SYCP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.96287438
2DNA methylation involved in gamete generation (GO:0043046)9.31504294
3chromosome organization involved in meiosis (GO:0070192)7.72816216
4regulation of meiosis I (GO:0060631)7.67985089
5cilium or flagellum-dependent cell motility (GO:0001539)7.27474550
6* meiotic nuclear division (GO:0007126)7.04983476
7fusion of sperm to egg plasma membrane (GO:0007342)6.71542076
8* male meiosis I (GO:0007141)6.41662973
9* meiosis I (GO:0007127)5.66165280
10acrosome assembly (GO:0001675)5.52118689
11sperm-egg recognition (GO:0035036)5.37247890
12* meiotic cell cycle process (GO:1903046)5.28474286
13spermatid development (GO:0007286)5.18122221
14binding of sperm to zona pellucida (GO:0007339)5.02819380
15multicellular organism reproduction (GO:0032504)5.00715028
16gene silencing by RNA (GO:0031047)4.97737620
17plasma membrane fusion (GO:0045026)4.97263422
18axonemal dynein complex assembly (GO:0070286)4.86628025
19sperm motility (GO:0030317)4.83414022
20cell-cell recognition (GO:0009988)4.80764982
21meiotic chromosome segregation (GO:0045132)4.68140837
22nuclear pore complex assembly (GO:0051292)4.49477178
23reciprocal meiotic recombination (GO:0007131)4.48849330
24reciprocal DNA recombination (GO:0035825)4.48849330
25meiotic cell cycle (GO:0051321)4.43870462
26DNA methylation (GO:0006306)4.38113502
27DNA alkylation (GO:0006305)4.38113502
28regulation of DNA endoreduplication (GO:0032875)4.36250877
29resolution of meiotic recombination intermediates (GO:0000712)4.25993177
30nuclear pore organization (GO:0006999)4.25835770
31protein K6-linked ubiquitination (GO:0085020)4.17631028
32oogenesis (GO:0048477)4.08938337
33cell wall macromolecule metabolic process (GO:0044036)4.06895437
34cell wall macromolecule catabolic process (GO:0016998)4.06895437
35sister chromatid cohesion (GO:0007062)4.05153144
36synapsis (GO:0007129)4.04309849
37epithelial cilium movement (GO:0003351)4.03888291
38negative regulation of meiosis (GO:0045835)4.02990387
39mitotic metaphase plate congression (GO:0007080)4.00996615
40regulation of meiotic cell cycle (GO:0051445)3.92850694
41microtubule depolymerization (GO:0007019)3.88375989
42germ cell development (GO:0007281)3.87551616
43DNA synthesis involved in DNA repair (GO:0000731)3.84030448
44reproduction (GO:0000003)3.82793352
45monoubiquitinated protein deubiquitination (GO:0035520)3.76971150
46attachment of spindle microtubules to kinetochore (GO:0008608)3.76566807
47blastocyst development (GO:0001824)3.73356662
48proteasome assembly (GO:0043248)3.72688153
49spermatogenesis (GO:0007283)3.72139153
50male gamete generation (GO:0048232)3.71973750
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.71724431
52DNA replication-dependent nucleosome organization (GO:0034723)3.67563258
53DNA replication-dependent nucleosome assembly (GO:0006335)3.67563258
54chromatin remodeling at centromere (GO:0031055)3.66527849
55regulation of centriole replication (GO:0046599)3.61928176
56negative regulation of gene silencing (GO:0060969)3.60964153
57cilium movement (GO:0003341)3.60412474
58DNA replication checkpoint (GO:0000076)3.59398991
59fertilization (GO:0009566)3.58815007
60motile cilium assembly (GO:0044458)3.56654115
61* histone exchange (GO:0043486)3.54142611
62gamete generation (GO:0007276)3.49561439
63* cellular process involved in reproduction in multicellular organism (GO:0022412)3.49118919
64regulation of cilium movement (GO:0003352)3.47920665
65pore complex assembly (GO:0046931)3.47429920
66metaphase plate congression (GO:0051310)3.46789177
67DNA methylation or demethylation (GO:0044728)3.45668310
68female gamete generation (GO:0007292)3.41764669
69gene silencing (GO:0016458)3.38157137
70acrosome reaction (GO:0007340)3.36237751
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34498388
72regulation of chromosome segregation (GO:0051983)3.33074629
73positive regulation of cellular response to oxidative stress (GO:1900409)3.29753375
74positive regulation of response to oxidative stress (GO:1902884)3.29753375
75CENP-A containing nucleosome assembly (GO:0034080)3.28087723
76single fertilization (GO:0007338)3.24318258
77kinetochore organization (GO:0051383)3.18771207
78positive regulation of meiosis (GO:0045836)3.17905072
79positive regulation of translational initiation (GO:0045948)3.16803197
80DNA replication-independent nucleosome organization (GO:0034724)3.15918311
81DNA replication-independent nucleosome assembly (GO:0006336)3.15918311
82oocyte maturation (GO:0001556)3.08555642
83chromosome organization (GO:0051276)3.08082203
84mitotic chromosome condensation (GO:0007076)3.07950466
85* nuclear division (GO:0000280)3.07277304
86histone H2A acetylation (GO:0043968)3.06342072
87behavioral response to nicotine (GO:0035095)3.05335106
88positive regulation of meiotic cell cycle (GO:0051446)3.05049029
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.04862084
90protein localization to chromosome, centromeric region (GO:0071459)3.04806036
91regulation of meiosis (GO:0040020)3.02223540
92DNA modification (GO:0006304)3.00786008
93centriole replication (GO:0007099)3.00449865
94chaperone-mediated protein complex assembly (GO:0051131)3.00148796
95purine nucleobase biosynthetic process (GO:0009113)2.98340722
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.96430656
97regulation of centrosome cycle (GO:0046605)2.96135297
98regulation of histone H3-K9 methylation (GO:0051570)2.96044405
99negative regulation of inclusion body assembly (GO:0090084)2.95206049
100negative regulation of chromosome segregation (GO:0051985)2.93084880
101regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93062521
102sulfation (GO:0051923)2.92975241
103negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92240984
104DNA biosynthetic process (GO:0071897)2.91814912
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.91595778
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91595778
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91595778
108negative regulation of sister chromatid segregation (GO:0033046)2.91595778
109reproductive system development (GO:0061458)2.91257890
110maturation of 5.8S rRNA (GO:0000460)2.90499344
111protein localization to chromosome (GO:0034502)2.86301434
112interkinetic nuclear migration (GO:0022027)2.83309593
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80749534
114mitochondrial respiratory chain complex I assembly (GO:0032981)2.80749534
115NADH dehydrogenase complex assembly (GO:0010257)2.80749534
116genitalia morphogenesis (GO:0035112)2.79441633
117negative regulation of response to food (GO:0032096)2.63164363
118negative regulation of appetite (GO:0032099)2.63164363
119double-strand break repair via homologous recombination (GO:0000724)2.59828893
120recombinational repair (GO:0000725)2.58939481
121histone H3-K9 demethylation (GO:0033169)2.55618932
122negative regulation of systemic arterial blood pressure (GO:0003085)2.54645795
123protein complex biogenesis (GO:0070271)2.48999019
124regulation of microtubule-based movement (GO:0060632)2.47889945
125negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.47635345
126sex differentiation (GO:0007548)2.46976126
127mitotic sister chromatid cohesion (GO:0007064)2.45644112
128negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.45024654
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.43157259
130water-soluble vitamin biosynthetic process (GO:0042364)2.42771980
131regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41869839
132regulation of mitotic spindle checkpoint (GO:1903504)2.41869839
133histone H3-K36 demethylation (GO:0070544)2.41312502
134negative regulation of meiotic cell cycle (GO:0051447)2.41155687
135intraciliary transport (GO:0042073)2.40938779
136microtubule anchoring (GO:0034453)2.39018640
137DNA recombination (GO:0006310)2.38747610
138indolalkylamine metabolic process (GO:0006586)2.36256678
139tryptophan catabolic process (GO:0006569)2.35950275
140indole-containing compound catabolic process (GO:0042436)2.35950275
141indolalkylamine catabolic process (GO:0046218)2.35950275
142DNA catabolic process, exonucleolytic (GO:0000738)2.34808272
143* organelle fission (GO:0048285)2.33570870
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.29929768
145somatic diversification of immune receptors via somatic mutation (GO:0002566)2.29929768
146piRNA metabolic process (GO:0034587)12.7451899
147synaptonemal complex assembly (GO:0007130)11.0463065
148synaptonemal complex organization (GO:0070193)10.7400267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.70783071
2E2F7_22180533_ChIP-Seq_HELA_Human5.25214578
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66216129
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45165667
5ZNF274_21170338_ChIP-Seq_K562_Hela3.19575791
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15402989
7EZH2_22144423_ChIP-Seq_EOC_Human3.10799120
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91575248
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90456580
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87003592
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.74345374
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59465091
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53239565
14IGF1R_20145208_ChIP-Seq_DFB_Human2.52227019
15AR_21909140_ChIP-Seq_LNCAP_Human2.49641198
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45369994
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41816203
18FUS_26573619_Chip-Seq_HEK293_Human2.38013614
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.37011309
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35230993
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.34819468
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31212703
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.29192055
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28175735
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24282759
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24263040
27EWS_26573619_Chip-Seq_HEK293_Human2.16128651
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.12518900
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09840085
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01713985
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00965538
32ER_23166858_ChIP-Seq_MCF-7_Human1.98432649
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97333336
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95705121
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93938378
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90854392
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89477824
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87854082
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86014950
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83110296
41VDR_23849224_ChIP-Seq_CD4+_Human1.82468275
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79917328
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79813595
44TAF15_26573619_Chip-Seq_HEK293_Human1.79475473
45BCAT_22108803_ChIP-Seq_LS180_Human1.75780330
46GBX2_23144817_ChIP-Seq_PC3_Human1.74487923
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70307620
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.69175152
49P300_19829295_ChIP-Seq_ESCs_Human1.67278796
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63330571
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.63106351
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.61447371
53TP53_22573176_ChIP-Seq_HFKS_Human1.59517776
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.57546225
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.56896066
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56809544
57XRN2_22483619_ChIP-Seq_HELA_Human1.51951848
58DCP1A_22483619_ChIP-Seq_HELA_Human1.51946424
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51464645
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47315674
61GABP_19822575_ChIP-Seq_HepG2_Human1.45747628
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43814209
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41863066
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41376931
65TCF4_23295773_ChIP-Seq_U87_Human1.35456828
66FOXP3_21729870_ChIP-Seq_TREG_Human1.35226780
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35034643
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34889873
69* STAT3_23295773_ChIP-Seq_U87_Human1.34120597
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33758732
71* AR_25329375_ChIP-Seq_VCAP_Human1.33236556
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.32625036
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32625036
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30217160
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30217160
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30217160
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29843888
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.29528804
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27868761
80KDM5A_27292631_Chip-Seq_BREAST_Human1.27831416
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27589689
82IRF1_19129219_ChIP-ChIP_H3396_Human1.27303979
83RUNX2_22187159_ChIP-Seq_PCA_Human1.26777312
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24194697
85SOX2_19829295_ChIP-Seq_ESCs_Human1.24055854
86NANOG_19829295_ChIP-Seq_ESCs_Human1.24055854
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24019451
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23796864
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23707212
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23510889
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23258343
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22672932
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.21483228
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20996504
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19463238
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.17725647
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17315962
98* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16735885
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16516428
100TTF2_22483619_ChIP-Seq_HELA_Human1.14731426
101* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14720144
102* CBP_20019798_ChIP-Seq_JUKART_Human1.14720144
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14612407
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14351304
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13314708
106TCF4_22108803_ChIP-Seq_LS180_Human1.12248135
107* HOXB7_26014856_ChIP-Seq_BT474_Human1.11529662
108RNF2_27304074_Chip-Seq_NSC_Mouse1.11508739
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11033449
110SMAD4_21799915_ChIP-Seq_A2780_Human1.10813587
111* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09088513
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.08889737
113AR_20517297_ChIP-Seq_VCAP_Human1.08118967
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07889154
115HTT_18923047_ChIP-ChIP_STHdh_Human1.07110338
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07005573
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04250652
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03764078
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03764078
120NCOR_22424771_ChIP-Seq_293T_Human1.02814361
121FOXH1_21741376_ChIP-Seq_EPCs_Human1.02221838
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01447249
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01062942
124ERA_21632823_ChIP-Seq_H3396_Human1.00265507
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99983014
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99551734
127CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98870230
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98452457
129* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97756813
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96498257
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.96073848
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95962244
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95240172
134GATA3_26560356_Chip-Seq_TH1_Human0.94934320
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94330069
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.94262674
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.94043080
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90436700
139GATA3_21867929_ChIP-Seq_TH1_Mouse0.89629287
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89611779
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89328394
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86040274
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85851813
144SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84828125
145SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84776239
146FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83744896
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83276246
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81696276
149SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.81144865
150MYC_18940864_ChIP-ChIP_HL60_Human0.80594216
151ELK1_19687146_ChIP-ChIP_HELA_Human0.80167159
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79139736
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79072983
154TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.77491591
155GATA3_21867929_ChIP-Seq_CD8_Mouse0.76530086
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76181021
157SRF_21415370_ChIP-Seq_HL-1_Mouse0.73134495
158STAT1_17558387_ChIP-Seq_HELA_Human0.72850554
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71691910
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71548755
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70623094
162SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70525405
163SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70212050
164ZNF263_19887448_ChIP-Seq_K562_Human0.69395308
165VDR_22108803_ChIP-Seq_LS180_Human0.69387302
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66245110
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.65818866
168HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.62790687
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.61321240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.68457618
2MP0005410_abnormal_fertilization5.91507987
3MP0008057_abnormal_DNA_replication4.35466186
4* MP0001929_abnormal_gametogenesis4.35006647
5* MP0002210_abnormal_sex_determination4.26798915
6* MP0003698_abnormal_male_reproductive3.88592108
7MP0010094_abnormal_chromosome_stability3.66405474
8MP0008995_early_reproductive_senescence3.61102919
9MP0003693_abnormal_embryo_hatching3.58672980
10* MP0001145_abnormal_male_reproductive3.52716929
11MP0003786_premature_aging3.49870003
12MP0008058_abnormal_DNA_repair3.46275439
13MP0003111_abnormal_nucleus_morphology3.23828312
14* MP0000653_abnormal_sex_gland3.17833587
15MP0004957_abnormal_blastocyst_morpholog2.74117571
16MP0003077_abnormal_cell_cycle2.64513898
17MP0003123_paternal_imprinting2.44004703
18MP0008007_abnormal_cellular_replicative2.36678340
19MP0000569_abnormal_digit_pigmentation2.34429613
20* MP0002161_abnormal_fertility/fecundity2.27835465
21MP0002653_abnormal_ependyma_morphology2.14597048
22MP0003718_maternal_effect2.10690052
23MP0005174_abnormal_tail_pigmentation1.88769709
24MP0001986_abnormal_taste_sensitivity1.78691463
25MP0008932_abnormal_embryonic_tissue1.76446827
26MP0002160_abnormal_reproductive_system1.76103693
27MP0003195_calcinosis1.75855378
28MP0003878_abnormal_ear_physiology1.73741669
29MP0005377_hearing/vestibular/ear_phenot1.73741669
30MP0000372_irregular_coat_pigmentation1.72074585
31MP0001730_embryonic_growth_arrest1.71942072
32MP0001485_abnormal_pinna_reflex1.68863389
33MP0008789_abnormal_olfactory_epithelium1.67005941
34MP0005551_abnormal_eye_electrophysiolog1.57227597
35MP0001119_abnormal_female_reproductive1.49423913
36MP0010307_abnormal_tumor_latency1.48783184
37MP0004885_abnormal_endolymph1.48005146
38MP0000678_abnormal_parathyroid_gland1.43838320
39MP0002163_abnormal_gland_morphology1.41870345
40MP0000631_abnormal_neuroendocrine_gland1.38580846
41MP0005646_abnormal_pituitary_gland1.38405719
42MP0008872_abnormal_physiological_respon1.32581041
43MP0001968_abnormal_touch/_nociception1.29333243
44MP0005389_reproductive_system_phenotype1.29216530
45MP0005623_abnormal_meninges_morphology1.28066048
46MP0001984_abnormal_olfaction1.26450785
47MP0003646_muscle_fatigue1.25051892
48MP0000350_abnormal_cell_proliferation1.22796307
49MP0002095_abnormal_skin_pigmentation1.22721373
50* MP0003699_abnormal_female_reproductive1.18367700
51MP0005647_abnormal_sex_gland1.17279716
52MP0002272_abnormal_nervous_system1.17090518
53MP0000015_abnormal_ear_pigmentation1.16980143
54MP0002876_abnormal_thyroid_physiology1.16949147
55MP0002736_abnormal_nociception_after1.16157550
56MP0001661_extended_life_span1.15238994
57MP0001672_abnormal_embryogenesis/_devel1.12350260
58MP0005380_embryogenesis_phenotype1.12350260
59MP0001188_hyperpigmentation1.11524545
60MP0009745_abnormal_behavioral_response1.08329920
61MP0001697_abnormal_embryo_size1.07417632
62MP0003315_abnormal_perineum_morphology1.05260116
63MP0002085_abnormal_embryonic_tissue1.03364291
64MP0004142_abnormal_muscle_tone1.03359923
65MP0003567_abnormal_fetal_cardiomyocyte1.03279405
66MP0002638_abnormal_pupillary_reflex1.01540539
67MP0002735_abnormal_chemical_nociception1.01529498
68MP0002837_dystrophic_cardiac_calcinosis1.00450721
69MP0002938_white_spotting0.98764161
70MP0002084_abnormal_developmental_patter0.98397437
71MP0005395_other_phenotype0.97980874
72MP0009379_abnormal_foot_pigmentation0.97815403
73MP0000049_abnormal_middle_ear0.97074719
74MP0000383_abnormal_hair_follicle0.96936229
75MP0001486_abnormal_startle_reflex0.96270735
76MP0003941_abnormal_skin_development0.96242751
77MP0000427_abnormal_hair_cycle0.95689207
78MP0004215_abnormal_myocardial_fiber0.95078726
79MP0003984_embryonic_growth_retardation0.93193988
80MP0003121_genomic_imprinting0.92363793
81MP0005499_abnormal_olfactory_system0.92289818
82MP0005394_taste/olfaction_phenotype0.92289818
83MP0001727_abnormal_embryo_implantation0.91539420
84MP0003890_abnormal_embryonic-extraembry0.91440397
85MP0005379_endocrine/exocrine_gland_phen0.91439283
86MP0005670_abnormal_white_adipose0.89752866
87MP0002088_abnormal_embryonic_growth/wei0.88967526
88MP0004742_abnormal_vestibular_system0.87751384
89MP0000313_abnormal_cell_death0.87441821
90MP0003183_abnormal_peptide_metabolism0.87367042
91MP0002080_prenatal_lethality0.86616247
92MP0003936_abnormal_reproductive_system0.86343950
93MP0006035_abnormal_mitochondrial_morpho0.85145282
94MP0002139_abnormal_hepatobiliary_system0.84993772
95MP0002277_abnormal_respiratory_mucosa0.83315338
96MP0001529_abnormal_vocalization0.82301181
97MP0005253_abnormal_eye_physiology0.81880389
98MP0004197_abnormal_fetal_growth/weight/0.77418270
99MP0002138_abnormal_hepatobiliary_system0.77396813
100MP0004147_increased_porphyrin_level0.77077038
101MP0002102_abnormal_ear_morphology0.75442600
102MP0002067_abnormal_sensory_capabilities0.75380503
103MP0002928_abnormal_bile_duct0.74424295
104MP0002064_seizures0.72975980
105MP0004133_heterotaxia0.72947884
106MP0001502_abnormal_circadian_rhythm0.70609270
107MP0001324_abnormal_eye_pigmentation0.70575305
108MP0003950_abnormal_plasma_membrane0.70564124
109MP0009672_abnormal_birth_weight0.70400146
110MP0005423_abnormal_somatic_nervous0.70139936
111MP0003938_abnormal_ear_development0.69841215
112MP0003787_abnormal_imprinting0.69509387
113MP0001919_abnormal_reproductive_system0.69007478
114MP0001963_abnormal_hearing_physiology0.68884578
115MP0004808_abnormal_hematopoietic_stem0.68737460
116MP0006292_abnormal_olfactory_placode0.68720040
117MP0000647_abnormal_sebaceous_gland0.68011818
118MP0002086_abnormal_extraembryonic_tissu0.67976196
119MP0004924_abnormal_behavior0.67210286
120MP0005386_behavior/neurological_phenoty0.67210286
121MP0005645_abnormal_hypothalamus_physiol0.65788219
122MP0001293_anophthalmia0.65229219
123MP0002019_abnormal_tumor_incidence0.64944957
124MP0009250_abnormal_appendicular_skeleto0.64667483
125MP0005084_abnormal_gallbladder_morpholo0.64286327
126MP0003937_abnormal_limbs/digits/tail_de0.63729085
127MP0002733_abnormal_thermal_nociception0.63289033
128MP0000026_abnormal_inner_ear0.62976359
129MP0004084_abnormal_cardiac_muscle0.61775161
130MP0005076_abnormal_cell_differentiation0.57763751
131MP0005666_abnormal_adipose_tissue0.55791838
132MP0000358_abnormal_cell_content/0.54001232
133MP0009703_decreased_birth_body0.51798381
134MP0010352_gastrointestinal_tract_polyps0.51716215
135MP0003879_abnormal_hair_cell0.50861195
136MP0006036_abnormal_mitochondrial_physio0.47961963
137MP0008260_abnormal_autophagy0.46631988
138MP0004233_abnormal_muscle_weight0.44486119
139MP0003861_abnormal_nervous_system0.42698023
140MP0004185_abnormal_adipocyte_glucose0.42604132
141MP0005384_cellular_phenotype0.40886965
142MP0000432_abnormal_head_morphology0.40680926
143MP0005621_abnormal_cell_physiology0.40571494
144MP0003119_abnormal_digestive_system0.40408506
145MP0002092_abnormal_eye_morphology0.35354477
146MP0006138_congestive_heart_failure0.35058036
147MP0003136_yellow_coat_color0.34582280
148MP0009046_muscle_twitch0.34171257
149MP0003221_abnormal_cardiomyocyte_apopto0.33326402
150MP0000627_abnormal_mammary_gland0.33091321
151MP0005266_abnormal_metabolism0.32692071
152MP0000428_abnormal_craniofacial_morphol0.32373355
153MP0004036_abnormal_muscle_relaxation0.32001641
154MP0002269_muscular_atrophy0.30975263
155MP0005451_abnormal_body_composition0.29938877
156MP0006072_abnormal_retinal_apoptosis0.29216712
157MP0005391_vision/eye_phenotype0.28873275
158MP0005397_hematopoietic_system_phenotyp0.28847276
159MP0001545_abnormal_hematopoietic_system0.28847276
160MP0009697_abnormal_copulation0.28770863
161MP0002233_abnormal_nose_morphology0.27962698
162MP0003186_abnormal_redox_activity0.27935309

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.04881091
2Absent/shortened dynein arms (HP:0200106)6.72403954
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.72403954
4Abnormal respiratory motile cilium physiology (HP:0012261)5.82434770
5Rhinitis (HP:0012384)5.27494133
6Abnormal respiratory motile cilium morphology (HP:0005938)4.91022599
7Abnormal respiratory epithelium morphology (HP:0012253)4.91022599
8Gonadotropin excess (HP:0000837)4.77575530
9* Abnormal spermatogenesis (HP:0008669)4.69492130
10Abnormal ciliary motility (HP:0012262)4.64271527
11Abnormality of the lower motor neuron (HP:0002366)4.63734885
12Chronic bronchitis (HP:0004469)4.61696449
13Male infertility (HP:0003251)4.30212105
14* Azoospermia (HP:0000027)4.23661119
15Infertility (HP:0000789)4.21401515
1611 pairs of ribs (HP:0000878)3.82837252
17Impulsivity (HP:0100710)3.58077871
18Nephronophthisis (HP:0000090)3.52646365
19Supernumerary spleens (HP:0009799)3.51427550
20Breast hypoplasia (HP:0003187)3.38810187
21Birth length less than 3rd percentile (HP:0003561)3.35686528
22Amyotrophic lateral sclerosis (HP:0007354)3.32313755
23Degeneration of anterior horn cells (HP:0002398)3.30385032
24Abnormality of the anterior horn cell (HP:0006802)3.30385032
25Volvulus (HP:0002580)3.27029776
26Fibular hypoplasia (HP:0003038)3.20109429
27Chromsome breakage (HP:0040012)3.18211260
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09959581
29Selective tooth agenesis (HP:0001592)3.06969238
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99599736
31Abnormality of alanine metabolism (HP:0010916)2.99599736
32Hyperalaninemia (HP:0003348)2.99599736
33Type II lissencephaly (HP:0007260)2.95662492
34Abnormality of the labia minora (HP:0012880)2.94558545
35Bronchiectasis (HP:0002110)2.88884287
36Abnormality of the renal cortex (HP:0011035)2.88116921
37Nasal polyposis (HP:0100582)2.86368806
38Carpal bone hypoplasia (HP:0001498)2.84384765
39Tongue fasciculations (HP:0001308)2.79407203
40Upper motor neuron abnormality (HP:0002127)2.77945267
41Facial cleft (HP:0002006)2.76629450
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.69981823
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69981823
44Aplasia/Hypoplasia of the fibula (HP:0006492)2.69874778
45True hermaphroditism (HP:0010459)2.69347588
46Pancreatic fibrosis (HP:0100732)2.61302407
47Abnormality of the renal medulla (HP:0100957)2.57583812
48Abnormality of midbrain morphology (HP:0002418)2.56754298
49Molar tooth sign on MRI (HP:0002419)2.56754298
50Methylmalonic acidemia (HP:0002912)2.56401179
51Bronchitis (HP:0012387)2.54686026
52Meckel diverticulum (HP:0002245)2.53361810
53Muscle fibrillation (HP:0010546)2.52068600
54Median cleft lip (HP:0000161)2.49034039
55Microglossia (HP:0000171)2.48801775
56Abnormality of chromosome stability (HP:0003220)2.48189705
57Genetic anticipation (HP:0003743)2.41943609
58Abnormal lung lobation (HP:0002101)2.40933187
59Facial hemangioma (HP:0000329)2.39715384
603-Methylglutaconic aciduria (HP:0003535)2.38595497
61Absent radius (HP:0003974)2.36255937
62Breast carcinoma (HP:0003002)2.35430909
63Abnormality of the ileum (HP:0001549)2.34577378
64Secondary amenorrhea (HP:0000869)2.33335115
65Abnormality of the preputium (HP:0100587)2.30931077
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30891323
67Cystic liver disease (HP:0006706)2.29110472
68Oligodactyly (hands) (HP:0001180)2.28679579
69Absent forearm bone (HP:0003953)2.27209712
70Aplasia involving forearm bones (HP:0009822)2.27209712
71Tubulointerstitial nephritis (HP:0001970)2.27042489
72Fair hair (HP:0002286)2.24656674
73Patellar aplasia (HP:0006443)2.23905287
74Abnormality of the renal collecting system (HP:0004742)2.23712923
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.23031520
76Pendular nystagmus (HP:0012043)2.22714800
77Gaze-evoked nystagmus (HP:0000640)2.20955863
78Congenital stationary night blindness (HP:0007642)2.20807825
79Missing ribs (HP:0000921)2.18652998
80Abnormality of DNA repair (HP:0003254)2.17700187
81Aplasia/Hypoplasia of the earlobes (HP:0009906)2.17515162
82Increased CSF lactate (HP:0002490)2.16957132
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.16114156
84Oligodactyly (HP:0012165)2.14795027
85Small hand (HP:0200055)2.14659685
86Medial flaring of the eyebrow (HP:0010747)2.14619985
87Methylmalonic aciduria (HP:0012120)2.11937415
88Postaxial foot polydactyly (HP:0001830)2.11518349
89Sloping forehead (HP:0000340)2.09664998
90Abnormality of the nasal mucosa (HP:0000433)2.09629799
91Ectopic kidney (HP:0000086)2.09204338
92Aplasia/Hypoplasia of the patella (HP:0006498)2.08506937
93Papillary thyroid carcinoma (HP:0002895)2.08023518
94Conjunctival telangiectasia (HP:0000524)2.07810953
95Atrophy/Degeneration involving motor neurons (HP:0007373)2.06939703
96Short ribs (HP:0000773)2.06178923
97Sclerocornea (HP:0000647)2.05636885
98Premature ovarian failure (HP:0008209)2.05400978
99Short tibia (HP:0005736)2.05184208
100Abnormality of the duodenum (HP:0002246)2.05128971
101Acute necrotizing encephalopathy (HP:0006965)2.04237735
102Hyperventilation (HP:0002883)2.00315471
103Ureteral duplication (HP:0000073)1.99588644
104Pancreatic cysts (HP:0001737)1.99120034
105Mitochondrial inheritance (HP:0001427)1.98877653
106Capillary hemangiomas (HP:0005306)1.98608758
107Nephroblastoma (Wilms tumor) (HP:0002667)1.96254194
108Tubular atrophy (HP:0000092)1.95498593
109Gait imbalance (HP:0002141)1.95346831
110Abolished electroretinogram (ERG) (HP:0000550)1.94190906
111Multicystic kidney dysplasia (HP:0000003)1.94043340
112Hypoplasia of the radius (HP:0002984)1.93572487
113Congenital primary aphakia (HP:0007707)1.92272233
114Progressive cerebellar ataxia (HP:0002073)1.91987694
115Hypoplasia of the pons (HP:0012110)1.91249274
116Small intestinal stenosis (HP:0012848)1.91235931
117Duodenal stenosis (HP:0100867)1.91235931
118Congenital hepatic fibrosis (HP:0002612)1.90418871
119Progressive macrocephaly (HP:0004481)1.90392970
120Horseshoe kidney (HP:0000085)1.90261748
121Impaired proprioception (HP:0010831)1.89355267
122Abnormal glycosylation (HP:0012345)1.86999714
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86999714
124Abnormal protein N-linked glycosylation (HP:0012347)1.86999714
125Abnormal protein glycosylation (HP:0012346)1.86999714
126Renal cortical cysts (HP:0000803)1.86638237
127Preaxial hand polydactyly (HP:0001177)1.86511898
128Duplicated collecting system (HP:0000081)1.86248244
129Horizontal nystagmus (HP:0000666)1.85694572
130Hepatocellular necrosis (HP:0001404)1.83590609
131Hepatic necrosis (HP:0002605)1.83520945
132Congenital, generalized hypertrichosis (HP:0004540)1.83499318
133Cerebral hypomyelination (HP:0006808)1.83127340
134Abnormality of the pons (HP:0007361)1.82145394
135Clitoromegaly (HP:0000057)1.81177951
136Nephrogenic diabetes insipidus (HP:0009806)1.80424394
137Recurrent otitis media (HP:0000403)1.79480874
138Hypothermia (HP:0002045)1.79246512
139Embryonal renal neoplasm (HP:0011794)1.78664466
140Hypoplastic iliac wings (HP:0002866)1.78579757
141Genital tract atresia (HP:0001827)1.78385349
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77396065
143Optic nerve hypoplasia (HP:0000609)1.76987959
144Oculomotor apraxia (HP:0000657)1.76565880
145Absent thumb (HP:0009777)1.76502297
146Furrowed tongue (HP:0000221)1.75728736
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75637213
148Abnormality of the corticospinal tract (HP:0002492)1.75106966
149Sandal gap (HP:0001852)1.75054495
150Astigmatism (HP:0000483)1.74618384
151Anencephaly (HP:0002323)1.74426088
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.73943352
153Rough bone trabeculation (HP:0100670)1.73610611
154Tubulointerstitial abnormality (HP:0001969)1.73567024
155Polydipsia (HP:0001959)1.73444251
156Abnormal drinking behavior (HP:0030082)1.73444251
157Concave nail (HP:0001598)1.73050335
158Widely spaced teeth (HP:0000687)1.71898668
159Scotoma (HP:0000575)1.71428768
160Attenuation of retinal blood vessels (HP:0007843)1.70444017
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70408335
162Aplasia/hypoplasia of the humerus (HP:0006507)1.69786976
163Type I transferrin isoform profile (HP:0003642)1.69288752
164Shoulder girdle muscle weakness (HP:0003547)1.68998133
165Abnormality of the clitoris (HP:0000056)1.67910994
166Male pseudohermaphroditism (HP:0000037)1.67347084
167Poor coordination (HP:0002370)1.62930848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.46496001
2PDK46.46496001
3PDK24.17756044
4WEE13.95163829
5FRK3.75126338
6CDC73.57125444
7ACVR1B2.89879174
8BUB12.85606729
9CDK192.80634925
10NEK22.63292305
11ADRBK22.57155900
12PNCK2.48028069
13OXSR12.41837924
14TTK2.40773547
15PLK42.32736875
16BMPR1B2.31245043
17SRPK12.26914449
18CDK122.22320534
19EIF2AK12.12146433
20GRK12.05090124
21BRSK21.98976475
22TLK11.96442199
23TAOK31.93502263
24STK38L1.92611881
25PLK11.82272060
26EPHA21.80171253
27PRKD31.55485141
28MAPK131.54404379
29CHEK21.48718835
30CHEK11.37007551
31NEK11.35181363
32ATR1.34620315
33TESK11.28800747
34DYRK31.25012455
35STK391.23636807
36PTK2B1.23094373
37STK31.20680408
38MET1.19859843
39CASK1.17896421
40WNK41.13521587
41PLK31.13096423
42STK161.07933824
43EIF2AK31.03533327
44BRSK11.03193577
45PINK11.01015538
46INSRR1.00772191
47MST40.99781438
48MAP4K20.99054984
49CAMK1G0.96565025
50CDK70.96434090
51ATM0.95304475
52AURKB0.94839090
53TYRO30.91532045
54CCNB10.90830656
55NEK90.90422098
56TNIK0.90252933
57WNK30.86071735
58PRKCG0.85260623
59MKNK20.84850858
60LATS20.84205810
61NTRK30.84205095
62ICK0.83111887
63AURKA0.77074806
64LATS10.74686990
65TAF10.69371939
66PRKCE0.67750740
67TIE10.67557287
68ADRBK10.65650955
69TXK0.65006840
70STK380.64922620
71MAP3K40.64725178
72NME10.64138152
73CDK20.63750130
74PBK0.63226610
75MELK0.61838311
76AKT30.61737163
77CDK10.59362890
78IRAK30.59154218
79GRK70.58689537
80BRAF0.55852862
81RPS6KB10.55171299
82SGK10.54362000
83VRK10.53099338
84CDK40.52677608
85BRD40.51873006
86PRKCI0.51633074
87CSNK1G10.51240809
88DYRK20.49540616
89STK110.49152202
90FGR0.47185906
91TSSK60.46891360
92PASK0.46744655
93MAP3K60.45812075
94CDK30.45278436
95PHKG20.44816237
96PHKG10.44816237
97CSNK2A10.44338817
98IRAK10.44312693
99TRIM280.43548377
100CSF1R0.42982734
101PKN10.42969301
102NLK0.42894261
103MAP2K70.42731926
104MARK30.42469457
105STK40.42409793
106WNK10.42343958
107CSNK2A20.42143202
108PRKG10.42043898
109CAMK10.40130221
110MAP2K60.39821798
111MKNK10.39246972
112ZAK0.38489606
113PRKCZ0.37923386
114PRKCQ0.36757138
115PAK10.35405763
116STK240.34839361
117PRKDC0.34172169
118CSNK1E0.33571816
119PAK30.32952811
120EGFR0.32750247
121IGF1R0.32143955
122CAMK2A0.32089729
123TEC0.31445840
124PRKACB0.30787744
125CSNK1G20.30060438
126MTOR0.29658423
127NEK60.29381312
128BCR0.28415733
129MAP3K20.28175747
130PRKACA0.27825258
131CSNK1A10.26920462
132TESK20.26736452
133RPS6KB20.26716129
134MAP3K80.26134383
135CDK90.25946971
136LMTK20.25658865
137PRKD20.25615635
138GSK3B0.23509782
139PLK20.21736772
140MAPK100.21661811
141PAK40.19301402
142PRKAA10.19003313
143CSNK1D0.18365684
144PDK10.16096890
145MAPK80.14934998
146MAPK140.13118783
147NUAK10.13021133
148CDK80.11985448
149EIF2AK20.11266995
150RPS6KA40.10792251
151IRAK20.10444659
152RPS6KA50.10185949

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.96744530
2Basal transcription factors_Homo sapiens_hsa030224.30973304
3RNA polymerase_Homo sapiens_hsa030203.74382275
4RNA transport_Homo sapiens_hsa030133.74077335
5Fanconi anemia pathway_Homo sapiens_hsa034603.56092449
6Proteasome_Homo sapiens_hsa030503.52270842
7Vitamin B6 metabolism_Homo sapiens_hsa007503.31818568
8Cell cycle_Homo sapiens_hsa041102.96076716
9DNA replication_Homo sapiens_hsa030302.90577270
10Spliceosome_Homo sapiens_hsa030402.75765590
11Mismatch repair_Homo sapiens_hsa034302.71168367
12mRNA surveillance pathway_Homo sapiens_hsa030152.53858824
13* Homologous recombination_Homo sapiens_hsa034402.39026653
14Pentose phosphate pathway_Homo sapiens_hsa000302.34420645
15Nucleotide excision repair_Homo sapiens_hsa034202.33423620
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.30113430
17Oocyte meiosis_Homo sapiens_hsa041142.19387266
18Pyrimidine metabolism_Homo sapiens_hsa002402.13654059
19RNA degradation_Homo sapiens_hsa030182.04843074
20Sulfur relay system_Homo sapiens_hsa041221.88865966
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71471206
22Base excision repair_Homo sapiens_hsa034101.69799052
23Phototransduction_Homo sapiens_hsa047441.68686163
24Nicotine addiction_Homo sapiens_hsa050331.67063189
25Selenocompound metabolism_Homo sapiens_hsa004501.66150717
26Purine metabolism_Homo sapiens_hsa002301.64290606
27Dorso-ventral axis formation_Homo sapiens_hsa043201.55370646
28p53 signaling pathway_Homo sapiens_hsa041151.52802269
29Pyruvate metabolism_Homo sapiens_hsa006201.52303334
30Non-homologous end-joining_Homo sapiens_hsa034501.51119572
31Huntingtons disease_Homo sapiens_hsa050161.45374057
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41242921
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40062813
34Caffeine metabolism_Homo sapiens_hsa002321.33597430
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28809511
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.28768204
37Tryptophan metabolism_Homo sapiens_hsa003801.24824293
38Butanoate metabolism_Homo sapiens_hsa006501.24555426
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23357801
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22942103
41Propanoate metabolism_Homo sapiens_hsa006401.22816944
42Alzheimers disease_Homo sapiens_hsa050101.21965719
43Nitrogen metabolism_Homo sapiens_hsa009101.18975452
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16867145
45Linoleic acid metabolism_Homo sapiens_hsa005911.16226809
46Taste transduction_Homo sapiens_hsa047421.15690494
47Epstein-Barr virus infection_Homo sapiens_hsa051691.11720575
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11171168
49One carbon pool by folate_Homo sapiens_hsa006701.10318419
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07948614
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07262248
52Biosynthesis of amino acids_Homo sapiens_hsa012301.02946709
53Collecting duct acid secretion_Homo sapiens_hsa049661.00078686
54Glycerolipid metabolism_Homo sapiens_hsa005610.98621627
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.95776321
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93286220
57Olfactory transduction_Homo sapiens_hsa047400.93020777
58Carbon metabolism_Homo sapiens_hsa012000.91275436
59Ribosome_Homo sapiens_hsa030100.87477329
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81904491
61beta-Alanine metabolism_Homo sapiens_hsa004100.78546991
62Chemical carcinogenesis_Homo sapiens_hsa052040.78389001
63ABC transporters_Homo sapiens_hsa020100.78066577
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76954246
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76591995
66Fatty acid biosynthesis_Homo sapiens_hsa000610.76037957
67Sulfur metabolism_Homo sapiens_hsa009200.74860345
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74764723
69Calcium signaling pathway_Homo sapiens_hsa040200.69187373
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67884495
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.65699739
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64529154
73Antigen processing and presentation_Homo sapiens_hsa046120.64049450
74Insulin secretion_Homo sapiens_hsa049110.62457405
75Glutathione metabolism_Homo sapiens_hsa004800.61990980
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61767125
77Morphine addiction_Homo sapiens_hsa050320.61653993
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59656594
79Peroxisome_Homo sapiens_hsa041460.58945028
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57679565
81Herpes simplex infection_Homo sapiens_hsa051680.56868947
82Glucagon signaling pathway_Homo sapiens_hsa049220.55677712
83Fructose and mannose metabolism_Homo sapiens_hsa000510.55302344
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54205152
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54179808
86Ether lipid metabolism_Homo sapiens_hsa005650.53484212
87Ovarian steroidogenesis_Homo sapiens_hsa049130.51837591
88Glutamatergic synapse_Homo sapiens_hsa047240.50886828
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48814492
90TGF-beta signaling pathway_Homo sapiens_hsa043500.48022214
91Serotonergic synapse_Homo sapiens_hsa047260.47467866
92Viral carcinogenesis_Homo sapiens_hsa052030.47286811
93Renin-angiotensin system_Homo sapiens_hsa046140.43501150
94HTLV-I infection_Homo sapiens_hsa051660.42974768
95Regulation of autophagy_Homo sapiens_hsa041400.42584822
96Metabolic pathways_Homo sapiens_hsa011000.41392969
97Vitamin digestion and absorption_Homo sapiens_hsa049770.41198961
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40837483
99Arachidonic acid metabolism_Homo sapiens_hsa005900.40626317
100Steroid biosynthesis_Homo sapiens_hsa001000.40375455
101Fat digestion and absorption_Homo sapiens_hsa049750.39027244
102Melanoma_Homo sapiens_hsa052180.39009511
103Tight junction_Homo sapiens_hsa045300.38596019
104N-Glycan biosynthesis_Homo sapiens_hsa005100.36357142
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35828703
106Systemic lupus erythematosus_Homo sapiens_hsa053220.35591057
107Lysine degradation_Homo sapiens_hsa003100.35030528
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33901649
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33580884
110Circadian entrainment_Homo sapiens_hsa047130.33219708
111Sphingolipid metabolism_Homo sapiens_hsa006000.33169144
112Mineral absorption_Homo sapiens_hsa049780.32500768
113GABAergic synapse_Homo sapiens_hsa047270.30455527
114Fatty acid degradation_Homo sapiens_hsa000710.29583558
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.28688330
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26438867
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24325205
118Hippo signaling pathway_Homo sapiens_hsa043900.22991321
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21793260
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.17581650
121Parkinsons disease_Homo sapiens_hsa050120.16903176
122Hedgehog signaling pathway_Homo sapiens_hsa043400.16382039
123Protein export_Homo sapiens_hsa030600.15587462
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15055698
125PPAR signaling pathway_Homo sapiens_hsa033200.13792312
126Influenza A_Homo sapiens_hsa051640.13498115
127Fatty acid metabolism_Homo sapiens_hsa012120.12402923
128Cardiac muscle contraction_Homo sapiens_hsa042600.11693436
129Folate biosynthesis_Homo sapiens_hsa007900.11471665
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10143394
131AMPK signaling pathway_Homo sapiens_hsa041520.09894857
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07626760
133MicroRNAs in cancer_Homo sapiens_hsa052060.06384388
134Small cell lung cancer_Homo sapiens_hsa052220.04048724
135Oxidative phosphorylation_Homo sapiens_hsa001900.01799513
136Retinol metabolism_Homo sapiens_hsa008300.01290938
137Inositol phosphate metabolism_Homo sapiens_hsa005620.00706801
138Circadian rhythm_Homo sapiens_hsa047100.00419454
139Wnt signaling pathway_Homo sapiens_hsa043100.00393296
140Arginine and proline metabolism_Homo sapiens_hsa00330-0.0555093
141FoxO signaling pathway_Homo sapiens_hsa04068-0.0427017
142Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0394828
143Endocytosis_Homo sapiens_hsa04144-0.0386794
144Adherens junction_Homo sapiens_hsa04520-0.0310295

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