SYK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* B cell receptor signaling pathway (GO:0050853)6.27510741
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.36126714
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.36126714
4modulation by symbiont of host immune response (GO:0052553)5.36126714
5positive regulation by symbiont of host defense response (GO:0052509)5.36126714
6modulation by symbiont of host defense response (GO:0052031)5.36126714
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.36126714
8antigen processing and presentation of endogenous antigen (GO:0019883)5.01118556
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97432301
10regulation of interferon-beta biosynthetic process (GO:0045357)4.92441039
11detection of other organism (GO:0098543)4.87622971
12regulation of B cell receptor signaling pathway (GO:0050855)4.87467080
13detection of bacterium (GO:0016045)4.64703597
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45180794
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45180794
16* positive regulation of gamma-delta T cell activation (GO:0046645)4.39573641
17cellular response to zinc ion (GO:0071294)4.34051832
18immunoglobulin mediated immune response (GO:0016064)4.31495510
19respiratory burst (GO:0045730)4.30247074
20* regulation of B cell differentiation (GO:0045577)4.17711725
21* positive regulation of B cell differentiation (GO:0045579)4.16710402
22positive regulation of interferon-alpha production (GO:0032727)4.14289923
23detection of external biotic stimulus (GO:0098581)4.09148493
24regulation of interferon-alpha production (GO:0032647)3.93212961
25microglial cell activation (GO:0001774)3.92251919
26response to peptidoglycan (GO:0032494)3.88904963
27detection of molecule of bacterial origin (GO:0032490)3.81973621
28defense response to protozoan (GO:0042832)3.80991775
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.78172112
30serine transport (GO:0032329)3.77992366
31* neutrophil activation (GO:0042119)3.77472195
32negative regulation of erythrocyte differentiation (GO:0045647)3.74094349
33negative regulation of phagocytosis (GO:0050765)3.72428741
34mature B cell differentiation (GO:0002335)3.66929484
35* granulocyte activation (GO:0036230)3.66671100
36B cell proliferation (GO:0042100)3.64770666
37* macrophage activation involved in immune response (GO:0002281)3.64439587
38detection of biotic stimulus (GO:0009595)3.63145090
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.59946418
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59673492
41negative regulation of cell killing (GO:0031342)3.59673492
42* regulation of mast cell degranulation (GO:0043304)3.56896157
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.50068277
44germinal center formation (GO:0002467)3.49773734
45response to host immune response (GO:0052572)3.48418695
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48418695
47response to muramyl dipeptide (GO:0032495)3.47169200
48negative regulation of B cell proliferation (GO:0030889)3.45576125
49positive regulation of antigen processing and presentation (GO:0002579)3.44543117
50leukocyte aggregation (GO:0070486)3.43289435
51NIK/NF-kappaB signaling (GO:0038061)3.42268300
52interferon-gamma-mediated signaling pathway (GO:0060333)3.38782530
53* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36737345
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.36343899
55response to protozoan (GO:0001562)3.34277417
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32912112
57production of molecular mediator involved in inflammatory response (GO:0002532)3.32892311
58negative thymic T cell selection (GO:0045060)3.31249731
59cellular extravasation (GO:0045123)3.30255120
60myeloid dendritic cell activation (GO:0001773)3.29904552
61B cell homeostasis (GO:0001782)3.29488002
62negative regulation of T cell mediated immunity (GO:0002710)3.29390472
63* regulation of mast cell activation (GO:0033003)3.27060053
64* regulation of leukocyte degranulation (GO:0043300)3.26897166
65* neutrophil activation involved in immune response (GO:0002283)3.26428231
66* regulation of mast cell activation involved in immune response (GO:0033006)3.26342846
67* macrophage activation (GO:0042116)3.25903265
68natural killer cell differentiation (GO:0001779)3.25320983
69natural killer cell mediated cytotoxicity (GO:0042267)3.24128796
70natural killer cell mediated immunity (GO:0002228)3.24128796
71negative regulation of leukocyte mediated immunity (GO:0002704)3.23630104
72response to host (GO:0075136)3.23575376
73response to host defenses (GO:0052200)3.23575376
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23575376
75positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23397767
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18434229
77* regulation of gamma-delta T cell differentiation (GO:0045586)3.17655219
78B cell mediated immunity (GO:0019724)3.15666946
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13637707
80positive thymic T cell selection (GO:0045059)3.13629879
81L-serine transport (GO:0015825)3.13406802
82myeloid dendritic cell differentiation (GO:0043011)3.12541021
83regulation of B cell proliferation (GO:0030888)3.11741943
84* positive regulation of mast cell activation (GO:0033005)3.11439868
85lymphocyte homeostasis (GO:0002260)3.10800589
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10070077
87negative T cell selection (GO:0043383)3.09497247
88positive regulation of interferon-beta production (GO:0032728)3.09323012
89tolerance induction (GO:0002507)3.08249632
90regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07873824
91T cell homeostasis (GO:0043029)3.07179027
92regulation of histone H3-K9 methylation (GO:0051570)3.05456886
93* myeloid cell activation involved in immune response (GO:0002275)3.05370220
94negative regulation of bone resorption (GO:0045779)2.99923384
95leukocyte degranulation (GO:0043299)2.99881921
96positive T cell selection (GO:0043368)2.99182811
97response to type I interferon (GO:0034340)2.95384059
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95351005
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.95313589
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90710425
101regulation of T-helper 2 cell differentiation (GO:0045628)2.90701315
102antigen processing and presentation via MHC class Ib (GO:0002475)2.89154069
103T-helper 1 type immune response (GO:0042088)2.88827740
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88768899
105type I interferon signaling pathway (GO:0060337)2.87777849
106cellular response to type I interferon (GO:0071357)2.87777849
107hepatocyte apoptotic process (GO:0097284)2.87086284
108* antigen receptor-mediated signaling pathway (GO:0050851)2.86850609
109negative regulation of T-helper cell differentiation (GO:0045623)2.85923468
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85923468
111T cell migration (GO:0072678)2.85858948
112I-kappaB phosphorylation (GO:0007252)2.85519703
113neutrophil mediated immunity (GO:0002446)2.85333224
114positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85306431
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84972546
116positive regulation of type 2 immune response (GO:0002830)2.83568444
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83508847
118mononuclear cell proliferation (GO:0032943)2.83272103
119regulation of antigen processing and presentation (GO:0002577)2.83161599
120regulation of B cell apoptotic process (GO:0002902)2.81306755
121positive regulation of cellular amide metabolic process (GO:0034250)2.81147821
122positive regulation of granulocyte differentiation (GO:0030854)2.79221937
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78328351
124lymphocyte proliferation (GO:0046651)2.77716160
125regulation of tolerance induction (GO:0002643)2.77189126
126negative regulation of innate immune response (GO:0045824)2.76989940
127negative regulation of interleukin-12 production (GO:0032695)2.76372604
128* myeloid leukocyte activation (GO:0002274)2.75677668
129negative regulation of interleukin-6 production (GO:0032715)2.75458297
130response to interleukin-15 (GO:0070672)2.74638024
131myeloid leukocyte mediated immunity (GO:0002444)2.74578985
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.74071309
133positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73506093
134* regulation of gamma-delta T cell activation (GO:0046643)2.72716478
135adaptation of signaling pathway (GO:0023058)2.72338088
136leukocyte homeostasis (GO:0001776)2.72130084
137pinocytosis (GO:0006907)2.71694531
138* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.70999600
139negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.70942204
140mature B cell differentiation involved in immune response (GO:0002313)2.70280491
141B cell activation (GO:0042113)2.69407500
142positive regulation of B cell proliferation (GO:0030890)2.67012183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.11117675
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.94627383
3E2F7_22180533_ChIP-Seq_HELA_Human4.26040263
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95855991
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.67583329
6* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.57310944
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55089947
8* MYC_22102868_ChIP-Seq_BL_Human3.53072285
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48897029
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.41255103
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38370786
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34699179
13* VDR_21846776_ChIP-Seq_THP-1_Human3.20385792
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.99749084
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.90854017
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58800360
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57610430
18SCL_19346495_ChIP-Seq_HPC-7_Human2.57236125
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.56946092
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51910331
21VDR_24763502_ChIP-Seq_THP-1_Human2.43533041
22* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.43136611
23RUNX_20019798_ChIP-Seq_JUKART_Human2.36272101
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32843692
25MAF_26560356_Chip-Seq_TH1_Human2.32202609
26MYB_26560356_Chip-Seq_TH2_Human2.27375369
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26040036
28* SPI1_23547873_ChIP-Seq_NB4_Human2.25819320
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24119874
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22229182
31MYB_26560356_Chip-Seq_TH1_Human2.14932665
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10956404
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10634709
34UTX_26944678_Chip-Seq_JUKART_Human2.08352648
35STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07907967
36TCF7_22412390_ChIP-Seq_EML_Mouse2.03621481
37SPI1_23127762_ChIP-Seq_K562_Human2.01205238
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99777685
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.97538761
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97386038
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96965755
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81745534
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80549399
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75582889
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71236700
46GATA1_22025678_ChIP-Seq_K562_Human1.70975568
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68257511
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68028147
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60886478
50KDM2B_26808549_Chip-Seq_DND41_Human1.55145048
51PU_27001747_Chip-Seq_BMDM_Mouse1.52866053
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51958605
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51635424
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48551406
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45620197
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41536036
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.40611622
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35113688
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34952891
60GATA3_27048872_Chip-Seq_THYMUS_Human1.33994275
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32731740
62MAF_26560356_Chip-Seq_TH2_Human1.31394244
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31180512
64VDR_24787735_ChIP-Seq_THP-1_Human1.27551657
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27545315
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26454834
67CIITA_25753668_ChIP-Seq_RAJI_Human1.24678520
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24499883
69* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24444068
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23791610
71* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22274759
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22039140
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20698010
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15706337
75BCL6_27268052_Chip-Seq_Bcells_Human1.10819245
76LXR_22292898_ChIP-Seq_THP-1_Human1.09701873
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.08262192
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03859673
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03583691
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02139182
81BCOR_27268052_Chip-Seq_Bcells_Human1.02113693
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98316205
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98044143
84GATA3_26560356_Chip-Seq_TH2_Human0.96083837
85* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95402634
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95383125
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95366130
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93849628
89NCOR1_26117541_ChIP-Seq_K562_Human0.92489206
90* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91854034
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89663617
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86818025
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86448714
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85716582
95GATA1_19941826_ChIP-Seq_K562_Human0.85145553
96TFEB_21752829_ChIP-Seq_HELA_Human0.84740325
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84646577
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84041118
99STAT1_20625510_ChIP-Seq_HELA_Human0.81328001
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80106953
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79977565
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79462869
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79270658
104ELF1_20517297_ChIP-Seq_JURKAT_Human0.79042838
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.77711209
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.77636670
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.77338527
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.76265800
109SPI1_20517297_ChIP-Seq_HL60_Human0.75659519
110ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75325179
111GATA2_19941826_ChIP-Seq_K562_Human0.75060434
112P300_27268052_Chip-Seq_Bcells_Human0.74663343
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.71355433
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70297048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.75757670
2MP0003303_peritoneal_inflammation4.02989818
3MP0001800_abnormal_humoral_immune3.80562822
4MP0001790_abnormal_immune_system3.79445189
5MP0005387_immune_system_phenotype3.79445189
6MP0000685_abnormal_immune_system3.40514528
7MP0002452_abnormal_antigen_presenting3.28088401
8MP0003436_decreased_susceptibility_to3.09677659
9MP0005000_abnormal_immune_tolerance3.08293282
10MP0002723_abnormal_immune_serum2.81547167
11MP0009785_altered_susceptibility_to2.72451636
12MP0002420_abnormal_adaptive_immunity2.70302654
13MP0001819_abnormal_immune_cell2.67423803
14MP0002419_abnormal_innate_immunity2.64587966
15MP0005025_abnormal_response_to2.54180220
16MP0005671_abnormal_response_to2.51912413
17MP0002398_abnormal_bone_marrow2.43528034
18MP0002148_abnormal_hypersensitivity_rea2.40006019
19MP0000716_abnormal_immune_system2.27246417
20MP0000689_abnormal_spleen_morphology2.21157189
21MP0009278_abnormal_bone_marrow2.19903573
22MP0002166_altered_tumor_susceptibility2.10765775
23MP0002396_abnormal_hematopoietic_system2.04028266
24MP0004510_myositis2.03068909
25MP0005464_abnormal_platelet_physiology1.98054515
26MP0003300_gastrointestinal_ulcer1.96597832
27MP0002722_abnormal_immune_system1.93057657
28MP0002429_abnormal_blood_cell1.88530762
29MP0002405_respiratory_system_inflammati1.87335554
30MP0004947_skin_inflammation1.86112292
31MP0000569_abnormal_digit_pigmentation1.85862200
32MP0004808_abnormal_hematopoietic_stem1.83438595
33MP0005058_abnormal_lysosome_morphology1.81970277
34MP0001845_abnormal_inflammatory_respons1.75740230
35MP0006082_CNS_inflammation1.74855601
36MP0010155_abnormal_intestine_physiology1.73627724
37MP0002006_tumorigenesis1.73025970
38MP0001853_heart_inflammation1.66881751
39MP0006054_spinal_hemorrhage1.58393354
40MP0003183_abnormal_peptide_metabolism1.54456973
41MP0005451_abnormal_body_composition1.52493347
42MP0003172_abnormal_lysosome_physiology1.51515175
43MP0005397_hematopoietic_system_phenotyp1.48202527
44MP0001545_abnormal_hematopoietic_system1.48202527
45MP0002132_abnormal_respiratory_system1.47949378
46MP0001533_abnormal_skeleton_physiology1.43403945
47MP0000703_abnormal_thymus_morphology1.40285970
48MP0000465_gastrointestinal_hemorrhage1.37807007
49MP0005174_abnormal_tail_pigmentation1.30813691
50MP0003763_abnormal_thymus_physiology1.28827000
51MP0001873_stomach_inflammation1.28092663
52MP0003191_abnormal_cellular_cholesterol1.26392530
53MP0005310_abnormal_salivary_gland1.25885215
54MP0008469_abnormal_protein_level1.25872339
55MP0005076_abnormal_cell_differentiation1.25386725
56MP0005075_abnormal_melanosome_morpholog1.23844974
57MP0009333_abnormal_splenocyte_physiolog1.21147745
58MP0002933_joint_inflammation1.21139910
59MP0003724_increased_susceptibility_to1.20450731
60MP0004381_abnormal_hair_follicle1.15127534
61MP0003448_altered_tumor_morphology1.14276443
62MP0010307_abnormal_tumor_latency1.13568849
63MP0001879_abnormal_lymphatic_vessel1.10574589
64MP0003566_abnormal_cell_adhesion1.10498869
65MP0010352_gastrointestinal_tract_polyps1.10285282
66MP0004883_abnormal_blood_vessel1.09881760
67MP0008004_abnormal_stomach_pH1.06518604
68MP0002019_abnormal_tumor_incidence1.03020405
69MP0003866_abnormal_defecation1.00790735
70MP0000490_abnormal_crypts_of0.97237269
71MP0003690_abnormal_glial_cell0.95209510
72MP0003806_abnormal_nucleotide_metabolis0.95065023
73MP0002998_abnormal_bone_remodeling0.93784038
74MP0009840_abnormal_foam_cell0.90263096
75MP0001986_abnormal_taste_sensitivity0.90186907
76MP0009764_decreased_sensitivity_to0.89881846
77MP0003828_pulmonary_edema0.89396426
78MP0008057_abnormal_DNA_replication0.89043652
79MP0000015_abnormal_ear_pigmentation0.88122089
80MP0002009_preneoplasia0.86576843
81MP0000858_altered_metastatic_potential0.84827759
82MP0003091_abnormal_cell_migration0.84163290
83MP0000343_altered_response_to0.82138197
84MP0005166_decreased_susceptibility_to0.81393605
85MP0003075_altered_response_to0.79694660
86MP0002136_abnormal_kidney_physiology0.79324548
87MP0005164_abnormal_response_to0.77239596
88MP0001851_eye_inflammation0.77153256
89MP0000249_abnormal_blood_vessel0.74771643
90MP0003453_abnormal_keratinocyte_physiol0.74039950
91MP0010094_abnormal_chromosome_stability0.72493299
92MP0009763_increased_sensitivity_to0.71376178
93MP0002138_abnormal_hepatobiliary_system0.70868620
94MP0003077_abnormal_cell_cycle0.69963064
95MP0000604_amyloidosis0.69334986
96MP0003656_abnormal_erythrocyte_physiolo0.69209401
97MP0009765_abnormal_xenobiotic_induced0.66171688
98MP0002095_abnormal_skin_pigmentation0.66103015
99MP0000767_abnormal_smooth_muscle0.64808120
100MP0005621_abnormal_cell_physiology0.64115776
101MP0000371_diluted_coat_color0.62405517
102MP0001663_abnormal_digestive_system0.62378513
103MP0003279_aneurysm0.61687554
104MP0002277_abnormal_respiratory_mucosa0.61474495
105MP0001915_intracranial_hemorrhage0.60242732
106MP0003795_abnormal_bone_structure0.59815363
107MP0008260_abnormal_autophagy0.59473158
108MP0002928_abnormal_bile_duct0.56882571
109MP0003045_fibrosis0.56304647
110MP0000313_abnormal_cell_death0.55817444
111MP0008874_decreased_physiological_sensi0.54430032
112MP0005390_skeleton_phenotype0.54095849
113MP0005023_abnormal_wound_healing0.54008917
114MP0005319_abnormal_enzyme/_coenzyme0.53890986
115MP0001958_emphysema0.53733426
116MP0000609_abnormal_liver_physiology0.51745862
117MP0009115_abnormal_fat_cell0.51537869
118MP0009931_abnormal_skin_appearance0.51204214
119MP0005381_digestive/alimentary_phenotyp0.47498985
120MP0004130_abnormal_muscle_cell0.44642097

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.72090193
2Cellulitis (HP:0100658)6.23011781
3Recurrent abscess formation (HP:0002722)5.53348553
4Recurrent bacterial skin infections (HP:0005406)5.22191321
5Recurrent viral infections (HP:0004429)5.10156844
6Papilloma (HP:0012740)4.93212078
7Verrucae (HP:0200043)4.93212078
8Colitis (HP:0002583)4.78468918
9Eczematoid dermatitis (HP:0000976)4.50882475
10Abnormality of B cell number (HP:0010975)4.48129434
11B lymphocytopenia (HP:0010976)4.48129434
12Recurrent bronchitis (HP:0002837)4.46006653
13Meningitis (HP:0001287)4.45107885
14Gastrointestinal stroma tumor (HP:0100723)4.30992419
15Recurrent fungal infections (HP:0002841)4.25031485
16Osteomyelitis (HP:0002754)4.14415876
17Thyroiditis (HP:0100646)4.12547192
18Inflammation of the large intestine (HP:0002037)4.11581008
19Panhypogammaglobulinemia (HP:0003139)4.03864472
20Gastrointestinal inflammation (HP:0004386)3.96397000
21Mediastinal lymphadenopathy (HP:0100721)3.88626984
22Recurrent sinusitis (HP:0011108)3.75463174
23Recurrent gram-negative bacterial infections (HP:0005420)3.74218023
24Small epiphyses (HP:0010585)3.55162511
25Recurrent skin infections (HP:0001581)3.51695212
26Recurrent pneumonia (HP:0006532)3.48691883
27Encephalitis (HP:0002383)3.48470452
28IgM deficiency (HP:0002850)3.45210391
29Sepsis (HP:0100806)3.44032346
30Vasculitis (HP:0002633)3.36898479
31Abnormality of glycolipid metabolism (HP:0010969)3.29561747
32Abnormality of liposaccharide metabolism (HP:0010968)3.29561747
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.29561747
34Chronic otitis media (HP:0000389)3.27698678
35Chronic sinusitis (HP:0011109)3.22389227
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.18019891
37Gastrointestinal infarctions (HP:0005244)3.15056313
38Abnormality of macrophages (HP:0004311)3.13180250
39Recurrent lower respiratory tract infections (HP:0002783)3.09320386
40Lymphopenia (HP:0001888)3.06558241
41Obstructive lung disease (HP:0006536)3.04889116
42Chronic obstructive pulmonary disease (HP:0006510)3.04889116
43Chronic mucocutaneous candidiasis (HP:0002728)3.01145340
44Recurrent cutaneous fungal infections (HP:0011370)3.01145340
45Epistaxis (HP:0000421)2.99908910
46Autoimmune thrombocytopenia (HP:0001973)2.98651689
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.97811100
48Chest pain (HP:0100749)2.95341421
49Emphysema (HP:0002097)2.94099234
50Mitral stenosis (HP:0001718)2.92448054
51Keratoconjunctivitis sicca (HP:0001097)2.88760766
52Hemoptysis (HP:0002105)2.86207351
53Periodontitis (HP:0000704)2.71576519
54Restrictive lung disease (HP:0002091)2.69661821
55Gingivitis (HP:0000230)2.69318770
56T lymphocytopenia (HP:0005403)2.67669444
57Keratoconjunctivitis (HP:0001096)2.66531460
58Eosinophilia (HP:0001880)2.66410889
59Abnormality of T cell number (HP:0011839)2.62844385
60Pustule (HP:0200039)2.60712786
61Hematochezia (HP:0002573)2.60045862
62Abnormality of the fingertips (HP:0001211)2.58841310
63Purpura (HP:0000979)2.51650474
64Myositis (HP:0100614)2.51183096
65Severe combined immunodeficiency (HP:0004430)2.50473465
66Combined immunodeficiency (HP:0005387)2.49763191
67Vertebral arch anomaly (HP:0008438)2.48035145
68Interstitial pulmonary disease (HP:0006530)2.46942116
69Elevated erythrocyte sedimentation rate (HP:0003565)2.46519771
70Pulmonary embolism (HP:0002204)2.44577560
71Abnormality of the prostate (HP:0008775)2.44220714
72Spontaneous hematomas (HP:0007420)2.42743241
73Amyloidosis (HP:0011034)2.42129739
74Recurrent otitis media (HP:0000403)2.40650380
75Leukocytosis (HP:0001974)2.39725581
76Flattened epiphyses (HP:0003071)2.39281532
77Hypoplasia of the thymus (HP:0000778)2.38813072
78Dysostosis multiplex (HP:0000943)2.37859050
79Bronchitis (HP:0012387)2.37681273
80Loss of speech (HP:0002371)2.36105705
81IgG deficiency (HP:0004315)2.35467295
82Abnormality of T cells (HP:0002843)2.30919172
83Increased cerebral lipofuscin (HP:0011813)2.30437493
84Skin ulcer (HP:0200042)2.30374677
85Ulnar bowing (HP:0003031)2.30089736
86Granulocytopenia (HP:0001913)2.27626195
87Abnormality of the intervertebral disk (HP:0005108)2.24939591
88Stomatitis (HP:0010280)2.22614686
89Abnormality of the pleura (HP:0002103)2.20741256
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19661905
91IgA deficiency (HP:0002720)2.18451635
92Vacuolated lymphocytes (HP:0001922)2.18385602
93Hepatosplenomegaly (HP:0001433)2.17712721
94Abnormality of eosinophils (HP:0001879)2.16250463
95Episodic fever (HP:0001954)2.14539871
96Increased serum ferritin (HP:0003281)2.14224340
97Anorexia (HP:0002039)2.14129861
98Pulmonary infiltrates (HP:0002113)2.11480165
99Gangrene (HP:0100758)2.09558864
100Skin rash (HP:0000988)2.09445623
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09028643
102Leukopenia (HP:0001882)2.08534333
103Increased IgE level (HP:0003212)2.08226035
104Hypergammaglobulinemia (HP:0010702)2.07992524
105Urticaria (HP:0001025)2.05147108
106Autoimmune hemolytic anemia (HP:0001890)2.04995081
107Thrombocytosis (HP:0001894)2.04393878
108Lymphoma (HP:0002665)2.04221442
109Abnormality of the peritoneum (HP:0002585)2.03211123
110Systemic lupus erythematosus (HP:0002725)2.02456602
111Abnormality of iron homeostasis (HP:0011031)2.01589083
112Nasal polyposis (HP:0100582)2.01299916
113Increased IgM level (HP:0003496)1.98413184
114Abnormality of T cell physiology (HP:0011840)1.98398254
115Prolonged bleeding time (HP:0003010)1.97726126
116Amaurosis fugax (HP:0100576)1.96337556
117Orchitis (HP:0100796)1.92873823
118Arterial thrombosis (HP:0004420)1.92464881
119Viral hepatitis (HP:0006562)1.91591143
120Arthropathy (HP:0003040)1.91362275
121Disinhibition (HP:0000734)1.90021351
122Retrobulbar optic neuritis (HP:0100654)1.88332057
123Optic neuritis (HP:0100653)1.88332057
124Petechiae (HP:0000967)1.88303119
125Neutropenia (HP:0001875)1.88088630
126Myocardial infarction (HP:0001658)1.86382732
127Gingival bleeding (HP:0000225)1.84700186
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.84466207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.88665527
2MAP4K14.50683151
3RIPK43.64624634
4ERN13.40610368
5BLK3.29101883
6GRK63.15194733
7MAP3K142.54446066
8CSF1R2.41301599
9TYK22.40116453
10PRPF4B2.34481460
11BTK2.14948360
12TBK12.12622332
13STK101.98141965
14IRAK41.91801084
15* SYK1.83946230
16SIK21.78311053
17BMPR21.64568416
18KIT1.63352284
19IRAK31.62922996
20JAK11.62393688
21CDK121.61125260
22EEF2K1.59622446
23MAP3K131.58601090
24CSK1.55550723
25IKBKB1.50943438
26LRRK21.50583236
27HCK1.48760311
28FES1.47737134
29TRIB31.46804081
30STK41.46586963
31PIM11.44383298
32MAP3K31.37593713
33IKBKE1.33414171
34* LYN1.32495933
35TGFBR21.32017934
36JAK31.29855032
37MAP3K111.28363765
38CLK11.24252633
39ZAP701.21171352
40PIK3CG1.17861296
41MATK1.15122931
42PKN21.13666941
43MARK31.12967655
44MAP3K11.11989593
45CDK41.07272084
46TESK21.07214748
47TAOK11.06460713
48TLK10.94860073
49* LCK0.91372244
50IRAK10.91221484
51NEK20.90956048
52TEC0.88662806
53CHUK0.86398380
54SMG10.86258254
55IRAK20.83021196
56MAP2K30.82945664
57TAOK30.82517617
58FGFR30.80850214
59PDPK10.80777341
60FGR0.77828189
61EPHB10.77644978
62ITK0.77385982
63CDK90.76913360
64RPS6KA40.76789827
65CAMK1D0.74954838
66DYRK1B0.71238552
67GRK70.71175256
68MAPK40.70983855
69TTN0.69979628
70PTK60.69293918
71SIK30.67925250
72JAK20.67395845
73CDK60.64937590
74KSR20.64774090
75MARK20.61407401
76MAPK70.59759939
77MAP3K20.59669265
78TAOK20.59603467
79BRD40.58019261
80CAMK1G0.57971228
81HIPK20.55618210
82ABL10.55321343
83CDC42BPA0.54691507
84TNK20.52838192
85RPS6KL10.52005938
86EIF2AK30.50662609
87MAP3K80.50162848
88MAP3K60.49598525
89ACVR1B0.49058797
90ALK0.48583313
91STK30.47033143
92CDK190.46132965
93SIK10.45881174
94MST40.45034906
95MAP3K50.45023595
96PRKCQ0.44994702
97TRPM70.43952422
98MAPK120.43802205
99STK240.43729017
100WNK10.42217219
101MAP2K20.42113343
102MELK0.41693190
103PDK10.40766174
104BMX0.40577000
105PRKCD0.40256055
106MAPK110.38999407
107SCYL20.38001689
108YES10.37448052
109RPS6KB20.35572626
110MAP2K60.34636051
111MAPKAPK20.34252548
112FGFR40.32115088
113NME20.31351850
114MAP3K70.30261333
115* EGFR0.29874261
116* FYN0.29566125
117TXK0.28390757
118RPS6KA60.28145557
119MAP2K10.28133186
120SGK30.27739588
121CAMKK20.26835151
122RET0.26762732
123STK110.26230239
124NEK90.26001236
125MAPK30.25623382
126PRKD20.25443969
127RAF10.25438068
128RPS6KA50.24914160
129PKN10.24215474
130RPS6KC10.20198934

Predicted pathways (KEGG)

RankGene SetZ-score
1* B cell receptor signaling pathway_Homo sapiens_hsa046624.22106543
2Primary immunodeficiency_Homo sapiens_hsa053403.81533995
3Autoimmune thyroid disease_Homo sapiens_hsa053202.97987493
4Leishmaniasis_Homo sapiens_hsa051402.93991751
5* NF-kappa B signaling pathway_Homo sapiens_hsa040642.61751900
6* Osteoclast differentiation_Homo sapiens_hsa043802.54212254
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19814013
8Hematopoietic cell lineage_Homo sapiens_hsa046402.19413425
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.11294193
10* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.09550381
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95415800
12Measles_Homo sapiens_hsa051621.89142782
13Staphylococcus aureus infection_Homo sapiens_hsa051501.87499696
14* Tuberculosis_Homo sapiens_hsa051521.86565741
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78044284
16Antigen processing and presentation_Homo sapiens_hsa046121.76223942
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69080015
18Non-homologous end-joining_Homo sapiens_hsa034501.67385090
19Pertussis_Homo sapiens_hsa051331.65549147
20Influenza A_Homo sapiens_hsa051641.56848230
21Herpes simplex infection_Homo sapiens_hsa051681.56402348
22Legionellosis_Homo sapiens_hsa051341.55806042
23* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55746648
24Chemokine signaling pathway_Homo sapiens_hsa040621.54695528
25Malaria_Homo sapiens_hsa051441.54410773
26Toxoplasmosis_Homo sapiens_hsa051451.51591885
27* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43943659
28Chronic myeloid leukemia_Homo sapiens_hsa052201.41224296
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40537871
30Apoptosis_Homo sapiens_hsa042101.40204629
31Systemic lupus erythematosus_Homo sapiens_hsa053221.39439590
32TNF signaling pathway_Homo sapiens_hsa046681.37329167
33Shigellosis_Homo sapiens_hsa051311.34525838
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32216341
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.31907330
36Hepatitis B_Homo sapiens_hsa051611.31754403
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31749906
38T cell receptor signaling pathway_Homo sapiens_hsa046601.22358764
39Acute myeloid leukemia_Homo sapiens_hsa052211.20501276
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19015033
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.18622313
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.15996319
43Lysosome_Homo sapiens_hsa041421.14714086
44Other glycan degradation_Homo sapiens_hsa005111.14275626
45Non-small cell lung cancer_Homo sapiens_hsa052231.12518894
46Salmonella infection_Homo sapiens_hsa051321.12435129
47Pancreatic cancer_Homo sapiens_hsa052121.12082674
48Graft-versus-host disease_Homo sapiens_hsa053321.09134818
49African trypanosomiasis_Homo sapiens_hsa051431.06748453
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.04238480
51* Viral carcinogenesis_Homo sapiens_hsa052031.04162297
52* Epstein-Barr virus infection_Homo sapiens_hsa051691.03727553
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02439449
54Allograft rejection_Homo sapiens_hsa053300.99606118
55* Platelet activation_Homo sapiens_hsa046110.98389003
56Hepatitis C_Homo sapiens_hsa051600.93868455
57Base excision repair_Homo sapiens_hsa034100.92811112
58Small cell lung cancer_Homo sapiens_hsa052220.91283622
59Asthma_Homo sapiens_hsa053100.84930779
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84902538
61Viral myocarditis_Homo sapiens_hsa054160.84769480
62Phagosome_Homo sapiens_hsa041450.79400312
63Rheumatoid arthritis_Homo sapiens_hsa053230.78335760
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75919440
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72452903
66HTLV-I infection_Homo sapiens_hsa051660.71065925
67MicroRNAs in cancer_Homo sapiens_hsa052060.69778213
68VEGF signaling pathway_Homo sapiens_hsa043700.67936126
69Insulin resistance_Homo sapiens_hsa049310.67793821
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64912493
71FoxO signaling pathway_Homo sapiens_hsa040680.64604241
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63416260
73Type II diabetes mellitus_Homo sapiens_hsa049300.60315102
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60104614
75Glioma_Homo sapiens_hsa052140.57910976
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57296721
77mTOR signaling pathway_Homo sapiens_hsa041500.56866483
78Caffeine metabolism_Homo sapiens_hsa002320.55069245
79HIF-1 signaling pathway_Homo sapiens_hsa040660.53569534
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.53519811
81Prolactin signaling pathway_Homo sapiens_hsa049170.51713828
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50793128
83Amoebiasis_Homo sapiens_hsa051460.48848018
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48351118
85Endocytosis_Homo sapiens_hsa041440.48013138
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46484815
87Notch signaling pathway_Homo sapiens_hsa043300.46069834
88Inositol phosphate metabolism_Homo sapiens_hsa005620.45985140
89Colorectal cancer_Homo sapiens_hsa052100.45578185
90DNA replication_Homo sapiens_hsa030300.45133849
91Proteoglycans in cancer_Homo sapiens_hsa052050.44356380
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44158472
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43875735
94Prostate cancer_Homo sapiens_hsa052150.43738633
95Lysine degradation_Homo sapiens_hsa003100.43389008
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.42448790
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42309488
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40786637
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39888925
100Alcoholism_Homo sapiens_hsa050340.39881303
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39625722
102MAPK signaling pathway_Homo sapiens_hsa040100.38103546
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36920912
104Renal cell carcinoma_Homo sapiens_hsa052110.36732159
105GnRH signaling pathway_Homo sapiens_hsa049120.36542640
106Type I diabetes mellitus_Homo sapiens_hsa049400.34940922
107Dorso-ventral axis formation_Homo sapiens_hsa043200.34729942
108* Phospholipase D signaling pathway_Homo sapiens_hsa040720.34469292
109p53 signaling pathway_Homo sapiens_hsa041150.34346729
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33631404
111Choline metabolism in cancer_Homo sapiens_hsa052310.30027026
112Mismatch repair_Homo sapiens_hsa034300.29379964
113Renin-angiotensin system_Homo sapiens_hsa046140.27156220
114Collecting duct acid secretion_Homo sapiens_hsa049660.27048519
115Endometrial cancer_Homo sapiens_hsa052130.26750516
116Pentose phosphate pathway_Homo sapiens_hsa000300.21371372
117Arachidonic acid metabolism_Homo sapiens_hsa005900.20166371
118Regulation of autophagy_Homo sapiens_hsa041400.19896323

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