SYBU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58460629
2synaptic vesicle maturation (GO:0016188)5.33386097
3synaptic vesicle exocytosis (GO:0016079)5.32427316
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28425049
5vocalization behavior (GO:0071625)5.19608188
6locomotory exploration behavior (GO:0035641)5.18557258
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.04973862
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03208105
9glutamate secretion (GO:0014047)5.01028028
10protein localization to synapse (GO:0035418)4.82819537
11neuron cell-cell adhesion (GO:0007158)4.82449517
12regulation of synaptic vesicle exocytosis (GO:2000300)4.80569007
13regulation of glutamate receptor signaling pathway (GO:1900449)4.62476791
14layer formation in cerebral cortex (GO:0021819)4.56180011
15neurotransmitter-gated ion channel clustering (GO:0072578)4.43690349
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.35089094
17exploration behavior (GO:0035640)4.33443180
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.32140540
19regulation of synapse structural plasticity (GO:0051823)4.26091178
20regulation of synaptic vesicle transport (GO:1902803)4.25639543
21glutamate receptor signaling pathway (GO:0007215)4.18306163
22neurotransmitter secretion (GO:0007269)4.14829523
23positive regulation of synapse maturation (GO:0090129)4.12021334
24cellular potassium ion homeostasis (GO:0030007)4.08969626
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08485324
26synaptic transmission, glutamatergic (GO:0035249)3.99905779
27regulation of neuronal synaptic plasticity (GO:0048168)3.93350754
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88811255
29neuronal action potential propagation (GO:0019227)3.88152139
30neuron recognition (GO:0008038)3.86501224
31neuron-neuron synaptic transmission (GO:0007270)3.85654749
32proline transport (GO:0015824)3.78497232
33positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.67797596
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67776680
35gamma-aminobutyric acid transport (GO:0015812)3.66180118
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.66025967
37establishment of mitochondrion localization (GO:0051654)3.65485962
38postsynaptic membrane organization (GO:0001941)3.62401371
39dendritic spine morphogenesis (GO:0060997)3.60432902
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.59042496
41sodium ion export (GO:0071436)3.58472352
42long-term memory (GO:0007616)3.58273484
43pyrimidine nucleobase catabolic process (GO:0006208)3.55438370
44dendrite morphogenesis (GO:0048813)3.54296827
45synaptic vesicle endocytosis (GO:0048488)3.53956073
46neuronal ion channel clustering (GO:0045161)3.52790497
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48867189
48positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48083295
49axonal fasciculation (GO:0007413)3.47552551
50neurotransmitter transport (GO:0006836)3.46540552
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.46379276
52cerebellar granule cell differentiation (GO:0021707)3.45242903
53cellular sodium ion homeostasis (GO:0006883)3.39506335
54transmission of nerve impulse (GO:0019226)3.38783396
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37012627
56response to auditory stimulus (GO:0010996)3.36634455
57regulation of postsynaptic membrane potential (GO:0060078)3.36214962
58cell migration in hindbrain (GO:0021535)3.34878404
59positive regulation of membrane potential (GO:0045838)3.32472148
60cell communication by electrical coupling (GO:0010644)3.32354002
61innervation (GO:0060384)3.31738004
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31086706
63long-term synaptic potentiation (GO:0060291)3.30685039
64auditory behavior (GO:0031223)3.29915975
65activation of protein kinase A activity (GO:0034199)3.29793787
66regulation of neurotransmitter secretion (GO:0046928)3.29179237
67regulation of dendritic spine morphogenesis (GO:0061001)3.29033097
68synapse assembly (GO:0007416)3.27745805
69regulation of vesicle fusion (GO:0031338)3.27399965
70regulation of synaptic plasticity (GO:0048167)3.24830278
71mechanosensory behavior (GO:0007638)3.24664802
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24596555
73response to pheromone (GO:0019236)3.24370969
74presynaptic membrane assembly (GO:0097105)3.23099717
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18229941
76cerebellar Purkinje cell differentiation (GO:0021702)3.17719242
77regulation of synapse maturation (GO:0090128)3.17386560
78regulation of neurotransmitter levels (GO:0001505)3.17222235
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.17009310
80L-amino acid import (GO:0043092)3.16723855
81potassium ion homeostasis (GO:0055075)3.11746654
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11553554
83prepulse inhibition (GO:0060134)3.11522791
84positive regulation of dendritic spine development (GO:0060999)3.08749130
85regulation of neurotransmitter transport (GO:0051588)3.08611853
86presynaptic membrane organization (GO:0097090)3.08355374
87neuromuscular process controlling balance (GO:0050885)3.07321187
88membrane depolarization during action potential (GO:0086010)3.07176912
89behavioral defense response (GO:0002209)3.04999598
90behavioral fear response (GO:0001662)3.04999598
91dendritic spine organization (GO:0097061)3.04914536
92amino acid import (GO:0043090)3.04720100
93response to histamine (GO:0034776)3.03056978
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02783478
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00792644
96nucleobase catabolic process (GO:0046113)3.00147291
97positive regulation of synapse assembly (GO:0051965)2.98602624
98membrane depolarization (GO:0051899)2.97434224
99axon ensheathment in central nervous system (GO:0032291)2.97370877
100central nervous system myelination (GO:0022010)2.97370877
101vesicle transport along microtubule (GO:0047496)2.97195358
102organelle transport along microtubule (GO:0072384)2.96298108
103central nervous system projection neuron axonogenesis (GO:0021952)2.95945205
104learning (GO:0007612)2.95294413
105negative regulation of microtubule polymerization (GO:0031115)2.94062773
106positive regulation of potassium ion transmembrane transport (GO:1901381)2.92415784
107acidic amino acid transport (GO:0015800)2.91946918
108regulation of voltage-gated calcium channel activity (GO:1901385)2.91630573
109detection of calcium ion (GO:0005513)2.90792992
110fear response (GO:0042596)2.90563460
111negative regulation of dendrite morphogenesis (GO:0050774)2.89829713
112regulation of dendritic spine development (GO:0060998)2.89207216
113potassium ion import (GO:0010107)2.87425998
114positive regulation of neurotransmitter secretion (GO:0001956)2.87217723
115membrane hyperpolarization (GO:0060081)2.87108915
116synapse organization (GO:0050808)2.86912076
117synaptic transmission (GO:0007268)2.85747581
118establishment of synaptic vesicle localization (GO:0097480)2.84490420
119synaptic vesicle transport (GO:0048489)2.84490420
120neurotransmitter uptake (GO:0001504)2.82805304
121startle response (GO:0001964)2.81789334
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81035586
123mitochondrion transport along microtubule (GO:0047497)2.81035586
124cochlea development (GO:0090102)2.80525896
125C4-dicarboxylate transport (GO:0015740)2.79957910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66672534
2GBX2_23144817_ChIP-Seq_PC3_Human3.82465173
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12232898
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01618041
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00145472
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75854185
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63602015
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63602015
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60925980
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55652043
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54687844
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.53078268
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50717387
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47714201
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45664103
16DROSHA_22980978_ChIP-Seq_HELA_Human2.35919425
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.31905311
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.27230851
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.27126162
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22656509
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.21728683
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20574894
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.16630744
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16419109
25AR_21572438_ChIP-Seq_LNCaP_Human2.13699825
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02310129
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94955461
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87971592
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83718907
30TAF15_26573619_Chip-Seq_HEK293_Human1.80696401
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78400703
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75187548
33SMAD4_21799915_ChIP-Seq_A2780_Human1.66291774
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62505403
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59449008
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58104723
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57354780
38P300_19829295_ChIP-Seq_ESCs_Human1.46679967
39ZNF274_21170338_ChIP-Seq_K562_Hela1.43910077
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.42752484
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38024891
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37799272
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.36677303
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36380703
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35914089
46AR_25329375_ChIP-Seq_VCAP_Human1.32681001
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.32499818
48* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31421905
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.31333607
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29809041
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.28918307
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28466403
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25958762
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25178314
55IGF1R_20145208_ChIP-Seq_DFB_Human1.23941987
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.23489113
57STAT3_23295773_ChIP-Seq_U87_Human1.21760074
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20808719
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18483066
60AR_19668381_ChIP-Seq_PC3_Human1.18107979
61RNF2_27304074_Chip-Seq_NSC_Mouse1.15725871
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14585042
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13975344
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13399945
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12863424
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11228518
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.11067863
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.08260140
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07845437
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07170878
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07009637
72TCF4_23295773_ChIP-Seq_U87_Human1.06667766
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05651961
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.05227815
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04133864
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.02705734
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02589028
78AHR_22903824_ChIP-Seq_MCF-7_Human1.02404308
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01204810
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00169723
81RUNX2_22187159_ChIP-Seq_PCA_Human0.99444731
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.99354251
83NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98962687
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98784257
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98019874
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97873596
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97037562
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96806528
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96806528
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.96524095
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96013238
92FUS_26573619_Chip-Seq_HEK293_Human0.95628537
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.95018873
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94274080
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93415221
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93038218
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92567098
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92393719
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.92034688
100JUN_21703547_ChIP-Seq_K562_Human0.91544235
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90821849
102TP53_18474530_ChIP-ChIP_U2OS_Human0.90086346
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89097445
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89093899
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88795862
106ER_23166858_ChIP-Seq_MCF-7_Human0.87950068
107KDM2B_26808549_Chip-Seq_K562_Human0.87936891
108BCAT_22108803_ChIP-Seq_LS180_Human0.87816158
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87434170
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87405719
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87126052
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86020544
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.85209451
114VDR_22108803_ChIP-Seq_LS180_Human0.84862992
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83995975
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83827993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.91316196
2MP0003880_abnormal_central_pattern4.62581174
3MP0003635_abnormal_synaptic_transmissio3.99912000
4MP0004270_analgesia3.77001270
5MP0002063_abnormal_learning/memory/cond3.28655821
6MP0009745_abnormal_behavioral_response3.20371839
7MP0001968_abnormal_touch/_nociception3.05384796
8MP0005423_abnormal_somatic_nervous3.04902473
9MP0009046_muscle_twitch2.96965246
10MP0002064_seizures2.95089888
11MP0002734_abnormal_mechanical_nocicepti2.80774532
12MP0002572_abnormal_emotion/affect_behav2.74957236
13MP0002735_abnormal_chemical_nociception2.55513115
14MP0001486_abnormal_startle_reflex2.47648603
15MP0002272_abnormal_nervous_system2.43636009
16MP0002736_abnormal_nociception_after2.41367000
17MP0001440_abnormal_grooming_behavior2.30393802
18MP0002733_abnormal_thermal_nociception2.26183727
19MP0003329_amyloid_beta_deposits2.19293160
20MP0000778_abnormal_nervous_system2.16376923
21MP0002822_catalepsy2.13998897
22MP0006276_abnormal_autonomic_nervous2.10411360
23MP0001970_abnormal_pain_threshold2.08797030
24MP0004858_abnormal_nervous_system2.07595075
25MP0001501_abnormal_sleep_pattern2.07549991
26MP0002184_abnormal_innervation2.07274220
27MP0002067_abnormal_sensory_capabilities2.06572624
28MP0001984_abnormal_olfaction1.98757254
29MP0004924_abnormal_behavior1.86541239
30MP0005386_behavior/neurological_phenoty1.86541239
31MP0009780_abnormal_chondrocyte_physiolo1.85721285
32MP0002557_abnormal_social/conspecific_i1.82681679
33MP0008569_lethality_at_weaning1.80744871
34MP0004811_abnormal_neuron_physiology1.72632820
35MP0002909_abnormal_adrenal_gland1.66447913
36MP0000955_abnormal_spinal_cord1.63532532
37MP0004885_abnormal_endolymph1.54625038
38MP0000566_synostosis1.54515499
39MP0001529_abnormal_vocalization1.53732582
40MP0005646_abnormal_pituitary_gland1.53476854
41MP0002882_abnormal_neuron_morphology1.50531942
42MP0001502_abnormal_circadian_rhythm1.50249199
43MP0003879_abnormal_hair_cell1.44825620
44MP0002066_abnormal_motor_capabilities/c1.41773674
45MP0001905_abnormal_dopamine_level1.35473409
46MP0005645_abnormal_hypothalamus_physiol1.34790619
47MP0004142_abnormal_muscle_tone1.32543885
48MP0005551_abnormal_eye_electrophysiolog1.27178980
49MP0003633_abnormal_nervous_system1.23713140
50MP0002152_abnormal_brain_morphology1.16999329
51MP0003787_abnormal_imprinting1.13247687
52MP0001188_hyperpigmentation1.11230770
53MP0003122_maternal_imprinting1.10359648
54MP0003631_nervous_system_phenotype1.09205136
55MP0004145_abnormal_muscle_electrophysio1.06138565
56MP0004742_abnormal_vestibular_system1.06090886
57MP0010386_abnormal_urinary_bladder1.06058579
58MP0002229_neurodegeneration1.04722650
59MP0000604_amyloidosis1.03508881
60MP0000751_myopathy1.03238767
61MP0002638_abnormal_pupillary_reflex0.97467741
62MP0002837_dystrophic_cardiac_calcinosis0.97409089
63MP0003634_abnormal_glial_cell0.96069480
64MP0008875_abnormal_xenobiotic_pharmacok0.95327515
65MP0008872_abnormal_physiological_respon0.95257890
66MP0005248_abnormal_Harderian_gland0.93400018
67MP0003121_genomic_imprinting0.91752312
68MP0002069_abnormal_eating/drinking_beha0.91584026
69MP0001346_abnormal_lacrimal_gland0.91414504
70MP0002752_abnormal_somatic_nervous0.90765104
71MP0005499_abnormal_olfactory_system0.90446958
72MP0005394_taste/olfaction_phenotype0.90446958
73MP0002090_abnormal_vision0.90283253
74MP0000631_abnormal_neuroendocrine_gland0.89945869
75MP0002653_abnormal_ependyma_morphology0.87310097
76MP0001963_abnormal_hearing_physiology0.87022258
77MP0004085_abnormal_heartbeat0.86105849
78MP0003137_abnormal_impulse_conducting0.86035870
79MP0004233_abnormal_muscle_weight0.85771493
80MP0000569_abnormal_digit_pigmentation0.85133324
81MP0003632_abnormal_nervous_system0.84529719
82MP0006072_abnormal_retinal_apoptosis0.83100396
83MP0005535_abnormal_body_temperature0.82226147
84MP0003123_paternal_imprinting0.81885041
85MP0004215_abnormal_myocardial_fiber0.81566248
86MP0004133_heterotaxia0.80477241
87MP0003690_abnormal_glial_cell0.78421584
88MP0000013_abnormal_adipose_tissue0.76731050
89MP0003938_abnormal_ear_development0.75128476
90MP0008789_abnormal_olfactory_epithelium0.74704561
91MP0008874_decreased_physiological_sensi0.73123756
92MP0001177_atelectasis0.71081210
93MP0002234_abnormal_pharynx_morphology0.67567171
94MP0002876_abnormal_thyroid_physiology0.67046846
95MP0001664_abnormal_digestion0.66787576
96MP0001299_abnormal_eye_distance/0.66661912
97MP0001485_abnormal_pinna_reflex0.65646950
98MP0003861_abnormal_nervous_system0.65217058
99MP0004147_increased_porphyrin_level0.64940319
100MP0000639_abnormal_adrenal_gland0.63666853
101MP0004484_altered_response_of0.63205986
102MP0005623_abnormal_meninges_morphology0.62883297
103MP0005187_abnormal_penis_morphology0.62769189
104MP0000579_abnormal_nail_morphology0.61187410
105MP0008961_abnormal_basal_metabolism0.60504758
106MP0005253_abnormal_eye_physiology0.60192807
107MP0000920_abnormal_myelination0.59915510
108MP0005409_darkened_coat_color0.59904150
109MP0000026_abnormal_inner_ear0.58035184
110MP0004043_abnormal_pH_regulation0.55900332
111MP0003075_altered_response_to0.55307870
112MP0001943_abnormal_respiration0.54142852
113MP0010769_abnormal_survival0.52315970
114MP0002082_postnatal_lethality0.51602311
115MP0010770_preweaning_lethality0.51602311
116MP0003956_abnormal_body_size0.49300789

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57999881
2Myokymia (HP:0002411)6.17560152
3Focal seizures (HP:0007359)5.17032828
4Visual hallucinations (HP:0002367)5.04277558
5Epileptic encephalopathy (HP:0200134)4.93707358
6Progressive cerebellar ataxia (HP:0002073)4.41433182
7Atonic seizures (HP:0010819)4.19200146
8Febrile seizures (HP:0002373)4.09480067
9Absence seizures (HP:0002121)4.01166586
10Supranuclear gaze palsy (HP:0000605)3.95654627
11Action tremor (HP:0002345)3.76768539
12Generalized tonic-clonic seizures (HP:0002069)3.68672012
13Dialeptic seizures (HP:0011146)3.60902208
14Broad-based gait (HP:0002136)3.58301152
15Mutism (HP:0002300)3.51383465
16Neurofibrillary tangles (HP:0002185)3.36171807
17Hyperventilation (HP:0002883)3.28996125
18Cerebral inclusion bodies (HP:0100314)3.24963721
19Ankle clonus (HP:0011448)3.23675411
20Abnormality of binocular vision (HP:0011514)3.17255570
21Diplopia (HP:0000651)3.17255570
22Poor eye contact (HP:0000817)3.13684128
23Truncal ataxia (HP:0002078)3.11158742
24Limb dystonia (HP:0002451)3.10843064
25Abnormal eating behavior (HP:0100738)3.10773091
26Dysdiadochokinesis (HP:0002075)3.06843059
27Gaze-evoked nystagmus (HP:0000640)3.02074896
28Depression (HP:0000716)3.01834671
29Polyphagia (HP:0002591)3.01454774
30Excessive salivation (HP:0003781)2.99668391
31Drooling (HP:0002307)2.99668391
32Hemiparesis (HP:0001269)2.99274068
33Papilledema (HP:0001085)2.93159216
34Genetic anticipation (HP:0003743)2.84547501
35Anxiety (HP:0000739)2.84243840
36Impaired vibration sensation in the lower limbs (HP:0002166)2.81539621
37Amblyopia (HP:0000646)2.81375930
38Abnormal social behavior (HP:0012433)2.80107295
39Impaired social interactions (HP:0000735)2.80107295
40Urinary bladder sphincter dysfunction (HP:0002839)2.79268271
41Dysmetria (HP:0001310)2.78974530
42Insidious onset (HP:0003587)2.77911437
43Termporal pattern (HP:0011008)2.77911437
44Abnormality of the corticospinal tract (HP:0002492)2.72948155
45Epileptiform EEG discharges (HP:0011182)2.69642775
46Megalencephaly (HP:0001355)2.68816929
47Amyotrophic lateral sclerosis (HP:0007354)2.68096797
48EEG with generalized epileptiform discharges (HP:0011198)2.63733803
49Scanning speech (HP:0002168)2.62042207
50Urinary urgency (HP:0000012)2.61900058
51Pheochromocytoma (HP:0002666)2.55330388
52Abnormality of the lower motor neuron (HP:0002366)2.55294692
53Torticollis (HP:0000473)2.54409059
54Gait imbalance (HP:0002141)2.52230296
55Spastic gait (HP:0002064)2.50288960
56Progressive inability to walk (HP:0002505)2.50034793
57Postural instability (HP:0002172)2.48526360
58Impaired smooth pursuit (HP:0007772)2.42453219
59Hypsarrhythmia (HP:0002521)2.41161807
60Bradykinesia (HP:0002067)2.36741801
61Agitation (HP:0000713)2.33078888
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.32970457
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32970457
64Focal dystonia (HP:0004373)2.30161247
65Hemiplegia (HP:0002301)2.29111838
66Abnormality of the labia minora (HP:0012880)2.27829081
67Split foot (HP:0001839)2.26415584
68Stereotypic behavior (HP:0000733)2.25798749
69Intention tremor (HP:0002080)2.25241648
70Fetal akinesia sequence (HP:0001989)2.22821615
71Abnormality of ocular smooth pursuit (HP:0000617)2.20888714
72Inability to walk (HP:0002540)2.19687125
73Lower limb muscle weakness (HP:0007340)2.17182193
74Neuroendocrine neoplasm (HP:0100634)2.17036354
75Absent speech (HP:0001344)2.13594016
76Akinesia (HP:0002304)2.12336175
77Craniofacial dystonia (HP:0012179)2.11750108
78Spastic tetraplegia (HP:0002510)2.09041713
79Obstructive sleep apnea (HP:0002870)2.05020884
80Morphological abnormality of the pyramidal tract (HP:0002062)2.03877732
81Status epilepticus (HP:0002133)2.02972933
82Dysmetric saccades (HP:0000641)2.02693817
83Poor suck (HP:0002033)2.02620698
84Specific learning disability (HP:0001328)2.01765822
85Tetraplegia (HP:0002445)1.99461800
86Abnormality of salivation (HP:0100755)1.97369126
87Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97276747
88Hypoplasia of the brainstem (HP:0002365)1.97276747
89Generalized myoclonic seizures (HP:0002123)1.96477419
90Abnormal respiratory epithelium morphology (HP:0012253)1.95973037
91Abnormal respiratory motile cilium morphology (HP:0005938)1.95973037
92Abnormal ciliary motility (HP:0012262)1.92934428
93Sleep apnea (HP:0010535)1.92625885
94Failure to thrive in infancy (HP:0001531)1.92015316
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91883818
96Hypoventilation (HP:0002791)1.91305955
97Gait ataxia (HP:0002066)1.91114842
98Neuronal loss in central nervous system (HP:0002529)1.89463659
99Impaired vibratory sensation (HP:0002495)1.88530587
100Inappropriate behavior (HP:0000719)1.88091344
101Cerebral hypomyelination (HP:0006808)1.87901401
102Delusions (HP:0000746)1.86754727
103Apathy (HP:0000741)1.85228954
104Abnormal respiratory motile cilium physiology (HP:0012261)1.84745767
105Lissencephaly (HP:0001339)1.84423374
106Genital tract atresia (HP:0001827)1.83329051
107Medial flaring of the eyebrow (HP:0010747)1.83258147
108Insomnia (HP:0100785)1.83243368
109Ventricular fibrillation (HP:0001663)1.82769309
110Pancreatic fibrosis (HP:0100732)1.82639976
111Psychosis (HP:0000709)1.80905533
112Nephrogenic diabetes insipidus (HP:0009806)1.80101135
113Incomplete penetrance (HP:0003829)1.78994085
114Rigidity (HP:0002063)1.78583275
115Congenital primary aphakia (HP:0007707)1.78556192
116True hermaphroditism (HP:0010459)1.77469830
117Clonus (HP:0002169)1.77304969
118Retinal dysplasia (HP:0007973)1.73812513
119Dyskinesia (HP:0100660)1.73464612
120Hypoplasia of the corpus callosum (HP:0002079)1.70258771
121Vaginal atresia (HP:0000148)1.69568244
122Muscular hypotonia of the trunk (HP:0008936)1.67737434
123Diminished movement (HP:0002374)1.66817447
124Hepatoblastoma (HP:0002884)1.65954490
125Rhinitis (HP:0012384)1.65403349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.78299147
2MAP3K93.89057084
3NTRK33.76472891
4EPHA43.43385194
5MAP3K43.13023963
6MINK12.85769417
7MAP2K72.55995616
8CASK2.48162099
9NTRK22.47982475
10DAPK22.23805507
11PAK62.10882257
12PHKG22.09555508
13PHKG12.09555508
14KSR21.84395341
15MAP3K121.83460305
16MAP2K41.82329216
17MAPK131.76942187
18KSR11.69384274
19NTRK11.62051700
20CDK51.51709915
21PLK21.51398061
22CAMKK11.50037089
23PRKD31.36966041
24TNIK1.32338705
25SIK21.32325906
26GRK51.31791721
27DAPK11.27693615
28LATS21.26959654
29PNCK1.26171927
30PRKCG1.20829905
31LMTK21.20479905
32CAMKK21.19395158
33CDK191.16975033
34RIPK41.16397831
35PRPF4B1.15781995
36CSNK1A1L1.12200015
37ARAF1.11861631
38EPHA31.01816215
39CSNK1G21.01323921
40CAMK2A1.00582885
41DYRK20.96982945
42DYRK1A0.96110328
43STK380.95689634
44UHMK10.93439956
45CDK180.93077972
46CSNK1G10.93064909
47TYRO30.91660144
48CDK140.91427864
49MAP3K130.90537890
50SGK4940.89481006
51SGK2230.89481006
52CDK150.89279130
53MAP3K20.87234113
54FES0.86468721
55PAK30.86198273
56RET0.85372333
57MARK20.82755743
58CDK11A0.76571818
59CAMK2B0.76518496
60SIK30.74606430
61STK110.74057882
62STK390.72605393
63CAMK10.72022117
64TAOK10.69978809
65TESK10.68632776
66ERBB30.68181901
67OXSR10.66795467
68TRIM280.66315477
69SGK20.66100125
70NEK60.66015518
71PINK10.65047105
72PTK2B0.64741382
73PRKCE0.64675128
74PRKCZ0.62436844
75MAP4K20.61518523
76CCNB10.61218637
77MAP3K60.60504269
78PRKCH0.59379445
79NME10.59116798
80SGK10.58432704
81FRK0.55948336
82PKN10.55195548
83MAPK120.55186384
84CAMK1G0.54142271
85RAF10.54051716
86AKT30.53057825
87MAPK150.52579804
88FGFR20.52055598
89WNK30.51809691
90ERBB20.51283075
91FER0.50395044
92WNK40.49973903
93CSNK1G30.49313542
94CAMK2D0.49031408
95FGR0.48365355
96BCR0.47375902
97BMPR20.47216736
98SGK30.45885279
99FYN0.44569958
100PRKACA0.43707174
101RPS6KA30.42998854
102CSNK1D0.42912790
103CAMK2G0.42850764
104NEK10.41242146
105BRSK10.40067838
106CSNK1A10.39974424
107PRKG10.39343654
108PDPK10.38945970
109MAP2K10.38727687
110SCYL20.38439262
111RPS6KA20.37938200
112PDK10.37580015
113RIPK10.37185256
114CSNK1E0.36824423
115RPS6KB10.36689863
116LIMK10.36396981
117ROCK20.35277015
118PRKCA0.35068095
119PRKAA10.34909949
120MAPK100.33652331
121CAMK40.33436863
122ADRBK10.32733729

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80171764
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39171708
3GABAergic synapse_Homo sapiens_hsa047272.77899071
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75706410
5Circadian entrainment_Homo sapiens_hsa047132.68067550
6Olfactory transduction_Homo sapiens_hsa047402.64087629
7Glutamatergic synapse_Homo sapiens_hsa047242.56795679
8Morphine addiction_Homo sapiens_hsa050322.52218324
9Long-term potentiation_Homo sapiens_hsa047202.44659328
10Amphetamine addiction_Homo sapiens_hsa050312.27940387
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21514819
12Dopaminergic synapse_Homo sapiens_hsa047282.21465514
13Salivary secretion_Homo sapiens_hsa049702.10006755
14Insulin secretion_Homo sapiens_hsa049111.99439411
15Cholinergic synapse_Homo sapiens_hsa047251.90082186
16Taste transduction_Homo sapiens_hsa047421.88910570
17Gastric acid secretion_Homo sapiens_hsa049711.75986567
18Renin secretion_Homo sapiens_hsa049241.74259816
19Serotonergic synapse_Homo sapiens_hsa047261.73444166
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70627437
21Long-term depression_Homo sapiens_hsa047301.70365122
22Cocaine addiction_Homo sapiens_hsa050301.64518711
23Collecting duct acid secretion_Homo sapiens_hsa049661.62807322
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60180442
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59520734
26Oxytocin signaling pathway_Homo sapiens_hsa049211.54197617
27Calcium signaling pathway_Homo sapiens_hsa040201.48262553
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42348403
29Gap junction_Homo sapiens_hsa045401.40948040
30Vitamin B6 metabolism_Homo sapiens_hsa007501.37636943
31GnRH signaling pathway_Homo sapiens_hsa049121.35667326
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28098651
33Axon guidance_Homo sapiens_hsa043601.27143516
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25782533
35cAMP signaling pathway_Homo sapiens_hsa040241.18291029
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17283710
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15504885
38Estrogen signaling pathway_Homo sapiens_hsa049151.09011777
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08786881
40Cardiac muscle contraction_Homo sapiens_hsa042601.07325802
41Type II diabetes mellitus_Homo sapiens_hsa049301.05266936
42Vibrio cholerae infection_Homo sapiens_hsa051101.03191695
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02425723
44Histidine metabolism_Homo sapiens_hsa003401.00343782
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00105915
46Melanogenesis_Homo sapiens_hsa049160.96495316
47Glioma_Homo sapiens_hsa052140.94779223
48ErbB signaling pathway_Homo sapiens_hsa040120.94659219
49Phototransduction_Homo sapiens_hsa047440.93583607
50Nitrogen metabolism_Homo sapiens_hsa009100.89748379
51Phenylalanine metabolism_Homo sapiens_hsa003600.86416394
52beta-Alanine metabolism_Homo sapiens_hsa004100.86011130
53Pancreatic secretion_Homo sapiens_hsa049720.85682048
54Arginine biosynthesis_Homo sapiens_hsa002200.84922518
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.84883724
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83785540
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.80100538
58Oocyte meiosis_Homo sapiens_hsa041140.77909319
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76793658
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75659570
61Dorso-ventral axis formation_Homo sapiens_hsa043200.74348899
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74275873
63Choline metabolism in cancer_Homo sapiens_hsa052310.70134428
64Thyroid hormone synthesis_Homo sapiens_hsa049180.69032234
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68424241
66Dilated cardiomyopathy_Homo sapiens_hsa054140.66883227
67Arginine and proline metabolism_Homo sapiens_hsa003300.66429948
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66283617
69Circadian rhythm_Homo sapiens_hsa047100.64025429
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63813570
71MAPK signaling pathway_Homo sapiens_hsa040100.63130797
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61043837
73Glucagon signaling pathway_Homo sapiens_hsa049220.60422715
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.59096148
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57710830
76Ras signaling pathway_Homo sapiens_hsa040140.57261267
77Alzheimers disease_Homo sapiens_hsa050100.57118899
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.56576300
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56143220
80Bile secretion_Homo sapiens_hsa049760.55859073
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55828775
82Alcoholism_Homo sapiens_hsa050340.54644472
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54344422
84AMPK signaling pathway_Homo sapiens_hsa041520.53146497
85VEGF signaling pathway_Homo sapiens_hsa043700.53048800
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53033458
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.52216685
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52052425
89Steroid biosynthesis_Homo sapiens_hsa001000.51122650
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49603947
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48735891
92Tyrosine metabolism_Homo sapiens_hsa003500.47962316
93Rap1 signaling pathway_Homo sapiens_hsa040150.46882722
94Renal cell carcinoma_Homo sapiens_hsa052110.46826395
95Endometrial cancer_Homo sapiens_hsa052130.45672399
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45524002
97Regulation of autophagy_Homo sapiens_hsa041400.44554381
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44367937
99Retinol metabolism_Homo sapiens_hsa008300.44035537
100Caffeine metabolism_Homo sapiens_hsa002320.43880266
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43864623
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42613259
103Inositol phosphate metabolism_Homo sapiens_hsa005620.42086430
104Insulin signaling pathway_Homo sapiens_hsa049100.41661693
105Oxidative phosphorylation_Homo sapiens_hsa001900.40608377
106mTOR signaling pathway_Homo sapiens_hsa041500.40351729
107Chemical carcinogenesis_Homo sapiens_hsa052040.39206614
108Endocytosis_Homo sapiens_hsa041440.39180989
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37465863
110Prion diseases_Homo sapiens_hsa050200.35978931
111Fatty acid biosynthesis_Homo sapiens_hsa000610.35872914
112Wnt signaling pathway_Homo sapiens_hsa043100.35662919
113Hippo signaling pathway_Homo sapiens_hsa043900.35349371
114Colorectal cancer_Homo sapiens_hsa052100.35260063
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35198581
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34782495
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.34722166
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34078984
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33197964
120Parkinsons disease_Homo sapiens_hsa050120.33168690
121Tight junction_Homo sapiens_hsa045300.32683473
122PPAR signaling pathway_Homo sapiens_hsa033200.32536708
123Ovarian steroidogenesis_Homo sapiens_hsa049130.32519429
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32418220
125ABC transporters_Homo sapiens_hsa020100.31846413
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30943096
127Linoleic acid metabolism_Homo sapiens_hsa005910.30392897
128Butanoate metabolism_Homo sapiens_hsa006500.28074302
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27928461

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »