SYDE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)4.16549526
2bundle of His cell to Purkinje myocyte communication (GO:0086069)4.09899422
3nuclear pore organization (GO:0006999)4.03976026
4paraxial mesoderm development (GO:0048339)4.00351410
5daunorubicin metabolic process (GO:0044597)3.98722524
6polyketide metabolic process (GO:0030638)3.98722524
7doxorubicin metabolic process (GO:0044598)3.98722524
8nuclear pore complex assembly (GO:0051292)3.95969261
9cardiac myofibril assembly (GO:0055003)3.81888264
10positive regulation of catenin import into nucleus (GO:0035413)3.69444776
11sarcomere organization (GO:0045214)3.66234796
12regulation of gene silencing by miRNA (GO:0060964)3.59113819
13regulation of gene silencing by RNA (GO:0060966)3.59113819
14regulation of posttranscriptional gene silencing (GO:0060147)3.59113819
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54852093
16carnitine shuttle (GO:0006853)3.44490879
17protein prenylation (GO:0018342)3.34893776
18prenylation (GO:0097354)3.34893776
19protein K11-linked deubiquitination (GO:0035871)3.29197221
20regulation of helicase activity (GO:0051095)3.28319139
21synapsis (GO:0007129)3.26815881
22regulation of centrosome duplication (GO:0010824)3.25175868
23fatty acid transmembrane transport (GO:1902001)3.22376466
24cardiac muscle cell development (GO:0055013)3.20399563
25fatty acid beta-oxidation (GO:0006635)3.19203670
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.17944998
27regulation of cardioblast differentiation (GO:0051890)3.10596233
28aminoglycoside antibiotic metabolic process (GO:0030647)3.10591044
29replication fork processing (GO:0031297)3.04536436
30reciprocal DNA recombination (GO:0035825)3.04171282
31reciprocal meiotic recombination (GO:0007131)3.04171282
32regulation of centrosome cycle (GO:0046605)3.03167591
33gap junction assembly (GO:0016264)3.02750101
34lysine metabolic process (GO:0006553)3.00268305
35lysine catabolic process (GO:0006554)3.00268305
36cardiac cell development (GO:0055006)3.00150678
37regulation of spindle organization (GO:0090224)2.99191482
38dorsal/ventral axis specification (GO:0009950)2.96116828
39tricarboxylic acid cycle (GO:0006099)2.95887734
40myofibril assembly (GO:0030239)2.95474796
41negative regulation of translation, ncRNA-mediated (GO:0040033)2.93996402
42regulation of translation, ncRNA-mediated (GO:0045974)2.93996402
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93996402
44positive regulation of SMAD protein import into nucleus (GO:0060391)2.92625840
45ventricular cardiac muscle cell action potential (GO:0086005)2.91912157
462-oxoglutarate metabolic process (GO:0006103)2.91234696
47IMP biosynthetic process (GO:0006188)2.89262917
48ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.88403991
49regulation of mesoderm development (GO:2000380)2.86891251
50DNA replication checkpoint (GO:0000076)2.83220873
51regulation of DNA endoreduplication (GO:0032875)2.79004687
52somatic hypermutation of immunoglobulin genes (GO:0016446)2.78979868
53somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78979868
54regulation of RNA export from nucleus (GO:0046831)2.76658894
55homocysteine metabolic process (GO:0050667)2.76051362
56negative regulation of fatty acid biosynthetic process (GO:0045717)2.75736436
57regulation of mitotic spindle organization (GO:0060236)2.75365563
58nucleobase biosynthetic process (GO:0046112)2.75364907
59cardiac muscle tissue morphogenesis (GO:0055008)2.75352411
60acetyl-CoA metabolic process (GO:0006084)2.74474334
61adult heart development (GO:0007512)2.71878672
62fatty acid oxidation (GO:0019395)2.70145140
63DNA unwinding involved in DNA replication (GO:0006268)2.68653404
64regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67150869
65glycine metabolic process (GO:0006544)2.67136569
66nodal signaling pathway (GO:0038092)2.66310232
67carnitine transmembrane transport (GO:1902603)2.65731704
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.65415347
69lipid oxidation (GO:0034440)2.65157363
70regulation of mitotic spindle checkpoint (GO:1903504)2.64824653
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64824653
72double-strand break repair via homologous recombination (GO:0000724)2.64562840
73mitotic metaphase plate congression (GO:0007080)2.64171611
74cornea development in camera-type eye (GO:0061303)2.63676154
75short-chain fatty acid metabolic process (GO:0046459)2.62971078
76recombinational repair (GO:0000725)2.62462750
77negative regulation of striated muscle cell apoptotic process (GO:0010664)2.62371796
78histone H2A monoubiquitination (GO:0035518)2.62314812
79biotin metabolic process (GO:0006768)2.62278800
80kidney morphogenesis (GO:0060993)2.60922302
81tricarboxylic acid metabolic process (GO:0072350)2.60601182
82pore complex assembly (GO:0046931)2.60179017
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59593420
84carnitine transport (GO:0015879)2.59118155
85amino-acid betaine transport (GO:0015838)2.59118155
86response to pheromone (GO:0019236)2.58210751
87notochord development (GO:0030903)2.57911454
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.57826781
89folic acid-containing compound biosynthetic process (GO:0009396)2.56581281
90protein K6-linked ubiquitination (GO:0085020)2.55818607
91fatty acid catabolic process (GO:0009062)2.55252673
92heart trabecula formation (GO:0060347)2.54097167
93regulation of hippo signaling (GO:0035330)2.52170835
94meiotic chromosome segregation (GO:0045132)2.51199136
95regulation of tight junction assembly (GO:2000810)2.50811506
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50545670
97embryonic foregut morphogenesis (GO:0048617)2.49732520
98valine metabolic process (GO:0006573)2.49727841
99IMP metabolic process (GO:0046040)2.49462654
100purine nucleobase biosynthetic process (GO:0009113)2.49424699
101muscle tissue morphogenesis (GO:0060415)2.48984243
102mitotic nuclear envelope disassembly (GO:0007077)2.48916331
103regulation of SMAD protein import into nucleus (GO:0060390)2.48843488
104serine family amino acid catabolic process (GO:0009071)2.48405682
105fatty acid homeostasis (GO:0055089)2.48282872
106regulation of histone H3-K9 methylation (GO:0051570)2.46805337
107L-fucose catabolic process (GO:0042355)2.46184789
108fucose catabolic process (GO:0019317)2.46184789
109L-fucose metabolic process (GO:0042354)2.46184789
110metaphase plate congression (GO:0051310)2.45758922
111glyoxylate metabolic process (GO:0046487)2.45026074
112positive regulation of fatty acid oxidation (GO:0046321)2.43940096
113mitotic chromosome condensation (GO:0007076)2.43214870
114protein localization to kinetochore (GO:0034501)2.43163321
115ventricular cardiac muscle cell development (GO:0055015)2.42725683
116DNA double-strand break processing (GO:0000729)2.41946172
117male meiosis (GO:0007140)2.41208298
118cardiac muscle contraction (GO:0060048)2.41201924
119epithelial cell-cell adhesion (GO:0090136)2.41156425
120positive regulation of DNA-templated transcription, initiation (GO:2000144)2.40240199
121regulation of translational fidelity (GO:0006450)2.40079101
122branched-chain amino acid catabolic process (GO:0009083)2.39920310
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.39289711
124actomyosin structure organization (GO:0031032)2.39021157
125mitotic sister chromatid cohesion (GO:0007064)2.38067378
126limb bud formation (GO:0060174)2.37842189
127hippo signaling (GO:0035329)2.37692809
128embryonic axis specification (GO:0000578)2.36839980
129DNA replication-dependent nucleosome organization (GO:0034723)2.36721947
130DNA replication-dependent nucleosome assembly (GO:0006335)2.36721947
131photoreceptor cell maintenance (GO:0045494)2.36111843
132oxygen transport (GO:0015671)2.36011743
133telomere maintenance via telomerase (GO:0007004)2.34326753
134male meiosis I (GO:0007141)2.33250551
135somite rostral/caudal axis specification (GO:0032525)2.32875852
136muscle filament sliding (GO:0030049)2.32500036
137actin-myosin filament sliding (GO:0033275)2.32500036
138embryonic pattern specification (GO:0009880)2.32196575
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.31493134
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.31486349
141isotype switching (GO:0045190)2.31486349
142somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.31486349
143anterior/posterior axis specification, embryo (GO:0008595)2.31224961
144atrial cardiac muscle cell action potential (GO:0086014)2.31094107
145piRNA metabolic process (GO:0034587)2.29497652
146positive regulation of chromosome segregation (GO:0051984)2.29359844
147branched-chain amino acid metabolic process (GO:0009081)2.29028478
148keratinocyte development (GO:0003334)2.28868484
149DNA strand renaturation (GO:0000733)2.28606255
150regulation of fatty acid oxidation (GO:0046320)2.28550700
151positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.28300165
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28209884
153nephron tubule morphogenesis (GO:0072078)2.27248285
154nephron epithelium morphogenesis (GO:0072088)2.27248285
155somatic diversification of immunoglobulins (GO:0016445)2.27140690
156ribosome assembly (GO:0042255)2.26787662
157centriole replication (GO:0007099)2.26286951
158regulation of acyl-CoA biosynthetic process (GO:0050812)2.26085919
159cellular ketone body metabolic process (GO:0046950)2.25552864
160prostate gland growth (GO:0060736)2.25384042
161chromatin remodeling at centromere (GO:0031055)2.24871106
162positive regulation of embryonic development (GO:0040019)2.23813459
163regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.22947609
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.22634943
165respiratory chain complex IV assembly (GO:0008535)2.22252007
166resolution of meiotic recombination intermediates (GO:0000712)2.22007849
167reflex (GO:0060004)2.21530846
168water-soluble vitamin biosynthetic process (GO:0042364)2.20732221
169negative regulation of hormone biosynthetic process (GO:0032353)2.20585663
170intestinal epithelial cell development (GO:0060576)2.19968298
171pericardium development (GO:0060039)2.19858126
172magnesium ion transport (GO:0015693)2.14787408
173female gonad development (GO:0008585)2.14601436
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.13679505
175establishment of monopolar cell polarity (GO:0061162)2.13679505
176otic vesicle formation (GO:0030916)2.13463583
177left/right axis specification (GO:0070986)2.11727217
178somite development (GO:0061053)2.09641998
179epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.09412430
180ketone body metabolic process (GO:1902224)2.08976028
181somatic recombination of immunoglobulin gene segments (GO:0016447)2.08130620
182DNA methylation involved in gamete generation (GO:0043046)2.07840115
183pseudouridine synthesis (GO:0001522)2.07757846
184CENP-A containing nucleosome assembly (GO:0034080)2.07728290
185artery development (GO:0060840)2.07299284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87202591
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74492801
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.54366985
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.48473893
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.16870266
6AR_21909140_ChIP-Seq_LNCAP_Human3.04170068
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.03768769
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85614053
9ZNF274_21170338_ChIP-Seq_K562_Hela2.74773454
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68042745
11FUS_26573619_Chip-Seq_HEK293_Human2.61271913
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59406797
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.55884544
14VDR_22108803_ChIP-Seq_LS180_Human2.50717115
15EWS_26573619_Chip-Seq_HEK293_Human2.49029664
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45427396
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41391600
18CLOCK_20551151_ChIP-Seq_293T_Human2.40518483
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37480290
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.29947411
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26106786
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18727147
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13892733
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10323890
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.07061902
26GBX2_23144817_ChIP-Seq_PC3_Human2.06137025
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04352766
28P300_19829295_ChIP-Seq_ESCs_Human2.03847297
29TAF15_26573619_Chip-Seq_HEK293_Human2.02824150
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.00997961
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00678527
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.99686021
33IGF1R_20145208_ChIP-Seq_DFB_Human1.99054534
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92238181
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91397136
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.89343004
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89330043
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88407240
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87729377
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87237595
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87043847
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.86656706
43ELK1_19687146_ChIP-ChIP_HELA_Human1.85865925
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83921298
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82237297
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73834036
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.73329815
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.70343417
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67080245
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66448683
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66372711
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66216666
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65136832
54ER_23166858_ChIP-Seq_MCF-7_Human1.65032684
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64526381
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62851006
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62215573
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61961215
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.60470803
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59419692
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59404258
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56823054
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56578064
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56080924
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55715632
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55661481
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.53201790
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52913414
69SMAD4_21799915_ChIP-Seq_A2780_Human1.50188759
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.50099956
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49160461
72* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49145569
73ZNF263_19887448_ChIP-Seq_K562_Human1.47998767
74* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46895285
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44169837
76STAT3_23295773_ChIP-Seq_U87_Human1.43706579
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.43440024
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43220069
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43220069
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43220069
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.42489861
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40333957
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39048777
84MYC_18940864_ChIP-ChIP_HL60_Human1.37851261
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37831853
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37767905
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37359539
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37223751
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.36834759
90* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.36812368
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35714512
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35105946
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35062402
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34853482
95TCF4_23295773_ChIP-Seq_U87_Human1.34495081
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33379100
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33089345
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32143827
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31558866
100BCAT_22108803_ChIP-Seq_LS180_Human1.31226882
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28735432
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28257012
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25472491
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.24928997
105TP53_22573176_ChIP-Seq_HFKS_Human1.24703505
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24650751
107CBP_20019798_ChIP-Seq_JUKART_Human1.24650751
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23750067
109GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23521094
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22933793
111CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22788974
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22525799
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21782035
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21379389
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21243801
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20059927
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19272125
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19135296
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17587542
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17093876
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17054021
122TCF4_22108803_ChIP-Seq_LS180_Human1.16974117
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15689782
124NANOG_16153702_ChIP-ChIP_HESCs_Human1.15273421
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.14683654
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.14683654
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14517544
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.13997779
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13924953
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13141856
131AR_25329375_ChIP-Seq_VCAP_Human1.12972725
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12619889
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.12289802
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12123370
135IRF1_19129219_ChIP-ChIP_H3396_Human1.11485704
136RNF2_27304074_Chip-Seq_NSC_Mouse1.10061294
137* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09906479
138NANOG_19829295_ChIP-Seq_ESCs_Human1.09541824
139SOX2_19829295_ChIP-Seq_ESCs_Human1.09541824
140RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08917111
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08303638
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06482939
143NANOG_18555785_Chip-Seq_ESCs_Mouse1.05635889
144SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05615086
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05615086
146TP63_19390658_ChIP-ChIP_HaCaT_Human1.05500965
147ARNT_22903824_ChIP-Seq_MCF-7_Human1.04941720
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04771626
149ISL1_27105846_Chip-Seq_CPCs_Mouse1.04062966
150KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02636649
151SMAD4_21741376_ChIP-Seq_EPCs_Human1.02269147
152NFE2_27457419_Chip-Seq_LIVER_Mouse1.02120075
153AHR_22903824_ChIP-Seq_MCF-7_Human1.02069423
154TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01993936
155TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01587451
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01258859
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01258859
158RUNX2_22187159_ChIP-Seq_PCA_Human1.00209768
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99602185
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98971575
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98720598
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98380252
163NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97974564
164CDX2_22108803_ChIP-Seq_LS180_Human0.97666033
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97588941
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97501139
167PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97462030
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97394545
169FLI1_21867929_ChIP-Seq_TH2_Mouse0.97252969
170GATA1_22025678_ChIP-Seq_K562_Human0.96833907
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96753936
172ESR1_21235772_ChIP-Seq_MCF-7_Human0.96641722
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.96410474
174XRN2_22483619_ChIP-Seq_HELA_Human0.95969461
175* GATA6_25053715_ChIP-Seq_YYC3_Human0.95861820
176SOX17_20123909_ChIP-Seq_XEN_Mouse0.95032546
177EST1_17652178_ChIP-ChIP_JURKAT_Human0.94984849
178SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94935494
179CHD1_26751641_Chip-Seq_LNCaP_Human0.94229956
180TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94112863
181POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93893397
182NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93576121
183* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93156555
184GATA4_25053715_ChIP-Seq_YYC3_Human0.92660475
185CRX_20693478_ChIP-Seq_RETINA_Mouse0.91728804
186JUN_21703547_ChIP-Seq_K562_Human0.90724465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.09892567
2MP0003705_abnormal_hypodermis_morpholog2.75765915
3MP0002837_dystrophic_cardiac_calcinosis2.46379471
4MP0008877_abnormal_DNA_methylation2.39277370
5MP0008438_abnormal_cutaneous_collagen2.32105085
6MP0002102_abnormal_ear_morphology2.31239927
7MP0005085_abnormal_gallbladder_physiolo2.31207166
8MP0004185_abnormal_adipocyte_glucose2.15134736
9MP0004215_abnormal_myocardial_fiber2.13847221
10MP0005330_cardiomyopathy2.04737926
11MP0005360_urolithiasis1.99153349
12MP0003806_abnormal_nucleotide_metabolis1.98037389
13MP0004272_abnormal_basement_membrane1.96018125
14MP0002938_white_spotting1.94535934
15MP0003567_abnormal_fetal_cardiomyocyte1.91356377
16MP0005666_abnormal_adipose_tissue1.88133958
17MP0008775_abnormal_heart_ventricle1.88121555
18MP0004036_abnormal_muscle_relaxation1.85381716
19MP0004147_increased_porphyrin_level1.85135526
20MP0009780_abnormal_chondrocyte_physiolo1.78700430
21MP0000427_abnormal_hair_cycle1.77723895
22MP0002160_abnormal_reproductive_system1.77000865
23MP0008058_abnormal_DNA_repair1.74721236
24MP0010352_gastrointestinal_tract_polyps1.71810527
25MP0003566_abnormal_cell_adhesion1.71448374
26MP0006072_abnormal_retinal_apoptosis1.67633882
27MP0010630_abnormal_cardiac_muscle1.67588822
28MP0004957_abnormal_blastocyst_morpholog1.67013751
29MP0008995_early_reproductive_senescence1.66535308
30MP0008057_abnormal_DNA_replication1.64653050
31MP0005367_renal/urinary_system_phenotyp1.60745321
32MP0000516_abnormal_urinary_system1.60745321
33MP0004145_abnormal_muscle_electrophysio1.60498356
34MP0005670_abnormal_white_adipose1.57969197
35MP0003136_yellow_coat_color1.53951452
36MP0005551_abnormal_eye_electrophysiolog1.53328852
37MP0006138_congestive_heart_failure1.51433156
38MP0005623_abnormal_meninges_morphology1.50022702
39MP0002139_abnormal_hepatobiliary_system1.49274489
40MP0004087_abnormal_muscle_fiber1.47508080
41MP0003718_maternal_effect1.47382315
42MP0003195_calcinosis1.45240840
43MP0005253_abnormal_eye_physiology1.43536139
44MP0005083_abnormal_biliary_tract1.43368903
45MP0005377_hearing/vestibular/ear_phenot1.43353929
46MP0003878_abnormal_ear_physiology1.43353929
47MP0003941_abnormal_skin_development1.41914884
48MP0010094_abnormal_chromosome_stability1.41084217
49MP0003693_abnormal_embryo_hatching1.41013575
50MP0003984_embryonic_growth_retardation1.39963175
51MP0000749_muscle_degeneration1.39388266
52MP0002972_abnormal_cardiac_muscle1.39115717
53MP0002088_abnormal_embryonic_growth/wei1.38969855
54MP0000751_myopathy1.37686157
55MP0005380_embryogenesis_phenotype1.36848318
56MP0001672_abnormal_embryogenesis/_devel1.36848318
57MP0000372_irregular_coat_pigmentation1.35430314
58MP0005385_cardiovascular_system_phenoty1.34797429
59MP0001544_abnormal_cardiovascular_syste1.34797429
60MP0001730_embryonic_growth_arrest1.33049847
61MP0003111_abnormal_nucleus_morphology1.32733685
62MP0010030_abnormal_orbit_morphology1.31809317
63MP0004133_heterotaxia1.31704830
64MP0005275_abnormal_skin_tensile1.31615448
65MP0003786_premature_aging1.31485903
66MP0000750_abnormal_muscle_regeneration1.30290997
67MP0005365_abnormal_bile_salt1.29470983
68MP0003077_abnormal_cell_cycle1.29229934
69MP0003828_pulmonary_edema1.29056467
70MP0005375_adipose_tissue_phenotype1.28842180
71MP0001485_abnormal_pinna_reflex1.28745122
72MP0003123_paternal_imprinting1.28716381
73MP0001286_abnormal_eye_development1.28142968
74MP0003950_abnormal_plasma_membrane1.27830264
75MP0002269_muscular_atrophy1.27742372
76MP0004197_abnormal_fetal_growth/weight/1.26972795
77MP0004130_abnormal_muscle_cell1.25456294
78MP0000537_abnormal_urethra_morphology1.24661685
79MP0002234_abnormal_pharynx_morphology1.24311607
80MP0001529_abnormal_vocalization1.23514116
81MP0009697_abnormal_copulation1.23478087
82MP0000566_synostosis1.22638223
83MP0002086_abnormal_extraembryonic_tissu1.21869244
84MP0006292_abnormal_olfactory_placode1.21131664
85MP0005646_abnormal_pituitary_gland1.20734113
86MP0000631_abnormal_neuroendocrine_gland1.20063427
87MP0003137_abnormal_impulse_conducting1.18290018
88MP0000647_abnormal_sebaceous_gland1.16615530
89MP0003646_muscle_fatigue1.16028011
90MP0003221_abnormal_cardiomyocyte_apopto1.15876535
91MP0009384_cardiac_valve_regurgitation1.15861141
92MP0002084_abnormal_developmental_patter1.15446013
93MP0010307_abnormal_tumor_latency1.14296291
94MP0002085_abnormal_embryonic_tissue1.12645828
95MP0004233_abnormal_muscle_weight1.11152407
96MP0005248_abnormal_Harderian_gland1.10810061
97MP0002127_abnormal_cardiovascular_syste1.09871563
98MP0005187_abnormal_penis_morphology1.09682918
99MP0005645_abnormal_hypothalamus_physiol1.09194292
100MP0000462_abnormal_digestive_system1.08342848
101MP0001697_abnormal_embryo_size1.07512072
102MP0003937_abnormal_limbs/digits/tail_de1.06887105
103MP0005620_abnormal_muscle_contractility1.06358836
104MP0000383_abnormal_hair_follicle1.04931636
105MP0001293_anophthalmia1.04151018
106MP0001984_abnormal_olfaction1.02833132
107MP0001661_extended_life_span1.02777514
108MP0001299_abnormal_eye_distance/1.02274822
109MP0000266_abnormal_heart_morphology1.02227037
110MP0005389_reproductive_system_phenotype1.01872109
111MP0000569_abnormal_digit_pigmentation1.01798680
112MP0004085_abnormal_heartbeat1.01405059
113MP0003942_abnormal_urinary_system1.01133996
114MP0002233_abnormal_nose_morphology1.00085147
115MP0005391_vision/eye_phenotype0.96813014
116MP0003279_aneurysm0.96493293
117MP0008932_abnormal_embryonic_tissue0.93781137
118MP0002080_prenatal_lethality0.93621658
119MP0002111_abnormal_tail_morphology0.92998892
120MP0005379_endocrine/exocrine_gland_phen0.92363927
121MP0001929_abnormal_gametogenesis0.91650965
122MP0009703_decreased_birth_body0.89773904
123MP0002210_abnormal_sex_determination0.89438766
124MP0002128_abnormal_blood_circulation0.89209614
125MP0009672_abnormal_birth_weight0.87884015
126MP0003890_abnormal_embryonic-extraembry0.87816136
127MP0002925_abnormal_cardiovascular_devel0.87467868
128MP0002877_abnormal_melanocyte_morpholog0.87154769
129MP0005332_abnormal_amino_acid0.86684136
130MP0003755_abnormal_palate_morphology0.86540848
131MP0002697_abnormal_eye_size0.86537857
132MP0010329_abnormal_lipoprotein_level0.86510718
133MP0005076_abnormal_cell_differentiation0.86264970
134MP0002106_abnormal_muscle_physiology0.86070627
135MP0009053_abnormal_anal_canal0.86029332
136MP0010678_abnormal_skin_adnexa0.85590636
137MP0000747_muscle_weakness0.85553377
138MP0002876_abnormal_thyroid_physiology0.85009663
139MP0000350_abnormal_cell_proliferation0.84953371
140MP0000003_abnormal_adipose_tissue0.83890384
141MP0004264_abnormal_extraembryonic_tissu0.83757207
142MP0000428_abnormal_craniofacial_morphol0.82747766
143MP0000653_abnormal_sex_gland0.82318584
144MP0003119_abnormal_digestive_system0.82008805
145MP0002638_abnormal_pupillary_reflex0.81720002
146MP0003935_abnormal_craniofacial_develop0.81717091
147MP0001145_abnormal_male_reproductive0.81376290
148MP0008875_abnormal_xenobiotic_pharmacok0.80815528
149MP0003385_abnormal_body_wall0.79155131
150MP0003252_abnormal_bile_duct0.77037847
151MP0009250_abnormal_appendicular_skeleto0.76740702
152MP0003115_abnormal_respiratory_system0.76033535
153MP0000013_abnormal_adipose_tissue0.75854365
154MP0005369_muscle_phenotype0.75236629
155MP0010368_abnormal_lymphatic_system0.75072472
156MP0005023_abnormal_wound_healing0.74823343
157MP0002163_abnormal_gland_morphology0.74634151
158MP0003936_abnormal_reproductive_system0.74538775
159MP0000538_abnormal_urinary_bladder0.73868462
160MP0005220_abnormal_exocrine_pancreas0.73444674
161MP0001119_abnormal_female_reproductive0.72564983
162MP0005195_abnormal_posterior_eye0.71372634

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27411120
2Chromsome breakage (HP:0040012)4.09144219
3Right ventricular cardiomyopathy (HP:0011663)4.00511946
4Ventricular tachycardia (HP:0004756)3.79137392
5Sudden death (HP:0001699)3.72110971
6Calf muscle hypertrophy (HP:0008981)3.66400410
7Myoglobinuria (HP:0002913)3.58898263
8Increased connective tissue (HP:0009025)3.36089606
9Multiple enchondromatosis (HP:0005701)3.35322450
10Abnormality of the left ventricular outflow tract (HP:0011103)3.30494803
11Subaortic stenosis (HP:0001682)3.30494803
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.27353149
13Pancreatic cysts (HP:0001737)3.12796141
14Lipoatrophy (HP:0100578)3.08466996
15Meckel diverticulum (HP:0002245)3.05055377
16Hypoglycemic coma (HP:0001325)3.03186090
17Hyperglycinuria (HP:0003108)3.00968818
18Muscle hypertrophy of the lower extremities (HP:0008968)2.94900129
19Abnormality of glycine metabolism (HP:0010895)2.94651564
20Abnormality of serine family amino acid metabolism (HP:0010894)2.94651564
21Broad metatarsal (HP:0001783)2.94185751
22Atrial fibrillation (HP:0005110)2.92736725
23Pancreatic fibrosis (HP:0100732)2.91131387
24Abnormality of the ileum (HP:0001549)2.90815095
25Abnormality of chromosome stability (HP:0003220)2.84081534
26Dilated cardiomyopathy (HP:0001644)2.77766105
27Abnormality of the renal cortex (HP:0011035)2.77352927
28Ectopic kidney (HP:0000086)2.75854958
29Abnormality of the calf musculature (HP:0001430)2.73130050
30Chronic hepatic failure (HP:0100626)2.73118580
31Abnormality of midbrain morphology (HP:0002418)2.72572160
32Molar tooth sign on MRI (HP:0002419)2.72572160
33Hyperglycinemia (HP:0002154)2.67272045
34Duplicated collecting system (HP:0000081)2.63743746
35Bilateral microphthalmos (HP:0007633)2.59189272
36Primary atrial arrhythmia (HP:0001692)2.58571944
37Intrahepatic cholestasis (HP:0001406)2.58255406
38Abnormality of the preputium (HP:0100587)2.56019816
39Muscle fiber splitting (HP:0003555)2.53062094
40Supraventricular arrhythmia (HP:0005115)2.52858809
41Nephronophthisis (HP:0000090)2.52735690
42Bifid tongue (HP:0010297)2.51596322
43True hermaphroditism (HP:0010459)2.50942938
44Supraventricular tachycardia (HP:0004755)2.50864179
45Ketoacidosis (HP:0001993)2.49287533
46Difficulty climbing stairs (HP:0003551)2.46715422
47Ankle contracture (HP:0006466)2.46457077
48Syncope (HP:0001279)2.42358156
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.40736492
50Duodenal stenosis (HP:0100867)2.38841617
51Small intestinal stenosis (HP:0012848)2.38841617
52Hyperammonemia (HP:0001987)2.38571334
53Abnormality of the renal collecting system (HP:0004742)2.36903321
54Ependymoma (HP:0002888)2.36766800
55Abnormality of the duodenum (HP:0002246)2.34218000
56Progressive muscle weakness (HP:0003323)2.34203478
57Breast hypoplasia (HP:0003187)2.32584598
58Selective tooth agenesis (HP:0001592)2.31387941
59Rhabdomyolysis (HP:0003201)2.29619002
60Abnormality of the renal medulla (HP:0100957)2.28531401
61Abnormal cartilage morphology (HP:0002763)2.25958486
62Hyporeflexia of lower limbs (HP:0002600)2.23710114
63Anophthalmia (HP:0000528)2.21240871
64Clubbing of toes (HP:0100760)2.20422065
65Missing ribs (HP:0000921)2.19955710
66Dicarboxylic aciduria (HP:0003215)2.18363313
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18363313
68Atrioventricular block (HP:0001678)2.18234560
69Colon cancer (HP:0003003)2.14128618
70Palpitations (HP:0001962)2.13637330
71Triphalangeal thumb (HP:0001199)2.12319311
72Abnormal pancreas size (HP:0012094)2.11293483
73Protrusio acetabuli (HP:0003179)2.10306370
74Absent radius (HP:0003974)2.09608143
75Cerebellar dysplasia (HP:0007033)2.09395626
76Intestinal atresia (HP:0011100)2.08357778
77Abnormality of the carotid arteries (HP:0005344)2.08283416
78Ventricular arrhythmia (HP:0004308)2.07733177
79Gaze-evoked nystagmus (HP:0000640)2.06421527
80Breast carcinoma (HP:0003002)2.06368138
81Ketosis (HP:0001946)2.05949726
82Short tibia (HP:0005736)2.02649212
83Genital tract atresia (HP:0001827)2.01978610
84Exercise-induced muscle cramps (HP:0003710)2.01143006
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.00981727
86Tubular atrophy (HP:0000092)1.99809430
87Lymphangioma (HP:0100764)1.98763545
88Vaginal atresia (HP:0000148)1.97595957
89Absent forearm bone (HP:0003953)1.97508405
90Aplasia involving forearm bones (HP:0009822)1.97508405
91Abnormal hemoglobin (HP:0011902)1.97195529
92Delayed CNS myelination (HP:0002188)1.93128416
93Glioma (HP:0009733)1.93005487
94Abnormality of DNA repair (HP:0003254)1.92372014
95Type II lissencephaly (HP:0007260)1.92255783
96Sloping forehead (HP:0000340)1.91570796
97Absent eyebrow (HP:0002223)1.90930212
98Hyperglycemia (HP:0003074)1.90385160
99Abnormality of fatty-acid metabolism (HP:0004359)1.90144512
100Abnormality of the salivary glands (HP:0010286)1.89969951
101Medial flaring of the eyebrow (HP:0010747)1.89969892
102Absent thumb (HP:0009777)1.89389265
103Rectal prolapse (HP:0002035)1.87986253
104Supernumerary bones of the axial skeleton (HP:0009144)1.87744961
105Bundle branch block (HP:0011710)1.87237340
106Biliary tract neoplasm (HP:0100574)1.87013512
107Scapular winging (HP:0003691)1.86166213
108Supernumerary ribs (HP:0005815)1.85357990
109Abnormality of serum amino acid levels (HP:0003112)1.85325972
110Pendular nystagmus (HP:0012043)1.83427215
111Hypoalphalipoproteinemia (HP:0003233)1.83059445
112Congenital malformation of the right heart (HP:0011723)1.82986030
113Double outlet right ventricle (HP:0001719)1.82986030
114Shallow orbits (HP:0000586)1.82739555
115Small hand (HP:0200055)1.82344506
116Neonatal death (HP:0003811)1.81971029
117Furrowed tongue (HP:0000221)1.81248615
118Renal cortical cysts (HP:0000803)1.81140973
119Pseudobulbar signs (HP:0002200)1.80710855
120Chorioretinal atrophy (HP:0000533)1.80288874
121Optic nerve hypoplasia (HP:0000609)1.80225887
122Lipid accumulation in hepatocytes (HP:0006561)1.79833428
123Hypoplastic labia majora (HP:0000059)1.79164173
124Nausea (HP:0002018)1.78881414
125Anencephaly (HP:0002323)1.78800361
126Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78116359
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77706167
128Abnormality of alanine metabolism (HP:0010916)1.77706167
129Hyperalaninemia (HP:0003348)1.77706167
130Pelvic girdle muscle weakness (HP:0003749)1.77509783
131Premature rupture of membranes (HP:0001788)1.77279908
132Proximal tubulopathy (HP:0000114)1.77199376
133EMG: myopathic abnormalities (HP:0003458)1.77138818
134Ragged-red muscle fibers (HP:0003200)1.76973761
135Limb-girdle muscle atrophy (HP:0003797)1.76632802
136Hyperinsulinemic hypoglycemia (HP:0000825)1.75688365
137Short thumb (HP:0009778)1.75456139
138Cutaneous finger syndactyly (HP:0010554)1.74781818
139Abnormal lung lobation (HP:0002101)1.74096946
140Hemorrhage of the eye (HP:0011885)1.73141469
141Limb-girdle muscle weakness (HP:0003325)1.72909334
142Increased hepatocellular lipid droplets (HP:0006565)1.72337789
143Concave nail (HP:0001598)1.72290828
144Hyperventilation (HP:0002883)1.71930115
145Increased serum pyruvate (HP:0003542)1.71839039
146Abnormality of glycolysis (HP:0004366)1.71839039
147Cystic liver disease (HP:0006706)1.71631068
148Neoplasm of the rectum (HP:0100743)1.71581615
149Bicornuate uterus (HP:0000813)1.71396213
150Volvulus (HP:0002580)1.71188721
151Arteriovenous malformation (HP:0100026)1.70617538
152Astigmatism (HP:0000483)1.70229262
153Premature skin wrinkling (HP:0100678)1.69634058
154Postaxial foot polydactyly (HP:0001830)1.65819292
155Preaxial foot polydactyly (HP:0001841)1.65764553
156Neoplasm of the oral cavity (HP:0100649)1.65742068
157Midline defect of the nose (HP:0004122)1.65341622
158Abnormality of the pons (HP:0007361)1.63677756
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63209039
160Abnormal biliary tract morphology (HP:0012440)1.63144830
161Abnormality of the labia minora (HP:0012880)1.62815207
162Cupped ear (HP:0000378)1.62570740
163Preaxial hand polydactyly (HP:0001177)1.62016508
164Heart block (HP:0012722)1.60869040
165Tachypnea (HP:0002789)1.60792566
166Duplication of thumb phalanx (HP:0009942)1.60634243
167Abnormality of vitamin B metabolism (HP:0004340)1.60249136
168Aneurysm (HP:0002617)1.59776284
169Abnormal biliary tract physiology (HP:0012439)1.59429584
170Bile duct proliferation (HP:0001408)1.59429584
171Abnormality of the astrocytes (HP:0100707)1.59151306
172Astrocytoma (HP:0009592)1.59151306
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.58534991
174Abnormality of the labia majora (HP:0012881)1.58210997
175Hamartoma of the eye (HP:0010568)1.57702693
176Nephroblastoma (Wilms tumor) (HP:0002667)1.57417523
177Pancreatic islet-cell hyperplasia (HP:0004510)1.57095320
178Ventricular fibrillation (HP:0001663)1.53978996
179Neoplasm of the small intestine (HP:0100833)1.53373615
180Prolonged QT interval (HP:0001657)1.53111492
181Distal lower limb muscle weakness (HP:0009053)1.52861394
182Hypolipoproteinemia (HP:0010981)1.52545526
183Abnormal atrioventricular conduction (HP:0005150)1.51052027
184Thin bony cortex (HP:0002753)1.50848039
185Abnormality of monocarboxylic acid metabolism (HP:0010996)1.50280238
186Ovarian neoplasm (HP:0100615)1.50220588
187Esophageal atresia (HP:0002032)1.50119118
188Abnormality of the 4th metacarpal (HP:0010012)1.49703356
189Cutaneous melanoma (HP:0012056)1.47035716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L3.55787498
2LATS13.24714350
3PKN23.06766827
4STK242.54665525
5BMPR1B2.51606830
6TTN2.46294306
7WEE12.32596917
8AKT32.29120926
9EPHA22.22751202
10STK32.22257830
11TTK2.15194384
12NUAK12.08216445
13BCKDK2.03235747
14ZAK1.96867259
15LMTK21.92971782
16BRSK21.91692527
17GRK11.91080626
18MST41.91024206
19NEK11.90165666
20CDK121.86232269
21NEK91.77634555
22FLT31.76608376
23EIF2AK11.75769419
24OBSCN1.70452362
25MYLK1.66892033
26CASK1.66870987
27OXSR11.66739763
28TRIB31.64063826
29FRK1.61518697
30TLK11.58000947
31PDGFRA1.52946232
32RPS6KB21.50007479
33TNIK1.47576254
34ACVR1B1.45379576
35PNCK1.45022888
36PDK41.41455063
37PDK31.41455063
38TRIM281.38709544
39STK41.36399186
40FGFR21.32166064
41CDC71.32012687
42MAP3K41.30791395
43MARK31.29657369
44PLK41.27056019
45SIK11.26456535
46ADRBK21.26446535
47MET1.26446249
48TIE11.25434203
49LATS21.24997656
50CAMK1D1.18378468
51EEF2K1.18139588
52CDK41.16231753
53PLK21.11531608
54MKNK11.06849020
55MTOR1.04839844
56MAP4K21.04470238
57AURKB1.01797962
58DMPK1.00861023
59PLK10.94531191
60MAP3K120.94372738
61TAF10.94102609
62ICK0.92189416
63STK390.89864189
64MELK0.88506245
65TGFBR10.87640805
66PAK20.87278522
67SRPK10.86468379
68PINK10.86452613
69PDGFRB0.84515835
70PDK20.83767749
71BCR0.83727263
72NEK20.82892524
73PRKCI0.82389110
74WNK30.81707800
75MAP3K80.80281873
76PRKCE0.79438435
77ERBB30.78426838
78CAMK1G0.78100835
79CDK70.76090594
80PASK0.75009613
81STK100.73685161
82ATR0.72248908
83PLK30.71961809
84INSRR0.71166620
85TYRO30.70441273
86TAOK30.69945365
87FGFR10.69729309
88VRK10.69513137
89TSSK60.69318021
90WNK40.67946782
91ALK0.67339915
92PIM10.66342582
93BRD40.63904227
94ILK0.62476087
95ROCK10.62284635
96DYRK30.61378884
97ATM0.60222685
98CHEK10.59739743
99PTK60.58889039
100KSR10.58742839
101CHEK20.58426663
102PBK0.58327446
103NLK0.57981824
104PAK30.57491959
105CSNK1D0.57198816
106MKNK20.56851774
107RIPK10.55221944
108ADRBK10.53091603
109PIK3CA0.52521645
110NEK60.52091556
111DAPK20.51337125
112FER0.51203070
113CSNK1G10.48585447
114CDK60.47950057
115PRKAA20.47732326
116ERBB40.47072550
117CSNK1E0.47069023
118TXK0.46290898
119PAK40.45783119
120EIF2AK20.45349533
121PHKG10.45287133
122PHKG20.45287133
123MUSK0.45012904
124EPHB10.43596027
125PTK20.43162767
126MAPK130.43009045
127SCYL20.40597311
128PRKAA10.40457351
129AKT20.40040254
130EIF2AK30.39022173
131CDK20.39002575
132TRPM70.38306809
133BUB10.38276212
134MAP2K10.35962553
135STK110.34702551
136PRKCG0.34623106
137EPHA40.32005562
138BRSK10.29840914
139CAMK10.29395969
140CHUK0.29079409

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.04398086
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.92749393
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90544876
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72617635
5Fatty acid degradation_Homo sapiens_hsa000712.72456879
6Fanconi anemia pathway_Homo sapiens_hsa034602.68262426
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44388738
8Fatty acid metabolism_Homo sapiens_hsa012122.43155737
9Mismatch repair_Homo sapiens_hsa034302.23959737
10Protein export_Homo sapiens_hsa030602.19866145
11One carbon pool by folate_Homo sapiens_hsa006702.02703629
12Carbon metabolism_Homo sapiens_hsa012001.99977343
13DNA replication_Homo sapiens_hsa030301.73579311
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70316551
15Butanoate metabolism_Homo sapiens_hsa006501.69051056
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63486668
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63458315
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60621145
19Phototransduction_Homo sapiens_hsa047441.56725269
20Linoleic acid metabolism_Homo sapiens_hsa005911.56290764
21Tryptophan metabolism_Homo sapiens_hsa003801.54802260
22PPAR signaling pathway_Homo sapiens_hsa033201.54414098
23Fatty acid elongation_Homo sapiens_hsa000621.53302148
24Lysine degradation_Homo sapiens_hsa003101.50530673
25Caffeine metabolism_Homo sapiens_hsa002321.49735251
26Pyruvate metabolism_Homo sapiens_hsa006201.48913960
27Biosynthesis of amino acids_Homo sapiens_hsa012301.48574650
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48105590
29Hedgehog signaling pathway_Homo sapiens_hsa043401.47011862
30Sulfur relay system_Homo sapiens_hsa041221.45744049
31Oxidative phosphorylation_Homo sapiens_hsa001901.43919592
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40560785
33Homologous recombination_Homo sapiens_hsa034401.37315867
34Nucleotide excision repair_Homo sapiens_hsa034201.35429483
35RNA transport_Homo sapiens_hsa030131.34451528
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34415093
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.33042077
38Selenocompound metabolism_Homo sapiens_hsa004501.30626750
39Nitrogen metabolism_Homo sapiens_hsa009101.29055358
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28521917
41Fatty acid biosynthesis_Homo sapiens_hsa000611.28411637
42ECM-receptor interaction_Homo sapiens_hsa045121.22909423
43Steroid biosynthesis_Homo sapiens_hsa001001.21195705
44Peroxisome_Homo sapiens_hsa041461.20952849
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20203303
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18901061
47beta-Alanine metabolism_Homo sapiens_hsa004101.16197202
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15114836
49Arginine biosynthesis_Homo sapiens_hsa002201.10939439
50Mineral absorption_Homo sapiens_hsa049781.09946037
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08382463
52Dilated cardiomyopathy_Homo sapiens_hsa054141.07608219
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06495051
54Cell cycle_Homo sapiens_hsa041101.06024073
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05895797
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.03299748
57RNA polymerase_Homo sapiens_hsa030201.01501221
58Arginine and proline metabolism_Homo sapiens_hsa003301.00476714
59Ether lipid metabolism_Homo sapiens_hsa005651.00076918
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00025671
61Glutathione metabolism_Homo sapiens_hsa004800.97588117
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96308191
63Small cell lung cancer_Homo sapiens_hsa052220.96199843
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95701465
65Circadian rhythm_Homo sapiens_hsa047100.94234950
66Parkinsons disease_Homo sapiens_hsa050120.92396263
67Systemic lupus erythematosus_Homo sapiens_hsa053220.92386327
68Purine metabolism_Homo sapiens_hsa002300.91834408
69Fat digestion and absorption_Homo sapiens_hsa049750.91271192
70Tight junction_Homo sapiens_hsa045300.90885783
71Huntingtons disease_Homo sapiens_hsa050160.89396185
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88752817
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87208283
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.87140864
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.84784572
76Starch and sucrose metabolism_Homo sapiens_hsa005000.84694969
77Regulation of autophagy_Homo sapiens_hsa041400.81559786
78Proteasome_Homo sapiens_hsa030500.81311717
79Base excision repair_Homo sapiens_hsa034100.80212266
80Spliceosome_Homo sapiens_hsa030400.80185538
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78777788
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78449869
83Hippo signaling pathway_Homo sapiens_hsa043900.78286247
84Adherens junction_Homo sapiens_hsa045200.77591261
85Basal cell carcinoma_Homo sapiens_hsa052170.76709129
86Pyrimidine metabolism_Homo sapiens_hsa002400.76050017
87Focal adhesion_Homo sapiens_hsa045100.75448618
88AMPK signaling pathway_Homo sapiens_hsa041520.74867956
89ABC transporters_Homo sapiens_hsa020100.73950969
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72570927
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71885883
92Pentose phosphate pathway_Homo sapiens_hsa000300.71740126
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71068223
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68780608
95Insulin resistance_Homo sapiens_hsa049310.67494419
96Vitamin digestion and absorption_Homo sapiens_hsa049770.66667344
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.66654396
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66408562
99Protein digestion and absorption_Homo sapiens_hsa049740.66260069
100MicroRNAs in cancer_Homo sapiens_hsa052060.65928703
101Phenylalanine metabolism_Homo sapiens_hsa003600.65708706
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.63773206
103Cardiac muscle contraction_Homo sapiens_hsa042600.63366764
104Sphingolipid metabolism_Homo sapiens_hsa006000.62908597
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62892402
106Taste transduction_Homo sapiens_hsa047420.62791565
107Viral myocarditis_Homo sapiens_hsa054160.61477502
108Glycerolipid metabolism_Homo sapiens_hsa005610.61116930
109Sulfur metabolism_Homo sapiens_hsa009200.60729034
110Chemical carcinogenesis_Homo sapiens_hsa052040.60600331
111Folate biosynthesis_Homo sapiens_hsa007900.60531641
112TGF-beta signaling pathway_Homo sapiens_hsa043500.59646032
113Non-homologous end-joining_Homo sapiens_hsa034500.58505855
114RNA degradation_Homo sapiens_hsa030180.58471678
115Basal transcription factors_Homo sapiens_hsa030220.58037953
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58035484
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57491910
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.55243652
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55219364
120Wnt signaling pathway_Homo sapiens_hsa043100.53101410
121mRNA surveillance pathway_Homo sapiens_hsa030150.52344732
122Alcoholism_Homo sapiens_hsa050340.52029551
123Melanoma_Homo sapiens_hsa052180.51207857
124Tyrosine metabolism_Homo sapiens_hsa003500.51068874
125Fructose and mannose metabolism_Homo sapiens_hsa000510.50359852
126Alzheimers disease_Homo sapiens_hsa050100.49722071
127Viral carcinogenesis_Homo sapiens_hsa052030.48570703
128Nicotine addiction_Homo sapiens_hsa050330.47811820
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.47779308
130Ovarian steroidogenesis_Homo sapiens_hsa049130.46977129
131Oocyte meiosis_Homo sapiens_hsa041140.44721651
132Galactose metabolism_Homo sapiens_hsa000520.43933945
133p53 signaling pathway_Homo sapiens_hsa041150.43245648
134Metabolic pathways_Homo sapiens_hsa011000.42493290
135Proteoglycans in cancer_Homo sapiens_hsa052050.40720716
136Vitamin B6 metabolism_Homo sapiens_hsa007500.39913206
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38566921
138Retinol metabolism_Homo sapiens_hsa008300.38133018

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