SYN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071996.56270583
2omega-hydroxylase P450 pathway (GO:0097267)6.27494348
3fat-soluble vitamin catabolic process (GO:0042363)5.62942331
4vitamin catabolic process (GO:0009111)5.62942331
5desmosome organization (GO:0002934)5.59078319
6endocardial cushion morphogenesis (GO:0003203)4.89791499
7pyrimidine nucleobase catabolic process (GO:0006208)4.76228544
8pattern specification involved in kidney development (GO:0061004)4.74365671
9regulation of male gonad development (GO:2000018)4.51381501
10mesenchyme morphogenesis (GO:0072132)4.35393445
11photoreceptor cell differentiation (GO:0046530)4.33750217
12eye photoreceptor cell differentiation (GO:0001754)4.33750217
13behavioral response to ethanol (GO:0048149)4.32388336
14limb bud formation (GO:0060174)4.26368420
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24455778
16nephron tubule formation (GO:0072079)4.16650202
17protein localization to synapse (GO:0035418)4.13434777
18tachykinin receptor signaling pathway (GO:0007217)4.08731165
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.08501752
20negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.04875097
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.02134943
22vocalization behavior (GO:0071625)4.00070823
23nucleobase catabolic process (GO:0046113)3.96427545
24positive regulation of action potential (GO:0045760)3.93754715
25diterpenoid biosynthetic process (GO:0016102)3.92626264
26gamma-aminobutyric acid transport (GO:0015812)3.92429826
27neuron cell-cell adhesion (GO:0007158)3.83337759
28synaptic vesicle maturation (GO:0016188)3.80906507
29Sertoli cell development (GO:0060009)3.79653623
30glutamate receptor signaling pathway (GO:0007215)3.77725027
31otic vesicle formation (GO:0030916)3.75300532
32positive regulation of male gonad development (GO:2000020)3.71100793
33synaptic transmission, glutamatergic (GO:0035249)3.67839468
34regulation of gene silencing by RNA (GO:0060966)3.63205111
35regulation of posttranscriptional gene silencing (GO:0060147)3.63205111
36regulation of gene silencing by miRNA (GO:0060964)3.63205111
37lymph vessel development (GO:0001945)3.62696719
38short-term memory (GO:0007614)3.62415481
39regulation of mesenchymal cell apoptotic process (GO:2001053)3.57155959
40regulation of timing of cell differentiation (GO:0048505)3.54467138
41neurofilament cytoskeleton organization (GO:0060052)3.47088804
42endothelium development (GO:0003158)3.41259736
43atrioventricular valve morphogenesis (GO:0003181)3.39350259
44signal complex assembly (GO:0007172)3.36222930
45heart valve formation (GO:0003188)3.36125391
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35350825
47gland morphogenesis (GO:0022612)3.35003396
48C4-dicarboxylate transport (GO:0015740)3.32951000
49mesonephros development (GO:0001823)3.32390822
50negative chemotaxis (GO:0050919)3.26265209
51neuronal action potential (GO:0019228)3.25803786
52negative regulation of myoblast differentiation (GO:0045662)3.24880683
53positive regulation of protein kinase C signaling (GO:0090037)3.24281734
54postsynaptic membrane organization (GO:0001941)3.23752105
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23017463
56neuron-neuron synaptic transmission (GO:0007270)3.22807790
57regulation of cell proliferation involved in kidney development (GO:1901722)3.20507740
58urinary tract smooth muscle contraction (GO:0014848)3.20456036
59neurotransmitter-gated ion channel clustering (GO:0072578)3.18768013
60central nervous system projection neuron axonogenesis (GO:0021952)3.17622590
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15962941
62membrane depolarization during action potential (GO:0086010)3.13889368
63regulation of development, heterochronic (GO:0040034)3.13110703
64heart valve morphogenesis (GO:0003179)3.12995854
65negative regulation of cell fate specification (GO:0009996)3.11431782
66neuron recognition (GO:0008038)3.10684096
67neural crest cell development (GO:0014032)3.09834814
68positive regulation of extracellular matrix organization (GO:1903055)3.07717432
69negative regulation of hormone metabolic process (GO:0032351)3.06694237
70negative regulation of hormone biosynthetic process (GO:0032353)3.06694237
71mesenchymal to epithelial transition (GO:0060231)3.05367285
72regulation of apoptotic process involved in morphogenesis (GO:1902337)3.05151153
73response to auditory stimulus (GO:0010996)3.04580847
74developmental pigmentation (GO:0048066)3.04011876
75regulation of action potential (GO:0098900)3.03643531
76mesenchymal cell differentiation involved in renal system development (GO:2001012)3.02181695
77mesenchymal cell differentiation involved in kidney development (GO:0072161)3.02181695
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00434490
79proximal/distal pattern formation (GO:0009954)2.99432710
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98340563
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.98340563
82regulation of translation, ncRNA-mediated (GO:0045974)2.98340563
83transmission of nerve impulse (GO:0019226)2.96586376
84righting reflex (GO:0060013)2.96585005
85negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.96080732
86presynaptic membrane assembly (GO:0097105)2.96014796
87negative regulation of catenin import into nucleus (GO:0035414)2.95525738
88positive regulation of cartilage development (GO:0061036)2.94985491
89glucosamine-containing compound catabolic process (GO:1901072)2.93759225
90regulation of steroid hormone biosynthetic process (GO:0090030)2.91618010
91establishment of planar polarity (GO:0001736)2.90457934
92establishment of tissue polarity (GO:0007164)2.90457934
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90129582
94cell migration in hindbrain (GO:0021535)2.88920539
95regulation of collateral sprouting (GO:0048670)2.87475271
96establishment of mitochondrion localization (GO:0051654)2.83650271
97chondrocyte development (GO:0002063)2.83265414
98axonal fasciculation (GO:0007413)2.83245549
99histone H3-K4 trimethylation (GO:0080182)2.82319826
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82194703
101epoxygenase P450 pathway (GO:0019373)2.81988912
102retinal cone cell development (GO:0046549)2.81695144
103establishment of skin barrier (GO:0061436)2.80832785
104terpenoid biosynthetic process (GO:0016114)2.80753215
105male sex determination (GO:0030238)2.80386921
106negative regulation of cell fate commitment (GO:0010454)2.79769740
107facial nerve structural organization (GO:0021612)2.78590190
108regulation of glucocorticoid metabolic process (GO:0031943)2.78568297
109skin morphogenesis (GO:0043589)2.78535299
110regulation of glomerulus development (GO:0090192)2.76588882
111positive regulation of meiosis (GO:0045836)2.75672648
112cell proliferation involved in kidney development (GO:0072111)2.75081974
113positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74950226
114axon ensheathment in central nervous system (GO:0032291)2.74611051
115central nervous system myelination (GO:0022010)2.74611051
116mesenchymal cell development (GO:0014031)2.74230002
117adult walking behavior (GO:0007628)2.74151317
118central nervous system neuron axonogenesis (GO:0021955)2.73829603
119smooth muscle cell differentiation (GO:0051145)2.72892569
120negative regulation of dendrite development (GO:2000171)2.71792580
121positive regulation of astrocyte differentiation (GO:0048711)2.71458239
122detection of light stimulus involved in sensory perception (GO:0050962)2.70987727
123detection of light stimulus involved in visual perception (GO:0050908)2.70987727
124reflex (GO:0060004)2.70423577
125neuronal action potential propagation (GO:0019227)2.69023463
126retinoic acid metabolic process (GO:0042573)2.68789153
127mammary gland epithelial cell differentiation (GO:0060644)2.66043875
128regulation of pigment cell differentiation (GO:0050932)2.64785744
129mesenchymal cell proliferation (GO:0010463)2.64348732
130respiratory tube development (GO:0030323)2.63397326
131hair cell differentiation (GO:0035315)2.61808118
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61546002
133regulation of water loss via skin (GO:0033561)2.61198859
134regulation of heart morphogenesis (GO:2000826)2.60570246
135synapse assembly (GO:0007416)2.60569426
136positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59155656
137sympathetic nervous system development (GO:0048485)2.58703115
138proline transport (GO:0015824)2.57156770
139positive regulation of meiotic cell cycle (GO:0051446)2.56207250
140presynaptic membrane organization (GO:0097090)2.53697006
141cell differentiation involved in metanephros development (GO:0072202)2.52998856
142neuromuscular synaptic transmission (GO:0007274)2.52320764
143glutamate secretion (GO:0014047)2.52208117
144regulation of synaptic vesicle exocytosis (GO:2000300)2.52034386
145kidney morphogenesis (GO:0060993)2.51712653
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.51341858
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51276862
148regulation of protein kinase C signaling (GO:0090036)2.50974028
149single strand break repair (GO:0000012)2.50730464
150exploration behavior (GO:0035640)2.50725178
151behavioral fear response (GO:0001662)2.50586080
152behavioral defense response (GO:0002209)2.50586080
153peristalsis (GO:0030432)2.50252552
154cranial nerve structural organization (GO:0021604)2.50066390
155detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49784755
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.48695664
157mitochondrion transport along microtubule (GO:0047497)2.47734885
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47734885
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.46890786
160membrane depolarization (GO:0051899)2.46866619
161positive regulation of chondrocyte differentiation (GO:0032332)2.46808826
162locomotory exploration behavior (GO:0035641)2.46625670
163startle response (GO:0001964)2.45928810
164dendrite morphogenesis (GO:0048813)2.45620230
165regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45618764
166behavioral response to nicotine (GO:0035095)2.44515074
167cell surface receptor signaling pathway involved in heart development (GO:0061311)2.44479603
168mesenchymal cell differentiation (GO:0048762)2.44324017
169notochord development (GO:0030903)2.44303570
170regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44290740
171pre-miRNA processing (GO:0031054)2.43987910
172regulation of transcription involved in cell fate commitment (GO:0060850)2.43069057
173regulation of postsynaptic membrane potential (GO:0060078)2.42557527
174positive regulation of dendritic spine morphogenesis (GO:0061003)2.42459744
175DNA double-strand break processing (GO:0000729)2.41640189
176positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40997535
177glycosphingolipid biosynthetic process (GO:0006688)2.40666891
178cochlea development (GO:0090102)2.40165096
179cranial nerve morphogenesis (GO:0021602)2.39300576
180regulation of respiratory system process (GO:0044065)2.39155987
181regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37810558
182positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.37799727
183atrial cardiac muscle cell action potential (GO:0086014)2.37514777
184behavioral response to cocaine (GO:0048148)2.37170867
185auditory behavior (GO:0031223)2.36988242
186olfactory bulb development (GO:0021772)2.36693753
187* neurotransmitter secretion (GO:0007269)2.36442547
188adult behavior (GO:0030534)2.34625035
189regulation of synaptic transmission, glutamatergic (GO:0051966)2.34311619
190synapse organization (GO:0050808)2.33007061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.88689370
2EZH2_22144423_ChIP-Seq_EOC_Human3.41895762
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99361137
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91448049
5ZNF274_21170338_ChIP-Seq_K562_Hela2.88807653
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.78397798
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74587377
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.73834834
9GBX2_23144817_ChIP-Seq_PC3_Human2.59598747
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55790445
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54033026
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53197240
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.53133716
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.47810075
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46860123
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42561243
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37664490
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37664490
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37075745
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36430978
21IGF1R_20145208_ChIP-Seq_DFB_Human2.34586414
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34220164
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.33793320
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.24372538
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15798153
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.14377491
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08032269
28AR_21572438_ChIP-Seq_LNCaP_Human2.05171944
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.00523257
30REST_21632747_ChIP-Seq_MESCs_Mouse2.00372915
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99701064
32TP53_18474530_ChIP-ChIP_U2OS_Human1.98083130
33TAF15_26573619_Chip-Seq_HEK293_Human1.95437772
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.94760108
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90230667
36EWS_26573619_Chip-Seq_HEK293_Human1.82714317
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82493712
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81663247
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80068019
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.80068019
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78568300
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76761930
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73773110
44* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71727326
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70715034
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68470786
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67257558
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64691641
49CBP_20019798_ChIP-Seq_JUKART_Human1.63035412
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63035412
51STAT3_23295773_ChIP-Seq_U87_Human1.62755136
52* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.62628864
53RNF2_27304074_Chip-Seq_NSC_Mouse1.59859481
54* TCF4_23295773_ChIP-Seq_U87_Human1.53377910
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.53333668
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49371542
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47682946
58TP53_16413492_ChIP-PET_HCT116_Human1.46772142
59* DROSHA_22980978_ChIP-Seq_HELA_Human1.46471382
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.41795145
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.41744018
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.40551925
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39999932
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38010664
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36544945
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36497569
67* P300_19829295_ChIP-Seq_ESCs_Human1.35704064
68VDR_22108803_ChIP-Seq_LS180_Human1.34868591
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33019186
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.32418539
71* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32040545
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31771118
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31466061
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31403974
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31162542
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.31119855
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30452297
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30204825
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.28993092
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27425006
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27029327
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25215440
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.23824822
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23366766
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.22323379
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.22241119
87P53_22387025_ChIP-Seq_ESCs_Mouse1.21659261
88* EZH2_27294783_Chip-Seq_NPCs_Mouse1.20588160
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.20526617
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.20212765
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.20206724
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19835326
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18588378
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18002439
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17974354
96VDR_24787735_ChIP-Seq_THP-1_Human1.17285974
97TCF4_22108803_ChIP-Seq_LS180_Human1.17220862
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16757174
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.16581190
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16220457
101AHR_22903824_ChIP-Seq_MCF-7_Human1.13178533
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12630196
103SMAD3_21741376_ChIP-Seq_ESCs_Human1.12228027
104* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11364851
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11209180
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10951082
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10886780
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10886780
109* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10510859
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10189621
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.09161321
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08681684
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.08442846
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08019524
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07497077
116TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07292795
117* FLI1_21867929_ChIP-Seq_TH2_Mouse1.07262456
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07178644
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.06540267
120FUS_26573619_Chip-Seq_HEK293_Human1.06442507
121* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06082073
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05577498
123KDM2B_26808549_Chip-Seq_REH_Human1.05313058
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04637231
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.04273802
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03987010
127SOX9_26525672_Chip-Seq_HEART_Mouse1.03260065
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02953968
129AR_25329375_ChIP-Seq_VCAP_Human1.02793207
130JUN_21703547_ChIP-Seq_K562_Human1.02746618
131RUNX2_22187159_ChIP-Seq_PCA_Human1.02240700
132* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01984701
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01530535
134* AR_19668381_ChIP-Seq_PC3_Human1.01463690
135CJUN_26792858_Chip-Seq_BT549_Human1.00777628
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00697081
137SOX2_19829295_ChIP-Seq_ESCs_Human1.00603742
138NANOG_19829295_ChIP-Seq_ESCs_Human1.00603742
139P300_18555785_Chip-Seq_ESCs_Mouse1.00366397
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99724222
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.99036202
142* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99030364
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98799679
144ER_23166858_ChIP-Seq_MCF-7_Human0.98743172
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.98697936
146BCAT_22108803_ChIP-Seq_LS180_Human0.97860478
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.97563636
148TP53_22573176_ChIP-Seq_HFKS_Human0.96185187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.17450855
2MP0003136_yellow_coat_color5.12713367
3MP0009379_abnormal_foot_pigmentation4.08832914
4MP0005275_abnormal_skin_tensile3.96030263
5MP0000566_synostosis3.57009560
6MP0002736_abnormal_nociception_after3.06781625
7MP0004381_abnormal_hair_follicle2.95072811
8MP0002735_abnormal_chemical_nociception2.91217301
9MP0002249_abnormal_larynx_morphology2.67335826
10MP0002796_impaired_skin_barrier2.67235321
11MP0005423_abnormal_somatic_nervous2.64985526
12MP0009046_muscle_twitch2.60299198
13MP0002098_abnormal_vibrissa_morphology2.58446726
14MP0001188_hyperpigmentation2.56923401
15MP0003890_abnormal_embryonic-extraembry2.55798119
16MP0002734_abnormal_mechanical_nocicepti2.55274637
17MP0003941_abnormal_skin_development2.54055293
18MP0000579_abnormal_nail_morphology2.50225851
19MP0002822_catalepsy2.45006848
20MP0005409_darkened_coat_color2.44458596
21MP0003724_increased_susceptibility_to2.32722398
22MP0006292_abnormal_olfactory_placode2.25937429
23MP0001529_abnormal_vocalization2.19546136
24MP0002272_abnormal_nervous_system2.17250641
25MP0008877_abnormal_DNA_methylation2.11643307
26MP0001984_abnormal_olfaction2.08226651
27MP0003880_abnormal_central_pattern2.06871023
28MP0002102_abnormal_ear_morphology2.03318734
29MP0000049_abnormal_middle_ear1.96119460
30MP0002064_seizures1.90323429
31MP0002009_preneoplasia1.89009978
32MP0000569_abnormal_digit_pigmentation1.82066183
33MP0002063_abnormal_learning/memory/cond1.81948331
34MP0010678_abnormal_skin_adnexa1.76244404
35MP0002938_white_spotting1.75355503
36MP0005551_abnormal_eye_electrophysiolog1.72766614
37MP0003828_pulmonary_edema1.71076694
38MP0001346_abnormal_lacrimal_gland1.70102498
39MP0006276_abnormal_autonomic_nervous1.69318860
40MP0009250_abnormal_appendicular_skeleto1.68982584
41MP0000762_abnormal_tongue_morphology1.67572946
42MP0003385_abnormal_body_wall1.65734050
43MP0001970_abnormal_pain_threshold1.65269301
44MP0002254_reproductive_system_inflammat1.64046739
45MP0002282_abnormal_trachea_morphology1.59101581
46MP0004133_heterotaxia1.55434769
47MP0002733_abnormal_thermal_nociception1.55176821
48MP0000955_abnormal_spinal_cord1.54556333
49MP0004924_abnormal_behavior1.51104130
50MP0005386_behavior/neurological_phenoty1.51104130
51MP0005171_absent_coat_pigmentation1.47568722
52MP0003646_muscle_fatigue1.44925530
53MP0002751_abnormal_autonomic_nervous1.43291950
54MP0003122_maternal_imprinting1.42541444
55MP0008057_abnormal_DNA_replication1.42201983
56MP0004272_abnormal_basement_membrane1.40069139
57MP0002184_abnormal_innervation1.38537652
58MP0005501_abnormal_skin_physiology1.38012391
59MP0001879_abnormal_lymphatic_vessel1.37844452
60MP0001986_abnormal_taste_sensitivity1.36756891
61MP0001485_abnormal_pinna_reflex1.34895295
62MP0002177_abnormal_outer_ear1.33620771
63MP0001501_abnormal_sleep_pattern1.33539684
64MP0003195_calcinosis1.32941351
65MP0004811_abnormal_neuron_physiology1.30946136
66MP0001968_abnormal_touch/_nociception1.30934197
67MP0004142_abnormal_muscle_tone1.29562705
68MP0003718_maternal_effect1.28845990
69MP0008872_abnormal_physiological_respon1.24412505
70MP0005623_abnormal_meninges_morphology1.23702187
71MP0003121_genomic_imprinting1.22423266
72* MP0002882_abnormal_neuron_morphology1.20355128
73MP0000428_abnormal_craniofacial_morphol1.19372965
74MP0003119_abnormal_digestive_system1.17155241
75MP0000377_abnormal_hair_follicle1.17114915
76MP0004742_abnormal_vestibular_system1.14075542
77MP0008058_abnormal_DNA_repair1.10856418
78MP0005646_abnormal_pituitary_gland1.10498562
79MP0005508_abnormal_skeleton_morphology1.09146553
80MP0001486_abnormal_startle_reflex1.09017900
81MP0002229_neurodegeneration1.08891771
82MP0002752_abnormal_somatic_nervous1.07612745
83MP0000778_abnormal_nervous_system1.07008327
84MP0000372_irregular_coat_pigmentation1.06417484
85MP0005248_abnormal_Harderian_gland1.06090104
86MP0003755_abnormal_palate_morphology1.05993834
87MP0003938_abnormal_ear_development1.05977097
88MP0000163_abnormal_cartilage_morphology1.04170866
89MP0005253_abnormal_eye_physiology1.04010478
90MP0001340_abnormal_eyelid_morphology1.02831677
91MP0002116_abnormal_craniofacial_bone1.02801762
92MP0009384_cardiac_valve_regurgitation1.01661804
93MP0004270_analgesia1.00156218
94MP0002066_abnormal_motor_capabilities/c0.99910869
95MP0010771_integument_phenotype0.99165333
96MP0003567_abnormal_fetal_cardiomyocyte0.98527587
97MP0005595_abnormal_vascular_smooth0.97216402
98MP0002090_abnormal_vision0.96711499
99MP0003633_abnormal_nervous_system0.96586674
100MP0000383_abnormal_hair_follicle0.96511506
101MP0000026_abnormal_inner_ear0.95570693
102MP0002152_abnormal_brain_morphology0.95256768
103MP0001293_anophthalmia0.94267773
104MP0001299_abnormal_eye_distance/0.93567417
105MP0002233_abnormal_nose_morphology0.91870637
106* MP0003861_abnormal_nervous_system0.91776039
107MP0001958_emphysema0.89257633
108MP0002557_abnormal_social/conspecific_i0.88107656
109MP0000631_abnormal_neuroendocrine_gland0.87609167
110MP0001440_abnormal_grooming_behavior0.87181085
111MP0005257_abnormal_intraocular_pressure0.85305357
112MP0006138_congestive_heart_failure0.85261947
113MP0005499_abnormal_olfactory_system0.84646244
114MP0005394_taste/olfaction_phenotype0.84646244
115MP0009745_abnormal_behavioral_response0.84419219
116MP0003303_peritoneal_inflammation0.84140465
117MP0003937_abnormal_limbs/digits/tail_de0.83899160
118MP0005645_abnormal_hypothalamus_physiol0.83891372
119MP0002638_abnormal_pupillary_reflex0.82146747
120MP0003631_nervous_system_phenotype0.81267911
121MP0003698_abnormal_male_reproductive0.80675207
122MP0002277_abnormal_respiratory_mucosa0.79421687
123MP0004885_abnormal_endolymph0.79158347
124MP0005174_abnormal_tail_pigmentation0.79145078
125MP0002933_joint_inflammation0.78863408
126MP0000516_abnormal_urinary_system0.78125183
127MP0005367_renal/urinary_system_phenotyp0.78125183
128MP0001216_abnormal_epidermal_layer0.77891450
129MP0006072_abnormal_retinal_apoptosis0.77832425
130* MP0003635_abnormal_synaptic_transmissio0.77644913
131MP0000647_abnormal_sebaceous_gland0.75997227
132MP0002060_abnormal_skin_morphology0.75609094
133MP0010030_abnormal_orbit_morphology0.75111056
134MP0005195_abnormal_posterior_eye0.74874199
135MP0001919_abnormal_reproductive_system0.74646353
136MP0008569_lethality_at_weaning0.73778418
137MP0000465_gastrointestinal_hemorrhage0.72414922
138MP0005388_respiratory_system_phenotype0.71751655
139MP0002133_abnormal_respiratory_system0.71751655
140MP0003566_abnormal_cell_adhesion0.71505879
141MP0001324_abnormal_eye_pigmentation0.71234665
142MP0002653_abnormal_ependyma_morphology0.69643122
143MP0005165_increased_susceptibility_to0.69207578
144MP0002160_abnormal_reproductive_system0.69015219
145MP0002069_abnormal_eating/drinking_beha0.68980812
146MP0000432_abnormal_head_morphology0.68380341
147MP0005197_abnormal_uvea_morphology0.68311630
148MP0004147_increased_porphyrin_level0.66352616
149MP0005390_skeleton_phenotype0.66195979
150MP0002067_abnormal_sensory_capabilities0.64876116
151MP0003942_abnormal_urinary_system0.64839363
152MP0001177_atelectasis0.63285074
153MP0004859_abnormal_synaptic_plasticity0.62673921
154MP0002572_abnormal_emotion/affect_behav0.62567607
155MP0002111_abnormal_tail_morphology0.62318810
156MP0004085_abnormal_heartbeat0.62120280
157MP0001963_abnormal_hearing_physiology0.61644292
158MP0001905_abnormal_dopamine_level0.60237395
159MP0000613_abnormal_salivary_gland0.59896273
160MP0002109_abnormal_limb_morphology0.59429560
161MP0001502_abnormal_circadian_rhythm0.59275746
162MP0008789_abnormal_olfactory_epithelium0.58758824
163MP0003137_abnormal_impulse_conducting0.58741623
164MP0003787_abnormal_imprinting0.58537816
165MP0002115_abnormal_skeleton_extremities0.57039670
166MP0003935_abnormal_craniofacial_develop0.57005585

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of secondary sexual hair (HP:0009888)6.23700270
2Abnormality of the axillary hair (HP:0100134)6.23700270
3Increased IgE level (HP:0003212)6.10079489
4Humeroradial synostosis (HP:0003041)5.75714931
5Synostosis involving the elbow (HP:0003938)5.75714931
6Abnormal sex determination (HP:0012244)5.13581962
7Sex reversal (HP:0012245)5.13581962
8Onycholysis (HP:0001806)4.90183018
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.44342788
10Focal seizures (HP:0007359)4.06559269
11Hyperventilation (HP:0002883)3.71427828
12Neonatal short-limb short stature (HP:0008921)3.70850451
13True hermaphroditism (HP:0010459)3.49809778
14Abnormality of the labia minora (HP:0012880)3.42996640
15Concave nail (HP:0001598)3.34827094
16Sparse scalp hair (HP:0002209)3.27747118
17Oligodactyly (HP:0012165)3.23444012
18Gaze-evoked nystagmus (HP:0000640)3.21965905
19Atonic seizures (HP:0010819)3.13583936
20Occipital encephalocele (HP:0002085)3.11395483
21Hypoplasia of the iris (HP:0007676)3.09136457
22Myokymia (HP:0002411)3.06693844
23Aplasia involving bones of the upper limbs (HP:0009823)3.06302449
24Aplasia of the phalanges of the hand (HP:0009802)3.06302449
25Aplasia involving bones of the extremities (HP:0009825)3.06302449
26Broad-based gait (HP:0002136)3.05414677
27Progressive cerebellar ataxia (HP:0002073)3.05321522
28Bronchomalacia (HP:0002780)2.96398041
29Dialeptic seizures (HP:0011146)2.87962006
30Epileptic encephalopathy (HP:0200134)2.84073201
31Dry hair (HP:0011359)2.78326728
32Drooling (HP:0002307)2.76194246
33Popliteal pterygium (HP:0009756)2.71985366
34Hypotrichosis (HP:0001006)2.68655603
35Tracheomalacia (HP:0002779)2.67380083
36Inability to walk (HP:0002540)2.67177712
37Absent speech (HP:0001344)2.67003654
38Obstructive sleep apnea (HP:0002870)2.66778862
39Congenital sensorineural hearing impairment (HP:0008527)2.62356733
40Septo-optic dysplasia (HP:0100842)2.62136067
41Protruding tongue (HP:0010808)2.61535055
42Erythroderma (HP:0001019)2.60846863
43Hepatoblastoma (HP:0002884)2.53913051
4411 pairs of ribs (HP:0000878)2.52078378
45Intestinal atresia (HP:0011100)2.50803181
46Optic nerve hypoplasia (HP:0000609)2.48736547
47Hypophosphatemic rickets (HP:0004912)2.47180797
48Acanthosis nigricans (HP:0000956)2.45983959
49Excessive salivation (HP:0003781)2.45269859
50Pancreatic cysts (HP:0001737)2.44891295
51Retinal dysplasia (HP:0007973)2.43930218
52Generalized tonic-clonic seizures (HP:0002069)2.43066807
53Congenital ichthyosiform erythroderma (HP:0007431)2.42769206
54Hypothermia (HP:0002045)2.42223633
55Renal tubular acidosis (HP:0001947)2.40622729
56Urinary bladder sphincter dysfunction (HP:0002839)2.36990972
57Amyotrophic lateral sclerosis (HP:0007354)2.36210589
58Absent hair (HP:0002298)2.34759758
59Limb dystonia (HP:0002451)2.32936566
60Follicular hyperkeratosis (HP:0007502)2.30749414
61Vaginal atresia (HP:0000148)2.28188209
62Genital tract atresia (HP:0001827)2.28153919
63Anophthalmia (HP:0000528)2.27904814
64Natal tooth (HP:0000695)2.25226716
65Fibular hypoplasia (HP:0003038)2.23050597
66Gait imbalance (HP:0002141)2.21791736
67Colon cancer (HP:0003003)2.21483080
68Impaired vibration sensation in the lower limbs (HP:0002166)2.20340447
69Bifid scrotum (HP:0000048)2.19591162
70Abnormality of macular pigmentation (HP:0008002)2.18399966
71Polyphagia (HP:0002591)2.18035462
72Congenital stationary night blindness (HP:0007642)2.17882818
73Soft skin (HP:0000977)2.17641599
74Bifid tongue (HP:0010297)2.16109560
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15820590
76Woolly hair (HP:0002224)2.15149691
77Brittle hair (HP:0002299)2.15075378
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.14176310
79Nephronophthisis (HP:0000090)2.13291135
80Hypergammaglobulinemia (HP:0010702)2.13274200
81Action tremor (HP:0002345)2.12724255
82Progressive inability to walk (HP:0002505)2.11533055
83Abnormality of the astrocytes (HP:0100707)2.11397881
84Astrocytoma (HP:0009592)2.11397881
85Median cleft lip (HP:0000161)2.11273456
86Pancreatic fibrosis (HP:0100732)2.10314775
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10287626
88Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08665048
89Corneal dystrophy (HP:0001131)2.08412350
90Abnormality of midbrain morphology (HP:0002418)2.07941994
91Molar tooth sign on MRI (HP:0002419)2.07941994
92Lissencephaly (HP:0001339)2.07615064
93Knee flexion contracture (HP:0006380)2.07034709
94Myelomeningocele (HP:0002475)2.06740240
95Focal motor seizures (HP:0011153)2.06319546
96Ependymoma (HP:0002888)2.05951708
97Renal hypoplasia (HP:0000089)2.05776798
98Genetic anticipation (HP:0003743)2.05183679
99Anhidrosis (HP:0000970)2.03598684
100Midline defect of the nose (HP:0004122)2.02727796
101Hemiparesis (HP:0001269)2.02084559
102Abolished electroretinogram (ERG) (HP:0000550)2.01957641
103Hypoplastic left heart (HP:0004383)2.01938918
104Nonprogressive disorder (HP:0003680)2.01831144
105Aqueductal stenosis (HP:0002410)2.01273626
106Chronic hepatic failure (HP:0100626)2.00326627
107Hypoplastic heart (HP:0001961)2.00308391
108Corneal erosion (HP:0200020)2.00185623
109Epileptiform EEG discharges (HP:0011182)1.99993149
110Small hand (HP:0200055)1.99612275
111Attenuation of retinal blood vessels (HP:0007843)1.97982407
112Abnormal pupillary function (HP:0007686)1.97066618
113Hyperglycinemia (HP:0002154)1.96705527
114Thyroid-stimulating hormone excess (HP:0002925)1.96677679
115Cutaneous finger syndactyly (HP:0010554)1.96217987
116Absence seizures (HP:0002121)1.94460356
117Bilateral microphthalmos (HP:0007633)1.94311367
118Stomach cancer (HP:0012126)1.94071989
119Hemiplegia (HP:0002301)1.93624857
120Overgrowth (HP:0001548)1.92910664
121Thickened helices (HP:0000391)1.92602022
122Amblyopia (HP:0000646)1.92578210
123Cupped ear (HP:0000378)1.92240537
124Hypsarrhythmia (HP:0002521)1.90033317
125Abnormality of dental color (HP:0011073)1.89685029
126Abnormality of the phalanges of the 5th finger (HP:0004213)1.89642208
127Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.89397840
128Abnormality of the humeroradial joint (HP:0100744)1.89251119
129Microglossia (HP:0000171)1.89176605
130EEG with generalized epileptiform discharges (HP:0011198)1.89102033
131Cutaneous syndactyly (HP:0012725)1.88023637
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.87746086
133Fragile nails (HP:0001808)1.86911514
134Pendular nystagmus (HP:0012043)1.86487854
135Labial hypoplasia (HP:0000066)1.86291251
136Oligodactyly (hands) (HP:0001180)1.86188457
137Glioma (HP:0009733)1.85907531
138Medial flaring of the eyebrow (HP:0010747)1.85858600
139Abnormality of the middle phalanges of the toes (HP:0010183)1.85508572
140Impaired social interactions (HP:0000735)1.84210652
141Abnormal social behavior (HP:0012433)1.84210652
142Conical tooth (HP:0000698)1.84023407
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83297504
144Advanced eruption of teeth (HP:0006288)1.82942500
145Renal tubular dysfunction (HP:0000124)1.81501752
146Supernumerary spleens (HP:0009799)1.80145447
147Abnormality of the renal medulla (HP:0100957)1.79124965
148Submucous cleft hard palate (HP:0000176)1.78927828
149Spastic gait (HP:0002064)1.78438068
150Scrotal hypoplasia (HP:0000046)1.78182643
151Birth length less than 3rd percentile (HP:0003561)1.78153478
152Abnormality of the nasolacrimal system (HP:0000614)1.78146864
153Urinary urgency (HP:0000012)1.78100013
154Febrile seizures (HP:0002373)1.77853541
155Atelectasis (HP:0100750)1.77836988
156Bony spicule pigmentary retinopathy (HP:0007737)1.76939330
157Curly hair (HP:0002212)1.75780575
158Hyperglycinuria (HP:0003108)1.75699027
159Spastic tetraplegia (HP:0002510)1.74331618
160Absent eyebrow (HP:0002223)1.73717087
161Congenital primary aphakia (HP:0007707)1.73418290
162Reduced antithrombin III activity (HP:0001976)1.73269114
163Narrow forehead (HP:0000341)1.72678145
164Sleep apnea (HP:0010535)1.72653802
165Male pseudohermaphroditism (HP:0000037)1.72310684
166Type II lissencephaly (HP:0007260)1.71350915
167Aplasia/hypoplasia of the uterus (HP:0008684)1.70353220
168Short tibia (HP:0005736)1.70257678
169Volvulus (HP:0002580)1.69342696
170Palpebral edema (HP:0100540)1.69206257
171Recurrent corneal erosions (HP:0000495)1.69025086
172Coronal craniosynostosis (HP:0004440)1.68869678
173Hypoplastic female external genitalia (HP:0012815)1.68809237
174Dysdiadochokinesis (HP:0002075)1.68720960
175Sclerocornea (HP:0000647)1.68468341
176Abnormality of the pubic bones (HP:0003172)1.68248378
177Hypoparathyroidism (HP:0000829)1.67884249
178Anencephaly (HP:0002323)1.67623295
179Aplasia cutis congenita (HP:0001057)1.67565144
180Abnormality of the right ventricle (HP:0001707)1.67363624
181Long nose (HP:0003189)1.67341679
182Morphological abnormality of the middle ear (HP:0008609)1.67335601
183Abnormality of the lacrimal duct (HP:0011481)1.67229046
184Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67052334
185Abnormality of the corticospinal tract (HP:0002492)1.66553752
186Absent septum pellucidum (HP:0001331)1.65890019
187Specific learning disability (HP:0001328)1.65387356
188Laryngomalacia (HP:0001601)1.65307853
189Metabolic alkalosis (HP:0200114)1.65230022
190Premature rupture of membranes (HP:0001788)1.65181902
191Dandy-Walker malformation (HP:0001305)1.64903962
192Absent hand (HP:0004050)1.64775134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.74541614
2IRAK33.63409721
3FRK3.48388603
4TNIK3.39739483
5FER3.17759410
6MKNK23.08441937
7FES2.65342129
8WNK32.64652147
9MUSK2.55747269
10TRIM282.35424160
11MAP3K42.32277518
12NUAK12.29236932
13EPHA42.24555761
14NLK2.19015013
15PNCK2.02400494
16BCR2.02018116
17MAP4K21.98715450
18PBK1.95760359
19BMPR1B1.95524457
20HIPK21.90192648
21CAMK1G1.76511615
22PINK11.75262705
23YES11.68231573
24PIM21.65561203
25CSNK1G21.64268680
26PKN11.64135735
27TLK11.55938593
28MKNK11.55104760
29LATS11.51638769
30MAPK131.50987938
31EPHA31.46569273
32STK161.44054153
33MAP2K71.43467904
34CSNK1G31.37969576
35STK241.37567084
36PRKCG1.37082742
37MAPK151.35628518
38GRK11.33535806
39NME11.30556663
40CLK11.29402003
41CAMK11.28957488
42PLK21.28863982
43DMPK1.28752952
44ACVR1B1.22921407
45TIE11.18375998
46IRAK11.17182349
47MAP3K121.05341296
48DAPK21.02943093
49ROCK11.01683743
50PLK31.00087528
51RPS6KL10.97294808
52RPS6KC10.97294808
53PRPF4B0.96186511
54RPS6KA20.95836035
55DYRK30.95362595
56EPHB20.95270967
57ADRBK20.89426954
58PRKCE0.89168911
59OXSR10.88196648
60BLK0.86702389
61PLK40.85333805
62UHMK10.85080963
63PRKD30.85012212
64IRAK40.83659796
65TEC0.83368449
66CDK50.83205349
67NTRK30.80917251
68FGFR20.80813255
69CAMKK20.80503892
70DAPK10.79736065
71ERBB30.79488316
72PHKG10.79438657
73PHKG20.79438657
74SIK20.78508528
75RPS6KA60.77472525
76CAMK2B0.77454990
77ADRBK10.77270560
78CAMK1D0.75237017
79BMPR20.75155757
80STK38L0.74628163
81EIF2AK20.73880185
82MARK10.73412431
83EPHB10.73230500
84CDK190.72944966
85TAF10.72476147
86PRKAA20.69435564
87DYRK1A0.68719623
88VRK10.68631739
89CSNK1D0.67417164
90NEK60.66657418
91MARK20.64795787
92CSNK1G10.63175244
93MAP2K40.62094113
94CSK0.61835444
95CSNK1A1L0.61679714
96MST40.60103951
97CAMK2D0.59422109
98MAPK40.59024291
99SGK2230.58908396
100SGK4940.58908396
101MAP2K20.57020331
102PRKCZ0.56869547
103INSRR0.56558244
104GRK50.56306564
105SIK30.55038543
106CSNK1E0.54878118
107NTRK20.54809783
108ZAK0.54672617
109TXK0.54249283
110CSNK1A10.53288712
111CAMK2A0.52800083
112IKBKB0.51515870
113STK30.50257953
114KSR10.48500339
115NME20.47797931
116ATM0.47525409
117AKT30.46915772
118PRKG10.46873152
119MAPK120.46249979
120BRSK20.46114791
121STK110.45555889
122DYRK20.44918007
123CDK30.44806159
124TYRO30.44741204
125TSSK60.44635409
126PLK10.44156068
127MAP3K140.43741856
128CDC70.43442406
129CDK180.42784679
130CAMK40.41767611
131BRD40.40948287
132CAMK2G0.40396981
133SGK20.40154181
134ATR0.40118932
135SRPK10.39426220
136MAPK70.39230404
137PAK30.38703446
138PRKACB0.38457349
139PAK60.38306635
140WEE10.37364097
141PRKACA0.37197003
142GRK70.37034221
143PRKD20.36912830
144PRKDC0.36831104
145PRKAA10.36830623
146MAPK100.35577255
147MINK10.35398292
148* GSK3B0.34888230
149HCK0.33985694
150LCK0.33819805
151IRAK20.32668825
152PRKG20.31284432
153RPS6KA50.30094365
154ABL10.28955216
155MAPK110.28765087
156DYRK1B0.28498691

Predicted pathways (KEGG)

RankGene SetZ-score
1Retinol metabolism_Homo sapiens_hsa008302.43947596
2Basal cell carcinoma_Homo sapiens_hsa052172.23686366
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22124735
4Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.99803853
5Nicotine addiction_Homo sapiens_hsa050331.91679962
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88463094
7Butanoate metabolism_Homo sapiens_hsa006501.83677867
8Non-homologous end-joining_Homo sapiens_hsa034501.81207906
9Propanoate metabolism_Homo sapiens_hsa006401.73847565
10Melanogenesis_Homo sapiens_hsa049161.72380712
11Selenocompound metabolism_Homo sapiens_hsa004501.71822718
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71585361
13GABAergic synapse_Homo sapiens_hsa047271.70108815
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68935591
15Phototransduction_Homo sapiens_hsa047441.68356515
16Axon guidance_Homo sapiens_hsa043601.68006947
17African trypanosomiasis_Homo sapiens_hsa051431.59323395
18Malaria_Homo sapiens_hsa051441.59002638
19Synaptic vesicle cycle_Homo sapiens_hsa047211.55860894
20Melanoma_Homo sapiens_hsa052181.53180385
21Sphingolipid metabolism_Homo sapiens_hsa006001.52085909
22Wnt signaling pathway_Homo sapiens_hsa043101.48549033
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47740516
24Cocaine addiction_Homo sapiens_hsa050301.46394178
25Glutamatergic synapse_Homo sapiens_hsa047241.45176129
26TGF-beta signaling pathway_Homo sapiens_hsa043501.41478415
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39896867
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34739351
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30310802
30Hedgehog signaling pathway_Homo sapiens_hsa043401.28598596
31Basal transcription factors_Homo sapiens_hsa030221.27251625
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25907889
33ECM-receptor interaction_Homo sapiens_hsa045121.25278489
34Morphine addiction_Homo sapiens_hsa050321.24227221
35cAMP signaling pathway_Homo sapiens_hsa040241.23593234
36Protein export_Homo sapiens_hsa030601.20052408
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.19310597
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17729488
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17650989
40Taste transduction_Homo sapiens_hsa047421.15985506
41Circadian entrainment_Homo sapiens_hsa047131.15436747
42Salivary secretion_Homo sapiens_hsa049701.13452869
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13243298
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10695203
45Serotonergic synapse_Homo sapiens_hsa047261.07934680
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06829540
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06336068
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06083120
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05524715
50Fanconi anemia pathway_Homo sapiens_hsa034601.05067654
51Other glycan degradation_Homo sapiens_hsa005111.04307218
52Hippo signaling pathway_Homo sapiens_hsa043901.03365312
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.99581316
54RNA polymerase_Homo sapiens_hsa030200.99450614
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97505644
56Cholinergic synapse_Homo sapiens_hsa047250.96506210
57Rheumatoid arthritis_Homo sapiens_hsa053230.95824787
58Arachidonic acid metabolism_Homo sapiens_hsa005900.94160261
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94004249
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93170258
61Calcium signaling pathway_Homo sapiens_hsa040200.92876325
62Mineral absorption_Homo sapiens_hsa049780.90869529
63Ras signaling pathway_Homo sapiens_hsa040140.90386878
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90054829
65Oocyte meiosis_Homo sapiens_hsa041140.89213642
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88639194
67Graft-versus-host disease_Homo sapiens_hsa053320.88205290
68Fatty acid elongation_Homo sapiens_hsa000620.88029711
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87449446
70Cardiac muscle contraction_Homo sapiens_hsa042600.85902960
71Long-term depression_Homo sapiens_hsa047300.85697467
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85576714
73Tight junction_Homo sapiens_hsa045300.83913071
74Insulin secretion_Homo sapiens_hsa049110.83846450
75ABC transporters_Homo sapiens_hsa020100.83619021
76Adherens junction_Homo sapiens_hsa045200.83323366
77Steroid biosynthesis_Homo sapiens_hsa001000.83016717
78Linoleic acid metabolism_Homo sapiens_hsa005910.82953898
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82607337
80Ovarian steroidogenesis_Homo sapiens_hsa049130.81904531
81Gastric acid secretion_Homo sapiens_hsa049710.81667435
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81221449
83Pathways in cancer_Homo sapiens_hsa052000.81200767
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.80767738
85Protein digestion and absorption_Homo sapiens_hsa049740.79320501
86Nitrogen metabolism_Homo sapiens_hsa009100.78862934
87Rap1 signaling pathway_Homo sapiens_hsa040150.78627536
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76375122
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75950979
90Tryptophan metabolism_Homo sapiens_hsa003800.75181223
91ErbB signaling pathway_Homo sapiens_hsa040120.74653727
92mRNA surveillance pathway_Homo sapiens_hsa030150.73906726
93Oxytocin signaling pathway_Homo sapiens_hsa049210.73726389
94Renin secretion_Homo sapiens_hsa049240.73505332
95Hematopoietic cell lineage_Homo sapiens_hsa046400.72617072
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69645398
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68410868
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68011729
99Amphetamine addiction_Homo sapiens_hsa050310.67625539
100Ether lipid metabolism_Homo sapiens_hsa005650.67509284
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66462244
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64821716
103MicroRNAs in cancer_Homo sapiens_hsa052060.64666885
104beta-Alanine metabolism_Homo sapiens_hsa004100.64251931
105Pancreatic secretion_Homo sapiens_hsa049720.63941895
106Lysine degradation_Homo sapiens_hsa003100.63870763
107Homologous recombination_Homo sapiens_hsa034400.63469564
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63195920
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61264336
110RNA transport_Homo sapiens_hsa030130.60163033
111RNA degradation_Homo sapiens_hsa030180.59979519
112Allograft rejection_Homo sapiens_hsa053300.59870612
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59419852
114Prostate cancer_Homo sapiens_hsa052150.59063195
115p53 signaling pathway_Homo sapiens_hsa041150.58785111
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57323160
117Amoebiasis_Homo sapiens_hsa051460.57063733
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56510582
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.56290240
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56145599
121Regulation of autophagy_Homo sapiens_hsa041400.55884170
122Ribosome_Homo sapiens_hsa030100.55327679
123Caffeine metabolism_Homo sapiens_hsa002320.54524223
124Olfactory transduction_Homo sapiens_hsa047400.54263979
125Asthma_Homo sapiens_hsa053100.54175240
126Collecting duct acid secretion_Homo sapiens_hsa049660.53654628
127Gap junction_Homo sapiens_hsa045400.52475868
128Circadian rhythm_Homo sapiens_hsa047100.51200882
129Huntingtons disease_Homo sapiens_hsa050160.50780370
130Dorso-ventral axis formation_Homo sapiens_hsa043200.50682824
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.50658579
132Parkinsons disease_Homo sapiens_hsa050120.49726008
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49457960
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49010206
135Fatty acid biosynthesis_Homo sapiens_hsa000610.48791486
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48525798
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.47991190
138Proteoglycans in cancer_Homo sapiens_hsa052050.47285856
139Long-term potentiation_Homo sapiens_hsa047200.47141576
140Autoimmune thyroid disease_Homo sapiens_hsa053200.47057085
141T cell receptor signaling pathway_Homo sapiens_hsa046600.45810894
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45733441
143Chemical carcinogenesis_Homo sapiens_hsa052040.45574920
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.45490626
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44758809
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44621929
147Dilated cardiomyopathy_Homo sapiens_hsa054140.44293607
148Dopaminergic synapse_Homo sapiens_hsa047280.44181533
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43486563
150Purine metabolism_Homo sapiens_hsa002300.43450326
151Alcoholism_Homo sapiens_hsa050340.43331699
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.42781333
153Oxidative phosphorylation_Homo sapiens_hsa001900.40139209
154Vitamin B6 metabolism_Homo sapiens_hsa007500.40053573
155Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37955709

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