SYAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.19248746
2low-density lipoprotein particle clearance (GO:0034383)5.06798331
3valine metabolic process (GO:0006573)4.76385083
4L-phenylalanine catabolic process (GO:0006559)4.74522188
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.74522188
6L-phenylalanine metabolic process (GO:0006558)4.65164908
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65164908
8regulation of sequestering of triglyceride (GO:0010889)4.53413625
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53023883
10positive regulation of fatty acid beta-oxidation (GO:0032000)4.50936134
11sulfur amino acid catabolic process (GO:0000098)4.49289168
12cysteine metabolic process (GO:0006534)4.37626176
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32768852
14biotin metabolic process (GO:0006768)4.31887065
15fatty acid beta-oxidation (GO:0006635)4.11767402
16plasma lipoprotein particle clearance (GO:0034381)4.10045208
17positive regulation of fatty acid oxidation (GO:0046321)4.08785434
18aromatic amino acid family catabolic process (GO:0009074)4.06578432
19lysine catabolic process (GO:0006554)3.99919856
20lysine metabolic process (GO:0006553)3.99919856
21fatty acid oxidation (GO:0019395)3.98840230
22complement activation, alternative pathway (GO:0006957)3.95420644
23homocysteine metabolic process (GO:0050667)3.93507475
24lipid oxidation (GO:0034440)3.91511427
25regulation of triglyceride catabolic process (GO:0010896)3.91421324
26triglyceride catabolic process (GO:0019433)3.89026746
27regulation of cholesterol storage (GO:0010885)3.84256842
28fatty acid transmembrane transport (GO:1902001)3.80965461
29regulation of fatty acid beta-oxidation (GO:0031998)3.79524326
30ketone body metabolic process (GO:1902224)3.79089841
31positive regulation of lipid catabolic process (GO:0050996)3.79018720
32protein carboxylation (GO:0018214)3.78950691
33peptidyl-glutamic acid carboxylation (GO:0017187)3.78950691
34triglyceride homeostasis (GO:0070328)3.78605371
35acylglycerol homeostasis (GO:0055090)3.78605371
36serine family amino acid catabolic process (GO:0009071)3.77710392
37amino-acid betaine metabolic process (GO:0006577)3.75766894
38acylglycerol catabolic process (GO:0046464)3.74532465
39neutral lipid catabolic process (GO:0046461)3.74532465
40fatty acid catabolic process (GO:0009062)3.71766030
41glyoxylate metabolic process (GO:0046487)3.68097593
42bile acid biosynthetic process (GO:0006699)3.63078550
43urea metabolic process (GO:0019627)3.55134819
44urea cycle (GO:0000050)3.55134819
45regulation of hippo signaling (GO:0035330)3.53666096
462-oxoglutarate metabolic process (GO:0006103)3.53526894
47acetyl-CoA metabolic process (GO:0006084)3.51866658
48negative regulation of fibrinolysis (GO:0051918)3.50471424
49regulation of protein activation cascade (GO:2000257)3.48096480
50negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.45950176
51kynurenine metabolic process (GO:0070189)3.45874688
52indole-containing compound catabolic process (GO:0042436)3.45109006
53indolalkylamine catabolic process (GO:0046218)3.45109006
54tryptophan catabolic process (GO:0006569)3.45109006
55UDP-N-acetylglucosamine metabolic process (GO:0006047)3.44358643
56branched-chain amino acid metabolic process (GO:0009081)3.43221967
57positive regulation of fatty acid metabolic process (GO:0045923)3.43016201
58sulfation (GO:0051923)3.41863820
59regulation of cholesterol homeostasis (GO:2000188)3.40665634
60branched-chain amino acid catabolic process (GO:0009083)3.38614185
61short-chain fatty acid metabolic process (GO:0046459)3.38545619
62ethanol oxidation (GO:0006069)3.37326830
63regulation of complement activation (GO:0030449)3.36549069
64monocarboxylic acid catabolic process (GO:0072329)3.36149535
65bile acid metabolic process (GO:0008206)3.35581852
66regulation of fatty acid oxidation (GO:0046320)3.34497385
67high-density lipoprotein particle remodeling (GO:0034375)3.33843123
68carnitine shuttle (GO:0006853)3.32603563
69tryptophan metabolic process (GO:0006568)3.31163942
70reverse cholesterol transport (GO:0043691)3.29147237
71epoxygenase P450 pathway (GO:0019373)3.27518792
72tricarboxylic acid metabolic process (GO:0072350)3.26848944
73nitrogen cycle metabolic process (GO:0071941)3.25960335
74positive regulation of triglyceride metabolic process (GO:0090208)3.25068421
75rRNA catabolic process (GO:0016075)3.24128148
76behavioral response to nicotine (GO:0035095)3.23657269
77cellular ketone body metabolic process (GO:0046950)3.22622571
78replication fork processing (GO:0031297)3.21897163
79pantothenate metabolic process (GO:0015939)3.21659994
80regulation of hexokinase activity (GO:1903299)3.21333584
81regulation of glucokinase activity (GO:0033131)3.21333584
82protein K6-linked ubiquitination (GO:0085020)3.18988685
83drug transmembrane transport (GO:0006855)3.18634621
84carnitine metabolic process (GO:0009437)3.15465554
85triglyceride metabolic process (GO:0006641)3.14435449
86regulation of fibrinolysis (GO:0051917)3.12793887
87phospholipid homeostasis (GO:0055091)3.11371060
88regulation of DNA endoreduplication (GO:0032875)3.08688646
89protein-lipid complex remodeling (GO:0034368)3.07231820
90macromolecular complex remodeling (GO:0034367)3.07231820
91plasma lipoprotein particle remodeling (GO:0034369)3.07231820
92proteasome assembly (GO:0043248)3.05433919
93alpha-amino acid catabolic process (GO:1901606)3.04774990
94triglyceride biosynthetic process (GO:0019432)3.04371463
95acylglycerol biosynthetic process (GO:0046463)3.03649846
96neutral lipid biosynthetic process (GO:0046460)3.03649846
97phospholipid efflux (GO:0033700)3.03637795
98fatty acid homeostasis (GO:0055089)3.02938533
99carboxylic acid catabolic process (GO:0046395)3.01201645
100organic acid catabolic process (GO:0016054)3.01201645
101pseudouridine synthesis (GO:0001522)3.00443508
102aromatic amino acid family metabolic process (GO:0009072)2.99918482
103acylglycerol metabolic process (GO:0006639)2.99806481
104cellular amino acid catabolic process (GO:0009063)2.99439803
105negative regulation of fatty acid biosynthetic process (GO:0045717)2.97346411
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96769765
107lipoprotein metabolic process (GO:0042157)2.96504610
108signal transduction involved in regulation of gene expression (GO:0023019)2.95385390
109neutral lipid metabolic process (GO:0006638)2.94375008
110urate metabolic process (GO:0046415)2.92972261
111acyl-CoA biosynthetic process (GO:0071616)2.92392355
112thioester biosynthetic process (GO:0035384)2.92392355
113positive regulation of lipid storage (GO:0010884)2.91707546
114regulation of triglyceride metabolic process (GO:0090207)2.89562295
115water-soluble vitamin biosynthetic process (GO:0042364)2.88842416
116regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88767228
117protein K11-linked deubiquitination (GO:0035871)2.85802562
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.85266817
119NADH dehydrogenase complex assembly (GO:0010257)2.85266817
120mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85266817
121mitochondrial respiratory chain complex assembly (GO:0033108)2.77225401
122negative regulation of DNA-dependent DNA replication (GO:2000104)2.76211803
123reciprocal meiotic recombination (GO:0007131)2.75938498
124reciprocal DNA recombination (GO:0035825)2.75938498
125nephron tubule morphogenesis (GO:0072078)2.74916701
126nephron epithelium morphogenesis (GO:0072088)2.74916701
1273-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.73717256
128purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.73717256
129regulation of mesoderm development (GO:2000380)2.73710068
130protein complex biogenesis (GO:0070271)2.73628266
131respiratory chain complex IV assembly (GO:0008535)2.71557689
132flavonoid metabolic process (GO:0009812)2.71048607
133double-strand break repair via homologous recombination (GO:0000724)2.68952078
134recombinational repair (GO:0000725)2.66620232
135replicative senescence (GO:0090399)2.65542971
136intestinal epithelial cell development (GO:0060576)2.65167903
137regulation of centriole replication (GO:0046599)2.64659144
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63539351
139keratinocyte development (GO:0003334)2.62432982
140mitochondrial RNA metabolic process (GO:0000959)2.62195516
141drug catabolic process (GO:0042737)2.60429949
142regulation of acyl-CoA biosynthetic process (GO:0050812)2.58857145
143exogenous drug catabolic process (GO:0042738)2.58369396
144spindle assembly involved in mitosis (GO:0090307)2.56934754
145DNA replication checkpoint (GO:0000076)2.55945974
146meiotic chromosome segregation (GO:0045132)2.52500257
147dorsal/ventral axis specification (GO:0009950)2.52178533
148maturation of SSU-rRNA (GO:0030490)2.52042764
149regulation of mesenchymal cell apoptotic process (GO:2001053)2.49825578
150resolution of meiotic recombination intermediates (GO:0000712)2.49184301
151L-fucose catabolic process (GO:0042355)2.48090849
152fucose catabolic process (GO:0019317)2.48090849
153L-fucose metabolic process (GO:0042354)2.48090849
154maturation of 5.8S rRNA (GO:0000460)2.48006740
155mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.47845635
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.45616892
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44135553
158mitochondrion morphogenesis (GO:0070584)2.40762633
159magnesium ion transport (GO:0015693)2.39582908
160cornea development in camera-type eye (GO:0061303)2.39226944
161peptidyl-histidine modification (GO:0018202)2.37694741
162oxidative demethylation (GO:0070989)2.35741968
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35435196
164regulation of centrosome cycle (GO:0046605)2.31946549
165cytochrome complex assembly (GO:0017004)2.31859000
166indolalkylamine metabolic process (GO:0006586)2.31850616
167negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.29773870
168negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26589711
169quaternary ammonium group transport (GO:0015697)2.26420040
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.24406793
171negative regulation of T cell differentiation in thymus (GO:0033085)2.23734579
172L-methionine salvage (GO:0071267)2.23092337
173L-methionine biosynthetic process (GO:0071265)2.23092337
174amino acid salvage (GO:0043102)2.23092337
175maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.20736555
176ncRNA catabolic process (GO:0034661)2.19228848
177energy coupled proton transport, down electrochemical gradient (GO:0015985)2.18886645
178ATP synthesis coupled proton transport (GO:0015986)2.18886645
179methionine biosynthetic process (GO:0009086)2.17876279
180organic cation transport (GO:0015695)2.17682104
181somatic diversification of immune receptors via somatic mutation (GO:0002566)2.17565107
182somatic hypermutation of immunoglobulin genes (GO:0016446)2.17565107
183cellular biogenic amine catabolic process (GO:0042402)2.17421925
184amine catabolic process (GO:0009310)2.17421925
185cilium or flagellum-dependent cell motility (GO:0001539)2.16493200
186preassembly of GPI anchor in ER membrane (GO:0016254)2.15914715
187thyroid hormone metabolic process (GO:0042403)2.15804932
188cellular response to ATP (GO:0071318)2.15123372
189regulation of cofactor metabolic process (GO:0051193)2.14895421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.55151358
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.47236670
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.80456319
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.11634862
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.80343064
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.04161728
7CLOCK_20551151_ChIP-Seq_293T_Human4.02046384
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.50911531
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.44095954
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93279905
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.91098151
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.81954733
13ZNF274_21170338_ChIP-Seq_K562_Hela2.74487424
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74440073
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.72275357
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.57343346
17EWS_26573619_Chip-Seq_HEK293_Human2.52675459
18VDR_22108803_ChIP-Seq_LS180_Human2.45470620
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37324943
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35890565
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.33004732
22ELK1_19687146_ChIP-ChIP_HELA_Human2.30342788
23ZNF263_19887448_ChIP-Seq_K562_Human2.26300765
24FUS_26573619_Chip-Seq_HEK293_Human2.25120474
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.19484598
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.16677323
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06700726
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05404802
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98387795
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92201864
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87176835
32GATA1_22025678_ChIP-Seq_K562_Human1.85949741
33ER_23166858_ChIP-Seq_MCF-7_Human1.85099972
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83235561
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83190262
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80913700
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76457198
38IRF1_19129219_ChIP-ChIP_H3396_Human1.74717244
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.73432339
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71581226
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70432502
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.69661056
43MYC_18940864_ChIP-ChIP_HL60_Human1.69087365
44* VDR_23849224_ChIP-Seq_CD4+_Human1.68573523
45GBX2_23144817_ChIP-Seq_PC3_Human1.66960230
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.66581792
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.65680429
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64634818
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.64436696
50IGF1R_20145208_ChIP-Seq_DFB_Human1.64264136
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.62955759
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.61938913
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59271304
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55847344
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.55307500
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.55214506
57P300_19829295_ChIP-Seq_ESCs_Human1.54763845
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54661477
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53572061
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53384507
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52948948
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49379709
63TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48588672
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47636043
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46101105
66GATA4_25053715_ChIP-Seq_YYC3_Human1.44139224
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42430813
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.40315356
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38948264
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38284537
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37315595
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.36273316
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36238512
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35703536
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34453083
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33287394
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29822670
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25842105
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24444023
80TAF15_26573619_Chip-Seq_HEK293_Human1.24218766
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24081223
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23642101
83SOX2_20726797_ChIP-Seq_SW620_Human1.22946479
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22137941
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22137941
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21723065
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19887046
88HOXB7_26014856_ChIP-Seq_BT474_Human1.19139465
89* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.16941943
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16917333
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16801747
92STAT3_23295773_ChIP-Seq_U87_Human1.16241343
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16213636
94TCF4_22108803_ChIP-Seq_LS180_Human1.16002815
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15600059
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15155730
97TP53_16413492_ChIP-PET_HCT116_Human1.15112751
98CDX2_22108803_ChIP-Seq_LS180_Human1.14957768
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14332211
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13552643
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.13552643
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13144109
103SOX2_19829295_ChIP-Seq_ESCs_Human1.12666576
104NANOG_19829295_ChIP-Seq_ESCs_Human1.12666576
105SRF_21415370_ChIP-Seq_HL-1_Mouse1.12243865
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11792948
107HNF4A_19822575_ChIP-Seq_HepG2_Human1.11210965
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.10843088
109FOXP3_21729870_ChIP-Seq_TREG_Human1.10729098
110TP53_22573176_ChIP-Seq_HFKS_Human1.10697482
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09876646
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.09566740
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09494362
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09358448
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08785036
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08491724
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07721967
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07503015
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06956556
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06857506
121ATF3_27146783_Chip-Seq_COLON_Human1.06748213
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06583655
123DCP1A_22483619_ChIP-Seq_HELA_Human1.05669919
124BCAT_22108803_ChIP-Seq_LS180_Human1.04539783
125MYC_18555785_ChIP-Seq_MESCs_Mouse1.04188027
126SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03551438
127KDM5A_27292631_Chip-Seq_BREAST_Human1.03549481
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03199632
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02879730
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.02576799
131TCF4_23295773_ChIP-Seq_U87_Human1.02463543
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02417150
133E2F1_21310950_ChIP-Seq_MCF-7_Human1.02392185
134PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02201753
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.01906507
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01860983
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.00166639
138AR_25329375_ChIP-Seq_VCAP_Human0.99832111
139AR_20517297_ChIP-Seq_VCAP_Human0.99725364
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.99536487
141TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99400771
142CJUN_26792858_Chip-Seq_BT549_Human0.99215808
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99181741
144* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98443603
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.98208198
146SMAD4_21799915_ChIP-Seq_A2780_Human0.97954320
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97290464
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.95416618
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.95416618
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95180831
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94835609
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93941325
153GATA6_25053715_ChIP-Seq_YYC3_Human0.93705394
154RACK7_27058665_Chip-Seq_MCF-7_Human0.93406130
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92396185
156SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91557531
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90924081
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90544860
159GATA2_21666600_ChIP-Seq_HMVEC_Human0.88571714
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88552183
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.87036416
162THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86970365
163RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85750032
164SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80717774
165GATA1_19941826_ChIP-Seq_K562_Human0.79972438
166SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78145537
167SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78145537
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.74200819
169AR_21909140_ChIP-Seq_LNCAP_Human0.73618532
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73208539
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73150952
172TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72877407
173MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71821354
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71148145
175P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71013630
176RUNX1_27514584_Chip-Seq_MCF-7_Human0.70416481
177UBF1/2_26484160_Chip-Seq_HMECs_Human0.69258306
178JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69049403
179SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68474577
180PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68465600
181GATA2_19941826_ChIP-Seq_K562_Human0.68410278
182SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67857809
183BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67774550
184BRD4_25478319_ChIP-Seq_HGPS_Human0.66353998
185SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66155418
186TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66046302
187PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63448746
188RXR_22108803_ChIP-Seq_LS180_Human0.63358694
189ZNF217_24962896_ChIP-Seq_MCF-7_Human0.63039498
190JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62991417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.30716267
2MP0005360_urolithiasis4.88449783
3MP0005365_abnormal_bile_salt4.28033703
4MP0005085_abnormal_gallbladder_physiolo3.58593724
5MP0005670_abnormal_white_adipose3.11494720
6MP0010329_abnormal_lipoprotein_level3.07538463
7MP0008875_abnormal_xenobiotic_pharmacok2.92995708
8MP0008438_abnormal_cutaneous_collagen2.85636348
9MP0003705_abnormal_hypodermis_morpholog2.82859668
10MP0003195_calcinosis2.79982253
11MP0003252_abnormal_bile_duct2.75818984
12MP0002160_abnormal_reproductive_system2.63248121
13MP0002938_white_spotting2.54354560
14MP0009840_abnormal_foam_cell2.53155486
15MP0005666_abnormal_adipose_tissue2.50516201
16MP0004130_abnormal_muscle_cell2.43309678
17MP0003191_abnormal_cellular_cholesterol2.40832758
18MP0004185_abnormal_adipocyte_glucose2.33503573
19MP0000427_abnormal_hair_cycle2.26885083
20MP0005332_abnormal_amino_acid2.20112798
21MP0000569_abnormal_digit_pigmentation2.15540913
22MP0008057_abnormal_DNA_replication2.15364283
23MP0003806_abnormal_nucleotide_metabolis2.11961911
24MP0001666_abnormal_nutrient_absorption2.11673336
25MP0002118_abnormal_lipid_homeostasis2.02763070
26MP0000609_abnormal_liver_physiology1.99459676
27MP0005389_reproductive_system_phenotype1.93728981
28MP0005275_abnormal_skin_tensile1.91766426
29MP0003718_maternal_effect1.91075746
30MP0010234_abnormal_vibrissa_follicle1.87229156
31MP0003937_abnormal_limbs/digits/tail_de1.85998539
32MP0003941_abnormal_skin_development1.84955568
33MP0005375_adipose_tissue_phenotype1.84019188
34MP0008058_abnormal_DNA_repair1.81482755
35MP0003693_abnormal_embryo_hatching1.80798776
36MP0001919_abnormal_reproductive_system1.76468642
37MP0000013_abnormal_adipose_tissue1.75167448
38MP0004019_abnormal_vitamin_homeostasis1.70336206
39MP0001661_extended_life_span1.67164937
40MP0002971_abnormal_brown_adipose1.66131789
41MP0005174_abnormal_tail_pigmentation1.65823026
42MP0000372_irregular_coat_pigmentation1.63062482
43MP0006292_abnormal_olfactory_placode1.58373415
44MP0000383_abnormal_hair_follicle1.57698792
45MP0005319_abnormal_enzyme/_coenzyme1.57448546
46MP0009643_abnormal_urine_homeostasis1.56674127
47MP0010030_abnormal_orbit_morphology1.54120565
48MP0005408_hypopigmentation1.51455404
49MP0005083_abnormal_biliary_tract1.51017223
50MP0008872_abnormal_physiological_respon1.49113781
51MP0003300_gastrointestinal_ulcer1.43421039
52MP0008877_abnormal_DNA_methylation1.42030314
53MP0004957_abnormal_blastocyst_morpholog1.38077287
54MP0000003_abnormal_adipose_tissue1.37751179
55MP0005551_abnormal_eye_electrophysiolog1.36228303
56MP0002138_abnormal_hepatobiliary_system1.36001687
57MP0003890_abnormal_embryonic-extraembry1.35810289
58MP0003646_muscle_fatigue1.35501090
59MP0002102_abnormal_ear_morphology1.33587758
60MP0003136_yellow_coat_color1.33315266
61MP0000647_abnormal_sebaceous_gland1.32107249
62MP0002837_dystrophic_cardiac_calcinosis1.31955919
63MP0004264_abnormal_extraembryonic_tissu1.30961747
64MP0005334_abnormal_fat_pad1.28683201
65MP0010678_abnormal_skin_adnexa1.25890995
66MP0003950_abnormal_plasma_membrane1.25630351
67MP0003786_premature_aging1.24497863
68MP0001756_abnormal_urination1.24223781
69MP0005187_abnormal_penis_morphology1.20907937
70MP0010094_abnormal_chromosome_stability1.20607188
71MP0005058_abnormal_lysosome_morphology1.20577640
72MP0003186_abnormal_redox_activity1.19795357
73MP0002876_abnormal_thyroid_physiology1.19289857
74MP0005584_abnormal_enzyme/coenzyme_acti1.16349075
75MP0009115_abnormal_fat_cell1.15521249
76MP0002234_abnormal_pharynx_morphology1.15094479
77MP0004272_abnormal_basement_membrane1.14874263
78MP0004133_heterotaxia1.14696474
79MP0001485_abnormal_pinna_reflex1.10829123
80MP0000631_abnormal_neuroendocrine_gland1.10441001
81MP0002098_abnormal_vibrissa_morphology1.09891213
82MP0001764_abnormal_homeostasis1.08512755
83MP0003936_abnormal_reproductive_system1.06711546
84MP0001293_anophthalmia1.06035937
85MP0004147_increased_porphyrin_level1.04941181
86MP0002078_abnormal_glucose_homeostasis1.04928706
87MP0001986_abnormal_taste_sensitivity1.03776392
88MP0005167_abnormal_blood-brain_barrier1.03768320
89MP0002060_abnormal_skin_morphology1.02464177
90MP0009384_cardiac_valve_regurgitation1.02425006
91MP0002877_abnormal_melanocyte_morpholog1.02315955
92MP0000598_abnormal_liver_morphology1.01422337
93MP0009697_abnormal_copulation0.99603503
94MP0003868_abnormal_feces_composition0.98393049
95MP0004043_abnormal_pH_regulation0.98055476
96MP0005646_abnormal_pituitary_gland0.97674061
97MP0002254_reproductive_system_inflammat0.97063353
98MP0001286_abnormal_eye_development0.96861040
99MP0002277_abnormal_respiratory_mucosa0.96720984
100MP0005535_abnormal_body_temperature0.96056167
101MP0006072_abnormal_retinal_apoptosis0.95460429
102MP0000604_amyloidosis0.94470045
103MP0005451_abnormal_body_composition0.93156690
104MP0005220_abnormal_exocrine_pancreas0.92989751
105MP0000537_abnormal_urethra_morphology0.92830013
106MP0002168_other_aberrant_phenotype0.92726453
107MP0000516_abnormal_urinary_system0.92608274
108MP0005367_renal/urinary_system_phenotyp0.92608274
109MP0003690_abnormal_glial_cell0.92239421
110MP0001873_stomach_inflammation0.92212961
111MP0009250_abnormal_appendicular_skeleto0.92049856
112MP0003755_abnormal_palate_morphology0.91756101
113MP0000470_abnormal_stomach_morphology0.90664125
114MP0002084_abnormal_developmental_patter0.90198685
115MP0003567_abnormal_fetal_cardiomyocyte0.90087335
116MP0009780_abnormal_chondrocyte_physiolo0.88994386
117MP0001881_abnormal_mammary_gland0.88053212
118MP0003119_abnormal_digestive_system0.87926265
119MP0000049_abnormal_middle_ear0.86347495
120MP0003942_abnormal_urinary_system0.85447214
121MP0008995_early_reproductive_senescence0.84032992
122MP0003077_abnormal_cell_cycle0.83472285
123MP0005448_abnormal_energy_balance0.83122044
124MP0005647_abnormal_sex_gland0.83072327
125MP0003724_increased_susceptibility_to0.81058145
126MP0002210_abnormal_sex_determination0.80757956
127MP0002095_abnormal_skin_pigmentation0.80672537
128MP0008007_abnormal_cellular_replicative0.80541574
129MP0000627_abnormal_mammary_gland0.79354237
130MP0003566_abnormal_cell_adhesion0.79236761
131MP0009053_abnormal_anal_canal0.79186382
132MP0002136_abnormal_kidney_physiology0.78967075
133MP0009763_increased_sensitivity_to0.78604811
134MP0002970_abnormal_white_adipose0.78522881
135MP0010368_abnormal_lymphatic_system0.78446742
136MP0004215_abnormal_myocardial_fiber0.78047403
137MP0005636_abnormal_mineral_homeostasis0.77985936
138MP0005266_abnormal_metabolism0.76412156
139MP0001958_emphysema0.76237228
140MP0002163_abnormal_gland_morphology0.75959508
141MP0006035_abnormal_mitochondrial_morpho0.75352518
142MP0000653_abnormal_sex_gland0.75160298
143MP0002909_abnormal_adrenal_gland0.75057765
144MP0001697_abnormal_embryo_size0.74676548
145MP0002295_abnormal_pulmonary_circulatio0.74464405
146MP0008775_abnormal_heart_ventricle0.74063986
147MP0006138_congestive_heart_failure0.74022055
148MP0002796_impaired_skin_barrier0.73538451
149MP0001119_abnormal_female_reproductive0.72933036
150MP0001929_abnormal_gametogenesis0.71641059
151MP0009764_decreased_sensitivity_to0.70234203
152MP0002166_altered_tumor_susceptibility0.69822127
153MP0002896_abnormal_bone_mineralization0.68879388
154MP0009642_abnormal_blood_homeostasis0.68720669
155MP0003959_abnormal_lean_body0.68620788
156MP0008469_abnormal_protein_level0.67939689
157MP0003221_abnormal_cardiomyocyte_apopto0.67220573
158MP0005076_abnormal_cell_differentiation0.66476885
159MP0003656_abnormal_erythrocyte_physiolo0.63123116
160MP0005084_abnormal_gallbladder_morpholo0.62359807
161MP0005164_abnormal_response_to0.61116455
162MP0005377_hearing/vestibular/ear_phenot0.60125567
163MP0003878_abnormal_ear_physiology0.60125567
164MP0001944_abnormal_pancreas_morphology0.59575168
165MP0006036_abnormal_mitochondrial_physio0.58627413
166MP0003045_fibrosis0.58609908
167MP0010352_gastrointestinal_tract_polyps0.58390591
168MP0005395_other_phenotype0.58346580
169MP0008961_abnormal_basal_metabolism0.57782812
170MP0001533_abnormal_skeleton_physiology0.57596593
171MP0005248_abnormal_Harderian_gland0.57334752
172MP0000230_abnormal_systemic_arterial0.55825185
173MP0004782_abnormal_surfactant_physiolog0.55426897
174MP0003953_abnormal_hormone_level0.55079001
175MP0005023_abnormal_wound_healing0.54351190

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.01424881
2Xanthomatosis (HP:0000991)4.81604743
3Deep venous thrombosis (HP:0002625)4.50949622
4Abnormality of glycine metabolism (HP:0010895)4.42339130
5Abnormality of serine family amino acid metabolism (HP:0010894)4.42339130
6Hypoglycemic coma (HP:0001325)4.37806170
7Hyperglycinemia (HP:0002154)4.30288073
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.27758150
9Abnormality of alanine metabolism (HP:0010916)4.27758150
10Hyperalaninemia (HP:0003348)4.27758150
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26131305
12Intrahepatic cholestasis (HP:0001406)4.10367058
13Complement deficiency (HP:0004431)3.90841388
14Hyperlipoproteinemia (HP:0010980)3.88366479
15Pancreatic cysts (HP:0001737)3.78855825
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.77190659
17Hyperammonemia (HP:0001987)3.66589817
18Hypoalphalipoproteinemia (HP:0003233)3.62942654
19Abnormality of fatty-acid metabolism (HP:0004359)3.61551448
20Epidermoid cyst (HP:0200040)3.56803224
21Ketosis (HP:0001946)3.56725499
22Concave nail (HP:0001598)3.54355875
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.52747731
24Myocardial infarction (HP:0001658)3.48619054
25Hypobetalipoproteinemia (HP:0003563)3.48014000
26Hypolipoproteinemia (HP:0010981)3.41286376
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32309296
28Ketoacidosis (HP:0001993)3.22189521
29Pancreatic fibrosis (HP:0100732)3.17456556
30Abnormality of the common coagulation pathway (HP:0010990)3.17335437
31Molar tooth sign on MRI (HP:0002419)3.15932788
32Abnormality of midbrain morphology (HP:0002418)3.15932788
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12564328
34Prolonged partial thromboplastin time (HP:0003645)3.12538358
35Gout (HP:0001997)3.10635345
36Abnormality of the intrinsic pathway (HP:0010989)3.02492834
37Oligomenorrhea (HP:0000876)2.99194441
38Abnormality of purine metabolism (HP:0004352)2.96234359
39Abnormality of the renal cortex (HP:0011035)2.93317972
40Hydroxyprolinuria (HP:0003080)2.92488806
41Abnormality of proline metabolism (HP:0010907)2.92488806
42Hyperglycemia (HP:0003074)2.91329025
43Hypoplasia of the uterus (HP:0000013)2.90957231
44Skin nodule (HP:0200036)2.82637714
45Furrowed tongue (HP:0000221)2.80152864
46Abnormal cartilage morphology (HP:0002763)2.78732753
47True hermaphroditism (HP:0010459)2.76035631
48Abnormality of complement system (HP:0005339)2.75916975
49Hypercholesterolemia (HP:0003124)2.66753204
50Conjunctival hamartoma (HP:0100780)2.66279566
51Chronic hepatic failure (HP:0100626)2.65627710
52Abnormal pancreas size (HP:0012094)2.63714693
53Dicarboxylic aciduria (HP:0003215)2.62569774
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62569774
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.61895607
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.57046122
57Abnormality of serum amino acid levels (HP:0003112)2.56805191
58Nausea (HP:0002018)2.55095445
59Premature rupture of membranes (HP:0001788)2.54433692
60Hypoglycemic seizures (HP:0002173)2.51762366
61Congenital, generalized hypertrichosis (HP:0004540)2.51013501
62Fat malabsorption (HP:0002630)2.50877469
63Aplasia/hypoplasia of the uterus (HP:0008684)2.50820717
64Hypertriglyceridemia (HP:0002155)2.49683112
65Tubular atrophy (HP:0000092)2.48637943
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.46732361
67Acanthosis nigricans (HP:0000956)2.45569110
68Joint hemorrhage (HP:0005261)2.45387412
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43775004
70Abnormality of nucleobase metabolism (HP:0010932)2.36915303
71Hyperuricemia (HP:0002149)2.33162549
72Increased purine levels (HP:0004368)2.33162549
73Bilateral microphthalmos (HP:0007633)2.31560165
74Meckel diverticulum (HP:0002245)2.30744506
75Protrusio acetabuli (HP:0003179)2.30655209
76Insulin-resistant diabetes mellitus (HP:0000831)2.30242930
77Nephronophthisis (HP:0000090)2.29674079
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29586043
79Abnormality of chromosome stability (HP:0003220)2.29465702
80Microretrognathia (HP:0000308)2.28679059
81Renal cortical cysts (HP:0000803)2.26127697
82Hemorrhage of the eye (HP:0011885)2.25649759
83Birth length less than 3rd percentile (HP:0003561)2.25627641
84Generalized aminoaciduria (HP:0002909)2.25580937
85Abnormality of the ileum (HP:0001549)2.24463353
86Large for gestational age (HP:0001520)2.24346275
87Hamartoma of the eye (HP:0010568)2.24187504
88Esophageal varix (HP:0002040)2.23729987
89Polycythemia (HP:0001901)2.21883518
90Increased CSF lactate (HP:0002490)2.19136132
91Abnormality of the pons (HP:0007361)2.17933198
92Ankle contracture (HP:0006466)2.17470608
93Chromsome breakage (HP:0040012)2.17113658
94Pancreatitis (HP:0001733)2.15252515
95Global brain atrophy (HP:0002283)2.13191475
96Systemic lupus erythematosus (HP:0002725)2.12048966
97Hepatocellular carcinoma (HP:0001402)2.10738089
98Congenital stationary night blindness (HP:0007642)2.10708150
99Myoglobinuria (HP:0002913)2.10005998
100Metabolic acidosis (HP:0001942)2.08830789
101Conjugated hyperbilirubinemia (HP:0002908)2.08340542
102Abnormality of the preputium (HP:0100587)2.07950205
103Insulin resistance (HP:0000855)2.05646429
104Abnormality of the renal medulla (HP:0100957)2.05233477
105Absent thumb (HP:0009777)2.03110563
106Hyperinsulinemic hypoglycemia (HP:0000825)2.02633561
107Osteolytic defects of the phalanges of the hand (HP:0009771)2.02627460
108Osteolytic defects of the hand bones (HP:0009699)2.02627460
109Cerebellar dysplasia (HP:0007033)2.01123190
110Unilateral renal agenesis (HP:0000122)2.00107348
111Turricephaly (HP:0000262)1.99606322
112Sensorimotor neuropathy (HP:0007141)1.99419441
113Short tibia (HP:0005736)1.99241115
114Hypoplasia of the pons (HP:0012110)1.99233530
115Irritability (HP:0000737)1.98681699
116Peritonitis (HP:0002586)1.98556020
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.97213626
118Spastic diplegia (HP:0001264)1.96860784
119Cystic liver disease (HP:0006706)1.96616249
120Acute encephalopathy (HP:0006846)1.96110378
121Chorioretinal atrophy (HP:0000533)1.96031129
122Meningioma (HP:0002858)1.95543265
123Lethargy (HP:0001254)1.95107912
124Abnormality of the carotid arteries (HP:0005344)1.93536820
125Cardiovascular calcification (HP:0011915)1.93204054
126Progressive inability to walk (HP:0002505)1.92828263
127Nephritis (HP:0000123)1.92438950
128Brushfield spots (HP:0001088)1.92190078
129Hyperventilation (HP:0002883)1.92173807
130Sclerocornea (HP:0000647)1.92065252
131Abnormality of methionine metabolism (HP:0010901)1.90576405
132Spontaneous abortion (HP:0005268)1.89832372
133Multiple enchondromatosis (HP:0005701)1.87919336
134Type II lissencephaly (HP:0007260)1.87785533
135Congenital sensorineural hearing impairment (HP:0008527)1.87264860
136Increased connective tissue (HP:0009025)1.84912067
137Symptomatic seizures (HP:0011145)1.84092502
138Male pseudohermaphroditism (HP:0000037)1.83874696
139Right ventricular cardiomyopathy (HP:0011663)1.83545380
140Proximal tubulopathy (HP:0000114)1.82934009
141Abnormality of the nasal septum (HP:0000419)1.80444913
142Cerebral aneurysm (HP:0004944)1.80364014
143Short hallux (HP:0010109)1.80153849
144Triphalangeal thumb (HP:0001199)1.80032774
145Abnormality of urine glucose concentration (HP:0011016)1.79815612
146Glycosuria (HP:0003076)1.79815612
147Vascular calcification (HP:0004934)1.79774838
148Broad metatarsal (HP:0001783)1.78689203
149Rhinitis (HP:0012384)1.78633556
150Lymphangioma (HP:0100764)1.78561822
151Glomerulonephritis (HP:0000099)1.77861661
152Back pain (HP:0003418)1.77240324
153Increased serum lactate (HP:0002151)1.75578036
154Severe muscular hypotonia (HP:0006829)1.75416602
155Fibular aplasia (HP:0002990)1.74859920
156Abnormality of the proximal phalanges of the hand (HP:0009834)1.74772636
157Acute necrotizing encephalopathy (HP:0006965)1.74573938
158Increased corneal curvature (HP:0100692)1.73449868
159Keratoconus (HP:0000563)1.73449868
160Neoplasm of the adrenal cortex (HP:0100641)1.72405416
161Late onset (HP:0003584)1.72366895
162Attenuation of retinal blood vessels (HP:0007843)1.72028508
163Steatorrhea (HP:0002570)1.70442593
164Mitochondrial inheritance (HP:0001427)1.70397432
165Hypoplasia of the fovea (HP:0007750)1.70275896
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.70275896
167Tetraparesis (HP:0002273)1.70080763
168Clubbing of toes (HP:0100760)1.68894990
169Vomiting (HP:0002013)1.67839579
170Protuberant abdomen (HP:0001538)1.67510704
171Aplasia/Hypoplasia of the patella (HP:0006498)1.67405551
172Delayed CNS myelination (HP:0002188)1.67387857
173Mitral stenosis (HP:0001718)1.67080279
174Hematochezia (HP:0002573)1.66820168
175Hepatic necrosis (HP:0002605)1.66451857
176Dynein arm defect of respiratory motile cilia (HP:0012255)1.65488624
177Absent/shortened dynein arms (HP:0200106)1.65488624
178Breast carcinoma (HP:0003002)1.64526568
1793-Methylglutaconic aciduria (HP:0003535)1.64327124
180Small hand (HP:0200055)1.64160866
181Decreased circulating renin level (HP:0003351)1.64073059
182Oligohydramnios (HP:0001562)1.62702211
183Pendular nystagmus (HP:0012043)1.62231480
184Inability to walk (HP:0002540)1.60682336
185Hepatocellular necrosis (HP:0001404)1.59979679
186Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59970415
187Sloping forehead (HP:0000340)1.59927997
188Posterior subcapsular cataract (HP:0007787)1.59070674
189Preaxial hand polydactyly (HP:0001177)1.58526486
190Medial flaring of the eyebrow (HP:0010747)1.57483430
191Abnormal number of erythroid precursors (HP:0012131)1.56971643
192Fair hair (HP:0002286)1.56751787
193Cerebral edema (HP:0002181)1.56139284
194Anencephaly (HP:0002323)1.55948282
195Aplasia/Hypoplasia of the hallux (HP:0008362)1.55896482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.81327563
2BCKDK4.25798404
3ERN13.63459817
4SIK13.37622436
5CAMK1D2.94618736
6ZAK2.66232888
7TLK12.64476345
8FRK2.63549981
9LATS12.58608388
10FGFR42.57155765
11PBK2.41807378
12BMPR1B2.40206045
13GRK12.28964184
14PKN22.25522002
15MST42.21071364
16RIPK12.12334529
17BRSK22.11651787
18PDK31.98196016
19PDK41.98196016
20STK391.96582867
21MST1R1.92890548
22PDGFRA1.90361738
23ADRBK21.89014445
24BUB11.84922764
25PTK61.83374131
26CAMK1G1.82408567
27WEE11.77276797
28DDR21.76700431
29INSRR1.68084056
30TRIM281.64087522
31EIF2AK31.62536266
32MAP3K121.60031312
33MKNK21.54026338
34MAPKAPK31.52263636
35PDK21.48878254
36OXSR11.42951484
37MUSK1.42699525
38TTK1.34370055
39NEK11.33409193
40NEK91.30283557
41FGFR31.26773318
42FGFR21.26444839
43MAP3K31.25608231
44STK31.25436753
45PNCK1.23555479
46JAK11.23488395
47PINK11.22759379
48TTN1.22206996
49EPHB11.21938966
50TGFBR21.21695924
51TIE11.20807716
52TAF11.18779485
53MAP3K21.16338858
54PRKAA21.14377863
55MAP2K11.11675763
56CHEK21.10504416
57TYK21.09240904
58NEK21.08658787
59PRKCI1.07776398
60ACVR1B1.07723242
61MELK1.06582949
62PLK31.05885593
63STK161.05117150
64PIK3CG1.04685584
65JAK21.02761077
66TNIK1.02030016
67CDK61.01324302
68PAK31.00963618
69RPS6KB20.99599668
70MET0.99359382
71LATS20.97392628
72PLK10.97241598
73ADRBK10.96610285
74MAPKAPK50.95966606
75MAP2K20.95697911
76WNK40.95296225
77FER0.95030795
78VRK10.94836355
79PTK20.93913440
80EPHB20.92936841
81CASK0.91913878
82TAOK30.90101331
83PRKAA10.88065189
84ERBB30.87671031
85MAP4K20.85551958
86LMTK20.83878163
87STK38L0.83070410
88EIF2AK10.80091896
89MTOR0.79796309
90TRPM70.77894880
91MAPK110.77555270
92GSK3A0.77504735
93EPHA30.76968257
94RET0.76629209
95KSR20.76027066
96PDPK10.75973362
97PDGFRB0.75718099
98MKNK10.75449838
99FLT30.75442497
100BMX0.73198483
101NUAK10.71316917
102IRAK30.70859783
103MYLK0.70818035
104MAP2K30.70699651
105PLK40.70006000
106TBK10.69439020
107RPS6KA40.69199189
108TSSK60.69124812
109ABL20.68653648
110FGFR10.66861077
111CDC70.66798797
112DYRK1B0.66319175
113PRKCE0.66189452
114CDK90.63614077
115LRRK20.63208119
116TGFBR10.61996417
117SCYL20.61934194
118VRK20.61482418
119WNK30.59969304
120EIF2AK20.59069733
121JAK30.57736226
122TYRO30.55953317
123EEF2K0.53706082
124ERBB40.53684221
125LIMK10.53175898
126PAK20.52663777
127EPHA20.52444263
128RPS6KA50.52334852
129NLK0.51379302
130CSK0.51316203
131ATR0.50695588
132AURKB0.50292210
133IGF1R0.48119742
134PRKCG0.48051874
135MAP3K100.47745772
136PIK3CA0.47736531
137PDK10.47287502
138PRKACG0.46174273
139CAMKK20.45287092
140MAP3K70.43926445
141NME20.43180240
142KDR0.42110268
143BMPR20.41972601
144ILK0.41953341
145SRPK10.40344628
146BRSK10.38802298
147IRAK10.38362106
148PHKG20.38109536
149PHKG10.38109536
150CDK40.37849392
151BCR0.37259567
152CSNK2A10.37233109
153EGFR0.36255473
154ATM0.36135203
155AKT30.35237127
156PRKCH0.34977192
157MAPK130.34651193
158CSNK1G10.34432423
159PRKD10.34152411
160CCNB10.33555030
161MAP3K50.31401148
162MAPK150.31267169
163ABL10.31017506
164MAP2K40.30148709
165SGK30.29631610
166PRKCZ0.28998555
167CHUK0.28665331
168INSR0.28337278
169MAP3K10.27607990

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.15009152
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.04513463
3Fatty acid degradation_Homo sapiens_hsa000712.99082934
4PPAR signaling pathway_Homo sapiens_hsa033202.78908425
5Propanoate metabolism_Homo sapiens_hsa006402.74131521
6Nitrogen metabolism_Homo sapiens_hsa009102.72884757
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.69271034
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61507270
9Fatty acid metabolism_Homo sapiens_hsa012122.48556745
10Tryptophan metabolism_Homo sapiens_hsa003802.28665158
11Homologous recombination_Homo sapiens_hsa034402.10027038
12Butanoate metabolism_Homo sapiens_hsa006502.08272276
13Arginine biosynthesis_Homo sapiens_hsa002202.07038905
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02454473
15Oxidative phosphorylation_Homo sapiens_hsa001902.00572931
16Complement and coagulation cascades_Homo sapiens_hsa046102.00086891
17Peroxisome_Homo sapiens_hsa041461.95779357
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91518982
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91275250
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89871260
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88452592
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87670182
23Caffeine metabolism_Homo sapiens_hsa002321.87295704
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83634432
25beta-Alanine metabolism_Homo sapiens_hsa004101.83043581
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80153324
27Fanconi anemia pathway_Homo sapiens_hsa034601.79159839
28RNA polymerase_Homo sapiens_hsa030201.72417994
29Ribosome_Homo sapiens_hsa030101.71328717
30Basal transcription factors_Homo sapiens_hsa030221.68541670
31Sulfur metabolism_Homo sapiens_hsa009201.67739910
32Fatty acid biosynthesis_Homo sapiens_hsa000611.64992859
33One carbon pool by folate_Homo sapiens_hsa006701.64101028
34Protein export_Homo sapiens_hsa030601.61996443
35Fat digestion and absorption_Homo sapiens_hsa049751.61843568
36Vitamin B6 metabolism_Homo sapiens_hsa007501.58904577
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54191093
38Pyruvate metabolism_Homo sapiens_hsa006201.52124112
39Parkinsons disease_Homo sapiens_hsa050121.46746538
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46162705
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45373380
42Huntingtons disease_Homo sapiens_hsa050161.42238537
43Glycerolipid metabolism_Homo sapiens_hsa005611.41607016
44Staphylococcus aureus infection_Homo sapiens_hsa051501.41456351
45Proteasome_Homo sapiens_hsa030501.40285036
46Chemical carcinogenesis_Homo sapiens_hsa052041.38208350
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37908866
48Carbon metabolism_Homo sapiens_hsa012001.36092778
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35193919
50Starch and sucrose metabolism_Homo sapiens_hsa005001.33814781
51Histidine metabolism_Homo sapiens_hsa003401.32139808
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.31673056
53Bile secretion_Homo sapiens_hsa049761.29593459
54Selenocompound metabolism_Homo sapiens_hsa004501.25900397
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24780914
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.23089700
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.22586443
58Nucleotide excision repair_Homo sapiens_hsa034201.18773542
59Phenylalanine metabolism_Homo sapiens_hsa003601.16677462
60Vitamin digestion and absorption_Homo sapiens_hsa049771.16565813
61RNA degradation_Homo sapiens_hsa030181.16419294
62Folate biosynthesis_Homo sapiens_hsa007901.15876791
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14706781
64Non-homologous end-joining_Homo sapiens_hsa034501.11765475
65Adipocytokine signaling pathway_Homo sapiens_hsa049201.10454092
66Retinol metabolism_Homo sapiens_hsa008301.09138296
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08754455
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07292996
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06709403
70ABC transporters_Homo sapiens_hsa020101.06454290
71RNA transport_Homo sapiens_hsa030131.05395824
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04717858
73p53 signaling pathway_Homo sapiens_hsa041151.01538824
74Pyrimidine metabolism_Homo sapiens_hsa002400.99333998
75Fatty acid elongation_Homo sapiens_hsa000620.98950928
76Alzheimers disease_Homo sapiens_hsa050100.96581423
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96016856
78Insulin resistance_Homo sapiens_hsa049310.94700419
79Tyrosine metabolism_Homo sapiens_hsa003500.92614295
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91123093
81Phototransduction_Homo sapiens_hsa047440.90891087
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90154452
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89097527
84Ether lipid metabolism_Homo sapiens_hsa005650.88186016
85TGF-beta signaling pathway_Homo sapiens_hsa043500.85238320
86Purine metabolism_Homo sapiens_hsa002300.84719591
87Biosynthesis of amino acids_Homo sapiens_hsa012300.83924278
88Mismatch repair_Homo sapiens_hsa034300.83172649
89Sulfur relay system_Homo sapiens_hsa041220.79133619
90AMPK signaling pathway_Homo sapiens_hsa041520.77760949
91Lysine degradation_Homo sapiens_hsa003100.76143744
92Pentose phosphate pathway_Homo sapiens_hsa000300.75441336
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.72795662
94Arachidonic acid metabolism_Homo sapiens_hsa005900.71839846
95Sphingolipid metabolism_Homo sapiens_hsa006000.69176643
96Arginine and proline metabolism_Homo sapiens_hsa003300.64028706
97DNA replication_Homo sapiens_hsa030300.62116184
98Glutathione metabolism_Homo sapiens_hsa004800.61064260
99Hedgehog signaling pathway_Homo sapiens_hsa043400.60383598
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58645885
101Hippo signaling pathway_Homo sapiens_hsa043900.57777056
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.57675654
103Lysosome_Homo sapiens_hsa041420.54397663
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53554604
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53527797
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.52649601
107N-Glycan biosynthesis_Homo sapiens_hsa005100.50120542
108Protein digestion and absorption_Homo sapiens_hsa049740.48270351
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45979670
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45072777
111Insulin signaling pathway_Homo sapiens_hsa049100.44598008
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44414808
113Cardiac muscle contraction_Homo sapiens_hsa042600.44317915
114Circadian rhythm_Homo sapiens_hsa047100.43626767
115Basal cell carcinoma_Homo sapiens_hsa052170.43275355
116Olfactory transduction_Homo sapiens_hsa047400.42962170
117Cell cycle_Homo sapiens_hsa041100.42135440
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41839397
119Glucagon signaling pathway_Homo sapiens_hsa049220.40874914
120Steroid biosynthesis_Homo sapiens_hsa001000.40276985
121ECM-receptor interaction_Homo sapiens_hsa045120.39216559
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38111759
123Prion diseases_Homo sapiens_hsa050200.34291210
124Amoebiasis_Homo sapiens_hsa051460.33851145
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33027333
126Galactose metabolism_Homo sapiens_hsa000520.31903267
127Renin-angiotensin system_Homo sapiens_hsa046140.29363099
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27709272
129Fructose and mannose metabolism_Homo sapiens_hsa000510.27595926
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26640542
131Metabolic pathways_Homo sapiens_hsa011000.26227051
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24570813
133Focal adhesion_Homo sapiens_hsa045100.23604498
134Mineral absorption_Homo sapiens_hsa049780.23452840
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21481022
136Regulation of autophagy_Homo sapiens_hsa041400.20713696
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16400403
138Thyroid hormone synthesis_Homo sapiens_hsa049180.14945483
139Small cell lung cancer_Homo sapiens_hsa052220.14253620
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.14068712
141Type II diabetes mellitus_Homo sapiens_hsa049300.13740232
142Ovarian steroidogenesis_Homo sapiens_hsa049130.13267900
143mTOR signaling pathway_Homo sapiens_hsa041500.13113345
144Linoleic acid metabolism_Homo sapiens_hsa005910.11815980
145FoxO signaling pathway_Homo sapiens_hsa040680.11036129
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.10484409
147Hepatitis C_Homo sapiens_hsa051600.09372650

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