

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | COPI coating of Golgi vesicle (GO:0048205) | 5.33988052 |
| 2 | Golgi transport vesicle coating (GO:0048200) | 5.33988052 |
| 3 | protein neddylation (GO:0045116) | 5.11753220 |
| 4 | viral transcription (GO:0019083) | 4.91629129 |
| 5 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.84797300 |
| 6 | translational termination (GO:0006415) | 4.81303299 |
| 7 | ribosomal small subunit assembly (GO:0000028) | 4.81032137 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 4.72998901 |
| 9 | protein targeting to ER (GO:0045047) | 4.71711907 |
| 10 | DNA deamination (GO:0045006) | 4.59567337 |
| 11 | translational elongation (GO:0006414) | 4.55362353 |
| 12 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.49413897 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 4.49405813 |
| 14 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.42586480 |
| 15 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.29449373 |
| 16 | translational initiation (GO:0006413) | 4.03955468 |
| 17 | regulation of mitochondrial translation (GO:0070129) | 3.92653558 |
| 18 | cellular protein complex disassembly (GO:0043624) | 3.92023130 |
| 19 | ATP synthesis coupled proton transport (GO:0015986) | 3.91795856 |
| 20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.91795856 |
| 21 | ribosomal small subunit biogenesis (GO:0042274) | 3.91648045 |
| 22 | viral life cycle (GO:0019058) | 3.89616786 |
| 23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.85196733 |
| 24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.85196733 |
| 25 | NADH dehydrogenase complex assembly (GO:0010257) | 3.85196733 |
| 26 | translation (GO:0006412) | 3.81370091 |
| 27 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.79565162 |
| 28 | formation of translation preinitiation complex (GO:0001731) | 3.78276439 |
| 29 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.70477308 |
| 30 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.69543157 |
| 31 | rRNA modification (GO:0000154) | 3.66994500 |
| 32 | oxidative phosphorylation (GO:0006119) | 3.58041082 |
| 33 | maturation of SSU-rRNA (GO:0030490) | 3.57402067 |
| 34 | establishment of integrated proviral latency (GO:0075713) | 3.51294462 |
| 35 | protein maturation by protein folding (GO:0022417) | 3.49290051 |
| 36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.48828146 |
| 37 | protein complex disassembly (GO:0043241) | 3.45604271 |
| 38 | ATP biosynthetic process (GO:0006754) | 3.43940931 |
| 39 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.43652704 |
| 40 | termination of RNA polymerase III transcription (GO:0006386) | 3.43652704 |
| 41 | negative regulation of ligase activity (GO:0051352) | 3.42534934 |
| 42 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.42534934 |
| 43 | ribosomal large subunit biogenesis (GO:0042273) | 3.42123829 |
| 44 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.40818565 |
| 45 | proteasome assembly (GO:0043248) | 3.40710599 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.40688221 |
| 47 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.38734350 |
| 48 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.33795054 |
| 49 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.33703725 |
| 50 | inner mitochondrial membrane organization (GO:0007007) | 3.33443356 |
| 51 | macromolecular complex disassembly (GO:0032984) | 3.31091718 |
| 52 | tricarboxylic acid cycle (GO:0006099) | 3.26253060 |
| 53 | protein targeting to membrane (GO:0006612) | 3.25999398 |
| 54 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.23922383 |
| 55 | regulation of protein heterodimerization activity (GO:0043497) | 3.23569046 |
| 56 | 7-methylguanosine mRNA capping (GO:0006370) | 3.22520127 |
| 57 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.21908543 |
| 58 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.19759918 |
| 59 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.19608653 |
| 60 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.17803607 |
| 61 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.17181377 |
| 62 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.16194709 |
| 63 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.16194709 |
| 64 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.16022468 |
| 65 | respiratory electron transport chain (GO:0022904) | 3.14959301 |
| 66 | regulation of cellular amine metabolic process (GO:0033238) | 3.14565058 |
| 67 | 7-methylguanosine RNA capping (GO:0009452) | 3.12073289 |
| 68 | RNA capping (GO:0036260) | 3.12073289 |
| 69 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.11469174 |
| 70 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.11469174 |
| 71 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.11469174 |
| 72 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.11067572 |
| 73 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.10962449 |
| 74 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.10621921 |
| 75 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.10413646 |
| 76 | electron transport chain (GO:0022900) | 3.10210640 |
| 77 | cullin deneddylation (GO:0010388) | 3.09722315 |
| 78 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.09391529 |
| 79 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.09391529 |
| 80 | nucleobase biosynthetic process (GO:0046112) | 3.09094336 |
| 81 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.09036389 |
| 82 | protein deneddylation (GO:0000338) | 3.08444344 |
| 83 | protein retention in ER lumen (GO:0006621) | 3.08145142 |
| 84 | regulation of ligase activity (GO:0051340) | 3.08023851 |
| 85 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.06913065 |
| 86 | hydrogen ion transmembrane transport (GO:1902600) | 3.05057334 |
| 87 | spliceosomal snRNP assembly (GO:0000387) | 3.03397116 |
| 88 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.03114071 |
| 89 | mitochondrial transport (GO:0006839) | 3.02548493 |
| 90 | GTP biosynthetic process (GO:0006183) | 3.01666444 |
| 91 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.01144635 |
| 92 | de novo protein folding (GO:0006458) | 3.00911936 |
| 93 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.00853438 |
| 94 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.98840290 |
| 95 | rRNA methylation (GO:0031167) | 2.98104327 |
| 96 | positive regulation of ligase activity (GO:0051351) | 2.97146269 |
| 97 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.95261555 |
| 98 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.95261555 |
| 99 | platelet dense granule organization (GO:0060155) | 2.95166810 |
| 100 | establishment of protein localization to mitochondrion (GO:0072655) | 2.94078121 |
| 101 | chaperone-mediated protein transport (GO:0072321) | 2.93031831 |
| 102 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.92576289 |
| 103 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.92576289 |
| 104 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.90787331 |
| 105 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.90787331 |
| 106 | de novo posttranslational protein folding (GO:0051084) | 2.90442233 |
| 107 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.89635378 |
| 108 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.88919395 |
| 109 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.88919395 |
| 110 | regulation of oxidative phosphorylation (GO:0002082) | 2.88675576 |
| 111 | pentose-phosphate shunt (GO:0006098) | 2.88673607 |
| 112 | proline biosynthetic process (GO:0006561) | 2.88156838 |
| 113 | CENP-A containing nucleosome assembly (GO:0034080) | 2.87970779 |
| 114 | peptidyl-histidine modification (GO:0018202) | 2.87936956 |
| 115 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.87825525 |
| 116 | respiratory chain complex IV assembly (GO:0008535) | 2.87572866 |
| 117 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.87202030 |
| 118 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.86464240 |
| 119 | GDP-mannose metabolic process (GO:0019673) | 2.84519480 |
| 120 | protein targeting to mitochondrion (GO:0006626) | 2.83605428 |
| 121 | purine nucleobase biosynthetic process (GO:0009113) | 2.83279646 |
| 122 | DNA strand elongation (GO:0022616) | 2.82459140 |
| 123 | cellular component biogenesis (GO:0044085) | 2.80768894 |
| 124 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.80607818 |
| 125 | tRNA aminoacylation for protein translation (GO:0006418) | 2.79871348 |
| 126 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.78132976 |
| 127 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.78122363 |
| 128 | chaperone-mediated protein complex assembly (GO:0051131) | 2.78079747 |
| 129 | spliceosomal complex assembly (GO:0000245) | 2.75757809 |
| 130 | protein localization to mitochondrion (GO:0070585) | 2.74592194 |
| 131 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.74244852 |
| 132 | protein complex biogenesis (GO:0070271) | 2.73498915 |
| 133 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.72753810 |
| 134 | establishment of viral latency (GO:0019043) | 2.71651261 |
| 135 | amino acid activation (GO:0043038) | 2.71505777 |
| 136 | tRNA aminoacylation (GO:0043039) | 2.71505777 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.57673269 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.33465444 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.91153864 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.74954759 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.72337392 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.58901248 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.41083688 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.39106497 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.33164987 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.19708350 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.09072825 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.08116346 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.03572808 |
| 14 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.97929341 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.80733371 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.73707608 |
| 17 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.63852987 |
| 18 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.52170074 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44620713 |
| 20 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.41015057 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.34048013 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.33959637 |
| 23 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.24816558 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.24508060 |
| 25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.20125424 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.18936977 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.14850933 |
| 28 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.14042746 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.10220414 |
| 30 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.09980420 |
| 31 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.06116956 |
| 32 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.01048995 |
| 33 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 2.00315031 |
| 34 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90395316 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.86085169 |
| 36 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.81704002 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.79325639 |
| 38 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.77380423 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.75480823 |
| 40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.73745640 |
| 41 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70101221 |
| 42 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.69232774 |
| 43 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.69005222 |
| 44 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.64671252 |
| 45 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.64298629 |
| 46 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.57674353 |
| 47 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57175078 |
| 48 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.57066212 |
| 49 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.53282073 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.52360614 |
| 51 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51743171 |
| 52 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.49425174 |
| 53 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.49029117 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.46986026 |
| 55 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.44909758 |
| 56 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.36727544 |
| 57 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36399920 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.36142466 |
| 59 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.36060940 |
| 60 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35085185 |
| 61 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.33672197 |
| 62 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.33563292 |
| 63 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.33088381 |
| 64 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.32021938 |
| 65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.31123241 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.31032439 |
| 67 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.30450972 |
| 68 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.30418628 |
| 69 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29881782 |
| 70 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.28681948 |
| 71 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.27640609 |
| 72 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.27049690 |
| 73 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25640410 |
| 74 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.25253443 |
| 75 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22104682 |
| 76 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.19825847 |
| 77 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.19700938 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.17524576 |
| 79 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17424355 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17285703 |
| 81 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.16150753 |
| 82 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.14880584 |
| 83 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.13930002 |
| 84 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12931501 |
| 85 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.10834279 |
| 86 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.09477283 |
| 87 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.07462293 |
| 88 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.07021888 |
| 89 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.06272885 |
| 90 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.04900708 |
| 91 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.02659130 |
| 92 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.01403377 |
| 93 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99716190 |
| 94 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.99055581 |
| 95 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.98295380 |
| 96 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93787833 |
| 97 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.93521069 |
| 98 | MYC_22102868_ChIP-Seq_BL_Human | 0.93336622 |
| 99 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.93274205 |
| 100 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.92340603 |
| 101 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.88912687 |
| 102 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.88907029 |
| 103 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.87807463 |
| 104 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.87662363 |
| 105 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.87435276 |
| 106 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.86338345 |
| 107 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.85841368 |
| 108 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.82937055 |
| 109 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80449741 |
| 110 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.79222146 |
| 111 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.77974862 |
| 112 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.76653584 |
| 113 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.75391864 |
| 114 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.71412877 |
| 115 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.69783117 |
| 116 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.69125807 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.21770043 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.04524218 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.61969176 |
| 4 | MP0000372_irregular_coat_pigmentation | 3.54927227 |
| 5 | MP0003136_yellow_coat_color | 2.86591941 |
| 6 | MP0006036_abnormal_mitochondrial_physio | 2.81557044 |
| 7 | MP0002837_dystrophic_cardiac_calcinosis | 2.66392029 |
| 8 | MP0003123_paternal_imprinting | 2.56420507 |
| 9 | MP0003077_abnormal_cell_cycle | 2.41181480 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.39683748 |
| 11 | MP0009697_abnormal_copulation | 2.38768051 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.32197210 |
| 13 | MP0003111_abnormal_nucleus_morphology | 2.25195949 |
| 14 | MP0010094_abnormal_chromosome_stability | 2.20605602 |
| 15 | MP0002139_abnormal_hepatobiliary_system | 2.18402706 |
| 16 | MP0005220_abnormal_exocrine_pancreas | 2.17727509 |
| 17 | MP0008438_abnormal_cutaneous_collagen | 2.10567503 |
| 18 | MP0003186_abnormal_redox_activity | 2.10447664 |
| 19 | MP0000358_abnormal_cell_content/ | 2.09907959 |
| 20 | MP0009379_abnormal_foot_pigmentation | 2.03331404 |
| 21 | MP0005083_abnormal_biliary_tract | 2.00767003 |
| 22 | MP0008995_early_reproductive_senescence | 1.93375633 |
| 23 | MP0002653_abnormal_ependyma_morphology | 1.88995646 |
| 24 | MP0006035_abnormal_mitochondrial_morpho | 1.86537158 |
| 25 | MP0000013_abnormal_adipose_tissue | 1.80668936 |
| 26 | MP0006054_spinal_hemorrhage | 1.74370563 |
| 27 | MP0003646_muscle_fatigue | 1.71383537 |
| 28 | MP0008007_abnormal_cellular_replicative | 1.70556149 |
| 29 | MP0005464_abnormal_platelet_physiology | 1.66795082 |
| 30 | MP0000750_abnormal_muscle_regeneration | 1.62379830 |
| 31 | MP0001730_embryonic_growth_arrest | 1.62135135 |
| 32 | MP0003011_delayed_dark_adaptation | 1.60994728 |
| 33 | MP0002736_abnormal_nociception_after | 1.60287881 |
| 34 | MP0002132_abnormal_respiratory_system | 1.60103870 |
| 35 | MP0002877_abnormal_melanocyte_morpholog | 1.58522823 |
| 36 | MP0008058_abnormal_DNA_repair | 1.55189210 |
| 37 | MP0002160_abnormal_reproductive_system | 1.49315752 |
| 38 | MP0002269_muscular_atrophy | 1.46168690 |
| 39 | MP0008789_abnormal_olfactory_epithelium | 1.44192507 |
| 40 | MP0004233_abnormal_muscle_weight | 1.42962511 |
| 41 | MP0008877_abnormal_DNA_methylation | 1.40581847 |
| 42 | MP0001944_abnormal_pancreas_morphology | 1.39648264 |
| 43 | MP0002909_abnormal_adrenal_gland | 1.38693036 |
| 44 | MP0003195_calcinosis | 1.37912128 |
| 45 | MP0005408_hypopigmentation | 1.36480700 |
| 46 | MP0003283_abnormal_digestive_organ | 1.35278783 |
| 47 | MP0002080_prenatal_lethality | 1.26864094 |
| 48 | MP0001697_abnormal_embryo_size | 1.24522645 |
| 49 | MP0008004_abnormal_stomach_pH | 1.23492997 |
| 50 | MP0003718_maternal_effect | 1.23347793 |
| 51 | MP0003786_premature_aging | 1.22964030 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.21659544 |
| 53 | MP0005499_abnormal_olfactory_system | 1.21659544 |
| 54 | MP0005365_abnormal_bile_salt | 1.20497970 |
| 55 | MP0004084_abnormal_cardiac_muscle | 1.19383870 |
| 56 | MP0003221_abnormal_cardiomyocyte_apopto | 1.18035465 |
| 57 | MP0000653_abnormal_sex_gland | 1.17708800 |
| 58 | MP0004147_increased_porphyrin_level | 1.17577006 |
| 59 | MP0001293_anophthalmia | 1.16983207 |
| 60 | MP0004043_abnormal_pH_regulation | 1.16421863 |
| 61 | MP0003656_abnormal_erythrocyte_physiolo | 1.16340082 |
| 62 | MP0000350_abnormal_cell_proliferation | 1.15365901 |
| 63 | MP0002638_abnormal_pupillary_reflex | 1.12540285 |
| 64 | MP0000678_abnormal_parathyroid_gland | 1.12327575 |
| 65 | MP0005636_abnormal_mineral_homeostasis | 1.12273345 |
| 66 | MP0000647_abnormal_sebaceous_gland | 1.11893050 |
| 67 | MP0010030_abnormal_orbit_morphology | 1.11681041 |
| 68 | MP0001905_abnormal_dopamine_level | 1.11516445 |
| 69 | MP0003698_abnormal_male_reproductive | 1.10741546 |
| 70 | MP0005503_abnormal_tendon_morphology | 1.09587758 |
| 71 | MP0005275_abnormal_skin_tensile | 1.08414791 |
| 72 | MP0002295_abnormal_pulmonary_circulatio | 1.08347200 |
| 73 | MP0009643_abnormal_urine_homeostasis | 1.06162691 |
| 74 | MP0003941_abnormal_skin_development | 1.05717384 |
| 75 | MP0001756_abnormal_urination | 1.04142314 |
| 76 | MP0005171_absent_coat_pigmentation | 1.02156346 |
| 77 | MP0004142_abnormal_muscle_tone | 1.02001182 |
| 78 | MP0001661_extended_life_span | 1.00056731 |
| 79 | MP0002234_abnormal_pharynx_morphology | 0.99579785 |
| 80 | MP0001529_abnormal_vocalization | 0.99401424 |
| 81 | MP0008875_abnormal_xenobiotic_pharmacok | 0.99264607 |
| 82 | MP0000749_muscle_degeneration | 0.99070529 |
| 83 | MP0005367_renal/urinary_system_phenotyp | 0.98281196 |
| 84 | MP0000516_abnormal_urinary_system | 0.98281196 |
| 85 | MP0003315_abnormal_perineum_morphology | 0.97979519 |
| 86 | MP0003705_abnormal_hypodermis_morpholog | 0.97851296 |
| 87 | MP0003942_abnormal_urinary_system | 0.97389283 |
| 88 | MP0005389_reproductive_system_phenotype | 0.96796804 |
| 89 | MP0002085_abnormal_embryonic_tissue | 0.96187084 |
| 90 | MP0009672_abnormal_birth_weight | 0.95556904 |
| 91 | MP0001984_abnormal_olfaction | 0.95352386 |
| 92 | MP0003959_abnormal_lean_body | 0.94956445 |
| 93 | MP0010386_abnormal_urinary_bladder | 0.94867200 |
| 94 | MP0006276_abnormal_autonomic_nervous | 0.94802782 |
| 95 | MP0005266_abnormal_metabolism | 0.94243173 |
| 96 | MP0005670_abnormal_white_adipose | 0.94090909 |
| 97 | MP0000747_muscle_weakness | 0.93053819 |
| 98 | MP0002693_abnormal_pancreas_physiology | 0.93037788 |
| 99 | MP0000751_myopathy | 0.92540888 |
| 100 | MP0002163_abnormal_gland_morphology | 0.92186426 |
| 101 | MP0003868_abnormal_feces_composition | 0.91785628 |
| 102 | MP0002102_abnormal_ear_morphology | 0.91375633 |
| 103 | MP0001727_abnormal_embryo_implantation | 0.91263011 |
| 104 | MP0002078_abnormal_glucose_homeostasis | 0.90928179 |
| 105 | MP0004133_heterotaxia | 0.90158356 |
| 106 | MP0002084_abnormal_developmental_patter | 0.89736813 |
| 107 | MP0004197_abnormal_fetal_growth/weight/ | 0.89418977 |
| 108 | MP0001348_abnormal_lacrimal_gland | 0.89339339 |
| 109 | MP0005332_abnormal_amino_acid | 0.89338254 |
| 110 | MP0002938_white_spotting | 0.88513220 |
| 111 | MP0002751_abnormal_autonomic_nervous | 0.88307788 |
| 112 | MP0000313_abnormal_cell_death | 0.87856258 |
| 113 | MP0002210_abnormal_sex_determination | 0.87690938 |
| 114 | MP0003567_abnormal_fetal_cardiomyocyte | 0.87151678 |
| 115 | MP0001929_abnormal_gametogenesis | 0.86852366 |
| 116 | MP0002970_abnormal_white_adipose | 0.86665426 |
| 117 | MP0005501_abnormal_skin_physiology | 0.86049106 |
| 118 | MP0001145_abnormal_male_reproductive | 0.85726749 |
| 119 | MP0000631_abnormal_neuroendocrine_gland | 0.84375470 |
| 120 | MP0004019_abnormal_vitamin_homeostasis | 0.82621125 |
| 121 | MP0008872_abnormal_physiological_respon | 0.82584698 |
| 122 | MP0005666_abnormal_adipose_tissue | 0.82518871 |
| 123 | MP0005075_abnormal_melanosome_morpholog | 0.82512148 |
| 124 | MP0005085_abnormal_gallbladder_physiolo | 0.81579576 |
| 125 | MP0010352_gastrointestinal_tract_polyps | 0.80799005 |
| 126 | MP0005380_embryogenesis_phenotype | 0.80388655 |
| 127 | MP0001672_abnormal_embryogenesis/_devel | 0.80388655 |
| 128 | MP0006072_abnormal_retinal_apoptosis | 0.80384609 |
| 129 | MP0002019_abnormal_tumor_incidence | 0.79660334 |
| 130 | MP0002161_abnormal_fertility/fecundity | 0.78101381 |
| 131 | MP0005410_abnormal_fertilization | 0.77816977 |
| 132 | MP0000049_abnormal_middle_ear | 0.77762284 |
| 133 | MP0003937_abnormal_limbs/digits/tail_de | 0.77110531 |
| 134 | MP0005319_abnormal_enzyme/_coenzyme | 0.76821796 |
| 135 | MP0005084_abnormal_gallbladder_morpholo | 0.76732320 |
| 136 | MP0005379_endocrine/exocrine_gland_phen | 0.76542218 |
| 137 | MP0000537_abnormal_urethra_morphology | 0.75846383 |
| 138 | MP0004215_abnormal_myocardial_fiber | 0.75778441 |
| 139 | MP0000343_altered_response_to | 0.75501667 |
| 140 | MP0001764_abnormal_homeostasis | 0.74788503 |
| 141 | MP0001286_abnormal_eye_development | 0.74364485 |
| 142 | MP0001119_abnormal_female_reproductive | 0.68400546 |
| 143 | MP0001881_abnormal_mammary_gland | 0.67496780 |
| 144 | MP0005377_hearing/vestibular/ear_phenot | 0.66076690 |
| 145 | MP0003878_abnormal_ear_physiology | 0.66076690 |
| 146 | MP0002095_abnormal_skin_pigmentation | 0.65886470 |
| 147 | MP0002282_abnormal_trachea_morphology | 0.65062059 |
| 148 | MP0001968_abnormal_touch/_nociception | 0.62755546 |
| 149 | MP0002697_abnormal_eye_size | 0.61303161 |
| 150 | MP0002233_abnormal_nose_morphology | 0.61025536 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.70604316 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.69271546 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.51187260 |
| 4 | Hepatic necrosis (HP:0002605) | 4.38301953 |
| 5 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.32271461 |
| 6 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.32271461 |
| 7 | Renal Fanconi syndrome (HP:0001994) | 4.29009257 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.22934150 |
| 9 | Acute encephalopathy (HP:0006846) | 4.20839983 |
| 10 | Mitochondrial inheritance (HP:0001427) | 4.08351225 |
| 11 | Abnormal number of erythroid precursors (HP:0012131) | 3.90635857 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.87021572 |
| 13 | Increased CSF lactate (HP:0002490) | 3.86552264 |
| 14 | Abnormality of glycolysis (HP:0004366) | 3.61591821 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.61591821 |
| 16 | Progressive macrocephaly (HP:0004481) | 3.51882599 |
| 17 | Cerebral edema (HP:0002181) | 3.41872155 |
| 18 | Reticulocytopenia (HP:0001896) | 3.34518238 |
| 19 | Hypoglycemic coma (HP:0001325) | 3.31716419 |
| 20 | Lactic acidosis (HP:0003128) | 3.21452181 |
| 21 | Aplastic anemia (HP:0001915) | 3.16212723 |
| 22 | Increased muscle lipid content (HP:0009058) | 3.03759190 |
| 23 | Multiple enchondromatosis (HP:0005701) | 3.03509408 |
| 24 | Exertional dyspnea (HP:0002875) | 2.99129290 |
| 25 | Increased serum lactate (HP:0002151) | 2.94780959 |
| 26 | Increased intramyocellular lipid droplets (HP:0012240) | 2.88978837 |
| 27 | Respiratory failure (HP:0002878) | 2.88736809 |
| 28 | Exercise intolerance (HP:0003546) | 2.87559450 |
| 29 | Neuroendocrine neoplasm (HP:0100634) | 2.85997074 |
| 30 | Pheochromocytoma (HP:0002666) | 2.80868531 |
| 31 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.79794252 |
| 32 | Lipid accumulation in hepatocytes (HP:0006561) | 2.78934196 |
| 33 | Myoglobinuria (HP:0002913) | 2.77153396 |
| 34 | Macrocytic anemia (HP:0001972) | 2.73297478 |
| 35 | Emotional lability (HP:0000712) | 2.65067733 |
| 36 | Progressive muscle weakness (HP:0003323) | 2.63587640 |
| 37 | Oral leukoplakia (HP:0002745) | 2.59766532 |
| 38 | Pallor (HP:0000980) | 2.58460842 |
| 39 | Petechiae (HP:0000967) | 2.55442933 |
| 40 | Abnormality of renal resorption (HP:0011038) | 2.53568007 |
| 41 | Ragged-red muscle fibers (HP:0003200) | 2.52954775 |
| 42 | Selective tooth agenesis (HP:0001592) | 2.52111437 |
| 43 | Ketoacidosis (HP:0001993) | 2.51162908 |
| 44 | Increased hepatocellular lipid droplets (HP:0006565) | 2.49621652 |
| 45 | Rhabdomyolysis (HP:0003201) | 2.47693204 |
| 46 | Carpal bone hypoplasia (HP:0001498) | 2.46013967 |
| 47 | Respiratory difficulties (HP:0002880) | 2.43840974 |
| 48 | Late onset (HP:0003584) | 2.43798026 |
| 49 | Degeneration of anterior horn cells (HP:0002398) | 2.41239357 |
| 50 | Abnormality of the anterior horn cell (HP:0006802) | 2.41239357 |
| 51 | Protrusio acetabuli (HP:0003179) | 2.39895097 |
| 52 | Missing ribs (HP:0000921) | 2.36136083 |
| 53 | Lethargy (HP:0001254) | 2.34142064 |
| 54 | CNS demyelination (HP:0007305) | 2.33929043 |
| 55 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.33700263 |
| 56 | Ketosis (HP:0001946) | 2.32295219 |
| 57 | 11 pairs of ribs (HP:0000878) | 2.31899190 |
| 58 | Abnormality of methionine metabolism (HP:0010901) | 2.30851257 |
| 59 | Abnormal hemoglobin (HP:0011902) | 2.30220600 |
| 60 | Dicarboxylic aciduria (HP:0003215) | 2.30087754 |
| 61 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.30087754 |
| 62 | Neoplasm of the adrenal gland (HP:0100631) | 2.28095307 |
| 63 | Palpitations (HP:0001962) | 2.24833080 |
| 64 | Abnormal protein glycosylation (HP:0012346) | 2.22028548 |
| 65 | Abnormal glycosylation (HP:0012345) | 2.22028548 |
| 66 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.22028548 |
| 67 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.22028548 |
| 68 | Hypoplasia of the pons (HP:0012110) | 2.21634076 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.20022749 |
| 70 | Abnormal pupillary function (HP:0007686) | 2.19173858 |
| 71 | Glycosuria (HP:0003076) | 2.18884696 |
| 72 | Abnormality of urine glucose concentration (HP:0011016) | 2.18884696 |
| 73 | Generalized aminoaciduria (HP:0002909) | 2.17955924 |
| 74 | Leukodystrophy (HP:0002415) | 2.14311803 |
| 75 | X-linked dominant inheritance (HP:0001423) | 2.13946319 |
| 76 | Microretrognathia (HP:0000308) | 2.10772909 |
| 77 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.03763704 |
| 78 | Poor head control (HP:0002421) | 2.03606471 |
| 79 | Concave nail (HP:0001598) | 2.03024754 |
| 80 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.02751383 |
| 81 | Medial flaring of the eyebrow (HP:0010747) | 2.01643172 |
| 82 | Secondary amenorrhea (HP:0000869) | 2.01576370 |
| 83 | Abnormality of alanine metabolism (HP:0010916) | 2.01208768 |
| 84 | Hyperalaninemia (HP:0003348) | 2.01208768 |
| 85 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.01208768 |
| 86 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.99586047 |
| 87 | Hyperphosphaturia (HP:0003109) | 1.99307878 |
| 88 | Microvesicular hepatic steatosis (HP:0001414) | 1.98589972 |
| 89 | Myotonia (HP:0002486) | 1.97018968 |
| 90 | Cerebral hypomyelination (HP:0006808) | 1.95410910 |
| 91 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.95122921 |
| 92 | Adenoma sebaceum (HP:0009720) | 1.94724052 |
| 93 | Angiofibromas (HP:0010615) | 1.94724052 |
| 94 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.92794794 |
| 95 | Median cleft lip (HP:0000161) | 1.90972959 |
| 96 | Pancytopenia (HP:0001876) | 1.89523860 |
| 97 | Congenital, generalized hypertrichosis (HP:0004540) | 1.89087096 |
| 98 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.88490745 |
| 99 | Meckel diverticulum (HP:0002245) | 1.86204488 |
| 100 | Absent thumb (HP:0009777) | 1.85736165 |
| 101 | Hyperthyroidism (HP:0000836) | 1.85357405 |
| 102 | Vertebral compression fractures (HP:0002953) | 1.84923292 |
| 103 | Type I transferrin isoform profile (HP:0003642) | 1.84793816 |
| 104 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.84705154 |
| 105 | Pancreatic fibrosis (HP:0100732) | 1.83885223 |
| 106 | Abnormal ciliary motility (HP:0012262) | 1.83572647 |
| 107 | Conjunctival hamartoma (HP:0100780) | 1.83413350 |
| 108 | Cerebellar dysplasia (HP:0007033) | 1.83076816 |
| 109 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.82849870 |
| 110 | Hypoplastic pelvis (HP:0008839) | 1.82847001 |
| 111 | Testicular atrophy (HP:0000029) | 1.81809404 |
| 112 | Abnormal cartilage morphology (HP:0002763) | 1.81484497 |
| 113 | Spastic diplegia (HP:0001264) | 1.81289920 |
| 114 | Sparse eyelashes (HP:0000653) | 1.80077391 |
| 115 | Horseshoe kidney (HP:0000085) | 1.79802566 |
| 116 | Orthostatic hypotension (HP:0001278) | 1.79112339 |
| 117 | Paralysis (HP:0003470) | 1.77694372 |
| 118 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.76520801 |
| 119 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.75976316 |
| 120 | Blindness (HP:0000618) | 1.75954605 |
| 121 | Nausea (HP:0002018) | 1.74799254 |
| 122 | Congenital primary aphakia (HP:0007707) | 1.74784005 |
| 123 | Abnormality of the pons (HP:0007361) | 1.74741022 |
| 124 | Septo-optic dysplasia (HP:0100842) | 1.73782895 |
| 125 | Abnormality of the ileum (HP:0001549) | 1.73685411 |
| 126 | Hypercortisolism (HP:0001578) | 1.73636378 |
| 127 | Reduced antithrombin III activity (HP:0001976) | 1.73420275 |
| 128 | Absent septum pellucidum (HP:0001331) | 1.73065366 |
| 129 | Menorrhagia (HP:0000132) | 1.72545062 |
| 130 | Trismus (HP:0000211) | 1.72247133 |
| 131 | Abnormal gallbladder physiology (HP:0012438) | 1.71025461 |
| 132 | Cholecystitis (HP:0001082) | 1.71025461 |
| 133 | Optic disc pallor (HP:0000543) | 1.70871317 |
| 134 | Abnormality of the preputium (HP:0100587) | 1.70781371 |
| 135 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.70599792 |
| 136 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.70599792 |
| 137 | Gout (HP:0001997) | 1.70145469 |
| 138 | Facial cleft (HP:0002006) | 1.70012237 |
| 139 | Hyperammonemia (HP:0001987) | 1.69187770 |
| 140 | Type II lissencephaly (HP:0007260) | 1.68378763 |
| 141 | Rough bone trabeculation (HP:0100670) | 1.68361886 |
| 142 | Hypoglycemic seizures (HP:0002173) | 1.67384050 |
| 143 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.67263061 |
| 144 | Insulin resistance (HP:0000855) | 1.66573216 |
| 145 | Methylmalonic aciduria (HP:0012120) | 1.66557981 |
| 146 | Bifid tongue (HP:0010297) | 1.64757099 |
| 147 | Slender long bone (HP:0003100) | 1.63715060 |
| 148 | Colon cancer (HP:0003003) | 1.62683508 |
| 149 | Abnormality of reticulocytes (HP:0004312) | 1.61625969 |
| 150 | Abnormality of dentin (HP:0010299) | 1.60850229 |
| 151 | Beaking of vertebral bodies (HP:0004568) | 1.60629397 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.79462918 |
| 2 | BUB1 | 3.40202517 |
| 3 | PBK | 3.34853074 |
| 4 | NME2 | 3.26513836 |
| 5 | TESK1 | 3.16542116 |
| 6 | TESK2 | 3.12044203 |
| 7 | MST4 | 3.01362349 |
| 8 | NEK1 | 2.98418112 |
| 9 | STK16 | 2.95473591 |
| 10 | BCKDK | 2.70768340 |
| 11 | PASK | 2.63542914 |
| 12 | SCYL2 | 2.54471922 |
| 13 | MAPKAPK3 | 2.40189072 |
| 14 | EIF2AK3 | 2.32805380 |
| 15 | EIF2AK1 | 2.30681854 |
| 16 | WEE1 | 2.30350493 |
| 17 | PDK4 | 2.28370967 |
| 18 | PDK3 | 2.28370967 |
| 19 | TRIB3 | 2.14744706 |
| 20 | ZAK | 2.07486919 |
| 21 | PKN2 | 2.04240652 |
| 22 | LIMK1 | 2.02574513 |
| 23 | CDC7 | 1.93307401 |
| 24 | FLT3 | 1.91713731 |
| 25 | EEF2K | 1.84748323 |
| 26 | RPS6KB2 | 1.73153818 |
| 27 | NUAK1 | 1.71433299 |
| 28 | VRK1 | 1.58419188 |
| 29 | LRRK2 | 1.53695750 |
| 30 | TRIM28 | 1.50008631 |
| 31 | BRSK2 | 1.43936594 |
| 32 | ERN1 | 1.40741025 |
| 33 | SRPK1 | 1.39937407 |
| 34 | PAK4 | 1.36122299 |
| 35 | ILK | 1.30198383 |
| 36 | LATS2 | 1.29895704 |
| 37 | NEK2 | 1.28260147 |
| 38 | DYRK3 | 1.24726576 |
| 39 | PIM2 | 1.22141793 |
| 40 | TLK1 | 1.18223435 |
| 41 | AURKA | 1.17567651 |
| 42 | BMPR1B | 1.13189760 |
| 43 | TSSK6 | 1.13109090 |
| 44 | ARAF | 1.09825908 |
| 45 | BRAF | 1.08766938 |
| 46 | AURKB | 1.05738830 |
| 47 | BRSK1 | 1.04343682 |
| 48 | MAP4K2 | 1.04315621 |
| 49 | ACVR1B | 1.04029996 |
| 50 | TTK | 1.03605018 |
| 51 | PDK2 | 1.03583082 |
| 52 | PLK1 | 1.02060574 |
| 53 | MYLK | 1.01749105 |
| 54 | MAP3K12 | 0.99831756 |
| 55 | NME1 | 0.99631031 |
| 56 | PIK3CG | 0.97711030 |
| 57 | MAPK15 | 0.96926706 |
| 58 | EPHB2 | 0.96287095 |
| 59 | PNCK | 0.95504469 |
| 60 | MAP3K11 | 0.94832510 |
| 61 | EPHA2 | 0.93701237 |
| 62 | TTN | 0.93408867 |
| 63 | PLK2 | 0.92648469 |
| 64 | MAP3K8 | 0.91087094 |
| 65 | CSNK1G1 | 0.90004910 |
| 66 | TAF1 | 0.89826785 |
| 67 | BMX | 0.88232456 |
| 68 | STK4 | 0.87916257 |
| 69 | KDR | 0.83669408 |
| 70 | RPS6KA4 | 0.82322374 |
| 71 | CSNK1G2 | 0.80449427 |
| 72 | WNK3 | 0.80427716 |
| 73 | PRKCI | 0.75685501 |
| 74 | PAK1 | 0.74236267 |
| 75 | MAP2K7 | 0.73268376 |
| 76 | DAPK3 | 0.72192825 |
| 77 | DAPK1 | 0.71041051 |
| 78 | LMTK2 | 0.70570330 |
| 79 | ATR | 0.70555914 |
| 80 | CDK7 | 0.68529114 |
| 81 | TNIK | 0.67484713 |
| 82 | CSNK1A1L | 0.65494709 |
| 83 | DYRK2 | 0.64998422 |
| 84 | PDGFRA | 0.62652033 |
| 85 | TGFBR1 | 0.61195996 |
| 86 | CCNB1 | 0.60371570 |
| 87 | PLK4 | 0.59604947 |
| 88 | IRAK3 | 0.57064160 |
| 89 | WNK4 | 0.56209869 |
| 90 | CSNK2A2 | 0.55496296 |
| 91 | GRK1 | 0.55470560 |
| 92 | ABL2 | 0.53901387 |
| 93 | CDK19 | 0.53556627 |
| 94 | CDK8 | 0.53355722 |
| 95 | MET | 0.53141071 |
| 96 | CSNK1G3 | 0.52949993 |
| 97 | STK38L | 0.52865068 |
| 98 | CAMKK2 | 0.50947474 |
| 99 | PLK3 | 0.50432117 |
| 100 | CSNK2A1 | 0.50403317 |
| 101 | TAOK2 | 0.48376174 |
| 102 | CLK1 | 0.48123842 |
| 103 | MAPKAPK5 | 0.46597406 |
| 104 | PRKD3 | 0.46241184 |
| 105 | SIK1 | 0.46000232 |
| 106 | ADRBK2 | 0.43877793 |
| 107 | PAK2 | 0.43191643 |
| 108 | GRK5 | 0.42998783 |
| 109 | NTRK1 | 0.42964282 |
| 110 | UHMK1 | 0.41688014 |
| 111 | DYRK1B | 0.41528450 |
| 112 | CAMK2G | 0.39548534 |
| 113 | MAP3K4 | 0.39214674 |
| 114 | CHEK1 | 0.38405670 |
| 115 | PRKCG | 0.37880090 |
| 116 | RPS6KA5 | 0.37115417 |
| 117 | DDR2 | 0.37065224 |
| 118 | CHEK2 | 0.36676138 |
| 119 | CDK14 | 0.35532923 |
| 120 | MAP2K1 | 0.34158791 |
| 121 | KSR2 | 0.33066998 |
| 122 | PTK2B | 0.32449659 |
| 123 | MST1R | 0.32360200 |
| 124 | STK39 | 0.31726013 |
| 125 | CDK9 | 0.31036772 |
| 126 | CSNK1E | 0.30930735 |
| 127 | FER | 0.30819578 |
| 128 | ERBB4 | 0.29364474 |
| 129 | CAMK2D | 0.27584984 |
| 130 | CDK11A | 0.27093711 |
| 131 | STK3 | 0.26829945 |
| 132 | MAPK11 | 0.25147068 |
| 133 | AKT2 | 0.25130764 |
| 134 | CDK15 | 0.24778446 |
| 135 | MUSK | 0.24220880 |
| 136 | CDK18 | 0.23066575 |
| 137 | MTOR | 0.22300610 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.15665136 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.79373338 |
| 3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.26814691 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.98489639 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.88727478 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.87316201 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.83211950 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.34229136 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.31268757 |
| 10 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.21048993 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.15672142 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.13134204 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.09773654 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.06764146 |
| 15 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.98386537 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.92468350 |
| 17 | Carbon metabolism_Homo sapiens_hsa01200 | 1.84693688 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.82793165 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.80793975 |
| 20 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.76885234 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.72494516 |
| 22 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.71527670 |
| 23 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.71191085 |
| 24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.68708558 |
| 25 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.65707112 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.63229622 |
| 27 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.61659891 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.57834734 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.51448167 |
| 30 | Base excision repair_Homo sapiens_hsa03410 | 1.49364608 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.47589047 |
| 32 | Homologous recombination_Homo sapiens_hsa03440 | 1.45433051 |
| 33 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.37475291 |
| 34 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.36949948 |
| 35 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.31741570 |
| 36 | Cell cycle_Homo sapiens_hsa04110 | 1.25447414 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.22468472 |
| 38 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.16348304 |
| 39 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.15235447 |
| 40 | Sulfur relay system_Homo sapiens_hsa04122 | 1.14719664 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.14280766 |
| 42 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.07795376 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.06557404 |
| 44 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.03040287 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.00816575 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.00807493 |
| 47 | Purine metabolism_Homo sapiens_hsa00230 | 0.99246241 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.96917011 |
| 49 | RNA degradation_Homo sapiens_hsa03018 | 0.94248058 |
| 50 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.93317770 |
| 51 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.88739966 |
| 52 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.87818020 |
| 53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.87052023 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.86673847 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.85958349 |
| 56 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.83912385 |
| 57 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.83882266 |
| 58 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.83204734 |
| 59 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.79386578 |
| 60 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.79327480 |
| 61 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.76406509 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75557662 |
| 63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.74265145 |
| 64 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.72488859 |
| 65 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.71071970 |
| 66 | Basal transcription factors_Homo sapiens_hsa03022 | 0.70547233 |
| 67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67025896 |
| 68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.64460765 |
| 69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.63492933 |
| 70 | Peroxisome_Homo sapiens_hsa04146 | 0.62732863 |
| 71 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.62179590 |
| 72 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56706005 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.55877416 |
| 74 | Alcoholism_Homo sapiens_hsa05034 | 0.53252456 |
| 75 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.53133320 |
| 76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.50034437 |
| 77 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46017616 |
| 78 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.44905214 |
| 79 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.44593956 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44531547 |
| 81 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.43055088 |
| 82 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42041541 |
| 83 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.41980480 |
| 84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41519564 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.39513816 |
| 86 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.38922985 |
| 87 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38392384 |
| 88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.38100416 |
| 89 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.37985033 |
| 90 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.36360859 |
| 91 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.35891484 |
| 92 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.35848226 |
| 93 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.35233711 |
| 94 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.32784907 |
| 95 | Bladder cancer_Homo sapiens_hsa05219 | 0.31741389 |
| 96 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.31395540 |
| 97 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30254311 |
| 98 | Thyroid cancer_Homo sapiens_hsa05216 | 0.30058433 |
| 99 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.29271039 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26604038 |
| 101 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26177149 |
| 102 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.25140851 |
| 103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.24186662 |
| 104 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.22776720 |
| 105 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21570080 |
| 106 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.21359558 |
| 107 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.19860484 |
| 108 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.18831917 |
| 109 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.18680431 |
| 110 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.18154533 |
| 111 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.17529983 |
| 112 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.16784261 |
| 113 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.16704893 |
| 114 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.11600039 |

