SWSAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.88688770
2behavioral response to nicotine (GO:0035095)5.88353082
3COPI coating of Golgi vesicle (GO:0048205)4.64688211
4Golgi transport vesicle coating (GO:0048200)4.64688211
5pteridine-containing compound biosynthetic process (GO:0042559)4.46521066
6DNA unwinding involved in DNA replication (GO:0006268)4.35903550
7protein complex biogenesis (GO:0070271)4.29200829
8respiratory chain complex IV assembly (GO:0008535)4.28013170
9cytochrome complex assembly (GO:0017004)4.26837182
10water-soluble vitamin biosynthetic process (GO:0042364)4.18753638
11nucleobase biosynthetic process (GO:0046112)4.05548910
12mitochondrial respiratory chain complex assembly (GO:0033108)4.03186665
13DNA deamination (GO:0045006)4.00821445
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.96512028
15NADH dehydrogenase complex assembly (GO:0010257)3.96512028
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96512028
17drug transmembrane transport (GO:0006855)3.94537291
18nucleoside salvage (GO:0043174)3.91050239
19purine nucleobase biosynthetic process (GO:0009113)3.85480327
20tryptophan catabolic process (GO:0006569)3.82675584
21indole-containing compound catabolic process (GO:0042436)3.82675584
22indolalkylamine catabolic process (GO:0046218)3.82675584
23indolalkylamine metabolic process (GO:0006586)3.80133569
24L-fucose catabolic process (GO:0042355)3.76332290
25fucose catabolic process (GO:0019317)3.76332290
26L-fucose metabolic process (GO:0042354)3.76332290
27one-carbon metabolic process (GO:0006730)3.70979719
28peptidyl-arginine omega-N-methylation (GO:0035247)3.70894924
29DNA replication initiation (GO:0006270)3.68635915
30piRNA metabolic process (GO:0034587)3.67108059
31pseudouridine synthesis (GO:0001522)3.67039631
32iron-sulfur cluster assembly (GO:0016226)3.66655838
33metallo-sulfur cluster assembly (GO:0031163)3.66655838
34preassembly of GPI anchor in ER membrane (GO:0016254)3.63049253
35kynurenine metabolic process (GO:0070189)3.62338401
36folic acid metabolic process (GO:0046655)3.60316123
37glycine metabolic process (GO:0006544)3.57559273
38tetrahydrofolate metabolic process (GO:0046653)3.55830431
39ubiquinone biosynthetic process (GO:0006744)3.52452025
40DNA strand elongation involved in DNA replication (GO:0006271)3.50021872
41ATP synthesis coupled proton transport (GO:0015986)3.48911504
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48911504
43negative regulation of telomere maintenance (GO:0032205)3.48543526
44regulation of protein heterodimerization activity (GO:0043497)3.41562973
45pentose-phosphate shunt (GO:0006098)3.40635358
46negative regulation of telomerase activity (GO:0051974)3.36143462
47protein maturation by protein folding (GO:0022417)3.36059480
48DNA strand elongation (GO:0022616)3.35642490
49pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.34786117
50negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.33866437
51pyrimidine-containing compound salvage (GO:0008655)3.32026532
52pyrimidine nucleoside salvage (GO:0043097)3.32026532
53DNA replication checkpoint (GO:0000076)3.31783312
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.31585292
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31082398
56tryptophan metabolic process (GO:0006568)3.29660008
57regulation of mitochondrial translation (GO:0070129)3.29309729
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28795469
59ribosomal small subunit assembly (GO:0000028)3.28227957
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25432673
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25432673
62base-excision repair, AP site formation (GO:0006285)3.25133111
63mannosylation (GO:0097502)3.22653673
64translesion synthesis (GO:0019985)3.22421460
654-hydroxyproline metabolic process (GO:0019471)3.22280974
66positive regulation of nuclease activity (GO:0032075)3.22051579
67DNA replication-dependent nucleosome assembly (GO:0006335)3.22000598
68DNA replication-dependent nucleosome organization (GO:0034723)3.22000598
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19079536
70L-phenylalanine metabolic process (GO:0006558)3.19079536
71positive regulation of prostaglandin secretion (GO:0032308)3.18655872
72IMP biosynthetic process (GO:0006188)3.15763045
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15386952
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15195171
75ubiquinone metabolic process (GO:0006743)3.14650662
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14452924
77purine nucleotide salvage (GO:0032261)3.12859349
78pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.12510901
79UMP metabolic process (GO:0046049)3.12510901
80pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.12510901
81UMP biosynthetic process (GO:0006222)3.12510901
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.12469089
83DNA double-strand break processing (GO:0000729)3.12104584
84regulation of translational termination (GO:0006449)3.11852754
85mitotic metaphase plate congression (GO:0007080)3.11816762
86chaperone-mediated protein transport (GO:0072321)3.10403791
87nucleotide salvage (GO:0043173)3.09673990
88folic acid-containing compound metabolic process (GO:0006760)3.09407941
89drug transport (GO:0015893)3.09206164
90proline biosynthetic process (GO:0006561)3.09062963
91protein-cofactor linkage (GO:0018065)3.08951462
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07896299
93GPI anchor metabolic process (GO:0006505)3.05174056
94rRNA catabolic process (GO:0016075)3.04039451
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03902355
96cellular ketone body metabolic process (GO:0046950)3.03127874
97response to pheromone (GO:0019236)3.02715150
98GMP metabolic process (GO:0046037)3.02556655
99valine metabolic process (GO:0006573)2.99375079
100sulfur amino acid catabolic process (GO:0000098)2.98742948
101galactose catabolic process (GO:0019388)2.97069768
102inner cell mass cell proliferation (GO:0001833)2.96313416
103detection of light stimulus involved in sensory perception (GO:0050962)2.95657811
104detection of light stimulus involved in visual perception (GO:0050908)2.95657811
105positive regulation of fatty acid transport (GO:2000193)2.94536072
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94386299
107L-alpha-amino acid transmembrane transport (GO:1902475)2.93515227
108viral transcription (GO:0019083)2.92602314
109regulation of nuclease activity (GO:0032069)2.91723240
110serine family amino acid biosynthetic process (GO:0009070)2.91064669
111translational termination (GO:0006415)2.89447269
112axoneme assembly (GO:0035082)2.89289946
113homocysteine metabolic process (GO:0050667)2.88736654
114dopamine transport (GO:0015872)2.88414178
115pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87034004
116pteridine-containing compound metabolic process (GO:0042558)2.86059306
117protein insertion into membrane (GO:0051205)2.85524611
118platelet dense granule organization (GO:0060155)2.84251757
119cellular biogenic amine catabolic process (GO:0042402)2.82458403
120amine catabolic process (GO:0009310)2.82458403
121regulation of cilium movement (GO:0003352)2.81066288
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80926563
123protein deneddylation (GO:0000338)2.80803840
124purine-containing compound salvage (GO:0043101)2.80763730
125postreplication repair (GO:0006301)2.80309788
126negative regulation of cell size (GO:0045792)2.80069918
1272-oxoglutarate metabolic process (GO:0006103)2.79568752
128peptidyl-arginine N-methylation (GO:0035246)2.79084324
129peptidyl-arginine methylation (GO:0018216)2.79084324
130rRNA modification (GO:0000154)2.78626919
131DNA methylation involved in gamete generation (GO:0043046)2.77953668
132quinone biosynthetic process (GO:1901663)2.77815709
133formation of translation preinitiation complex (GO:0001731)2.77381168
134telomere maintenance via semi-conservative replication (GO:0032201)2.76335744
135endoplasmic reticulum unfolded protein response (GO:0030968)2.76182478
136NADPH regeneration (GO:0006740)2.75998209
137translational elongation (GO:0006414)2.75885030
138exocrine pancreas development (GO:0031017)2.75827020
139tRNA methylation (GO:0030488)2.75233105
140establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75149472
141mitochondrion transport along microtubule (GO:0047497)2.75149472
142maternal placenta development (GO:0001893)2.74793315
143GPI anchor biosynthetic process (GO:0006506)2.74349089
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74196510
145indole-containing compound metabolic process (GO:0042430)2.72980943
146positive regulation of icosanoid secretion (GO:0032305)2.72892400
147electron transport chain (GO:0022900)2.72791835
148peptidyl-proline hydroxylation (GO:0019511)2.72575032
149synaptic transmission, cholinergic (GO:0007271)2.72247531
150reciprocal meiotic recombination (GO:0007131)2.72187959
151reciprocal DNA recombination (GO:0035825)2.72187959
152tRNA processing (GO:0008033)2.70335404
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69241442
154peptidyl-histidine modification (GO:0018202)2.67793345
155ketone body metabolic process (GO:1902224)2.66838635
156transcription elongation from RNA polymerase III promoter (GO:0006385)2.66524363
157termination of RNA polymerase III transcription (GO:0006386)2.66524363
158C-terminal protein lipidation (GO:0006501)2.65649347
159negative regulation of cholesterol transport (GO:0032375)2.64014353
160negative regulation of sterol transport (GO:0032372)2.64014353
161respiratory electron transport chain (GO:0022904)2.63857454
162replication fork processing (GO:0031297)2.63060445
163pre-miRNA processing (GO:0031054)2.61885212
164translational initiation (GO:0006413)2.60977213
165protein polyglutamylation (GO:0018095)2.60364968
166glucose catabolic process (GO:0006007)2.60183444
167C-terminal protein amino acid modification (GO:0018410)2.59328220
168cellular response to unfolded protein (GO:0034620)2.58797597
169disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.58742065
170killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.58742065
171ER-nucleus signaling pathway (GO:0006984)2.57644441
172positive regulation of synapse maturation (GO:0090129)2.57536612
173SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57111873
174mitochondrial RNA metabolic process (GO:0000959)2.56970494
175pyrimidine nucleobase metabolic process (GO:0006206)2.56441068
176NAD biosynthetic process (GO:0009435)2.55977115
177lipopolysaccharide biosynthetic process (GO:0009103)2.55372939
178negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54569881
179IMP metabolic process (GO:0046040)2.54565929
180UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54552515
181intracellular protein transmembrane import (GO:0044743)2.54426821
182negative regulation of RNA splicing (GO:0033119)2.54070705
183regulation of nuclear cell cycle DNA replication (GO:0033262)2.51935044
184adaptation of signaling pathway (GO:0023058)2.50510537
185cullin deneddylation (GO:0010388)2.49560211
186proteasome assembly (GO:0043248)2.47886516
187hydrogen ion transmembrane transport (GO:1902600)2.47251033
188proton transport (GO:0015992)2.45455313
189pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44391543
190L-methionine salvage (GO:0071267)2.43206597
191L-methionine biosynthetic process (GO:0071265)2.43206597
192amino acid salvage (GO:0043102)2.43206597
193tRNA modification (GO:0006400)2.41545713
194epithelial cilium movement (GO:0003351)2.41507186
195protein localization to cilium (GO:0061512)2.41271341
196hydrogen transport (GO:0006818)2.40874409
197phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40363747
198negative regulation of mast cell activation (GO:0033004)2.39205690
199DNA demethylation (GO:0080111)2.37957854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58990915
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05522830
3ZNF274_21170338_ChIP-Seq_K562_Hela3.96573478
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.23798444
5MYC_22102868_ChIP-Seq_BL_Human3.12941941
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.00639249
7VDR_22108803_ChIP-Seq_LS180_Human2.95525362
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77144598
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.73733020
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58087062
11IGF1R_20145208_ChIP-Seq_DFB_Human2.55501951
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38330890
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37982944
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35382722
15VDR_21846776_ChIP-Seq_THP-1_Human2.16943142
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.10979289
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10144866
18EWS_26573619_Chip-Seq_HEK293_Human2.10024708
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10015804
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.09357234
21XRN2_22483619_ChIP-Seq_HELA_Human2.04244963
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01758620
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.01715230
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01365436
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01101708
26GATA1_22025678_ChIP-Seq_K562_Human1.98290889
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95621972
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92801192
29MYC_18940864_ChIP-ChIP_HL60_Human1.91012568
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90316140
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.90068373
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88458570
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.87411558
34TP53_22573176_ChIP-Seq_HFKS_Human1.84390374
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84034489
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83851711
37CIITA_25753668_ChIP-Seq_RAJI_Human1.83812973
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81938140
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80836972
40EZH2_22144423_ChIP-Seq_EOC_Human1.79671177
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77134602
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76068063
43IRF1_19129219_ChIP-ChIP_H3396_Human1.75779128
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75567475
45GBX2_23144817_ChIP-Seq_PC3_Human1.74583163
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74139533
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69660672
48FUS_26573619_Chip-Seq_HEK293_Human1.69493424
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69413242
50ZNF263_19887448_ChIP-Seq_K562_Human1.68989766
51DCP1A_22483619_ChIP-Seq_HELA_Human1.68277627
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66603502
53GABP_19822575_ChIP-Seq_HepG2_Human1.66324807
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65659036
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63250833
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60019818
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59581620
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55376234
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53385978
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52862739
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.52643319
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.51508687
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51209876
64ER_23166858_ChIP-Seq_MCF-7_Human1.49444266
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.47845379
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.47577281
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46584713
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.45792952
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45792952
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44363924
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.43906457
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42741608
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42617476
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41746238
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41736646
76AR_20517297_ChIP-Seq_VCAP_Human1.41673986
77P300_19829295_ChIP-Seq_ESCs_Human1.41575285
78VDR_23849224_ChIP-Seq_CD4+_Human1.41344781
79NCOR_22424771_ChIP-Seq_293T_Human1.41310376
80TAF15_26573619_Chip-Seq_HEK293_Human1.40157763
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40045722
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39960568
83FOXP3_21729870_ChIP-Seq_TREG_Human1.37400597
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37078773
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36716808
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.36176846
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34954031
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33401054
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32857114
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32762757
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32291658
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31826216
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31373410
94ELK1_19687146_ChIP-ChIP_HELA_Human1.31262787
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31125991
96CBP_20019798_ChIP-Seq_JUKART_Human1.30614278
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30614278
98LXR_22292898_ChIP-Seq_THP-1_Human1.30593866
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30466544
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28492809
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28226604
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27604846
103NANOG_20526341_ChIP-Seq_ESCs_Human1.27432331
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27233426
105HOXB7_26014856_ChIP-Seq_BT474_Human1.26916071
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.23729922
107SOX2_19829295_ChIP-Seq_ESCs_Human1.22971004
108NANOG_19829295_ChIP-Seq_ESCs_Human1.22971004
109ERA_21632823_ChIP-Seq_H3396_Human1.22347060
110KDM5A_27292631_Chip-Seq_BREAST_Human1.21659914
111BCAT_22108803_ChIP-Seq_LS180_Human1.20754526
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20467993
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19835941
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19259957
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18638792
116P68_20966046_ChIP-Seq_HELA_Human1.17594457
117TFEB_21752829_ChIP-Seq_HELA_Human1.17586448
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16114562
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.14738831
120UTX_26944678_Chip-Seq_JUKART_Human1.14262606
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.14175399
122FOXP1_21924763_ChIP-Seq_HESCs_Human1.13312080
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13083293
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12724858
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12639739
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12314034
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12192951
128TCF7_22412390_ChIP-Seq_EML_Mouse1.11867603
129REST_21632747_ChIP-Seq_MESCs_Mouse1.11719868
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11204454
131TTF2_22483619_ChIP-Seq_HELA_Human1.10914076
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10381192
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10050592
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09240430
135MYC_19829295_ChIP-Seq_ESCs_Human1.08777746
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08551181
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08054592
138RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07897498
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07870451
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07570745
141GATA3_26560356_Chip-Seq_TH2_Human1.07370930
142KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06966487
143RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06749752
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06037921
145TAF2_19829295_ChIP-Seq_ESCs_Human1.05790082
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05679110
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05606393
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05416963
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05363560
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05140471
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04077606
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03118390
153P53_21459846_ChIP-Seq_SAOS-2_Human1.02974812
154PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01584633
155PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01403778
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00947551
157ELF1_20517297_ChIP-Seq_JURKAT_Human1.00942090
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00645027
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00467019
160FOXH1_21741376_ChIP-Seq_EPCs_Human1.00126731
161CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00072962
162AR_21909140_ChIP-Seq_LNCAP_Human0.99984378
163KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99277064
164ELK3_25401928_ChIP-Seq_HUVEC_Human0.99263377
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99211096
166ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98762213
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97483709
168KDM2B_26808549_Chip-Seq_DND41_Human0.96577399
169AR_25329375_ChIP-Seq_VCAP_Human0.96362878
170OCT4_20526341_ChIP-Seq_ESCs_Human0.96027378
171FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95236879
172POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93961741
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93961741
174HTT_18923047_ChIP-ChIP_STHdh_Human0.93790696
175TCF4_22108803_ChIP-Seq_LS180_Human0.93110249
176TCF4_23295773_ChIP-Seq_U87_Human0.92374893
177SALL1_21062744_ChIP-ChIP_HESCs_Human0.90004992
178TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88731590
179RNF2_27304074_Chip-Seq_NSC_Mouse0.87831009
180NFE2_27457419_Chip-Seq_LIVER_Mouse0.87687056
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85434620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.31809739
2MP0005360_urolithiasis4.05410207
3MP0003693_abnormal_embryo_hatching3.76845113
4MP0002139_abnormal_hepatobiliary_system3.17292645
5MP0005365_abnormal_bile_salt3.12449565
6MP0003195_calcinosis2.74692841
7MP0008877_abnormal_DNA_methylation2.61168615
8MP0005085_abnormal_gallbladder_physiolo2.57908387
9MP0005551_abnormal_eye_electrophysiolog2.47469283
10MP0003806_abnormal_nucleotide_metabolis2.46574018
11MP0006292_abnormal_olfactory_placode2.41076803
12MP0001968_abnormal_touch/_nociception2.36400608
13MP0004957_abnormal_blastocyst_morpholog2.28066720
14MP0002909_abnormal_adrenal_gland2.27225546
15MP0003123_paternal_imprinting2.24921574
16MP0009840_abnormal_foam_cell2.24542557
17MP0008961_abnormal_basal_metabolism2.20353025
18MP0005220_abnormal_exocrine_pancreas2.19825709
19MP0001986_abnormal_taste_sensitivity2.18535990
20MP0002102_abnormal_ear_morphology2.13798009
21MP0008058_abnormal_DNA_repair2.09486209
22MP0003011_delayed_dark_adaptation2.04267073
23MP0003111_abnormal_nucleus_morphology2.03637500
24MP0004147_increased_porphyrin_level1.96071713
25MP0002736_abnormal_nociception_after1.90722722
26MP0008872_abnormal_physiological_respon1.90270304
27MP0001944_abnormal_pancreas_morphology1.89579353
28MP0009697_abnormal_copulation1.89521769
29MP0005646_abnormal_pituitary_gland1.85242208
30MP0002837_dystrophic_cardiac_calcinosis1.77421544
31MP0005083_abnormal_biliary_tract1.77284326
32MP0001666_abnormal_nutrient_absorption1.76650895
33MP0005253_abnormal_eye_physiology1.74227884
34MP0001730_embryonic_growth_arrest1.73971849
35MP0004142_abnormal_muscle_tone1.73346754
36MP0000372_irregular_coat_pigmentation1.71678350
37MP0005645_abnormal_hypothalamus_physiol1.71381827
38MP0003656_abnormal_erythrocyte_physiolo1.69183083
39MP0009672_abnormal_birth_weight1.69039295
40MP0005332_abnormal_amino_acid1.66433573
41MP0008875_abnormal_xenobiotic_pharmacok1.64467060
42MP0003787_abnormal_imprinting1.63600954
43MP0002138_abnormal_hepatobiliary_system1.63108224
44MP0003646_muscle_fatigue1.61427343
45MP0010094_abnormal_chromosome_stability1.60742135
46MP0002928_abnormal_bile_duct1.59611549
47MP0002876_abnormal_thyroid_physiology1.55089283
48MP0009745_abnormal_behavioral_response1.52796328
49MP0002693_abnormal_pancreas_physiology1.51611622
50MP0000609_abnormal_liver_physiology1.48879034
51MP0001905_abnormal_dopamine_level1.48314197
52MP0009643_abnormal_urine_homeostasis1.48094813
53MP0004043_abnormal_pH_regulation1.46742445
54MP0010386_abnormal_urinary_bladder1.45357777
55MP0001485_abnormal_pinna_reflex1.44729317
56MP0002163_abnormal_gland_morphology1.43427950
57MP0004742_abnormal_vestibular_system1.42393260
58MP0005671_abnormal_response_to1.42228415
59MP0006036_abnormal_mitochondrial_physio1.42218640
60MP0002160_abnormal_reproductive_system1.41799589
61MP0004885_abnormal_endolymph1.41671194
62MP0005389_reproductive_system_phenotype1.41171817
63MP0000678_abnormal_parathyroid_gland1.40758311
64MP0009046_muscle_twitch1.40422652
65MP0010307_abnormal_tumor_latency1.39898082
66MP0000631_abnormal_neuroendocrine_gland1.39480347
67MP0003077_abnormal_cell_cycle1.39227858
68MP0006276_abnormal_autonomic_nervous1.38453848
69MP0003880_abnormal_central_pattern1.37757263
70MP0004145_abnormal_muscle_electrophysio1.37694498
71MP0002234_abnormal_pharynx_morphology1.36628022
72MP0001529_abnormal_vocalization1.36512756
73MP0010352_gastrointestinal_tract_polyps1.35844805
74MP0005174_abnormal_tail_pigmentation1.35835180
75MP0002080_prenatal_lethality1.33849268
76MP0001764_abnormal_homeostasis1.31580282
77MP0003252_abnormal_bile_duct1.31464811
78MP0006072_abnormal_retinal_apoptosis1.30264514
79MP0002396_abnormal_hematopoietic_system1.29727662
80MP0002272_abnormal_nervous_system1.27736207
81MP0003868_abnormal_feces_composition1.27178401
82MP0004133_heterotaxia1.27033543
83MP0002938_white_spotting1.27002814
84MP0002078_abnormal_glucose_homeostasis1.26464203
85MP0005319_abnormal_enzyme/_coenzyme1.26224358
86MP0000350_abnormal_cell_proliferation1.24957780
87MP0002735_abnormal_chemical_nociception1.23674194
88MP0003119_abnormal_digestive_system1.23383099
89MP0004019_abnormal_vitamin_homeostasis1.22554362
90MP0003705_abnormal_hypodermis_morpholog1.21364136
91MP0003136_yellow_coat_color1.20366613
92MP0005075_abnormal_melanosome_morpholog1.20051983
93MP0001984_abnormal_olfaction1.20009523
94MP0008007_abnormal_cellular_replicative1.18246144
95MP0003191_abnormal_cellular_cholesterol1.17936838
96MP0001919_abnormal_reproductive_system1.16228792
97MP0005410_abnormal_fertilization1.15495388
98MP0001188_hyperpigmentation1.14428402
99MP0000598_abnormal_liver_morphology1.11696665
100MP0003786_premature_aging1.11635582
101MP0005636_abnormal_mineral_homeostasis1.11057734
102MP0004185_abnormal_adipocyte_glucose1.10795389
103MP0009053_abnormal_anal_canal1.09902779
104MP0002653_abnormal_ependyma_morphology1.09111215
105MP0000427_abnormal_hair_cycle1.07540650
106MP0000358_abnormal_cell_content/1.05686929
107MP0002084_abnormal_developmental_patter1.04587984
108MP0005379_endocrine/exocrine_gland_phen1.03905040
109MP0001970_abnormal_pain_threshold1.02470295
110MP0000490_abnormal_crypts_of1.01903441
111MP0002733_abnormal_thermal_nociception1.01640246
112MP0002089_abnormal_postnatal_growth/wei1.01023238
113MP0002572_abnormal_emotion/affect_behav1.00871358
114MP0006035_abnormal_mitochondrial_morpho1.00700361
115MP0004808_abnormal_hematopoietic_stem0.99600826
116MP0001501_abnormal_sleep_pattern0.99388184
117MP0002638_abnormal_pupillary_reflex0.99327367
118MP0002085_abnormal_embryonic_tissue0.99159177
119MP0001697_abnormal_embryo_size0.98979583
120MP0008995_early_reproductive_senescence0.98339925
121MP0001672_abnormal_embryogenesis/_devel0.97840763
122MP0005380_embryogenesis_phenotype0.97840763
123MP0001765_abnormal_ion_homeostasis0.97134513
124MP0008789_abnormal_olfactory_epithelium0.96065294
125MP0009764_decreased_sensitivity_to0.95056600
126MP0003890_abnormal_embryonic-extraembry0.94353816
127MP0005195_abnormal_posterior_eye0.92701661
128MP0005670_abnormal_white_adipose0.92362825
129MP0002019_abnormal_tumor_incidence0.92358606
130MP0003698_abnormal_male_reproductive0.92116467
131MP0002095_abnormal_skin_pigmentation0.92015313
132MP0000230_abnormal_systemic_arterial0.91957369
133MP0000465_gastrointestinal_hemorrhage0.91905910
134MP0001929_abnormal_gametogenesis0.90824704
135MP0000313_abnormal_cell_death0.90415282
136MP0004197_abnormal_fetal_growth/weight/0.89791385
137MP0009333_abnormal_splenocyte_physiolog0.89205236
138MP0003137_abnormal_impulse_conducting0.89116720
139MP0002557_abnormal_social/conspecific_i0.89108461
140MP0002088_abnormal_embryonic_growth/wei0.88855048
141MP0003303_peritoneal_inflammation0.88790755
142MP0010329_abnormal_lipoprotein_level0.88168727
143MP0002210_abnormal_sex_determination0.87611327
144MP0005386_behavior/neurological_phenoty0.87319361
145MP0004924_abnormal_behavior0.87319361
146MP0005058_abnormal_lysosome_morphology0.87104426
147MP0001545_abnormal_hematopoietic_system0.86814905
148MP0005397_hematopoietic_system_phenotyp0.86814905
149MP0002877_abnormal_melanocyte_morpholog0.86801279
150MP0003984_embryonic_growth_retardation0.85990251
151MP0008775_abnormal_heart_ventricle0.85734240
152MP0001963_abnormal_hearing_physiology0.84916304
153MP0002086_abnormal_extraembryonic_tissu0.84531218
154MP0005084_abnormal_gallbladder_morpholo0.84158053
155MP0002398_abnormal_bone_marrow0.82732493
156MP0001486_abnormal_startle_reflex0.82714625
157MP0006054_spinal_hemorrhage0.82533534
158MP0005423_abnormal_somatic_nervous0.82408233
159MP0009379_abnormal_foot_pigmentation0.82271479
160MP0008770_decreased_survivor_rate0.82243896
161MP0002118_abnormal_lipid_homeostasis0.81947181
162MP0002277_abnormal_respiratory_mucosa0.81705232
163MP0002148_abnormal_hypersensitivity_rea0.81442268
164MP0003186_abnormal_redox_activity0.81132524
165MP0002064_seizures0.80634113
166MP0003763_abnormal_thymus_physiology0.80632269
167MP0005666_abnormal_adipose_tissue0.80186942
168MP0002970_abnormal_white_adipose0.80145772
169MP0009703_decreased_birth_body0.78448106
170MP0003718_maternal_effect0.78429067
171MP0004859_abnormal_synaptic_plasticity0.77497066
172MP0001873_stomach_inflammation0.76492494
173MP0001661_extended_life_span0.76482078
174MP0005167_abnormal_blood-brain_barrier0.76117353
175MP0004130_abnormal_muscle_cell0.75824688
176MP0000703_abnormal_thymus_morphology0.75238077
177MP0000747_muscle_weakness0.74013038
178MP0000689_abnormal_spleen_morphology0.73900029
179MP0001756_abnormal_urination0.73616224
180MP0003172_abnormal_lysosome_physiology0.72965614
181MP0002722_abnormal_immune_system0.72924006

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.92543614
2Intrahepatic cholestasis (HP:0001406)3.89425618
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75268854
4Abnormality of midbrain morphology (HP:0002418)3.65013718
5Molar tooth sign on MRI (HP:0002419)3.65013718
6Hyperglycinemia (HP:0002154)3.57008222
7Hypoglycemic coma (HP:0001325)3.54511715
8Pancreatic fibrosis (HP:0100732)3.48497117
9True hermaphroditism (HP:0010459)3.46467169
10Reduced antithrombin III activity (HP:0001976)3.37326293
11Nephronophthisis (HP:0000090)3.29461866
12Late onset (HP:0003584)3.21532191
13Deep palmar crease (HP:0006191)3.15763942
14Mitochondrial inheritance (HP:0001427)3.14493283
15Acute necrotizing encephalopathy (HP:0006965)3.09827715
16Increased CSF lactate (HP:0002490)3.06705397
17Attenuation of retinal blood vessels (HP:0007843)2.97536283
18Ketosis (HP:0001946)2.94607577
19Delayed CNS myelination (HP:0002188)2.94006357
20Abnormal protein glycosylation (HP:0012346)2.91717496
21Abnormal glycosylation (HP:0012345)2.91717496
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91717496
23Abnormal protein N-linked glycosylation (HP:0012347)2.91717496
24Ketoacidosis (HP:0001993)2.90033987
25Abnormality of alanine metabolism (HP:0010916)2.88319492
26Hyperalaninemia (HP:0003348)2.88319492
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88319492
28Hepatocellular necrosis (HP:0001404)2.86004070
29Bony spicule pigmentary retinopathy (HP:0007737)2.85508766
30Type II lissencephaly (HP:0007260)2.84448706
31Acute encephalopathy (HP:0006846)2.83218833
32Medial flaring of the eyebrow (HP:0010747)2.77114346
33Abnormal mitochondria in muscle tissue (HP:0008316)2.77087967
34Hypoglycemic seizures (HP:0002173)2.76916130
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76336942
36Abolished electroretinogram (ERG) (HP:0000550)2.73751473
37Progressive macrocephaly (HP:0004481)2.69440296
38Birth length less than 3rd percentile (HP:0003561)2.69426032
39Abnormality of the renal medulla (HP:0100957)2.67342818
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64862777
413-Methylglutaconic aciduria (HP:0003535)2.63150454
42Lipid accumulation in hepatocytes (HP:0006561)2.62294457
43Hyperglycinuria (HP:0003108)2.61945200
44Acute lymphatic leukemia (HP:0006721)2.61638607
45Hyperinsulinemic hypoglycemia (HP:0000825)2.58760732
46Spastic diplegia (HP:0001264)2.57801212
47Hyperammonemia (HP:0001987)2.57604942
48Abnormality of glycine metabolism (HP:0010895)2.56969404
49Abnormality of serine family amino acid metabolism (HP:0010894)2.56969404
50Gout (HP:0001997)2.55249564
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55010597
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53242915
53Abnormality of the pancreatic islet cells (HP:0006476)2.51967595
54Abnormality of endocrine pancreas physiology (HP:0012093)2.51967595
55Abnormality of the renal cortex (HP:0011035)2.50150667
56Fibular aplasia (HP:0002990)2.47655851
57Cystic liver disease (HP:0006706)2.45566313
58Ependymoma (HP:0002888)2.44602291
59Increased hepatocellular lipid droplets (HP:0006565)2.44470681
60Colon cancer (HP:0003003)2.43819774
61Insulin resistance (HP:0000855)2.42615770
62Bile duct proliferation (HP:0001408)2.41807220
63Abnormal biliary tract physiology (HP:0012439)2.41807220
64Abnormality of the intrinsic pathway (HP:0010989)2.38556086
65Increased serum lactate (HP:0002151)2.36781670
66Hypothermia (HP:0002045)2.31865497
67Facial hemangioma (HP:0000329)2.31396081
68Hyperacusis (HP:0010780)2.29372900
69Decreased circulating renin level (HP:0003351)2.28991429
70Sclerocornea (HP:0000647)2.28319932
71Hypoplasia of the fovea (HP:0007750)2.27062177
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.27062177
73Decreased central vision (HP:0007663)2.26046993
74Abnormal rod and cone electroretinograms (HP:0008323)2.25592740
75Type I transferrin isoform profile (HP:0003642)2.24038081
76Methylmalonic acidemia (HP:0002912)2.22326165
77Chronic hepatic failure (HP:0100626)2.22308739
78Optic disc pallor (HP:0000543)2.22105510
79Deep venous thrombosis (HP:0002625)2.20327163
80Neonatal onset (HP:0003623)2.19346662
81Methylmalonic aciduria (HP:0012120)2.18524816
82Pendular nystagmus (HP:0012043)2.18452280
83Congenital stationary night blindness (HP:0007642)2.16473325
84IgM deficiency (HP:0002850)2.15738726
85Overlapping toe (HP:0001845)2.15093823
86Lactic acidosis (HP:0003128)2.14544502
87Bilateral microphthalmos (HP:0007633)2.14511684
88Limb hypertonia (HP:0002509)2.14164982
89Posterior subcapsular cataract (HP:0007787)2.13885452
90Aplasia/hypoplasia of the uterus (HP:0008684)2.13633764
91Abnormal drinking behavior (HP:0030082)2.10522704
92Polydipsia (HP:0001959)2.10522704
93Capillary hemangiomas (HP:0005306)2.10433626
94Gait imbalance (HP:0002141)2.09659250
95Type II diabetes mellitus (HP:0005978)2.09577975
96Symptomatic seizures (HP:0011145)2.09278579
97Concave nail (HP:0001598)2.08829573
98Renal Fanconi syndrome (HP:0001994)2.08812022
99Congenital primary aphakia (HP:0007707)2.07415037
100Ragged-red muscle fibers (HP:0003200)2.05197321
101Inability to walk (HP:0002540)2.04687002
102Hyperbilirubinemia (HP:0002904)2.04546396
103Fatigue (HP:0012378)2.03886288
104Abnormality of fatty-acid metabolism (HP:0004359)2.03859465
105Abnormality of the lower motor neuron (HP:0002366)2.03387398
106Partial agenesis of the corpus callosum (HP:0001338)2.02883357
107Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01731981
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01731981
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01674745
110Tubular atrophy (HP:0000092)2.00612343
111Dicarboxylic aciduria (HP:0003215)2.00163071
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00163071
113Cerebellar dysplasia (HP:0007033)1.99657038
114Lethargy (HP:0001254)1.98285708
115Hypoplasia of the uterus (HP:0000013)1.98106712
116Renal cortical cysts (HP:0000803)1.97083492
117Cortical dysplasia (HP:0002539)1.96992441
118Status epilepticus (HP:0002133)1.96983108
119Hyperglycemia (HP:0003074)1.96320107
120Insomnia (HP:0100785)1.95100833
121Abnormality of the fovea (HP:0000493)1.93993084
122Absent thumb (HP:0009777)1.93753813
123Congenital, generalized hypertrichosis (HP:0004540)1.93628841
124Agitation (HP:0000713)1.93605866
125Reticulocytopenia (HP:0001896)1.93119488
126Abnormality of cells of the erythroid lineage (HP:0012130)1.93024508
127Abnormality of purine metabolism (HP:0004352)1.92734336
128Nephrogenic diabetes insipidus (HP:0009806)1.91962288
129Stomach cancer (HP:0012126)1.91560564
130Anencephaly (HP:0002323)1.91333863
131Exertional dyspnea (HP:0002875)1.90598031
132Constricted visual fields (HP:0001133)1.89659943
133Pancreatic islet-cell hyperplasia (HP:0004510)1.89388050
134Congenital hepatic fibrosis (HP:0002612)1.88744207
135Multiple enchondromatosis (HP:0005701)1.88395808
136Sensorimotor neuropathy (HP:0007141)1.88297222
137Cerebral edema (HP:0002181)1.88007385
138Abnormal number of erythroid precursors (HP:0012131)1.86291875
139Fat malabsorption (HP:0002630)1.86060022
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.85231993
141Hypoplasia of the pons (HP:0012110)1.84980339
142Elfin facies (HP:0004428)1.84431861
143Male pseudohermaphroditism (HP:0000037)1.84270131
144Abnormality of nucleobase metabolism (HP:0010932)1.84155243
145Progressive muscle weakness (HP:0003323)1.83921603
146Rhabdomyolysis (HP:0003201)1.83550006
147Decreased subcutaneous fat (HP:0001002)1.82967999
148Abnormality of polysaccharide metabolism (HP:0011012)1.81653443
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81653443
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81653443
151Muscular hypotonia of the trunk (HP:0008936)1.81081991
152Cutaneous melanoma (HP:0012056)1.80958120
153Polyuria (HP:0000103)1.80577939
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.80152421
155Retinal atrophy (HP:0001105)1.80069957
156Progressive inability to walk (HP:0002505)1.79815204
157Urinary glycosaminoglycan excretion (HP:0003541)1.79613578
158Mucopolysacchariduria (HP:0008155)1.79613578
159Lissencephaly (HP:0001339)1.79143459
160Progressive microcephaly (HP:0000253)1.78824575
161Abnormality of the pons (HP:0007361)1.77917346
162Respiratory failure (HP:0002878)1.77706116
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77123534
164Polygenic inheritance (HP:0010982)1.76638748
165Emotional lability (HP:0000712)1.75467861
166Abnormal neuron morphology (HP:0012757)1.75135803
167Abnormality of the motor neurons (HP:0002450)1.75135803
168Gastrointestinal stroma tumor (HP:0100723)1.73455347
169Visual hallucinations (HP:0002367)1.72897105
170Hepatic necrosis (HP:0002605)1.72527743
171Abnormality of subcutaneous fat tissue (HP:0001001)1.71609034
172Slender long bone (HP:0003100)1.67506207
173Basal cell carcinoma (HP:0002671)1.67017716
174Abnormality of pyrimidine metabolism (HP:0004353)1.66997057
175Microretrognathia (HP:0000308)1.65722995
176Generalized hypotonia (HP:0001290)1.62871991
177Abnormal number of incisors (HP:0011064)1.62338720
178Self-mutilation (HP:0000742)1.62281430
179Metabolic acidosis (HP:0001942)1.62003855
180Impulsivity (HP:0100710)1.61312563
181Abnormality of sulfur amino acid metabolism (HP:0004339)1.60815582
182Central scotoma (HP:0000603)1.60378890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT35.33732996
2FRK4.62398234
3TRIB34.07961789
4PKN23.73199558
5ZAK3.73036861
6EEF2K3.29101913
7VRK23.17390052
8ADRBK23.09109591
9NUAK13.01356882
10BMPR1B2.83635328
11MAP4K22.68736291
12GRK12.53873989
13STK242.35571143
14STK162.29116178
15DYRK32.27711919
16CDC72.27311591
17WNK32.26300248
18ERN12.21724612
19WNK41.88998898
20LRRK21.86761761
21TXK1.82631962
22BCKDK1.81761405
23PINK11.79010126
24PASK1.78956996
25NEK11.71502779
26SCYL21.67348912
27CDK121.65757897
28TIE11.64266532
29NME21.62652491
30KSR21.57132977
31INSRR1.56854628
32DYRK21.53576036
33ACVR1B1.51983831
34ARAF1.49416256
35BRAF1.47303160
36NEK21.46946870
37TRIM281.43748279
38TESK21.42487770
39PIM21.42446425
40MAPK131.42295906
41PDGFRA1.38904757
42OXSR11.36917583
43CASK1.36725670
44TAF11.33296565
45PRKD21.29918680
46CAMKK21.29460044
47RPS6KB21.24195040
48TTK1.23605868
49VRK11.21784712
50WEE11.20784860
51ZAP701.19648485
52KIT1.19488810
53BRD41.18435914
54RAF11.17739092
55MAP2K21.16921470
56STK38L1.15129368
57MAP3K101.10094792
58EIF2AK31.09933860
59TAOK31.09384124
60BUB11.09364423
61MAPK111.05147958
62CSNK1G31.04923487
63MAP3K21.01233413
64TLK11.00923994
65PTK60.99822239
66STK390.99328813
67TNIK0.97654509
68ADRBK10.97390764
69PLK30.97090776
70CDK40.92984203
71IKBKB0.92511311
72PAK60.92329803
73MAP3K40.91139400
74CSNK1G20.91070122
75MAP3K80.90397398
76TEC0.89044649
77CSNK1G10.88047981
78PIM10.86108166
79KSR10.85963346
80TGFBR10.85265305
81BRSK20.84744571
82TAOK10.84728823
83ATR0.84717143
84ALK0.84670897
85CDK70.82636870
86MST40.81074500
87ITK0.80500797
88DAPK20.80438729
89PRKCG0.80379457
90BRSK10.80349184
91PIK3CA0.80345083
92PLK10.80012342
93GRK50.79547282
94CSNK1A1L0.77833466
95MKNK20.77392132
96MAP2K60.76274118
97SIK10.75283558
98CSF1R0.74984098
99MAP2K70.74913368
100MAP3K50.74391090
101MAPKAPK30.74350604
102MAPKAPK50.74225830
103FES0.73662746
104PRKD30.72915163
105RET0.72613174
106KDR0.72481692
107PRKCE0.72405226
108MAP3K90.72124869
109PHKG20.71157187
110PHKG10.71157187
111MUSK0.71124756
112CAMKK10.69782416
113AURKA0.69673633
114PRKCQ0.68256660
115PLK40.68223494
116MAP4K10.67888198
117RPS6KA40.67680390
118EIF2AK10.67161280
119MAPK150.66991491
120NME10.65594865
121SYK0.65250481
122STK100.63047889
123STK30.62565462
124GRK60.62345803
125RPS6KA50.61036658
126MTOR0.60805700
127CHEK20.59940534
128MAP3K110.57826596
129PRKG20.55504750
130PKN10.53667742
131GRK70.51444571
132PRKCI0.51127396
133EIF2AK20.50983182
134PAK40.50087863
135AKT20.49095282
136DAPK10.47492305
137TESK10.46309467
138TNK20.46158726
139CCNB10.46081228
140CSNK1A10.44715232
141DYRK1B0.44105767
142PAK20.43475438
143ERBB30.43107621
144BTK0.42695849
145ICK0.41662485
146PLK20.41480690
147PRKAA10.40037539
148JAK30.40032531
149TRPM70.39678440
150LATS10.39109722
151LIMK10.39005608
152LYN0.38885755
153RPS6KA20.38838323
154PRKACA0.38312002
155PTK20.38035900
156PAK30.37452415
157FGFR20.37204564
158CDK190.36174847
159UHMK10.35914758
160CAMK2A0.35841470
161PRKCA0.35708658
162CSNK2A20.34905199
163TAOK20.34617242
164BLK0.34101475
165CSNK2A10.33469854
166JAK20.32633131
167CDK20.32540742
168CAMK10.32357756
169STK110.32013329
170PRKG10.29131012
171CHUK0.27958684
172LCK0.26691358

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007903.31291459
2DNA replication_Homo sapiens_hsa030303.13975215
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.09165285
4Caffeine metabolism_Homo sapiens_hsa002323.08123269
5Oxidative phosphorylation_Homo sapiens_hsa001903.08092601
6One carbon pool by folate_Homo sapiens_hsa006702.77353200
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68155001
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.64040924
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51632128
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50045742
11Selenocompound metabolism_Homo sapiens_hsa004502.46613625
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45478636
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44907720
14Parkinsons disease_Homo sapiens_hsa050122.42220079
15Sulfur relay system_Homo sapiens_hsa041222.30002520
16Linoleic acid metabolism_Homo sapiens_hsa005912.13912021
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11152427
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01996025
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95948735
20Biosynthesis of amino acids_Homo sapiens_hsa012301.94531847
21Pyrimidine metabolism_Homo sapiens_hsa002401.92283811
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86822462
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.82731736
24Mismatch repair_Homo sapiens_hsa034301.81131827
25Nitrogen metabolism_Homo sapiens_hsa009101.75776941
26Pentose phosphate pathway_Homo sapiens_hsa000301.74469137
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70190277
28Fanconi anemia pathway_Homo sapiens_hsa034601.69875008
29Arginine biosynthesis_Homo sapiens_hsa002201.68737086
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68396412
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.68199361
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64087753
33Huntingtons disease_Homo sapiens_hsa050161.62181509
34Ribosome_Homo sapiens_hsa030101.61835104
35Spliceosome_Homo sapiens_hsa030401.60462850
36Carbon metabolism_Homo sapiens_hsa012001.57922158
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56514326
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.54420438
39Propanoate metabolism_Homo sapiens_hsa006401.54194276
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49770503
41Alzheimers disease_Homo sapiens_hsa050101.48669741
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.46706250
43Ether lipid metabolism_Homo sapiens_hsa005651.46225683
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43905619
45RNA polymerase_Homo sapiens_hsa030201.41414312
46Primary immunodeficiency_Homo sapiens_hsa053401.41013963
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40416945
48Basal transcription factors_Homo sapiens_hsa030221.39707622
49Nicotine addiction_Homo sapiens_hsa050331.37452738
50N-Glycan biosynthesis_Homo sapiens_hsa005101.35209101
51RNA transport_Homo sapiens_hsa030131.33690862
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33198491
53Fatty acid degradation_Homo sapiens_hsa000711.32161933
54Sulfur metabolism_Homo sapiens_hsa009201.27411924
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27008946
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26463071
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22662576
58Cardiac muscle contraction_Homo sapiens_hsa042601.22016312
59Cell cycle_Homo sapiens_hsa041101.20006273
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20004272
61Chemical carcinogenesis_Homo sapiens_hsa052041.15364545
62Arachidonic acid metabolism_Homo sapiens_hsa005901.15146437
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14376042
64Asthma_Homo sapiens_hsa053101.13575988
65Base excision repair_Homo sapiens_hsa034101.11738302
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03235329
67Fat digestion and absorption_Homo sapiens_hsa049751.02691666
68Central carbon metabolism in cancer_Homo sapiens_hsa052301.02342105
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.99690360
70Nucleotide excision repair_Homo sapiens_hsa034200.98551558
71Tryptophan metabolism_Homo sapiens_hsa003800.98198959
72Lysine degradation_Homo sapiens_hsa003100.97880349
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97020862
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96828389
75Galactose metabolism_Homo sapiens_hsa000520.94200152
76Phototransduction_Homo sapiens_hsa047440.94050647
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92172779
78Pyruvate metabolism_Homo sapiens_hsa006200.92038266
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90909078
80Protein export_Homo sapiens_hsa030600.89148140
81Graft-versus-host disease_Homo sapiens_hsa053320.86153422
82Purine metabolism_Homo sapiens_hsa002300.86053766
83Retinol metabolism_Homo sapiens_hsa008300.84599124
84Collecting duct acid secretion_Homo sapiens_hsa049660.84349853
85Taste transduction_Homo sapiens_hsa047420.82994852
86Regulation of autophagy_Homo sapiens_hsa041400.82579357
87AMPK signaling pathway_Homo sapiens_hsa041520.82088596
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81195782
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80375514
90Morphine addiction_Homo sapiens_hsa050320.80084937
91Systemic lupus erythematosus_Homo sapiens_hsa053220.79899598
92Alcoholism_Homo sapiens_hsa050340.78769291
93Homologous recombination_Homo sapiens_hsa034400.78481881
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78093543
95Type I diabetes mellitus_Homo sapiens_hsa049400.76896556
96Bladder cancer_Homo sapiens_hsa052190.76832543
97Allograft rejection_Homo sapiens_hsa053300.75456828
98mTOR signaling pathway_Homo sapiens_hsa041500.74829305
99Insulin secretion_Homo sapiens_hsa049110.73388285
100Glucagon signaling pathway_Homo sapiens_hsa049220.70771474
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69510905
102Autoimmune thyroid disease_Homo sapiens_hsa053200.69169459
103Fatty acid metabolism_Homo sapiens_hsa012120.67623748
104Non-small cell lung cancer_Homo sapiens_hsa052230.67237588
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66194139
106Peroxisome_Homo sapiens_hsa041460.65311998
107Butanoate metabolism_Homo sapiens_hsa006500.63780151
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63149561
109Insulin signaling pathway_Homo sapiens_hsa049100.62785788
110Endometrial cancer_Homo sapiens_hsa052130.61812098
111Serotonergic synapse_Homo sapiens_hsa047260.60427745
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60295729
113Chronic myeloid leukemia_Homo sapiens_hsa052200.59699428
114Proteasome_Homo sapiens_hsa030500.59653549
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58487861
116Oocyte meiosis_Homo sapiens_hsa041140.57742952
117Fructose and mannose metabolism_Homo sapiens_hsa000510.57698557
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56886753
119Acute myeloid leukemia_Homo sapiens_hsa052210.56634972
120Insulin resistance_Homo sapiens_hsa049310.55879437
121Rheumatoid arthritis_Homo sapiens_hsa053230.55169976
122Vitamin B6 metabolism_Homo sapiens_hsa007500.53642437
123Arginine and proline metabolism_Homo sapiens_hsa003300.53170572
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.52527369
125Bile secretion_Homo sapiens_hsa049760.52378859
126Colorectal cancer_Homo sapiens_hsa052100.50743877
127Epstein-Barr virus infection_Homo sapiens_hsa051690.49115900
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48906456
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46537280
130Thyroid cancer_Homo sapiens_hsa052160.46247201
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45229145
132p53 signaling pathway_Homo sapiens_hsa041150.44637725
133GABAergic synapse_Homo sapiens_hsa047270.44169975
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44084724
135Viral carcinogenesis_Homo sapiens_hsa052030.43183738
136Circadian entrainment_Homo sapiens_hsa047130.42336342
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42260967
138Glutathione metabolism_Homo sapiens_hsa004800.40580657
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40219846
140Steroid biosynthesis_Homo sapiens_hsa001000.40154616
141beta-Alanine metabolism_Homo sapiens_hsa004100.39000472
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36011352
143ABC transporters_Homo sapiens_hsa020100.35704337
144mRNA surveillance pathway_Homo sapiens_hsa030150.35099655
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35076948
146RNA degradation_Homo sapiens_hsa030180.34663834
147VEGF signaling pathway_Homo sapiens_hsa043700.33475540
148Glycerolipid metabolism_Homo sapiens_hsa005610.33147878
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32275493
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31777122
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.31240650
152Olfactory transduction_Homo sapiens_hsa047400.30529140
153Metabolic pathways_Homo sapiens_hsa011000.29990210

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