SYCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.56959244
2male meiosis (GO:0007140)9.51170989
3* synaptonemal complex assembly (GO:0007130)8.98592401
4* synaptonemal complex organization (GO:0070193)8.82382999
5regulation of meiosis I (GO:0060631)8.17111393
6male meiosis I (GO:0007141)7.59898717
7cilium or flagellum-dependent cell motility (GO:0001539)7.35471121
8meiotic nuclear division (GO:0007126)6.95918590
9* chromosome organization involved in meiosis (GO:0070192)6.91639476
10meiosis I (GO:0007127)6.36366325
11meiotic chromosome segregation (GO:0045132)5.77798839
12histone H3-K9 demethylation (GO:0033169)5.19668299
13fusion of sperm to egg plasma membrane (GO:0007342)5.16734834
14* meiotic cell cycle process (GO:1903046)5.14217876
15nuclear pore complex assembly (GO:0051292)4.96522524
16gene silencing by RNA (GO:0031047)4.87206219
17axonemal dynein complex assembly (GO:0070286)4.77563395
18spermatid development (GO:0007286)4.75439572
19DNA methylation (GO:0006306)4.70201938
20DNA alkylation (GO:0006305)4.70201938
21nuclear pore organization (GO:0006999)4.69339510
22regulation of meiotic cell cycle (GO:0051445)4.66075759
23synapsis (GO:0007129)4.56318975
24oogenesis (GO:0048477)4.47843801
25histone H3-K36 demethylation (GO:0070544)4.46676918
26meiotic cell cycle (GO:0051321)4.44266103
27resolution of meiotic recombination intermediates (GO:0000712)4.42792898
28* reciprocal DNA recombination (GO:0035825)4.40377779
29* reciprocal meiotic recombination (GO:0007131)4.40377779
30protein localization to chromosome (GO:0034502)4.34696649
31negative regulation of meiosis (GO:0045835)4.32283823
32negative regulation of inclusion body assembly (GO:0090084)4.29667232
33regulation of DNA endoreduplication (GO:0032875)4.28659887
34sister chromatid cohesion (GO:0007062)4.27894872
35motile cilium assembly (GO:0044458)4.27325943
36kinetochore organization (GO:0051383)4.24224052
37sperm motility (GO:0030317)4.23602840
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.10302037
39reproductive system development (GO:0061458)4.10243504
40protein K6-linked ubiquitination (GO:0085020)4.07519755
41sperm-egg recognition (GO:0035036)4.05260259
42kinetochore assembly (GO:0051382)4.01855948
43positive regulation of meiosis (GO:0045836)3.96082145
44microtubule depolymerization (GO:0007019)3.94802988
45plasma membrane fusion (GO:0045026)3.94517527
46pore complex assembly (GO:0046931)3.93407466
47germ cell development (GO:0007281)3.91781595
48replicative senescence (GO:0090399)3.91127438
49binding of sperm to zona pellucida (GO:0007339)3.90607522
50DNA methylation or demethylation (GO:0044728)3.88808469
51multicellular organism reproduction (GO:0032504)3.81259081
52histone exchange (GO:0043486)3.80064249
53positive regulation of response to oxidative stress (GO:1902884)3.77892224
54positive regulation of cellular response to oxidative stress (GO:1900409)3.77892224
55regulation of centriole replication (GO:0046599)3.77465282
56epithelial cilium movement (GO:0003351)3.75537108
57intra-S DNA damage checkpoint (GO:0031573)3.72171277
58positive regulation of meiotic cell cycle (GO:0051446)3.70534719
59acrosome assembly (GO:0001675)3.66333852
60female gamete generation (GO:0007292)3.65441003
61cell-cell recognition (GO:0009988)3.59140035
62* male gamete generation (GO:0048232)3.52807606
63* spermatogenesis (GO:0007283)3.52646274
64monoubiquitinated protein deubiquitination (GO:0035520)3.43121846
65chromatin remodeling at centromere (GO:0031055)3.42348495
66negative regulation of gene silencing (GO:0060969)3.42051716
67cilium movement (GO:0003341)3.34697168
68gene silencing (GO:0016458)3.33890854
69histone H2A acetylation (GO:0043968)3.31643427
70* gamete generation (GO:0007276)3.30604965
71* cellular process involved in reproduction in multicellular organism (GO:0022412)3.30545711
72histone H3-K9 methylation (GO:0051567)3.29675225
73negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.26247594
74DNA modification (GO:0006304)3.25693370
75regulation of histone H3-K9 methylation (GO:0051570)3.24088236
76regulation of transcription from RNA polymerase I promoter (GO:0006356)3.20527184
77oocyte maturation (GO:0001556)3.19899811
78genitalia morphogenesis (GO:0035112)3.19212262
79regulation of protein polyubiquitination (GO:1902914)3.19129740
80proteasome assembly (GO:0043248)3.18270656
81fertilization (GO:0009566)3.15259312
82regulation of helicase activity (GO:0051095)3.09438753
83translesion synthesis (GO:0019985)3.07789168
84poly(A)+ mRNA export from nucleus (GO:0016973)3.07683515
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.07134466
86attachment of spindle microtubules to kinetochore (GO:0008608)3.06887104
87mitotic metaphase plate congression (GO:0007080)3.04372978
88interkinetic nuclear migration (GO:0022027)3.04156413
89CENP-A containing nucleosome assembly (GO:0034080)3.03500189
90mitotic sister chromatid cohesion (GO:0007064)3.02269628
91regulation of meiosis (GO:0040020)3.01782664
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.01619384
93* DNA biosynthetic process (GO:0071897)2.99139066
94histone H4-K12 acetylation (GO:0043983)2.98018761
95regulation of cilium movement (GO:0003352)2.97939049
96regulation of microtubule-based movement (GO:0060632)2.97909150
97acrosome reaction (GO:0007340)2.95720869
98* DNA synthesis involved in DNA repair (GO:0000731)2.94772297
99metaphase plate congression (GO:0051310)2.93114062
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92021443
101negative regulation of sister chromatid segregation (GO:0033046)2.92021443
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.92021443
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92021443
104negative regulation of chromosome segregation (GO:0051985)2.91371176
105cellular response to gamma radiation (GO:0071480)2.91093949
106* chromosome organization (GO:0051276)2.89984864
107centriole assembly (GO:0098534)2.88979323
108spindle assembly checkpoint (GO:0071173)2.88400422
109mitotic spindle assembly checkpoint (GO:0007094)2.88154130
110DNA replication-independent nucleosome organization (GO:0034724)2.87474551
111DNA replication-independent nucleosome assembly (GO:0006336)2.87474551
112organelle fission (GO:0048285)2.85374891
113regulation of chromosome segregation (GO:0051983)2.85249060
114positive regulation of translational initiation (GO:0045948)2.84768023
115nuclear division (GO:0000280)2.84621209
116negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.83891790
117negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.83144606
118sex differentiation (GO:0007548)2.80020426
119photoreceptor cell maintenance (GO:0045494)2.76407877
120histone lysine demethylation (GO:0070076)2.75537076
121intraciliary transport (GO:0042073)2.69817679
122histone demethylation (GO:0016577)2.66311148
123positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.60275870
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58529050
125mitotic spindle checkpoint (GO:0071174)2.57991196
126DNA catabolic process, exonucleolytic (GO:0000738)2.57591074
127DNA replication-dependent nucleosome organization (GO:0034723)2.52384281
128DNA replication-dependent nucleosome assembly (GO:0006335)2.52384281
129protein demethylation (GO:0006482)2.50483062
130protein dealkylation (GO:0008214)2.50483062
131axoneme assembly (GO:0035082)2.46727787
132protein refolding (GO:0042026)2.41681820
133striatum development (GO:0021756)2.39584051
134negative regulation of DNA repair (GO:0045738)2.39357625
135histone H4-K16 acetylation (GO:0043984)2.38475877
136microtubule anchoring (GO:0034453)2.37129680
137regulation of inclusion body assembly (GO:0090083)2.36388939
138spindle checkpoint (GO:0031577)2.31633135
139piRNA metabolic process (GO:0034587)12.5876493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.72093053
2E2F7_22180533_ChIP-Seq_HELA_Human5.94506506
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.21036629
4ZNF274_21170338_ChIP-Seq_K562_Hela2.95659447
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89163766
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.82541877
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.78048346
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73179915
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.63808432
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63216502
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.59979052
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39271879
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31456509
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29404165
15* ER_23166858_ChIP-Seq_MCF-7_Human2.28386421
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27910586
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16340799
18BCAT_22108803_ChIP-Seq_LS180_Human2.12768625
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.12019479
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09316857
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06826109
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05486130
23TAF15_26573619_Chip-Seq_HEK293_Human1.98683290
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.87592671
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78563404
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77816179
27KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77388421
28* RNF2_27304074_Chip-Seq_NSC_Mouse1.72088260
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71900924
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71437039
31P300_19829295_ChIP-Seq_ESCs_Human1.70538690
32AR_25329375_ChIP-Seq_VCAP_Human1.70125143
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68421109
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64093476
35TP53_22573176_ChIP-Seq_HFKS_Human1.62337906
36KLF5_20875108_ChIP-Seq_MESCs_Mouse1.61642899
37FUS_26573619_Chip-Seq_HEK293_Human1.60478155
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.60372768
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59225665
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59053232
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58815634
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58356302
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56932729
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56346384
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56023454
46* RUNX2_22187159_ChIP-Seq_PCA_Human1.54006145
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.53968059
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51950307
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51881347
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48914766
51IGF1R_20145208_ChIP-Seq_DFB_Human1.48177958
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.47620085
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.44872498
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.43585865
55* STAT3_18555785_Chip-Seq_ESCs_Mouse1.43429630
56MYC_18940864_ChIP-ChIP_HL60_Human1.43033783
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.41443755
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40969203
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39306596
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38813741
61CBP_20019798_ChIP-Seq_JUKART_Human1.38676307
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38676307
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.36271205
64* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36029254
65EWS_26573619_Chip-Seq_HEK293_Human1.35567806
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35040532
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.35040532
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34884134
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34257058
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34257058
71* SMAD4_21741376_ChIP-Seq_EPCs_Human1.34189285
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.32196473
73P53_22387025_ChIP-Seq_ESCs_Mouse1.29020755
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28475636
75SMAD4_21799915_ChIP-Seq_A2780_Human1.28252411
76* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28102672
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26982252
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24280021
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24000276
80RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23792905
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23683485
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.23586431
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22568456
84TCF4_22108803_ChIP-Seq_LS180_Human1.21849210
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21435442
86ZFX_18555785_Chip-Seq_ESCs_Mouse1.21153529
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20624508
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20581514
89P300_18555785_Chip-Seq_ESCs_Mouse1.20579247
90HOXB7_26014856_ChIP-Seq_BT474_Human1.19905027
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19760320
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19760320
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19760320
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19043125
95* ERA_21632823_ChIP-Seq_H3396_Human1.18545417
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.18360480
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.17800789
98NANOG_19829295_ChIP-Seq_ESCs_Human1.17635482
99SOX2_19829295_ChIP-Seq_ESCs_Human1.17635482
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.17408117
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16908014
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16838021
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.15693604
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14522715
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.13877280
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13052756
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12794721
108* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12418540
109* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12260113
110AR_21909140_ChIP-Seq_LNCAP_Human1.11993958
111EZH2_22144423_ChIP-Seq_EOC_Human1.11787979
112PU1_27457419_Chip-Seq_LIVER_Mouse1.11042998
113AR_20517297_ChIP-Seq_VCAP_Human1.11002754
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10951843
115HTT_18923047_ChIP-ChIP_STHdh_Human1.10471638
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09715835
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09683232
118* TCF4_23295773_ChIP-Seq_U87_Human1.09369226
119GATA3_26560356_Chip-Seq_TH1_Human1.08951938
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.07258274
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06538923
122FOXH1_21741376_ChIP-Seq_EPCs_Human1.06477697
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.06071367
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05913067
125* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05787102
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.05713825
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05324332
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04403718
129STAT1_17558387_ChIP-Seq_HELA_Human1.04231881
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04064346
131MYC_19829295_ChIP-Seq_ESCs_Human1.03987810
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02218597
133GBX2_23144817_ChIP-Seq_PC3_Human1.01941549
134* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01768088
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01591982
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01242171
137VDR_22108803_ChIP-Seq_LS180_Human0.99758496
138STAT3_23295773_ChIP-Seq_U87_Human0.99323871
139* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98917501
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98417291
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97959726
142GABP_17652178_ChIP-ChIP_JURKAT_Human0.97505367
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97359585
144WDR5_24793694_ChIP-Seq_LNCAP_Human0.96949360
145CDX2_22108803_ChIP-Seq_LS180_Human0.95312761
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94686871
147NOTCH1_21737748_ChIP-Seq_TLL_Human0.93383094
148DCP1A_22483619_ChIP-Seq_HELA_Human0.92909849
149LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92220444
150VDR_23849224_ChIP-Seq_CD4+_Human0.91515684
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91381239
152YY1_21170310_ChIP-Seq_MESCs_Mouse0.91278121
153* ETV1_20927104_ChIP-Seq_GIST48_Human0.90987015
154MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90954538
155EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90919763
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89797790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.14173167
2MP0005410_abnormal_fertilization4.49781982
3MP0008057_abnormal_DNA_replication4.20751002
4MP0008995_early_reproductive_senescence4.13937096
5MP0008058_abnormal_DNA_repair4.04207251
6* MP0002210_abnormal_sex_determination3.95665352
7* MP0001929_abnormal_gametogenesis3.75346671
8MP0010094_abnormal_chromosome_stability3.57296098
9* MP0003698_abnormal_male_reproductive3.44634778
10MP0003786_premature_aging3.33360671
11* MP0001145_abnormal_male_reproductive3.10332403
12MP0003111_abnormal_nucleus_morphology3.09560746
13MP0003693_abnormal_embryo_hatching2.84624557
14* MP0000653_abnormal_sex_gland2.77226376
15MP0008004_abnormal_stomach_pH2.59497439
16MP0008007_abnormal_cellular_replicative2.47617917
17MP0000569_abnormal_digit_pigmentation2.36397466
18MP0003077_abnormal_cell_cycle2.27116305
19MP0006292_abnormal_olfactory_placode1.98588143
20MP0005377_hearing/vestibular/ear_phenot1.91743830
21MP0003878_abnormal_ear_physiology1.91743830
22MP0002160_abnormal_reproductive_system1.89045886
23* MP0002161_abnormal_fertility/fecundity1.88323468
24MP0003787_abnormal_imprinting1.88087621
25MP0001188_hyperpigmentation1.74563806
26MP0002653_abnormal_ependyma_morphology1.66961628
27* MP0001119_abnormal_female_reproductive1.54328342
28MP0003123_paternal_imprinting1.54168246
29MP0004957_abnormal_blastocyst_morpholog1.48735756
30MP0010678_abnormal_skin_adnexa1.48105528
31MP0010307_abnormal_tumor_latency1.47612539
32MP0003121_genomic_imprinting1.46955030
33MP0003941_abnormal_skin_development1.45277288
34MP0000678_abnormal_parathyroid_gland1.43512673
35MP0005647_abnormal_sex_gland1.38607207
36MP0004808_abnormal_hematopoietic_stem1.36884190
37MP0008789_abnormal_olfactory_epithelium1.31036498
38MP0005389_reproductive_system_phenotype1.26272197
39MP0002095_abnormal_skin_pigmentation1.23583002
40MP0000566_synostosis1.17339664
41MP0005423_abnormal_somatic_nervous1.16792727
42MP0008932_abnormal_embryonic_tissue1.16647265
43MP0003890_abnormal_embryonic-extraembry1.14901935
44MP0005670_abnormal_white_adipose1.12621752
45MP0000427_abnormal_hair_cycle1.09622991
46MP0001293_anophthalmia1.08818772
47MP0009697_abnormal_copulation1.07072475
48MP0003718_maternal_effect1.05714081
49MP0002102_abnormal_ear_morphology1.03542631
50MP0003646_muscle_fatigue1.01631584
51MP0001501_abnormal_sleep_pattern0.96005322
52* MP0003699_abnormal_female_reproductive0.94246299
53MP0000313_abnormal_cell_death0.90413233
54MP0000350_abnormal_cell_proliferation0.89325752
55MP0003136_yellow_coat_color0.86496641
56MP0000647_abnormal_sebaceous_gland0.86195774
57MP0006035_abnormal_mitochondrial_morpho0.86025141
58MP0000579_abnormal_nail_morphology0.85961710
59MP0005551_abnormal_eye_electrophysiolog0.85105844
60MP0001485_abnormal_pinna_reflex0.84889800
61MP0005253_abnormal_eye_physiology0.84729180
62MP0005310_abnormal_salivary_gland0.83921017
63MP0000778_abnormal_nervous_system0.83484084
64MP0003880_abnormal_central_pattern0.82896881
65MP0003936_abnormal_reproductive_system0.81756124
66MP0005171_absent_coat_pigmentation0.79764305
67MP0000358_abnormal_cell_content/0.79563134
68MP0001661_extended_life_span0.78990662
69MP0001730_embryonic_growth_arrest0.78388509
70MP0008260_abnormal_autophagy0.78249482
71MP0005174_abnormal_tail_pigmentation0.76619245
72MP0001486_abnormal_startle_reflex0.75730225
73MP0005380_embryogenesis_phenotype0.75501600
74MP0001672_abnormal_embryogenesis/_devel0.75501600
75MP0002638_abnormal_pupillary_reflex0.75177939
76MP0000015_abnormal_ear_pigmentation0.71773869
77MP0000372_irregular_coat_pigmentation0.71179720
78MP0005275_abnormal_skin_tensile0.70496155
79MP0009278_abnormal_bone_marrow0.70198845
80MP0000631_abnormal_neuroendocrine_gland0.70135457
81MP0004197_abnormal_fetal_growth/weight/0.69818915
82MP0002085_abnormal_embryonic_tissue0.69381943
83MP0001545_abnormal_hematopoietic_system0.69220123
84MP0005397_hematopoietic_system_phenotyp0.69220123
85MP0002277_abnormal_respiratory_mucosa0.69198810
86MP0005394_taste/olfaction_phenotype0.68020079
87MP0005499_abnormal_olfactory_system0.68020079
88MP0004043_abnormal_pH_regulation0.67012266
89MP0001502_abnormal_circadian_rhythm0.66749677
90MP0002396_abnormal_hematopoietic_system0.65675983
91MP0002282_abnormal_trachea_morphology0.64783592
92MP0002075_abnormal_coat/hair_pigmentati0.63949007
93MP0001919_abnormal_reproductive_system0.63929145
94MP0009703_decreased_birth_body0.63719761
95MP0003119_abnormal_digestive_system0.63559785
96MP0004215_abnormal_myocardial_fiber0.63537750
97MP0005391_vision/eye_phenotype0.63055960
98MP0004742_abnormal_vestibular_system0.62166174
99MP0000371_diluted_coat_color0.61686433
100MP0002067_abnormal_sensory_capabilities0.61460713
101MP0000013_abnormal_adipose_tissue0.61020256
102MP0004133_heterotaxia0.60589425
103MP0002084_abnormal_developmental_patter0.60390369
104MP0003943_abnormal_hepatobiliary_system0.59218798
105MP0002736_abnormal_nociception_after0.58941777
106MP0003950_abnormal_plasma_membrane0.58621435
107MP0003984_embryonic_growth_retardation0.58550142
108MP0005395_other_phenotype0.58499873
109MP0002876_abnormal_thyroid_physiology0.57872415
110MP0006276_abnormal_autonomic_nervous0.57288934
111MP0001968_abnormal_touch/_nociception0.55705165
112MP0001186_pigmentation_phenotype0.55099774
113MP0003045_fibrosis0.54184992
114MP0004134_abnormal_chest_morphology0.54096990
115MP0000432_abnormal_head_morphology0.53691038
116MP0004924_abnormal_behavior0.53471909
117MP0005386_behavior/neurological_phenoty0.53471909
118MP0002088_abnormal_embryonic_growth/wei0.53391204
119MP0000383_abnormal_hair_follicle0.53048714
120MP0009250_abnormal_appendicular_skeleto0.51513846
121MP0002019_abnormal_tumor_incidence0.51358101
122MP0005646_abnormal_pituitary_gland0.51262066
123MP0001529_abnormal_vocalization0.50606390
124MP0001697_abnormal_embryo_size0.50488317
125MP0002249_abnormal_larynx_morphology0.49195457
126MP0002938_white_spotting0.48655319
127MP0003183_abnormal_peptide_metabolism0.48620979
128MP0006072_abnormal_retinal_apoptosis0.47956937
129MP0001764_abnormal_homeostasis0.47168633
130MP0001986_abnormal_taste_sensitivity0.46742699
131MP0003567_abnormal_fetal_cardiomyocyte0.46327844
132MP0003315_abnormal_perineum_morphology0.46101460
133MP0004885_abnormal_endolymph0.46040351
134MP0002163_abnormal_gland_morphology0.45385002
135MP0003879_abnormal_hair_cell0.45382412
136MP0003195_calcinosis0.44978068
137MP0010030_abnormal_orbit_morphology0.44752264
138MP0000490_abnormal_crypts_of0.44590594
139MP0001664_abnormal_digestion0.44355007
140MP0002086_abnormal_extraembryonic_tissu0.44068539
141MP0006036_abnormal_mitochondrial_physio0.43854867
142MP0009745_abnormal_behavioral_response0.42894953
143MP0001915_intracranial_hemorrhage0.42577168
144MP0001984_abnormal_olfaction0.42495082
145MP0009672_abnormal_birth_weight0.42071694
146MP0003937_abnormal_limbs/digits/tail_de0.42050817
147MP0003283_abnormal_digestive_organ0.41588413
148MP0001324_abnormal_eye_pigmentation0.41507982
149MP0005621_abnormal_cell_physiology0.40805918
150MP0005384_cellular_phenotype0.40737226

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.05035669
2Spontaneous abortion (HP:0005268)6.04916184
3Absent/shortened dynein arms (HP:0200106)5.94475572
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.94475572
5Volvulus (HP:0002580)5.91632629
6Azoospermia (HP:0000027)5.44252996
7Chromosomal breakage induced by crosslinking agents (HP:0003221)5.24614295
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.12342809
9Degeneration of the lateral corticospinal tracts (HP:0002314)5.12342809
10Abnormal spermatogenesis (HP:0008669)5.09174227
11Chromsome breakage (HP:0040012)5.01213075
12Shoulder girdle muscle weakness (HP:0003547)4.69756873
13Abnormal respiratory motile cilium physiology (HP:0012261)4.33017114
14Rimmed vacuoles (HP:0003805)4.28584292
15Gonadotropin excess (HP:0000837)4.20178798
16Abnormal respiratory epithelium morphology (HP:0012253)4.17175801
17Abnormal respiratory motile cilium morphology (HP:0005938)4.17175801
18Oligodactyly (HP:0012165)4.00747615
19Abnormality of the corticospinal tract (HP:0002492)3.83847149
20Abnormal ciliary motility (HP:0012262)3.78179657
21Nephronophthisis (HP:0000090)3.62626987
22Tubulointerstitial nephritis (HP:0001970)3.34755448
23Rhinitis (HP:0012384)3.31702102
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.30794843
25Meckel diverticulum (HP:0002245)3.27928509
26Abnormality of the lower motor neuron (HP:0002366)3.26705049
27Impaired vibration sensation in the lower limbs (HP:0002166)3.19051119
28Supernumerary spleens (HP:0009799)3.14137445
29Ectopic kidney (HP:0000086)3.12476296
30Impulsivity (HP:0100710)3.10570611
31Abnormality of the ileum (HP:0001549)3.09568229
32Abnormality of chromosome stability (HP:0003220)3.09507472
33Facial cleft (HP:0002006)3.02909009
3411 pairs of ribs (HP:0000878)2.97702034
35Infertility (HP:0000789)2.97681361
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.93967424
37Abnormality of the renal medulla (HP:0100957)2.93287583
38Abnormality of the preputium (HP:0100587)2.92990212
39Median cleft lip (HP:0000161)2.91709142
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87906983
41Abnormality of alanine metabolism (HP:0010916)2.87906983
42Hyperalaninemia (HP:0003348)2.87906983
43Degeneration of anterior horn cells (HP:0002398)2.87588133
44Abnormality of the anterior horn cell (HP:0006802)2.87588133
45Facial hemangioma (HP:0000329)2.85860555
46Increased nuchal translucency (HP:0010880)2.84989639
47Horizontal nystagmus (HP:0000666)2.75218524
48Follicular hyperkeratosis (HP:0007502)2.75155565
49Capillary hemangiomas (HP:0005306)2.73892537
50Fibular hypoplasia (HP:0003038)2.73037253
51Postaxial foot polydactyly (HP:0001830)2.70134201
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.69248837
53Fair hair (HP:0002286)2.68497261
54Upper motor neuron abnormality (HP:0002127)2.58318958
55Chronic bronchitis (HP:0004469)2.56001945
56Clubbing of toes (HP:0100760)2.49023836
57Pancreatic fibrosis (HP:0100732)2.47927195
58Small intestinal stenosis (HP:0012848)2.47257867
59Duodenal stenosis (HP:0100867)2.47257867
60Abnormality of the carotid arteries (HP:0005344)2.45945479
61Pili torti (HP:0003777)2.45248737
62Selective tooth agenesis (HP:0001592)2.43861395
63Male pseudohermaphroditism (HP:0000037)2.38181570
64Congenital, generalized hypertrichosis (HP:0004540)2.38147311
65Abnormality of DNA repair (HP:0003254)2.37124456
66Abnormal lung lobation (HP:0002101)2.36020094
67Non-midline cleft lip (HP:0100335)2.33512332
68Prostate neoplasm (HP:0100787)2.31801959
69Gait imbalance (HP:0002141)2.31331471
70Sloping forehead (HP:0000340)2.31076300
71Widely spaced teeth (HP:0000687)2.30772266
72Urinary urgency (HP:0000012)2.30088802
73Chronic hepatic failure (HP:0100626)2.28648370
74Medial flaring of the eyebrow (HP:0010747)2.27136921
75Hypoplastic iliac wings (HP:0002866)2.26358584
76Type II lissencephaly (HP:0007260)2.26192062
77Scotoma (HP:0000575)2.25871935
78Nephroblastoma (Wilms tumor) (HP:0002667)2.24886024
79Birth length less than 3rd percentile (HP:0003561)2.23442820
80Congenital hepatic fibrosis (HP:0002612)2.22297205
81True hermaphroditism (HP:0010459)2.22029793
82Duplicated collecting system (HP:0000081)2.21990882
83Abnormal glycosylation (HP:0012345)2.21963778
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21963778
85Abnormal protein N-linked glycosylation (HP:0012347)2.21963778
86Abnormal protein glycosylation (HP:0012346)2.21963778
87Nephrogenic diabetes insipidus (HP:0009806)2.21336567
88Urinary bladder sphincter dysfunction (HP:0002839)2.21098234
89Broad distal phalanx of finger (HP:0009836)2.21008092
90Abnormality of midbrain morphology (HP:0002418)2.20981573
91Molar tooth sign on MRI (HP:0002419)2.20981573
92Truncal obesity (HP:0001956)2.20068380
93Large hands (HP:0001176)2.17052242
94Multicystic kidney dysplasia (HP:0000003)2.16376103
95Septo-optic dysplasia (HP:0100842)2.13933530
96Bronchiectasis (HP:0002110)2.13222865
97Abnormality of chromosome segregation (HP:0002916)2.12441133
98Pancreatic cysts (HP:0001737)2.12182518
99Male infertility (HP:0003251)2.09823949
100Abnormality of the renal cortex (HP:0011035)2.08089237
101Spastic gait (HP:0002064)2.07678186
102Abnormality of the labia minora (HP:0012880)2.06864436
103Abnormality of the renal collecting system (HP:0004742)2.06404183
104Embryonal renal neoplasm (HP:0011794)2.05915234
105Impaired vibratory sensation (HP:0002495)2.01592169
106Preaxial hand polydactyly (HP:0001177)2.00377567
107Dyschromatopsia (HP:0007641)1.98843535
108Aplasia/Hypoplasia of the fibula (HP:0006492)1.98298652
109Hypoplastic labia majora (HP:0000059)1.97399977
110Abnormality of the duodenum (HP:0002246)1.94387420
111Occipital encephalocele (HP:0002085)1.92582068
112Genital tract atresia (HP:0001827)1.92472016
113Papillary thyroid carcinoma (HP:0002895)1.90423076
114Renal dysplasia (HP:0000110)1.88911613
115Breast carcinoma (HP:0003002)1.88693052
116Generalized hypopigmentation of hair (HP:0011358)1.88032725
117Prominent nose (HP:0000448)1.87631576
118Absent thumb (HP:0009777)1.87530910
119Myelodysplasia (HP:0002863)1.87098699
120Cystic liver disease (HP:0006706)1.86389082
121Poor coordination (HP:0002370)1.84198512
122Tubular atrophy (HP:0000092)1.83783489
123Hyperpituitarism (HP:0010514)1.82794490
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.82512948
125Tubulointerstitial abnormality (HP:0001969)1.82365154
126Abnormality of the labia (HP:0000058)1.81158982
127Protruding tongue (HP:0010808)1.80735502
128Anal stenosis (HP:0002025)1.79261165
129Limb-girdle muscle weakness (HP:0003325)1.78544996
130Impaired proprioception (HP:0010831)1.78169018
131Retinal dysplasia (HP:0007973)1.76448483
132Amyotrophic lateral sclerosis (HP:0007354)1.76127254
133Vaginal atresia (HP:0000148)1.75426611
134Small hand (HP:0200055)1.74685960
135Stage 5 chronic kidney disease (HP:0003774)1.74152489
136Abnormality of the labia majora (HP:0012881)1.73989063
137Spastic paraplegia (HP:0001258)1.73918498
138Congenital stationary night blindness (HP:0007642)1.72774224
139Short thorax (HP:0010306)1.72219963
140Morphological abnormality of the pyramidal tract (HP:0002062)1.72079015
141Abnormality of cochlea (HP:0000375)1.71369969
142Absent speech (HP:0001344)1.71033506
143Bone marrow hypocellularity (HP:0005528)1.70327562
144Abnormality of male internal genitalia (HP:0000022)1.70311417
145Type I transferrin isoform profile (HP:0003642)1.69311282
146Breast hypoplasia (HP:0003187)1.68482883
147Osteomalacia (HP:0002749)1.68236317
148Lower limb muscle weakness (HP:0007340)1.67933466
149Proximal placement of thumb (HP:0009623)1.67050232
150Nasal polyposis (HP:0100582)1.66590799
151Short thumb (HP:0009778)1.66340395
152Glioma (HP:0009733)1.65963212
153Oligodactyly (hands) (HP:0001180)1.64961469
154Abnormality of the vocal cords (HP:0008777)1.64329510
155Astigmatism (HP:0000483)1.62893828
156Absent radius (HP:0003974)1.62563744
157Abnormality of the fingertips (HP:0001211)1.62014039
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.60264667
159Postaxial hand polydactyly (HP:0001162)1.59908467
160Medulloblastoma (HP:0002885)1.59357161
161Congenital primary aphakia (HP:0007707)1.58814474
162Optic nerve hypoplasia (HP:0000609)1.58569002
163Aplasia/Hypoplasia of the earlobes (HP:0009906)1.58519256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.79702585
2PDK35.17114572
3PDK45.17114572
4CDK123.66550427
5PDK23.48782118
6CDC73.48540990
7OXSR12.96828892
8ACVR1B2.81744391
9ZAK2.66622279
10FRK2.56343754
11PLK42.54440337
12NEK22.41746870
13WEE12.31706679
14MET2.29963359
15SRPK12.20600885
16NEK92.14912848
17ATR2.10489066
18BRD41.96364414
19TTK1.92279147
20STK38L1.89485749
21PINK11.75889119
22MKNK21.75770449
23PLK11.69575414
24EIF2AK21.68777984
25CDK31.52555558
26STK31.50142479
27EIF2AK31.49707738
28WNK31.45315216
29CHEK21.44341139
30PNCK1.41240655
31AKT31.32598086
32MAP2K71.30945660
33MAPK131.28480856
34CDK71.27586553
35CSF1R1.26631956
36CHEK11.24826064
37FGR1.19714322
38TNIK1.16073795
39ATM1.15778725
40EIF2AK11.13677154
41PBK1.12589382
42MKNK11.09585319
43STK161.08319836
44DYRK31.07510512
45PLK31.07478113
46ICK1.07107060
47BMX1.06327451
48BUB11.04872864
49BRSK21.03661521
50IRAK31.02574533
51MAP3K41.02416498
52ADRBK21.01284715
53MAP4K20.97375164
54STK40.93681830
55RPS6KA40.90684700
56CDK80.90275189
57STK110.89928945
58BRAF0.87711155
59PRKCI0.85306006
60TXK0.83026802
61SIK30.82473608
62CCNB10.82394618
63BMPR1B0.81222409
64PDGFRB0.81137025
65YES10.80389064
66AURKB0.78472015
67SGK20.77597483
68PDK10.75678199
69PRKD30.75240286
70CAMK1D0.74527139
71NEK10.73344181
72NEK60.69344861
73CDK90.68420293
74RET0.64393258
75STK240.64267382
76LATS10.63810593
77CDK10.63638223
78IRAK10.63299091
79PASK0.62935425
80CDK20.62881684
81EGFR0.62319302
82STK380.61526252
83MAP3K60.60667560
84PTK2B0.60055898
85TLK10.59333439
86VRK10.58928878
87WNK10.58923588
88SGK10.58534245
89EPHA20.58269912
90MARK30.58208314
91TESK10.58185361
92TAOK20.57462887
93CDK40.55407041
94PDPK10.54917510
95CAMK1G0.54808813
96MELK0.54386545
97CASK0.54155420
98ERBB30.53300710
99GRK10.52807073
100NUAK10.52343112
101GRK70.50579037
102CHUK0.47877194
103INSRR0.46449683
104MAP3K130.46175720
105STK390.41745361
106RPS6KB10.40916538
107DYRK1A0.40413093
108GSK3B0.38649010
109BCR0.37932657
110SGK30.37898566
111PRKDC0.37683939
112NLK0.37429743
113NTRK30.37395747
114PDGFRA0.36730690
115MAPK140.36010952
116PRKAA10.35658968
117RPS6KA50.35639987
118CSNK2A10.35232076
119MAP2K20.35226307
120CAMK10.34588994
121PRKCE0.34103633
122CDK60.33422673
123BRSK10.33210098
124KSR10.33080206
125MTOR0.32772187
126IRAK40.32151432
127IGF1R0.31829977
128TEC0.31138966
129CSNK1E0.30062467
130AKT10.29768345
131PLK20.29354382
132PIM10.29218030
133AURKA0.28995594
134ADRBK10.28409118
135MAPK80.27561290
136MAP3K50.26821420
137MUSK0.26596815
138BMPR20.26596490
139PRPF4B0.26498737
140MOS0.26391301
141EPHA40.26014539
142FGFR30.25346904
143MAP3K140.25129936
144CAMK40.25104587
145LIMK10.24385176
146PRKACB0.23616286
147MAPK70.22466642
148PRKG10.22455755
149ROCK10.21609801
150MAP3K20.20689869
151MAPKAPK50.19864977
152PIK3CG0.18438590

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.27892506
2Basal transcription factors_Homo sapiens_hsa030224.04234804
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.88802591
4Homologous recombination_Homo sapiens_hsa034403.85786951
5Propanoate metabolism_Homo sapiens_hsa006403.21075096
6Mismatch repair_Homo sapiens_hsa034302.99483582
7RNA transport_Homo sapiens_hsa030132.78607582
8Cell cycle_Homo sapiens_hsa041102.76289871
9DNA replication_Homo sapiens_hsa030302.74638318
10RNA polymerase_Homo sapiens_hsa030202.51091335
11mRNA surveillance pathway_Homo sapiens_hsa030152.49039824
12Non-homologous end-joining_Homo sapiens_hsa034502.42948923
13Nucleotide excision repair_Homo sapiens_hsa034202.38782657
14Sulfur relay system_Homo sapiens_hsa041222.12103175
15Base excision repair_Homo sapiens_hsa034102.03970722
16beta-Alanine metabolism_Homo sapiens_hsa004101.99777936
17RNA degradation_Homo sapiens_hsa030181.94766607
18Spliceosome_Homo sapiens_hsa030401.94593799
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.82225067
20p53 signaling pathway_Homo sapiens_hsa041151.81190537
21Pyrimidine metabolism_Homo sapiens_hsa002401.74656673
22Vitamin B6 metabolism_Homo sapiens_hsa007501.74492768
23Herpes simplex infection_Homo sapiens_hsa051681.72221605
24Proteasome_Homo sapiens_hsa030501.65907801
25One carbon pool by folate_Homo sapiens_hsa006701.59751525
26Dorso-ventral axis formation_Homo sapiens_hsa043201.59162252
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55684747
28Butanoate metabolism_Homo sapiens_hsa006501.54322176
29Purine metabolism_Homo sapiens_hsa002301.51917091
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44438060
31Phototransduction_Homo sapiens_hsa047441.37954184
32Selenocompound metabolism_Homo sapiens_hsa004501.37677291
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37088069
34Oocyte meiosis_Homo sapiens_hsa041141.28598945
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27393374
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23387231
37ABC transporters_Homo sapiens_hsa020101.20421322
38Epstein-Barr virus infection_Homo sapiens_hsa051691.14439066
39Influenza A_Homo sapiens_hsa051641.12984735
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02273445
41Phenylalanine metabolism_Homo sapiens_hsa003601.01071863
42Taste transduction_Homo sapiens_hsa047421.00449601
43Vitamin digestion and absorption_Homo sapiens_hsa049770.97477708
44Retinol metabolism_Homo sapiens_hsa008300.93886691
45Olfactory transduction_Homo sapiens_hsa047400.93051957
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86110158
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84691931
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.81319780
49Fatty acid degradation_Homo sapiens_hsa000710.80895479
50Antigen processing and presentation_Homo sapiens_hsa046120.80296592
51N-Glycan biosynthesis_Homo sapiens_hsa005100.78891389
52Protein export_Homo sapiens_hsa030600.77509581
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76981117
54HTLV-I infection_Homo sapiens_hsa051660.74404275
55Circadian rhythm_Homo sapiens_hsa047100.74269850
56Nitrogen metabolism_Homo sapiens_hsa009100.73317423
57mTOR signaling pathway_Homo sapiens_hsa041500.72672934
58Linoleic acid metabolism_Homo sapiens_hsa005910.72249549
59Lysine degradation_Homo sapiens_hsa003100.71565181
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71000336
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70054098
62Measles_Homo sapiens_hsa051620.69255807
63Fatty acid metabolism_Homo sapiens_hsa012120.66931441
64Arachidonic acid metabolism_Homo sapiens_hsa005900.66123533
65Parkinsons disease_Homo sapiens_hsa050120.66008914
66Legionellosis_Homo sapiens_hsa051340.65095920
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.63958858
68Tryptophan metabolism_Homo sapiens_hsa003800.63875104
69Autoimmune thyroid disease_Homo sapiens_hsa053200.61753638
70TGF-beta signaling pathway_Homo sapiens_hsa043500.60507296
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59994110
72Graft-versus-host disease_Homo sapiens_hsa053320.59949280
73Asthma_Homo sapiens_hsa053100.59832892
74Regulation of autophagy_Homo sapiens_hsa041400.58485958
75Allograft rejection_Homo sapiens_hsa053300.58367854
76Pentose phosphate pathway_Homo sapiens_hsa000300.57156231
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.56620350
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.55474147
79Basal cell carcinoma_Homo sapiens_hsa052170.55301520
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.54364510
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54102685
82Inositol phosphate metabolism_Homo sapiens_hsa005620.54047007
83Viral carcinogenesis_Homo sapiens_hsa052030.53304227
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53131760
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51749066
86Small cell lung cancer_Homo sapiens_hsa052220.50728981
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49359080
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49261612
89Peroxisome_Homo sapiens_hsa041460.47698003
90Sphingolipid metabolism_Homo sapiens_hsa006000.46584984
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.45610621
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45001759
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43477573
94Ether lipid metabolism_Homo sapiens_hsa005650.43111786
95Fatty acid biosynthesis_Homo sapiens_hsa000610.42948655
96Huntingtons disease_Homo sapiens_hsa050160.42187116
97Mineral absorption_Homo sapiens_hsa049780.42169236
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.41971964
99Glucagon signaling pathway_Homo sapiens_hsa049220.41694741
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41032853
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.41028382
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.39167476
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38076201
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37964727
105Caffeine metabolism_Homo sapiens_hsa002320.37327119
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36721816
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35483342
108TNF signaling pathway_Homo sapiens_hsa046680.35381749
109Steroid biosynthesis_Homo sapiens_hsa001000.34857357
110Choline metabolism in cancer_Homo sapiens_hsa052310.34069575
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.33719731
112Systemic lupus erythematosus_Homo sapiens_hsa053220.33349574
113Notch signaling pathway_Homo sapiens_hsa043300.32972494
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32865156
115Wnt signaling pathway_Homo sapiens_hsa043100.32375105
116FoxO signaling pathway_Homo sapiens_hsa040680.32270874
117Glycerolipid metabolism_Homo sapiens_hsa005610.31318141
118Hedgehog signaling pathway_Homo sapiens_hsa043400.30570446
119Glutamatergic synapse_Homo sapiens_hsa047240.30047269
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30008116
121Type II diabetes mellitus_Homo sapiens_hsa049300.29893959
122Adherens junction_Homo sapiens_hsa045200.29381675
123Fat digestion and absorption_Homo sapiens_hsa049750.29259680
124Circadian entrainment_Homo sapiens_hsa047130.29012904
125Metabolic pathways_Homo sapiens_hsa011000.28545812
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28470626
127Tyrosine metabolism_Homo sapiens_hsa003500.27902564
128MicroRNAs in cancer_Homo sapiens_hsa052060.27112208
129Hematopoietic cell lineage_Homo sapiens_hsa046400.26999497
130Nicotine addiction_Homo sapiens_hsa050330.25390351
131Pathways in cancer_Homo sapiens_hsa052000.24625042
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22681841
133Hippo signaling pathway_Homo sapiens_hsa043900.22181256
134Calcium signaling pathway_Homo sapiens_hsa040200.21761135
135Type I diabetes mellitus_Homo sapiens_hsa049400.21070973
136Serotonergic synapse_Homo sapiens_hsa047260.17758623
137Prostate cancer_Homo sapiens_hsa052150.17391373
138Toxoplasmosis_Homo sapiens_hsa051450.17017872
139Collecting duct acid secretion_Homo sapiens_hsa049660.17008648
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16167957
141Rheumatoid arthritis_Homo sapiens_hsa053230.15027226
142Pyruvate metabolism_Homo sapiens_hsa006200.14827733
143Apoptosis_Homo sapiens_hsa042100.12858448
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10741819
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09528553
146MAPK signaling pathway_Homo sapiens_hsa040100.08798566
147Ovarian steroidogenesis_Homo sapiens_hsa049130.08578580
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08081822
149PPAR signaling pathway_Homo sapiens_hsa033200.07279811

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