SYCE1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.80680607
2acrosome assembly (GO:0001675)8.65433172
3sperm-egg recognition (GO:0035036)8.64744771
4binding of sperm to zona pellucida (GO:0007339)8.13486104
5multicellular organism reproduction (GO:0032504)8.03868115
6male meiosis (GO:0007140)7.96266266
7axonemal dynein complex assembly (GO:0070286)7.89709388
8acrosome reaction (GO:0007340)7.71815595
9cell-cell recognition (GO:0009988)7.69373993
10plasma membrane fusion (GO:0045026)7.52362016
11* synaptonemal complex organization (GO:0070193)7.49734719
12epithelial cilium movement (GO:0003351)7.49377784
13spermatid development (GO:0007286)7.48829154
14* synaptonemal complex assembly (GO:0007130)7.46866444
15DNA methylation involved in gamete generation (GO:0043046)7.45866844
16cell wall macromolecule catabolic process (GO:0016998)7.24164606
17cell wall macromolecule metabolic process (GO:0044036)7.24164606
18reproduction (GO:0000003)6.72655523
19motile cilium assembly (GO:0044458)6.51950359
20cilium movement (GO:0003341)6.28325287
21negative regulation of inclusion body assembly (GO:0090084)6.14067197
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.93607579
23viral transcription (GO:0019083)5.86158405
24regulation of cilium movement (GO:0003352)5.85491437
25male meiosis I (GO:0007141)5.77899690
26ribosomal small subunit assembly (GO:0000028)5.61488914
27translational termination (GO:0006415)5.61405143
28single fertilization (GO:0007338)5.58645259
29chaperone-mediated protein transport (GO:0072321)5.51006671
30establishment of protein localization to mitochondrial membrane (GO:0090151)5.43200031
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40889535
32meiotic nuclear division (GO:0007126)5.38537577
33spermatid nucleus differentiation (GO:0007289)5.30856960
34* chromosome organization involved in meiosis (GO:0070192)5.27767546
35meiosis I (GO:0007127)5.25489416
36ATP synthesis coupled proton transport (GO:0015986)5.22995205
37energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22995205
38protein complex biogenesis (GO:0070271)5.11873854
39sperm capacitation (GO:0048240)5.11693773
40fertilization (GO:0009566)5.07566512
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.06300534
42mitochondrial respiratory chain complex I assembly (GO:0032981)5.06300534
43NADH dehydrogenase complex assembly (GO:0010257)5.06300534
44spermatogenesis (GO:0007283)5.05128244
45male gamete generation (GO:0048232)5.03884197
46regulation of inclusion body assembly (GO:0090083)4.93034988
47sequestering of actin monomers (GO:0042989)4.91546375
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.89920854
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.85566631
50cotranslational protein targeting to membrane (GO:0006613)4.84086996
51ribosomal small subunit biogenesis (GO:0042274)4.81367256
52protein targeting to ER (GO:0045047)4.80579618
53mitochondrial respiratory chain complex assembly (GO:0033108)4.79578500
54translational elongation (GO:0006414)4.79341047
55maturation of SSU-rRNA (GO:0030490)4.73374495
56microtubule depolymerization (GO:0007019)4.70572668
57gamete generation (GO:0007276)4.61869842
58establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57655950
59protein localization to endoplasmic reticulum (GO:0070972)4.56517342
60viral life cycle (GO:0019058)4.51570323
61regulation of mitochondrial translation (GO:0070129)4.46135032
62protein neddylation (GO:0045116)4.43556113
63cellular protein complex disassembly (GO:0043624)4.37651378
64germ cell development (GO:0007281)4.35207095
65cellular process involved in reproduction in multicellular organism (GO:0022412)4.26829518
66chromosome condensation (GO:0030261)4.22163525
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.20861132
68meiotic cell cycle (GO:0051321)4.20416118
69pyrimidine nucleotide catabolic process (GO:0006244)4.16660188
70respiratory electron transport chain (GO:0022904)4.09096844
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06562035
72electron transport chain (GO:0022900)3.99893916
73ventricular system development (GO:0021591)3.97926642
74DNA packaging (GO:0006323)3.96720346
75cytochrome complex assembly (GO:0017004)3.95889549
76protein polyglutamylation (GO:0018095)3.94184033
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92823961
78positive regulation of mitochondrial fission (GO:0090141)3.92335385
79chaperone-mediated protein complex assembly (GO:0051131)3.92118573
80kinetochore assembly (GO:0051382)3.89909791
81protein complex disassembly (GO:0043241)3.85023476
82blastocyst development (GO:0001824)3.82087081
83behavioral response to nicotine (GO:0035095)3.81567717
84ribosomal large subunit biogenesis (GO:0042273)3.81174480
85seminiferous tubule development (GO:0072520)3.78406953
86respiratory chain complex IV assembly (GO:0008535)3.77497557
87base-excision repair, AP site formation (GO:0006285)3.76647045
88* meiotic cell cycle process (GO:1903046)3.69469167
89regulation of spindle checkpoint (GO:0090231)3.67746154
90chromatin remodeling at centromere (GO:0031055)3.67566276
91macromolecular complex disassembly (GO:0032984)3.67439970
92translational initiation (GO:0006413)3.67386124
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67125018
94tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67125018
95peptidyl-histidine modification (GO:0018202)3.64875045
96gene silencing by RNA (GO:0031047)3.62946877
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.60413862
98regulation of meiosis I (GO:0060631)3.56414892
99calcium ion-dependent exocytosis (GO:0017156)3.52871264
100multicellular organismal reproductive process (GO:0048609)3.52583142
101intracellular protein transmembrane import (GO:0044743)3.50699508
102cell recognition (GO:0008037)3.49118191
103organic cation transport (GO:0015695)3.46793040
104short-term memory (GO:0007614)3.39497653
105regulation of microtubule-based movement (GO:0060632)3.39052833
106metallo-sulfur cluster assembly (GO:0031163)3.38481530
107iron-sulfur cluster assembly (GO:0016226)3.38481530
108nucleoside diphosphate phosphorylation (GO:0006165)3.36523941
109negative regulation of organelle assembly (GO:1902116)3.36471885
110GTP biosynthetic process (GO:0006183)3.35126444
111protein targeting to membrane (GO:0006612)3.33388206
112protein localization to chromosome, centromeric region (GO:0071459)3.31758758
113histone exchange (GO:0043486)3.31593845
114cellular component biogenesis (GO:0044085)3.25802129
115microtubule severing (GO:0051013)3.22643155
116regulation of centriole replication (GO:0046599)3.22295219
117CENP-A containing nucleosome assembly (GO:0034080)3.21209641
118deoxyribonucleotide catabolic process (GO:0009264)3.21089241
119translation (GO:0006412)3.21039041
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18472536
121rRNA modification (GO:0000154)3.16510913
122ATP biosynthetic process (GO:0006754)3.15045968
123neuron fate determination (GO:0048664)3.13195709
124nuclear-transcribed mRNA catabolic process (GO:0000956)3.11726383
125substrate-independent telencephalic tangential migration (GO:0021826)3.11669701
126substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.11669701
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11611486
128intraciliary transport (GO:0042073)3.11097641
129protein refolding (GO:0042026)3.10900910
130mitotic sister chromatid cohesion (GO:0007064)3.08071785
131nonmotile primary cilium assembly (GO:0035058)3.07114917
132purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06836367
133UTP biosynthetic process (GO:0006228)3.06289481
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04066947
135guanosine-containing compound biosynthetic process (GO:1901070)3.03906376
136alditol metabolic process (GO:0019400)3.03560817
137monoubiquitinated protein deubiquitination (GO:0035520)3.00393140
138interferon-gamma secretion (GO:0072643)2.99607355
139protein targeting to mitochondrion (GO:0006626)2.98810259
140negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.98125932
141DNA damage response, detection of DNA damage (GO:0042769)2.97812097
142DNA alkylation (GO:0006305)2.97728223
143DNA methylation (GO:0006306)2.97728223
144establishment of protein localization to mitochondrion (GO:0072655)2.97361597
145negative regulation of telomere maintenance (GO:0032205)2.97027904
146preassembly of GPI anchor in ER membrane (GO:0016254)2.96902839
147mRNA catabolic process (GO:0006402)2.92991444
148GPI anchor metabolic process (GO:0006505)2.92780946
149water-soluble vitamin biosynthetic process (GO:0042364)2.92307795
150GPI anchor biosynthetic process (GO:0006506)2.91699058
151mitotic metaphase plate congression (GO:0007080)2.91004484
152hydrogen ion transmembrane transport (GO:1902600)2.88583664
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87787960
154C-terminal protein lipidation (GO:0006501)2.87105407
155nucleus organization (GO:0006997)2.87063084
156deoxyribose phosphate catabolic process (GO:0046386)2.83256690
157protein localization to mitochondrion (GO:0070585)2.82888086
158intracellular protein transmembrane transport (GO:0065002)2.79978409
159synapsis (GO:0007129)2.79882613
160protein complex localization (GO:0031503)2.79071140
161synaptic transmission, dopaminergic (GO:0001963)2.77301452
162genitalia morphogenesis (GO:0035112)2.76744239
163ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76411209
164mitotic sister chromatid segregation (GO:0000070)2.75498242
165negative regulation of DNA-templated transcription, elongation (GO:0032785)2.74833838
166RNA catabolic process (GO:0006401)2.73048675
167pseudouridine synthesis (GO:0001522)2.73013929
168microtubule polymerization or depolymerization (GO:0031109)2.72676973
169rRNA methylation (GO:0031167)2.71197475
170multicellular organismal development (GO:0007275)2.70074167
171transcription elongation from RNA polymerase III promoter (GO:0006385)2.69762755
172termination of RNA polymerase III transcription (GO:0006386)2.69762755
173tRNA processing (GO:0008033)2.67466822
174kinetochore organization (GO:0051383)2.67257739
175pyrimidine nucleobase catabolic process (GO:0006208)2.66121698
176UTP metabolic process (GO:0046051)2.65998191
177inner mitochondrial membrane organization (GO:0007007)2.65876885
178anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64955724
179regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64396197
180protein localization to cilium (GO:0061512)2.62146503
181gene silencing (GO:0016458)2.60750416
182attachment of spindle microtubules to kinetochore (GO:0008608)2.58939227
183otic vesicle formation (GO:0030916)2.58346654
184regulation of chromatin binding (GO:0035561)2.58144445
185single strand break repair (GO:0000012)2.55054667
186DNA replication-dependent nucleosome organization (GO:0034723)2.54845064
187DNA replication-dependent nucleosome assembly (GO:0006335)2.54845064
188positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53972836
189regulation of chromosome segregation (GO:0051983)2.53865767
190polyol catabolic process (GO:0046174)2.49298673
191glycerol ether metabolic process (GO:0006662)2.48793680
192nuclear division (GO:0000280)2.48352534
193negative regulation of proteasomal protein catabolic process (GO:1901799)2.48306527
194cilium or flagellum-dependent cell motility (GO:0001539)10.8889340
195piRNA metabolic process (GO:0034587)10.6354108
196fusion of sperm to egg plasma membrane (GO:0007342)10.0364561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79678258
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39022409
3EZH2_22144423_ChIP-Seq_EOC_Human3.29361008
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20151534
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99416484
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.88688765
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.78407054
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61473389
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57432721
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.46167751
11* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.40799997
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35365183
13TTF2_22483619_ChIP-Seq_HELA_Human2.28363019
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.17714810
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07418262
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.05256441
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03318188
18MYC_18940864_ChIP-ChIP_HL60_Human2.00550185
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.00313526
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6140871
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93431587
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93367643
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91111694
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87254804
25AR_21909140_ChIP-Seq_LNCAP_Human1.86879501
26IRF1_19129219_ChIP-ChIP_H3396_Human1.86185300
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86019145
28VDR_22108803_ChIP-Seq_LS180_Human1.84816353
29ELK1_19687146_ChIP-ChIP_HELA_Human1.83696872
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79155762
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.75989660
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72677007
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67732617
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.67677113
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.66965483
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65171227
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.58766784
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57654789
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50351293
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49023144
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47145492
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46749120
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.46039602
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43195889
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42311442
46GATA3_21867929_ChIP-Seq_CD8_Mouse1.41680935
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41420736
48ZNF274_21170338_ChIP-Seq_K562_Hela1.38663198
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36869116
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36718130
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36389477
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36070979
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33639696
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33083625
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.33036498
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32807356
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.31604824
58FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29447197
59DCP1A_22483619_ChIP-Seq_HELA_Human1.29108752
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28327238
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28262792
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27365805
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24440530
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.20183473
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.19248824
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17609513
67VDR_23849224_ChIP-Seq_CD4+_Human1.17430385
68BCL6_27268052_Chip-Seq_Bcells_Human1.17222229
69GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.15625620
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15188486
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.14970871
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14520357
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13593770
74P53_21459846_ChIP-Seq_SAOS-2_Human1.13314327
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12849333
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.12453271
77IGF1R_20145208_ChIP-Seq_DFB_Human1.12235604
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10643750
79STAT1_17558387_ChIP-Seq_HELA_Human1.10514431
80KDM5A_27292631_Chip-Seq_BREAST_Human1.10288067
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10021719
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08439490
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.08066810
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07921722
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07871064
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07834104
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07438945
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07255906
89STAT1_20625510_ChIP-Seq_HELA_Human1.07179597
90FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06822212
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.06583277
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05998193
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.05874498
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04635483
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04192952
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03420431
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03191265
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.03056281
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02889135
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02609670
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02323980
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02070783
103RNF2_27304074_Chip-Seq_NSC_Mouse1.01935604
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99808018
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98901213
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98707868
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.98628575
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98064883
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.97808470
110RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97101204
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97050877
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.95721777
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95662002
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.95531763
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95257496
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95011104
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95010628
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.94851401
119WDR5_24793694_ChIP-Seq_LNCAP_Human0.94679057
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94151925
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93683413
122GABP_19822575_ChIP-Seq_HepG2_Human0.92344384
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91775250
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90429782
125CIITA_25753668_ChIP-Seq_RAJI_Human0.89715072
126ZNF263_19887448_ChIP-Seq_K562_Human0.89461957
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88753422
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.88079718
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88062082
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87349307
131SOX2_21211035_ChIP-Seq_LN229_Human0.87116929
132FLI1_21867929_ChIP-Seq_CD8_Mouse0.86919175
133XRN2_22483619_ChIP-Seq_HELA_Human0.86904633
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86739566
135* ERA_21632823_ChIP-Seq_H3396_Human0.86693038
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86581050
137P68_20966046_ChIP-Seq_HELA_Human0.86478424
138LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85917091
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85724932
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84522409
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84010543
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82890790
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.82583582
144CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80639990
145SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80011402
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79212715
147PHF8_20622854_ChIP-Seq_HELA_Human0.78373177
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77351068
149CTCF_26484167_Chip-Seq_Bcells_Mouse0.77199491
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76685295
151FOXP3_21729870_ChIP-Seq_TREG_Human0.76423388
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76000652
153TP53_22573176_ChIP-Seq_HFKS_Human0.74200480
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.74193177
155REST_21632747_ChIP-Seq_MESCs_Mouse0.74178435
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74161447
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74049383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.56618341
2MP0003698_abnormal_male_reproductive5.15931369
3MP0001929_abnormal_gametogenesis5.01003667
4MP0006292_abnormal_olfactory_placode4.86609369
5MP0002210_abnormal_sex_determination3.73287320
6MP0009379_abnormal_foot_pigmentation3.60049870
7MP0008789_abnormal_olfactory_epithelium3.34876385
8MP0003693_abnormal_embryo_hatching3.31731802
9MP0001145_abnormal_male_reproductive3.17286220
10MP0003122_maternal_imprinting3.06909627
11MP0003950_abnormal_plasma_membrane3.05816537
12MP0002161_abnormal_fertility/fecundity2.86521359
13MP0000653_abnormal_sex_gland2.73164016
14MP0005394_taste/olfaction_phenotype2.67648757
15MP0005499_abnormal_olfactory_system2.67648757
16MP0003111_abnormal_nucleus_morphology2.63012276
17MP0006276_abnormal_autonomic_nervous2.40480108
18MP0003880_abnormal_central_pattern2.35559034
19MP0003786_premature_aging2.32372243
20MP0000049_abnormal_middle_ear2.27710267
21MP0002160_abnormal_reproductive_system2.21130274
22MP0002736_abnormal_nociception_after2.16314784
23MP0005084_abnormal_gallbladder_morpholo2.11256815
24MP0010030_abnormal_orbit_morphology2.10552482
25MP0004957_abnormal_blastocyst_morpholog2.10401369
26MP0001968_abnormal_touch/_nociception2.01642314
27MP0010094_abnormal_chromosome_stability2.01491037
28MP0003718_maternal_effect2.00271024
29MP0005410_abnormal_fertilization11.7798991
30MP0003121_genomic_imprinting1.99970367
31MP0008995_early_reproductive_senescence1.97320772
32MP0003077_abnormal_cell_cycle1.96164543
33MP0002653_abnormal_ependyma_morphology1.95024972
34MP0001905_abnormal_dopamine_level1.78346556
35MP0002234_abnormal_pharynx_morphology1.75523995
36MP0008058_abnormal_DNA_repair1.73460589
37MP0008007_abnormal_cellular_replicative1.66209870
38MP0001293_anophthalmia1.64277595
39MP0004133_heterotaxia1.64228305
40MP0005670_abnormal_white_adipose1.64167516
41MP0001984_abnormal_olfaction1.63613131
42MP0008932_abnormal_embryonic_tissue1.62426258
43MP0003186_abnormal_redox_activity1.52752287
44MP0003806_abnormal_nucleotide_metabolis1.44688636
45MP0004147_increased_porphyrin_level1.38492995
46MP0002822_catalepsy1.37453390
47MP0000778_abnormal_nervous_system1.35636520
48MP0003646_muscle_fatigue1.34768137
49MP0002735_abnormal_chemical_nociception1.32817159
50MP0008260_abnormal_autophagy1.29524266
51MP0000026_abnormal_inner_ear1.28162188
52MP0004142_abnormal_muscle_tone1.27795325
53MP0005389_reproductive_system_phenotype1.26851599
54MP0002557_abnormal_social/conspecific_i1.26592321
55MP0005646_abnormal_pituitary_gland1.23296879
56MP0002938_white_spotting1.22725911
57MP0003941_abnormal_skin_development1.22342467
58MP0008057_abnormal_DNA_replication1.21656199
59MP0005253_abnormal_eye_physiology1.19226895
60MP0001730_embryonic_growth_arrest1.18703241
61MP0000631_abnormal_neuroendocrine_gland1.17357048
62MP0006072_abnormal_retinal_apoptosis1.15677657
63MP0002928_abnormal_bile_duct1.14019700
64MP0009046_muscle_twitch1.12658508
65MP0000516_abnormal_urinary_system1.11684167
66MP0005367_renal/urinary_system_phenotyp1.11684167
67MP0002733_abnormal_thermal_nociception1.11682978
68MP0009840_abnormal_foam_cell1.08303316
69MP0003878_abnormal_ear_physiology1.06760638
70MP0005377_hearing/vestibular/ear_phenot1.06760638
71MP0005167_abnormal_blood-brain_barrier1.06673102
72MP0002233_abnormal_nose_morphology1.05634915
73MP0003123_paternal_imprinting1.03925365
74MP0002572_abnormal_emotion/affect_behav1.03479824
75MP0003937_abnormal_limbs/digits/tail_de1.02629120
76MP0000537_abnormal_urethra_morphology1.01846377
77MP0005623_abnormal_meninges_morphology1.01731191
78MP0002752_abnormal_somatic_nervous0.99931848
79MP0002184_abnormal_innervation0.97800748
80MP0001727_abnormal_embryo_implantation0.97687848
81MP0005391_vision/eye_phenotype0.97512339
82MP0002638_abnormal_pupillary_reflex0.96210289
83MP0003567_abnormal_fetal_cardiomyocyte0.95592577
84MP0006036_abnormal_mitochondrial_physio0.94671549
85MP0001661_extended_life_span0.91705764
86MP0001970_abnormal_pain_threshold0.91058883
87MP0005195_abnormal_posterior_eye0.91007220
88MP0001963_abnormal_hearing_physiology0.90064587
89MP0000358_abnormal_cell_content/0.89169946
90MP0009745_abnormal_behavioral_response0.89034502
91MP0002697_abnormal_eye_size0.88739890
92MP0006035_abnormal_mitochondrial_morpho0.87238391
93MP0001286_abnormal_eye_development0.86460928
94MP0005409_darkened_coat_color0.85659298
95MP0008872_abnormal_physiological_respon0.85459050
96MP0002734_abnormal_mechanical_nocicepti0.83956877
97MP0004019_abnormal_vitamin_homeostasis0.81299866
98MP0003315_abnormal_perineum_morphology0.79254457
99MP0005058_abnormal_lysosome_morphology0.77949607
100MP0005395_other_phenotype0.77565261
101MP0005551_abnormal_eye_electrophysiolog0.75229898
102MP0001697_abnormal_embryo_size0.73344670
103MP0002272_abnormal_nervous_system0.71598172
104MP0003938_abnormal_ear_development0.70994025
105MP0003115_abnormal_respiratory_system0.70853244
106MP0002152_abnormal_brain_morphology0.70788024
107MP0005451_abnormal_body_composition0.70739473
108MP0001919_abnormal_reproductive_system0.70289944
109MP0009765_abnormal_xenobiotic_induced0.69511349
110MP0001672_abnormal_embryogenesis/_devel0.68837658
111MP0005380_embryogenesis_phenotype0.68837658
112MP0009697_abnormal_copulation0.67353472
113MP0002882_abnormal_neuron_morphology0.66330053
114MP0002092_abnormal_eye_morphology0.65687198
115MP0002080_prenatal_lethality0.65585118
116MP0003755_abnormal_palate_morphology0.65084055
117MP0001502_abnormal_circadian_rhythm0.65083712
118MP0003634_abnormal_glial_cell0.63946066
119MP0001756_abnormal_urination0.63157649
120MP0004043_abnormal_pH_regulation0.63040338
121MP0002282_abnormal_trachea_morphology0.61675198
122MP0003699_abnormal_female_reproductive0.61502371
123MP0002163_abnormal_gland_morphology0.60759156
124MP0004742_abnormal_vestibular_system0.60373883
125MP0003984_embryonic_growth_retardation0.60311349
126MP0000647_abnormal_sebaceous_gland0.58672668
127MP0005647_abnormal_sex_gland0.57436818
128MP0003329_amyloid_beta_deposits0.56797241
129MP0001440_abnormal_grooming_behavior0.56559338
130MP0001765_abnormal_ion_homeostasis0.56172238
131MP0002088_abnormal_embryonic_growth/wei0.55738712
132MP0002085_abnormal_embryonic_tissue0.55344447
133MP0000313_abnormal_cell_death0.53322454
134MP0000350_abnormal_cell_proliferation0.50915732
135MP0004084_abnormal_cardiac_muscle0.47163730
136MP0001348_abnormal_lacrimal_gland0.46490192
137MP0001119_abnormal_female_reproductive0.44232993
138MP0001764_abnormal_homeostasis0.43450326
139MP0004036_abnormal_muscle_relaxation0.43127651
140MP0003936_abnormal_reproductive_system0.42420068
141MP0003011_delayed_dark_adaptation0.42200799
142MP0002837_dystrophic_cardiac_calcinosis0.42106546
143MP0002269_muscular_atrophy0.41591326
144MP0002084_abnormal_developmental_patter0.41226734
145MP0003861_abnormal_nervous_system0.40675001
146MP0005423_abnormal_somatic_nervous0.40512035
147MP0005332_abnormal_amino_acid0.40475134
148MP0001485_abnormal_pinna_reflex0.39995141
149MP0000920_abnormal_myelination0.38986078
150MP0003221_abnormal_cardiomyocyte_apopto0.38913310
151MP0004885_abnormal_endolymph0.38534603
152MP0009672_abnormal_birth_weight0.37000469
153MP0004233_abnormal_muscle_weight0.36597231
154MP0005408_hypopigmentation0.35665731
155MP0005397_hematopoietic_system_phenotyp0.35492918
156MP0001545_abnormal_hematopoietic_system0.35492918
157MP0005636_abnormal_mineral_homeostasis0.33847816
158MP0000955_abnormal_spinal_cord0.33596990
159MP0003890_abnormal_embryonic-extraembry0.31979239
160MP0003632_abnormal_nervous_system0.31153019
161MP0010307_abnormal_tumor_latency0.30470994
162MP0003787_abnormal_imprinting0.30440314
163MP0005379_endocrine/exocrine_gland_phen0.30048298
164MP0001529_abnormal_vocalization0.29009671
165MP0000001_mammalian_phenotype0.28877602
166MP0002169_no_abnormal_phenotype0.28722390
167MP0005075_abnormal_melanosome_morpholog0.28637662

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.02303341
2Abnormal respiratory motile cilium morphology (HP:0005938)7.59094368
3Abnormal respiratory epithelium morphology (HP:0012253)7.59094368
4Rhinitis (HP:0012384)6.86643797
5Chronic bronchitis (HP:0004469)6.45732445
6Abnormal ciliary motility (HP:0012262)6.19761189
7Infertility (HP:0000789)6.17825397
8Reticulocytopenia (HP:0001896)5.20539211
9Acute necrotizing encephalopathy (HP:0006965)5.18064016
10Nasal polyposis (HP:0100582)5.15991116
11Abnormal mitochondria in muscle tissue (HP:0008316)4.76441457
12Mitochondrial inheritance (HP:0001427)4.64034434
13Hepatocellular necrosis (HP:0001404)4.49139292
14Abnormal spermatogenesis (HP:0008669)4.48681339
15Acute encephalopathy (HP:0006846)4.43398412
16Progressive macrocephaly (HP:0004481)4.20727547
17Abnormality of the nasal mucosa (HP:0000433)4.02848985
18Increased CSF lactate (HP:0002490)3.99633380
19Male infertility (HP:0003251)3.83679753
20Bronchiectasis (HP:0002110)3.82632413
21Hepatic necrosis (HP:0002605)3.79210567
22Abnormality of cells of the erythroid lineage (HP:0012130)3.77907983
23Azoospermia (HP:0000027)3.74272765
24Bronchitis (HP:0012387)3.70163668
25Abnormal number of erythroid precursors (HP:0012131)3.60567007
26Nephronophthisis (HP:0000090)3.44262076
27Impulsivity (HP:0100710)3.44209390
28Renal Fanconi syndrome (HP:0001994)3.39676753
29Increased hepatocellular lipid droplets (HP:0006565)3.36353838
30True hermaphroditism (HP:0010459)3.23263692
31Lipid accumulation in hepatocytes (HP:0006561)3.20403751
32Gonadotropin excess (HP:0000837)3.18855570
33Cerebral edema (HP:0002181)3.18479496
34Pancreatic cysts (HP:0001737)3.10388345
35Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03771781
36Recurrent otitis media (HP:0000403)2.95130004
37Pendular nystagmus (HP:0012043)2.93977162
38Myokymia (HP:0002411)2.77315113
39Recurrent sinusitis (HP:0011108)2.77118463
40Sensory axonal neuropathy (HP:0003390)2.76726590
413-Methylglutaconic aciduria (HP:0003535)2.73474270
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71612354
43Increased intramyocellular lipid droplets (HP:0012240)2.71495701
44Facial cleft (HP:0002006)2.66073600
45Abnormality of the anterior horn cell (HP:0006802)2.65611542
46Degeneration of anterior horn cells (HP:0002398)2.65611542
47Lactic acidosis (HP:0003128)2.65420534
48Sclerocornea (HP:0000647)2.61721402
49Macrocytic anemia (HP:0001972)2.60412218
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59877478
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59877478
52Abnormality of the lower motor neuron (HP:0002366)2.59808788
53Respiratory failure (HP:0002878)2.57798841
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56979694
55Congenital primary aphakia (HP:0007707)2.55831370
56Optic disc pallor (HP:0000543)2.55686485
57Gait imbalance (HP:0002141)2.53854111
58Exercise intolerance (HP:0003546)2.51621674
59Abnormality of the renal medulla (HP:0100957)2.49743180
60Amyotrophic lateral sclerosis (HP:0007354)2.48426108
61Increased muscle lipid content (HP:0009058)2.44440680
62Rib fusion (HP:0000902)2.43246138
63Abnormality of midbrain morphology (HP:0002418)2.42905759
64Molar tooth sign on MRI (HP:0002419)2.42905759
65Retinal dysplasia (HP:0007973)2.39500162
66Testicular atrophy (HP:0000029)2.37754529
67Brushfield spots (HP:0001088)2.37113928
68Anencephaly (HP:0002323)2.35535609
69Nephrogenic diabetes insipidus (HP:0009806)2.34231458
70Cerebral hypomyelination (HP:0006808)2.34123764
71Increased serum lactate (HP:0002151)2.23918377
72Pallor (HP:0000980)2.23710115
73Methylmalonic aciduria (HP:0012120)2.21935332
74Abnormality of renal resorption (HP:0011038)2.21093231
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.16953424
76Absent epiphyses (HP:0010577)2.16953424
77Fibular hypoplasia (HP:0003038)2.15988739
78Cystic liver disease (HP:0006706)2.13955871
79Cleft eyelid (HP:0000625)2.10764607
80Exertional dyspnea (HP:0002875)2.08796175
81Secondary amenorrhea (HP:0000869)2.07381424
82Abnormality of reticulocytes (HP:0004312)2.03341593
83Impaired proprioception (HP:0010831)2.02941322
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02416707
85Delayed CNS myelination (HP:0002188)2.02275188
86Areflexia of lower limbs (HP:0002522)2.02106218
87Tubular atrophy (HP:0000092)2.01618460
88Type 2 muscle fiber atrophy (HP:0003554)2.00562908
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7216192
90Dynein arm defect of respiratory motile cilia (HP:0012255)10.9058986
91Absent/shortened dynein arms (HP:0200106)10.9058986
92Holoprosencephaly (HP:0001360)1.99973811
93Microretrognathia (HP:0000308)1.99942456
94Medial flaring of the eyebrow (HP:0010747)1.99882802
95Oligodactyly (hands) (HP:0001180)1.98189933
96Colon cancer (HP:0003003)1.96296790
97Leukodystrophy (HP:0002415)1.94508857
98Spastic tetraparesis (HP:0001285)1.93899639
99Adrenal hypoplasia (HP:0000835)1.92488275
100Male pseudohermaphroditism (HP:0000037)1.92210626
101Vaginal atresia (HP:0000148)1.90178246
102Horseshoe kidney (HP:0000085)1.89750915
103Short tibia (HP:0005736)1.89611790
104Chromsome breakage (HP:0040012)1.88782971
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88685333
106Premature ovarian failure (HP:0008209)1.88019670
107Genital tract atresia (HP:0001827)1.86745685
108Type II lissencephaly (HP:0007260)1.86725373
109Recurrent bronchitis (HP:0002837)1.86451151
110Muscle fiber atrophy (HP:0100295)1.85805717
111Agitation (HP:0000713)1.85244412
112Occipital encephalocele (HP:0002085)1.83360753
113Lethargy (HP:0001254)1.83083262
114Methylmalonic acidemia (HP:0002912)1.81506236
115Dysautonomia (HP:0002459)1.81199045
116Rough bone trabeculation (HP:0100670)1.80822517
117Tubulointerstitial nephritis (HP:0001970)1.79795821
118Type I transferrin isoform profile (HP:0003642)1.79680165
119Breast hypoplasia (HP:0003187)1.79359998
120Abnormality of urine glucose concentration (HP:0011016)1.79287854
121Glycosuria (HP:0003076)1.79287854
122Hypoplasia of the brainstem (HP:0002365)1.79032218
123Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79032218
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.77716290
125Septo-optic dysplasia (HP:0100842)1.77710079
126Congenital, generalized hypertrichosis (HP:0004540)1.77560379
127Emotional lability (HP:0000712)1.77040412
128Optic nerve coloboma (HP:0000588)1.76670762
129Postaxial hand polydactyly (HP:0001162)1.76081980
130Selective tooth agenesis (HP:0001592)1.76080495
131Depressed nasal ridge (HP:0000457)1.75342552
132Absent thumb (HP:0009777)1.75129110
133Abnormality of DNA repair (HP:0003254)1.75051359
134Respiratory difficulties (HP:0002880)1.74235430
135X-linked dominant inheritance (HP:0001423)1.73585936
136Abnormality of the clitoris (HP:0000056)1.73366084
137Tubulointerstitial abnormality (HP:0001969)1.72443385
138Cutaneous melanoma (HP:0012056)1.71470405
139Carpal bone hypoplasia (HP:0001498)1.70788992
140Short ribs (HP:0000773)1.70595928
141Ureteral duplication (HP:0000073)1.70594037
142Panhypogammaglobulinemia (HP:0003139)1.70588226
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.70511980
144Papillary thyroid carcinoma (HP:0002895)1.70296223
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.68641059
146Microglossia (HP:0000171)1.67959338
147CNS demyelination (HP:0007305)1.67574759
148Dicarboxylic aciduria (HP:0003215)1.67486757
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67486757
150Clitoromegaly (HP:0000057)1.66636173
151Supernumerary spleens (HP:0009799)1.65495828
152Oculomotor apraxia (HP:0000657)1.63171234
153Personality changes (HP:0000751)1.61747283
154Delusions (HP:0000746)1.61501343
155Bile duct proliferation (HP:0001408)1.61469905
156Abnormal biliary tract physiology (HP:0012439)1.61469905
157Abnormality of permanent molar morphology (HP:0011071)1.59290809
158Abnormality of the dental root (HP:0006486)1.59290809
159Taurodontia (HP:0000679)1.59290809
160Pancreatic fibrosis (HP:0100732)1.59026801
161Postaxial foot polydactyly (HP:0001830)1.58230677
162Dyschromatopsia (HP:0007641)1.57383858
163Hyperglycinemia (HP:0002154)1.56645434
164Bell-shaped thorax (HP:0001591)1.55857025
165Aplasia/Hypoplasia of the fibula (HP:0006492)1.55461146
166Breast carcinoma (HP:0003002)1.54479030
167Malnutrition (HP:0004395)1.53681842
168Absent eyebrow (HP:0002223)1.51437860
169Atrophy/Degeneration involving motor neurons (HP:0007373)1.51065902
170Broad distal phalanx of finger (HP:0009836)1.49727450
171Tubulointerstitial fibrosis (HP:0005576)1.49223907
172Double outlet right ventricle (HP:0001719)1.49048559
173Congenital malformation of the right heart (HP:0011723)1.49048559
174Bifid tongue (HP:0010297)1.48692221
175Hypoplasia of the radius (HP:0002984)1.48207172
176Abnormality of the umbilical cord (HP:0010881)1.48021613
177Difficulty climbing stairs (HP:0003551)1.47739026
178Oligodactyly (HP:0012165)1.45767718
179CNS hypomyelination (HP:0003429)1.44962994
180Abnormality of molar (HP:0011077)1.42633387
181Abnormality of molar morphology (HP:0011070)1.42633387
182Abnormality of the labia minora (HP:0012880)1.41349243
183Ileus (HP:0002595)1.41146659
184Abnormal trabecular bone morphology (HP:0100671)1.41035762
185Abnormality of the dental pulp (HP:0006479)1.39525217
186Microvesicular hepatic steatosis (HP:0001414)1.39300465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.54394987
2PDK47.54394987
3PDK24.81245157
4VRK24.03481810
5TIE13.94093388
6BUB13.61870351
7MAP4K23.55524801
8PNCK3.49438614
9WEE13.14216053
10ZAK3.12022631
11TESK13.07141638
12BCKDK3.04800009
13NEK22.73390061
14PRKD32.51235434
15STK392.44663477
16CCNB12.15855912
17MAP2K72.02936139
18NUAK11.99416055
19ICK1.98512660
20EIF2AK11.95465117
21TRIM281.92716537
22WNK41.88529369
23CSNK1G21.88487087
24CSNK1A1L1.77251156
25MAP3K41.75425921
26ARAF1.66938658
27EPHB21.66166938
28RPS6KA41.50982562
29GRK11.38204079
30EIF2AK31.33535990
31DYRK31.29891803
32TTK1.29640619
33PLK41.28019581
34STK161.25094668
35PTK2B1.23873126
36LIMK11.22566440
37EPHA21.18355878
38CASK1.16172335
39CDK81.15300952
40BMPR1B1.14679580
41MINK11.12611232
42PASK1.05932471
43PLK11.04928937
44BRAF1.00642816
45MAP3K110.98714917
46CDC70.96912818
47STK380.91845332
48SRPK10.89626919
49DYRK1B0.89290233
50ADRBK20.88116172
51CDK90.86685495
52TNK20.84377148
53BRSK20.81228584
54TNIK0.80483171
55TSSK60.80141018
56CHEK20.78919770
57WNK10.77968143
58NTRK20.77220117
59PDK10.75658064
60PLK30.74505914
61MAP2K40.71620406
62STK30.71393079
63INSRR0.69341064
64PINK10.69221515
65NME10.66696322
66EPHA40.66086453
67CHEK10.65811125
68BCR0.65508544
69AURKB0.65375392
70DAPK10.64086248
71PAK10.63725663
72PIM20.63564640
73AURKA0.62107718
74MARK20.60935549
75DYRK20.57646335
76WNK30.57067807
77TAF10.55215348
78OXSR10.55080037
79NEK10.54940879
80DAPK30.54550773
81BRSK10.52896244
82CSNK1A10.50911331
83MAP3K80.49662270
84IRAK20.49489354
85PDPK10.49114831
86MAPK150.48474516
87LRRK20.48284786
88PRKCG0.47619635
89MAPK130.47465016
90AKT30.47389805
91TESK20.47252039
92PLK20.44678309
93ATR0.42727494
94MST40.42722880
95CDK190.42003603
96RPS6KA50.39926209
97MAP3K90.39429529
98FLT30.39103072
99SIK30.38895523
100CAMK2A0.37770711
101GSK3A0.37163044
102STK38L0.36923510
103TYRO30.35428673
104STK110.34913265
105CSNK2A10.34496854
106NME20.34408185
107CDK70.34151803
108PRKACA0.33610405
109CDK40.32246007
110EIF2AK20.31437440
111CAMK2B0.31161024
112VRK10.31159468
113MAPKAPK30.30814467
114TGFBR10.30445272
115MARK30.30196440
116CDK20.29656528
117ATM0.29471169
118CDK10.28756970
119KDR0.28257973
120AKT20.27045317
121CSNK1G10.26319094
122CSNK1E0.25561402
123MAPK40.24772810
124PBK0.23564056
125MKNK20.23311940
126PAK40.23017757
127IRAK10.22896220
128CSNK2A20.22357294
129SGK30.22130682
130CSNK1G30.21198378
131MTOR0.21196374
132CDK150.20236560
133CAMK2G0.19464772
134CDK140.18119766
135MUSK0.17357942
136MKNK10.16531661
137ABL20.16520093
138PKN10.16369425
139CDK180.15995811
140UHMK10.14757912
141CDK11A0.14486939
142PIM10.13704322
143TLK10.12639365
144MARK10.12477000
145CDK30.12456599
146MAPK80.12358003
147PRKCI0.12327940
148GSK3B0.11911314

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.95278983
2Proteasome_Homo sapiens_hsa030504.62065609
3RNA polymerase_Homo sapiens_hsa030203.25563042
4Basal transcription factors_Homo sapiens_hsa030223.25503026
5RNA transport_Homo sapiens_hsa030133.07061950
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02533596
7Pentose phosphate pathway_Homo sapiens_hsa000302.61328787
8Sulfur relay system_Homo sapiens_hsa041222.48182987
9Oocyte meiosis_Homo sapiens_hsa041142.27508290
10Pyrimidine metabolism_Homo sapiens_hsa002402.24985091
11Huntingtons disease_Homo sapiens_hsa050162.09259104
12Spliceosome_Homo sapiens_hsa030402.07124320
13Linoleic acid metabolism_Homo sapiens_hsa005912.00823744
14Pyruvate metabolism_Homo sapiens_hsa006201.95650905
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89681222
16Fanconi anemia pathway_Homo sapiens_hsa034601.89218794
17Homologous recombination_Homo sapiens_hsa034401.88113023
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87671156
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.87527699
20Regulation of autophagy_Homo sapiens_hsa041401.86244502
21Purine metabolism_Homo sapiens_hsa002301.79587385
22Ribosome_Homo sapiens_hsa030101.66596361
23Cell cycle_Homo sapiens_hsa041101.62548417
24Peroxisome_Homo sapiens_hsa041461.54717781
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.52041290
26mRNA surveillance pathway_Homo sapiens_hsa030151.48826743
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.48468710
28Selenocompound metabolism_Homo sapiens_hsa004501.43443168
29Fatty acid biosynthesis_Homo sapiens_hsa000611.41737162
30Propanoate metabolism_Homo sapiens_hsa006401.40224352
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32794578
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28134718
33Fructose and mannose metabolism_Homo sapiens_hsa000511.26127712
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23594807
35Dorso-ventral axis formation_Homo sapiens_hsa043201.23111586
36Ether lipid metabolism_Homo sapiens_hsa005651.21422273
37Protein export_Homo sapiens_hsa030601.19743519
38Glucagon signaling pathway_Homo sapiens_hsa049221.18843350
39Glycerolipid metabolism_Homo sapiens_hsa005611.16879331
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15419645
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11291301
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10212440
43Epstein-Barr virus infection_Homo sapiens_hsa051691.05834905
44Oxidative phosphorylation_Homo sapiens_hsa001901.04557637
45Glutathione metabolism_Homo sapiens_hsa004801.03754830
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03005224
47Collecting duct acid secretion_Homo sapiens_hsa049661.00264595
48DNA replication_Homo sapiens_hsa030300.96561669
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93679432
50Basal cell carcinoma_Homo sapiens_hsa052170.90697732
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89133613
52RNA degradation_Homo sapiens_hsa030180.87965232
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87645238
54Parkinsons disease_Homo sapiens_hsa050120.84438861
55Carbon metabolism_Homo sapiens_hsa012000.83384071
56Nucleotide excision repair_Homo sapiens_hsa034200.80819850
57Mineral absorption_Homo sapiens_hsa049780.80553444
58Amphetamine addiction_Homo sapiens_hsa050310.79446373
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78131701
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77550733
61p53 signaling pathway_Homo sapiens_hsa041150.77392138
62Arachidonic acid metabolism_Homo sapiens_hsa005900.76765394
63Cardiac muscle contraction_Homo sapiens_hsa042600.75058130
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74358263
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73454109
66Butanoate metabolism_Homo sapiens_hsa006500.68955572
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67776770
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67450152
69Fat digestion and absorption_Homo sapiens_hsa049750.66328717
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.65729141
71Metabolic pathways_Homo sapiens_hsa011000.65622176
72Antigen processing and presentation_Homo sapiens_hsa046120.64281957
73Vibrio cholerae infection_Homo sapiens_hsa051100.64112787
74Biosynthesis of amino acids_Homo sapiens_hsa012300.63591210
75Base excision repair_Homo sapiens_hsa034100.63239488
76Phototransduction_Homo sapiens_hsa047440.62984429
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.62825263
78Systemic lupus erythematosus_Homo sapiens_hsa053220.62731070
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62611772
80Nicotine addiction_Homo sapiens_hsa050330.61542172
81Sphingolipid metabolism_Homo sapiens_hsa006000.60530369
82Mismatch repair_Homo sapiens_hsa034300.59923503
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58113154
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55867621
85Arginine and proline metabolism_Homo sapiens_hsa003300.55818911
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55575840
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55303040
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54991105
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54645593
90Alzheimers disease_Homo sapiens_hsa050100.53874625
91Tryptophan metabolism_Homo sapiens_hsa003800.51865691
92PPAR signaling pathway_Homo sapiens_hsa033200.51255213
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50240313
94Folate biosynthesis_Homo sapiens_hsa007900.49735765
95Notch signaling pathway_Homo sapiens_hsa043300.48374243
96Vitamin digestion and absorption_Homo sapiens_hsa049770.47164904
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44834796
98Sulfur metabolism_Homo sapiens_hsa009200.44380068
99Fatty acid metabolism_Homo sapiens_hsa012120.43157748
100Fatty acid elongation_Homo sapiens_hsa000620.42103983
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41540208
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.40780942
103Hedgehog signaling pathway_Homo sapiens_hsa043400.39135389
104Olfactory transduction_Homo sapiens_hsa047400.36702777
105Endocytosis_Homo sapiens_hsa041440.36323167
106Insulin secretion_Homo sapiens_hsa049110.34893589
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33859689
108Hippo signaling pathway_Homo sapiens_hsa043900.30558679
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29797259
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28475273
111Galactose metabolism_Homo sapiens_hsa000520.27716017
112Viral carcinogenesis_Homo sapiens_hsa052030.26958591
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25235081
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.24116297
115Renin-angiotensin system_Homo sapiens_hsa046140.22723878
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21676075
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.21098442
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21000458
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19670725
120One carbon pool by folate_Homo sapiens_hsa006700.19231961
121Morphine addiction_Homo sapiens_hsa050320.18982311
122Cocaine addiction_Homo sapiens_hsa050300.18602617
123Renin secretion_Homo sapiens_hsa049240.18213297
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17568628
125Estrogen signaling pathway_Homo sapiens_hsa049150.17552693
126Tight junction_Homo sapiens_hsa045300.16697981
127beta-Alanine metabolism_Homo sapiens_hsa004100.15411936
128Alcoholism_Homo sapiens_hsa050340.14565319
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14280109
130HTLV-I infection_Homo sapiens_hsa051660.14248339
131Dopaminergic synapse_Homo sapiens_hsa047280.14114323
132Synaptic vesicle cycle_Homo sapiens_hsa047210.12912008
133Non-homologous end-joining_Homo sapiens_hsa034500.12805811
134Chemical carcinogenesis_Homo sapiens_hsa052040.12226765
135Steroid biosynthesis_Homo sapiens_hsa001000.11704095
136Fatty acid degradation_Homo sapiens_hsa000710.10912250

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