SYCE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.76929821
2cell-cell recognition (GO:0009988)9.69347224
3male meiosis (GO:0007140)9.65307842
4axonemal dynein complex assembly (GO:0070286)9.24941408
5plasma membrane fusion (GO:0045026)9.24459844
6reproduction (GO:0000003)8.71712438
7acrosome reaction (GO:0007340)8.64644427
8epithelial cilium movement (GO:0003351)8.62289734
9spermatid development (GO:0007286)8.35601103
10motile cilium assembly (GO:0044458)7.67906425
11cilium movement (GO:0003341)7.63314603
12* synaptonemal complex organization (GO:0070193)7.58822593
13* synaptonemal complex assembly (GO:0007130)7.50750156
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39360726
15DNA methylation involved in gamete generation (GO:0043046)7.04581729
16regulation of cilium movement (GO:0003352)6.87633457
17single fertilization (GO:0007338)6.71686083
18sperm capacitation (GO:0048240)6.52975956
19meiotic nuclear division (GO:0007126)6.02121034
20male meiosis I (GO:0007141)5.99575597
21fertilization (GO:0009566)5.85371055
22* chromosome organization involved in meiosis (GO:0070192)5.70616643
23spermatogenesis (GO:0007283)5.48280825
24male gamete generation (GO:0048232)5.46816681
25resolution of meiotic recombination intermediates (GO:0000712)5.26979018
26germ cell development (GO:0007281)5.12547726
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.06778746
28gamete generation (GO:0007276)5.04186436
29microtubule depolymerization (GO:0007019)4.98212292
30ventricular system development (GO:0021591)4.95351923
31meiosis I (GO:0007127)4.93977514
32negative regulation of inclusion body assembly (GO:0090084)4.93576456
33histone H3-K9 demethylation (GO:0033169)4.88108833
34spermatid nucleus differentiation (GO:0007289)4.79346108
35microtubule severing (GO:0051013)4.69461189
36positive regulation of meiosis (GO:0045836)4.62427872
37monoubiquitinated protein deubiquitination (GO:0035520)4.57937679
38cell recognition (GO:0008037)4.55017397
39regulation of meiotic cell cycle (GO:0051445)4.52184420
40meiotic chromosome segregation (GO:0045132)4.47184491
41female gamete generation (GO:0007292)4.37560026
42positive regulation of meiotic cell cycle (GO:0051446)4.26498504
43gene silencing by RNA (GO:0031047)4.22523765
44organic cation transport (GO:0015695)4.21303833
45regulation of inclusion body assembly (GO:0090083)4.19997885
46meiotic cell cycle (GO:0051321)4.12398769
47regulation of microtubule-based movement (GO:0060632)4.09854265
48synapsis (GO:0007129)4.08823282
49seminiferous tubule development (GO:0072520)4.02193434
50nuclear pore complex assembly (GO:0051292)4.01502480
51regulation of centriole replication (GO:0046599)4.00339525
52calcium ion-dependent exocytosis (GO:0017156)3.97303930
53chaperone-mediated protein complex assembly (GO:0051131)3.93309917
54multicellular organismal reproductive process (GO:0048609)3.92569664
55regulation of meiosis I (GO:0060631)3.89741703
56positive regulation of cellular response to oxidative stress (GO:1900409)3.87575088
57positive regulation of response to oxidative stress (GO:1902884)3.87575088
58sex differentiation (GO:0007548)3.78658495
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.76766667
60protein polyglutamylation (GO:0018095)3.75921444
61* meiotic cell cycle process (GO:1903046)3.69405753
62genitalia morphogenesis (GO:0035112)3.62357054
63histone H3-K36 demethylation (GO:0070544)3.58844346
64synaptic vesicle exocytosis (GO:0016079)3.57623584
65negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.52588220
66nuclear pore organization (GO:0006999)3.50276827
67DNA biosynthetic process (GO:0071897)3.47936758
68intraciliary transport (GO:0042073)3.47413551
69synaptic vesicle maturation (GO:0016188)3.47375587
70protein localization to cilium (GO:0061512)3.47231996
71reproductive system development (GO:0061458)3.39535947
72negative regulation of organelle assembly (GO:1902116)3.35048803
73chromosome condensation (GO:0030261)3.31023532
74oogenesis (GO:0048477)3.30123997
75positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.24674765
76DNA packaging (GO:0006323)3.24139540
77protein K11-linked deubiquitination (GO:0035871)3.23253636
78regulation of spindle checkpoint (GO:0090231)3.22893625
79single strand break repair (GO:0000012)3.19450300
80gene silencing (GO:0016458)3.16562453
81centriole replication (GO:0007099)3.15438732
82glutamate secretion (GO:0014047)3.15125343
83histone exchange (GO:0043486)3.15076628
84DNA replication-dependent nucleosome assembly (GO:0006335)3.13342353
85DNA replication-dependent nucleosome organization (GO:0034723)3.13342353
86multicellular organismal development (GO:0007275)3.10713520
87regulation of histone H3-K9 methylation (GO:0051570)3.10037131
88regulation of synaptic vesicle exocytosis (GO:2000300)3.09343874
89left/right pattern formation (GO:0060972)3.07942217
90regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07751071
91pore complex assembly (GO:0046931)3.06212187
92regulation of hydrogen peroxide metabolic process (GO:0010310)3.01792113
93glycerol ether metabolic process (GO:0006662)3.01328935
94regulation of meiosis (GO:0040020)3.00622750
95DNA methylation (GO:0006306)2.99622897
96DNA alkylation (GO:0006305)2.99622897
97microtubule-based movement (GO:0007018)2.97825995
98histone H4-K12 acetylation (GO:0043983)2.96777600
99mitotic sister chromatid cohesion (GO:0007064)2.95186491
100nucleus organization (GO:0006997)2.94794929
101protein K6-linked ubiquitination (GO:0085020)2.94571405
102sister chromatid cohesion (GO:0007062)2.93710991
103regulation of protein polyubiquitination (GO:1902914)2.93693810
104centriole assembly (GO:0098534)2.92198694
105* chromosome organization (GO:0051276)2.91771800
106negative regulation of DNA repair (GO:0045738)2.85710580
107regulation of transcription from RNA polymerase I promoter (GO:0006356)2.81977375
108regulation of DNA endoreduplication (GO:0032875)2.80121274
109ether metabolic process (GO:0018904)2.77320005
110cilium organization (GO:0044782)2.76998318
111negative regulation of meiosis (GO:0045835)2.76163244
112iron-sulfur cluster assembly (GO:0016226)2.76154261
113metallo-sulfur cluster assembly (GO:0031163)2.76154261
114axoneme assembly (GO:0035082)2.73533466
115negative regulation of gene silencing (GO:0060969)2.73204337
116protein localization to chromosome (GO:0034502)2.73056030
117protein refolding (GO:0042026)2.71608161
118cellular hyperosmotic response (GO:0071474)2.70694485
119regulation of synaptic vesicle transport (GO:1902803)2.70133232
120carnitine transmembrane transport (GO:1902603)2.69224621
121lactate metabolic process (GO:0006089)2.69138918
122amino-acid betaine transport (GO:0015838)2.69022215
123carnitine transport (GO:0015879)2.69022215
124reciprocal DNA recombination (GO:0035825)2.67715956
125reciprocal meiotic recombination (GO:0007131)2.67715956
126embryonic heart tube development (GO:0035050)2.65548821
127microtubule polymerization or depolymerization (GO:0031109)2.63524813
128oocyte maturation (GO:0001556)2.63256416
129peptidyl-lysine dimethylation (GO:0018027)2.61916575
130DNA methylation or demethylation (GO:0044728)2.57541660
131nuclear division (GO:0000280)2.57158259
132neurotransmitter secretion (GO:0007269)2.56683413
133cerebellar Purkinje cell differentiation (GO:0021702)2.55332685
134regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.55096413
135proteasome assembly (GO:0043248)2.53251159
136positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47427666
137negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.46197381
138embryonic body morphogenesis (GO:0010172)2.45476677
139response to misfolded protein (GO:0051788)2.45238480
140histone H2A acetylation (GO:0043968)2.44874074
141neuronal action potential propagation (GO:0019227)2.44107252
142negative regulation of meiotic cell cycle (GO:0051447)2.43569445
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42581986
144mating behavior (GO:0007617)2.41398803
145regulation of female receptivity (GO:0045924)2.40246955
146organelle fission (GO:0048285)2.39548555
147postsynaptic membrane organization (GO:0001941)2.36881610
148attachment of spindle microtubules to kinetochore (GO:0008608)2.36048421
149regulation of voltage-gated calcium channel activity (GO:1901385)2.33922278
150signal complex assembly (GO:0007172)2.33770420
151cellular response to nitric oxide (GO:0071732)2.33448845
152positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.27987870
153locomotory exploration behavior (GO:0035641)2.27382823
154mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.22915046
155poly(A)+ mRNA export from nucleus (GO:0016973)2.21899078
156regulation of response to food (GO:0032095)2.21277304
157cilium or flagellum-dependent cell motility (GO:0001539)12.7272859
158DNA synthesis involved in DNA repair (GO:0000731)12.4490153
159fusion of sperm to egg plasma membrane (GO:0007342)12.2153773
160acrosome assembly (GO:0001675)11.5236528
161cell wall macromolecule metabolic process (GO:0044036)11.0735859
162cell wall macromolecule catabolic process (GO:0016998)11.0735859
163sperm motility (GO:0030317)10.8130688
164sperm-egg recognition (GO:0035036)10.8103646
165multicellular organism reproduction (GO:0032504)10.5704190
166piRNA metabolic process (GO:0034587)10.4453324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.17977705
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50556585
3EZH2_22144423_ChIP-Seq_EOC_Human3.23533033
4BMI1_23680149_ChIP-Seq_NPCS_Mouse2.96057971
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62021638
6CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.51905623
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.51882744
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45025163
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37279789
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34775101
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33685350
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23791961
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16804853
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.16038889
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11687237
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2759588
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.97591075
18KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94281858
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.93396889
20* SMC4_20622854_ChIP-Seq_HELA_Human1.89997634
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89686432
22P68_20966046_ChIP-Seq_HELA_Human1.89513610
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88999831
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86406162
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.85713671
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83563625
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82220117
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77545231
29* TET1_21490601_ChIP-Seq_MESCs_Mouse1.77524834
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77516192
31ZNF274_21170338_ChIP-Seq_K562_Hela1.73850315
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73122633
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.68330816
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.68218845
35REST_21632747_ChIP-Seq_MESCs_Mouse1.63579326
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.62916168
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.61492983
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59632216
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59316385
40VDR_22108803_ChIP-Seq_LS180_Human1.56373502
41ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55615255
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55198210
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55198210
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55198210
45ERA_21632823_ChIP-Seq_H3396_Human1.55072037
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.54304170
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.52027883
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49759535
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.49530036
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48653132
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47808620
52E2F7_22180533_ChIP-Seq_HELA_Human1.47288160
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44376381
54SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.43560666
55FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43446591
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41909530
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41909530
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41198167
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40109603
60STAT1_17558387_ChIP-Seq_HELA_Human1.39856026
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39366366
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39057858
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.38156078
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.36168628
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32565158
66CTCF_26484167_Chip-Seq_Bcells_Mouse1.32072523
67RNF2_27304074_Chip-Seq_NSC_Mouse1.31303945
68OCT4_19829295_ChIP-Seq_ESCs_Human1.30592710
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.29639831
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28894965
71* PHF8_20622854_ChIP-Seq_HELA_Human1.28115173
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.27926175
73GATA3_21867929_ChIP-Seq_TH1_Mouse1.26847969
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.26704061
75TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.23692482
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.23480838
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22381923
78KLF4_19829295_ChIP-Seq_ESCs_Human1.22240755
79RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21652477
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.20941963
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.19865295
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19631416
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19386524
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.18732368
85HTT_18923047_ChIP-ChIP_STHdh_Human1.17991976
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17887697
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17391989
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15860170
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.15817163
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15807043
91KDM2B_26808549_Chip-Seq_REH_Human1.15394002
92KDM2B_26808549_Chip-Seq_K562_Human1.15287014
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.15219602
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.14983245
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14631939
96CBP_20019798_ChIP-Seq_JUKART_Human1.14631939
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14036649
98STAT1_20625510_ChIP-Seq_HELA_Human1.13542685
99EED_16625203_ChIP-ChIP_MESCs_Mouse1.10936743
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10864080
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10452568
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.09192726
103BCOR_27268052_Chip-Seq_Bcells_Human1.08955886
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08903344
105* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08350856
106SOX2_21211035_ChIP-Seq_LN229_Human1.07983159
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.07957434
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07782566
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.07659859
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07372480
111P300_18555785_Chip-Seq_ESCs_Mouse1.06727917
112ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06242032
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05498977
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05221595
115BCL6_27268052_Chip-Seq_Bcells_Human1.04805765
116IGF1R_20145208_ChIP-Seq_DFB_Human1.04477497
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04118515
118* CTCF_27219007_Chip-Seq_Bcells_Human1.03543773
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02998932
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01157371
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01034862
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00786917
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00424100
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00147798
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.00120544
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99789720
127SPI1_26923725_Chip-Seq_HPCs_Mouse0.99700759
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.99380294
129P53_22387025_ChIP-Seq_ESCs_Mouse0.99004009
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98913653
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98703924
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98477603
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.95956863
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95421912
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.95310557
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95216987
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94902482
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94688900
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94593559
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.94359358
141FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93509818
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92586321
143P53_21459846_ChIP-Seq_SAOS-2_Human0.92355439
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92294531
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.92150125
146GF1_26923725_Chip-Seq_HPCs_Mouse0.92009872
147CTCF_18555785_Chip-Seq_ESCs_Mouse0.91923572
148DCP1A_22483619_ChIP-Seq_HELA_Human0.91890666
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91807540
150* E2F1_20622854_ChIP-Seq_HELA_Human0.91568457
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91466238
152TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90589161
153CTCF_20526341_ChIP-Seq_ESCs_Human0.89158904
154OCT4_20526341_ChIP-Seq_ESCs_Human0.88582142
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88283392
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87731543
157LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87522100
158KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87283171
159RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87030470
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.85435898
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84967373
162STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84732146
163SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84730445
164SOX2_18555785_Chip-Seq_ESCs_Mouse0.84578918
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84512912
166* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84490801
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82799775
168IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82777220
169E2F1_18555785_Chip-Seq_ESCs_Mouse0.82585027
170ZFX_18555785_Chip-Seq_ESCs_Mouse0.82543947
171SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81794643
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81787287
173RAC3_21632823_ChIP-Seq_H3396_Human0.81450549
174SOX9_26525672_Chip-Seq_HEART_Mouse0.81029928
175PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80989453
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80838448
177PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80671930
178CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79992913
179CREB1_26743006_Chip-Seq_LNCaP_Human0.79761223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.53207648
2* MP0003698_abnormal_male_reproductive5.73326423
3* MP0001929_abnormal_gametogenesis5.51238798
4* MP0002210_abnormal_sex_determination4.14227681
5MP0002653_abnormal_ependyma_morphology3.82102759
6* MP0001145_abnormal_male_reproductive3.52918932
7MP0004859_abnormal_synaptic_plasticity3.14187125
8* MP0002161_abnormal_fertility/fecundity3.13602134
9MP0008057_abnormal_DNA_replication3.12350411
10* MP0000653_abnormal_sex_gland3.07243135
11MP0003880_abnormal_central_pattern3.03725932
12MP0005423_abnormal_somatic_nervous2.93662497
13MP0000678_abnormal_parathyroid_gland2.69870543
14MP0010094_abnormal_chromosome_stability2.58606064
15MP0005623_abnormal_meninges_morphology2.54261120
16MP0003635_abnormal_synaptic_transmissio2.33090366
17MP0002064_seizures2.18357295
18MP0005410_abnormal_fertilization13.2370549
19MP0009745_abnormal_behavioral_response1.99683649
20MP0005646_abnormal_pituitary_gland1.98546414
21MP0001968_abnormal_touch/_nociception1.96774933
22MP0001502_abnormal_circadian_rhythm1.96731036
23MP0002063_abnormal_learning/memory/cond1.91747804
24MP0001486_abnormal_startle_reflex1.87592816
25MP0001346_abnormal_lacrimal_gland1.84932613
26MP0002160_abnormal_reproductive_system1.82440036
27MP0000013_abnormal_adipose_tissue1.80475624
28MP0002272_abnormal_nervous_system1.72935877
29MP0001986_abnormal_taste_sensitivity1.72757226
30MP0002736_abnormal_nociception_after1.69146313
31MP0003111_abnormal_nucleus_morphology1.68205549
32MP0003786_premature_aging1.66545259
33MP0003879_abnormal_hair_cell1.65337595
34* MP0008058_abnormal_DNA_repair1.61541780
35MP0001188_hyperpigmentation1.54298594
36MP0001501_abnormal_sleep_pattern1.53267806
37MP0008995_early_reproductive_senescence1.50080361
38MP0002249_abnormal_larynx_morphology1.48358817
39MP0008007_abnormal_cellular_replicative1.48067985
40MP0002572_abnormal_emotion/affect_behav1.44606597
41MP0008004_abnormal_stomach_pH1.42869473
42MP0004270_analgesia1.41361634
43MP0005670_abnormal_white_adipose1.35274148
44MP0009046_muscle_twitch1.34531958
45MP0002734_abnormal_mechanical_nocicepti1.33841407
46MP0003077_abnormal_cell_cycle1.33574775
47MP0002282_abnormal_trachea_morphology1.29075508
48MP0003329_amyloid_beta_deposits1.27007497
49MP0003693_abnormal_embryo_hatching1.26833508
50MP0005409_darkened_coat_color1.24546792
51MP0002733_abnormal_thermal_nociception1.23569650
52MP0003646_muscle_fatigue1.21916499
53MP0004957_abnormal_blastocyst_morpholog1.17949301
54MP0010307_abnormal_tumor_latency1.16328768
55MP0005647_abnormal_sex_gland1.13579713
56MP0004233_abnormal_muscle_weight1.11227851
57MP0001730_embryonic_growth_arrest1.09959061
58MP0000681_abnormal_thyroid_gland1.06767274
59MP0005389_reproductive_system_phenotype1.05825485
60MP0002067_abnormal_sensory_capabilities1.04187240
61MP0001970_abnormal_pain_threshold1.01356779
62MP0005645_abnormal_hypothalamus_physiol1.00350142
63MP0004811_abnormal_neuron_physiology0.97786155
64MP0008260_abnormal_autophagy0.96884679
65MP0008569_lethality_at_weaning0.94793614
66MP0002735_abnormal_chemical_nociception0.89520590
67MP0000955_abnormal_spinal_cord0.89184436
68MP0009379_abnormal_foot_pigmentation0.88028065
69MP0002066_abnormal_motor_capabilities/c0.87698935
70MP0002638_abnormal_pupillary_reflex0.85753335
71MP0000003_abnormal_adipose_tissue0.85269480
72MP0001293_anophthalmia0.83309738
73MP0004885_abnormal_endolymph0.80303361
74MP0002882_abnormal_neuron_morphology0.78967351
75MP0002557_abnormal_social/conspecific_i0.77479838
76MP0005386_behavior/neurological_phenoty0.77323554
77MP0004924_abnormal_behavior0.77323554
78MP0004133_heterotaxia0.76514082
79MP0003633_abnormal_nervous_system0.76303655
80MP0001440_abnormal_grooming_behavior0.73348580
81MP0002084_abnormal_developmental_patter0.70991635
82MP0000358_abnormal_cell_content/0.70804081
83MP0008932_abnormal_embryonic_tissue0.70098445
84MP0005377_hearing/vestibular/ear_phenot0.69940221
85MP0003878_abnormal_ear_physiology0.69940221
86MP0009780_abnormal_chondrocyte_physiolo0.69789956
87MP0003938_abnormal_ear_development0.69785252
88MP0005058_abnormal_lysosome_morphology0.69445191
89MP0001984_abnormal_olfaction0.69402748
90MP0000313_abnormal_cell_death0.68561997
91MP0000778_abnormal_nervous_system0.67712619
92MP0003123_paternal_imprinting0.66488694
93MP0003183_abnormal_peptide_metabolism0.65724789
94* MP0001119_abnormal_female_reproductive0.65183645
95* MP0003699_abnormal_female_reproductive0.65007186
96MP0005380_embryogenesis_phenotype0.64729078
97MP0001672_abnormal_embryogenesis/_devel0.64729078
98MP0003950_abnormal_plasma_membrane0.64400030
99MP0001765_abnormal_ion_homeostasis0.63498893
100MP0001697_abnormal_embryo_size0.63071957
101MP0002229_neurodegeneration0.62818900
102MP0002184_abnormal_innervation0.61310313
103MP0002085_abnormal_embryonic_tissue0.59978720
104MP0004808_abnormal_hematopoietic_stem0.59373880
105MP0003122_maternal_imprinting0.56387768
106MP0003984_embryonic_growth_retardation0.56254719
107MP0002876_abnormal_thyroid_physiology0.55639748
108MP0000350_abnormal_cell_proliferation0.54345624
109MP0003631_nervous_system_phenotype0.54114868
110MP0002080_prenatal_lethality0.54104387
111MP0002088_abnormal_embryonic_growth/wei0.52552071
112MP0000383_abnormal_hair_follicle0.52114333
113MP0004197_abnormal_fetal_growth/weight/0.51209663
114MP0001963_abnormal_hearing_physiology0.49784472
115MP0000604_amyloidosis0.49572278
116MP0000631_abnormal_neuroendocrine_gland0.49327875
117MP0000427_abnormal_hair_cycle0.48695001
118MP0004084_abnormal_cardiac_muscle0.47999092
119MP0002971_abnormal_brown_adipose0.47251647
120MP0001485_abnormal_pinna_reflex0.47247641
121MP0003690_abnormal_glial_cell0.46476245
122MP0004036_abnormal_muscle_relaxation0.46371382
123MP0003011_delayed_dark_adaptation0.45132842
124MP0005397_hematopoietic_system_phenotyp0.44445652
125MP0001545_abnormal_hematopoietic_system0.44445652
126MP0002269_muscular_atrophy0.44119630
127MP0006036_abnormal_mitochondrial_physio0.43756746
128MP0003861_abnormal_nervous_system0.41204318
129MP0005391_vision/eye_phenotype0.40583024
130MP0000569_abnormal_digit_pigmentation0.39599480
131MP0005253_abnormal_eye_physiology0.39244410
132MP0003890_abnormal_embryonic-extraembry0.38918062
133MP0005076_abnormal_cell_differentiation0.38656247
134MP0004134_abnormal_chest_morphology0.38452803
135MP0003115_abnormal_respiratory_system0.37961175
136MP0002086_abnormal_extraembryonic_tissu0.36858391
137MP0002928_abnormal_bile_duct0.35212510
138MP0003787_abnormal_imprinting0.34549623
139MP0002019_abnormal_tumor_incidence0.34434985
140MP0002092_abnormal_eye_morphology0.33241251
141MP0005266_abnormal_metabolism0.33024561
142MP0003936_abnormal_reproductive_system0.32768428
143MP0009672_abnormal_birth_weight0.32631726
144MP0000432_abnormal_head_morphology0.32086191
145MP0002234_abnormal_pharynx_morphology0.30994159
146MP0001919_abnormal_reproductive_system0.29937959
147MP0006072_abnormal_retinal_apoptosis0.29460031
148MP0009703_decreased_birth_body0.29232910
149MP0003718_maternal_effect0.28558794
150MP0004019_abnormal_vitamin_homeostasis0.27735563
151MP0001764_abnormal_homeostasis0.26475371
152MP0001727_abnormal_embryo_implantation0.26005991
153MP0002102_abnormal_ear_morphology0.25660607
154MP0001324_abnormal_eye_pigmentation0.25325403
155MP0005666_abnormal_adipose_tissue0.24857681
156MP0006035_abnormal_mitochondrial_morpho0.24692013
157MP0009278_abnormal_bone_marrow0.24469958
158MP0005636_abnormal_mineral_homeostasis0.23606419
159MP0003119_abnormal_digestive_system0.22089662
160MP0002152_abnormal_brain_morphology0.22085961
161MP0003806_abnormal_nucleotide_metabolis0.21953331
162MP0003121_genomic_imprinting0.21898570
163MP0000647_abnormal_sebaceous_gland0.19870071
164MP0010352_gastrointestinal_tract_polyps0.19146664
165MP0005551_abnormal_eye_electrophysiolog0.19134344

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.21002918
2Abnormal respiratory motile cilium morphology (HP:0005938)8.09802267
3Abnormal respiratory epithelium morphology (HP:0012253)8.09802267
4Rhinitis (HP:0012384)7.71205263
5Abnormal ciliary motility (HP:0012262)7.64726177
6Chronic bronchitis (HP:0004469)7.08122902
7Nasal polyposis (HP:0100582)6.05950365
8Infertility (HP:0000789)5.68887305
9Abnormality of the nasal mucosa (HP:0000433)4.91975674
10Action tremor (HP:0002345)4.51293905
11Bronchiectasis (HP:0002110)4.47026152
12Bronchitis (HP:0012387)4.43461459
13Nephronophthisis (HP:0000090)4.35416815
14Broad distal phalanx of finger (HP:0009836)4.11311148
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.08571275
16Degeneration of the lateral corticospinal tracts (HP:0002314)4.08571275
17Abnormal spermatogenesis (HP:0008669)4.05886770
18Impaired vibration sensation in the lower limbs (HP:0002166)3.93766584
19Atonic seizures (HP:0010819)3.92988522
20Oligodactyly (hands) (HP:0001180)3.89086312
21Abnormality of the lower motor neuron (HP:0002366)3.65891755
22Male infertility (HP:0003251)3.59441738
23Postural instability (HP:0002172)3.56065553
24Urinary bladder sphincter dysfunction (HP:0002839)3.51083717
25Progressive cerebellar ataxia (HP:0002073)3.45376777
26Myokymia (HP:0002411)3.44583379
27Azoospermia (HP:0000027)3.43725647
28Horizontal nystagmus (HP:0000666)3.41761700
29Recurrent sinusitis (HP:0011108)3.32132256
30Abnormality of the renal medulla (HP:0100957)3.25815186
31Abnormality of the corticospinal tract (HP:0002492)3.24795120
32Impaired vibratory sensation (HP:0002495)3.24776485
33Febrile seizures (HP:0002373)3.24182919
34Recurrent otitis media (HP:0000403)3.17667641
35Supranuclear gaze palsy (HP:0000605)3.12233616
36Genetic anticipation (HP:0003743)3.06292051
37Neurofibrillary tangles (HP:0002185)3.05375908
38Epileptic encephalopathy (HP:0200134)3.04915634
39Spastic gait (HP:0002064)3.02950752
40Absence seizures (HP:0002121)3.01383624
41Focal motor seizures (HP:0011153)2.93635269
42Hand muscle atrophy (HP:0009130)2.93295899
43Abnormality of midbrain morphology (HP:0002418)2.91623082
44Molar tooth sign on MRI (HP:0002419)2.91623082
45Gonadotropin excess (HP:0000837)2.88742946
46Shoulder girdle muscle weakness (HP:0003547)2.86990372
47Increased nuchal translucency (HP:0010880)2.85826195
48Urinary urgency (HP:0000012)2.85537730
49Abnormality of cochlea (HP:0000375)2.85263985
50Hyperthyroidism (HP:0000836)2.84507820
51Oligodactyly (HP:0012165)2.80876797
52Dysdiadochokinesis (HP:0002075)2.78027712
53Medial flaring of the eyebrow (HP:0010747)2.77044929
54Focal seizures (HP:0007359)2.76218396
55Metaphyseal cupping (HP:0003021)2.75967192
56Tubulointerstitial nephritis (HP:0001970)2.73761715
57Amyotrophic lateral sclerosis (HP:0007354)2.69379078
58Recurrent bronchitis (HP:0002837)2.67020497
59Fibular hypoplasia (HP:0003038)2.64886114
60Neuronal loss in central nervous system (HP:0002529)2.62147533
61Tubular atrophy (HP:0000092)2.60784718
62Ankle clonus (HP:0011448)2.56310096
63Bradykinesia (HP:0002067)2.54915863
64Short nail (HP:0001799)2.53746166
65Impulsivity (HP:0100710)2.51383489
66Status epilepticus (HP:0002133)2.51336261
67Ventricular fibrillation (HP:0001663)2.51277365
68Dysmetria (HP:0001310)2.49841079
69Poor eye contact (HP:0000817)2.49570305
70Large hands (HP:0001176)2.48130599
71Loss of speech (HP:0002371)2.43379052
72Volvulus (HP:0002580)2.40803738
73Abnormality of chromosome segregation (HP:0002916)2.39404966
74Resting tremor (HP:0002322)2.38337645
75Lower limb asymmetry (HP:0100559)2.37960006
76Depression (HP:0000716)2.34717772
77Tubulointerstitial abnormality (HP:0001969)2.33468515
78Facial cleft (HP:0002006)2.33415518
79Distal upper limb amyotrophy (HP:0007149)2.32273373
80Upper limb amyotrophy (HP:0009129)2.32273373
81Dialeptic seizures (HP:0011146)2.32012111
82Tongue fasciculations (HP:0001308)2.31087198
83Postaxial foot polydactyly (HP:0001830)2.29902470
84Microglossia (HP:0000171)2.29114648
85Supernumerary spleens (HP:0009799)2.28671363
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26721895
87Hyperpituitarism (HP:0010514)2.21861809
88Bundle branch block (HP:0011710)2.19081859
89Polyphagia (HP:0002591)2.18809366
90Degeneration of anterior horn cells (HP:0002398)2.18061280
91Abnormality of the anterior horn cell (HP:0006802)2.18061280
92Abnormal eating behavior (HP:0100738)2.17681056
93Menstrual irregularities (HP:0000858)2.14140899
94Bell-shaped thorax (HP:0001591)2.13399375
95Rectovaginal fistula (HP:0000143)2.12616605
96Rectal fistula (HP:0100590)2.12616605
97Congenital hepatic fibrosis (HP:0002612)2.10561427
98Gaze-evoked nystagmus (HP:0000640)2.09904005
99Upper motor neuron abnormality (HP:0002127)2.09864435
100Short ribs (HP:0000773)2.09792829
101Dysmetric saccades (HP:0000641)2.09770597
102Median cleft lip (HP:0000161)2.08766198
103Visual hallucinations (HP:0002367)2.08572079
10411 pairs of ribs (HP:0000878)2.08463248
105Morphological abnormality of the inner ear (HP:0011390)2.07787338
106Bowel incontinence (HP:0002607)2.07734980
107Pancreatic fibrosis (HP:0100732)2.07096311
108Muscle fibrillation (HP:0010546)2.05921516
109Slow saccadic eye movements (HP:0000514)2.00594810
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6801917
111Absent/shortened dynein arms (HP:0200106)11.5349500
112Dynein arm defect of respiratory motile cilia (HP:0012255)11.5349500
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98135572
114Truncal ataxia (HP:0002078)1.97816358
115Generalized tonic-clonic seizures (HP:0002069)1.97178061
116Septate vagina (HP:0001153)1.95119927
117Vaginal fistula (HP:0004320)1.94879135
118Abnormal large intestine physiology (HP:0012700)1.94485497
119Cerebral inclusion bodies (HP:0100314)1.93860851
120Lower limb muscle weakness (HP:0007340)1.93029805
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90340281
122Bifid scrotum (HP:0000048)1.90282386
123Upper limb muscle weakness (HP:0003484)1.90235770
124Absent frontal sinuses (HP:0002688)1.89514431
125Selective tooth agenesis (HP:0001592)1.88829255
126Scanning speech (HP:0002168)1.88024607
127Limb ataxia (HP:0002070)1.87182948
128Intellectual disability, profound (HP:0002187)1.87037084
129Oculomotor apraxia (HP:0000657)1.86826468
130Asymmetric growth (HP:0100555)1.85588593
131Tubulointerstitial fibrosis (HP:0005576)1.84934631
132Intestinal fistula (HP:0100819)1.84658455
133Stage 5 chronic kidney disease (HP:0003774)1.83639084
134Papilledema (HP:0001085)1.82684051
135Urinary incontinence (HP:0000020)1.82156086
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.79304377
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77529331
138Impaired proprioception (HP:0010831)1.77348183
139Abnormality of the renal cortex (HP:0011035)1.77028769
140Enlarged penis (HP:0000040)1.77024650
141Embryonal neoplasm (HP:0002898)1.76216574
142Macroorchidism (HP:0000053)1.74868176
143Abnormal drinking behavior (HP:0030082)1.74349078
144Polydipsia (HP:0001959)1.74349078
145Aplasia/Hypoplasia of the fibula (HP:0006492)1.73363151
146Renal dysplasia (HP:0000110)1.72541334
147Facial hemangioma (HP:0000329)1.72223504
148Abnormal social behavior (HP:0012433)1.72208924
149Impaired social interactions (HP:0000735)1.72208924
150Abnormality of lateral ventricle (HP:0030047)1.71324646
151Postaxial hand polydactyly (HP:0001162)1.71082823
152Choreoathetosis (HP:0001266)1.70807467
153Abnormality of ocular smooth pursuit (HP:0000617)1.67743976
154J-shaped sella turcica (HP:0002680)1.66937496
155Breast carcinoma (HP:0003002)1.65194679
156Congenital primary aphakia (HP:0007707)1.63129289
157Chronic sinusitis (HP:0011109)1.62964037
158Gait imbalance (HP:0002141)1.60224968
159Cystic liver disease (HP:0006706)1.58875778
160Nephroblastoma (Wilms tumor) (HP:0002667)1.57224371
161Heterotopia (HP:0002282)1.56611240
162Abnormality of permanent molar morphology (HP:0011071)1.55215374
163Abnormality of the dental root (HP:0006486)1.55215374
164Taurodontia (HP:0000679)1.55215374
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.53008893
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.52899456
167Abnormal biliary tract physiology (HP:0012439)1.50570299
168Bile duct proliferation (HP:0001408)1.50570299
169Abnormality of dentin (HP:0010299)1.49722535
170Short thorax (HP:0010306)1.48373058
171Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45995803
172Absent epiphyses (HP:0010577)1.45995803
173Abnormality of renal excretion (HP:0011036)1.45090220
174Embryonal renal neoplasm (HP:0011794)1.44370165
175Abnormality of molar (HP:0011077)1.44138014
176Abnormality of molar morphology (HP:0011070)1.44138014
177Sloping forehead (HP:0000340)1.43988561
178Abnormality of saccadic eye movements (HP:0000570)1.41180590
179Abnormality of the dental pulp (HP:0006479)1.38310053
180Poor coordination (HP:0002370)1.37200896
181Nephrogenic diabetes insipidus (HP:0009806)1.36826288
182True hermaphroditism (HP:0010459)1.36282572
183Deformed sella turcica (HP:0002681)1.34097391
184Spontaneous abortion (HP:0005268)1.33197758
185Pancreatic cysts (HP:0001737)1.31993643
186Occipital encephalocele (HP:0002085)1.31018747
187Chronic hepatic failure (HP:0100626)1.30939361
188Genital tract atresia (HP:0001827)1.29288367
189Optic nerve hypoplasia (HP:0000609)1.29025144
190Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.28814698
191Atrophy/Degeneration involving motor neurons (HP:0007373)1.27839594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.05573590
2PDK39.05573590
3CDK196.61670483
4PDK25.93708025
5EPHA43.70184168
6TESK13.51382197
7RIPK13.37486733
8PRKD32.65436952
9OXSR12.52662687
10NTRK32.32500221
11ICK2.32460099
12PTK2B2.24530785
13PNCK2.22266891
14PLK22.20520486
15WNK42.14454340
16DAPK22.07627007
17NEK22.07253845
18MET2.06106361
19STK392.01095234
20WEE11.96599911
21MAP3K91.95781988
22CDC71.89860490
23ARAF1.75551047
24PAK61.60588261
25MAP3K131.43466890
26TTK1.38264811
27CAMKK11.33181470
28BMX1.32954299
29CDK121.24884277
30TAOK21.23501168
31NEK91.21114367
32UHMK11.20073721
33STK381.16798582
34MINK11.14828240
35PRPF4B1.13738726
36ACVR1B1.10464292
37PASK1.09213140
38MAPK121.09158635
39MAP2K31.07361021
40PLK41.06597083
41BRSK21.05893834
42STK38L1.01908701
43RET1.01385791
44PRKD20.99153286
45CCNB10.96243420
46ATR0.94800937
47CHEK20.92654874
48KSR20.91168071
49DYRK30.90933733
50STK30.88429644
51MAP3K120.88429483
52CHEK10.88212649
53PRKCI0.87219606
54MAPK130.87082696
55PLK10.85136192
56FGR0.84510907
57TYRO30.83570735
58BUB10.83346142
59WNK10.82759841
60NTRK20.82532908
61CDK50.82105233
62DAPK10.81166177
63PDK10.80064121
64CDK140.79141718
65SIK20.76581008
66PTK20.75888044
67MAP2K40.74864449
68ABL20.73404325
69SGK10.72204824
70MAP3K20.71966552
71GRK50.67843187
72CAMK10.65705989
73LMTK20.63940059
74ATM0.62873606
75NTRK10.62198465
76DYRK1B0.61968233
77MARK10.60258238
78PINK10.58975757
79MAPK150.57291713
80DYRK1A0.56586488
81TAOK10.55460044
82SGK20.53457756
83MAP3K110.53270954
84KSR10.53137200
85EIF2AK10.51184636
86AKT20.50909928
87BRSK10.49091698
88IRAK10.48244421
89SGK4940.47526101
90SGK2230.47526101
91TESK20.46404705
92MAP3K10.45757812
93CASK0.43433633
94PRKCZ0.42589260
95CSF1R0.42374372
96ERN10.41161430
97NEK10.40643858
98MARK20.38797713
99SGK30.38702070
100CAMK2A0.37825845
101SRPK10.37671130
102MAP2K20.36771342
103MAP3K40.36600573
104CDK90.35062245
105CAMK2B0.34758021
106CSNK1G20.34039690
107MAP2K70.33266294
108PAK10.32931373
109PRKCH0.32592079
110MTOR0.32371111
111WNK30.32211796
112LIMK10.32137300
113CDK20.31849164
114PLK30.31319128
115AURKA0.29055255
116CDK70.27965464
117CDK10.27911670
118AURKB0.27475786
119CSNK2A20.26819953
120STK100.26363427
121EEF2K0.26028793
122MAP2K60.25339494
123CDK40.22323947
124CSNK2A10.22214320
125BRAF0.21169724
126RPS6KB10.20932217
127PDPK10.20650713
128MARK30.20443330
129PRKDC0.19811697
130NEK60.18696423
131PRKCG0.17603609
132BRD40.14992300
133AKT30.14694063
134CSNK1D0.14488132
135GSK3B0.13810380
136ZAP700.13807383
137BMPR1B0.12987636
138TSSK60.12467069
139STK160.11456372
140PRKAA10.11190850
141CSNK1E0.10799523
142EPHA20.10483771
143PAK40.10260836
144MAPK80.10076434
145PBK0.09778814
146CAMK1G0.08033237
147EIF2AK30.07649756
148CDK60.07560435
149MAPK100.07347551
150IRAK20.07039606
151PDGFRB0.06244718
152PAK20.05219688
153PIM10.04714837
154MAPK140.03620401
155STK40.03410270
156MAPK10.01951680
157RPS6KA10.01668368
158CDK150.01277345
159PRKACB0.01218681
160CDK30.00461795
161STK110.00405593
162CDK18-0.0103214
163CDK11A-0.0087198
164SCYL2-0.0083944

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.17617701
2Basal transcription factors_Homo sapiens_hsa030223.97471987
3Synaptic vesicle cycle_Homo sapiens_hsa047213.62457398
4Pyruvate metabolism_Homo sapiens_hsa006203.53130282
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.50651515
6Fanconi anemia pathway_Homo sapiens_hsa034603.39576220
7Pentose phosphate pathway_Homo sapiens_hsa000303.14691272
8Sulfur relay system_Homo sapiens_hsa041222.99771473
9Nicotine addiction_Homo sapiens_hsa050332.74949970
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72375268
11RNA transport_Homo sapiens_hsa030132.67480618
12Propanoate metabolism_Homo sapiens_hsa006402.57920922
13Selenocompound metabolism_Homo sapiens_hsa004502.42025941
14Oocyte meiosis_Homo sapiens_hsa041142.31160304
15Homologous recombination_Homo sapiens_hsa034402.25366163
16Glucagon signaling pathway_Homo sapiens_hsa049222.23507515
17Fatty acid biosynthesis_Homo sapiens_hsa000612.21311423
18Circadian entrainment_Homo sapiens_hsa047132.19227594
19mRNA surveillance pathway_Homo sapiens_hsa030152.09233533
20Linoleic acid metabolism_Homo sapiens_hsa005912.03192457
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01498588
22Glutamatergic synapse_Homo sapiens_hsa047241.89788272
23DNA replication_Homo sapiens_hsa030301.89151300
24Morphine addiction_Homo sapiens_hsa050321.89023865
25Huntingtons disease_Homo sapiens_hsa050161.80515404
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77899168
27Dorso-ventral axis formation_Homo sapiens_hsa043201.74337753
28Mismatch repair_Homo sapiens_hsa034301.68466426
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66101641
30Cell cycle_Homo sapiens_hsa041101.64434773
31GABAergic synapse_Homo sapiens_hsa047271.61530772
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.60751247
33Carbon metabolism_Homo sapiens_hsa012001.59792203
34Spliceosome_Homo sapiens_hsa030401.57771932
35Regulation of autophagy_Homo sapiens_hsa041401.57620520
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53806745
37Biosynthesis of amino acids_Homo sapiens_hsa012301.53199327
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53148294
39Glycerolipid metabolism_Homo sapiens_hsa005611.48016148
40Insulin secretion_Homo sapiens_hsa049111.45639833
41Proteasome_Homo sapiens_hsa030501.43233803
42Purine metabolism_Homo sapiens_hsa002301.40925458
43Dopaminergic synapse_Homo sapiens_hsa047281.37127706
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.33124648
45Circadian rhythm_Homo sapiens_hsa047101.30875669
46RNA degradation_Homo sapiens_hsa030181.29886685
47Nucleotide excision repair_Homo sapiens_hsa034201.25815168
48Cholinergic synapse_Homo sapiens_hsa047251.20772227
49Non-homologous end-joining_Homo sapiens_hsa034501.19987998
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18832099
51mTOR signaling pathway_Homo sapiens_hsa041501.18015316
52Parkinsons disease_Homo sapiens_hsa050121.17553164
53Base excision repair_Homo sapiens_hsa034101.17124778
54Renin-angiotensin system_Homo sapiens_hsa046141.17094729
55Fructose and mannose metabolism_Homo sapiens_hsa000511.14215950
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13890059
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13486499
58Gastric acid secretion_Homo sapiens_hsa049711.13367413
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.12941959
60Antigen processing and presentation_Homo sapiens_hsa046121.12213506
61Pyrimidine metabolism_Homo sapiens_hsa002401.10731371
62ErbB signaling pathway_Homo sapiens_hsa040121.04804577
63Olfactory transduction_Homo sapiens_hsa047401.03157703
64Taste transduction_Homo sapiens_hsa047421.03143230
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02979997
66Oxytocin signaling pathway_Homo sapiens_hsa049211.01371264
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01307837
68VEGF signaling pathway_Homo sapiens_hsa043701.00193786
69Prion diseases_Homo sapiens_hsa050200.93857403
70Fat digestion and absorption_Homo sapiens_hsa049750.92071720
71Phenylalanine metabolism_Homo sapiens_hsa003600.90937658
72Salivary secretion_Homo sapiens_hsa049700.89881637
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89200463
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88914942
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88310388
76Type II diabetes mellitus_Homo sapiens_hsa049300.87413270
77PPAR signaling pathway_Homo sapiens_hsa033200.86650088
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86010297
79Amphetamine addiction_Homo sapiens_hsa050310.85852462
80Systemic lupus erythematosus_Homo sapiens_hsa053220.84689615
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80548759
82Retinol metabolism_Homo sapiens_hsa008300.80368780
83Glioma_Homo sapiens_hsa052140.80065527
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79907998
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78759815
86Ether lipid metabolism_Homo sapiens_hsa005650.76686593
87Lysine degradation_Homo sapiens_hsa003100.76684148
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76637984
89Cocaine addiction_Homo sapiens_hsa050300.76285200
90cAMP signaling pathway_Homo sapiens_hsa040240.75352204
91Cardiac muscle contraction_Homo sapiens_hsa042600.72063334
92Glutathione metabolism_Homo sapiens_hsa004800.71891649
93Long-term depression_Homo sapiens_hsa047300.70161830
94Mineral absorption_Homo sapiens_hsa049780.70112791
95MAPK signaling pathway_Homo sapiens_hsa040100.70047276
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.69552612
97Folate biosynthesis_Homo sapiens_hsa007900.67873379
98GnRH signaling pathway_Homo sapiens_hsa049120.67756017
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64677685
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63296535
101Notch signaling pathway_Homo sapiens_hsa043300.63009360
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.61757529
103Epstein-Barr virus infection_Homo sapiens_hsa051690.61739924
104Serotonergic synapse_Homo sapiens_hsa047260.61368399
105Viral carcinogenesis_Homo sapiens_hsa052030.60031012
106Choline metabolism in cancer_Homo sapiens_hsa052310.59499488
107Renin secretion_Homo sapiens_hsa049240.58351961
108p53 signaling pathway_Homo sapiens_hsa041150.57420550
109Oxidative phosphorylation_Homo sapiens_hsa001900.54499538
110Gap junction_Homo sapiens_hsa045400.54433939
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.53829581
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53713068
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52768663
114Vibrio cholerae infection_Homo sapiens_hsa051100.52082807
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51616343
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49443932
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48670184
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45822649
119Fatty acid metabolism_Homo sapiens_hsa012120.44713987
120Fatty acid degradation_Homo sapiens_hsa000710.43062269
121Nitrogen metabolism_Homo sapiens_hsa009100.42538526
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39099188
123Metabolic pathways_Homo sapiens_hsa011000.38714049
124Legionellosis_Homo sapiens_hsa051340.37476481
125Alzheimers disease_Homo sapiens_hsa050100.37114479
126Chemical carcinogenesis_Homo sapiens_hsa052040.35755577
127ABC transporters_Homo sapiens_hsa020100.35209115
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34962423
129RNA polymerase_Homo sapiens_hsa030200.34959416
130beta-Alanine metabolism_Homo sapiens_hsa004100.34859000
131Arachidonic acid metabolism_Homo sapiens_hsa005900.34835220
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33934937
133Estrogen signaling pathway_Homo sapiens_hsa049150.33396212
134Long-term potentiation_Homo sapiens_hsa047200.32912397
135Phototransduction_Homo sapiens_hsa047440.32758562
136One carbon pool by folate_Homo sapiens_hsa006700.32266116
137Inositol phosphate metabolism_Homo sapiens_hsa005620.31528163
138AMPK signaling pathway_Homo sapiens_hsa041520.30704608
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.29785663
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29622180
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.29411106
142Ras signaling pathway_Homo sapiens_hsa040140.28079535
143HTLV-I infection_Homo sapiens_hsa051660.27583969
144Hedgehog signaling pathway_Homo sapiens_hsa043400.27369346
145N-Glycan biosynthesis_Homo sapiens_hsa005100.26387800
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26382081
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25212443
148Herpes simplex infection_Homo sapiens_hsa051680.23967449
149Endocytosis_Homo sapiens_hsa041440.22265706
150Alcoholism_Homo sapiens_hsa050340.20124551
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19326740
152Calcium signaling pathway_Homo sapiens_hsa040200.17256696
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16760604
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16015792
155Thyroid hormone synthesis_Homo sapiens_hsa049180.14427129
156Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11037890
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.10796009
158Tight junction_Homo sapiens_hsa045300.10637110
159Wnt signaling pathway_Homo sapiens_hsa043100.09109614
160Collecting duct acid secretion_Homo sapiens_hsa049660.05164521

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