SYCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)9.46361955
2axonemal dynein complex assembly (GO:0070286)8.63641344
3acrosome assembly (GO:0001675)8.53869298
4regulation of meiosis I (GO:0060631)8.53832675
5sperm motility (GO:0030317)8.23564660
6* chromosome organization involved in meiosis (GO:0070192)7.88503412
7meiosis I (GO:0007127)7.76034282
8spermatid development (GO:0007286)7.71463374
9sperm-egg recognition (GO:0035036)7.71315841
10* meiotic nuclear division (GO:0007126)7.70460886
11multicellular organism reproduction (GO:0032504)7.67650609
12plasma membrane fusion (GO:0045026)7.67204997
13binding of sperm to zona pellucida (GO:0007339)7.30594516
14epithelial cilium movement (GO:0003351)7.27368831
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.25874313
16cell-cell recognition (GO:0009988)6.89067999
17cilium movement (GO:0003341)6.64569835
18motile cilium assembly (GO:0044458)6.63851363
19acrosome reaction (GO:0007340)6.25592709
20gene silencing by RNA (GO:0031047)6.20742752
21meiotic cell cycle (GO:0051321)6.17541098
22reproduction (GO:0000003)6.01584816
23histone H3-K9 demethylation (GO:0033169)5.81965927
24germ cell development (GO:0007281)5.33380857
25negative regulation of inclusion body assembly (GO:0090084)5.33185010
26* meiotic cell cycle process (GO:1903046)5.27377211
27single fertilization (GO:0007338)5.23800731
28regulation of cilium movement (GO:0003352)5.19643942
29* fertilization (GO:0009566)5.12294152
30spermatogenesis (GO:0007283)5.06163623
31male gamete generation (GO:0048232)5.04537989
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.04343578
33DNA methylation (GO:0006306)4.86084225
34DNA alkylation (GO:0006305)4.86084225
35cell wall macromolecule metabolic process (GO:0044036)4.83400947
36cell wall macromolecule catabolic process (GO:0016998)4.83400947
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.80954234
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.80954234
39positive regulation of mitotic sister chromatid separation (GO:1901970)4.80954234
40gamete generation (GO:0007276)4.70979067
41nuclear pore complex assembly (GO:0051292)4.70555804
42histone H3-K36 demethylation (GO:0070544)4.67872149
43monoubiquitinated protein deubiquitination (GO:0035520)4.66652665
44synapsis (GO:0007129)4.66359288
45ventricular system development (GO:0021591)4.64967018
46protein localization to cilium (GO:0061512)4.57709669
47sperm capacitation (GO:0048240)4.38134121
48nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.31805086
49regulation of DNA methylation (GO:0044030)4.27626204
50regulation of protein polyubiquitination (GO:1902914)4.21428956
51regulation of DNA endoreduplication (GO:0032875)4.20511644
52oocyte development (GO:0048599)4.20336813
53meiotic chromosome segregation (GO:0045132)4.13428543
54seminiferous tubule development (GO:0072520)4.08724204
55mitotic chromosome condensation (GO:0007076)4.06183976
56gene silencing (GO:0016458)4.03534860
57intraciliary transport (GO:0042073)4.03513952
58protein localization to chromosome (GO:0034502)4.01880255
59resolution of meiotic recombination intermediates (GO:0000712)3.98819522
60positive regulation of meiosis (GO:0045836)3.96843801
61sister chromatid cohesion (GO:0007062)3.94157591
62regulation of inclusion body assembly (GO:0090083)3.93781171
63regulation of female gonad development (GO:2000194)3.91614090
64nuclear pore organization (GO:0006999)3.90924483
65regulation of centriole replication (GO:0046599)3.87875810
66oogenesis (GO:0048477)3.87160065
67positive regulation of chromosome segregation (GO:0051984)3.86687003
68microtubule depolymerization (GO:0007019)3.86032964
69regulation of transcription from RNA polymerase I promoter (GO:0006356)3.83093903
70positive regulation of meiotic cell cycle (GO:0051446)3.79607250
71multicellular organismal reproductive process (GO:0048609)3.65575352
72DNA methylation or demethylation (GO:0044728)3.64387211
73microtubule severing (GO:0051013)3.63782557
74attachment of spindle microtubules to kinetochore (GO:0008608)3.60707865
75pore complex assembly (GO:0046931)3.59816823
76sex differentiation (GO:0007548)3.54324162
77reciprocal meiotic recombination (GO:0007131)3.53950487
78reciprocal DNA recombination (GO:0035825)3.53950487
79negative regulation of meiosis (GO:0045835)3.52477778
80negative regulation of DNA repair (GO:0045738)3.52128348
81regulation of meiotic cell cycle (GO:0051445)3.51871034
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.45869569
83negative regulation of organelle assembly (GO:1902116)3.39765770
84regulation of RNA export from nucleus (GO:0046831)3.38043521
85centrosome duplication (GO:0051298)3.37906533
86histone exchange (GO:0043486)3.36627303
87centriole replication (GO:0007099)3.35458616
88regulation of acrosome reaction (GO:0060046)3.34189689
89DNA synthesis involved in DNA repair (GO:0000731)3.33656842
90protein localization to kinetochore (GO:0034501)3.32482257
91histone lysine demethylation (GO:0070076)3.29888798
92cell recognition (GO:0008037)3.29457787
93cellular response to gamma radiation (GO:0071480)3.27142592
94axoneme assembly (GO:0035082)3.23925301
95regulation of microtubule-based movement (GO:0060632)3.22040880
96face development (GO:0060324)3.15746692
97establishment of chromosome localization (GO:0051303)3.15419170
98left/right pattern formation (GO:0060972)3.15259518
99female gamete generation (GO:0007292)3.14628827
100regulation of histone H3-K9 methylation (GO:0051570)3.14572642
101histone demethylation (GO:0016577)3.13532568
102embryonic body morphogenesis (GO:0010172)3.11353703
103retinal cone cell development (GO:0046549)3.11084316
104protein localization to chromosome, centromeric region (GO:0071459)3.08280690
105protein polyglutamylation (GO:0018095)3.05188104
106regulation of meiosis (GO:0040020)3.04890193
107regulation of cell maturation (GO:1903429)3.03780105
108mitotic metaphase plate congression (GO:0007080)3.01796712
109replicative senescence (GO:0090399)3.00468257
110protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.00317424
111positive regulation of translational initiation (GO:0045948)2.96353985
112nucleus organization (GO:0006997)2.96084258
113microtubule-based movement (GO:0007018)2.95784774
114embryonic camera-type eye development (GO:0031076)2.95331899
115mitotic sister chromatid cohesion (GO:0007064)2.94129700
116translesion synthesis (GO:0019985)2.91967903
117DNA modification (GO:0006304)2.89754168
118protein dealkylation (GO:0008214)2.87075646
119protein demethylation (GO:0006482)2.87075646
120DNA biosynthetic process (GO:0071897)2.85433850
121regulation of histone methylation (GO:0031060)2.85382033
122regulation of chromatin binding (GO:0035561)2.85069033
123positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.84333739
124regulation of sister chromatid segregation (GO:0033045)2.83871666
125regulation of mitotic sister chromatid separation (GO:0010965)2.83871666
126regulation of mitotic sister chromatid segregation (GO:0033047)2.83871666
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83675626
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83675626
129multicellular organismal development (GO:0007275)2.83601412
130metaphase plate congression (GO:0051310)2.80138535
131positive regulation of histone methylation (GO:0031062)2.79902628
132calcium ion-dependent exocytosis (GO:0017156)2.79825865
133chaperone-mediated protein complex assembly (GO:0051131)2.75158452
134negative regulation of histone methylation (GO:0031061)2.75146326
135* chromosome organization (GO:0051276)2.74795984
136chromosome segregation (GO:0007059)2.74067874
137centriole assembly (GO:0098534)2.72452659
138regulation of double-strand break repair (GO:2000779)2.71851602
139regulation of chromosome segregation (GO:0051983)2.71545054
140blastocyst development (GO:0001824)2.71455749
141lactate metabolic process (GO:0006089)2.71326347
142spindle checkpoint (GO:0031577)2.70476239
143regulation of nucleobase-containing compound transport (GO:0032239)2.70036239
144cilium organization (GO:0044782)2.69534664
145intestinal epithelial cell development (GO:0060576)2.65849432
146DNA packaging (GO:0006323)2.65201402
147positive regulation of gene expression, epigenetic (GO:0045815)2.64969398
148positive regulation of histone H3-K4 methylation (GO:0051571)2.63489794
149* nuclear division (GO:0000280)2.60737373
150negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.59881255
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59590581
152histone H4-K16 acetylation (GO:0043984)2.57401633
153piRNA metabolic process (GO:0034587)16.6712854
154cilium or flagellum-dependent cell motility (GO:0001539)13.9680300
155* male meiosis (GO:0007140)11.8339252
156* synaptonemal complex organization (GO:0070193)11.5559889
157DNA methylation involved in gamete generation (GO:0043046)11.4957370
158* synaptonemal complex assembly (GO:0007130)11.0692408
159fusion of sperm to egg plasma membrane (GO:0007342)10.1322157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.57842699
2EZH2_22144423_ChIP-Seq_EOC_Human5.33296908
3E2F7_22180533_ChIP-Seq_HELA_Human5.08073127
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.41408199
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.79690215
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.67627326
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52746825
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.63394488
9PKCTHETA_26484144_Chip-Seq_BREAST_Human2.57400759
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55572441
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55572441
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55572441
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.47098527
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.44737891
15* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.39515311
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38336893
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.37657044
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33849045
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32568402
20AHR_22903824_ChIP-Seq_MCF-7_Human2.31279608
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.23466407
22* FOXM1_26456572_ChIP-Seq_MCF-7_Human2.20769605
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16974935
24GATA1_26923725_Chip-Seq_HPCs_Mouse2.09041177
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.00946356
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.00859366
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.0325513
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96610155
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90998725
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89888389
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84424574
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81305962
33* RNF2_27304074_Chip-Seq_NSC_Mouse1.79912379
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.76878894
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76414024
36ELF5_23300383_ChIP-Seq_T47D_Human1.76283718
37ZNF274_21170338_ChIP-Seq_K562_Hela1.76029252
38* ARNT_22903824_ChIP-Seq_MCF-7_Human1.74646710
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70536454
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.64920091
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63866368
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.62813455
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61605120
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.56051657
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52890937
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52637114
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48487460
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46828114
49* RUNX1_27514584_Chip-Seq_MCF-7_Human1.46777447
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46324668
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.44216332
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42541750
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42291905
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39422223
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39422223
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.38221772
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36848323
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.34134623
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32545711
60BCAT_22108803_ChIP-Seq_LS180_Human1.31824423
61HOXB7_26014856_ChIP-Seq_BT474_Human1.30905346
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.30616328
63RUNX1_26923725_Chip-Seq_HPCs_Mouse1.28872212
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26884413
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26055746
66KDM5A_27292631_Chip-Seq_BREAST_Human1.25594063
67TCF4_23295773_ChIP-Seq_U87_Human1.25295464
68VDR_22108803_ChIP-Seq_LS180_Human1.23502355
69* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22940568
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22226832
71STAT1_17558387_ChIP-Seq_HELA_Human1.21799758
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21410719
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20932257
74GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20716336
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.19374502
76* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18657866
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.18149097
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16695451
79CBP_20019798_ChIP-Seq_JUKART_Human1.16251975
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16251975
81HTT_18923047_ChIP-ChIP_STHdh_Human1.15656311
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.15175349
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14492035
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13375961
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13030818
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11356647
87* OCT4_18555785_Chip-Seq_ESCs_Mouse1.10829433
88AR_25329375_ChIP-Seq_VCAP_Human1.10827956
89AR_21909140_ChIP-Seq_LNCAP_Human1.10452373
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10231673
91* STAT3_18555785_Chip-Seq_ESCs_Mouse1.10094297
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09230129
93ER_23166858_ChIP-Seq_MCF-7_Human1.07584862
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07121841
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07078277
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06738324
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06474122
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.05453520
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.04599443
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04391557
101FOXA1_25552417_ChIP-Seq_VCAP_Human1.04314734
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04285337
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03970129
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03910469
105KLF5_25053715_ChIP-Seq_YYC3_Human1.01648233
106* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01603993
107* KDM2B_26808549_Chip-Seq_REH_Human1.01542629
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00246735
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00109122
110* P300_18555785_Chip-Seq_ESCs_Mouse0.99729188
111OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98851250
112* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98739737
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.97958043
114* KLF4_18555785_Chip-Seq_ESCs_Mouse0.97832695
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97623598
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.97323986
117* P53_22387025_ChIP-Seq_ESCs_Mouse0.97300237
118TAF15_26573619_Chip-Seq_HEK293_Human0.96969334
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96329709
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96264757
121EWS_26573619_Chip-Seq_HEK293_Human0.96096037
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95629616
123STAT3_23295773_ChIP-Seq_U87_Human0.94661445
124* E2F1_18555785_Chip-Seq_ESCs_Mouse0.94020514
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93611104
126GATA3_26560356_Chip-Seq_TH1_Human0.92647896
127FUS_26573619_Chip-Seq_HEK293_Human0.92454938
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92442817
129FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92348226
130CDX2_22108803_ChIP-Seq_LS180_Human0.92061598
131* CMYC_18555785_Chip-Seq_ESCs_Mouse0.91722726
132* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91359861
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89939492
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.89898043
135GF1_26923725_Chip-Seq_HPCs_Mouse0.89888673
136TBL1_22424771_ChIP-Seq_293T_Human0.89840538
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.89434747
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89168686
139CTCF_18555785_Chip-Seq_ESCs_Mouse0.88627869
140E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87478084
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85645343
142* REST_21632747_ChIP-Seq_MESCs_Mouse0.85061509
143NFYB_21822215_ChIP-Seq_K562_Human0.84988012
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.84808155
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84443621
146SMAD4_21799915_ChIP-Seq_A2780_Human0.84028668
147SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83942666
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.83552292
149TFEB_21752829_ChIP-Seq_HELA_Human0.82729821
150CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81857281
151TP53_22573176_ChIP-Seq_HFKS_Human0.81026657
152GATA6_25053715_ChIP-Seq_YYC3_Human0.80316963
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79969977
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.79743001
155FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79680505
156FOXA1_25329375_ChIP-Seq_VCAP_Human0.79680505
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77227491
158ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75424999
159* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74650477
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74598426
161TP53_16413492_ChIP-PET_HCT116_Human0.73294423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.83620902
2MP0008877_abnormal_DNA_methylation9.28583464
3* MP0001929_abnormal_gametogenesis5.27164593
4* MP0003698_abnormal_male_reproductive5.15445933
5* MP0002210_abnormal_sex_determination4.70393090
6MP0008057_abnormal_DNA_replication4.58400519
7* MP0001145_abnormal_male_reproductive3.82049308
8* MP0000653_abnormal_sex_gland3.41259221
9MP0010234_abnormal_vibrissa_follicle3.39866816
10MP0008995_early_reproductive_senescence3.36781019
11* MP0002161_abnormal_fertility/fecundity2.86751754
12MP0002653_abnormal_ependyma_morphology2.85439213
13MP0003786_premature_aging2.64766069
14MP0003183_abnormal_peptide_metabolism2.63213002
15MP0010678_abnormal_skin_adnexa2.60367197
16MP0000383_abnormal_hair_follicle2.60053540
17MP0004381_abnormal_hair_follicle2.50309724
18MP0008789_abnormal_olfactory_epithelium2.48225417
19MP0004264_abnormal_extraembryonic_tissu2.35166146
20MP0010094_abnormal_chromosome_stability2.27883907
21MP0005075_abnormal_melanosome_morpholog2.25988173
22MP0008058_abnormal_DNA_repair2.21275871
23MP0000015_abnormal_ear_pigmentation2.19784675
24MP0000372_irregular_coat_pigmentation2.09203673
25MP0005409_darkened_coat_color2.02980934
26MP0010030_abnormal_orbit_morphology2.02025060
27MP0002160_abnormal_reproductive_system1.99281426
28MP0003136_yellow_coat_color1.98593952
29MP0005377_hearing/vestibular/ear_phenot1.95185558
30MP0003878_abnormal_ear_physiology1.95185558
31MP0005408_hypopigmentation1.93858514
32MP0005623_abnormal_meninges_morphology1.90144802
33MP0008007_abnormal_cellular_replicative1.87648868
34MP0002796_impaired_skin_barrier1.73559388
35MP0005394_taste/olfaction_phenotype1.66964460
36MP0005499_abnormal_olfactory_system1.66964460
37MP0005174_abnormal_tail_pigmentation1.63189822
38MP0005647_abnormal_sex_gland1.60750546
39MP0003646_muscle_fatigue1.60257802
40MP0002098_abnormal_vibrissa_morphology1.55169382
41MP0005171_absent_coat_pigmentation1.47541699
42MP0000678_abnormal_parathyroid_gland1.46612689
43MP0000377_abnormal_hair_follicle1.33780033
44MP0005248_abnormal_Harderian_gland1.32939393
45MP0003111_abnormal_nucleus_morphology1.21750541
46MP0004134_abnormal_chest_morphology1.20006037
47MP0000627_abnormal_mammary_gland1.19911439
48MP0001119_abnormal_female_reproductive1.18337105
49MP0000371_diluted_coat_color1.17280712
50MP0001919_abnormal_reproductive_system1.15796281
51MP0000427_abnormal_hair_cycle1.15793760
52MP0002234_abnormal_pharynx_morphology1.11974311
53MP0009046_muscle_twitch1.11063950
54MP0003077_abnormal_cell_cycle1.09727774
55MP0004185_abnormal_adipocyte_glucose1.09026643
56MP0000569_abnormal_digit_pigmentation1.08350633
57MP0001324_abnormal_eye_pigmentation1.05761674
58MP0005389_reproductive_system_phenotype1.03700323
59MP0002095_abnormal_skin_pigmentation1.01871009
60MP0002009_preneoplasia1.00111522
61MP0010307_abnormal_tumor_latency0.99666020
62MP0009780_abnormal_chondrocyte_physiolo0.98418144
63MP0002396_abnormal_hematopoietic_system0.95607632
64MP0002877_abnormal_melanocyte_morpholog0.93028203
65MP0004808_abnormal_hematopoietic_stem0.92178231
66* MP0003699_abnormal_female_reproductive0.91004800
67MP0002282_abnormal_trachea_morphology0.89650879
68MP0005501_abnormal_skin_physiology0.89032984
69MP0003941_abnormal_skin_development0.85776274
70MP0003787_abnormal_imprinting0.82926953
71MP0003123_paternal_imprinting0.77670948
72MP0001730_embryonic_growth_arrest0.77271345
73MP0001873_stomach_inflammation0.76567736
74MP0002102_abnormal_ear_morphology0.73098942
75MP0002089_abnormal_postnatal_growth/wei0.72647870
76MP0003943_abnormal_hepatobiliary_system0.72527354
77MP0001346_abnormal_lacrimal_gland0.71516419
78MP0003879_abnormal_hair_cell0.69913187
79MP0000762_abnormal_tongue_morphology0.68586897
80MP0001727_abnormal_embryo_implantation0.68373104
81MP0003453_abnormal_keratinocyte_physiol0.68272529
82MP0003693_abnormal_embryo_hatching0.67040695
83MP0001216_abnormal_epidermal_layer0.66873686
84MP0005503_abnormal_tendon_morphology0.65926592
85MP0000733_abnormal_muscle_development0.65461616
86MP0001984_abnormal_olfaction0.65330878
87MP0002249_abnormal_larynx_morphology0.64592296
88MP0002751_abnormal_autonomic_nervous0.63621571
89MP0001661_extended_life_span0.63265142
90MP0002108_abnormal_muscle_morphology0.62230882
91MP0004957_abnormal_blastocyst_morpholog0.61358201
92MP0000647_abnormal_sebaceous_gland0.61351584
93MP0005646_abnormal_pituitary_gland0.60281386
94MP0003119_abnormal_digestive_system0.59674046
95MP0006292_abnormal_olfactory_placode0.59318101
96MP0001664_abnormal_digestion0.59040586
97MP0004233_abnormal_muscle_weight0.59017721
98MP0003890_abnormal_embryonic-extraembry0.58541936
99MP0002166_altered_tumor_susceptibility0.57704426
100MP0001881_abnormal_mammary_gland0.57269763
101MP0000470_abnormal_stomach_morphology0.56558331
102MP0009278_abnormal_bone_marrow0.55808702
103MP0003936_abnormal_reproductive_system0.55462630
104MP0003045_fibrosis0.55081741
105MP0003950_abnormal_plasma_membrane0.54186092
106MP0001545_abnormal_hematopoietic_system0.52128511
107MP0005397_hematopoietic_system_phenotyp0.52128511
108MP0005670_abnormal_white_adipose0.50756218
109MP0002084_abnormal_developmental_patter0.49897871
110MP0003115_abnormal_respiratory_system0.49760866
111MP0003718_maternal_effect0.48597659
112MP0003121_genomic_imprinting0.48084509
113MP0000313_abnormal_cell_death0.47650468
114MP0001440_abnormal_grooming_behavior0.45625153
115MP0006138_congestive_heart_failure0.45182464
116MP0008932_abnormal_embryonic_tissue0.44181203
117MP0005076_abnormal_cell_differentiation0.43350285
118MP0001672_abnormal_embryogenesis/_devel0.41460339
119MP0005380_embryogenesis_phenotype0.41460339
120MP0004885_abnormal_endolymph0.41276468
121MP0003861_abnormal_nervous_system0.40989263
122MP0000358_abnormal_cell_content/0.40388269
123MP0002085_abnormal_embryonic_tissue0.39221243
124MP0004036_abnormal_muscle_relaxation0.39185300
125MP0001293_anophthalmia0.38482106
126MP0004270_analgesia0.38264350
127MP0001697_abnormal_embryo_size0.38202767
128MP0009672_abnormal_birth_weight0.38104125
129MP0001851_eye_inflammation0.37494784
130MP0009703_decreased_birth_body0.37384870
131MP0001765_abnormal_ion_homeostasis0.37081247
132MP0004197_abnormal_fetal_growth/weight/0.37040688
133MP0000778_abnormal_nervous_system0.33966145
134MP0000350_abnormal_cell_proliferation0.32160685
135MP0002152_abnormal_brain_morphology0.32057849
136MP0004742_abnormal_vestibular_system0.30825689
137MP0003984_embryonic_growth_retardation0.30795833
138MP0002971_abnormal_brown_adipose0.30384452
139MP0000432_abnormal_head_morphology0.29728001
140MP0005391_vision/eye_phenotype0.29316183
141MP0005395_other_phenotype0.28998229
142MP0002928_abnormal_bile_duct0.27913010
143MP0005253_abnormal_eye_physiology0.27716913
144MP0005551_abnormal_eye_electrophysiolog0.26958922
145MP0003937_abnormal_limbs/digits/tail_de0.26840735
146MP0002233_abnormal_nose_morphology0.26837273
147MP0000639_abnormal_adrenal_gland0.26773160
148MP0002088_abnormal_embryonic_growth/wei0.26406047
149MP0000751_myopathy0.26018505
150MP0002080_prenatal_lethality0.25521131
151MP0002092_abnormal_eye_morphology0.23907833
152MP0006072_abnormal_retinal_apoptosis0.23885589
153MP0005666_abnormal_adipose_tissue0.23564194
154MP0003632_abnormal_nervous_system0.22516820
155MP0002970_abnormal_white_adipose0.21552863

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.96984451
2Abnormal respiratory epithelium morphology (HP:0012253)6.91230156
3Abnormal respiratory motile cilium morphology (HP:0005938)6.91230156
4Rhinitis (HP:0012384)6.86329948
5Abnormal ciliary motility (HP:0012262)6.47043531
6Abnormality of the lower motor neuron (HP:0002366)6.28696266
7Chronic bronchitis (HP:0004469)5.92042527
8Lip pit (HP:0100267)5.73673800
9Infertility (HP:0000789)5.45371997
10Gonadotropin excess (HP:0000837)4.97259093
11Nasal polyposis (HP:0100582)4.94843495
12Volvulus (HP:0002580)4.74864047
13Nephronophthisis (HP:0000090)4.73978895
14Facial hemangioma (HP:0000329)4.61300289
15Chromsome breakage (HP:0040012)4.60765155
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.53538221
17Azoospermia (HP:0000027)4.48415636
18Amyotrophic lateral sclerosis (HP:0007354)4.46843337
19Fibular hypoplasia (HP:0003038)4.32936223
20Abnormal spermatogenesis (HP:0008669)4.24933149
21Oligodactyly (hands) (HP:0001180)4.24324490
2211 pairs of ribs (HP:0000878)4.10333531
23Abnormality of the nasal mucosa (HP:0000433)4.02421384
24Bronchiectasis (HP:0002110)3.94129896
25Male infertility (HP:0003251)3.76642620
26Upper motor neuron abnormality (HP:0002127)3.70104430
27Abnormality of the renal medulla (HP:0100957)3.66348716
28Enlarged penis (HP:0000040)3.54046268
29Bronchitis (HP:0012387)3.49291699
30Tubulointerstitial nephritis (HP:0001970)3.42064983
31Concave nail (HP:0001598)3.30505026
32Truncal obesity (HP:0001956)3.13610459
33Capillary hemangiomas (HP:0005306)3.08017337
34Degeneration of anterior horn cells (HP:0002398)3.08013732
35Abnormality of the anterior horn cell (HP:0006802)3.08013732
36Osteomalacia (HP:0002749)3.07711435
37Horizontal nystagmus (HP:0000666)2.94253869
38Generalized hypopigmentation of hair (HP:0011358)2.93759652
39Selective tooth agenesis (HP:0001592)2.92714451
40Impaired proprioception (HP:0010831)2.89546923
41Sparse lateral eyebrow (HP:0005338)2.89527063
42Oligodactyly (HP:0012165)2.89294571
43Ependymoma (HP:0002888)2.85540686
44Aplasia/Hypoplasia of the fibula (HP:0006492)2.83785870
45Astrocytoma (HP:0009592)2.75751402
46Abnormality of the astrocytes (HP:0100707)2.75751402
47Abnormality of midbrain morphology (HP:0002418)2.74183968
48Molar tooth sign on MRI (HP:0002419)2.74183968
49Fair hair (HP:0002286)2.70635441
50Supernumerary spleens (HP:0009799)2.68696340
51Medial flaring of the eyebrow (HP:0010747)2.66876356
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.66836437
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.66836437
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.65896909
55Abnormality of chromosome segregation (HP:0002916)2.65848519
56Recurrent otitis media (HP:0000403)2.65400437
57Tubular atrophy (HP:0000092)2.64608765
58Deep philtrum (HP:0002002)2.61695446
59Abnormality of chromosome stability (HP:0003220)2.60173251
60Tubulointerstitial abnormality (HP:0001969)2.59861035
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.53319124
62Hypoplasia of the fovea (HP:0007750)2.53319124
63Microglossia (HP:0000171)2.52395474
64Postaxial foot polydactyly (HP:0001830)2.48543417
65Recurrent sinusitis (HP:0011108)2.48431198
66Increased nuchal translucency (HP:0010880)2.44724059
67Severe Myopia (HP:0011003)2.44213373
68Aplasia/Hypoplasia of the macula (HP:0008059)2.44180687
69Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.43759152
70Large eyes (HP:0001090)2.43227339
71Abnormal auditory evoked potentials (HP:0006958)2.42586879
72Abnormality of the preputium (HP:0100587)2.39090036
73Abnormality of the phalanges of the hallux (HP:0010057)2.37076705
74Abnormality of the fovea (HP:0000493)2.36738014
75Spontaneous abortion (HP:0005268)2.36304364
76Stage 5 chronic kidney disease (HP:0003774)2.35066050
77Impulsivity (HP:0100710)2.33382660
78Ocular albinism (HP:0001107)2.33151905
79Anterior segment dysgenesis (HP:0007700)2.33102537
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.31921606
81Duodenal stenosis (HP:0100867)2.31637126
82Small intestinal stenosis (HP:0012848)2.31637126
83Missing ribs (HP:0000921)2.28094823
84Median cleft lip (HP:0000161)2.27012684
85Glioma (HP:0009733)2.26759059
86Conjunctival telangiectasia (HP:0000524)2.24174198
87Short ribs (HP:0000773)2.20302261
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.19532496
89Aplasia/Hypoplasia affecting the retina (HP:0008061)2.19234293
90Breast carcinoma (HP:0003002)2.17012186
91Pili torti (HP:0003777)2.11544945
92Ankle contracture (HP:0006466)2.10244157
93Non-midline cleft lip (HP:0100335)2.10034226
94Hypoplastic labia majora (HP:0000059)2.09726180
95Iris hypopigmentation (HP:0007730)2.09490141
96Blepharitis (HP:0000498)2.08932642
97Facial cleft (HP:0002006)2.08077224
98Dysdiadochokinesis (HP:0002075)2.05718133
99Absent frontal sinuses (HP:0002688)2.05162790
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.04132529
101Underdeveloped nasal alae (HP:0000430)2.03878031
102Cafe-au-lait spot (HP:0000957)2.02323676
103Oculomotor apraxia (HP:0000657)2.01882330
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8395686
105Dynein arm defect of respiratory motile cilia (HP:0012255)10.2637353
106Absent/shortened dynein arms (HP:0200106)10.2637353
107Abnormality of nail color (HP:0100643)1.99954013
108Congenital hepatic fibrosis (HP:0002612)1.99673927
109Stillbirth (HP:0003826)1.98327930
110Blue irides (HP:0000635)1.97975903
111Abnormality of abdominal situs (HP:0011620)1.97615254
112Abdominal situs inversus (HP:0003363)1.97615254
113Absent radius (HP:0003974)1.96822115
114Metaphyseal cupping (HP:0003021)1.96573182
115Abnormal lung lobation (HP:0002101)1.96157834
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.95912203
117Clubbing of toes (HP:0100760)1.95577876
118Renal dysplasia (HP:0000110)1.95431308
119Abnormality of the corticospinal tract (HP:0002492)1.95071864
120Short tibia (HP:0005736)1.94542919
121Type I transferrin isoform profile (HP:0003642)1.94199625
122Septate vagina (HP:0001153)1.91426742
123Short thumb (HP:0009778)1.91394839
124Meckel diverticulum (HP:0002245)1.91293815
125Neurodegeneration (HP:0002180)1.91194167
126Abnormality of the renal cortex (HP:0011035)1.90617405
127Flat acetabular roof (HP:0003180)1.90449659
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90128186
129Abnormality of dentin (HP:0010299)1.88744367
130Recurrent bronchitis (HP:0002837)1.87457814
131Papillary thyroid carcinoma (HP:0002895)1.87161972
132Abnormality of the ileum (HP:0001549)1.86907677
133Hypopigmentation of the fundus (HP:0007894)1.85857046
134Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.85515725
135Hypophosphatemic rickets (HP:0004912)1.85349987
136Hypoplasia of the iris (HP:0007676)1.84407520
137Cholecystitis (HP:0001082)1.83700033
138Abnormal gallbladder physiology (HP:0012438)1.83700033
139Cone-rod dystrophy (HP:0000548)1.83135568
140Abnormality of the labia majora (HP:0012881)1.81881869
141Postaxial hand polydactyly (HP:0001162)1.80314948
142Tubulointerstitial fibrosis (HP:0005576)1.79675392
143Gaze-evoked nystagmus (HP:0000640)1.78980388
144Heterotopia (HP:0002282)1.78821365
145Absent forearm bone (HP:0003953)1.78017763
146Aplasia involving forearm bones (HP:0009822)1.78017763
147Freckling (HP:0001480)1.77163332
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76838897
149Abnormal protein N-linked glycosylation (HP:0012347)1.76838897
150Abnormal protein glycosylation (HP:0012346)1.76838897
151Abnormal glycosylation (HP:0012345)1.76838897
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.76085382
153Short thorax (HP:0010306)1.75935400
154Abnormal finger flexion creases (HP:0006143)1.75801158
155Nephroblastoma (Wilms tumor) (HP:0002667)1.74969500
156Hypokinesia (HP:0002375)1.74187801
157Polydipsia (HP:0001959)1.73278061
158Abnormal drinking behavior (HP:0030082)1.73278061
159J-shaped sella turcica (HP:0002680)1.72990601
160Pancreatic fibrosis (HP:0100732)1.72774392
161Abnormality of permanent molar morphology (HP:0011071)1.70333489
162Abnormality of the dental root (HP:0006486)1.70333489
163Taurodontia (HP:0000679)1.70333489
164Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.68854330
165Dislocated radial head (HP:0003083)1.68524163
166Abnormality of the epiphyses of the hand (HP:0005924)1.65230772
167Abnormality of ocular smooth pursuit (HP:0000617)1.64335722
168Congenital primary aphakia (HP:0007707)1.63429962
169Decreased motor nerve conduction velocity (HP:0003431)1.62537505
170Gait imbalance (HP:0002141)1.62465067
171Ridged nail (HP:0001807)1.61648979
172Abnormality of the vasculature of the conjunctiva (HP:0008054)1.61568775
173Abnormality of molar (HP:0011077)1.60764417
174Abnormality of molar morphology (HP:0011070)1.60764417
175Embryonal renal neoplasm (HP:0011794)1.60409610
176Abnormality of the radial head (HP:0003995)1.58448827
177Abnormality of the dental pulp (HP:0006479)1.57358699
178Ectopic kidney (HP:0000086)1.56510092
179Poor coordination (HP:0002370)1.55780462
180Hypoplasia of dental enamel (HP:0006297)1.53067083
181Cystic liver disease (HP:0006706)1.52601529
182Pachygyria (HP:0001302)1.48127773
183Male pseudohermaphroditism (HP:0000037)1.47151454
184Sloping forehead (HP:0000340)1.46760819
185Clonus (HP:0002169)1.46552986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.11442681
2PDK49.11442681
3PDK25.79605923
4MET4.80886976
5TRIM283.96907169
6MAP3K92.92815250
7MAP3K132.74381865
8CDC72.60281636
9PRKD32.49363408
10PNCK2.41683849
11PTK2B2.36461074
12WNK42.34374688
13STK392.34319312
14ICK2.17446905
15MST1R2.14390831
16NEK22.14153277
17OXSR12.12404620
18TESK12.11517396
19PRKCI2.10355939
20ARAF1.83879894
21EIF2AK31.81562080
22CDK121.75625547
23TRIB31.73062612
24TNK21.61046887
25MATK1.60630886
26PTK21.54094666
27FER1.45956062
28WNK11.42026844
29TYRO31.41282811
30SIK31.36795309
31BMPR21.33947388
32FGR1.31834713
33EPHA21.31517661
34STK31.28276838
35EIF2AK11.28251587
36CSF1R1.27276946
37BMX1.25456515
38NEK91.25114532
39KSR11.19375046
40STK241.17128500
41MAPKAPK31.17066677
42WEE11.15584797
43PLK41.10733751
44MAP3K41.10149106
45TTK1.06496335
46PKN21.03848606
47CCNB11.03357789
48AURKA1.00137133
49ATR0.98318012
50MST40.93352744
51STK380.91633346
52ERBB30.91388833
53CHEK10.89960043
54WNK30.88745427
55ERBB20.85610701
56RAF10.85168800
57RPS6KB20.84653821
58MAP3K30.83265330
59MAP3K20.82273720
60STK38L0.79451872
61ACVR1B0.76508543
62MAPK150.75305384
63NME10.74952884
64PLK10.74353873
65TAOK30.73822868
66YES10.72783810
67MUSK0.71599663
68MAP2K70.67042010
69CHEK20.67026568
70ATM0.65634803
71LATS10.65604432
72EGFR0.65248152
73CHUK0.64243676
74CAMK1G0.58547694
75PINK10.57278112
76CDK90.56699101
77KSR20.56687962
78PDK10.56572319
79PASK0.56327119
80SCYL20.55953688
81FRK0.54165240
82BMPR1B0.53932372
83SIK10.45079385
84LMTK20.42425853
85MTOR0.38888139
86NTRK20.38449570
87DYRK30.38339674
88PAK60.36311025
89PRKAA10.35170921
90MAP3K60.34945559
91BRD40.34893053
92PIM10.32333766
93DMPK0.31825483
94GRK60.30081300
95CDK10.29490183
96MAPK130.29098650
97CDK70.28185992
98MAP2K10.27522670
99AKT20.27188862
100LATS20.26779886
101CDK20.26722429
102CDK30.26421279
103NUAK10.26260045
104BRAF0.25557844
105SRPK10.25493056
106BRSK20.24110679
107MOS0.22952773
108PRKD10.22633175
109TAOK10.19721421
110DYRK1B0.18961168
111PRKDC0.18929333
112GSK3B0.17259307
113CSNK1D0.17094042
114RPS6KB10.16787997
115PLK20.16699888
116EEF2K0.16698386
117TNIK0.15708526
118MAPK100.15195495
119MAPK80.14230248
120MAP2K40.13613159
121PRKACB0.13310779
122AKT30.11908238
123CDK40.11040839
124PAK10.11018055
125MELK0.10976345
126PDGFRB0.10138878
127STK110.09921684
128AURKB0.09428517
129PAK20.09138881
130BUB10.09087456
131NEK60.08916015
132MAPK140.08662945
133PRKCG0.07568699
134ERBB40.07140082
135MARK30.06882969
136RPS6KA30.06402267
137MAPK10.06198186
138CSNK1E0.05185419
139IRAK10.04867928
140PLK30.04527389
141STK40.03535214
142BRSK10.02281499
143SGK10.02197089
144CDC42BPA0.02163931
145RET0.02122484
146SGK20.01750761
147CSNK2A10.01625511
148CSNK2A20.01547059
149DYRK1A0.01510953
150PRKG10.00502304
151BCR0.00410453
152AKT10.00069472

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.98680348
2Vitamin B6 metabolism_Homo sapiens_hsa007504.30938802
3Basal transcription factors_Homo sapiens_hsa030224.10682753
4Fanconi anemia pathway_Homo sapiens_hsa034603.88728812
5Pyruvate metabolism_Homo sapiens_hsa006203.58370100
6Oocyte meiosis_Homo sapiens_hsa041142.70575632
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.57971871
8Pentose phosphate pathway_Homo sapiens_hsa000302.48148967
9Caffeine metabolism_Homo sapiens_hsa002322.43404508
10Propanoate metabolism_Homo sapiens_hsa006402.39830025
11Homologous recombination_Homo sapiens_hsa034402.38873318
12Fatty acid biosynthesis_Homo sapiens_hsa000612.35718021
13RNA transport_Homo sapiens_hsa030132.33634361
14Selenocompound metabolism_Homo sapiens_hsa004502.32732015
15mRNA surveillance pathway_Homo sapiens_hsa030152.32637072
16Glucagon signaling pathway_Homo sapiens_hsa049222.31817028
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00001460
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98558198
19Linoleic acid metabolism_Homo sapiens_hsa005911.89507068
20Cell cycle_Homo sapiens_hsa041101.89204395
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79166052
22Glycerolipid metabolism_Homo sapiens_hsa005611.67735121
23Huntingtons disease_Homo sapiens_hsa050161.58950063
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.58941103
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53582928
26ErbB signaling pathway_Homo sapiens_hsa040121.52134444
27Endometrial cancer_Homo sapiens_hsa052131.50103223
28Prostate cancer_Homo sapiens_hsa052151.46222755
29RNA degradation_Homo sapiens_hsa030181.42987002
30Small cell lung cancer_Homo sapiens_hsa052221.37008858
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30454483
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29249833
33Non-small cell lung cancer_Homo sapiens_hsa052231.28535252
34mTOR signaling pathway_Homo sapiens_hsa041501.26282326
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.23425385
36Thyroid cancer_Homo sapiens_hsa052161.21819106
37Regulation of autophagy_Homo sapiens_hsa041401.20336004
38Amphetamine addiction_Homo sapiens_hsa050311.18099867
39Pancreatic cancer_Homo sapiens_hsa052121.16642073
40Ether lipid metabolism_Homo sapiens_hsa005651.15929923
41Choline metabolism in cancer_Homo sapiens_hsa052311.13333433
42Adherens junction_Homo sapiens_hsa045201.10857102
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10643128
44Antigen processing and presentation_Homo sapiens_hsa046121.07829981
45Renin secretion_Homo sapiens_hsa049241.05718174
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98780524
47Long-term potentiation_Homo sapiens_hsa047200.89331603
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88083235
49p53 signaling pathway_Homo sapiens_hsa041150.87818791
50Estrogen signaling pathway_Homo sapiens_hsa049150.86473789
51PPAR signaling pathway_Homo sapiens_hsa033200.83571539
52Chronic myeloid leukemia_Homo sapiens_hsa052200.82667999
53Spliceosome_Homo sapiens_hsa030400.80850411
54Purine metabolism_Homo sapiens_hsa002300.79105173
55Nucleotide excision repair_Homo sapiens_hsa034200.77707558
56Carbon metabolism_Homo sapiens_hsa012000.77031359
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.75630388
58Lysine degradation_Homo sapiens_hsa003100.75568268
59FoxO signaling pathway_Homo sapiens_hsa040680.75092632
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75014534
61Renal cell carcinoma_Homo sapiens_hsa052110.74851539
62Biosynthesis of amino acids_Homo sapiens_hsa012300.74716105
63Glioma_Homo sapiens_hsa052140.72811551
64Olfactory transduction_Homo sapiens_hsa047400.72634044
65Fatty acid metabolism_Homo sapiens_hsa012120.71958974
66Acute myeloid leukemia_Homo sapiens_hsa052210.71616479
67MicroRNAs in cancer_Homo sapiens_hsa052060.71552583
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70674808
69Proteoglycans in cancer_Homo sapiens_hsa052050.69688951
70ABC transporters_Homo sapiens_hsa020100.67795510
71Bladder cancer_Homo sapiens_hsa052190.67461468
72Non-homologous end-joining_Homo sapiens_hsa034500.66798164
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63591566
74Insulin signaling pathway_Homo sapiens_hsa049100.63407781
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62548505
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60674276
77Prolactin signaling pathway_Homo sapiens_hsa049170.60100324
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.59990989
79Colorectal cancer_Homo sapiens_hsa052100.59072668
80Fat digestion and absorption_Homo sapiens_hsa049750.58443015
81Gap junction_Homo sapiens_hsa045400.58013708
82Melanoma_Homo sapiens_hsa052180.57974662
83Sphingolipid metabolism_Homo sapiens_hsa006000.56739895
84Hepatitis B_Homo sapiens_hsa051610.56541808
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.56067528
86Pathways in cancer_Homo sapiens_hsa052000.54600296
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54326402
88Cardiac muscle contraction_Homo sapiens_hsa042600.54250972
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54030947
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53669645
91T cell receptor signaling pathway_Homo sapiens_hsa046600.51884284
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51757278
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51621765
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51288402
95Hippo signaling pathway_Homo sapiens_hsa043900.51249027
96Folate biosynthesis_Homo sapiens_hsa007900.50571927
97Calcium signaling pathway_Homo sapiens_hsa040200.49850287
98Histidine metabolism_Homo sapiens_hsa003400.48546717
99VEGF signaling pathway_Homo sapiens_hsa043700.48049112
100Collecting duct acid secretion_Homo sapiens_hsa049660.47527298
101Melanogenesis_Homo sapiens_hsa049160.47287399
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46936403
103Synaptic vesicle cycle_Homo sapiens_hsa047210.45389594
104Influenza A_Homo sapiens_hsa051640.44363098
105Notch signaling pathway_Homo sapiens_hsa043300.42942533
106HTLV-I infection_Homo sapiens_hsa051660.42772284
107Mineral absorption_Homo sapiens_hsa049780.42766831
108AMPK signaling pathway_Homo sapiens_hsa041520.42272988
109Insulin resistance_Homo sapiens_hsa049310.41536528
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40281227
111Viral carcinogenesis_Homo sapiens_hsa052030.39814399
112Hepatitis C_Homo sapiens_hsa051600.39365620
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38919324
114Wnt signaling pathway_Homo sapiens_hsa043100.38816914
115Epstein-Barr virus infection_Homo sapiens_hsa051690.38724981
116Inositol phosphate metabolism_Homo sapiens_hsa005620.37367376
117Ovarian steroidogenesis_Homo sapiens_hsa049130.36952264
118Vitamin digestion and absorption_Homo sapiens_hsa049770.35656150
119Systemic lupus erythematosus_Homo sapiens_hsa053220.35172549
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34341668
121TGF-beta signaling pathway_Homo sapiens_hsa043500.34296654
122Herpes simplex infection_Homo sapiens_hsa051680.33622764
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.32325783
124Endocytosis_Homo sapiens_hsa041440.31667839
125Ras signaling pathway_Homo sapiens_hsa040140.30723868
126cAMP signaling pathway_Homo sapiens_hsa040240.30693276
127Pancreatic secretion_Homo sapiens_hsa049720.30190689
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30038206
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29653620
130Hedgehog signaling pathway_Homo sapiens_hsa043400.29488529
131Fructose and mannose metabolism_Homo sapiens_hsa000510.29113950
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.28857530
133Long-term depression_Homo sapiens_hsa047300.28430459
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28297773
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.27434861
136Circadian rhythm_Homo sapiens_hsa047100.27232058
137Alcoholism_Homo sapiens_hsa050340.26829707
138N-Glycan biosynthesis_Homo sapiens_hsa005100.25969856
139Tight junction_Homo sapiens_hsa045300.23785418
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23738168
141Taste transduction_Homo sapiens_hsa047420.22910468
142Glutamatergic synapse_Homo sapiens_hsa047240.22056064
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.21871950
144Toxoplasmosis_Homo sapiens_hsa051450.20273568
145Mismatch repair_Homo sapiens_hsa034300.20255288
146Salmonella infection_Homo sapiens_hsa051320.18066239
147Pyrimidine metabolism_Homo sapiens_hsa002400.17598552
148Base excision repair_Homo sapiens_hsa034100.17257151
149Dopaminergic synapse_Homo sapiens_hsa047280.16040470
150Fatty acid degradation_Homo sapiens_hsa000710.15681650
151Arachidonic acid metabolism_Homo sapiens_hsa005900.14684905
152DNA replication_Homo sapiens_hsa030300.14531496
153Axon guidance_Homo sapiens_hsa043600.13545717
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12616875
155Oxytocin signaling pathway_Homo sapiens_hsa049210.12616289
156Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12332172

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