SVOPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1uronic acid metabolic process (GO:0006063)8.41211229
2glucuronate metabolic process (GO:0019585)8.41211229
3regulation of DNA methylation (GO:0044030)7.66893530
4regulation of acrosome reaction (GO:0060046)7.64645841
5cellular glucuronidation (GO:0052695)7.44284125
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)7.00686566
7purine ribonucleoside bisphosphate metabolic process (GO:0034035)7.00686566
8phenylpropanoid metabolic process (GO:0009698)6.90898264
9sulfation (GO:0051923)6.58831137
10piRNA metabolic process (GO:0034587)6.53816633
11positive regulation of histone H3-K4 methylation (GO:0051571)6.37241900
12regulation of meiosis I (GO:0060631)6.23635735
13multicellular organism reproduction (GO:0032504)5.98442825
14protein kinase C signaling (GO:0070528)5.93077919
15regulation of histone H3-K9 methylation (GO:0051570)5.85432219
16water-soluble vitamin biosynthetic process (GO:0042364)5.70879279
17meiotic cell cycle (GO:0051321)5.69057930
18regulation of chemokine secretion (GO:0090196)5.61045385
19DNA methylation involved in gamete generation (GO:0043046)5.52811868
20phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.41337330
21retinal cone cell development (GO:0046549)5.14872578
22aggressive behavior (GO:0002118)5.07829656
23oocyte development (GO:0048599)5.06483903
24pyrimidine-containing compound transmembrane transport (GO:0072531)5.04990107
25generation of neurons (GO:0048699)5.02373137
26female gamete generation (GO:0007292)4.83353500
27negative regulation of execution phase of apoptosis (GO:1900118)4.77699235
28glomerulus development (GO:0032835)4.70989993
29estrogen metabolic process (GO:0008210)4.67224631
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.61779254
31renal absorption (GO:0070293)4.53213051
32appendage development (GO:0048736)4.49708240
33limb development (GO:0060173)4.49708240
34centriole replication (GO:0007099)4.42318773
35citrulline biosynthetic process (GO:0019240)4.36981763
36regulation of steroid hormone secretion (GO:2000831)4.25685779
37nucleotide transmembrane transport (GO:1901679)4.25355021
38negative regulation of reproductive process (GO:2000242)4.24369329
39negative regulation of histone methylation (GO:0031061)4.19357562
40positive regulation of histone methylation (GO:0031062)4.18526378
41calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.15415659
42cell differentiation involved in metanephros development (GO:0072202)4.14154287
43translesion synthesis (GO:0019985)4.09543400
44primitive streak formation (GO:0090009)4.08760045
45polyketide metabolic process (GO:0030638)4.07519025
46doxorubicin metabolic process (GO:0044598)4.07519025
47daunorubicin metabolic process (GO:0044597)4.07519025
48reproduction (GO:0000003)4.04833527
49NAD biosynthetic process (GO:0009435)4.01389554
50regulation of female gonad development (GO:2000194)4.01134018
51negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.98620806
52metanephric mesenchyme development (GO:0072075)3.94395818
53dentate gyrus development (GO:0021542)3.92624420
54synapsis (GO:0007129)3.92211409
55pharyngeal system development (GO:0060037)3.89836128
56definitive hemopoiesis (GO:0060216)3.89458839
57xenobiotic catabolic process (GO:0042178)3.84120687
58gene silencing by RNA (GO:0031047)3.78542661
59regulation of lipoprotein metabolic process (GO:0050746)3.76541759
60centriole assembly (GO:0098534)3.75667362
61Notch signaling involved in heart development (GO:0061314)3.74640483
62fertilization (GO:0009566)3.74483446
63regulation of histone H3-K4 methylation (GO:0051569)3.68031524
64male meiosis I (GO:0007141)3.66126604
65regulation of female receptivity (GO:0045924)3.66044996
66glycine transport (GO:0015816)3.64962131
67energy homeostasis (GO:0097009)3.64224312
68DNA replication-dependent nucleosome assembly (GO:0006335)3.61296293
69DNA replication-dependent nucleosome organization (GO:0034723)3.61296293
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.60159075
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.60159075
72positive regulation of mitotic sister chromatid separation (GO:1901970)3.60159075
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.56539353
74hyperosmotic salinity response (GO:0042538)3.54405900
75pyridine nucleotide biosynthetic process (GO:0019363)3.52489034
76nicotinamide nucleotide biosynthetic process (GO:0019359)3.52489034
77pyrimidine nucleotide catabolic process (GO:0006244)3.52164165
78synaptonemal complex assembly (GO:0007130)3.51792034
79positive regulation of actin filament depolymerization (GO:0030836)3.47209845
80binding of sperm to zona pellucida (GO:0007339)3.47196331
81interkinetic nuclear migration (GO:0022027)3.44980453
82single fertilization (GO:0007338)3.43564778
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40962872
84chromosome organization involved in meiosis (GO:0070192)3.40730864
85kidney mesenchyme development (GO:0072074)3.39566993
86myoblast migration (GO:0051451)3.38903435
87negative regulation of lipase activity (GO:0060192)3.38258465
88relaxation of smooth muscle (GO:0044557)3.36975798
89ribosomal small subunit assembly (GO:0000028)3.34037189
90regulation of cell maturation (GO:1903429)3.33543902
91positive regulation of gastrulation (GO:2000543)3.32877798
92one-carbon compound transport (GO:0019755)3.32654732
93positive regulation of reproductive process (GO:2000243)3.29705234
94vitamin biosynthetic process (GO:0009110)3.29442183
95cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.29015490
96mitotic chromosome condensation (GO:0007076)3.21595355
97bone remodeling (GO:0046849)3.21122711
98positive regulation of humoral immune response (GO:0002922)3.19254591
99synaptonemal complex organization (GO:0070193)3.18430562
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.18406027
101regulation of hypersensitivity (GO:0002883)3.17559833
102regulation of meiosis (GO:0040020)3.16621013
103female mating behavior (GO:0060180)3.16057179
104DNA alkylation (GO:0006305)3.14661371
105DNA methylation (GO:0006306)3.14661371
106cilium or flagellum-dependent cell motility (GO:0001539)3.13421462
107citrulline metabolic process (GO:0000052)3.12936945
108regulation of secondary heart field cardioblast proliferation (GO:0003266)3.11986641
109regulation of cardioblast proliferation (GO:0003264)3.11986641
110positive regulation of cholesterol efflux (GO:0010875)3.08656648
111ethanol oxidation (GO:0006069)3.07169311
112sperm-egg recognition (GO:0035036)3.06832029
113male meiosis (GO:0007140)3.06769771
114positive regulation of chromosome segregation (GO:0051984)3.05374272
115regulation of chromatin silencing (GO:0031935)3.01671960
116deoxyribonucleotide catabolic process (GO:0009264)2.99696728
117proline biosynthetic process (GO:0006561)2.99421303
118deoxyribose phosphate catabolic process (GO:0046386)2.98241584
119negative regulation of homotypic cell-cell adhesion (GO:0034111)2.97887511
120response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.96203054
121positive regulation of microtubule polymerization (GO:0031116)2.95839770
122DNA integration (GO:0015074)2.94538620
123meiosis I (GO:0007127)2.93749562
124positive regulation of hormone biosynthetic process (GO:0046886)2.93332923
125CENP-A containing nucleosome assembly (GO:0034080)2.92926082
126regulation of histone methylation (GO:0031060)2.92917547
127meiotic nuclear division (GO:0007126)2.91338369
128polyol transport (GO:0015791)2.88624890
129establishment of epithelial cell polarity (GO:0090162)2.88075433
130deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87866716
131base-excision repair, AP site formation (GO:0006285)2.87273428
132ear development (GO:0043583)2.85780887
133organelle membrane fusion (GO:0090174)2.85069780
134negative regulation of hormone metabolic process (GO:0032351)2.84868500
135aminoglycoside antibiotic metabolic process (GO:0030647)2.84138548
136imidazole-containing compound metabolic process (GO:0052803)2.83853896
137superoxide anion generation (GO:0042554)2.82826453
138meiotic cell cycle process (GO:1903046)2.82488887
139regulation of reproductive process (GO:2000241)2.80784112
140sensory perception of smell (GO:0007608)2.80780976
141positive regulation of uterine smooth muscle contraction (GO:0070474)2.79735043
142postreplication repair (GO:0006301)2.78874420
143regulation of steroid hormone biosynthetic process (GO:0090030)2.78680696
144keratinocyte development (GO:0003334)2.78570171
145positive regulation of toll-like receptor signaling pathway (GO:0034123)2.78339269
146cell proliferation in forebrain (GO:0021846)2.78247791
147positive regulation of interleukin-8 secretion (GO:2000484)2.78245330
148positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.76800357
149protein localization to kinetochore (GO:0034501)2.76600764
150reciprocal meiotic recombination (GO:0007131)2.76294081
151reciprocal DNA recombination (GO:0035825)2.76294081
152hydrogen peroxide biosynthetic process (GO:0050665)2.75800584
153cellular ketone body metabolic process (GO:0046950)2.75776868
154regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.74749057
155aorta morphogenesis (GO:0035909)2.73948624
156pyridine-containing compound biosynthetic process (GO:0072525)2.72478488
157positive regulation of steroid hormone secretion (GO:2000833)2.70732132
158spermatid development (GO:0007286)2.70284899
159regulation of meiotic cell cycle (GO:0051445)2.69684624
160chromatin remodeling at centromere (GO:0031055)2.69392663
161inner ear morphogenesis (GO:0042472)2.69023869
162negative regulation of histone modification (GO:0031057)2.67631001
163regulation of mast cell activation involved in immune response (GO:0033006)2.66849308
164maternal behavior (GO:0042711)2.66746229
165regulation of platelet aggregation (GO:0090330)2.63379992
166cilium movement (GO:0003341)2.63098282
167urinary tract smooth muscle contraction (GO:0014848)2.62433507
168regulation of mesonephros development (GO:0061217)2.60555889
169replicative senescence (GO:0090399)2.59954611
170positive regulation of mesonephros development (GO:0061213)2.59610686
171regulation of keratinocyte proliferation (GO:0010837)2.58520498
172L-ascorbic acid metabolic process (GO:0019852)2.58404617
173interleukin-6-mediated signaling pathway (GO:0070102)2.57859908
174extracellular negative regulation of signal transduction (GO:1900116)2.57597407
175extracellular regulation of signal transduction (GO:1900115)2.57597407
176mesenchymal cell development (GO:0014031)2.57095265
177ureteric bud development (GO:0001657)2.56994930
178regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.56635102
179omega-hydroxylase P450 pathway (GO:0097267)2.56305832
180retina layer formation (GO:0010842)2.54175309
181cell differentiation involved in kidney development (GO:0061005)2.52550707
182thrombin receptor signaling pathway (GO:0070493)2.51806824
183negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51133302
184nucleoside bisphosphate metabolic process (GO:0033865)2.51075839
185purine nucleoside bisphosphate metabolic process (GO:0034032)2.51075839
186ribonucleoside bisphosphate metabolic process (GO:0033875)2.51075839
187positive regulation of sterol transport (GO:0032373)2.50235693
188positive regulation of cholesterol transport (GO:0032376)2.50235693
189transepithelial transport (GO:0070633)2.50181450
190kidney morphogenesis (GO:0060993)2.49637976
191neural crest cell development (GO:0014032)2.48157500
192secondary metabolic process (GO:0019748)2.47783459
193cranial nerve morphogenesis (GO:0021602)2.47125188
194alkaloid metabolic process (GO:0009820)2.47079101
195G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.46518881
196primary alcohol catabolic process (GO:0034310)2.45976267
197reactive oxygen species biosynthetic process (GO:1903409)2.45882027
198neurofilament cytoskeleton organization (GO:0060052)2.45641195
199protein localization to microtubule cytoskeleton (GO:0072698)2.44896185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80745754
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.65923109
3E2F7_22180533_ChIP-Seq_HELA_Human4.32326524
4GBX2_23144817_ChIP-Seq_PC3_Human4.26130498
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.91645479
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82290368
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42867462
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38832898
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33132406
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31581055
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28978213
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.28765409
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26630007
14FUS_26573619_Chip-Seq_HEK293_Human2.21545764
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19768761
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.11417387
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10560888
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06931731
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06881328
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.00657304
21SCL_19346495_ChIP-Seq_HPC-7_Human1.96672401
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.95192336
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95142240
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94171099
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91001820
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90859855
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.89916767
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89715782
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89688606
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88173062
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85936768
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.85827315
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84214548
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81558884
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81558884
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81558884
37TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.80473234
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78715827
39FOXP3_21729870_ChIP-Seq_TREG_Human1.78218291
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.77953049
41P300_19829295_ChIP-Seq_ESCs_Human1.77726128
42* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.75432112
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.71232634
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70687405
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68387311
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.67122489
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67085754
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66424036
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65940711
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65651497
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.62152209
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.61823907
53TP53_18474530_ChIP-ChIP_U2OS_Human1.61381429
54VDR_22108803_ChIP-Seq_LS180_Human1.61211550
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61028521
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60661301
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60661301
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60542731
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60347712
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60238582
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59327250
62IRF1_19129219_ChIP-ChIP_H3396_Human1.59233962
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.58912159
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.58483919
65AHR_22903824_ChIP-Seq_MCF-7_Human1.57599980
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.57448385
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55716540
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.55212349
69RNF2_27304074_Chip-Seq_NSC_Mouse1.53769043
70TAF15_26573619_Chip-Seq_HEK293_Human1.53670726
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53101620
72EZH2_22144423_ChIP-Seq_EOC_Human1.52285659
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51049502
74DROSHA_22980978_ChIP-Seq_HELA_Human1.49719775
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48449200
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48268486
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.47183170
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46199371
79ER_23166858_ChIP-Seq_MCF-7_Human1.44823646
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43917940
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.43890970
82SMAD4_21799915_ChIP-Seq_A2780_Human1.42963886
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41536685
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40245060
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40239092
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.40172794
87TP53_16413492_ChIP-PET_HCT116_Human1.39810792
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39325551
89MYC_18940864_ChIP-ChIP_HL60_Human1.39165775
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37960520
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.36909059
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34773774
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34162941
94P53_22387025_ChIP-Seq_ESCs_Mouse1.34132757
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32451529
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32451529
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32431607
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.31804070
99NANOG_20526341_ChIP-Seq_ESCs_Human1.31511200
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31235118
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.31102339
102VDR_23849224_ChIP-Seq_CD4+_Human1.30744524
103EWS_26573619_Chip-Seq_HEK293_Human1.30217682
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28731749
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26610391
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26591489
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25345738
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.25033178
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24795398
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.24500771
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24499261
112P300_18555785_Chip-Seq_ESCs_Mouse1.24445917
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23984072
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.23406624
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.22517826
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.22467434
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.22025060
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21782238
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21782238
120AR_25329375_ChIP-Seq_VCAP_Human1.21775313
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.21422034
122KDM2B_26808549_Chip-Seq_REH_Human1.20354845
123MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19341413
124MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19296277
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18643572
126AR_21572438_ChIP-Seq_LNCaP_Human1.18237434
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16876310
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16767216
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16626597
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16561817
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.16126225
132* STAT3_23295773_ChIP-Seq_U87_Human1.15441568
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15376588
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.15266367
135NOTCH1_21737748_ChIP-Seq_TLL_Human1.14572291
136ESR1_21235772_ChIP-Seq_MCF-7_Human1.14312354
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14096006
138CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13456538
139TP53_22573176_ChIP-Seq_HFKS_Human1.11728036
140GATA1_26923725_Chip-Seq_HPCs_Mouse1.11039877
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05256262
142CBP_20019798_ChIP-Seq_JUKART_Human1.05256262
143PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04748952
144AR_20517297_ChIP-Seq_VCAP_Human1.00801781
145E2F1_21310950_ChIP-Seq_MCF-7_Human1.00390776
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00170880
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.98486184
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98486184
149ZNF274_21170338_ChIP-Seq_K562_Hela0.96074421
150P300_27268052_Chip-Seq_Bcells_Human0.93737211
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93238032
152MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93020539
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92584838
154HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92552101
155GATA1_22025678_ChIP-Seq_K562_Human0.91568739
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89516873
157SRF_21415370_ChIP-Seq_HL-1_Mouse0.86330123
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.83904906
159GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82057787
160FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81295412
161SMRT_27268052_Chip-Seq_Bcells_Human0.81184677
162TCF4_23295773_ChIP-Seq_U87_Human0.80439093
163TTF2_22483619_ChIP-Seq_HELA_Human0.77855852
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.77622621
165ERA_21632823_ChIP-Seq_H3396_Human0.74164693
166GATA3_21878914_ChIP-Seq_MCF-7_Human0.74083359
167GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72879180
168MYC_19030024_ChIP-ChIP_MESCs_Mouse0.72438483
169LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72201737
170* SOX2_19829295_ChIP-Seq_ESCs_Human0.70145736
171* NANOG_19829295_ChIP-Seq_ESCs_Human0.70145736
172EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69866850
173SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69629300
174AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68995251
175E2F1_17053090_ChIP-ChIP_MCF-7_Human0.67977337
176BCL6_27268052_Chip-Seq_Bcells_Human0.67909947
177E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.67838625
178BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.67584186
179FOXM1_23109430_ChIP-Seq_U2OS_Human0.67380605
180CBP_21632823_ChIP-Seq_H3396_Human0.67360617
181PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.67024442
182RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.66771501
183THAP11_20581084_ChIP-Seq_MESCs_Mouse0.65989141
184NCOR_22424771_ChIP-Seq_293T_Human0.65862695
185YY1_22570637_ChIP-Seq_MALME-3M_Human0.64396174
186RAC3_21632823_ChIP-Seq_H3396_Human0.64338832
187TAF2_19829295_ChIP-Seq_ESCs_Human0.63255545
188ERG_20517297_ChIP-Seq_VCAP_Human0.63245043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium6.35098115
2MP0005394_taste/olfaction_phenotype6.34841662
3MP0005499_abnormal_olfactory_system6.34841662
4MP0010030_abnormal_orbit_morphology4.79214333
5MP0001984_abnormal_olfaction4.52509757
6MP0008877_abnormal_DNA_methylation4.02428214
7MP0002009_preneoplasia3.72099328
8MP0001346_abnormal_lacrimal_gland3.05347460
9MP0002277_abnormal_respiratory_mucosa3.04562811
10MP0003693_abnormal_embryo_hatching2.89297638
11MP0005395_other_phenotype2.77751090
12MP0002132_abnormal_respiratory_system2.72752356
13MP0005423_abnormal_somatic_nervous2.55246544
14MP0002233_abnormal_nose_morphology2.45746533
15MP0008875_abnormal_xenobiotic_pharmacok2.42269524
16MP0001188_hyperpigmentation2.25481879
17MP0005410_abnormal_fertilization2.24859576
18MP0003699_abnormal_female_reproductive2.24196266
19MP0002234_abnormal_pharynx_morphology2.22650443
20MP0010094_abnormal_chromosome_stability2.18335861
21MP0005646_abnormal_pituitary_gland2.16047888
22MP0001929_abnormal_gametogenesis2.15814286
23MP0006292_abnormal_olfactory_placode2.07735846
24MP0002139_abnormal_hepatobiliary_system2.01374891
25MP0001177_atelectasis1.98009910
26MP0009379_abnormal_foot_pigmentation1.95873159
27MP0000465_gastrointestinal_hemorrhage1.94426361
28MP0003183_abnormal_peptide_metabolism1.93484379
29MP0003878_abnormal_ear_physiology1.88335538
30MP0005377_hearing/vestibular/ear_phenot1.88335538
31MP0001545_abnormal_hematopoietic_system1.87830539
32MP0005397_hematopoietic_system_phenotyp1.87830539
33MP0008057_abnormal_DNA_replication1.82924131
34MP0002210_abnormal_sex_determination1.82166913
35MP0000049_abnormal_middle_ear1.80388156
36MP0005408_hypopigmentation1.80328417
37MP0003077_abnormal_cell_cycle1.75803180
38MP0005248_abnormal_Harderian_gland1.75559845
39MP0005075_abnormal_melanosome_morpholog1.74573835
40MP0010386_abnormal_urinary_bladder1.63374394
41MP0000372_irregular_coat_pigmentation1.60912517
42MP0004133_heterotaxia1.58429905
43MP0001485_abnormal_pinna_reflex1.56327230
44MP0000653_abnormal_sex_gland1.55802280
45MP0008995_early_reproductive_senescence1.54578103
46MP0001293_anophthalmia1.51971740
47MP0002161_abnormal_fertility/fecundity1.49491004
48MP0004381_abnormal_hair_follicle1.46102903
49MP0003755_abnormal_palate_morphology1.43471354
50MP0000534_abnormal_ureter_morphology1.43389367
51MP0003656_abnormal_erythrocyte_physiolo1.42134812
52MP0006276_abnormal_autonomic_nervous1.41978237
53MP0003937_abnormal_limbs/digits/tail_de1.41556595
54MP0003890_abnormal_embryonic-extraembry1.40039135
55MP0004270_analgesia1.37393929
56MP0001986_abnormal_taste_sensitivity1.36904603
57MP0000762_abnormal_tongue_morphology1.36140908
58MP0009780_abnormal_chondrocyte_physiolo1.36035817
59MP0003698_abnormal_male_reproductive1.33976109
60MP0009278_abnormal_bone_marrow1.32380377
61MP0001145_abnormal_male_reproductive1.31574422
62MP0002396_abnormal_hematopoietic_system1.31529903
63MP0003111_abnormal_nucleus_morphology1.30123808
64MP0005174_abnormal_tail_pigmentation1.29828518
65MP0002006_tumorigenesis1.28461828
66MP0009840_abnormal_foam_cell1.27661096
67MP0000613_abnormal_salivary_gland1.26929294
68MP0001664_abnormal_digestion1.25933593
69MP0002249_abnormal_larynx_morphology1.23544374
70MP0005464_abnormal_platelet_physiology1.23137957
71MP0004043_abnormal_pH_regulation1.20968706
72MP0005645_abnormal_hypothalamus_physiol1.20047135
73MP0005360_urolithiasis1.18730920
74MP0003136_yellow_coat_color1.18725795
75MP0002102_abnormal_ear_morphology1.16169258
76MP0003879_abnormal_hair_cell1.14273447
77MP0000566_synostosis1.13655731
78MP0005171_absent_coat_pigmentation1.09260542
79MP0000778_abnormal_nervous_system1.07333001
80MP0002734_abnormal_mechanical_nocicepti1.05281344
81MP0003942_abnormal_urinary_system1.03180195
82MP0001764_abnormal_homeostasis1.01114975
83MP0000026_abnormal_inner_ear1.01109882
84MP0003806_abnormal_nucleotide_metabolis0.99346244
85MP0000462_abnormal_digestive_system0.99196095
86MP0003121_genomic_imprinting0.98849477
87MP0009697_abnormal_copulation0.97901639
88MP0000631_abnormal_neuroendocrine_gland0.97338197
89MP0004147_increased_porphyrin_level0.96871176
90MP0005197_abnormal_uvea_morphology0.94444107
91MP0003385_abnormal_body_wall0.93180057
92MP0003252_abnormal_bile_duct0.92987972
93MP0004142_abnormal_muscle_tone0.91760270
94MP0001730_embryonic_growth_arrest0.90663456
95MP0009250_abnormal_appendicular_skeleto0.90324787
96MP0005451_abnormal_body_composition0.89577006
97MP0004957_abnormal_blastocyst_morpholog0.87719867
98MP0003786_premature_aging0.87301020
99MP0005310_abnormal_salivary_gland0.86747597
100MP0005551_abnormal_eye_electrophysiolog0.85307785
101MP0002735_abnormal_chemical_nociception0.85302945
102MP0003186_abnormal_redox_activity0.85120129
103MP0005367_renal/urinary_system_phenotyp0.84997634
104MP0000516_abnormal_urinary_system0.84997634
105MP0005647_abnormal_sex_gland0.84518399
106MP0002019_abnormal_tumor_incidence0.83188930
107MP0002116_abnormal_craniofacial_bone0.82075935
108MP0000015_abnormal_ear_pigmentation0.81909447
109MP0001919_abnormal_reproductive_system0.81589941
110MP0001963_abnormal_hearing_physiology0.80408854
111MP0003880_abnormal_central_pattern0.79359828
112MP0010307_abnormal_tumor_latency0.79278318
113MP0004742_abnormal_vestibular_system0.79152729
114MP0002177_abnormal_outer_ear0.78296871
115MP0004134_abnormal_chest_morphology0.78103146
116MP0004808_abnormal_hematopoietic_stem0.72923633
117MP0002751_abnormal_autonomic_nervous0.72081355
118MP0001851_eye_inflammation0.71823896
119MP0002095_abnormal_skin_pigmentation0.71283702
120MP0001119_abnormal_female_reproductive0.71105365
121MP0008058_abnormal_DNA_repair0.70498126
122MP0002133_abnormal_respiratory_system0.69985246
123MP0005388_respiratory_system_phenotype0.69985246
124MP0000681_abnormal_thyroid_gland0.69770445
125MP0001873_stomach_inflammation0.69056101
126MP0003115_abnormal_respiratory_system0.66710531
127MP0001672_abnormal_embryogenesis/_devel0.66676347
128MP0005380_embryogenesis_phenotype0.66676347
129MP0003718_maternal_effect0.66109929
130MP0008932_abnormal_embryonic_tissue0.66053116
131MP0001666_abnormal_nutrient_absorption0.65126389
132MP0006036_abnormal_mitochondrial_physio0.64457338
133MP0008004_abnormal_stomach_pH0.64414951
134MP0000383_abnormal_hair_follicle0.63511832
135MP0003938_abnormal_ear_development0.63331443
136MP0002127_abnormal_cardiovascular_syste0.63320255
137MP0002163_abnormal_gland_morphology0.63046029
138MP0005379_endocrine/exocrine_gland_phen0.62869076
139MP0002148_abnormal_hypersensitivity_rea0.62568266
140MP0002098_abnormal_vibrissa_morphology0.62260138
141MP0002160_abnormal_reproductive_system0.59807205
142MP0001286_abnormal_eye_development0.59454891
143MP0000678_abnormal_parathyroid_gland0.59386556
144MP0001270_distended_abdomen0.59288052
145MP0002166_altered_tumor_susceptibility0.58317230
146MP0000427_abnormal_hair_cycle0.58284348
147MP0002111_abnormal_tail_morphology0.55845915
148MP0000470_abnormal_stomach_morphology0.55441168
149MP0002938_white_spotting0.55403887
150MP0001881_abnormal_mammary_gland0.55339693
151MP0005501_abnormal_skin_physiology0.54728399
152MP0005319_abnormal_enzyme/_coenzyme0.54074297
153MP0001501_abnormal_sleep_pattern0.53997906
154MP0003119_abnormal_digestive_system0.52919422
155MP0009765_abnormal_xenobiotic_induced0.51551583
156MP0004019_abnormal_vitamin_homeostasis0.51411877
157MP0002653_abnormal_ependyma_morphology0.50857092
158MP0009053_abnormal_anal_canal0.50126840
159MP0002138_abnormal_hepatobiliary_system0.49486884
160MP0001324_abnormal_eye_pigmentation0.49063733
161MP0003787_abnormal_imprinting0.48450028
162MP0002272_abnormal_nervous_system0.48332476
163MP0002092_abnormal_eye_morphology0.48323471
164MP0002752_abnormal_somatic_nervous0.46968060
165MP0000371_diluted_coat_color0.46684804
166MP0002557_abnormal_social/conspecific_i0.45570840
167MP0005389_reproductive_system_phenotype0.45156680
168MP0009745_abnormal_behavioral_response0.44611364
169MP0001186_pigmentation_phenotype0.44024792
170MP0005085_abnormal_gallbladder_physiolo0.43586414

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.29577970
2Stomach cancer (HP:0012126)5.56420663
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.23887484
4Impulsivity (HP:0100710)4.46177969
5Supernumerary spleens (HP:0009799)4.37677876
6Lip pit (HP:0100267)4.35640402
7Prostate neoplasm (HP:0100787)4.32741332
8Occipital encephalocele (HP:0002085)4.23564662
9True hermaphroditism (HP:0010459)3.99694948
10Pancreatic fibrosis (HP:0100732)3.96998085
11Infertility (HP:0000789)3.90798386
12Facial hemangioma (HP:0000329)3.90643827
13Hyperglycinemia (HP:0002154)3.69141562
14Hypoplasia of the fovea (HP:0007750)3.64405291
15Aplasia/Hypoplasia of the fovea (HP:0008060)3.64405291
16Osteomalacia (HP:0002749)3.60718908
17Tubulointerstitial nephritis (HP:0001970)3.45172853
18Rhinitis (HP:0012384)3.44581800
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34053892
20Abnormality of abdominal situs (HP:0011620)3.33382361
21Abdominal situs inversus (HP:0003363)3.33382361
22Renal tubular acidosis (HP:0001947)3.32490378
23Abnormal respiratory motile cilium physiology (HP:0012261)3.30165329
24Hyperactive renin-angiotensin system (HP:0000841)3.28814222
25Short tibia (HP:0005736)3.28124144
26Hypophosphatemic rickets (HP:0004912)3.23405828
27Aplasia/Hypoplasia of the tibia (HP:0005772)3.20093833
28Abnormal ciliary motility (HP:0012262)3.17588918
29Pancreatic cysts (HP:0001737)3.03406641
30Absent hand (HP:0004050)3.03157536
31Hypothermia (HP:0002045)3.02987250
32Renal tubular dysfunction (HP:0000124)3.01600215
33Metaphyseal dysplasia (HP:0100255)2.99517557
34Muscle stiffness (HP:0003552)2.98631216
35Hyperthyroidism (HP:0000836)2.94210698
36Periauricular skin pits (HP:0100277)2.91986291
37Preauricular pit (HP:0004467)2.91986291
38Premature ovarian failure (HP:0008209)2.91548309
39Abnormality of the fovea (HP:0000493)2.88179195
40Conjugated hyperbilirubinemia (HP:0002908)2.87591300
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86727168
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.82808314
43Absent/shortened dynein arms (HP:0200106)2.82808314
44Renal cortical cysts (HP:0000803)2.82794282
45Male pseudohermaphroditism (HP:0000037)2.77548977
46Gaze-evoked nystagmus (HP:0000640)2.77462139
47Chronic bronchitis (HP:0004469)2.72797138
48Abnormality of the labia minora (HP:0012880)2.71243494
49Abnormality of incisor morphology (HP:0011063)2.70416054
50Bile duct proliferation (HP:0001408)2.69890461
51Abnormal biliary tract physiology (HP:0012439)2.69890461
52Attenuation of retinal blood vessels (HP:0007843)2.68335233
53Aplastic anemia (HP:0001915)2.61388902
54Increased circulating renin level (HP:0000848)2.53257419
55Papillary thyroid carcinoma (HP:0002895)2.51588489
56Hyperventilation (HP:0002883)2.49666568
57Renal Fanconi syndrome (HP:0001994)2.49560298
58Tetany (HP:0001281)2.48737124
59Anterior segment dysgenesis (HP:0007700)2.46150108
60Abnormality of the tricuspid valve (HP:0001702)2.45885983
61Prolonged neonatal jaundice (HP:0006579)2.44226352
62Molar tooth sign on MRI (HP:0002419)2.44202609
63Abnormality of midbrain morphology (HP:0002418)2.44202609
64Gonadotropin excess (HP:0000837)2.41581105
65Atelectasis (HP:0100750)2.39899910
66Abnormal tarsal ossification (HP:0008369)2.39499122
67Methylmalonic acidemia (HP:0002912)2.38111111
68Nephrogenic diabetes insipidus (HP:0009806)2.37260070
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.34160864
70Hypoparathyroidism (HP:0000829)2.34090284
71Seborrheic dermatitis (HP:0001051)2.32932384
72Absent thumb (HP:0009777)2.32230019
73Split foot (HP:0001839)2.31547137
74Hypokinesia (HP:0002375)2.31205691
75Abnormality of the renal collecting system (HP:0004742)2.30510560
76Hypomagnesemia (HP:0002917)2.29361088
77Metaphyseal irregularity (HP:0003025)2.28750957
78Abnormal respiratory motile cilium morphology (HP:0005938)2.28032971
79Abnormal respiratory epithelium morphology (HP:0012253)2.28032971
80Intrahepatic cholestasis (HP:0001406)2.26979522
81Synostosis involving bones of the lower limbs (HP:0009138)2.26142336
82Synostosis involving bones of the feet (HP:0009140)2.26142336
83Postaxial foot polydactyly (HP:0001830)2.26091952
84Preaxial hand polydactyly (HP:0001177)2.24262097
85Posterior subcapsular cataract (HP:0007787)2.23170999
86Failure to thrive in infancy (HP:0001531)2.22561621
87Aplasia/Hypoplasia of the earlobes (HP:0009906)2.21766163
88Oligodactyly (hands) (HP:0001180)2.20446052
89Tarsal synostosis (HP:0008368)2.20398250
90Metabolic alkalosis (HP:0200114)2.18699139
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17569914
92Abnormal spermatogenesis (HP:0008669)2.17551731
93Azoospermia (HP:0000027)2.17540758
94Absent septum pellucidum (HP:0001331)2.15533246
95Absent speech (HP:0001344)2.15260635
96Abnormal glycosylation (HP:0012345)2.13049907
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13049907
98Abnormal protein N-linked glycosylation (HP:0012347)2.13049907
99Abnormal protein glycosylation (HP:0012346)2.13049907
100Decreased circulating renin level (HP:0003351)2.10941754
101Pulmonary artery stenosis (HP:0004415)2.10766169
102Abnormality of the preputium (HP:0100587)2.10563973
103Acne (HP:0001061)2.10296222
104Median cleft lip (HP:0000161)2.10164132
105Chorioretinal atrophy (HP:0000533)2.09547748
106Abnormal rod and cone electroretinograms (HP:0008323)2.09116767
107Abnormality of chromosome stability (HP:0003220)2.08880603
108Humeroradial synostosis (HP:0003041)2.07612606
109Synostosis involving the elbow (HP:0003938)2.07612606
110Abnormality of the fibula (HP:0002991)2.07413278
111Abnormality of the vitamin B12 metabolism (HP:0004341)2.07314666
112Abnormality of glycine metabolism (HP:0010895)2.06658286
113Abnormality of serine family amino acid metabolism (HP:0010894)2.06658286
114Aplasia/Hypoplasia of the scapulae (HP:0006713)2.06614244
115Hypoplastic scapulae (HP:0000882)2.06614244
116Overfolded helix (HP:0000396)2.06061751
117Abnormality of the prostate (HP:0008775)2.05922386
118Multiple enchondromatosis (HP:0005701)2.04744583
119Orchitis (HP:0100796)2.04620174
120Hyperammonemia (HP:0001987)2.04007513
121Severe visual impairment (HP:0001141)2.03682461
122Aplasia/Hypoplasia of the macula (HP:0008059)2.02493498
123Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01817328
124Septo-optic dysplasia (HP:0100842)2.01422867
125Chronic hepatic failure (HP:0100626)2.00934320
126Anhidrosis (HP:0000970)2.00316426
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.99823565
128Cystic liver disease (HP:0006706)1.99437246
129Reticulocytopenia (HP:0001896)1.97797792
130Vaginal fistula (HP:0004320)1.96174807
131Abnormality of chloride homeostasis (HP:0011422)1.96026732
132Hypoplasia of the uterus (HP:0000013)1.95697885
133Cleft eyelid (HP:0000625)1.95406918
134Bifid scrotum (HP:0000048)1.93458420
135Abnormal foot bone ossification (HP:0010675)1.93197632
136Dysdiadochokinesis (HP:0002075)1.93061724
137Megaloblastic anemia (HP:0001889)1.92778166
138Hyperaldosteronism (HP:0000859)1.92557481
139Abnormality of renal resorption (HP:0011038)1.92322456
140Sensory axonal neuropathy (HP:0003390)1.91934070
141Aplasia/hypoplasia of the uterus (HP:0008684)1.91757817
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91733362
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.91733362
144Type I transferrin isoform profile (HP:0003642)1.91576585
145Popliteal pterygium (HP:0009756)1.91462919
146Skin pits (HP:0100276)1.91172668
147Hyperglycinuria (HP:0003108)1.90631186
148Hypercalciuria (HP:0002150)1.90136228
149Abnormality of vitamin B metabolism (HP:0004340)1.90132279
150Proximal tubulopathy (HP:0000114)1.89665864
151Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89234433
152Malnutrition (HP:0004395)1.89113713
153Cupped ear (HP:0000378)1.88231533
154Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87875558
155Dicarboxylic aciduria (HP:0003215)1.87875558
156Femoral bowing (HP:0002980)1.86354874
157Oligohydramnios (HP:0001562)1.85504933
158Aplasia/Hypoplasia affecting the retina (HP:0008061)1.85233699
159Anencephaly (HP:0002323)1.83448457
160Chronic obstructive pulmonary disease (HP:0006510)1.83286619
161Obstructive lung disease (HP:0006536)1.83286619
162Retrobulbar optic neuritis (HP:0100654)1.83054188
163Optic neuritis (HP:0100653)1.83054188
164Abnormality of renin-angiotensin system (HP:0000847)1.82683440
165Dysmetric saccades (HP:0000641)1.82060182
166Generalized aminoaciduria (HP:0002909)1.81446148
167Palpebral edema (HP:0100540)1.81233921
168Abnormality of DNA repair (HP:0003254)1.80332099
169Bronchomalacia (HP:0002780)1.79581003
170Abnormality of macular pigmentation (HP:0008002)1.79524180
171Abnormal umbilical cord blood vessels (HP:0011403)1.78655240
172Single umbilical artery (HP:0001195)1.78655240
173Abnormality of the fetal cardiovascular system (HP:0010948)1.78655240
174Bronchiectasis (HP:0002110)1.78206799
175Chromsome breakage (HP:0040012)1.77855633
176Bone marrow hypocellularity (HP:0005528)1.77803985
177Abnormal drinking behavior (HP:0030082)1.77450243
178Polydipsia (HP:0001959)1.77450243
179Hypergonadotropic hypogonadism (HP:0000815)1.76793000
180Oligodactyly (HP:0012165)1.76573295
181Gait imbalance (HP:0002141)1.75937507
182Chorioretinal coloboma (HP:0000567)1.75821162
183Hypokalemic alkalosis (HP:0001949)1.75335177
184Absent eyebrow (HP:0002223)1.74722784
185Labial hypoplasia (HP:0000066)1.74431268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.97520317
2PRPF4B3.81368738
3MAP3K133.15248310
4SGK22.96562137
5MAP3K92.76244559
6ZAK2.74084367
7NME12.62087382
8ARAF2.58864278
9BMPR22.49314992
10NME22.38363699
11SGK2232.34985199
12SGK4942.34985199
13PDK22.30731336
14CDC72.25385547
15IRAK32.24201743
16STK38L2.23857945
17TNIK2.22195657
18BCKDK2.09548928
19CDK92.09312548
20VRK21.97249164
21AURKA1.96369348
22MAPK131.96238357
23STK161.95947801
24ERBB31.90771971
25CASK1.86676651
26CLK11.86173755
27PRKD31.83871969
28TNK21.81742535
29MAPKAPK51.76109482
30FRK1.74472571
31TRIM281.74371935
32SGK31.69918710
33IRAK11.69505398
34CSNK1A1L1.68968853
35EIF2AK21.67861438
36IRAK41.67812972
37TTK1.67606007
38CDK191.63137245
39MKNK21.55598425
40LMTK21.54807368
41MAP3K141.51253566
42NEK61.49536716
43MET1.45363251
44MUSK1.42173441
45IRAK21.35727525
46CDK71.33280740
47FER1.29641134
48STK241.28372908
49FLT31.26822977
50TEC1.23331872
51CSNK1G31.22313330
52FES1.20910834
53OXSR11.14417558
54PLK11.13619254
55PIM11.13551205
56INSRR1.12546876
57VRK11.12289506
58MAPKAPK31.12165677
59PRKCE1.11625589
60GRK11.10442696
61PAK31.10046742
62LATS11.09662595
63BRAF1.09072970
64CSNK1G11.08978786
65MATK1.07866264
66TLK11.07072467
67KIT1.06206163
68STK41.05027966
69CDK31.04600418
70PBK1.03479729
71ACVR1B1.02930708
72RPS6KB21.00747494
73JAK31.00061065
74MKNK10.98478646
75HIPK20.97926954
76NEK20.96499782
77CHEK20.95259523
78BMPR1B0.94218644
79ADRBK20.94109424
80PRKCI0.91764220
81NUAK10.87688347
82MARK10.84228644
83MAP3K110.83436913
84ATR0.82369819
85EPHA30.82138085
86AKT30.81704673
87MST40.80424123
88CSNK1G20.80272243
89CHEK10.79546123
90CAMK2A0.77946656
91MARK30.77142600
92LRRK20.75874437
93STK390.75782061
94MAP3K60.75474896
95ATM0.74529488
96TGFBR10.74178457
97CAMK2D0.74106332
98SGK10.73798165
99YES10.73613798
100MAP2K70.73204500
101AURKB0.72965097
102STK30.72692901
103CDC42BPA0.72288169
104CDK20.71754696
105TAF10.70954315
106STK380.69579887
107KDR0.69361745
108PLK20.68934941
109MAP2K30.67813627
110MELK0.67507320
111CDK80.66845428
112CAMK2B0.66440556
113PIK3CA0.66200170
114ERBB40.66162083
115NLK0.64751573
116MOS0.64322727
117SCYL20.63264790
118TESK20.63236976
119SRPK10.62164048
120TXK0.59747290
121CHUK0.58222342
122MAP2K60.57117498
123DYRK20.56625250
124EPHA40.55644420
125RPS6KA50.55279853
126BRSK20.55098258
127PINK10.54095180
128CAMK10.52534825
129TRPM70.52296842
130PRKCQ0.51497512
131ROCK10.49159886
132PIK3CG0.47651828
133CSNK1E0.47155383
134MINK10.46923077
135CSNK1A10.46764265
136RAF10.46566529
137CSNK1D0.46478514
138PRKD20.45940785
139EPHB10.45663447
140TIE10.45496752
141MAP3K10.44775469
142EPHA20.43441373
143PRKACB0.43287898
144MAPK150.41534917
145NTRK20.41151561
146SIK30.41039376
147ABL20.40615724
148PDK10.39597164
149PDPK10.39398869
150CDK10.38829838
151PKN10.36603184
152MAP3K80.36465375
153TAOK30.36286990
154RPS6KB10.35686066
155DYRK1A0.34403676
156CAMK2G0.33952629
157ABL10.33052802
158PRKG10.33038158
159DYRK30.32340210
160PRKACA0.31571153
161ROCK20.30590349
162BCR0.30327099
163PLK40.30220184
164CSNK2A20.29423735
165EIF2AK30.28897324
166LATS20.28615505
167PLK30.27987340
168CDK120.27710485

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000405.85813389
2Steroid hormone biosynthesis_Homo sapiens_hsa001404.36614703
3Sulfur metabolism_Homo sapiens_hsa009203.96742782
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.59742318
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.15471799
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00601346
7Base excision repair_Homo sapiens_hsa034102.97976574
8Mismatch repair_Homo sapiens_hsa034302.91596809
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.59601507
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.55407390
11DNA replication_Homo sapiens_hsa030302.45035819
12Chemical carcinogenesis_Homo sapiens_hsa052042.44029940
13Cell cycle_Homo sapiens_hsa041102.37908029
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.36980797
15Nucleotide excision repair_Homo sapiens_hsa034202.19563736
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.03164183
17Ribosome_Homo sapiens_hsa030101.99290760
18Non-homologous end-joining_Homo sapiens_hsa034501.98561979
19Retinol metabolism_Homo sapiens_hsa008301.96681218
20Histidine metabolism_Homo sapiens_hsa003401.93479262
21RNA transport_Homo sapiens_hsa030131.88746565
22Fatty acid elongation_Homo sapiens_hsa000621.76217130
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73408974
24ABC transporters_Homo sapiens_hsa020101.72256848
25Sulfur relay system_Homo sapiens_hsa041221.62856141
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60508121
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55486616
28Oocyte meiosis_Homo sapiens_hsa041141.54262685
29Asthma_Homo sapiens_hsa053101.52813185
30Butanoate metabolism_Homo sapiens_hsa006501.48701508
31RNA polymerase_Homo sapiens_hsa030201.46825464
32Starch and sucrose metabolism_Homo sapiens_hsa005001.46149730
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42275334
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36893896
35Collecting duct acid secretion_Homo sapiens_hsa049661.33144040
36Arginine biosynthesis_Homo sapiens_hsa002201.30950460
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29356696
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22835904
39beta-Alanine metabolism_Homo sapiens_hsa004101.19903997
40Nicotine addiction_Homo sapiens_hsa050331.18885658
41Taste transduction_Homo sapiens_hsa047421.17488810
42Tyrosine metabolism_Homo sapiens_hsa003501.13545642
43Rheumatoid arthritis_Homo sapiens_hsa053231.12823179
44Propanoate metabolism_Homo sapiens_hsa006401.10352051
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09185048
46p53 signaling pathway_Homo sapiens_hsa041151.07088531
47Fanconi anemia pathway_Homo sapiens_hsa034601.05443795
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04880225
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03124957
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.02004071
51Arachidonic acid metabolism_Homo sapiens_hsa005901.00543933
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99068659
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.96049642
54Linoleic acid metabolism_Homo sapiens_hsa005910.93738595
55Ovarian steroidogenesis_Homo sapiens_hsa049130.92777205
56Pyrimidine metabolism_Homo sapiens_hsa002400.91589019
57Nitrogen metabolism_Homo sapiens_hsa009100.89616251
58Vibrio cholerae infection_Homo sapiens_hsa051100.86084632
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85612947
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.83419307
61Notch signaling pathway_Homo sapiens_hsa043300.79948304
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79928883
63Spliceosome_Homo sapiens_hsa030400.79768629
64Phenylalanine metabolism_Homo sapiens_hsa003600.79363566
65Homologous recombination_Homo sapiens_hsa034400.79070969
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75337378
67Huntingtons disease_Homo sapiens_hsa050160.74885097
68Selenocompound metabolism_Homo sapiens_hsa004500.74646263
69One carbon pool by folate_Homo sapiens_hsa006700.73806668
70Platelet activation_Homo sapiens_hsa046110.73648464
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73324451
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72851872
73Long-term depression_Homo sapiens_hsa047300.72435452
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68332215
75Phototransduction_Homo sapiens_hsa047440.66227544
76Gastric acid secretion_Homo sapiens_hsa049710.65884293
77Salivary secretion_Homo sapiens_hsa049700.65213791
78Vitamin digestion and absorption_Homo sapiens_hsa049770.64720833
79Regulation of autophagy_Homo sapiens_hsa041400.64702377
80Oxidative phosphorylation_Homo sapiens_hsa001900.64700590
81mRNA surveillance pathway_Homo sapiens_hsa030150.64475567
82Basal transcription factors_Homo sapiens_hsa030220.61518811
83Olfactory transduction_Homo sapiens_hsa047400.60960801
84Glutathione metabolism_Homo sapiens_hsa004800.60748127
85Arginine and proline metabolism_Homo sapiens_hsa003300.60647137
86Serotonergic synapse_Homo sapiens_hsa047260.60511616
87Inositol phosphate metabolism_Homo sapiens_hsa005620.60090129
88Axon guidance_Homo sapiens_hsa043600.58456894
89Dorso-ventral axis formation_Homo sapiens_hsa043200.58310048
90Adherens junction_Homo sapiens_hsa045200.57780920
91Circadian rhythm_Homo sapiens_hsa047100.57760555
92Graft-versus-host disease_Homo sapiens_hsa053320.56846718
93TGF-beta signaling pathway_Homo sapiens_hsa043500.56053047
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.55569044
95Prostate cancer_Homo sapiens_hsa052150.53790678
96Peroxisome_Homo sapiens_hsa041460.53148065
97Cocaine addiction_Homo sapiens_hsa050300.52729478
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52173847
99Pentose phosphate pathway_Homo sapiens_hsa000300.51727719
100Biosynthesis of amino acids_Homo sapiens_hsa012300.51619777
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50284002
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.50201167
103Tight junction_Homo sapiens_hsa045300.48602593
104African trypanosomiasis_Homo sapiens_hsa051430.47960781
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46824769
106Protein export_Homo sapiens_hsa030600.46164249
107Ether lipid metabolism_Homo sapiens_hsa005650.46146281
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45344691
109N-Glycan biosynthesis_Homo sapiens_hsa005100.44928684
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42250632
111Folate biosynthesis_Homo sapiens_hsa007900.41408723
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41154380
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.40886172
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40026115
115Vitamin B6 metabolism_Homo sapiens_hsa007500.39719733
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39157131
117Amphetamine addiction_Homo sapiens_hsa050310.37156896
118Fat digestion and absorption_Homo sapiens_hsa049750.36502124
119Sphingolipid metabolism_Homo sapiens_hsa006000.36041271
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35385692
121Fatty acid degradation_Homo sapiens_hsa000710.34798014
122ErbB signaling pathway_Homo sapiens_hsa040120.34243728
123Carbon metabolism_Homo sapiens_hsa012000.33979904
124RNA degradation_Homo sapiens_hsa030180.32925870
125Morphine addiction_Homo sapiens_hsa050320.32134450
126Allograft rejection_Homo sapiens_hsa053300.32057593
127Herpes simplex infection_Homo sapiens_hsa051680.32030933
128Hepatitis C_Homo sapiens_hsa051600.31952380
129Synaptic vesicle cycle_Homo sapiens_hsa047210.30140344
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29602229
131Cholinergic synapse_Homo sapiens_hsa047250.29490174
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28952766
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28906816
134Renin-angiotensin system_Homo sapiens_hsa046140.28222606
135Mineral absorption_Homo sapiens_hsa049780.28111033
136Metabolic pathways_Homo sapiens_hsa011000.27460299
137Gap junction_Homo sapiens_hsa045400.27298997
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26647589
139Alzheimers disease_Homo sapiens_hsa050100.25419510
140Purine metabolism_Homo sapiens_hsa002300.25148822
141Endometrial cancer_Homo sapiens_hsa052130.24979944
142Melanoma_Homo sapiens_hsa052180.24828686
143Calcium signaling pathway_Homo sapiens_hsa040200.23989451
144Phagosome_Homo sapiens_hsa041450.23188700
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23127380
146Autoimmune thyroid disease_Homo sapiens_hsa053200.22621193
147Galactose metabolism_Homo sapiens_hsa000520.22494589
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22232886
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.20943286
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20292363
151Hematopoietic cell lineage_Homo sapiens_hsa046400.17396182
152Tryptophan metabolism_Homo sapiens_hsa003800.16845177
153Caffeine metabolism_Homo sapiens_hsa002320.16172122
154Hippo signaling pathway_Homo sapiens_hsa043900.15506099
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14596206
156Glutamatergic synapse_Homo sapiens_hsa047240.13622499

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