SYF2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.16551635
2regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.71439475
3regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.59343569
4negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)5.57646884
5membrane budding (GO:0006900)5.39683865
6regulation of actin filament-based movement (GO:1903115)5.14335565
7regulation of cardiac muscle cell contraction (GO:0086004)4.96799779
8sarcomere organization (GO:0045214)4.71449663
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.67941672
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.64641143
11regulation of relaxation of muscle (GO:1901077)4.63278678
12coronary vasculature morphogenesis (GO:0060977)4.59500428
13regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.51112142
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.36390313
15cardiac muscle cell development (GO:0055013)4.34208453
16regulation of cell communication by electrical coupling (GO:0010649)4.32368907
17cell communication involved in cardiac conduction (GO:0086065)4.32327742
18ventricular cardiac muscle cell action potential (GO:0086005)4.15392367
19regulation of cardiac muscle contraction (GO:0055117)4.10500937
20neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.09086843
21cardiac cell development (GO:0055006)4.03733001
22response to redox state (GO:0051775)3.99526772
23ribonucleoprotein complex disassembly (GO:0032988)3.98340623
24cell communication by electrical coupling (GO:0010644)3.95878692
25striatum development (GO:0021756)3.95089292
26ventricular cardiac muscle cell development (GO:0055015)3.92136998
27negative regulation of calcium ion transmembrane transport (GO:1903170)3.91947528
28negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.91947528
29regulation of striated muscle contraction (GO:0006942)3.88680771
30cardiac myofibril assembly (GO:0055003)3.87909244
31heart contraction (GO:0060047)3.83925129
32heart process (GO:0003015)3.83925129
33righting reflex (GO:0060013)3.80658358
34vesicle targeting (GO:0006903)3.77163911
35viral mRNA export from host cell nucleus (GO:0046784)3.73674332
36response to inactivity (GO:0014854)3.70901720
37cellular response to interleukin-6 (GO:0071354)3.68993450
38regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.67603978
39anterior/posterior axis specification, embryo (GO:0008595)3.62862038
40neuronal action potential propagation (GO:0019227)3.57470734
41cardiac muscle hypertrophy (GO:0003300)3.52900325
42negative regulation of cation channel activity (GO:2001258)3.52508026
43cardiac muscle contraction (GO:0060048)3.49756122
44regulation of phospholipase A2 activity (GO:0032429)3.44850396
45myofibril assembly (GO:0030239)3.44282917
46lipid particle organization (GO:0034389)3.41062400
47regulation of heart rate (GO:0002027)3.40363586
48positive regulation of action potential (GO:0045760)3.37514426
49calcium-mediated signaling using intracellular calcium source (GO:0035584)3.36997786
50striated muscle hypertrophy (GO:0014897)3.33970835
51phospholipid scrambling (GO:0017121)3.31407122
52mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.23296471
53adrenergic receptor signaling pathway (GO:0071875)3.21589422
54organelle disassembly (GO:1903008)3.20200968
55growth hormone secretion (GO:0030252)3.19364753
56urinary tract smooth muscle contraction (GO:0014848)3.16563060
57localization within membrane (GO:0051668)3.16538946
58regulation of cardioblast differentiation (GO:0051890)3.15666790
59sequestering of metal ion (GO:0051238)3.12725103
60positive regulation of heart rate (GO:0010460)3.12370540
61detection of calcium ion (GO:0005513)3.09116480
62proteasome assembly (GO:0043248)3.08138846
63sialylation (GO:0097503)3.04884335
64endoderm formation (GO:0001706)3.03772595
65activation of protein kinase A activity (GO:0034199)3.01794344
66adult heart development (GO:0007512)2.99528619
67response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.96203455
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94005246
69negative regulation of heart rate (GO:0010459)2.92630231
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.92069179
71detection of molecule of bacterial origin (GO:0032490)2.91977117
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91782275
73retina layer formation (GO:0010842)2.91691558
74muscle filament sliding (GO:0030049)2.90866438
75actin-myosin filament sliding (GO:0033275)2.90866438
76muscle tissue morphogenesis (GO:0060415)2.89787218
77cardiac muscle cell action potential (GO:0086001)2.89703911
78fat-soluble vitamin biosynthetic process (GO:0042362)2.89571281
79response to interleukin-6 (GO:0070741)2.87893072
80cardiac muscle tissue morphogenesis (GO:0055008)2.86151971
81regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84608433
82hemoglobin metabolic process (GO:0020027)2.83542065
83muscle hypertrophy (GO:0014896)2.82767175
84negative regulation of cAMP-mediated signaling (GO:0043951)2.80433889
85positive regulation of cardiac muscle cell differentiation (GO:2000727)2.80372165
86cytoplasmic microtubule organization (GO:0031122)2.79508033
87positive regulation of cardiac muscle tissue growth (GO:0055023)2.78374173
88actomyosin structure organization (GO:0031032)2.77511625
89carnitine shuttle (GO:0006853)2.76915209
90tongue development (GO:0043586)2.76399657
91NADH metabolic process (GO:0006734)2.76266404
92negative regulation of axon extension involved in axon guidance (GO:0048843)2.75777035
93regulation of membrane repolarization (GO:0060306)2.74296853
94left/right axis specification (GO:0070986)2.74182822
95cardiac muscle cell action potential involved in contraction (GO:0086002)2.71704956
96auditory receptor cell stereocilium organization (GO:0060088)2.71439780
97positive regulation of sodium ion transport (GO:0010765)2.69804928
98negative regulation of viral entry into host cell (GO:0046597)2.66473283
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.62029029
100regulation of voltage-gated calcium channel activity (GO:1901385)2.61785851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.41578256
2GBX2_23144817_ChIP-Seq_PC3_Human3.33950118
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10939828
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.07735414
5EZH2_22144423_ChIP-Seq_EOC_Human2.65260822
6TAF15_26573619_Chip-Seq_HEK293_Human2.44038942
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42578371
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.39108886
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34773252
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28232833
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.28119045
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23678258
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.21574359
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18498152
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.16172503
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91711629
17SMAD4_21799915_ChIP-Seq_A2780_Human1.90251836
18TP53_16413492_ChIP-PET_HCT116_Human1.90022628
19FUS_26573619_Chip-Seq_HEK293_Human1.86244499
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.84602249
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83969322
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80440972
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80153814
24P300_19829295_ChIP-Seq_ESCs_Human1.73403108
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71256628
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61080300
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61063210
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58401422
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.56706025
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50357740
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.49753249
32ER_23166858_ChIP-Seq_MCF-7_Human1.49356104
33TP53_18474530_ChIP-ChIP_U2OS_Human1.47801707
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42553727
35IGF1R_20145208_ChIP-Seq_DFB_Human1.42546282
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42541172
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42279762
38CBP_20019798_ChIP-Seq_JUKART_Human1.42279762
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38883654
40NANOG_19829295_ChIP-Seq_ESCs_Human1.38241963
41SOX2_19829295_ChIP-Seq_ESCs_Human1.38241963
42CJUN_26792858_Chip-Seq_BT549_Human1.38064658
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37707618
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37541917
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36852505
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35314904
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34437475
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34372663
49AR_25329375_ChIP-Seq_VCAP_Human1.34067322
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33880828
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33626174
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.32649582
53RNF2_27304074_Chip-Seq_NSC_Mouse1.32558085
54BCAT_22108803_ChIP-Seq_LS180_Human1.31225301
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30631838
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29582061
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.29245427
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.27582336
59TCF4_23295773_ChIP-Seq_U87_Human1.27413694
60EWS_26573619_Chip-Seq_HEK293_Human1.25477374
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25333337
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25002281
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24275378
64RUNX2_22187159_ChIP-Seq_PCA_Human1.22535007
65SMAD4_21741376_ChIP-Seq_HESCs_Human1.20832646
66STAT3_23295773_ChIP-Seq_U87_Human1.20778175
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20033966
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.19924386
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19859861
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19138898
71TCF4_22108803_ChIP-Seq_LS180_Human1.19089909
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.18213164
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.17315415
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16818724
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15924487
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.14399364
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.13454627
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.12941881
79HNFA_21074721_ChIP-Seq_CACO-2_Human1.11374296
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.10840080
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.10375167
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10020120
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.09883449
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09351497
85AHR_22903824_ChIP-Seq_MCF-7_Human1.09265066
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.09171464
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09001927
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07026120
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06581999
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06581999
91TBL1_22424771_ChIP-Seq_293T_Human1.06000731
92NFYB_21822215_ChIP-Seq_K562_Human1.05612507
93CDX2_22108803_ChIP-Seq_LS180_Human1.05307548
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04657741
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.03785700
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01997260
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01344730
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01245086
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00512101
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99101008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.15349286
2MP0003806_abnormal_nucleotide_metabolis4.55328000
3MP0005451_abnormal_body_composition3.97721802
4MP0004215_abnormal_myocardial_fiber3.93058476
5MP0004145_abnormal_muscle_electrophysio3.78465276
6MP0000751_myopathy3.54873286
7MP0003195_calcinosis3.50481851
8MP0004036_abnormal_muscle_relaxation2.88154735
9MP0004084_abnormal_cardiac_muscle2.73146211
10MP0006276_abnormal_autonomic_nervous2.66081323
11MP0005423_abnormal_somatic_nervous2.40729227
12MP0005670_abnormal_white_adipose2.27601490
13MP0000013_abnormal_adipose_tissue2.16465567
14MP0003137_abnormal_impulse_conducting2.15872844
15MP0002876_abnormal_thyroid_physiology2.15496338
16MP0002972_abnormal_cardiac_muscle2.10461324
17MP0004510_myositis2.04676992
18MP0000749_muscle_degeneration1.90955793
19MP0009697_abnormal_copulation1.81880878
20MP0004484_altered_response_of1.81780261
21MP0002837_dystrophic_cardiac_calcinosis1.80671045
22MP0005409_darkened_coat_color1.78875262
23MP0004085_abnormal_heartbeat1.77647989
24MP0005620_abnormal_muscle_contractility1.74194229
25MP0002332_abnormal_exercise_endurance1.74006330
26MP0000750_abnormal_muscle_regeneration1.72662368
27MP0005330_cardiomyopathy1.72271253
28MP0002638_abnormal_pupillary_reflex1.63341562
29MP0002127_abnormal_cardiovascular_syste1.62749930
30MP0006072_abnormal_retinal_apoptosis1.59785263
31MP0002106_abnormal_muscle_physiology1.58388290
32MP0000003_abnormal_adipose_tissue1.55579231
33MP0004233_abnormal_muscle_weight1.53101500
34MP0008775_abnormal_heart_ventricle1.47594945
35MP0003279_aneurysm1.46620542
36MP0005385_cardiovascular_system_phenoty1.46542877
37MP0001544_abnormal_cardiovascular_syste1.46542877
38MP0009250_abnormal_appendicular_skeleto1.44694978
39MP0003646_muscle_fatigue1.41077827
40MP0001835_abnormal_antigen_presentation1.40494781
41MP0000372_irregular_coat_pigmentation1.38934589
42MP0005369_muscle_phenotype1.38173331
43MP0004087_abnormal_muscle_fiber1.37493419
44MP0004272_abnormal_basement_membrane1.35542372
45MP0008438_abnormal_cutaneous_collagen1.34134080
46MP0005248_abnormal_Harderian_gland1.28633488
47MP0005084_abnormal_gallbladder_morpholo1.26981752
48MP0009046_muscle_twitch1.24660869
49MP0001984_abnormal_olfaction1.24253763
50MP0010386_abnormal_urinary_bladder1.22768331
51MP0000343_altered_response_to1.18467161
52MP0005275_abnormal_skin_tensile1.16821648
53MP0003890_abnormal_embryonic-extraembry1.15497197
54MP0001486_abnormal_startle_reflex1.08565077
55MP0002102_abnormal_ear_morphology1.07734821
56MP0005375_adipose_tissue_phenotype1.03835238
57MP0000762_abnormal_tongue_morphology1.01157846
58MP0003221_abnormal_cardiomyocyte_apopto1.00300219
59MP0010630_abnormal_cardiac_muscle0.99983098
60MP0005266_abnormal_metabolism0.99527977
61MP0006138_congestive_heart_failure0.99065129
62MP0002269_muscular_atrophy0.96998146
63MP0002736_abnormal_nociception_after0.95423935
64MP0005551_abnormal_eye_electrophysiolog0.95406236
65MP0001986_abnormal_taste_sensitivity0.94204523
66MP0002108_abnormal_muscle_morphology0.92795766
67MP0001666_abnormal_nutrient_absorption0.92170624
68MP0001968_abnormal_touch/_nociception0.89963867
69MP0000747_muscle_weakness0.88298726
70MP0001440_abnormal_grooming_behavior0.87171331
71MP0003045_fibrosis0.86584314
72MP0000759_abnormal_skeletal_muscle0.86579432
73MP0002734_abnormal_mechanical_nocicepti0.86267872
74MP0008004_abnormal_stomach_pH0.85847105
75MP0000639_abnormal_adrenal_gland0.84657060
76MP0002168_other_aberrant_phenotype0.84364528
77MP0001529_abnormal_vocalization0.80591425
78MP0001661_extended_life_span0.78969606
79MP0002735_abnormal_chemical_nociception0.78533260
80MP0002928_abnormal_bile_duct0.76662027
81MP0009384_cardiac_valve_regurgitation0.76624554
82MP0006036_abnormal_mitochondrial_physio0.75909347
83MP0001501_abnormal_sleep_pattern0.75826254
84MP0004142_abnormal_muscle_tone0.75312338
85MP0010368_abnormal_lymphatic_system0.75043608
86MP0000230_abnormal_systemic_arterial0.72746856
87MP0002295_abnormal_pulmonary_circulatio0.71111949
88MP0003937_abnormal_limbs/digits/tail_de0.69870349
89MP0001727_abnormal_embryo_implantation0.68868862
90MP0005253_abnormal_eye_physiology0.67698449
91MP0002254_reproductive_system_inflammat0.66513727
92MP0000266_abnormal_heart_morphology0.64180789
93MP0000383_abnormal_hair_follicle0.63939699
94MP0009745_abnormal_behavioral_response0.63643191
95MP0001502_abnormal_circadian_rhythm0.61224474
96MP0002075_abnormal_coat/hair_pigmentati0.60804439
97MP0000371_diluted_coat_color0.60798658
98MP0003868_abnormal_feces_composition0.60760354
99MP0005165_increased_susceptibility_to0.59567613
100MP0002138_abnormal_hepatobiliary_system0.59445260

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)5.27283715
2Sudden death (HP:0001699)5.19972484
3Syncope (HP:0001279)4.66164746
4Split foot (HP:0001839)4.33143193
5Muscle fiber splitting (HP:0003555)4.20961005
6Congenital malformation of the right heart (HP:0011723)4.18343097
7Double outlet right ventricle (HP:0001719)4.18343097
8Palpitations (HP:0001962)4.09073815
9Right ventricular cardiomyopathy (HP:0011663)4.06665504
10Myotonia (HP:0002486)3.93537547
11Primary atrial arrhythmia (HP:0001692)3.89775410
12Atrial fibrillation (HP:0005110)3.88642332
13Supraventricular tachycardia (HP:0004755)3.83974389
14Bile duct proliferation (HP:0001408)3.81760137
15Abnormal biliary tract physiology (HP:0012439)3.81760137
16Bundle branch block (HP:0011710)3.72243178
17Supraventricular arrhythmia (HP:0005115)3.72046639
18Ventricular arrhythmia (HP:0004308)3.52827837
19Enlarged epiphyses (HP:0010580)3.49007153
20Long nose (HP:0003189)3.47449641
21Ventricular tachycardia (HP:0004756)3.34806469
22Prolonged QT interval (HP:0001657)3.34320188
23Hyporeflexia of lower limbs (HP:0002600)3.31051655
24Decreased muscle mass (HP:0003199)3.25381753
25Thin bony cortex (HP:0002753)3.13320987
26Periauricular skin pits (HP:0100277)3.00410364
27Preauricular pit (HP:0004467)3.00410364
28Lipoatrophy (HP:0100578)2.96953986
29Pancreatic cysts (HP:0001737)2.96925557
30Abnormal EKG (HP:0003115)2.90829377
31Ventricular fibrillation (HP:0001663)2.81737336
32Pigmentary retinal degeneration (HP:0001146)2.78734121
33Short middle phalanx of the 5th finger (HP:0004220)2.77751403
34Abnormality of the costochondral junction (HP:0000919)2.73950531
35Widely patent fontanelles and sutures (HP:0004492)2.59167808
36Skin pits (HP:0100276)2.58861922
37Delayed epiphyseal ossification (HP:0002663)2.58411836
38Atrioventricular block (HP:0001678)2.55481171
39Metaphyseal dysplasia (HP:0100255)2.45487978
40Pheochromocytoma (HP:0002666)2.38497418
41Abnormality of the calf musculature (HP:0001430)2.38340123
42Intestinal atresia (HP:0011100)2.38262562
43Methylmalonic acidemia (HP:0002912)2.35662312
44Drooling (HP:0002307)2.35228761
45Abnormality of midbrain morphology (HP:0002418)2.29341278
46Molar tooth sign on MRI (HP:0002419)2.29341278
47Left ventricular hypertrophy (HP:0001712)2.26980288
48Hyperventilation (HP:0002883)2.25395940
49Microvesicular hepatic steatosis (HP:0001414)2.25303540
50Heart block (HP:0012722)2.24515210
51Calf muscle hypertrophy (HP:0008981)2.23075700
52Gonadotropin excess (HP:0000837)2.19733821
53Atonic seizures (HP:0010819)2.17869085
54Neuroendocrine neoplasm (HP:0100634)2.13754102
55Excessive salivation (HP:0003781)2.13177496
56Pancreatic fibrosis (HP:0100732)2.12041220
57Abnormality of homocysteine metabolism (HP:0010919)2.09678425
58Homocystinuria (HP:0002156)2.09678425
59Bifid tongue (HP:0010297)2.09501250
60EMG: myopathic abnormalities (HP:0003458)2.08975658
61Median cleft lip (HP:0000161)2.06875352
62Flat occiput (HP:0005469)2.05526186
63Dilated cardiomyopathy (HP:0001644)2.05372376
64Methylmalonic aciduria (HP:0012120)2.05072695
65Cortical dysplasia (HP:0002539)2.02141268
66Central scotoma (HP:0000603)2.01745543
67Acute necrotizing encephalopathy (HP:0006965)1.96170631
68Abnormal pancreas size (HP:0012094)1.94688354
69Abnormal atrioventricular conduction (HP:0005150)1.91610241
70Transposition of the great arteries (HP:0001669)1.90974917
71Abnormal connection of the cardiac segments (HP:0011545)1.90974917
72Abnormal ventriculo-arterial connection (HP:0011563)1.90974917
73Cerebral palsy (HP:0100021)1.89914986
74Tinnitus (HP:0000360)1.87947587
75Exercise-induced muscle cramps (HP:0003710)1.87254309
76Nephronophthisis (HP:0000090)1.86622019
77Anomalous pulmonary venous return (HP:0010772)1.85653052
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.84295067
79Tongue fasciculations (HP:0001308)1.82546511
80Abnormality of the neuromuscular junction (HP:0003398)1.82519557
81Fatigable weakness (HP:0003473)1.82519557
82Supernumerary spleens (HP:0009799)1.81171400
83Aplastic anemia (HP:0001915)1.80564243
84Focal seizures (HP:0007359)1.78391799
85Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76008430
86Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75686853
87Delayed gross motor development (HP:0002194)1.75290204
88Muscle fibrillation (HP:0010546)1.74887308
89True hermaphroditism (HP:0010459)1.73854958
90Frequent falls (HP:0002359)1.72881015
91Abnormality of the parathyroid morphology (HP:0011766)1.71605738
92Abnormality of the aortic arch (HP:0012303)1.68719847
93Progressive macrocephaly (HP:0004481)1.66559670
94Abnormality of the renal medulla (HP:0100957)1.65726018
95Myocardial infarction (HP:0001658)1.65485051
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65192323
97Megaloblastic anemia (HP:0001889)1.64620751
98Abnormal mitochondria in muscle tissue (HP:0008316)1.64043567
99Muscular dystrophy (HP:0003560)1.63447126
100Increased serum pyruvate (HP:0003542)1.62564027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K28.51118550
2EIF2AK34.23239399
3MAP3K64.12462046
4MUSK4.06016595
5MYLK3.94593779
6BLK3.36844287
7OBSCN2.76935112
8TRIM282.34281465
9ERBB42.29310312
10ERBB32.05353621
11MAP3K121.70429132
12CASK1.62133543
13FRK1.57290314
14PAK31.56587017
15TNIK1.55536630
16BCKDK1.52668676
17ZAK1.43095356
18PRKCE1.37082881
19LMTK21.33015534
20PIK3CA1.25136140
21PINK11.24076581
22CAMK2D1.22715111
23WNK31.16125543
24PDK21.15890258
25DMPK1.14365569
26MAP3K41.12112481
27TEC1.10511207
28MARK11.07188201
29NEK11.04151332
30TTN1.03066174
31PHKG11.02329058
32PHKG21.02329058
33BRD40.98185680
34PBK0.97363210
35BCR0.96300464
36ITK0.96073061
37GRK10.87583029
38TGFBR20.84962226
39PIK3CG0.78978330
40EIF2AK20.74291430
41CAMK2A0.67546169
42PRKG10.67543085
43MAP3K50.64776217
44STK40.64033001
45INSRR0.63822763
46SYK0.62604557
47PRKAA20.60022686
48MAPK70.58439960
49PRKACA0.57624924
50MAPK120.53661641
51PRKD10.53109525
52ERBB20.52426040
53NUAK10.51032700
54PRKAA10.50721827
55PRKACG0.50171480
56MAP2K70.47516241
57BMPR20.46115321
58ROCK10.46096052
59FER0.46063239
60BMPR1B0.44372162
61ABL10.40701283
62GRK70.40544337
63LYN0.39965557
64PRKG20.38492666
65RPS6KA50.35848208
66PKN10.35434147
67PRKCZ0.35243233
68ADRBK20.35059884
69IGF1R0.33969963
70PLK40.33536065
71KDR0.33438668
72EGFR0.32856648
73CAMK2B0.30965886
74ROCK20.30851967
75FLT30.29995333
76DYRK20.29911318
77PLK20.28773723
78MAP2K10.28612369
79DDR20.28004171
80LIMK10.27971535
81CAMK2G0.27748266
82MAPK130.27482598
83PTK2B0.27379600
84IKBKB0.26713262
85EPHA40.26523707
86MAP2K30.26131448
87MAPK40.25479149
88MAP2K60.25155746
89DAPK30.23482717
90TGFBR10.21660757
91ZAP700.21512696
92DAPK20.21106723
93PRKCA0.21104597
94TRPM70.20728632
95MAP3K70.20641335
96NEK60.20548788
97ADRBK10.20510612
98INSR0.17771953
99MAP3K30.17673793
100ATR0.16406638

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.68183806
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.12827102
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.08510816
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.04961492
5Dilated cardiomyopathy_Homo sapiens_hsa054142.70189240
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.62689829
7Regulation of autophagy_Homo sapiens_hsa041402.48314305
8Propanoate metabolism_Homo sapiens_hsa006402.36399121
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11578317
10Circadian rhythm_Homo sapiens_hsa047102.03059071
11Asthma_Homo sapiens_hsa053101.90863576
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84787551
13Cardiac muscle contraction_Homo sapiens_hsa042601.81529596
14GABAergic synapse_Homo sapiens_hsa047271.59386925
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52893852
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51406276
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44513264
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44454982
19Salivary secretion_Homo sapiens_hsa049701.43266120
20Viral myocarditis_Homo sapiens_hsa054161.39076728
21Renin secretion_Homo sapiens_hsa049241.32355939
22Starch and sucrose metabolism_Homo sapiens_hsa005001.31660367
23Serotonergic synapse_Homo sapiens_hsa047261.31370964
24Circadian entrainment_Homo sapiens_hsa047131.29332333
25Parkinsons disease_Homo sapiens_hsa050121.26409776
26Linoleic acid metabolism_Homo sapiens_hsa005911.26092101
27Graft-versus-host disease_Homo sapiens_hsa053321.24443329
28Morphine addiction_Homo sapiens_hsa050321.24406200
29Taste transduction_Homo sapiens_hsa047421.18978127
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17502549
31Oxidative phosphorylation_Homo sapiens_hsa001901.15515916
32Autoimmune thyroid disease_Homo sapiens_hsa053201.12761732
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.12483108
34Olfactory transduction_Homo sapiens_hsa047401.11755850
35Allograft rejection_Homo sapiens_hsa053301.11147245
36Insulin secretion_Homo sapiens_hsa049111.09434380
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.07178556
38Pancreatic secretion_Homo sapiens_hsa049721.05718143
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.03676031
40RNA polymerase_Homo sapiens_hsa030201.03207422
41Type I diabetes mellitus_Homo sapiens_hsa049401.02955234
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98631689
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97581344
44Ovarian steroidogenesis_Homo sapiens_hsa049130.96246822
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95262641
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94392858
47Glutamatergic synapse_Homo sapiens_hsa047240.94226224
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90899045
49Staphylococcus aureus infection_Homo sapiens_hsa051500.90106815
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.84498836
51Collecting duct acid secretion_Homo sapiens_hsa049660.84050407
52Cocaine addiction_Homo sapiens_hsa050300.82130685
53Dopaminergic synapse_Homo sapiens_hsa047280.80990670
54Glutathione metabolism_Homo sapiens_hsa004800.80846047
55Gastric acid secretion_Homo sapiens_hsa049710.79489673
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78870786
57Cholinergic synapse_Homo sapiens_hsa047250.78047604
58Sulfur metabolism_Homo sapiens_hsa009200.75650873
59cAMP signaling pathway_Homo sapiens_hsa040240.73143603
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71084235
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69102817
62Phototransduction_Homo sapiens_hsa047440.68796377
63Huntingtons disease_Homo sapiens_hsa050160.68521553
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66937219
65Ether lipid metabolism_Homo sapiens_hsa005650.66586704
66Nicotine addiction_Homo sapiens_hsa050330.65023137
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64014192
68Phagosome_Homo sapiens_hsa041450.63971713
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61998879
70Calcium signaling pathway_Homo sapiens_hsa040200.60465815
71Arachidonic acid metabolism_Homo sapiens_hsa005900.60443914
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58194480
73Platelet activation_Homo sapiens_hsa046110.57595897
74Steroid biosynthesis_Homo sapiens_hsa001000.56945808
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56059153
76Amphetamine addiction_Homo sapiens_hsa050310.54553712
77Carbon metabolism_Homo sapiens_hsa012000.54261799
78Oxytocin signaling pathway_Homo sapiens_hsa049210.53763920
79Rheumatoid arthritis_Homo sapiens_hsa053230.53583927
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53329883
81Melanogenesis_Homo sapiens_hsa049160.52445440
82Alzheimers disease_Homo sapiens_hsa050100.51189710
83Tryptophan metabolism_Homo sapiens_hsa003800.50928899
84Hedgehog signaling pathway_Homo sapiens_hsa043400.48120330
85African trypanosomiasis_Homo sapiens_hsa051430.46478713
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46465587
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43785335
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41145742
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40705316
90Arginine biosynthesis_Homo sapiens_hsa002200.38049717
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37601138
92Tight junction_Homo sapiens_hsa045300.35663685
93Insulin resistance_Homo sapiens_hsa049310.35620328
94ECM-receptor interaction_Homo sapiens_hsa045120.35297246
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33481277
96Basal cell carcinoma_Homo sapiens_hsa052170.29231200
97Butanoate metabolism_Homo sapiens_hsa006500.29067692
98Peroxisome_Homo sapiens_hsa041460.28850109
99Pertussis_Homo sapiens_hsa051330.28230610
100Wnt signaling pathway_Homo sapiens_hsa043100.27020063

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