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30990099
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30698524
118ABC transporters_Homo sapiens_hsa020100.29996728
119Arginine and proline metabolism_Homo sapiens_hsa003300.29362258
120Chemokine signaling pathway_Homo sapiens_hsa040620.29141561
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28218536
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27203347
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26148698
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26069874
125Ovarian steroidogenesis_Homo sapiens_hsa049130.24606785
126Propanoate metabolism_Homo sapiens_hsa006400.22943453

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