SYNCRIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.49677819
2nuclear pore organization (GO:0006999)5.34932661
3establishment of integrated proviral latency (GO:0075713)4.90883562
4DNA unwinding involved in DNA replication (GO:0006268)4.81924988
5mitotic sister chromatid cohesion (GO:0007064)4.77683373
6protein localization to kinetochore (GO:0034501)4.49042330
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19794379
8pore complex assembly (GO:0046931)4.16798114
9mitotic nuclear envelope disassembly (GO:0007077)4.12963179
10nuclear envelope disassembly (GO:0051081)3.90806134
11membrane disassembly (GO:0030397)3.90806134
12protein localization to chromosome, centromeric region (GO:0071459)3.84513693
13mitotic chromosome condensation (GO:0007076)3.82788594
14regulation of RNA export from nucleus (GO:0046831)3.78833881
15double-strand break repair via nonhomologous end joining (GO:0006303)3.77883996
16non-recombinational repair (GO:0000726)3.77883996
17IMP biosynthetic process (GO:0006188)3.77803872
18regulation of spindle organization (GO:0090224)3.68893431
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68552615
20mitotic metaphase plate congression (GO:0007080)3.65143682
21DNA duplex unwinding (GO:0032508)3.64241051
22sister chromatid segregation (GO:0000819)3.63046663
23kinetochore organization (GO:0051383)3.62940648
24DNA geometric change (GO:0032392)3.61826384
25dosage compensation (GO:0007549)3.61176043
26positive regulation of chromosome segregation (GO:0051984)3.60918077
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.60649495
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.60649495
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.60649495
30establishment of viral latency (GO:0019043)3.57524383
31DNA replication initiation (GO:0006270)3.56664022
32protein complex localization (GO:0031503)3.56005786
33negative regulation of RNA splicing (GO:0033119)3.53676329
34regulation of sister chromatid cohesion (GO:0007063)3.49224699
35pre-miRNA processing (GO:0031054)3.45552402
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45247610
37DNA replication-dependent nucleosome organization (GO:0034723)3.38993197
38DNA replication-dependent nucleosome assembly (GO:0006335)3.38993197
39metaphase plate congression (GO:0051310)3.37114495
40DNA ligation (GO:0006266)3.37050885
41regulation of DNA endoreduplication (GO:0032875)3.36665265
42chromosome condensation (GO:0030261)3.36652542
43DNA strand elongation involved in DNA replication (GO:0006271)3.36081443
44cellular protein complex localization (GO:0034629)3.35939536
45DNA topological change (GO:0006265)3.35280031
46ribosome assembly (GO:0042255)3.35036526
47regulation of mitotic spindle organization (GO:0060236)3.34320456
48negative regulation of DNA repair (GO:0045738)3.33534760
49IMP metabolic process (GO:0046040)3.32558463
50nucleobase biosynthetic process (GO:0046112)3.30873787
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.27648154
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27648154
53negative regulation of mitotic sister chromatid segregation (GO:0033048)3.27648154
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.27648154
55negative regulation of sister chromatid segregation (GO:0033046)3.27648154
56negative regulation of mRNA processing (GO:0050686)3.24120755
57regulation of histone H3-K9 methylation (GO:0051570)3.22847294
58mitotic recombination (GO:0006312)3.22470629
59folic acid-containing compound biosynthetic process (GO:0009396)3.21322070
60mitotic sister chromatid segregation (GO:0000070)3.21205220
61negative regulation of histone methylation (GO:0031061)3.20786848
62alternative mRNA splicing, via spliceosome (GO:0000380)3.19987743
63DNA replication-independent nucleosome assembly (GO:0006336)3.19503343
64DNA replication-independent nucleosome organization (GO:0034724)3.19503343
65DNA strand elongation (GO:0022616)3.19500163
66formation of translation preinitiation complex (GO:0001731)3.13921751
67heterochromatin organization (GO:0070828)3.12549592
68chromatin assembly or disassembly (GO:0006333)3.11814671
69nuclear envelope organization (GO:0006998)3.11529943
70chromatin remodeling at centromere (GO:0031055)3.11373821
71ribosome biogenesis (GO:0042254)3.10507887
72CENP-A containing nucleosome assembly (GO:0034080)3.08930053
73translesion synthesis (GO:0019985)3.08837923
74RNA-dependent DNA replication (GO:0006278)3.08279820
75purine nucleobase biosynthetic process (GO:0009113)3.07805182
76DNA packaging (GO:0006323)3.07777189
77ribosomal large subunit biogenesis (GO:0042273)3.06468790
78attachment of spindle microtubules to kinetochore (GO:0008608)3.05717288
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03021517
80telomere maintenance via telomere lengthening (GO:0010833)3.02818201
81chromosome segregation (GO:0007059)3.02640897
82chromatin assembly (GO:0031497)3.02207334
83regulation of centriole replication (GO:0046599)3.00558751
84termination of RNA polymerase II transcription (GO:0006369)3.00317060
85regulation of centrosome cycle (GO:0046605)3.00202711
86telomere maintenance via recombination (GO:0000722)2.99243854
87DNA conformation change (GO:0071103)2.99031068
88regulation of translational termination (GO:0006449)2.97441563
89DNA replication checkpoint (GO:0000076)2.97109564
90regulation of centrosome duplication (GO:0010824)2.96791793
91regulation of chromosome segregation (GO:0051983)2.96283818
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96052483
93telomere maintenance via semi-conservative replication (GO:0032201)2.95927818
94negative regulation of mRNA metabolic process (GO:1903312)2.95035579
95* RNA stabilization (GO:0043489)2.93715119
96* mRNA stabilization (GO:0048255)2.93715119
97establishment of chromosome localization (GO:0051303)2.93306685
98ATP-dependent chromatin remodeling (GO:0043044)2.93299103
99glucocorticoid receptor signaling pathway (GO:0042921)2.93169495
100protein localization to chromosome (GO:0034502)2.92495308
101histone-serine phosphorylation (GO:0035404)2.91998598
102regulation of transcription from RNA polymerase I promoter (GO:0006356)2.91637661
103ribonucleoprotein complex biogenesis (GO:0022613)2.91571205
104regulation of translational fidelity (GO:0006450)2.90889310
105spindle checkpoint (GO:0031577)2.88784309
106regulation of nucleobase-containing compound transport (GO:0032239)2.87370416
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87056544
108spindle assembly checkpoint (GO:0071173)2.84665385
109mRNA transport (GO:0051028)2.84308654
110monoubiquitinated protein deubiquitination (GO:0035520)2.83441044
111* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83200020
112* mRNA splicing, via spliceosome (GO:0000398)2.83200020
113* RNA splicing, via transesterification reactions (GO:0000375)2.82319531
114meiotic chromosome segregation (GO:0045132)2.80042803
115kinetochore assembly (GO:0051382)2.78918249
116mitotic spindle checkpoint (GO:0071174)2.77300360
117regulation of mitotic sister chromatid separation (GO:0010965)2.76450952
118regulation of mitotic sister chromatid segregation (GO:0033047)2.76450952
119regulation of sister chromatid segregation (GO:0033045)2.76450952
120mitotic spindle assembly checkpoint (GO:0007094)2.76118381
121negative regulation of chromosome segregation (GO:0051985)2.75260285
122postreplication repair (GO:0006301)2.74969487
123maturation of SSU-rRNA (GO:0030490)2.74107869
124histone exchange (GO:0043486)2.72952469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.33684215
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.34799004
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.89112829
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.76078809
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29181241
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85825982
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.85541646
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69803768
9AR_21909140_ChIP-Seq_LNCAP_Human2.59291084
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.54904205
11* MYC_22102868_ChIP-Seq_BL_Human2.54361576
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41229316
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37749311
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27011409
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21114767
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.15517720
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04027938
18E2F7_22180533_ChIP-Seq_HELA_Human10.6084710
19XRN2_22483619_ChIP-Seq_HELA_Human1.92724085
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.91429378
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84330992
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79020101
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77752512
24* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76633082
25CIITA_25753668_ChIP-Seq_RAJI_Human1.74825803
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.71144581
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68696544
28ELK1_19687146_ChIP-ChIP_HELA_Human1.68306543
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66448077
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66428109
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66138727
32VDR_23849224_ChIP-Seq_CD4+_Human1.65402950
33KDM5A_27292631_Chip-Seq_BREAST_Human1.53638006
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.51319915
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49871456
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49191086
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48050813
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45886641
39TTF2_22483619_ChIP-Seq_HELA_Human1.45580194
40FOXP3_21729870_ChIP-Seq_TREG_Human1.41471374
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41375486
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35144958
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33075240
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32540186
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32128359
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32088161
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.30544141
48DCP1A_22483619_ChIP-Seq_HELA_Human1.26146052
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25868650
50VDR_21846776_ChIP-Seq_THP-1_Human1.25775507
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25093217
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23292496
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22984399
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22058490
55GABP_19822575_ChIP-Seq_HepG2_Human1.21173438
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19705828
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17581282
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15093356
59* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14382703
60* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14096938
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12627034
62CHD1_26751641_Chip-Seq_LNCaP_Human1.11600796
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10942795
64TFEB_21752829_ChIP-Seq_HELA_Human1.10709982
65* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10261203
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08366857
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.07159812
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06228372
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06137665
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05873731
71* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02917596
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02201740
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00822349
74* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99202000
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99088296
76NANOG_21062744_ChIP-ChIP_HESCs_Human0.98636958
77NANOG_16153702_ChIP-ChIP_HESCs_Human0.98568663
78ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98392054
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98222320
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96688906
81* MYB_26560356_Chip-Seq_TH1_Human0.96378732
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.95835922
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95532631
84PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95365473
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94829407
86UTX_26944678_Chip-Seq_JUKART_Human0.94687220
87CLOCK_20551151_ChIP-Seq_293T_Human0.93808788
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93701305
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93456097
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93134029
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92991645
92MYB_26560356_Chip-Seq_TH2_Human0.92673358
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92450604
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92389137
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92078014
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91174881
97* MAF_26560356_Chip-Seq_TH1_Human0.90800346
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89206559
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87815116
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87327123
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87323232
102THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86995373
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86904689
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86442650
105MYC_18940864_ChIP-ChIP_HL60_Human0.86075760
106* SPI1_23547873_ChIP-Seq_NB4_Human0.86015685
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85514768
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84729787
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84693164
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82508205
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81590680
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81590680
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81590680
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80488660
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.80136519
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.78713040
117* NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78404107
118* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77434558
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76386646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.58149962
2MP0003693_abnormal_embryo_hatching3.35866374
3MP0003111_abnormal_nucleus_morphology3.25410263
4MP0004957_abnormal_blastocyst_morpholog3.11214006
5MP0008057_abnormal_DNA_replication3.11006949
6MP0010352_gastrointestinal_tract_polyps3.01726700
7MP0003077_abnormal_cell_cycle2.98425247
8MP0002396_abnormal_hematopoietic_system2.52512849
9MP0003705_abnormal_hypodermis_morpholog2.38507373
10MP0008007_abnormal_cellular_replicative2.35135063
11MP0010307_abnormal_tumor_latency2.28834766
12MP0005076_abnormal_cell_differentiation2.23551595
13MP0003123_paternal_imprinting2.20886558
14MP0009697_abnormal_copulation2.15587706
15MP0001730_embryonic_growth_arrest2.08444511
16MP0000350_abnormal_cell_proliferation2.07113874
17MP0008058_abnormal_DNA_repair1.99829409
18MP0004808_abnormal_hematopoietic_stem1.97161212
19MP0001672_abnormal_embryogenesis/_devel1.78875693
20MP0005380_embryogenesis_phenotype1.78875693
21MP0009053_abnormal_anal_canal1.78642239
22MP0004197_abnormal_fetal_growth/weight/1.78145603
23MP0008932_abnormal_embryonic_tissue1.75952882
24MP0003984_embryonic_growth_retardation1.73776387
25MP0002088_abnormal_embryonic_growth/wei1.72144808
26MP0003567_abnormal_fetal_cardiomyocyte1.70837208
27MP0001697_abnormal_embryo_size1.66568373
28MP0000537_abnormal_urethra_morphology1.65558071
29MP0002084_abnormal_developmental_patter1.62194634
30MP0002086_abnormal_extraembryonic_tissu1.60404797
31MP0003121_genomic_imprinting1.59649881
32MP0000569_abnormal_digit_pigmentation1.59415273
33MP0010030_abnormal_orbit_morphology1.54555594
34MP0004185_abnormal_adipocyte_glucose1.52888959
35MP0002085_abnormal_embryonic_tissue1.51820020
36MP0006054_spinal_hemorrhage1.48057568
37MP0002080_prenatal_lethality1.42728262
38MP0002796_impaired_skin_barrier1.42431424
39MP0000733_abnormal_muscle_development1.41371440
40MP0003718_maternal_effect1.40610452
41MP0000490_abnormal_crypts_of1.40061804
42MP0010234_abnormal_vibrissa_follicle1.38993057
43MP0003300_gastrointestinal_ulcer1.32707108
44MP0008877_abnormal_DNA_methylation1.27417784
45MP0001293_anophthalmia1.27084413
46MP0002166_altered_tumor_susceptibility1.25499163
47MP0009278_abnormal_bone_marrow1.21724642
48MP0005397_hematopoietic_system_phenotyp1.20029021
49MP0001545_abnormal_hematopoietic_system1.20029021
50MP0000428_abnormal_craniofacial_morphol1.19581948
51MP0003566_abnormal_cell_adhesion1.18943525
52MP0003890_abnormal_embryonic-extraembry1.18179018
53MP0002877_abnormal_melanocyte_morpholog1.16563545
54MP0000703_abnormal_thymus_morphology1.16405893
55MP0005501_abnormal_skin_physiology1.15111324
56MP0002019_abnormal_tumor_incidence1.13004847
57MP0008438_abnormal_cutaneous_collagen1.12143124
58MP0000579_abnormal_nail_morphology1.11121999
59MP0002009_preneoplasia1.10942367
60MP0000313_abnormal_cell_death1.08882982
61MP0001849_ear_inflammation1.07838690
62MP0003763_abnormal_thymus_physiology1.07665046
63MP0003937_abnormal_limbs/digits/tail_de1.07524152
64MP0004233_abnormal_muscle_weight1.06325067
65MP0003786_premature_aging1.05528832
66MP0009703_decreased_birth_body1.05497388
67MP0009672_abnormal_birth_weight1.04582024
68MP0002006_tumorigenesis1.04027453
69MP0002092_abnormal_eye_morphology1.02958735
70MP0000762_abnormal_tongue_morphology1.01440774
71MP0002060_abnormal_skin_morphology1.01391973
72MP0003935_abnormal_craniofacial_develop1.01289379
73MP0003221_abnormal_cardiomyocyte_apopto0.99782178
74MP0001915_intracranial_hemorrhage0.97194871
75MP0002398_abnormal_bone_marrow0.96565397
76MP0003115_abnormal_respiratory_system0.94823377
77MP0005023_abnormal_wound_healing0.93106919
78MP0000432_abnormal_head_morphology0.92596654
79MP0002925_abnormal_cardiovascular_devel0.92060435
80MP0001286_abnormal_eye_development0.86589731
81MP0006292_abnormal_olfactory_placode0.85230213
82MP0005275_abnormal_skin_tensile0.85154278
83MP0005384_cellular_phenotype0.83916322
84MP0001661_extended_life_span0.83527261
85MP0010678_abnormal_skin_adnexa0.82472098
86MP0002722_abnormal_immune_system0.82186906
87MP0000383_abnormal_hair_follicle0.82163877
88MP0002697_abnormal_eye_size0.81251502
89MP0003787_abnormal_imprinting0.81203230
90MP0004264_abnormal_extraembryonic_tissu0.80846375
91MP0003755_abnormal_palate_morphology0.80276193
92MP0000358_abnormal_cell_content/0.79981760
93MP0002111_abnormal_tail_morphology0.79419834
94MP0003448_altered_tumor_morphology0.79368957
95MP0003119_abnormal_digestive_system0.79068125
96MP0001216_abnormal_epidermal_layer0.78010869
97MP0003385_abnormal_body_wall0.77627374
98MP0002233_abnormal_nose_morphology0.77551613
99MP0001188_hyperpigmentation0.75969657
100MP0005503_abnormal_tendon_morphology0.75544214
101MP0000858_altered_metastatic_potential0.74712769
102MP0009333_abnormal_splenocyte_physiolog0.74081980
103MP0003941_abnormal_skin_development0.73577520
104MP0001881_abnormal_mammary_gland0.72513805
105MP0003861_abnormal_nervous_system0.72285836
106MP0002210_abnormal_sex_determination0.71415237
107MP0003943_abnormal_hepatobiliary_system0.70988200
108MP0004782_abnormal_surfactant_physiolog0.70471796
109MP0000627_abnormal_mammary_gland0.70176966
110MP0000689_abnormal_spleen_morphology0.70046151
111MP0000377_abnormal_hair_follicle0.69885030
112MP0005367_renal/urinary_system_phenotyp0.69481466
113MP0000516_abnormal_urinary_system0.69481466
114MP0000266_abnormal_heart_morphology0.69458717
115MP0002938_white_spotting0.67870459
116MP0003315_abnormal_perineum_morphology0.67476962
117MP0008770_decreased_survivor_rate0.67456733
118MP0003942_abnormal_urinary_system0.66989663
119MP0005621_abnormal_cell_physiology0.66980813
120MP0003453_abnormal_keratinocyte_physiol0.66604074
121MP0002932_abnormal_joint_morphology0.66542363
122MP0005623_abnormal_meninges_morphology0.66488429
123MP0004272_abnormal_basement_membrane0.65665703
124MP0002081_perinatal_lethality0.63826636
125MP0005408_hypopigmentation0.63776058
126MP0001299_abnormal_eye_distance/0.62556218
127MP0002114_abnormal_axial_skeleton0.62545741
128MP0003950_abnormal_plasma_membrane0.60956605
129MP0001340_abnormal_eyelid_morphology0.60608343

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.41477430
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.41477430
3Volvulus (HP:0002580)3.20659703
4Nephroblastoma (Wilms tumor) (HP:0002667)3.10097859
5Colon cancer (HP:0003003)3.03728667
6Embryonal renal neoplasm (HP:0011794)3.00794798
7Multiple enchondromatosis (HP:0005701)2.92584451
8Birth length less than 3rd percentile (HP:0003561)2.90294723
9Selective tooth agenesis (HP:0001592)2.86269877
10Deviation of the thumb (HP:0009603)2.77858034
11Abnormality of the fingertips (HP:0001211)2.75798364
12Proximal placement of thumb (HP:0009623)2.71876027
13Ependymoma (HP:0002888)2.69138217
14Increased nuchal translucency (HP:0010880)2.66718707
15Cortical dysplasia (HP:0002539)2.63685459
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.62909028
17Increased density of long bones (HP:0006392)2.51908585
18Syringomyelia (HP:0003396)2.51846624
19Spinal cord lesions (HP:0100561)2.51846624
20Abnormality of the 4th metacarpal (HP:0010012)2.51309860
21Medulloblastoma (HP:0002885)2.50983279
22Abnormal lung lobation (HP:0002101)2.47541902
23Small intestinal stenosis (HP:0012848)2.43365791
24Duodenal stenosis (HP:0100867)2.43365791
25Subacute progressive viral hepatitis (HP:0006572)2.40363237
26Missing ribs (HP:0000921)2.33120336
27Abnormality of the astrocytes (HP:0100707)2.28216094
28Astrocytoma (HP:0009592)2.28216094
29Long eyelashes (HP:0000527)2.27926710
30Progressive external ophthalmoplegia (HP:0000590)2.25371994
31Biliary tract neoplasm (HP:0100574)2.23538759
32Abnormal number of incisors (HP:0011064)2.21741103
33High pitched voice (HP:0001620)2.20915489
34Abnormality of the carotid arteries (HP:0005344)2.20743729
35Pelvic girdle muscle weakness (HP:0003749)2.16710369
36Patellar aplasia (HP:0006443)2.16237845
37Cutaneous melanoma (HP:0012056)2.15316431
38Abnormality of chromosome stability (HP:0003220)2.14025140
39Prominent nose (HP:0000448)2.13774275
40Atresia of the external auditory canal (HP:0000413)2.13711115
41Overlapping toe (HP:0001845)2.12865118
42Choanal atresia (HP:0000453)2.12306925
43Progressive muscle weakness (HP:0003323)2.11614204
44Chromsome breakage (HP:0040012)2.10832298
45Gastrointestinal carcinoma (HP:0002672)2.09546772
46Malignant gastrointestinal tract tumors (HP:0006749)2.09546772
47Asymmetry of the thorax (HP:0001555)2.09440949
48Shallow orbits (HP:0000586)2.08349748
49Rectal prolapse (HP:0002035)2.08111140
50Ectopic kidney (HP:0000086)2.05876834
51Deep philtrum (HP:0002002)2.05292889
52Aplasia/Hypoplasia of the patella (HP:0006498)2.05153662
53Cutis marmorata (HP:0000965)2.04791639
54Absent radius (HP:0003974)2.04718312
55Glioma (HP:0009733)2.04658327
56Acute myeloid leukemia (HP:0004808)2.04121340
57Renal duplication (HP:0000075)2.03828848
58Abnormality of the duodenum (HP:0002246)2.03191281
59Basal cell carcinoma (HP:0002671)2.02828373
60Microglossia (HP:0000171)2.02391370
61Abnormality of the umbilical cord (HP:0010881)1.97718521
62Myelodysplasia (HP:0002863)1.97598702
63Ankle contracture (HP:0006466)1.97206075
64Microvesicular hepatic steatosis (HP:0001414)1.95996399
65Termporal pattern (HP:0011008)1.94872084
66Insidious onset (HP:0003587)1.94872084
67Rhabdomyosarcoma (HP:0002859)1.94518455
68Facial hemangioma (HP:0000329)1.93808237
69Hyperacusis (HP:0010780)1.93016032
70Protrusio acetabuli (HP:0003179)1.92875183
71Osteolytic defects of the hand bones (HP:0009699)1.92696392
72Osteolytic defects of the phalanges of the hand (HP:0009771)1.92696392
73Spastic diplegia (HP:0001264)1.92473176
74Thrombocytosis (HP:0001894)1.91050117
75Absent forearm bone (HP:0003953)1.89949859
76Aplasia involving forearm bones (HP:0009822)1.89949859
77Degeneration of anterior horn cells (HP:0002398)1.89769320
78Abnormality of the anterior horn cell (HP:0006802)1.89769320
79Reticulocytopenia (HP:0001896)1.88748972
80High anterior hairline (HP:0009890)1.88748609
81Neoplasm of the colon (HP:0100273)1.88584748
82Abnormality of the calcaneus (HP:0008364)1.88181392
83Embryonal neoplasm (HP:0002898)1.86678804
84Abnormality of the labia minora (HP:0012880)1.86660160
85Ankyloglossia (HP:0010296)1.84111846
86Absent frontal sinuses (HP:0002688)1.83266013
87Breast hypoplasia (HP:0003187)1.82126496
88Shoulder girdle muscle weakness (HP:0003547)1.80589398
89Urethral obstruction (HP:0000796)1.80182621
90Septate vagina (HP:0001153)1.78959937
91Trigonocephaly (HP:0000243)1.78742289
92Neoplasm of the pancreas (HP:0002894)1.77439663
93Bowel diverticulosis (HP:0005222)1.77057450
94Abnormality of chromosome segregation (HP:0002916)1.76770173
95Abnormal umbilical cord blood vessels (HP:0011403)1.75284217
96Single umbilical artery (HP:0001195)1.75284217
97Abnormality of the fetal cardiovascular system (HP:0010948)1.75284217
98Broad thumb (HP:0011304)1.74489250
99Skin tags (HP:0010609)1.74375641
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74359862
101Uterine neoplasm (HP:0010784)1.74248669
102Abnormality of the musculature of the pelvis (HP:0001469)1.73260662
103Abnormality of the hip-girdle musculature (HP:0001445)1.73260662
104Uterine leiomyosarcoma (HP:0002891)1.72959388
105Leiomyosarcoma (HP:0100243)1.72959388
106Trismus (HP:0000211)1.72569719
107Horseshoe kidney (HP:0000085)1.72450548
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71929554
109Abnormality of glycolysis (HP:0004366)1.70907706
110Facial cleft (HP:0002006)1.70876609
111Cafe-au-lait spot (HP:0000957)1.70008142
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69720379
113Neoplasm of the oral cavity (HP:0100649)1.69631538
114Overriding aorta (HP:0002623)1.69476269
115Sandal gap (HP:0001852)1.68736185
116Slender long bone (HP:0003100)1.68712251
117Meckel diverticulum (HP:0002245)1.68676466
118Skull defect (HP:0001362)1.68181725
119Short middle phalanx of the 5th finger (HP:0004220)1.67998128
120Impulsivity (HP:0100710)1.67843295
121Broad palm (HP:0001169)1.67394824
122Bicuspid aortic valve (HP:0001647)1.67034506
123Neoplasm of striated muscle (HP:0009728)1.66897716
124Papillary thyroid carcinoma (HP:0002895)1.66859271
125Agnosia (HP:0010524)1.66510855
126Abnormality of the peritoneum (HP:0002585)1.66251901
127Sloping forehead (HP:0000340)1.66033269
128Sparse lateral eyebrow (HP:0005338)1.66020375
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.65951252
130Neoplasm of the small intestine (HP:0100833)1.65941183
131Renovascular hypertension (HP:0100817)1.63583538
132Transitional cell carcinoma of the bladder (HP:0006740)1.63145205
133Arteriovenous malformation (HP:0100026)1.62764017
134Blepharitis (HP:0000498)1.62529487
135Neuroectodermal neoplasm (HP:0030061)1.61732707
136Neuroepithelial neoplasm (HP:0030063)1.61732707
137Nervous tissue neoplasm (HP:0030060)1.61732707
138Macrocytic anemia (HP:0001972)1.60850424
139Abnormalities of placenta or umbilical cord (HP:0001194)1.59799333
140Low anterior hairline (HP:0000294)1.59496104
141Neuroblastoma (HP:0003006)1.59467541
142Primitive neuroectodermal tumor (HP:0030065)1.59467541
143Neuroblastic tumors (HP:0004376)1.59467541
144Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59467541
145Triphalangeal thumb (HP:0001199)1.59398508
146Squamous cell carcinoma (HP:0002860)1.58893044
147Ovarian neoplasm (HP:0100615)1.58624977
148Supernumerary ribs (HP:0005815)1.58479235
149Hematochezia (HP:0002573)1.58400561
150Heterotopia (HP:0002282)1.57670725
151Abnormality of the preputium (HP:0100587)1.56949606
152Deviation of the hallux (HP:0010051)1.56567803
153Fibrous tissue neoplasm (HP:0012316)1.56255596
154Preauricular skin tag (HP:0000384)1.56154524
155Abnormality of the ileum (HP:0001549)1.56143088
156Cerebral aneurysm (HP:0004944)1.55250865
157Hallux valgus (HP:0001822)1.55244839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.06502964
2CDK123.13075066
3WEE12.76437876
4NEK22.66491393
5MKNK12.64815540
6EEF2K2.54745922
7SRPK12.43405972
8PBK2.37231317
9PKN22.31923951
10MKNK22.21368405
11TSSK62.08981432
12RPS6KA42.03539779
13LATS11.97981604
14MAP3K101.92062231
15BUB11.83034903
16CDK61.79367541
17TTK1.78296156
18EIF2AK11.78269686
19SMG11.77822752
20RPS6KB21.75804300
21TAF11.74371436
22PNCK1.72654695
23NEK11.71258041
24BRD41.70942072
25ATR1.70482971
26PLK31.69827608
27CDK41.68130991
28SCYL21.67284605
29PASK1.65530536
30MST41.59306293
31STK31.54345902
32AURKB1.54318529
33ALK1.52471007
34TGFBR11.51609273
35STK101.50409752
36VRK21.49548504
37PLK11.45095958
38BRSK21.43718788
39TRIB31.43174519
40TTN1.40117997
41CHEK11.35888293
42MAP3K81.35681436
43CDK71.34718608
44DYRK31.30922092
45CHEK21.27364580
46ZAK1.18754283
47ACVR1B1.15598303
48ATM1.11552842
49STK41.07764427
50PLK41.05847672
51PAK41.05725313
52LRRK21.05612136
53ERBB31.05243214
54MST1R1.04090816
55TRIM281.03774866
56NME21.01378514
57MTOR0.98579477
58CDK20.96559907
59PIM10.94950585
60PTK60.93587006
61PAK20.92157138
62PDGFRA0.89549238
63MAP4K10.85881853
64FRK0.83835286
65FGFR30.81461407
66TLK10.80997696
67NEK90.80903816
68ERBB40.76793016
69CAMK1G0.75404305
70NME10.74674875
71TNIK0.73725588
72CDK10.73654281
73ICK0.73292124
74EIF2AK30.72222558
75EPHA20.72186654
76CDK80.69233366
77MELK0.66541075
78CDK90.66130223
79FLT30.63346087
80CHUK0.63311320
81MAP2K30.63222759
82STK38L0.63203340
83LATS20.62943945
84DMPK0.62729715
85VRK10.61405211
86BCR0.59857274
87BRSK10.56049906
88JAK30.55633679
89PRKDC0.54336748
90CDK30.51979098
91MET0.51719109
92CSNK2A20.50561421
93FGFR20.50343106
94CLK10.49644704
95CSNK1D0.49492156
96PDGFRB0.49088072
97CAMK1D0.48005134
98* FGFR10.46990658
99AURKA0.46837807
100MAPK140.46356264
101STK160.45952304
102RIPK10.45815309
103DDR20.44284358
104CSNK1E0.43117700
105BRAF0.41188150
106YES10.40376543
107RPS6KA50.40347875
108STK240.39450330
109RPS6KB10.39060314
110ILK0.38925032
111AKT20.37610371
112TESK20.37346859
113CCNB10.36872586
114EIF2AK20.36836726
115MAP3K140.36638328
116CSNK2A10.35725924
117AKT10.35226438
118NUAK10.35181621
119TAOK20.34231873
120BMX0.33271461
121MAP3K90.33053825
122BTK0.32749811
123RPS6KA10.31327916
124NEK60.28208244
125CDK180.27514403
126GSK3B0.26268522
127IRAK30.26237551
128CDK11A0.25961872
129KSR10.24235202

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.60631063
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12088851
3Mismatch repair_Homo sapiens_hsa034303.08658828
4Spliceosome_Homo sapiens_hsa030403.00567751
5RNA transport_Homo sapiens_hsa030132.98694385
6Cell cycle_Homo sapiens_hsa041102.84630918
7One carbon pool by folate_Homo sapiens_hsa006702.31978971
8mRNA surveillance pathway_Homo sapiens_hsa030152.27915757
9Base excision repair_Homo sapiens_hsa034102.24862564
10Nucleotide excision repair_Homo sapiens_hsa034202.10831836
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99818662
12Homologous recombination_Homo sapiens_hsa034401.86936291
13Non-homologous end-joining_Homo sapiens_hsa034501.75072619
14p53 signaling pathway_Homo sapiens_hsa041151.71739392
15RNA degradation_Homo sapiens_hsa030181.67181424
16Fanconi anemia pathway_Homo sapiens_hsa034601.61629481
17MicroRNAs in cancer_Homo sapiens_hsa052061.56885121
18Systemic lupus erythematosus_Homo sapiens_hsa053221.53371486
19Viral carcinogenesis_Homo sapiens_hsa052031.51721552
20RNA polymerase_Homo sapiens_hsa030201.51144711
21Protein export_Homo sapiens_hsa030601.49983520
22Ribosome_Homo sapiens_hsa030101.49510995
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48668790
24Small cell lung cancer_Homo sapiens_hsa052221.47839447
25Chronic myeloid leukemia_Homo sapiens_hsa052201.46040047
26Antigen processing and presentation_Homo sapiens_hsa046121.35334839
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.35070178
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31141243
29HTLV-I infection_Homo sapiens_hsa051661.31028356
30Herpes simplex infection_Homo sapiens_hsa051681.28398290
31Epstein-Barr virus infection_Homo sapiens_hsa051691.28387221
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22042234
33Viral myocarditis_Homo sapiens_hsa054161.21971841
34Biosynthesis of amino acids_Homo sapiens_hsa012301.20304721
35Pyrimidine metabolism_Homo sapiens_hsa002401.19181137
36Adherens junction_Homo sapiens_hsa045201.18033515
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17323421
38Colorectal cancer_Homo sapiens_hsa052101.15549830
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15508812
40Thyroid cancer_Homo sapiens_hsa052161.12486190
41Basal transcription factors_Homo sapiens_hsa030221.11433642
42TGF-beta signaling pathway_Homo sapiens_hsa043501.10681755
43mTOR signaling pathway_Homo sapiens_hsa041501.06234780
44Oocyte meiosis_Homo sapiens_hsa041141.00535228
45Hepatitis B_Homo sapiens_hsa051610.99993338
46Hippo signaling pathway_Homo sapiens_hsa043900.98693865
47Vitamin B6 metabolism_Homo sapiens_hsa007500.97708088
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96235125
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95808474
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95222827
51Proteasome_Homo sapiens_hsa030500.94557609
52Proteoglycans in cancer_Homo sapiens_hsa052050.93233294
53Pyruvate metabolism_Homo sapiens_hsa006200.93077394
54Pancreatic cancer_Homo sapiens_hsa052120.91807168
55Prostate cancer_Homo sapiens_hsa052150.90859556
56Basal cell carcinoma_Homo sapiens_hsa052170.89866067
57Measles_Homo sapiens_hsa051620.88141310
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.86481559
59Carbon metabolism_Homo sapiens_hsa012000.86295697
60Endometrial cancer_Homo sapiens_hsa052130.86017214
61Non-small cell lung cancer_Homo sapiens_hsa052230.84985945
62Legionellosis_Homo sapiens_hsa051340.84138904
63Acute myeloid leukemia_Homo sapiens_hsa052210.83406293
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81433450
65Lysine degradation_Homo sapiens_hsa003100.78797105
66Bladder cancer_Homo sapiens_hsa052190.77854734
67Apoptosis_Homo sapiens_hsa042100.77632384
68Steroid biosynthesis_Homo sapiens_hsa001000.76127973
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.75246570
70Focal adhesion_Homo sapiens_hsa045100.73545942
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72620379
72Primary immunodeficiency_Homo sapiens_hsa053400.70499083
73B cell receptor signaling pathway_Homo sapiens_hsa046620.70287182
74Pathways in cancer_Homo sapiens_hsa052000.70211921
75Toxoplasmosis_Homo sapiens_hsa051450.69707328
76Shigellosis_Homo sapiens_hsa051310.69330893
77Leishmaniasis_Homo sapiens_hsa051400.68170928
78T cell receptor signaling pathway_Homo sapiens_hsa046600.67827873
79Pentose phosphate pathway_Homo sapiens_hsa000300.67524289
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.67316764
81Notch signaling pathway_Homo sapiens_hsa043300.66663083
82HIF-1 signaling pathway_Homo sapiens_hsa040660.64840912
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64746874
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64687360
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64465256
86Influenza A_Homo sapiens_hsa051640.63956456
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61970250
88Alcoholism_Homo sapiens_hsa050340.61334257
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59591196
90FoxO signaling pathway_Homo sapiens_hsa040680.58849967
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.57806556
92Glioma_Homo sapiens_hsa052140.57161923
93ECM-receptor interaction_Homo sapiens_hsa045120.56072650
94Selenocompound metabolism_Homo sapiens_hsa004500.56068930
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55334651
96Melanoma_Homo sapiens_hsa052180.54163462
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52670351
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.52380132
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50568558
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50566842
101Wnt signaling pathway_Homo sapiens_hsa043100.50440049
102Hedgehog signaling pathway_Homo sapiens_hsa043400.50161569
103TNF signaling pathway_Homo sapiens_hsa046680.49391052
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49006674
105Osteoclast differentiation_Homo sapiens_hsa043800.48026036
106Hematopoietic cell lineage_Homo sapiens_hsa046400.47486651
107Purine metabolism_Homo sapiens_hsa002300.46594568
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46242648
109Renal cell carcinoma_Homo sapiens_hsa052110.45890001
110Platelet activation_Homo sapiens_hsa046110.45425715
111Asthma_Homo sapiens_hsa053100.44710106
112Propanoate metabolism_Homo sapiens_hsa006400.44451487
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44068238
114Prolactin signaling pathway_Homo sapiens_hsa049170.43624325
115Tight junction_Homo sapiens_hsa045300.42936524
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41713054
117N-Glycan biosynthesis_Homo sapiens_hsa005100.41155624
118Folate biosynthesis_Homo sapiens_hsa007900.38489726
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33219109
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29585716
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28071291
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25539481
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25508844
124Huntingtons disease_Homo sapiens_hsa050160.20909079
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20063055
126Glutathione metabolism_Homo sapiens_hsa004800.19396699
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18713705
128ErbB signaling pathway_Homo sapiens_hsa040120.17891261
129Insulin signaling pathway_Homo sapiens_hsa049100.09371094

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