SYN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19943385
2synaptic vesicle exocytosis (GO:0016079)5.62431596
3vocalization behavior (GO:0071625)5.60609621
4locomotory exploration behavior (GO:0035641)5.47726972
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45192973
6synaptic vesicle maturation (GO:0016188)5.43434987
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41759476
8L-amino acid import (GO:0043092)5.30506872
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.26119935
10glutamate secretion (GO:0014047)5.19960429
11regulation of glutamate receptor signaling pathway (GO:1900449)4.97358760
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.94890655
13regulation of synaptic vesicle exocytosis (GO:2000300)4.94384910
14protein localization to synapse (GO:0035418)4.91473003
15cerebellar granule cell differentiation (GO:0021707)4.80217935
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.71237256
17neuronal action potential propagation (GO:0019227)4.71104222
18neuron cell-cell adhesion (GO:0007158)4.67813128
19amino acid import (GO:0043090)4.66417509
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.57613965
21exploration behavior (GO:0035640)4.55782182
22regulation of neuronal synaptic plasticity (GO:0048168)4.52012799
23regulation of synaptic vesicle transport (GO:1902803)4.48606475
24glutamate receptor signaling pathway (GO:0007215)4.47929268
25* neurotransmitter secretion (GO:0007269)4.45040400
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.41925376
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.40243556
28negative regulation of dendrite morphogenesis (GO:0050774)4.29276308
29potassium ion homeostasis (GO:0055075)4.28180880
30synaptic transmission, glutamatergic (GO:0035249)4.22070615
31proline transport (GO:0015824)4.16394439
32potassium ion import (GO:0010107)4.14054037
33regulation of voltage-gated calcium channel activity (GO:1901385)4.08975709
34neuron-neuron synaptic transmission (GO:0007270)4.06430561
35central nervous system myelination (GO:0022010)4.02915452
36axon ensheathment in central nervous system (GO:0032291)4.02915452
37gamma-aminobutyric acid transport (GO:0015812)4.01007665
38layer formation in cerebral cortex (GO:0021819)3.95983048
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95875926
40long-term memory (GO:0007616)3.95489882
41dendritic spine morphogenesis (GO:0060997)3.87724380
42neuron recognition (GO:0008038)3.85883050
43regulation of ARF protein signal transduction (GO:0032012)3.84163294
44cellular sodium ion homeostasis (GO:0006883)3.80699932
45regulation of synapse structural plasticity (GO:0051823)3.80656970
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.80292271
47regulation of synapse maturation (GO:0090128)3.78992549
48cellular potassium ion homeostasis (GO:0030007)3.78658648
49regulation of postsynaptic membrane potential (GO:0060078)3.74980660
50* neurotransmitter transport (GO:0006836)3.74663716
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73525723
52positive regulation of membrane potential (GO:0045838)3.72871972
53neurotransmitter-gated ion channel clustering (GO:0072578)3.71679866
54regulation of synaptic plasticity (GO:0048167)3.68520474
55synaptic vesicle endocytosis (GO:0048488)3.68441462
56positive regulation of synapse maturation (GO:0090129)3.62616142
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60239452
58regulation of vesicle fusion (GO:0031338)3.60106772
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57131589
60long-term synaptic potentiation (GO:0060291)3.56622020
61regulation of dendritic spine morphogenesis (GO:0061001)3.54501641
62transmission of nerve impulse (GO:0019226)3.53807384
63neurotransmitter uptake (GO:0001504)3.53616574
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.53545751
65regulation of neurotransmitter secretion (GO:0046928)3.52263514
66acidic amino acid transport (GO:0015800)3.42923309
67* regulation of neurotransmitter levels (GO:0001505)3.41781176
68axonal fasciculation (GO:0007413)3.39788769
69activation of protein kinase A activity (GO:0034199)3.36654804
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.35961626
71fear response (GO:0042596)3.27548797
72neuromuscular synaptic transmission (GO:0007274)3.27210265
73sodium ion export (GO:0071436)3.27161963
74vesicle docking involved in exocytosis (GO:0006904)3.26231829
75behavioral fear response (GO:0001662)3.25643303
76behavioral defense response (GO:0002209)3.25643303
77regulation of neurotransmitter transport (GO:0051588)3.24696632
78synaptic vesicle transport (GO:0048489)3.24135123
79establishment of synaptic vesicle localization (GO:0097480)3.24135123
80detection of calcium ion (GO:0005513)3.22560059
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22141766
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21202814
83positive regulation of neurotransmitter secretion (GO:0001956)3.20782780
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20560910
85response to histamine (GO:0034776)3.19534005
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18672728
87neuromuscular process controlling posture (GO:0050884)3.18596959
88membrane depolarization (GO:0051899)3.18395519
89positive regulation of neurotransmitter transport (GO:0051590)3.18007209
90cell communication involved in cardiac conduction (GO:0086065)3.15317115
91learning (GO:0007612)3.14437451
92postsynaptic membrane organization (GO:0001941)3.14054499
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13977702
94cytoskeletal anchoring at plasma membrane (GO:0007016)3.12228045
95cerebellar Purkinje cell differentiation (GO:0021702)3.11041222
96regulation of synaptic transmission (GO:0050804)3.10556871
97regulation of exocytosis (GO:0017157)3.10470385
98neuromuscular process (GO:0050905)3.09773774
99auditory behavior (GO:0031223)3.08595345
100cell differentiation in hindbrain (GO:0021533)3.08360294
101positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07549759
102regulation of glutamate secretion (GO:0014048)3.06685951
103neuromuscular process controlling balance (GO:0050885)3.06481979
104vesicle docking (GO:0048278)3.06235367
105regulation of dendritic spine development (GO:0060998)3.06178600
106* synaptic transmission (GO:0007268)3.05883871
107positive regulation of dendritic spine development (GO:0060999)3.05859166
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04701624
109L-glutamate transport (GO:0015813)3.03876273
110vesicle transport along microtubule (GO:0047496)3.03521861
111positive regulation of synaptic transmission (GO:0050806)3.01900721
112intraspecies interaction between organisms (GO:0051703)3.01624619
113social behavior (GO:0035176)3.01624619
114presynaptic membrane assembly (GO:0097105)3.01417959
115innervation (GO:0060384)3.00714272
116cell communication by electrical coupling (GO:0010644)3.00264467
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.99899968
118membrane depolarization during action potential (GO:0086010)2.99719865
119mating behavior (GO:0007617)2.99018419
120dendritic spine organization (GO:0097061)2.97361767
121synapse assembly (GO:0007416)2.94641721
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94229153
123glycine transport (GO:0015816)2.93678967
124behavioral response to cocaine (GO:0048148)2.93372964
125membrane hyperpolarization (GO:0060081)2.90132266
126neuronal ion channel clustering (GO:0045161)2.89397987
127long term synaptic depression (GO:0060292)2.88578957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.60134045
2GBX2_23144817_ChIP-Seq_PC3_Human3.60805740
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26123351
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21495792
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16868586
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.80797067
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80320845
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80320845
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77599089
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74206884
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60223900
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59769531
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56697088
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56118472
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.53975798
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.52868105
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39878969
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.37006500
19DROSHA_22980978_ChIP-Seq_HELA_Human2.30991321
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.26514216
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26022490
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25141430
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.23460061
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.17310601
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.01336406
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99702680
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98932879
28TAF15_26573619_Chip-Seq_HEK293_Human1.94293812
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92903899
30AR_21572438_ChIP-Seq_LNCaP_Human1.88646304
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83134104
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83027794
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80851542
34SMAD4_21799915_ChIP-Seq_A2780_Human1.72384720
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.60681851
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60032517
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57179042
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57007794
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50480102
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50101805
41P300_19829295_ChIP-Seq_ESCs_Human1.49637274
42ZNF274_21170338_ChIP-Seq_K562_Hela1.45871968
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41732205
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39307949
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34196794
46AR_25329375_ChIP-Seq_VCAP_Human1.34139116
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33086053
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.32096310
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31338044
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.30609522
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29985623
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29136096
53TET1_21490601_ChIP-Seq_MESCs_Mouse1.29119151
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28790794
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27808500
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27519746
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.24355047
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23364880
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.22129950
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.22052477
61* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21854534
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.20456038
63* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19894050
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18271816
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16414020
66CTCF_27219007_Chip-Seq_Bcells_Human1.15932221
67* STAT3_23295773_ChIP-Seq_U87_Human1.15617995
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15508637
69IGF1R_20145208_ChIP-Seq_DFB_Human1.14347105
70FUS_26573619_Chip-Seq_HEK293_Human1.13818972
71* AR_19668381_ChIP-Seq_PC3_Human1.13250406
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10971395
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10559312
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07462165
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07344884
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.05559734
77TCF4_23295773_ChIP-Seq_U87_Human1.05091541
78RNF2_27304074_Chip-Seq_NSC_Mouse1.03794667
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.03582625
80VDR_22108803_ChIP-Seq_LS180_Human1.03248285
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03233746
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03033073
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02568000
84* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02109425
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01605857
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01586174
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00487409
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00353695
89RUNX2_22187159_ChIP-Seq_PCA_Human1.00270403
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00180276
91JUN_21703547_ChIP-Seq_K562_Human0.99268502
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.98727749
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98487781
94TP53_16413492_ChIP-PET_HCT116_Human0.96107645
95DPY_21335234_ChIP-Seq_ESCs_Mouse0.95316560
96BCAT_22108803_ChIP-Seq_LS180_Human0.94997177
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94237416
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.92723453
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91640189
100AHR_22903824_ChIP-Seq_MCF-7_Human0.91476973
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.90993418
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90753847
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90523899
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90296427
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90065176
106OCT4_19829295_ChIP-Seq_ESCs_Human0.89449672
107TP53_18474530_ChIP-ChIP_U2OS_Human0.89404641
108* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88671767
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.88501744
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.87840454
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87483424
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86279088
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85772227
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85114392
115ER_23166858_ChIP-Seq_MCF-7_Human0.84336087
116KDM2B_26808549_Chip-Seq_K562_Human0.83885472
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.83870074
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83860597
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83703130
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83695987
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83658362
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83589340
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.81563173
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80958432
125* LXR_22292898_ChIP-Seq_THP-1_Human0.80952453
126KLF4_19829295_ChIP-Seq_ESCs_Human0.79878661
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77866481
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77437424
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75931566
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75910146
131SMC4_20622854_ChIP-Seq_HELA_Human0.75376715
132EGR1_19032775_ChIP-ChIP_M12_Human0.75293892
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74821679
134SOX9_26525672_Chip-Seq_HEART_Mouse0.74756468
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74127553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.49515561
2MP0003880_abnormal_central_pattern4.97965373
3* MP0003635_abnormal_synaptic_transmissio4.21978457
4MP0004270_analgesia3.69782596
5MP0009745_abnormal_behavioral_response3.64284498
6MP0002822_catalepsy3.46277529
7MP0002063_abnormal_learning/memory/cond3.39643543
8* MP0002064_seizures3.24832859
9MP0009046_muscle_twitch3.01472267
10MP0001968_abnormal_touch/_nociception3.00573680
11MP0002572_abnormal_emotion/affect_behav2.90174694
12MP0002272_abnormal_nervous_system2.68197183
13MP0001501_abnormal_sleep_pattern2.66981427
14MP0002734_abnormal_mechanical_nocicepti2.62574313
15MP0001440_abnormal_grooming_behavior2.49427540
16MP0005423_abnormal_somatic_nervous2.46356226
17MP0001486_abnormal_startle_reflex2.42177151
18MP0002736_abnormal_nociception_after2.42091609
19MP0002735_abnormal_chemical_nociception2.32793323
20MP0002733_abnormal_thermal_nociception2.09794838
21MP0003329_amyloid_beta_deposits2.08748103
22MP0001970_abnormal_pain_threshold2.03432410
23MP0002067_abnormal_sensory_capabilities1.95890403
24MP0006276_abnormal_autonomic_nervous1.93039961
25MP0004858_abnormal_nervous_system1.90081507
26MP0009780_abnormal_chondrocyte_physiolo1.83928660
27MP0008569_lethality_at_weaning1.82985042
28MP0002184_abnormal_innervation1.82019533
29MP0005386_behavior/neurological_phenoty1.77845659
30MP0004924_abnormal_behavior1.77845659
31MP0002557_abnormal_social/conspecific_i1.70759170
32MP0000778_abnormal_nervous_system1.70264207
33MP0002909_abnormal_adrenal_gland1.65428477
34MP0004811_abnormal_neuron_physiology1.64263404
35MP0001529_abnormal_vocalization1.52667631
36MP0005646_abnormal_pituitary_gland1.51507371
37MP0010386_abnormal_urinary_bladder1.49563050
38MP0001905_abnormal_dopamine_level1.49478085
39MP0000955_abnormal_spinal_cord1.48282853
40MP0003879_abnormal_hair_cell1.46449133
41MP0001984_abnormal_olfaction1.45973193
42MP0002066_abnormal_motor_capabilities/c1.40724687
43MP0005645_abnormal_hypothalamus_physiol1.38679211
44MP0003787_abnormal_imprinting1.37640725
45MP0002837_dystrophic_cardiac_calcinosis1.37413919
46MP0003633_abnormal_nervous_system1.33553289
47* MP0002882_abnormal_neuron_morphology1.32662092
48MP0004885_abnormal_endolymph1.28333859
49MP0004142_abnormal_muscle_tone1.24533938
50MP0003122_maternal_imprinting1.23263108
51MP0001502_abnormal_circadian_rhythm1.20236751
52MP0003631_nervous_system_phenotype1.15054550
53MP0008872_abnormal_physiological_respon1.14611638
54MP0001188_hyperpigmentation1.08388485
55MP0002638_abnormal_pupillary_reflex1.04897060
56* MP0002152_abnormal_brain_morphology1.03348356
57MP0000751_myopathy1.00903858
58MP0004147_increased_porphyrin_level1.00509870
59MP0000013_abnormal_adipose_tissue0.99696809
60MP0000604_amyloidosis0.98499965
61MP0005535_abnormal_body_temperature0.95081309
62MP0002069_abnormal_eating/drinking_beha0.95044887
63MP0008874_decreased_physiological_sensi0.94737479
64MP0001346_abnormal_lacrimal_gland0.94500621
65MP0004145_abnormal_muscle_electrophysio0.93058918
66MP0002229_neurodegeneration0.90677199
67MP0008877_abnormal_DNA_methylation0.88738681
68MP0001348_abnormal_lacrimal_gland0.87651216
69MP0004484_altered_response_of0.84166915
70MP0002876_abnormal_thyroid_physiology0.83117762
71MP0004085_abnormal_heartbeat0.82526728
72MP0004742_abnormal_vestibular_system0.81325963
73MP0001963_abnormal_hearing_physiology0.81148169
74MP0001177_atelectasis0.80876483
75MP0003632_abnormal_nervous_system0.80522986
76MP0005551_abnormal_eye_electrophysiolog0.79973914
77MP0003075_altered_response_to0.79213436
78MP0003634_abnormal_glial_cell0.76286273
79MP0001986_abnormal_taste_sensitivity0.75189202
80MP0004215_abnormal_myocardial_fiber0.74252281
81MP0005499_abnormal_olfactory_system0.73000017
82MP0005394_taste/olfaction_phenotype0.73000017
83MP0004510_myositis0.71143472
84MP0002752_abnormal_somatic_nervous0.70640596
85MP0003690_abnormal_glial_cell0.67371890
86MP0001664_abnormal_digestion0.66057266
87MP0000920_abnormal_myelination0.65596555
88MP0010234_abnormal_vibrissa_follicle0.65468695
89MP0002090_abnormal_vision0.65193191
90MP0004130_abnormal_muscle_cell0.63497314
91MP0008961_abnormal_basal_metabolism0.63141392
92MP0000631_abnormal_neuroendocrine_gland0.61707699
93MP0005167_abnormal_blood-brain_barrier0.59918860
94MP0005409_darkened_coat_color0.57761563
95MP0001485_abnormal_pinna_reflex0.56987805
96MP0005623_abnormal_meninges_morphology0.56324109
97MP0010768_mortality/aging0.53510590
98MP0001943_abnormal_respiration0.53048643
99MP0003172_abnormal_lysosome_physiology0.52838370
100MP0000579_abnormal_nail_morphology0.52392923
101MP0003283_abnormal_digestive_organ0.52211137
102MP0002082_postnatal_lethality0.52193909
103MP0004233_abnormal_muscle_weight0.51704289
104MP0005187_abnormal_penis_morphology0.51428793
105MP0003137_abnormal_impulse_conducting0.51356434
106MP0003123_paternal_imprinting0.50160956
107MP0004043_abnormal_pH_regulation0.49447393
108MP0010769_abnormal_survival0.48355917
109MP0003956_abnormal_body_size0.48025777
110MP0003121_genomic_imprinting0.47673327
111MP0000569_abnormal_digit_pigmentation0.47225594
112MP0010770_preweaning_lethality0.46998851
113MP0000026_abnormal_inner_ear0.45676444
114* MP0003861_abnormal_nervous_system0.44625336
115MP0002873_normal_phenotype0.43894630
116MP0005166_decreased_susceptibility_to0.43160284
117MP0002169_no_abnormal_phenotype0.42212950
118MP0001299_abnormal_eye_distance/0.41267505

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.48834047
2Myokymia (HP:0002411)6.84738552
3Focal seizures (HP:0007359)6.09464249
4Visual hallucinations (HP:0002367)5.93619273
5Atonic seizures (HP:0010819)5.20703245
6Epileptic encephalopathy (HP:0200134)4.95591197
7Absence seizures (HP:0002121)4.69075708
8Febrile seizures (HP:0002373)4.68758291
9Progressive cerebellar ataxia (HP:0002073)4.37044809
10Dialeptic seizures (HP:0011146)4.29922869
11Generalized tonic-clonic seizures (HP:0002069)4.25263093
12Hyperventilation (HP:0002883)3.77695831
13Supranuclear gaze palsy (HP:0000605)3.76737265
14Action tremor (HP:0002345)3.74602016
15Amblyopia (HP:0000646)3.66604432
16Cerebral hypomyelination (HP:0006808)3.54639708
17Obstructive sleep apnea (HP:0002870)3.51428512
18Broad-based gait (HP:0002136)3.50185097
19Tetraplegia (HP:0002445)3.37050596
20Cerebral inclusion bodies (HP:0100314)3.36514332
21Poor eye contact (HP:0000817)3.33918517
22Anxiety (HP:0000739)3.24082515
23Impaired vibration sensation in the lower limbs (HP:0002166)3.23292562
24Depression (HP:0000716)3.22488610
25Dysmetria (HP:0001310)3.14515817
26Gaze-evoked nystagmus (HP:0000640)3.13225247
27Dysdiadochokinesis (HP:0002075)3.11890003
28Truncal ataxia (HP:0002078)3.10314801
29Neurofibrillary tangles (HP:0002185)3.08667855
30Impaired social interactions (HP:0000735)3.06626601
31Abnormal social behavior (HP:0012433)3.06626601
32Ankle clonus (HP:0011448)3.00002729
33Progressive inability to walk (HP:0002505)2.91662437
34Abnormal eating behavior (HP:0100738)2.86322956
35Urinary bladder sphincter dysfunction (HP:0002839)2.85428736
36Postural instability (HP:0002172)2.82762261
37Papilledema (HP:0001085)2.81560661
38Drooling (HP:0002307)2.80981384
39Excessive salivation (HP:0003781)2.80981384
40Diplopia (HP:0000651)2.78994291
41Abnormality of binocular vision (HP:0011514)2.78994291
42Akinesia (HP:0002304)2.77381194
43Mutism (HP:0002300)2.76079258
44Hemiparesis (HP:0001269)2.72901689
45Clonus (HP:0002169)2.65644673
46Peripheral hypomyelination (HP:0007182)2.63178226
47Epileptiform EEG discharges (HP:0011182)2.59344164
48Sleep apnea (HP:0010535)2.56974974
49Impaired smooth pursuit (HP:0007772)2.56779691
50Apathy (HP:0000741)2.56441938
51Abnormality of the lower motor neuron (HP:0002366)2.54666746
52Urinary urgency (HP:0000012)2.48675473
53EEG with generalized epileptiform discharges (HP:0011198)2.46763570
54Termporal pattern (HP:0011008)2.46644115
55Insidious onset (HP:0003587)2.46644115
56Absent speech (HP:0001344)2.46499379
57Bradykinesia (HP:0002067)2.45301909
58Delusions (HP:0000746)2.43789892
59Scanning speech (HP:0002168)2.40567482
60Insomnia (HP:0100785)2.40086659
61Spastic tetraparesis (HP:0001285)2.38691984
62Inability to walk (HP:0002540)2.38496074
63Genetic anticipation (HP:0003743)2.36817626
64Spastic gait (HP:0002064)2.36156239
65Status epilepticus (HP:0002133)2.35776752
66Stereotypic behavior (HP:0000733)2.31934790
67Generalized myoclonic seizures (HP:0002123)2.29943742
68Hypsarrhythmia (HP:0002521)2.29605524
69Diminished motivation (HP:0000745)2.28104530
70Choreoathetosis (HP:0001266)2.27375235
71Hemiplegia (HP:0002301)2.26015482
72Intention tremor (HP:0002080)2.25169977
73Abnormality of the corticospinal tract (HP:0002492)2.24952319
74Torticollis (HP:0000473)2.24634215
75CNS hypomyelination (HP:0003429)2.24291872
76Focal dystonia (HP:0004373)2.23995679
77Pheochromocytoma (HP:0002666)2.23150603
78Abnormality of ocular smooth pursuit (HP:0000617)2.19303207
79Agitation (HP:0000713)2.17568278
80Polyphagia (HP:0002591)2.16866224
81Psychosis (HP:0000709)2.16820901
82Abnormality of saccadic eye movements (HP:0000570)2.10351650
83Impaired vibratory sensation (HP:0002495)2.10030040
84Rapidly progressive (HP:0003678)2.09287892
85Fetal akinesia sequence (HP:0001989)2.08624146
86Ventricular fibrillation (HP:0001663)2.04916315
87Megalencephaly (HP:0001355)2.04901695
88Morphological abnormality of the pyramidal tract (HP:0002062)2.04392478
89Lower limb muscle weakness (HP:0007340)2.04195790
90Limb dystonia (HP:0002451)1.99154301
91Gait ataxia (HP:0002066)1.98535068
92Neuroendocrine neoplasm (HP:0100634)1.95905820
93Hyperthyroidism (HP:0000836)1.94928805
94Dysmetric saccades (HP:0000641)1.93971856
95Abnormality of salivation (HP:0100755)1.93959265
96Increased circulating renin level (HP:0000848)1.93941225
97Blue irides (HP:0000635)1.93089665
98Craniofacial dystonia (HP:0012179)1.92104835
99Bundle branch block (HP:0011710)1.91668616
100Memory impairment (HP:0002354)1.91210971
101Hypoventilation (HP:0002791)1.90794893
102Retinal dysplasia (HP:0007973)1.89493384
103Neuronal loss in central nervous system (HP:0002529)1.87453239
104Incomplete penetrance (HP:0003829)1.86083011
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84910003
106Amyotrophic lateral sclerosis (HP:0007354)1.84654429
107Lower limb amyotrophy (HP:0007210)1.83925737
108Split foot (HP:0001839)1.82603726
109Spinal canal stenosis (HP:0003416)1.78355871
110Exotropia (HP:0000577)1.77664724
111Protruding tongue (HP:0010808)1.76953041
112Unsteady gait (HP:0002317)1.76913444
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76263970
114Annular pancreas (HP:0001734)1.75838864
115Slow saccadic eye movements (HP:0000514)1.75316691
116Rigidity (HP:0002063)1.74132670
117Bronchomalacia (HP:0002780)1.72528805
118Hypothermia (HP:0002045)1.72467462
119Gait imbalance (HP:0002141)1.72370799
120Lower limb asymmetry (HP:0100559)1.71715964
121Aplasia of the phalanges of the hand (HP:0009802)1.69207610
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.68321175
123Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68321175
124Inappropriate behavior (HP:0000719)1.67338233
125Anosmia (HP:0000458)1.66121498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.69795672
2EPHA44.40651301
3MAP3K93.92920933
4MAP3K43.13232583
5MINK12.73465680
6MAP2K72.62387816
7MAP3K122.52585328
8RIPK42.47569107
9KSR22.37130329
10MARK12.34679361
11NTRK12.33438814
12DAPK22.26650916
13PNCK2.22333993
14MAP2K42.04620284
15PAK61.99262978
16ARAF1.98958520
17NTRK21.93547414
18GRK51.88664699
19PLK21.75443631
20KSR11.70532307
21PRKD31.66716277
22CASK1.66157081
23MAP3K131.64907267
24DAPK11.58988714
25CAMKK11.53859709
26CDK51.49244281
27SIK21.48147956
28TNIK1.39381071
29FES1.33410816
30RIPK11.32559094
31PRKCG1.26490896
32MAP3K21.18031196
33STK381.17950962
34CDK191.15330716
35PTK2B1.15185403
36PRPF4B1.11773103
37CAMK2A1.09186477
38MAPK131.08478123
39RAF11.06198775
40BMPR21.04359367
41NEK61.03876458
42UHMK11.02491513
43NME10.99385451
44CAMKK20.97221207
45LATS20.96717931
46TYRO30.93725208
47CAMK10.92010991
48CAMK2B0.90326462
49GRK70.82927134
50CDK180.81533316
51CDK140.81400351
52CDK150.79991583
53FGR0.79278045
54BRSK10.79087349
55STK110.76079828
56PAK30.75622305
57PHKG20.75317050
58PHKG10.75317050
59DYRK1A0.73542263
60SGK4940.71691511
61SGK2230.71691511
62MAP3K10.69474130
63CDK11A0.69392125
64RET0.68074435
65OXSR10.67887528
66MAP3K110.65963429
67PINK10.64156912
68LMTK20.63920236
69PKN10.63460416
70PRKCH0.63199537
71PRKCE0.63166531
72SGK10.62116685
73MAP2K10.61509312
74CSNK1G20.61468232
75CAMK2D0.57476785
76MUSK0.57149821
77LIMK10.56188850
78TNK20.55678333
79PDK10.55358386
80FER0.54298676
81CAMK2G0.52123771
82PDPK10.51825348
83SGK20.51441025
84CAMK1G0.49609914
85TAOK10.48712744
86MAP3K60.46942966
87GRK60.46847451
88PRKCZ0.45382216
89BRAF0.45369279
90MARK20.44633987
91ALK0.44285391
92FGFR20.43472510
93MOS0.42681367
94IRAK20.41724157
95RPS6KA30.41327896
96FYN0.40426268
97MAP3K70.40196135
98ROCK20.39219839
99MAPK100.38809626
100SGK30.37278653
101CCNB10.36554099
102DAPK30.35131783
103ADRBK10.35062000
104SCYL20.34762622
105TESK10.34338663
106WNK10.34099846
107PRKCA0.33133902
108CAMK40.31122804
109PRKCB0.29831753
110WNK30.29694723
111MAPK120.28074774
112PRKG20.24239720
113MAPK80.22978488
114ERBB20.22554302

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.88331324
2Synaptic vesicle cycle_Homo sapiens_hsa047213.34413968
3Long-term potentiation_Homo sapiens_hsa047202.85900316
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76711898
5GABAergic synapse_Homo sapiens_hsa047272.69925620
6Olfactory transduction_Homo sapiens_hsa047402.68846484
7Circadian entrainment_Homo sapiens_hsa047132.67791431
8Glutamatergic synapse_Homo sapiens_hsa047242.59238966
9Amphetamine addiction_Homo sapiens_hsa050312.59108020
10Morphine addiction_Homo sapiens_hsa050322.42837021
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27509094
12Salivary secretion_Homo sapiens_hsa049702.26241942
13Dopaminergic synapse_Homo sapiens_hsa047282.18115992
14Insulin secretion_Homo sapiens_hsa049111.98638854
15Gastric acid secretion_Homo sapiens_hsa049711.94950505
16Taste transduction_Homo sapiens_hsa047421.90326332
17Collecting duct acid secretion_Homo sapiens_hsa049661.89755369
18Cholinergic synapse_Homo sapiens_hsa047251.89459305
19Long-term depression_Homo sapiens_hsa047301.83861225
20Renin secretion_Homo sapiens_hsa049241.83545925
21Serotonergic synapse_Homo sapiens_hsa047261.79853510
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79772792
23Calcium signaling pathway_Homo sapiens_hsa040201.67152350
24Oxytocin signaling pathway_Homo sapiens_hsa049211.66173665
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60488599
26Vitamin B6 metabolism_Homo sapiens_hsa007501.59835693
27Cocaine addiction_Homo sapiens_hsa050301.58494590
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50409722
29GnRH signaling pathway_Homo sapiens_hsa049121.50358069
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34780229
31Gap junction_Homo sapiens_hsa045401.31956784
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28690130
33cAMP signaling pathway_Homo sapiens_hsa040241.23543539
34Cardiac muscle contraction_Homo sapiens_hsa042601.21310819
35Estrogen signaling pathway_Homo sapiens_hsa049151.16286948
36Vibrio cholerae infection_Homo sapiens_hsa051101.16228373
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15201070
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13278299
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12427193
40Glioma_Homo sapiens_hsa052141.07311591
41Melanogenesis_Homo sapiens_hsa049161.04290563
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02081854
43Type II diabetes mellitus_Homo sapiens_hsa049301.01431879
44Axon guidance_Homo sapiens_hsa043600.97534069
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96564272
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95688189
47Alzheimers disease_Homo sapiens_hsa050100.94469502
48Oxidative phosphorylation_Homo sapiens_hsa001900.92866376
49Pancreatic secretion_Homo sapiens_hsa049720.92363050
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91366322
51ErbB signaling pathway_Homo sapiens_hsa040120.89118651
52Dorso-ventral axis formation_Homo sapiens_hsa043200.88321143
53Oocyte meiosis_Homo sapiens_hsa041140.86939781
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82967959
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81167744
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80677031
57Thyroid hormone synthesis_Homo sapiens_hsa049180.79292779
58Phototransduction_Homo sapiens_hsa047440.77660598
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.77445190
60Choline metabolism in cancer_Homo sapiens_hsa052310.69939979
61Type I diabetes mellitus_Homo sapiens_hsa049400.67748817
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67273645
63Parkinsons disease_Homo sapiens_hsa050120.63736030
64VEGF signaling pathway_Homo sapiens_hsa043700.62860648
65Glucagon signaling pathway_Homo sapiens_hsa049220.62037181
66Dilated cardiomyopathy_Homo sapiens_hsa054140.61843799
67MAPK signaling pathway_Homo sapiens_hsa040100.60325131
68Nitrogen metabolism_Homo sapiens_hsa009100.58095618
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56758417
70African trypanosomiasis_Homo sapiens_hsa051430.55352008
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.52066933
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51132563
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50541960
74Ras signaling pathway_Homo sapiens_hsa040140.49431788
75Bile secretion_Homo sapiens_hsa049760.49231475
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.49132516
77Prion diseases_Homo sapiens_hsa050200.48341386
78Inositol phosphate metabolism_Homo sapiens_hsa005620.46762741
79Rap1 signaling pathway_Homo sapiens_hsa040150.46683188
80Alcoholism_Homo sapiens_hsa050340.45129920
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43970801
82Huntingtons disease_Homo sapiens_hsa050160.43658777
83Arginine biosynthesis_Homo sapiens_hsa002200.41745344
84Arginine and proline metabolism_Homo sapiens_hsa003300.38379881
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37450848
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36241493
87Fatty acid biosynthesis_Homo sapiens_hsa000610.35596266
88Wnt signaling pathway_Homo sapiens_hsa043100.35032541
89Endocytosis_Homo sapiens_hsa041440.32909660
90Mineral absorption_Homo sapiens_hsa049780.32609434
91Rheumatoid arthritis_Homo sapiens_hsa053230.31788869
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31713124
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31594701
94mTOR signaling pathway_Homo sapiens_hsa041500.30909500
95Histidine metabolism_Homo sapiens_hsa003400.29970221
96Insulin signaling pathway_Homo sapiens_hsa049100.29835258
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29676280
98Ovarian steroidogenesis_Homo sapiens_hsa049130.29171626
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28946612
100Non-small cell lung cancer_Homo sapiens_hsa052230.28754686
101Circadian rhythm_Homo sapiens_hsa047100.26981070
102Renal cell carcinoma_Homo sapiens_hsa052110.26117072
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24929649
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24451543
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23247435
106Butanoate metabolism_Homo sapiens_hsa006500.23242793
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22657737
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22316719
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.21589264
110HIF-1 signaling pathway_Homo sapiens_hsa040660.20565598
111Tight junction_Homo sapiens_hsa045300.20403900
112AMPK signaling pathway_Homo sapiens_hsa041520.18676328
113beta-Alanine metabolism_Homo sapiens_hsa004100.16022743
114Hippo signaling pathway_Homo sapiens_hsa043900.14839822
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13815592

Most similar genes based on co-expression Upload to Enrichr

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