

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.18111744 |
| 2 | NIK/NF-kappaB signaling (GO:0038061) | 5.79417076 |
| 3 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.94392227 |
| 4 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.94392227 |
| 5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.78596575 |
| 6 | B cell receptor signaling pathway (GO:0050853) | 4.52531169 |
| 7 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.42307908 |
| 8 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 4.30693237 |
| 9 | cellular response to zinc ion (GO:0071294) | 4.28389266 |
| 10 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.16673341 |
| 11 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.11992245 |
| 12 | natural killer cell mediated cytotoxicity (GO:0042267) | 4.05838215 |
| 13 | natural killer cell mediated immunity (GO:0002228) | 4.05838215 |
| 14 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.99984415 |
| 15 | positive regulation of B cell differentiation (GO:0045579) | 3.96894368 |
| 16 | positive regulation of interferon-alpha production (GO:0032727) | 3.91529105 |
| 17 | regulation of B cell differentiation (GO:0045577) | 3.85382751 |
| 18 | positive regulation of antigen processing and presentation (GO:0002579) | 3.77338661 |
| 19 | immunoglobulin mediated immune response (GO:0016064) | 3.73533253 |
| 20 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.73342500 |
| 21 | regulation of interferon-alpha production (GO:0032647) | 3.70192315 |
| 22 | mature B cell differentiation (GO:0002335) | 3.63308179 |
| 23 | pinocytosis (GO:0006907) | 3.57101485 |
| 24 | negative thymic T cell selection (GO:0045060) | 3.50713011 |
| 25 | neutrophil activation involved in immune response (GO:0002283) | 3.46081292 |
| 26 | response to muramyl dipeptide (GO:0032495) | 3.44994472 |
| 27 | germinal center formation (GO:0002467) | 3.42522902 |
| 28 | myeloid dendritic cell differentiation (GO:0043011) | 3.38498498 |
| 29 | positive regulation of interleukin-12 production (GO:0032735) | 3.38088240 |
| 30 | membrane raft organization (GO:0031579) | 3.36469601 |
| 31 | neutrophil activation (GO:0042119) | 3.35187343 |
| 32 | N-acetylneuraminate metabolic process (GO:0006054) | 3.34606936 |
| 33 | myeloid dendritic cell activation (GO:0001773) | 3.34083725 |
| 34 | B cell mediated immunity (GO:0019724) | 3.33767162 |
| 35 | regulation of antigen processing and presentation (GO:0002577) | 3.33236895 |
| 36 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.32812951 |
| 37 | regulation of gamma-delta T cell activation (GO:0046643) | 3.29119427 |
| 38 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.29062560 |
| 39 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.28858693 |
| 40 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.23407829 |
| 41 | negative regulation of B cell proliferation (GO:0030889) | 3.20049795 |
| 42 | negative T cell selection (GO:0043383) | 3.19349942 |
| 43 | B cell proliferation (GO:0042100) | 3.17584850 |
| 44 | regulation of RIG-I signaling pathway (GO:0039535) | 3.15132872 |
| 45 | positive thymic T cell selection (GO:0045059) | 3.13140731 |
| 46 | granulocyte activation (GO:0036230) | 3.12173427 |
| 47 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.07093859 |
| 48 | response to type I interferon (GO:0034340) | 3.05420166 |
| 49 | cellular response to type I interferon (GO:0071357) | 3.01696891 |
| 50 | type I interferon signaling pathway (GO:0060337) | 3.01696891 |
| 51 | regulation of B cell proliferation (GO:0030888) | 3.01687778 |
| 52 | defense response to protozoan (GO:0042832) | 3.00588613 |
| 53 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.98648162 |
| 54 | positive regulation of interferon-beta production (GO:0032728) | 2.96823366 |
| 55 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.96785949 |
| 56 | regulation of necroptotic process (GO:0060544) | 2.95979112 |
| 57 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.95335942 |
| 58 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.95335942 |
| 59 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.95335942 |
| 60 | modulation by symbiont of host immune response (GO:0052553) | 2.95335942 |
| 61 | positive regulation by symbiont of host defense response (GO:0052509) | 2.95335942 |
| 62 | modulation by symbiont of host defense response (GO:0052031) | 2.95335942 |
| 63 | regulation of interleukin-12 production (GO:0032655) | 2.94148112 |
| 64 | cellular extravasation (GO:0045123) | 2.93519396 |
| 65 | positive regulation of interleukin-2 production (GO:0032743) | 2.92116528 |
| 66 | B cell homeostasis (GO:0001782) | 2.91745934 |
| 67 | blood vessel maturation (GO:0001955) | 2.90723449 |
| 68 | dendritic cell differentiation (GO:0097028) | 2.90352568 |
| 69 | mature B cell differentiation involved in immune response (GO:0002313) | 2.90274812 |
| 70 | protein localization to endosome (GO:0036010) | 2.89898678 |
| 71 | positive regulation of protein homooligomerization (GO:0032464) | 2.86631801 |
| 72 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.86561841 |
| 73 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.86045046 |
| 74 | hepatocyte apoptotic process (GO:0097284) | 2.85153378 |
| 75 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.85044816 |
| 76 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.84813771 |
| 77 | stress fiber assembly (GO:0043149) | 2.84237441 |
| 78 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.83273323 |
| 79 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.83153613 |
| 80 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.81944034 |
| 81 | lymphocyte mediated immunity (GO:0002449) | 2.81562320 |
| 82 | regulation of B cell apoptotic process (GO:0002902) | 2.81254432 |
| 83 | response to peptidoglycan (GO:0032494) | 2.81132066 |
| 84 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.79515045 |
| 85 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.79242909 |
| 86 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.79081970 |
| 87 | leukocyte mediated cytotoxicity (GO:0001909) | 2.79068323 |
| 88 | macrophage activation involved in immune response (GO:0002281) | 2.78887168 |
| 89 | thymic T cell selection (GO:0045061) | 2.77808454 |
| 90 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.76274033 |
| 91 | positive regulation of protein oligomerization (GO:0032461) | 2.75406922 |
| 92 | histamine secretion (GO:0001821) | 2.73265884 |
| 93 | positive regulation of macrophage cytokine production (GO:0060907) | 2.71550272 |
| 94 | positive regulation of B cell proliferation (GO:0030890) | 2.71059633 |
| 95 | regulation of T cell tolerance induction (GO:0002664) | 2.69589307 |
| 96 | response to protozoan (GO:0001562) | 2.68988579 |
| 97 | detection of other organism (GO:0098543) | 2.68580602 |
| 98 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.68061120 |
| 99 | negative regulation of interleukin-12 production (GO:0032695) | 2.65988004 |
| 100 | response to host defenses (GO:0052200) | 2.65909561 |
| 101 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.65909561 |
| 102 | response to host (GO:0075136) | 2.65909561 |
| 103 | positive regulation of B cell activation (GO:0050871) | 2.65567050 |
| 104 | positive regulation of type 2 immune response (GO:0002830) | 2.64975649 |
| 105 | T cell migration (GO:0072678) | 2.62731431 |
| 106 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.60953301 |
| 107 | regulation of interferon-beta production (GO:0032648) | 2.60456805 |
| 108 | regulation of B cell activation (GO:0050864) | 2.60178459 |
| 109 | cellular response to interferon-beta (GO:0035458) | 2.59834200 |
| 110 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.57986425 |
| 111 | dendritic cell chemotaxis (GO:0002407) | 2.57760624 |
| 112 | detection of bacterium (GO:0016045) | 2.56602576 |
| 113 | dendritic cell migration (GO:0036336) | 2.54808190 |
| 114 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 2.54758060 |
| 115 | cellular response to exogenous dsRNA (GO:0071360) | 2.54105905 |
| 116 | Rap protein signal transduction (GO:0032486) | 2.53489016 |
| 117 | T-helper 1 type immune response (GO:0042088) | 2.53372348 |
| 118 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.53247954 |
| 119 | T cell lineage commitment (GO:0002360) | 2.52891362 |
| 120 | positive regulation of neutrophil chemotaxis (GO:0090023) | 2.52695774 |
| 121 | positive regulation of neutrophil migration (GO:1902624) | 2.52695774 |
| 122 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.52362423 |
| 123 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 2.52289182 |
| 124 | lymphocyte homeostasis (GO:0002260) | 2.51487813 |
| 125 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.50966865 |
| 126 | amino sugar catabolic process (GO:0046348) | 2.49736291 |
| 127 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.49126681 |
| 128 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.46711360 |
| 129 | nuclear pore complex assembly (GO:0051292) | 2.46409463 |
| 130 | wound healing, spreading of epidermal cells (GO:0035313) | 2.44561021 |
| 131 | endothelium development (GO:0003158) | 2.42383158 |
| 132 | response to host immune response (GO:0052572) | 2.42308275 |
| 133 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.42308275 |
| 134 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.42304451 |
| 135 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.41083063 |
| 136 | adhesion of symbiont to host cell (GO:0044650) | 2.40851826 |
| 137 | virion attachment to host cell (GO:0019062) | 2.40851826 |
| 138 | angiogenesis involved in wound healing (GO:0060055) | 2.37595935 |
| 139 | regulation of germinal center formation (GO:0002634) | 2.34885872 |
| 140 | cellular response to interferon-gamma (GO:0071346) | 2.34188760 |
| 141 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.32866669 |
| 142 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.31600569 |
| 143 | intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631) | 2.30641687 |
| 144 | regulation of macrophage cytokine production (GO:0010935) | 2.28173642 |
| 145 | microglial cell activation (GO:0001774) | 2.28138645 |
| 146 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.27985886 |
| 147 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.26049709 |
| 148 | detection of external biotic stimulus (GO:0098581) | 2.25386872 |
| 149 | wound healing, spreading of cells (GO:0044319) | 2.24547502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.21853561 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.01281717 |
| 3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.54746591 |
| 4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.42976667 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.28273372 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.20434466 |
| 7 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.33437159 |
| 8 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.18944657 |
| 9 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.09147355 |
| 10 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.04231785 |
| 11 | MYC_22102868_ChIP-Seq_BL_Human | 3.03460642 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.97058036 |
| 13 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.86756565 |
| 14 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.66172942 |
| 15 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.50331846 |
| 16 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.47533129 |
| 17 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.41799143 |
| 18 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.39437641 |
| 19 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.31670294 |
| 20 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.19261071 |
| 21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.18819682 |
| 22 | MAF_26560356_Chip-Seq_TH1_Human | 2.18462934 |
| 23 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.18215933 |
| 24 | MYB_26560356_Chip-Seq_TH2_Human | 2.14695077 |
| 25 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.09524829 |
| 26 | MYB_26560356_Chip-Seq_TH1_Human | 2.07304397 |
| 27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.96459666 |
| 28 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.93336312 |
| 29 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.92101820 |
| 30 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.87033779 |
| 31 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.84010143 |
| 32 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.83706166 |
| 33 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.82547927 |
| 34 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.81009875 |
| 35 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.79966819 |
| 36 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.79460601 |
| 37 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.78575829 |
| 38 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.74561138 |
| 39 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.67806248 |
| 40 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.67494489 |
| 41 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.66601473 |
| 42 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.63638337 |
| 43 | UTX_26944678_Chip-Seq_JUKART_Human | 1.61989568 |
| 44 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.58571632 |
| 45 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.58384314 |
| 46 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.56112973 |
| 47 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.50469508 |
| 48 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.48914257 |
| 49 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.47432280 |
| 50 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.43691033 |
| 51 | GATA1_22025678_ChIP-Seq_K562_Human | 1.41969352 |
| 52 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37553821 |
| 53 | * SPI1_23127762_ChIP-Seq_K562_Human | 1.36450374 |
| 54 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.34398731 |
| 55 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.34300656 |
| 56 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.32654435 |
| 57 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32556643 |
| 58 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.32338142 |
| 59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31648407 |
| 60 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31470687 |
| 61 | MAF_26560356_Chip-Seq_TH2_Human | 1.29018883 |
| 62 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.24880984 |
| 63 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.23583467 |
| 64 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.23560628 |
| 65 | * GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.21683678 |
| 66 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.18655698 |
| 67 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.18056133 |
| 68 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.17561185 |
| 69 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.17522144 |
| 70 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.16175170 |
| 71 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15685971 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.14517010 |
| 73 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.12270022 |
| 74 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.08990597 |
| 75 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.08046855 |
| 76 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.07630210 |
| 77 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.05022621 |
| 78 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.04394764 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.02979897 |
| 80 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.02584109 |
| 81 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.02307344 |
| 82 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.01855747 |
| 83 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.00205869 |
| 84 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.99704733 |
| 85 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.99670508 |
| 86 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.99606708 |
| 87 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99567651 |
| 88 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.98591277 |
| 89 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.96733462 |
| 90 | * CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.96100837 |
| 91 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.95820935 |
| 92 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.95765116 |
| 93 | GATA3_26560356_Chip-Seq_TH2_Human | 0.94509089 |
| 94 | CJUN_26792858_Chip-Seq_BT549_Human | 0.93682352 |
| 95 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93221214 |
| 96 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.92805796 |
| 97 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.92386583 |
| 98 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.91776575 |
| 99 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89940837 |
| 100 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89411226 |
| 101 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89084332 |
| 102 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.88256712 |
| 103 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.87992142 |
| 104 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.87472034 |
| 105 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.86978447 |
| 106 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.85410399 |
| 107 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84928286 |
| 108 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.84857309 |
| 109 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.84102820 |
| 110 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.81926863 |
| 111 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.81891345 |
| 112 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.81891345 |
| 113 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.81601210 |
| 114 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.81233502 |
| 115 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.78627040 |
| 116 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.78081290 |
| 117 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.77732824 |
| 118 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.77524608 |
| 119 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.77163167 |
| 120 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.76664778 |
| 121 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.76571908 |
| 122 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.75925387 |
| 123 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.74617117 |
| 124 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.73579423 |
| 125 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.72910820 |
| 126 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.71740274 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.87819985 |
| 2 | MP0000685_abnormal_immune_system | 3.61186079 |
| 3 | MP0005387_immune_system_phenotype | 3.46552051 |
| 4 | MP0001790_abnormal_immune_system | 3.46552051 |
| 5 | * MP0001800_abnormal_humoral_immune | 3.34845793 |
| 6 | * MP0002452_abnormal_antigen_presenting | 2.88602602 |
| 7 | * MP0005000_abnormal_immune_tolerance | 2.70073201 |
| 8 | MP0003303_peritoneal_inflammation | 2.61210818 |
| 9 | MP0002148_abnormal_hypersensitivity_rea | 2.61053430 |
| 10 | MP0002166_altered_tumor_susceptibility | 2.57256547 |
| 11 | * MP0002723_abnormal_immune_serum | 2.51275681 |
| 12 | MP0005671_abnormal_response_to | 2.50132503 |
| 13 | * MP0002420_abnormal_adaptive_immunity | 2.39739916 |
| 14 | * MP0001819_abnormal_immune_cell | 2.38051224 |
| 15 | MP0009785_altered_susceptibility_to | 2.36387809 |
| 16 | MP0003436_decreased_susceptibility_to | 2.35850938 |
| 17 | MP0004510_myositis | 2.35844504 |
| 18 | MP0002254_reproductive_system_inflammat | 2.20179945 |
| 19 | MP0002419_abnormal_innate_immunity | 2.19937300 |
| 20 | MP0005025_abnormal_response_to | 2.16047738 |
| 21 | * MP0002398_abnormal_bone_marrow | 2.15307866 |
| 22 | MP0002006_tumorigenesis | 2.12353310 |
| 23 | MP0005275_abnormal_skin_tensile | 2.05943029 |
| 24 | MP0002138_abnormal_hepatobiliary_system | 2.05372376 |
| 25 | MP0010352_gastrointestinal_tract_polyps | 2.04551595 |
| 26 | MP0002396_abnormal_hematopoietic_system | 2.03908305 |
| 27 | * MP0000716_abnormal_immune_system | 2.00902182 |
| 28 | MP0003950_abnormal_plasma_membrane | 1.93837260 |
| 29 | MP0008057_abnormal_DNA_replication | 1.87821626 |
| 30 | MP0000689_abnormal_spleen_morphology | 1.84552810 |
| 31 | MP0000569_abnormal_digit_pigmentation | 1.84345393 |
| 32 | MP0001853_heart_inflammation | 1.82603585 |
| 33 | MP0001873_stomach_inflammation | 1.81140074 |
| 34 | MP0002405_respiratory_system_inflammati | 1.75365686 |
| 35 | MP0003300_gastrointestinal_ulcer | 1.72617818 |
| 36 | MP0003763_abnormal_thymus_physiology | 1.70155706 |
| 37 | MP0001348_abnormal_lacrimal_gland | 1.69320721 |
| 38 | * MP0002429_abnormal_blood_cell | 1.68829494 |
| 39 | MP0005310_abnormal_salivary_gland | 1.67999431 |
| 40 | MP0002722_abnormal_immune_system | 1.66806072 |
| 41 | MP0004947_skin_inflammation | 1.66020169 |
| 42 | MP0005257_abnormal_intraocular_pressure | 1.64675985 |
| 43 | MP0004808_abnormal_hematopoietic_stem | 1.59733895 |
| 44 | MP0010155_abnormal_intestine_physiology | 1.59129050 |
| 45 | MP0005076_abnormal_cell_differentiation | 1.52432116 |
| 46 | MP0001845_abnormal_inflammatory_respons | 1.48772940 |
| 47 | MP0002009_preneoplasia | 1.47745034 |
| 48 | MP0010368_abnormal_lymphatic_system | 1.44963607 |
| 49 | MP0003191_abnormal_cellular_cholesterol | 1.39446625 |
| 50 | MP0003091_abnormal_cell_migration | 1.34894850 |
| 51 | MP0009278_abnormal_bone_marrow | 1.33574369 |
| 52 | MP0005464_abnormal_platelet_physiology | 1.33517050 |
| 53 | MP0003566_abnormal_cell_adhesion | 1.33407299 |
| 54 | MP0005503_abnormal_tendon_morphology | 1.33324558 |
| 55 | MP0006082_CNS_inflammation | 1.33199062 |
| 56 | MP0004272_abnormal_basement_membrane | 1.31612564 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.30165861 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.30165861 |
| 59 | MP0009333_abnormal_splenocyte_physiolog | 1.28893231 |
| 60 | MP0010307_abnormal_tumor_latency | 1.27641700 |
| 61 | MP0000703_abnormal_thymus_morphology | 1.23330376 |
| 62 | MP0003448_altered_tumor_morphology | 1.23181644 |
| 63 | MP0000343_altered_response_to | 1.21345258 |
| 64 | MP0001879_abnormal_lymphatic_vessel | 1.15741900 |
| 65 | MP0002877_abnormal_melanocyte_morpholog | 1.10751108 |
| 66 | MP0003077_abnormal_cell_cycle | 1.09578976 |
| 67 | MP0001533_abnormal_skeleton_physiology | 1.07579121 |
| 68 | MP0005174_abnormal_tail_pigmentation | 1.07200108 |
| 69 | MP0001542_abnormal_bone_strength | 1.07057382 |
| 70 | MP0002163_abnormal_gland_morphology | 1.06827502 |
| 71 | MP0010094_abnormal_chromosome_stability | 1.06163596 |
| 72 | MP0008469_abnormal_protein_level | 1.01708690 |
| 73 | MP0002933_joint_inflammation | 1.01356059 |
| 74 | MP0003183_abnormal_peptide_metabolism | 1.00663643 |
| 75 | MP0003724_increased_susceptibility_to | 1.00191442 |
| 76 | MP0000767_abnormal_smooth_muscle | 0.98765932 |
| 77 | MP0000858_altered_metastatic_potential | 0.96615637 |
| 78 | MP0000490_abnormal_crypts_of | 0.96492698 |
| 79 | MP0003453_abnormal_keratinocyte_physiol | 0.96088966 |
| 80 | MP0002019_abnormal_tumor_incidence | 0.95273331 |
| 81 | MP0005164_abnormal_response_to | 0.95044072 |
| 82 | MP0003172_abnormal_lysosome_physiology | 0.94074399 |
| 83 | MP0003828_pulmonary_edema | 0.93277567 |
| 84 | MP0000465_gastrointestinal_hemorrhage | 0.93121820 |
| 85 | MP0003705_abnormal_hypodermis_morpholog | 0.91693340 |
| 86 | MP0003941_abnormal_skin_development | 0.90730195 |
| 87 | MP0002277_abnormal_respiratory_mucosa | 0.89973331 |
| 88 | MP0003693_abnormal_embryo_hatching | 0.89070411 |
| 89 | MP0009840_abnormal_foam_cell | 0.89052552 |
| 90 | MP0008007_abnormal_cellular_replicative | 0.88734885 |
| 91 | MP0005023_abnormal_wound_healing | 0.84469108 |
| 92 | MP0005058_abnormal_lysosome_morphology | 0.84004419 |
| 93 | MP0000350_abnormal_cell_proliferation | 0.83493254 |
| 94 | MP0006054_spinal_hemorrhage | 0.83089197 |
| 95 | MP0000371_diluted_coat_color | 0.82739882 |
| 96 | MP0003111_abnormal_nucleus_morphology | 0.81097167 |
| 97 | MP0009764_decreased_sensitivity_to | 0.80641184 |
| 98 | MP0008004_abnormal_stomach_pH | 0.80181530 |
| 99 | MP0008260_abnormal_autophagy | 0.80074560 |
| 100 | MP0005165_increased_susceptibility_to | 0.78993056 |
| 101 | MP0002998_abnormal_bone_remodeling | 0.78386447 |
| 102 | MP0005390_skeleton_phenotype | 0.77802707 |
| 103 | MP0000249_abnormal_blood_vessel | 0.77276988 |
| 104 | MP0005623_abnormal_meninges_morphology | 0.75903770 |
| 105 | MP0002060_abnormal_skin_morphology | 0.75291619 |
| 106 | MP0001851_eye_inflammation | 0.73994170 |
| 107 | MP0010234_abnormal_vibrissa_follicle | 0.73919613 |
| 108 | MP0001346_abnormal_lacrimal_gland | 0.72402209 |
| 109 | MP0002136_abnormal_kidney_physiology | 0.72007563 |
| 110 | MP0003866_abnormal_defecation | 0.71911220 |
| 111 | MP0000015_abnormal_ear_pigmentation | 0.71360224 |
| 112 | MP0005621_abnormal_cell_physiology | 0.70876915 |
| 113 | MP0001915_intracranial_hemorrhage | 0.70776385 |
| 114 | MP0000733_abnormal_muscle_development | 0.66949571 |
| 115 | MP0001958_emphysema | 0.66884513 |
| 116 | MP0003045_fibrosis | 0.65556393 |
| 117 | MP0003279_aneurysm | 0.64286496 |
| 118 | MP0008438_abnormal_cutaneous_collagen | 0.61452574 |
| 119 | * MP0000313_abnormal_cell_death | 0.61252956 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Agammaglobulinemia (HP:0004432) | 5.66171899 |
| 2 | Gastrointestinal stroma tumor (HP:0100723) | 4.80331549 |
| 3 | Colitis (HP:0002583) | 4.69657483 |
| 4 | Recurrent abscess formation (HP:0002722) | 4.64516664 |
| 5 | Recurrent viral infections (HP:0004429) | 4.52830724 |
| 6 | Recurrent bacterial skin infections (HP:0005406) | 4.47476462 |
| 7 | Cellulitis (HP:0100658) | 4.41313578 |
| 8 | Eczematoid dermatitis (HP:0000976) | 4.29388780 |
| 9 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.20826505 |
| 10 | Recurrent bronchitis (HP:0002837) | 4.18022906 |
| 11 | Recurrent fungal infections (HP:0002841) | 3.98691926 |
| 12 | Inflammation of the large intestine (HP:0002037) | 3.87427044 |
| 13 | Vasculitis (HP:0002633) | 3.86257736 |
| 14 | Chronic otitis media (HP:0000389) | 3.78590697 |
| 15 | Gastrointestinal inflammation (HP:0004386) | 3.70288393 |
| 16 | Mediastinal lymphadenopathy (HP:0100721) | 3.68073654 |
| 17 | Emphysema (HP:0002097) | 3.62729387 |
| 18 | Protrusio acetabuli (HP:0003179) | 3.58704852 |
| 19 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.58516772 |
| 20 | Autoimmune thrombocytopenia (HP:0001973) | 3.53337316 |
| 21 | Lymphopenia (HP:0001888) | 3.48730517 |
| 22 | Aortic aneurysm (HP:0004942) | 3.40117455 |
| 23 | IgA deficiency (HP:0002720) | 3.35411255 |
| 24 | Meningitis (HP:0001287) | 3.33935901 |
| 25 | Thrombocytosis (HP:0001894) | 3.32652604 |
| 26 | Hematochezia (HP:0002573) | 3.31082014 |
| 27 | IgM deficiency (HP:0002850) | 3.26805396 |
| 28 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.24563973 |
| 29 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.24563973 |
| 30 | Abnormality of glycolipid metabolism (HP:0010969) | 3.24563973 |
| 31 | Myositis (HP:0100614) | 3.24297050 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.23470800 |
| 33 | Recurrent cutaneous fungal infections (HP:0011370) | 3.23470800 |
| 34 | Panhypogammaglobulinemia (HP:0003139) | 3.23152467 |
| 35 | Recurrent skin infections (HP:0001581) | 3.21198747 |
| 36 | Recurrent sinusitis (HP:0011108) | 3.18189104 |
| 37 | Osteomyelitis (HP:0002754) | 3.16651350 |
| 38 | Recurrent lower respiratory tract infections (HP:0002783) | 3.13699029 |
| 39 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.12798171 |
| 40 | Premature rupture of membranes (HP:0001788) | 3.12493592 |
| 41 | Verrucae (HP:0200043) | 3.11105275 |
| 42 | Papilloma (HP:0012740) | 3.11105275 |
| 43 | Vascular tortuosity (HP:0004948) | 3.08367501 |
| 44 | Recurrent pneumonia (HP:0006532) | 3.03570165 |
| 45 | Arterial tortuosity (HP:0005116) | 2.98504982 |
| 46 | Spondylolisthesis (HP:0003302) | 2.94841438 |
| 47 | Chronic sinusitis (HP:0011109) | 2.90619405 |
| 48 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.81633744 |
| 49 | Retrobulbar optic neuritis (HP:0100654) | 2.80447375 |
| 50 | Optic neuritis (HP:0100653) | 2.80447375 |
| 51 | Abnormality of T cell physiology (HP:0011840) | 2.79455781 |
| 52 | Pulmonary infiltrates (HP:0002113) | 2.76913095 |
| 53 | Orchitis (HP:0100796) | 2.74488028 |
| 54 | Aortic dissection (HP:0002647) | 2.74442910 |
| 55 | Abnormality of the fingertips (HP:0001211) | 2.72290935 |
| 56 | Eosinophilia (HP:0001880) | 2.67726337 |
| 57 | Osteolytic defects of the hand bones (HP:0009699) | 2.63646176 |
| 58 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.63646176 |
| 59 | Viral hepatitis (HP:0006562) | 2.60083271 |
| 60 | Interstitial pulmonary disease (HP:0006530) | 2.59103694 |
| 61 | Periodontitis (HP:0000704) | 2.58441371 |
| 62 | Restrictive lung disease (HP:0002091) | 2.56893207 |
| 63 | Arterial thrombosis (HP:0004420) | 2.56314472 |
| 64 | Abnormality of macrophages (HP:0004311) | 2.53212147 |
| 65 | Pustule (HP:0200039) | 2.52551230 |
| 66 | Fatigue (HP:0012378) | 2.52266129 |
| 67 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.51194700 |
| 68 | Leukopenia (HP:0001882) | 2.49989300 |
| 69 | Conjunctival telangiectasia (HP:0000524) | 2.47762062 |
| 70 | Nasal polyposis (HP:0100582) | 2.45954854 |
| 71 | Spontaneous hematomas (HP:0007420) | 2.44521752 |
| 72 | Dilatation of the ascending aorta (HP:0005111) | 2.43851442 |
| 73 | Abnormality of the prostate (HP:0008775) | 2.42451401 |
| 74 | IgG deficiency (HP:0004315) | 2.41803670 |
| 75 | Abnormality of T cells (HP:0002843) | 2.40911400 |
| 76 | Increased IgE level (HP:0003212) | 2.40024386 |
| 77 | Granulocytopenia (HP:0001913) | 2.39897611 |
| 78 | Abnormality of B cell number (HP:0010975) | 2.39282888 |
| 79 | B lymphocytopenia (HP:0010976) | 2.39282888 |
| 80 | Vacuolated lymphocytes (HP:0001922) | 2.34327511 |
| 81 | Abnormality of the nasal mucosa (HP:0000433) | 2.33951549 |
| 82 | Dysostosis multiplex (HP:0000943) | 2.31590551 |
| 83 | Increased IgM level (HP:0003496) | 2.31389605 |
| 84 | Chronic diarrhea (HP:0002028) | 2.30688196 |
| 85 | Leukocytosis (HP:0001974) | 2.30194109 |
| 86 | Gingivitis (HP:0000230) | 2.29741665 |
| 87 | Albinism (HP:0001022) | 2.27926257 |
| 88 | Myocardial infarction (HP:0001658) | 2.26118059 |
| 89 | Cervical subluxation (HP:0003308) | 2.25227060 |
| 90 | Skin ulcer (HP:0200042) | 2.24614510 |
| 91 | Mucosal telangiectasiae (HP:0100579) | 2.23714249 |
| 92 | Persistence of primary teeth (HP:0006335) | 2.23078929 |
| 93 | Xerostomia (HP:0000217) | 2.22859168 |
| 94 | Lymphoma (HP:0002665) | 2.18421099 |
| 95 | Chronic obstructive pulmonary disease (HP:0006510) | 2.17720558 |
| 96 | Obstructive lung disease (HP:0006536) | 2.17720558 |
| 97 | Thoracolumbar scoliosis (HP:0002944) | 2.17226346 |
| 98 | Encephalitis (HP:0002383) | 2.17212816 |
| 99 | Abnormality of T cell number (HP:0011839) | 2.16851664 |
| 100 | Thyroiditis (HP:0100646) | 2.16759304 |
| 101 | Bronchitis (HP:0012387) | 2.14913357 |
| 102 | Natal tooth (HP:0000695) | 2.14563189 |
| 103 | Sepsis (HP:0100806) | 2.11992711 |
| 104 | Hypergammaglobulinemia (HP:0010702) | 2.11541992 |
| 105 | Vertebral compression fractures (HP:0002953) | 2.05829634 |
| 106 | Chest pain (HP:0100749) | 2.03285858 |
| 107 | Increased cerebral lipofuscin (HP:0011813) | 2.01863711 |
| 108 | Arthralgia (HP:0002829) | 1.97640989 |
| 109 | Amaurosis fugax (HP:0100576) | 1.96447342 |
| 110 | Abnormality of eosinophils (HP:0001879) | 1.95572466 |
| 111 | Ankle contracture (HP:0006466) | 1.91571144 |
| 112 | Gastrointestinal infarctions (HP:0005244) | 1.90941656 |
| 113 | Asymmetric septal hypertrophy (HP:0001670) | 1.90860170 |
| 114 | Loss of speech (HP:0002371) | 1.87289977 |
| 115 | Basal ganglia calcification (HP:0002135) | 1.86272823 |
| 116 | Abnormality of the peritoneum (HP:0002585) | 1.85097957 |
| 117 | Keratoconjunctivitis sicca (HP:0001097) | 1.83063669 |
| 118 | Neutropenia (HP:0001875) | 1.82798579 |
| 119 | Keratoconjunctivitis (HP:0001096) | 1.80356922 |
| 120 | Small epiphyses (HP:0010585) | 1.80213273 |
| 121 | Ulnar bowing (HP:0003031) | 1.77854769 |
| 122 | Delayed closure of the anterior fontanelle (HP:0001476) | 1.77797028 |
| 123 | Esophageal varix (HP:0002040) | 1.77293773 |
| 124 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.77176435 |
| 125 | Prostate neoplasm (HP:0100787) | 1.76846795 |
| 126 | Aortic valve stenosis (HP:0001650) | 1.75970291 |
| 127 | Urticaria (HP:0001025) | 1.75569948 |
| 128 | Hypochromic anemia (HP:0001931) | 1.75502057 |
| 129 | Acute myeloid leukemia (HP:0004808) | 1.75276426 |
| 130 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.73618089 |
| 131 | Mucopolysacchariduria (HP:0008155) | 1.73618089 |
| 132 | Autoimmune hemolytic anemia (HP:0001890) | 1.73110934 |
| 133 | Pulmonary fibrosis (HP:0002206) | 1.73013324 |
| 134 | Acrocyanosis (HP:0001063) | 1.72240008 |
| 135 | Hemoptysis (HP:0002105) | 1.71989942 |
| 136 | T lymphocytopenia (HP:0005403) | 1.71964959 |
| 137 | Peritonitis (HP:0002586) | 1.71841611 |
| 138 | Mitral valve prolapse (HP:0001634) | 1.70336766 |
| 139 | Glucose intolerance (HP:0000833) | 1.70011522 |
| 140 | Tetraparesis (HP:0002273) | 1.69898783 |
| 141 | Aortic regurgitation (HP:0001659) | 1.69198162 |
| 142 | Teleangiectasia of the skin (HP:0100585) | 1.68701259 |
| 143 | Cerebral aneurysm (HP:0004944) | 1.68072256 |
| 144 | Bladder diverticulum (HP:0000015) | 1.67893319 |
| 145 | Follicular hyperkeratosis (HP:0007502) | 1.64867526 |
| 146 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.64577212 |
| 147 | Nonimmune hydrops fetalis (HP:0001790) | 1.63385529 |
| 148 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.63124926 |
| 149 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.63124926 |
| 150 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.63124926 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K14 | 4.37262168 |
| 2 | MAP4K1 | 4.11639792 |
| 3 | TYK2 | 2.93143954 |
| 4 | MAP3K13 | 2.83230893 |
| 5 | IKBKB | 2.65133062 |
| 6 | JAK3 | 2.62930213 |
| 7 | TBK1 | 2.53055951 |
| 8 | CSF1R | 2.43550777 |
| 9 | BLK | 2.34448750 |
| 10 | PRPF4B | 2.28109353 |
| 11 | IRAK4 | 2.18672826 |
| 12 | STK10 | 2.18299116 |
| 13 | JAK1 | 2.09343264 |
| 14 | ERN1 | 2.08232190 |
| 15 | KIT | 2.07992144 |
| 16 | CHUK | 2.06801568 |
| 17 | SMG1 | 1.95545852 |
| 18 | CDK12 | 1.94961489 |
| 19 | MAP3K10 | 1.92004414 |
| 20 | BTK | 1.91789994 |
| 21 | IRAK3 | 1.85808636 |
| 22 | IKBKE | 1.85531481 |
| 23 | LRRK2 | 1.82365484 |
| 24 | CCNB1 | 1.75718942 |
| 25 | RIPK4 | 1.74720715 |
| 26 | GRK6 | 1.68837356 |
| 27 | NME2 | 1.62038323 |
| 28 | TGFBR2 | 1.52750214 |
| 29 | TAF1 | 1.50389854 |
| 30 | BMPR2 | 1.48354782 |
| 31 | RPS6KA4 | 1.46323096 |
| 32 | * SYK | 1.45812692 |
| 33 | PIM1 | 1.35532491 |
| 34 | DDR2 | 1.31747106 |
| 35 | TEC | 1.27946087 |
| 36 | PDGFRA | 1.25764918 |
| 37 | CDC42BPA | 1.25660547 |
| 38 | EPHB1 | 1.22836556 |
| 39 | CSK | 1.20547399 |
| 40 | NEK9 | 1.16803923 |
| 41 | HCK | 1.14087698 |
| 42 | MAPK7 | 1.13298323 |
| 43 | FGFR3 | 1.10512556 |
| 44 | LYN | 1.08932073 |
| 45 | FLT3 | 1.07930847 |
| 46 | EPHA3 | 1.06303148 |
| 47 | ZAP70 | 1.05697586 |
| 48 | LCK | 1.00971661 |
| 49 | FGFR4 | 1.00616076 |
| 50 | STK4 | 0.99900615 |
| 51 | KDR | 0.96745654 |
| 52 | SIK2 | 0.94761833 |
| 53 | TTN | 0.94655871 |
| 54 | PTK6 | 0.92977115 |
| 55 | EEF2K | 0.92226607 |
| 56 | MATK | 0.92082682 |
| 57 | NEK2 | 0.87415539 |
| 58 | MST4 | 0.84652518 |
| 59 | PIK3CG | 0.82928813 |
| 60 | ITK | 0.82660010 |
| 61 | TGFBR1 | 0.82597549 |
| 62 | CDK8 | 0.80631837 |
| 63 | MARK3 | 0.79972750 |
| 64 | PIM2 | 0.79914658 |
| 65 | MAP3K3 | 0.79004896 |
| 66 | MAP2K3 | 0.76008162 |
| 67 | CDK4 | 0.75929961 |
| 68 | MAP3K8 | 0.75274549 |
| 69 | PAK2 | 0.73554762 |
| 70 | JAK2 | 0.71401237 |
| 71 | MAPKAPK5 | 0.69049139 |
| 72 | BRD4 | 0.67947900 |
| 73 | CAMK1D | 0.67820587 |
| 74 | PDGFRB | 0.67077850 |
| 75 | PKN2 | 0.66414633 |
| 76 | NLK | 0.65664684 |
| 77 | STK3 | 0.65008250 |
| 78 | TRIB3 | 0.64539496 |
| 79 | ALK | 0.63145610 |
| 80 | CDK6 | 0.62957485 |
| 81 | MAPKAPK2 | 0.62165282 |
| 82 | ATR | 0.61056034 |
| 83 | SIK1 | 0.59574200 |
| 84 | BMX | 0.59109319 |
| 85 | PDK2 | 0.58827489 |
| 86 | PRKCQ | 0.58048224 |
| 87 | CAMK1G | 0.57849347 |
| 88 | ABL1 | 0.55436540 |
| 89 | ERBB4 | 0.55274054 |
| 90 | ACVR1B | 0.55089645 |
| 91 | BRSK2 | 0.54525524 |
| 92 | EIF2AK2 | 0.54125819 |
| 93 | CLK1 | 0.53391177 |
| 94 | SIK3 | 0.53094268 |
| 95 | LATS2 | 0.53046285 |
| 96 | FGR | 0.51514679 |
| 97 | EIF2AK3 | 0.50673098 |
| 98 | STK24 | 0.50591979 |
| 99 | MAPK11 | 0.50172531 |
| 100 | GRK1 | 0.48901879 |
| 101 | DYRK3 | 0.48744567 |
| 102 | PRKCD | 0.47903115 |
| 103 | CDC7 | 0.47855273 |
| 104 | EGFR | 0.46226007 |
| 105 | MAPK12 | 0.45554254 |
| 106 | MAPK4 | 0.44731696 |
| 107 | DYRK1B | 0.44450528 |
| 108 | PRKAA2 | 0.44404907 |
| 109 | IRAK2 | 0.44190032 |
| 110 | TAOK3 | 0.41622616 |
| 111 | CDK9 | 0.41393497 |
| 112 | RPS6KB2 | 0.41083454 |
| 113 | CDK3 | 0.40515233 |
| 114 | TESK2 | 0.40490111 |
| 115 | TIE1 | 0.40145798 |
| 116 | DMPK | 0.39859517 |
| 117 | TRPM7 | 0.39830601 |
| 118 | FES | 0.39474281 |
| 119 | MELK | 0.39343918 |
| 120 | PBK | 0.38856367 |
| 121 | RPS6KA5 | 0.36466188 |
| 122 | MYLK | 0.36362189 |
| 123 | HIPK2 | 0.35462418 |
| 124 | INSR | 0.35070554 |
| 125 | TAOK2 | 0.34919399 |
| 126 | RIPK1 | 0.34693558 |
| 127 | PTK2B | 0.34607158 |
| 128 | YES1 | 0.33922646 |
| 129 | NUAK1 | 0.33325357 |
| 130 | SCYL2 | 0.33102903 |
| 131 | MOS | 0.33064427 |
| 132 | PAK4 | 0.32193722 |
| 133 | CHEK1 | 0.29161389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.24947596 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.19651403 |
| 3 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 3.15305589 |
| 4 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.71973358 |
| 5 | Leishmaniasis_Homo sapiens_hsa05140 | 2.56857113 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.33038511 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.20752738 |
| 8 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.18523930 |
| 9 | Measles_Homo sapiens_hsa05162 | 2.13304019 |
| 10 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.07258829 |
| 11 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.00797298 |
| 12 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.91858538 |
| 13 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.89493177 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.85965980 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.82079489 |
| 16 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.75282748 |
| 17 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.71287642 |
| 18 | Apoptosis_Homo sapiens_hsa04210 | 1.68362365 |
| 19 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.67787567 |
| 20 | Influenza A_Homo sapiens_hsa05164 | 1.66360081 |
| 21 | Legionellosis_Homo sapiens_hsa05134 | 1.58461571 |
| 22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.51561052 |
| 23 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.48399450 |
| 24 | Tuberculosis_Homo sapiens_hsa05152 | 1.45613373 |
| 25 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.42056484 |
| 26 | Shigellosis_Homo sapiens_hsa05131 | 1.40737477 |
| 27 | Malaria_Homo sapiens_hsa05144 | 1.37621308 |
| 28 | Viral myocarditis_Homo sapiens_hsa05416 | 1.36579129 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.35826375 |
| 30 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.33897275 |
| 31 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.32225106 |
| 32 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.31829274 |
| 33 | Hepatitis B_Homo sapiens_hsa05161 | 1.30870801 |
| 34 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.26455841 |
| 35 | Pertussis_Homo sapiens_hsa05133 | 1.25316019 |
| 36 | DNA replication_Homo sapiens_hsa03030 | 1.23864176 |
| 37 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.22199302 |
| 38 | Base excision repair_Homo sapiens_hsa03410 | 1.21259470 |
| 39 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.20717069 |
| 40 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.20124020 |
| 41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.17953602 |
| 42 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.17913915 |
| 43 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.17011873 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.15938172 |
| 45 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.13371544 |
| 46 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.12133134 |
| 47 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.09494895 |
| 48 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.08797173 |
| 49 | Bladder cancer_Homo sapiens_hsa05219 | 1.07050614 |
| 50 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.06433157 |
| 51 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.06340511 |
| 52 | Mismatch repair_Homo sapiens_hsa03430 | 1.05248978 |
| 53 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.03729395 |
| 54 | HTLV-I infection_Homo sapiens_hsa05166 | 1.00783658 |
| 55 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.94606656 |
| 56 | Hepatitis C_Homo sapiens_hsa05160 | 0.93394876 |
| 57 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.91674591 |
| 58 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.91084172 |
| 59 | Salmonella infection_Homo sapiens_hsa05132 | 0.90318126 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.89163246 |
| 61 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.88571363 |
| 62 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.82543661 |
| 63 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.81329051 |
| 64 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79184296 |
| 65 | Asthma_Homo sapiens_hsa05310 | 0.76478237 |
| 66 | Platelet activation_Homo sapiens_hsa04611 | 0.74178015 |
| 67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.72643908 |
| 68 | Homologous recombination_Homo sapiens_hsa03440 | 0.72586399 |
| 69 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.71136532 |
| 70 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.70336355 |
| 71 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.67428734 |
| 72 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.66969550 |
| 73 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.65176777 |
| 74 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.65038844 |
| 75 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.64212412 |
| 76 | Cell cycle_Homo sapiens_hsa04110 | 0.63446156 |
| 77 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.62369323 |
| 78 | Ribosome_Homo sapiens_hsa03010 | 0.61807488 |
| 79 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.59675639 |
| 80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.58896642 |
| 81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58132493 |
| 82 | Spliceosome_Homo sapiens_hsa03040 | 0.57672507 |
| 83 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.55193394 |
| 84 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.54950214 |
| 85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.53973916 |
| 86 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53182053 |
| 87 | Adherens junction_Homo sapiens_hsa04520 | 0.51897871 |
| 88 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.48818539 |
| 89 | Prostate cancer_Homo sapiens_hsa05215 | 0.46832321 |
| 90 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.46636850 |
| 91 | Pathways in cancer_Homo sapiens_hsa05200 | 0.45745132 |
| 92 | RNA transport_Homo sapiens_hsa03013 | 0.45597802 |
| 93 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.44260517 |
| 94 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.43644865 |
| 95 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.42930002 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.42194248 |
| 97 | Focal adhesion_Homo sapiens_hsa04510 | 0.41536986 |
| 98 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.40884225 |
| 99 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40673387 |
| 100 | Insulin resistance_Homo sapiens_hsa04931 | 0.39421411 |
| 101 | Lysosome_Homo sapiens_hsa04142 | 0.39011920 |
| 102 | Amoebiasis_Homo sapiens_hsa05146 | 0.38002395 |
| 103 | Colorectal cancer_Homo sapiens_hsa05210 | 0.37974831 |
| 104 | Phagosome_Homo sapiens_hsa04145 | 0.37179151 |
| 105 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.35079422 |
| 106 | Melanoma_Homo sapiens_hsa05218 | 0.34696780 |
| 107 | Other glycan degradation_Homo sapiens_hsa00511 | 0.33924407 |
| 108 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.33290061 |
| 109 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.32968616 |
| 110 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30628038 |
| 111 | Endocytosis_Homo sapiens_hsa04144 | 0.30261857 |
| 112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.29732795 |
| 113 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.29398136 |
| 114 | RNA degradation_Homo sapiens_hsa03018 | 0.28806593 |
| 115 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26427421 |
| 116 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.25148506 |

