SYDE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.50907866
2chondrocyte proliferation (GO:0035988)5.41649457
3collagen fibril organization (GO:0030199)5.13419215
4regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.46401768
5endodermal cell differentiation (GO:0035987)4.29044430
6sequestering of extracellular ligand from receptor (GO:0035581)4.22857778
7bone trabecula formation (GO:0060346)4.20079779
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.07168113
9axon extension involved in axon guidance (GO:0048846)4.07168113
10glomerular basement membrane development (GO:0032836)4.05533310
11type B pancreatic cell proliferation (GO:0044342)4.04387139
12basement membrane organization (GO:0071711)4.03066159
13plasma membrane repair (GO:0001778)4.01110046
14protein retention in ER lumen (GO:0006621)3.98997152
15vascular endothelial growth factor signaling pathway (GO:0038084)3.94578252
16Golgi transport vesicle coating (GO:0048200)3.92591708
17COPI coating of Golgi vesicle (GO:0048205)3.92591708
18hippo signaling (GO:0035329)3.89569793
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.87146733
20endocardial cushion development (GO:0003197)3.82725815
21wound healing, spreading of epidermal cells (GO:0035313)3.77315362
22positive regulation of endothelial cell apoptotic process (GO:2000353)3.74178712
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.73998278
24cell adhesion mediated by integrin (GO:0033627)3.67716945
25negative regulation of fatty acid transport (GO:2000192)3.65229697
26renal filtration (GO:0097205)3.62659073
27mesenchymal-epithelial cell signaling (GO:0060638)3.55125248
28paraxial mesoderm development (GO:0048339)3.50519242
29skin morphogenesis (GO:0043589)3.50073190
30regulation of tight junction assembly (GO:2000810)3.48649872
31glomerular filtration (GO:0003094)3.47795386
32epithelial cell-cell adhesion (GO:0090136)3.44320116
33dermatan sulfate biosynthetic process (GO:0030208)3.43261857
34extracellular matrix assembly (GO:0085029)3.40962173
35tooth mineralization (GO:0034505)3.40043269
36adhesion of symbiont to host cell (GO:0044650)3.38655484
37virion attachment to host cell (GO:0019062)3.38655484
38cell migration involved in heart development (GO:0060973)3.36804717
39cell migration involved in sprouting angiogenesis (GO:0002042)3.35109046
40collagen metabolic process (GO:0032963)3.34832405
41apoptotic cell clearance (GO:0043277)3.34502472
42blood vessel maturation (GO:0001955)3.29646318
43insulin-like growth factor receptor signaling pathway (GO:0048009)3.28547151
44endothelial cell morphogenesis (GO:0001886)3.27409603
45stress fiber assembly (GO:0043149)3.26582904
46adhesion of symbiont to host (GO:0044406)3.25322409
47retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24302485
48polarized epithelial cell differentiation (GO:0030859)3.23853310
49negative regulation of chondrocyte differentiation (GO:0032331)3.23574390
50lymphangiogenesis (GO:0001946)3.22615428
51cochlea morphogenesis (GO:0090103)3.22044863
52collagen catabolic process (GO:0030574)3.21601153
53cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.18088897
54positive regulation of epithelial to mesenchymal transition (GO:0010718)3.17810049
55multicellular organismal macromolecule metabolic process (GO:0044259)3.17323557
56protein localization to endosome (GO:0036010)3.16301959
57adherens junction assembly (GO:0034333)3.14797030
58heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.13116297
59positive regulation of blood vessel endothelial cell migration (GO:0043536)3.10655893
60craniofacial suture morphogenesis (GO:0097094)3.10612256
61cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.10356841
62regulation of early endosome to late endosome transport (GO:2000641)3.09752137
63barbed-end actin filament capping (GO:0051016)3.09358042
64protein maturation by protein folding (GO:0022417)3.07951832
65dermatan sulfate metabolic process (GO:0030205)3.07144129
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06900851
67outer ear morphogenesis (GO:0042473)3.05519490
68metanephric mesenchyme development (GO:0072075)3.04407689
69cell-substrate junction assembly (GO:0007044)3.04048577
70cardiac myofibril assembly (GO:0055003)3.03752093
71Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.01269487
72substrate adhesion-dependent cell spreading (GO:0034446)2.99907555
73cell proliferation involved in metanephros development (GO:0072203)2.99216072
74multicellular organismal metabolic process (GO:0044236)2.98794194
75substrate-dependent cell migration (GO:0006929)2.98410673
76extracellular matrix disassembly (GO:0022617)2.98070872
77protein localization to cell surface (GO:0034394)2.97542226
78multicellular organismal catabolic process (GO:0044243)2.96892372
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96138570
80hemidesmosome assembly (GO:0031581)2.95223061
81blood vessel endothelial cell migration (GO:0043534)2.94852618
82fibril organization (GO:0097435)2.94532315
83wound healing, spreading of cells (GO:0044319)2.91990305
84kidney mesenchyme development (GO:0072074)2.91792699
85negative regulation of catenin import into nucleus (GO:0035414)2.90455245
86negative regulation of smooth muscle cell migration (GO:0014912)2.90061729
87positive regulation of osteoblast proliferation (GO:0033690)2.89587463
88atrioventricular valve morphogenesis (GO:0003181)2.88676643
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86324156
90UV protection (GO:0009650)2.86267136
91regulation of hippo signaling (GO:0035330)2.86238310
92branching involved in salivary gland morphogenesis (GO:0060445)2.85669606
93mesodermal cell differentiation (GO:0048333)2.84533615
94regulation of establishment of planar polarity (GO:0090175)2.83560386
95muscle cell migration (GO:0014812)2.83043571
96fibroblast migration (GO:0010761)2.79143902
97convergent extension (GO:0060026)2.78687139
98peptidyl-proline hydroxylation (GO:0019511)2.78317272
99regulation of SMAD protein import into nucleus (GO:0060390)2.78254836
100trabecula formation (GO:0060343)2.77741829
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77041435
102negative regulation of cartilage development (GO:0061037)2.76608948
103cellular response to vitamin (GO:0071295)2.75900593
104regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75829363
105protein hydroxylation (GO:0018126)2.75346438
106atrial septum morphogenesis (GO:0060413)2.74762033
107regulation of plasminogen activation (GO:0010755)2.73039761
108venous blood vessel morphogenesis (GO:0048845)2.72974972
109regulation of heart morphogenesis (GO:2000826)2.70724907
110glomerular visceral epithelial cell development (GO:0072015)2.70103620
111extracellular structure organization (GO:0043062)2.69327411
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.68732689
113hyaluronan catabolic process (GO:0030214)2.66865182
114cell-substrate adherens junction assembly (GO:0007045)2.66601463
115focal adhesion assembly (GO:0048041)2.66601463
116cellular response to interferon-alpha (GO:0035457)2.66135028
117negative regulation of embryonic development (GO:0045992)2.65875213
118positive regulation of cartilage development (GO:0061036)2.65785345
119heart trabecula formation (GO:0060347)2.64285273
120positive regulation of fatty acid oxidation (GO:0046321)2.63471461
121regulation of cartilage development (GO:0061035)2.62662624
122positive regulation of glycogen biosynthetic process (GO:0045725)2.61240459
123chondroitin sulfate biosynthetic process (GO:0030206)2.60190967
124actin filament depolymerization (GO:0030042)2.59305246
125chondrocyte development (GO:0002063)2.58420849
126dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57318991
127embryonic cranial skeleton morphogenesis (GO:0048701)2.57159908
128regulation of integrin-mediated signaling pathway (GO:2001044)2.54704242
129establishment of apical/basal cell polarity (GO:0035089)2.53926507
130positive regulation of mesenchymal cell proliferation (GO:0002053)2.53768924
131lymph vessel development (GO:0001945)2.53324488
132regulation of chondrocyte differentiation (GO:0032330)2.52844786
133cortical actin cytoskeleton organization (GO:0030866)2.52523055
134extracellular fibril organization (GO:0043206)2.51025757
135mesenchyme development (GO:0060485)2.50006469
136mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.46740900
137extracellular matrix organization (GO:0030198)2.45397216
138cell proliferation involved in kidney development (GO:0072111)2.45234693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.32005054
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.04937822
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.91406323
4CLOCK_20551151_ChIP-Seq_293T_Human3.63358186
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.53565750
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20524423
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.04358745
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.99533128
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.74639461
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71643539
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.50122565
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.37882677
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.37461435
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.33816855
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31704833
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.25074821
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.21832505
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.21576120
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.13331443
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.07356371
21BRD4_25478319_ChIP-Seq_HGPS_Human1.94056468
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.93540492
23CJUN_26792858_Chip-Seq_BT549_Human1.90079955
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79248597
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75569979
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75288873
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74368637
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.74260131
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.69749659
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.67744029
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.67744029
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66606530
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65161916
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65032776
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64975415
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.63165094
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62510696
38ATF3_27146783_Chip-Seq_COLON_Human1.62031751
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57959812
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56498266
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55616427
42RACK7_27058665_Chip-Seq_MCF-7_Human1.54029430
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53593939
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53593939
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52050063
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.49963763
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49556863
48ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48840412
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48615112
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.48552745
51TP53_22127205_ChIP-Seq_IMR90_Human1.48252635
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48038224
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48004788
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47748875
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47317737
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45790017
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45293688
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42340261
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41967461
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.41349851
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40393978
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39363471
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35609637
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.35481672
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35064127
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33239235
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.32243210
68TP53_23651856_ChIP-Seq_MEFs_Mouse1.30796121
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30228490
70KDM2B_26808549_Chip-Seq_DND41_Human1.30006210
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28844499
72VDR_21846776_ChIP-Seq_THP-1_Human1.28625909
73LXR_22292898_ChIP-Seq_THP-1_Human1.27755240
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25831087
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.25753193
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24621486
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24531764
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.23374949
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23320017
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22914765
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22538837
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22453372
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22153148
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21506814
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20843369
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18652177
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18652177
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18112836
89KDM2B_26808549_Chip-Seq_K562_Human1.17301277
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16903928
91SA1_22415368_ChIP-Seq_MEFs_Mouse1.16257542
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14974271
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13922497
94ZNF263_19887448_ChIP-Seq_K562_Human1.13817598
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.13456745
96AR_21909140_ChIP-Seq_LNCAP_Human1.12994272
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11254560
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10328663
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07243261
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.07211398
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.07067612
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06563094
103SOX2_20726797_ChIP-Seq_SW620_Human1.05313995
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.04641625
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02673876
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02031223
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00640680
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00639323
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00599585
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99989259
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99730370
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99415830
113HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98238205
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98178554
115FOXM1_23109430_ChIP-Seq_U2OS_Human0.98075725
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97899496
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97283719
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97173533
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.97024907
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96732314
121EED_16625203_ChIP-ChIP_MESCs_Mouse0.96378836
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96121721
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95335025
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93995271
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92044922
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92044922
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89975113
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89429226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.38090232
2MP0005503_abnormal_tendon_morphology4.11724033
3MP0003705_abnormal_hypodermis_morpholog3.93979854
4MP0005275_abnormal_skin_tensile3.86064610
5MP0003279_aneurysm3.57203841
6MP0004272_abnormal_basement_membrane3.36570646
7MP0005623_abnormal_meninges_morphology3.15162389
8MP0001958_emphysema2.75420997
9MP0010368_abnormal_lymphatic_system2.53650761
10MP0009384_cardiac_valve_regurgitation2.40213933
11MP0010030_abnormal_orbit_morphology2.38358734
12MP0006054_spinal_hemorrhage2.33973252
13MP0003566_abnormal_cell_adhesion2.20247445
14MP0001542_abnormal_bone_strength1.88583079
15MP0000733_abnormal_muscle_development1.87927301
16MP0005508_abnormal_skeleton_morphology1.83411586
17MP0003385_abnormal_body_wall1.81813020
18MP0003091_abnormal_cell_migration1.81590310
19MP0004084_abnormal_cardiac_muscle1.78073208
20MP0003950_abnormal_plasma_membrane1.77205929
21MP0005023_abnormal_wound_healing1.76619729
22MP0005171_absent_coat_pigmentation1.76562681
23MP0010352_gastrointestinal_tract_polyps1.75069860
24MP0009250_abnormal_appendicular_skeleto1.72566251
25MP0001879_abnormal_lymphatic_vessel1.68936575
26MP0004858_abnormal_nervous_system1.65454603
27MP0005257_abnormal_intraocular_pressure1.63868681
28MP0000751_myopathy1.62737851
29MP0003942_abnormal_urinary_system1.62097045
30MP0009053_abnormal_anal_canal1.57628280
31MP0000767_abnormal_smooth_muscle1.53208179
32MP0001849_ear_inflammation1.50368666
33MP0000750_abnormal_muscle_regeneration1.50310786
34MP0002108_abnormal_muscle_morphology1.49287775
35MP0002295_abnormal_pulmonary_circulatio1.46918090
36MP0000534_abnormal_ureter_morphology1.45483409
37MP0000013_abnormal_adipose_tissue1.42707429
38MP0006138_congestive_heart_failure1.39209163
39MP0002060_abnormal_skin_morphology1.33830426
40MP0003115_abnormal_respiratory_system1.33468406
41MP0000428_abnormal_craniofacial_morphol1.27118033
42MP0004087_abnormal_muscle_fiber1.26569578
43MP0002896_abnormal_bone_mineralization1.22874336
44MP0001299_abnormal_eye_distance/1.20652686
45MP0008775_abnormal_heart_ventricle1.20495372
46MP0000537_abnormal_urethra_morphology1.18934309
47MP0010630_abnormal_cardiac_muscle1.18189194
48MP0002932_abnormal_joint_morphology1.17441534
49MP0002128_abnormal_blood_circulation1.16815589
50MP0000003_abnormal_adipose_tissue1.15963835
51MP0000762_abnormal_tongue_morphology1.15534467
52MP0003941_abnormal_skin_development1.13284134
53MP0002089_abnormal_postnatal_growth/wei1.13107681
54MP0004233_abnormal_muscle_weight1.13015427
55MP0002282_abnormal_trachea_morphology1.10680100
56MP0000163_abnormal_cartilage_morphology1.10383141
57MP0003283_abnormal_digestive_organ1.10319405
58MP0005670_abnormal_white_adipose1.09273606
59MP0005197_abnormal_uvea_morphology1.08697522
60MP0005409_darkened_coat_color1.08037016
61MP0000749_muscle_degeneration1.07757871
62MP0005330_cardiomyopathy1.06738886
63MP0002249_abnormal_larynx_morphology1.05119815
64MP0001243_abnormal_dermal_layer1.03951530
65MP0003935_abnormal_craniofacial_develop1.03922219
66MP0001614_abnormal_blood_vessel1.01590394
67MP0002925_abnormal_cardiovascular_devel1.01379466
68MP0005076_abnormal_cell_differentiation1.00663946
69MP0000759_abnormal_skeletal_muscle0.99920617
70MP0002115_abnormal_skeleton_extremities0.99179176
71MP0000049_abnormal_middle_ear0.98940199
72MP0001544_abnormal_cardiovascular_syste0.98832249
73MP0005385_cardiovascular_system_phenoty0.98832249
74MP0005375_adipose_tissue_phenotype0.98309461
75MP0002837_dystrophic_cardiac_calcinosis0.97586898
76MP0004036_abnormal_muscle_relaxation0.95248794
77MP0001661_extended_life_span0.94715112
78MP0002877_abnormal_melanocyte_morpholog0.94625017
79MP0003755_abnormal_palate_morphology0.94456800
80MP0002113_abnormal_skeleton_development0.91333805
81MP0005058_abnormal_lysosome_morphology0.90932952
82MP0005666_abnormal_adipose_tissue0.89807254
83MP0003122_maternal_imprinting0.89780456
84MP0009780_abnormal_chondrocyte_physiolo0.88892086
85MP0000266_abnormal_heart_morphology0.88549184
86MP0003828_pulmonary_edema0.88027951
87MP0003045_fibrosis0.86948848
88MP0002972_abnormal_cardiac_muscle0.84456876
89MP0004197_abnormal_fetal_growth/weight/0.84285689
90MP0000432_abnormal_head_morphology0.83564555
91MP0002168_other_aberrant_phenotype0.83356468
92MP0009840_abnormal_foam_cell0.82919138
93MP0003937_abnormal_limbs/digits/tail_de0.82535878
94MP0000462_abnormal_digestive_system0.82512872
95MP0005390_skeleton_phenotype0.81986124
96MP0001915_intracranial_hemorrhage0.81841565
97MP0004134_abnormal_chest_morphology0.79090828
98MP0005620_abnormal_muscle_contractility0.79075643
99MP0009278_abnormal_bone_marrow0.79052474
100MP0005595_abnormal_vascular_smooth0.78996220
101MP0004185_abnormal_adipocyte_glucose0.78943637
102MP0002111_abnormal_tail_morphology0.78750857
103MP0001348_abnormal_lacrimal_gland0.78325288
104MP0004808_abnormal_hematopoietic_stem0.78146187
105MP0001175_abnormal_lung_morphology0.78068084
106MP0002116_abnormal_craniofacial_bone0.77532974
107MP0005193_abnormal_anterior_eye0.77279805
108MP0003567_abnormal_fetal_cardiomyocyte0.77062768
109MP0002109_abnormal_limb_morphology0.76471397
110MP0005369_muscle_phenotype0.75081928
111MP0002933_joint_inflammation0.73818483
112MP0002269_muscular_atrophy0.73751665
113MP0002114_abnormal_axial_skeleton0.72834065
114MP0003448_altered_tumor_morphology0.72353182
115MP0000747_muscle_weakness0.72293240
116MP0002234_abnormal_pharynx_morphology0.72114375
117MP0002697_abnormal_eye_size0.68944679
118MP0000858_altered_metastatic_potential0.67297994
119MP0005621_abnormal_cell_physiology0.61867406
120MP0002092_abnormal_eye_morphology0.61021070
121MP0000467_abnormal_esophagus_morphology0.60839752
122MP0003453_abnormal_keratinocyte_physiol0.59761434
123MP0000678_abnormal_parathyroid_gland0.58724562
124MP0005165_increased_susceptibility_to0.57444024
125MP0005451_abnormal_body_composition0.54086327

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.73284587
2Premature rupture of membranes (HP:0001788)6.70544327
3Shallow orbits (HP:0000586)5.07531043
4Broad metatarsal (HP:0001783)4.99535621
5Ankle contracture (HP:0006466)4.78075175
6Aortic dissection (HP:0002647)4.37468930
7Cerebral aneurysm (HP:0004944)4.12754350
8Aortic aneurysm (HP:0004942)3.92020593
9Soft skin (HP:0000977)3.72566066
10Atrophic scars (HP:0001075)3.64597096
11Peritonitis (HP:0002586)3.60036288
12Increased connective tissue (HP:0009025)3.59671627
13Dilatation of the ascending aorta (HP:0005111)3.55443167
14Bladder diverticulum (HP:0000015)3.52658873
15Cervical subluxation (HP:0003308)3.44866120
16Fragile skin (HP:0001030)3.24528812
17Mitral valve prolapse (HP:0001634)3.20932607
18Abnormality of dentin (HP:0010299)3.20284236
19Spinal rigidity (HP:0003306)3.19664167
20Type 1 muscle fiber predominance (HP:0003803)3.11296379
21Wrist flexion contracture (HP:0001239)3.00371613
22Genu recurvatum (HP:0002816)2.90938170
23Blue sclerae (HP:0000592)2.90714765
24Neonatal short-limb short stature (HP:0008921)2.90538297
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88207951
26Short 4th metacarpal (HP:0010044)2.88207951
27Vertebral compression fractures (HP:0002953)2.81546498
28Wormian bones (HP:0002645)2.78910312
29Biconcave vertebral bodies (HP:0004586)2.76829355
30Aneurysm (HP:0002617)2.66900673
31Increased variability in muscle fiber diameter (HP:0003557)2.65247919
32Camptodactyly of toe (HP:0001836)2.62770992
33Mesomelia (HP:0003027)2.62385949
34Abnormality of the 4th metacarpal (HP:0010012)2.62355887
35Achilles tendon contracture (HP:0001771)2.60920438
36Thin bony cortex (HP:0002753)2.60184201
37Bowel diverticulosis (HP:0005222)2.55720391
38Follicular hyperkeratosis (HP:0007502)2.50172877
39Vascular tortuosity (HP:0004948)2.39606705
40Hyperextensible skin (HP:0000974)2.37594304
41Hyperacusis (HP:0010780)2.36916500
42Wide anterior fontanel (HP:0000260)2.36863820
43Deviation of the hallux (HP:0010051)2.36763145
44Abnormality of the acetabulum (HP:0003170)2.34340883
45Mildly elevated creatine phosphokinase (HP:0008180)2.34293998
46Muscle fiber splitting (HP:0003555)2.34035661
47Abnormality of skeletal muscle fiber size (HP:0012084)2.32408961
48Aortic regurgitation (HP:0001659)2.32036059
49Spondylolisthesis (HP:0003302)2.32030590
50Generalized amyotrophy (HP:0003700)2.30629817
51Radial bowing (HP:0002986)2.30492934
52Ulnar bowing (HP:0003031)2.29910345
53Lymphangioma (HP:0100764)2.27851040
54Abnormality of the Achilles tendon (HP:0005109)2.27447352
55Hallux valgus (HP:0001822)2.24750719
56Hypoventilation (HP:0002791)2.24664849
57Coronal craniosynostosis (HP:0004440)2.24510489
58Scapular winging (HP:0003691)2.22242761
59Short nail (HP:0001799)2.21265726
60Elbow flexion contracture (HP:0002987)2.20670709
61Joint laxity (HP:0001388)2.20640450
62Bowing of the arm (HP:0006488)2.19793487
63Bowed forearm bones (HP:0003956)2.19793487
64Overgrowth (HP:0001548)2.17575278
65Buphthalmos (HP:0000557)2.13619588
66Syringomyelia (HP:0003396)2.11838782
67Spinal cord lesions (HP:0100561)2.11838782
68Arterial tortuosity (HP:0005116)2.11452530
69Distal lower limb amyotrophy (HP:0008944)2.10498519
70Difficulty climbing stairs (HP:0003551)2.09800566
71Increased density of long bones (HP:0006392)2.09535373
72Ectopia lentis (HP:0001083)2.08442973
73Abnormal delivery (HP:0001787)2.08101436
74Joint stiffness (HP:0001387)2.07821150
75Long toe (HP:0010511)2.06745046
76Mitral regurgitation (HP:0001653)2.06463692
77Infantile muscular hypotonia (HP:0008947)2.03943153
78Knee flexion contracture (HP:0006380)2.03685689
79Mesangial abnormality (HP:0001966)2.01225866
80Premature skin wrinkling (HP:0100678)2.00378755
81Joint contractures involving the joints of the feet (HP:0100492)1.98861275
82Flexion contracture of toe (HP:0005830)1.98861275
83Distal upper limb amyotrophy (HP:0007149)1.97326574
84Upper limb amyotrophy (HP:0009129)1.97326574
85Bell-shaped thorax (HP:0001591)1.97134447
86Abnormality of the peritoneum (HP:0002585)1.96594675
87Natal tooth (HP:0000695)1.96368897
88Broad long bones (HP:0005622)1.95010195
89Delayed cranial suture closure (HP:0000270)1.94496238
90Mitral stenosis (HP:0001718)1.94391002
91Protruding ear (HP:0000411)1.93707502
92Renal duplication (HP:0000075)1.92289063
93Turricephaly (HP:0000262)1.92012116
94Venous abnormality (HP:0002624)1.90011602
95Broad face (HP:0000283)1.88301619
96Slender build (HP:0001533)1.88142749
97Breech presentation (HP:0001623)1.87457851
98Osteolytic defects of the hand bones (HP:0009699)1.85027512
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.85027512
100Right ventricular cardiomyopathy (HP:0011663)1.84860780
101Hyporeflexia of lower limbs (HP:0002600)1.83340851
102Osteopenia (HP:0000938)1.83085864
103Round ear (HP:0100830)1.82774469
104Inguinal hernia (HP:0000023)1.82761614
105Thin ribs (HP:0000883)1.82695757
106Coxa vara (HP:0002812)1.82594243
107Tibial bowing (HP:0002982)1.81278115
108Asymmetry of the thorax (HP:0001555)1.80400275
109Selective tooth agenesis (HP:0001592)1.80269192
110Hip contracture (HP:0003273)1.80038062
111Disproportionate tall stature (HP:0001519)1.80037542
112Venous insufficiency (HP:0005293)1.80018667
113Abnormality of the umbilical cord (HP:0010881)1.79739363
114Enlarged penis (HP:0000040)1.79739263
115Aortic valve stenosis (HP:0001650)1.78818455
116Congenital glaucoma (HP:0001087)1.78454609
117Broad toe (HP:0001837)1.77694947
118Mild short stature (HP:0003502)1.77518389
119Nonimmune hydrops fetalis (HP:0001790)1.77252191
120Reduced subcutaneous adipose tissue (HP:0003758)1.76592295
121Tarsal synostosis (HP:0008368)1.76134457
122Stridor (HP:0010307)1.75282868
123Dislocated radial head (HP:0003083)1.75069763
124Limb-girdle muscle weakness (HP:0003325)1.74595067
125Arachnodactyly (HP:0001166)1.73188573
126Rectal prolapse (HP:0002035)1.72793177
127Lipoatrophy (HP:0100578)1.72289776
128Distal lower limb muscle weakness (HP:0009053)1.71992060
129Broad ribs (HP:0000885)1.71671137
130Abnormality of the calcaneus (HP:0008364)1.71113356
131Abnormal ossification of hand bones (HP:0005921)1.70714924
132Flat cornea (HP:0007720)1.70507496
133Abnormality of the distal phalanges of the toes (HP:0010182)1.70070703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.86909906
2TTN4.40981072
3DDR23.46125614
4LATS13.41597821
5PDGFRA3.18631200
6PKN23.14746964
7LATS23.05170101
8SMG12.72823727
9IRAK32.47914840
10EPHB22.28885048
11SIK12.21859448
12ERN12.12228016
13TIE12.03871561
14RIPK12.03170758
15PAK21.91465022
16PTK61.84635067
17MYLK1.84029476
18DMPK1.84021612
19TGFBR21.81278737
20EEF2K1.74683145
21LRRK21.73081578
22BMX1.72454599
23PAK41.63128360
24PTK21.62594932
25TGFBR11.60426324
26ILK1.58383059
27FER1.44027889
28NME21.43079329
29KDR1.35151791
30STK38L1.34870238
31PAK31.32352957
32ERBB41.31431494
33PTK2B1.29418350
34MET1.26778929
35RPS6KA41.26106577
36MTOR1.19590287
37FGFR11.18770428
38STK31.17175299
39TAOK21.16057330
40ARAF1.14276430
41CAMK1D1.13719545
42PRPF4B1.12049847
43TRPM71.07761855
44MAP3K101.07635659
45TESK11.06256627
46ROCK11.06196497
47PRKD31.04904589
48PIK3CA1.03740438
49PDGFRB1.00597004
50LIMK11.00538810
51LMTK21.00078729
52CDK80.98809009
53RPS6KA20.94437203
54MAP3K60.91530570
55EPHA30.90206460
56BUB10.87723697
57MOS0.85987919
58NEK90.84168940
59MAP2K10.84160716
60VRK20.82873018
61PRKD10.81572339
62PAK60.80245279
63CAMK1G0.75710524
64CDK60.74455850
65PIM20.71687570
66ROCK20.71622328
67PRKD20.70069263
68MELK0.69250617
69MAP2K30.68573508
70BRAF0.68180023
71PRKG20.67077238
72NEK20.66905679
73EPHB10.64893123
74NEK10.63308675
75GSK3A0.62911671
76EPHA20.59654814
77AKT30.59567327
78CDC42BPA0.59282063
79BRSK10.58965114
80PDK30.58218491
81PDK40.58218491
82DAPK30.57659478
83PDPK10.56016068
84MAP3K70.55701312
85PAK10.54829043
86RPS6KL10.54601640
87RPS6KC10.54601640
88RET0.53392948
89MAPK110.53337262
90MAP3K80.53075087
91STK100.52760092
92PRKCH0.52445524
93KSR20.49770337
94AURKA0.49111125
95ICK0.48525318
96FLT30.46934180
97MST1R0.46115773
98MAPK70.45537461
99CDK150.45523051
100INSR0.45089556
101CDK11A0.45059792
102TESK20.44722963
103IRAK20.44076598
104FGFR20.43900302
105WNK10.42974782
106CHEK20.41026953
107STK380.40984344
108AKT20.40510244
109GRK50.40486907
110CDK180.40299523
111RPS6KB20.39984284
112CDK120.39464392
113SRC0.39452977
114CDK90.39322180
115TAOK10.39188771
116HIPK20.38409505
117CDK70.37537085
118STK40.37114292
119DYRK1B0.36997345
120RPS6KA60.35767368
121MAPKAPK30.34939462
122CAMK2G0.34523459
123CLK10.34019125
124ABL20.33605789
125TYRO30.32629512
126ERBB20.32532754
127CAMKK10.30614493
128FGFR40.28841220
129MAP3K30.28776446
130PIK3CG0.28430679
131WNK40.28156901
132MAPK10.28027934
133ADRBK10.26021951
134PDK20.24811959
135PRKAA20.24752308
136MAPKAPK20.23410175
137NTRK10.23145476
138CDK140.22853381

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.97637822
2Focal adhesion_Homo sapiens_hsa045103.24402925
3Proteoglycans in cancer_Homo sapiens_hsa052052.50935177
4Dilated cardiomyopathy_Homo sapiens_hsa054142.42255946
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.41090769
6Adherens junction_Homo sapiens_hsa045202.35665560
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.29370213
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27164089
9Bladder cancer_Homo sapiens_hsa052192.22151438
10Small cell lung cancer_Homo sapiens_hsa052222.12390222
11Hippo signaling pathway_Homo sapiens_hsa043902.09040639
12Protein digestion and absorption_Homo sapiens_hsa049742.03416775
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00769320
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.99229006
15Basal cell carcinoma_Homo sapiens_hsa052171.98189971
16TGF-beta signaling pathway_Homo sapiens_hsa043501.96931355
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90943839
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83952911
19Amoebiasis_Homo sapiens_hsa051461.79882951
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78602434
21MicroRNAs in cancer_Homo sapiens_hsa052061.78392688
22Sulfur relay system_Homo sapiens_hsa041221.68323427
23Chronic myeloid leukemia_Homo sapiens_hsa052201.60615128
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59476104
25Hedgehog signaling pathway_Homo sapiens_hsa043401.56062129
26Prion diseases_Homo sapiens_hsa050201.44833471
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44030664
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39787703
29Viral myocarditis_Homo sapiens_hsa054161.38520809
30Melanoma_Homo sapiens_hsa052181.35292204
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35157449
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.32769442
33Tight junction_Homo sapiens_hsa045301.31933244
34Other glycan degradation_Homo sapiens_hsa005111.31760881
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31722459
36Pathways in cancer_Homo sapiens_hsa052001.20421110
37N-Glycan biosynthesis_Homo sapiens_hsa005101.18319410
38Rap1 signaling pathway_Homo sapiens_hsa040151.18237733
39Galactose metabolism_Homo sapiens_hsa000521.14234745
40p53 signaling pathway_Homo sapiens_hsa041151.14095567
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.11569411
42Platelet activation_Homo sapiens_hsa046111.11199682
43Prostate cancer_Homo sapiens_hsa052151.10016847
44Pentose phosphate pathway_Homo sapiens_hsa000301.08289521
45Shigellosis_Homo sapiens_hsa051311.06815801
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05364893
47Glioma_Homo sapiens_hsa052141.05318580
48HIF-1 signaling pathway_Homo sapiens_hsa040661.00441775
49Malaria_Homo sapiens_hsa051440.99998040
50Fatty acid metabolism_Homo sapiens_hsa012120.98767782
51Pancreatic cancer_Homo sapiens_hsa052120.97661637
52Fatty acid degradation_Homo sapiens_hsa000710.94560970
53Notch signaling pathway_Homo sapiens_hsa043300.93957781
54AMPK signaling pathway_Homo sapiens_hsa041520.93253218
55HTLV-I infection_Homo sapiens_hsa051660.92965463
56PPAR signaling pathway_Homo sapiens_hsa033200.92963574
57Lysine degradation_Homo sapiens_hsa003100.92508265
58Axon guidance_Homo sapiens_hsa043600.90464605
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89812057
60Vibrio cholerae infection_Homo sapiens_hsa051100.89746934
61Insulin resistance_Homo sapiens_hsa049310.88329084
62Wnt signaling pathway_Homo sapiens_hsa043100.87966854
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85836333
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85222962
65Melanogenesis_Homo sapiens_hsa049160.83334076
66Vitamin B6 metabolism_Homo sapiens_hsa007500.80804842
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80268053
68Fructose and mannose metabolism_Homo sapiens_hsa000510.80071581
69mTOR signaling pathway_Homo sapiens_hsa041500.79725499
70Renal cell carcinoma_Homo sapiens_hsa052110.78447984
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78081879
72Endometrial cancer_Homo sapiens_hsa052130.76334910
73Gap junction_Homo sapiens_hsa045400.75250557
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.75236763
75Carbon metabolism_Homo sapiens_hsa012000.72462437
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72117801
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71281401
78Thyroid cancer_Homo sapiens_hsa052160.71092885
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69749730
80Colorectal cancer_Homo sapiens_hsa052100.69186866
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.68655696
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.68261900
83Insulin signaling pathway_Homo sapiens_hsa049100.68109591
84Ovarian steroidogenesis_Homo sapiens_hsa049130.67120753
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66145042
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65797817
87Estrogen signaling pathway_Homo sapiens_hsa049150.65629430
88Toxoplasmosis_Homo sapiens_hsa051450.64864771
89VEGF signaling pathway_Homo sapiens_hsa043700.63012537
90ErbB signaling pathway_Homo sapiens_hsa040120.58846636
91GnRH signaling pathway_Homo sapiens_hsa049120.58031086
92Viral carcinogenesis_Homo sapiens_hsa052030.57174190
93Cell cycle_Homo sapiens_hsa041100.56465705
94Glucagon signaling pathway_Homo sapiens_hsa049220.56378998
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.56222317
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55620400
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54924570
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54394171
99Propanoate metabolism_Homo sapiens_hsa006400.54391279
100Thyroid hormone synthesis_Homo sapiens_hsa049180.53272729
101Caffeine metabolism_Homo sapiens_hsa002320.52458640
102Biosynthesis of amino acids_Homo sapiens_hsa012300.51527954
103FoxO signaling pathway_Homo sapiens_hsa040680.51150920
104Endocytosis_Homo sapiens_hsa041440.49892375
105TNF signaling pathway_Homo sapiens_hsa046680.48376866
106Pyruvate metabolism_Homo sapiens_hsa006200.47820518
107Ras signaling pathway_Homo sapiens_hsa040140.47639752
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46709014
109Lysosome_Homo sapiens_hsa041420.45661652
110Non-small cell lung cancer_Homo sapiens_hsa052230.44711172
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.44511920
112MAPK signaling pathway_Homo sapiens_hsa040100.44500810
113Hepatitis B_Homo sapiens_hsa051610.41285209
114Acute myeloid leukemia_Homo sapiens_hsa052210.40963301
115Apoptosis_Homo sapiens_hsa042100.40837633
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40251931
117Salmonella infection_Homo sapiens_hsa051320.39646573
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.39016615
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38581132
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38512151

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