SYNDIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)8.68050859
2* presynaptic membrane organization (GO:0097090)7.89522124
3regulation of short-term neuronal synaptic plasticity (GO:0048172)7.28426842
4ionotropic glutamate receptor signaling pathway (GO:0035235)6.01618049
5negative regulation of synaptic transmission, GABAergic (GO:0032229)5.61744768
6synaptic transmission, glutamatergic (GO:0035249)5.52849982
7glutamate secretion (GO:0014047)5.51116130
8vocalization behavior (GO:0071625)5.49293980
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38851632
10synaptic vesicle exocytosis (GO:0016079)5.31287059
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30165325
12glutamate receptor signaling pathway (GO:0007215)5.20140009
13axon ensheathment in central nervous system (GO:0032291)5.16078914
14central nervous system myelination (GO:0022010)5.16078914
15neuron-neuron synaptic transmission (GO:0007270)5.13821078
16synaptic vesicle docking involved in exocytosis (GO:0016081)5.07599189
17regulation of synaptic vesicle exocytosis (GO:2000300)4.81112462
18neurotransmitter-gated ion channel clustering (GO:0072578)4.74664602
19regulation of glutamate receptor signaling pathway (GO:1900449)4.74197160
20neuronal action potential propagation (GO:0019227)4.68503522
21protein localization to synapse (GO:0035418)4.68080915
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.62814204
23cerebellar granule cell differentiation (GO:0021707)4.54564626
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.54441833
25neuron cell-cell adhesion (GO:0007158)4.52281913
26locomotory exploration behavior (GO:0035641)4.44411098
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.43812949
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42922009
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.42165350
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40197061
31synaptic vesicle maturation (GO:0016188)4.38374446
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.34010301
33positive regulation of synapse maturation (GO:0090129)4.33866244
34neurotransmitter secretion (GO:0007269)4.30949691
35regulation of synaptic vesicle transport (GO:1902803)4.25235345
36sodium ion export (GO:0071436)4.22101134
37neuronal ion channel clustering (GO:0045161)4.17208505
38regulation of postsynaptic membrane potential (GO:0060078)4.15450309
39regulation of neuronal synaptic plasticity (GO:0048168)4.09877943
40membrane assembly (GO:0071709)4.06386597
41L-amino acid import (GO:0043092)3.92702214
42potassium ion homeostasis (GO:0055075)3.86225497
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85333335
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80367057
45behavioral fear response (GO:0001662)3.80000077
46behavioral defense response (GO:0002209)3.80000077
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71789206
48long-term synaptic potentiation (GO:0060291)3.69694650
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.69070456
50regulation of synapse structural plasticity (GO:0051823)3.65429187
51neuron recognition (GO:0008038)3.64034025
52behavioral response to cocaine (GO:0048148)3.62386373
53positive regulation of membrane potential (GO:0045838)3.62174482
54postsynaptic membrane organization (GO:0001941)3.61879317
55regulation of synaptic plasticity (GO:0048167)3.60580875
56fear response (GO:0042596)3.58918025
57* positive regulation of synapse assembly (GO:0051965)3.57605952
58long-term memory (GO:0007616)3.57546573
59regulation of female receptivity (GO:0045924)3.55604853
60gamma-aminobutyric acid transport (GO:0015812)3.53271356
61exploration behavior (GO:0035640)3.52264135
62detection of calcium ion (GO:0005513)3.51004665
63regulation of synapse maturation (GO:0090128)3.49395837
64female mating behavior (GO:0060180)3.48158536
65cerebellar Purkinje cell differentiation (GO:0021702)3.47291356
66membrane hyperpolarization (GO:0060081)3.46831477
67positive regulation of neurotransmitter secretion (GO:0001956)3.46549950
68negative regulation of dendrite morphogenesis (GO:0050774)3.46503726
69neurotransmitter transport (GO:0006836)3.45919892
70regulation of neurotransmitter secretion (GO:0046928)3.42696971
71regulation of glutamate secretion (GO:0014048)3.41441005
72adult walking behavior (GO:0007628)3.41012840
73cell communication by electrical coupling (GO:0010644)3.40409638
74layer formation in cerebral cortex (GO:0021819)3.40367377
75response to histamine (GO:0034776)3.39765568
76potassium ion import (GO:0010107)3.38410275
77positive regulation of dendritic spine development (GO:0060999)3.36857853
78amino acid import (GO:0043090)3.36467000
79positive regulation of dendrite morphogenesis (GO:0050775)3.36020343
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.35698719
81transmission of nerve impulse (GO:0019226)3.35116184
82membrane depolarization (GO:0051899)3.33206931
83auditory behavior (GO:0031223)3.32831392
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32555145
85synaptic vesicle endocytosis (GO:0048488)3.32131116
86glycosphingolipid biosynthetic process (GO:0006688)3.32125068
87regulation of synaptic transmission, GABAergic (GO:0032228)3.31028954
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27996199
89positive regulation of neurotransmitter transport (GO:0051590)3.23382322
90mechanosensory behavior (GO:0007638)3.22960667
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21565370
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20342645
93regulation of dendritic spine morphogenesis (GO:0061001)3.19464632
94negative regulation of dendrite development (GO:2000171)3.17914222
95positive regulation of synaptic transmission (GO:0050806)3.17764932
96regulation of neurotransmitter levels (GO:0001505)3.17360017
97regulation of neurotransmitter transport (GO:0051588)3.16666905
98cellular potassium ion homeostasis (GO:0030007)3.15070870
99cGMP metabolic process (GO:0046068)3.14500502
100regulation of neurotransmitter uptake (GO:0051580)3.14449172
101regulation of dendritic spine development (GO:0060998)3.12585714
102cellular sodium ion homeostasis (GO:0006883)3.11203845
103dendritic spine morphogenesis (GO:0060997)3.08460025
104membrane depolarization during action potential (GO:0086010)3.08397025
105prepulse inhibition (GO:0060134)3.08347965
106negative regulation of amino acid transport (GO:0051956)3.07194262
107neurotransmitter uptake (GO:0001504)3.06950541
108synaptic transmission (GO:0007268)3.06571131
109acidic amino acid transport (GO:0015800)3.03578432
110startle response (GO:0001964)3.03185066
111C4-dicarboxylate transport (GO:0015740)3.03047896
112adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.02812268
113regulation of synaptic transmission (GO:0050804)3.02065329
114positive regulation of dendritic spine morphogenesis (GO:0061003)3.01287960
115astrocyte development (GO:0014002)3.00929907
116learning (GO:0007612)3.00825328
117axonal fasciculation (GO:0007413)2.98579612
118activation of protein kinase A activity (GO:0034199)2.98508515
119response to auditory stimulus (GO:0010996)2.97852953
120negative regulation of synaptic transmission (GO:0050805)2.97715219
121positive regulation of dendrite development (GO:1900006)2.97383057
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97098927
123regulation of vesicle fusion (GO:0031338)2.96712893
124long term synaptic depression (GO:0060292)2.96502281
125striatum development (GO:0021756)2.95237756
126righting reflex (GO:0060013)2.94856967
127neuromuscular process controlling balance (GO:0050885)2.92093353
128proline transport (GO:0015824)2.91289704
129cell differentiation in hindbrain (GO:0021533)2.91265111
130regulation of voltage-gated calcium channel activity (GO:1901385)2.90838861
131dendrite morphogenesis (GO:0048813)2.90379530
132regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.88536227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84873777
2GBX2_23144817_ChIP-Seq_PC3_Human4.61259181
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.28077751
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20100711
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06372989
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72887022
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72887022
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69600345
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65784229
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.65764854
11REST_21632747_ChIP-Seq_MESCs_Mouse2.63315139
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62489355
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.47799651
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.47386951
15TAF15_26573619_Chip-Seq_HEK293_Human2.39984166
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39867587
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35995156
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.32218775
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31400065
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19677429
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19134267
22DROSHA_22980978_ChIP-Seq_HELA_Human2.18027105
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.15111125
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14249484
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.12088832
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09825398
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93294285
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92687375
29SMAD4_21799915_ChIP-Seq_A2780_Human1.87995830
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83936561
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.80624976
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79423856
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72706244
34P300_19829295_ChIP-Seq_ESCs_Human1.69315446
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66937319
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62811410
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62012273
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59194865
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51377209
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51145283
41VDR_22108803_ChIP-Seq_LS180_Human1.49677899
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.49047787
43FUS_26573619_Chip-Seq_HEK293_Human1.48927047
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41587666
45AR_21572438_ChIP-Seq_LNCaP_Human1.40295220
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40148597
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39563674
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.39329674
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38215619
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37029290
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36789370
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.36130970
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36127184
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32953733
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31517427
56RNF2_27304074_Chip-Seq_NSC_Mouse1.30470772
57AR_25329375_ChIP-Seq_VCAP_Human1.28438128
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.27292988
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27002380
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.23977324
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22539485
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.22473541
63STAT3_23295773_ChIP-Seq_U87_Human1.22281892
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22109882
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21566093
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.21343194
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20302125
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19585485
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19200803
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.18973471
71TCF4_23295773_ChIP-Seq_U87_Human1.18572630
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18365600
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17546644
74AR_19668381_ChIP-Seq_PC3_Human1.12351555
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11624388
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11617775
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09868839
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.08248194
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06857626
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06789801
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05837605
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.05422598
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05051464
84ER_23166858_ChIP-Seq_MCF-7_Human1.03075639
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02998530
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02798575
87AHR_22903824_ChIP-Seq_MCF-7_Human1.02187104
88RUNX2_22187159_ChIP-Seq_PCA_Human1.01621432
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01401341
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01401341
91ZNF274_21170338_ChIP-Seq_K562_Hela1.00345482
92RXR_22108803_ChIP-Seq_LS180_Human1.00057639
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99728978
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99692526
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99146015
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.98812630
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.97893987
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96916159
99RING1B_27294783_Chip-Seq_NPCs_Mouse0.96355009
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96086198
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95390405
102BCAT_22108803_ChIP-Seq_LS180_Human0.94283568
103TP53_18474530_ChIP-ChIP_U2OS_Human0.94066664
104KDM2B_26808549_Chip-Seq_REH_Human0.93312942
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92930773
106P53_22387025_ChIP-Seq_ESCs_Mouse0.92579157
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91068211
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90615075
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90110752
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89710015
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.89096237
112SOX9_26525672_Chip-Seq_HEART_Mouse0.88929730
113IGF1R_20145208_ChIP-Seq_DFB_Human0.88815103
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88209206
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87561469
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87250632
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.86551351
118JUN_21703547_ChIP-Seq_K562_Human0.86100864
119CBP_20019798_ChIP-Seq_JUKART_Human0.86064175
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86064175
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85953876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90665071
2MP0003880_abnormal_central_pattern5.02148411
3MP0003635_abnormal_synaptic_transmissio4.20902675
4MP0009745_abnormal_behavioral_response3.79336616
5MP0009046_muscle_twitch3.47990340
6MP0002063_abnormal_learning/memory/cond3.35551527
7MP0002064_seizures3.34489539
8MP0004270_analgesia3.17001871
9MP0001968_abnormal_touch/_nociception3.06124404
10MP0002572_abnormal_emotion/affect_behav2.92967503
11MP0002272_abnormal_nervous_system2.75021501
12MP0005171_absent_coat_pigmentation2.65968900
13MP0002735_abnormal_chemical_nociception2.65186403
14MP0002736_abnormal_nociception_after2.61652839
15MP0002822_catalepsy2.57611901
16MP0001188_hyperpigmentation2.56409224
17MP0001440_abnormal_grooming_behavior2.44273953
18MP0002734_abnormal_mechanical_nocicepti2.36046749
19MP0001486_abnormal_startle_reflex2.29728991
20MP0001501_abnormal_sleep_pattern2.20888173
21MP0002067_abnormal_sensory_capabilities2.16046347
22MP0008569_lethality_at_weaning2.02786441
23MP0002733_abnormal_thermal_nociception1.99981971
24MP0003690_abnormal_glial_cell1.99667331
25MP0001970_abnormal_pain_threshold1.93047260
26MP0005423_abnormal_somatic_nervous1.87790555
27MP0009780_abnormal_chondrocyte_physiolo1.83846355
28MP0002557_abnormal_social/conspecific_i1.78412990
29MP0002184_abnormal_innervation1.76201589
30MP0003303_peritoneal_inflammation1.76172752
31MP0004924_abnormal_behavior1.69935524
32MP0005386_behavior/neurological_phenoty1.69935524
33MP0003879_abnormal_hair_cell1.69933922
34MP0000920_abnormal_myelination1.66682716
35MP0000778_abnormal_nervous_system1.64370748
36MP0001529_abnormal_vocalization1.63607670
37MP0005646_abnormal_pituitary_gland1.62312117
38MP0009379_abnormal_foot_pigmentation1.52059112
39MP0004811_abnormal_neuron_physiology1.51912234
40MP0003787_abnormal_imprinting1.49145481
41MP0005645_abnormal_hypothalamus_physiol1.47561105
42MP0005248_abnormal_Harderian_gland1.46526108
43MP0006276_abnormal_autonomic_nervous1.41267333
44MP0003122_maternal_imprinting1.40760444
45MP0003634_abnormal_glial_cell1.39278623
46MP0004142_abnormal_muscle_tone1.39212660
47MP0000955_abnormal_spinal_cord1.37752787
48MP0002066_abnormal_motor_capabilities/c1.36182170
49MP0003329_amyloid_beta_deposits1.31360843
50MP0001502_abnormal_circadian_rhythm1.29245283
51MP0003633_abnormal_nervous_system1.28468776
52MP0002909_abnormal_adrenal_gland1.26223211
53MP0001984_abnormal_olfaction1.23907110
54MP0004130_abnormal_muscle_cell1.23755160
55MP0002882_abnormal_neuron_morphology1.19421258
56MP0005187_abnormal_penis_morphology1.11886526
57MP0002876_abnormal_thyroid_physiology1.10439990
58MP0008995_early_reproductive_senescence1.09139644
59MP0004145_abnormal_muscle_electrophysio1.07366446
60MP0001905_abnormal_dopamine_level1.03133005
61MP0004885_abnormal_endolymph1.03129853
62MP0003631_nervous_system_phenotype1.02132192
63MP0008877_abnormal_DNA_methylation1.01122789
64MP0002152_abnormal_brain_morphology1.00373105
65MP0004147_increased_porphyrin_level0.97748146
66MP0004742_abnormal_vestibular_system0.96866921
67MP0001986_abnormal_taste_sensitivity0.96388972
68MP0002069_abnormal_eating/drinking_beha0.94710783
69MP0003137_abnormal_impulse_conducting0.92165035
70MP0008874_decreased_physiological_sensi0.91334413
71MP0006292_abnormal_olfactory_placode0.91201731
72MP0008872_abnormal_physiological_respon0.89980967
73MP0004858_abnormal_nervous_system0.89374029
74MP0002837_dystrophic_cardiac_calcinosis0.84719935
75MP0005535_abnormal_body_temperature0.84528761
76MP0000026_abnormal_inner_ear0.84415332
77MP0003123_paternal_imprinting0.84177582
78MP0003283_abnormal_digestive_organ0.82790540
79MP0002638_abnormal_pupillary_reflex0.82131452
80MP0001963_abnormal_hearing_physiology0.79749931
81MP0001664_abnormal_digestion0.79412584
82MP0005394_taste/olfaction_phenotype0.79298818
83MP0005499_abnormal_olfactory_system0.79298818
84MP0000015_abnormal_ear_pigmentation0.77217816
85MP0005253_abnormal_eye_physiology0.77175587
86MP0004484_altered_response_of0.74536595
87MP0000751_myopathy0.74494753
88MP0010386_abnormal_urinary_bladder0.74039192
89MP0002653_abnormal_ependyma_morphology0.72459631
90MP0002229_neurodegeneration0.69603432
91MP0001177_atelectasis0.69241750
92MP0004085_abnormal_heartbeat0.68206798
93MP0005623_abnormal_meninges_morphology0.67776010
94MP0005409_darkened_coat_color0.67656733
95MP0003136_yellow_coat_color0.65936666
96MP0003861_abnormal_nervous_system0.65931169
97MP0003121_genomic_imprinting0.65646872
98MP0000604_amyloidosis0.64356671
99MP0000631_abnormal_neuroendocrine_gland0.63442524
100MP0005551_abnormal_eye_electrophysiolog0.62485932
101MP0002752_abnormal_somatic_nervous0.62457592
102MP0003868_abnormal_feces_composition0.62086172
103MP0002090_abnormal_vision0.60529078
104MP0003632_abnormal_nervous_system0.60166446
105MP0003646_muscle_fatigue0.57640951
106MP0004215_abnormal_myocardial_fiber0.56206873
107MP0000013_abnormal_adipose_tissue0.55686197
108MP0003119_abnormal_digestive_system0.55312294
109MP0001943_abnormal_respiration0.54656739
110MP0004134_abnormal_chest_morphology0.54373598
111MP0005167_abnormal_blood-brain_barrier0.53691904
112MP0004043_abnormal_pH_regulation0.53604184
113MP0010768_mortality/aging0.53074848
114MP0005595_abnormal_vascular_smooth0.52956420
115MP0003938_abnormal_ear_development0.52674602
116MP0010770_preweaning_lethality0.51760428
117MP0002082_postnatal_lethality0.51760428
118MP0003385_abnormal_body_wall0.51756379
119MP0001485_abnormal_pinna_reflex0.51723405
120MP0000579_abnormal_nail_morphology0.50984735
121MP0010769_abnormal_survival0.49967553
122MP0006072_abnormal_retinal_apoptosis0.49330595
123MP0003956_abnormal_body_size0.48441029
124MP0000747_muscle_weakness0.47640757

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.48012343
2Focal seizures (HP:0007359)5.38650256
3Myokymia (HP:0002411)5.21253716
4Epileptic encephalopathy (HP:0200134)4.98641119
5Atonic seizures (HP:0010819)4.88741561
6Febrile seizures (HP:0002373)4.47353912
7Visual hallucinations (HP:0002367)4.45993505
8Retinal atrophy (HP:0001105)4.45600300
9Retinal dysplasia (HP:0007973)4.32736093
10Hyperventilation (HP:0002883)4.14092128
11Absent speech (HP:0001344)4.13464874
12Scanning speech (HP:0002168)4.12928206
13Type II lissencephaly (HP:0007260)4.09305248
14Dialeptic seizures (HP:0011146)3.91107356
15Inability to walk (HP:0002540)3.85071959
16Progressive cerebellar ataxia (HP:0002073)3.84357647
17Absence seizures (HP:0002121)3.82875306
18Cerebellar dysplasia (HP:0007033)3.67957621
19Buphthalmos (HP:0000557)3.56058909
20Broad-based gait (HP:0002136)3.49396678
21Gaze-evoked nystagmus (HP:0000640)3.38858146
22Abnormal eating behavior (HP:0100738)3.30854403
23Neurofibrillary tangles (HP:0002185)3.29298928
24Anterior segment dysgenesis (HP:0007700)3.26052725
25Generalized tonic-clonic seizures (HP:0002069)3.22341579
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.22039035
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.22039035
28Abnormality of the corticospinal tract (HP:0002492)3.21356861
29Ankle clonus (HP:0011448)3.21215111
30Dysmetric saccades (HP:0000641)3.21177455
31Hepatoblastoma (HP:0002884)3.17806054
32Limb dystonia (HP:0002451)3.14216696
33Impaired vibration sensation in the lower limbs (HP:0002166)3.12392680
34Neoplasm of the adrenal cortex (HP:0100641)3.06163465
35Tented upper lip vermilion (HP:0010804)2.92032880
36Split foot (HP:0001839)2.91567784
37Action tremor (HP:0002345)2.88742337
38Oligodactyly (hands) (HP:0001180)2.87118623
39Dysdiadochokinesis (HP:0002075)2.81319704
40Hemiplegia (HP:0002301)2.77693734
41Poor eye contact (HP:0000817)2.77615123
42Truncal ataxia (HP:0002078)2.71022253
43Spinal rigidity (HP:0003306)2.65809986
44Cerebral hypomyelination (HP:0006808)2.64929376
45Amblyopia (HP:0000646)2.60478387
46Impaired smooth pursuit (HP:0007772)2.59241255
47Occipital encephalocele (HP:0002085)2.57688591
48Urinary bladder sphincter dysfunction (HP:0002839)2.55443682
49Dysmetria (HP:0001310)2.52772816
50Depression (HP:0000716)2.51487630
51Anxiety (HP:0000739)2.50745563
52Prolonged QT interval (HP:0001657)2.48756516
53Epileptiform EEG discharges (HP:0011182)2.48523125
54Mutism (HP:0002300)2.46670379
55Bradykinesia (HP:0002067)2.44872029
56Impaired social interactions (HP:0000735)2.44729531
57Abnormal social behavior (HP:0012433)2.44729531
58Slender build (HP:0001533)2.43834652
59Cerebral inclusion bodies (HP:0100314)2.40667545
60Difficulty climbing stairs (HP:0003551)2.38869578
61Peripheral hypomyelination (HP:0007182)2.33834587
62Drooling (HP:0002307)2.33410909
63Excessive salivation (HP:0003781)2.33410909
64Spastic gait (HP:0002064)2.30687446
65Torticollis (HP:0000473)2.30421239
66Bundle branch block (HP:0011710)2.28344602
67Ragged-red muscle fibers (HP:0003200)2.27665645
68Postural instability (HP:0002172)2.27480352
69Syncope (HP:0001279)2.27453783
70Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25607549
71Hypoplasia of the brainstem (HP:0002365)2.25607549
72EEG with generalized epileptiform discharges (HP:0011198)2.24610218
73Genetic anticipation (HP:0003743)2.24335095
74Impaired vibratory sensation (HP:0002495)2.23682316
75Annular pancreas (HP:0001734)2.19636898
76Stomach cancer (HP:0012126)2.19555142
77Congenital glaucoma (HP:0001087)2.17307895
78Abnormality of the lower motor neuron (HP:0002366)2.16298560
79Tetraplegia (HP:0002445)2.14277316
80Hemiparesis (HP:0001269)2.13823729
81Hypoventilation (HP:0002791)2.13389149
82Intellectual disability, profound (HP:0002187)2.13147001
83Severe muscular hypotonia (HP:0006829)2.11102916
84Fetal akinesia sequence (HP:0001989)2.10309330
85Abnormal hair whorl (HP:0010721)2.09917193
86Hypsarrhythmia (HP:0002521)2.09881342
87Status epilepticus (HP:0002133)2.09378260
88Oligomenorrhea (HP:0000876)2.08968788
89Focal dystonia (HP:0004373)2.08342968
90Papillary thyroid carcinoma (HP:0002895)2.07575546
91Abnormality of ocular smooth pursuit (HP:0000617)2.07288549
92Lissencephaly (HP:0001339)2.06508976
93Choreoathetosis (HP:0001266)2.05494753
94Polyphagia (HP:0002591)2.05423890
95Bell-shaped thorax (HP:0001591)2.05186405
96Abnormal EKG (HP:0003115)2.04922893
97Morphological abnormality of the pyramidal tract (HP:0002062)2.02258248
98Progressive inability to walk (HP:0002505)2.01973162
99Abnormality of binocular vision (HP:0011514)2.01765338
100Diplopia (HP:0000651)2.01765338
101Thyroid-stimulating hormone excess (HP:0002925)1.99339968
102Ventricular fibrillation (HP:0001663)1.98925016
103Poor suck (HP:0002033)1.98793281
104Stereotypic behavior (HP:0000733)1.97033780
105Gait imbalance (HP:0002141)1.96307648
106Sleep apnea (HP:0010535)1.96186055
107Urinary urgency (HP:0000012)1.94856771
108Spastic tetraplegia (HP:0002510)1.93946004
109Spastic tetraparesis (HP:0001285)1.93363465
110Type 1 muscle fiber predominance (HP:0003803)1.93129559
111Intellectual disability, moderate (HP:0002342)1.92788889
112Postural tremor (HP:0002174)1.92580441
113Optic nerve hypoplasia (HP:0000609)1.92094078
114Supranuclear gaze palsy (HP:0000605)1.91587624
115Neuronal loss in central nervous system (HP:0002529)1.89794386
116Pheochromocytoma (HP:0002666)1.89776290
117Akinesia (HP:0002304)1.89378044
118Nemaline bodies (HP:0003798)1.89336036
119Lower limb muscle weakness (HP:0007340)1.89228074
120Astrocytoma (HP:0009592)1.88341178
121Abnormality of the astrocytes (HP:0100707)1.88341178
122Clonus (HP:0002169)1.87881958
123Vitreoretinal degeneration (HP:0000655)1.86981393
124Intention tremor (HP:0002080)1.86968788
125Protruding tongue (HP:0010808)1.86617683
126Rigidity (HP:0002063)1.85823471
127Increased circulating renin level (HP:0000848)1.85735791
128Abnormality of saccadic eye movements (HP:0000570)1.84459673
129Limb-girdle muscle weakness (HP:0003325)1.84246903
130Oligodactyly (HP:0012165)1.83222378
131Open mouth (HP:0000194)1.82274836
132Non-midline cleft lip (HP:0100335)1.81408891
133Obstructive sleep apnea (HP:0002870)1.81281687
134Delusions (HP:0000746)1.79779029
135Congenital malformation of the right heart (HP:0011723)1.78562327
136Double outlet right ventricle (HP:0001719)1.78562327
137Tracheomalacia (HP:0002779)1.78475839
138Papilledema (HP:0001085)1.78184021
139Atrial fibrillation (HP:0005110)1.75180847
140Esotropia (HP:0000565)1.73279807
141Sudden death (HP:0001699)1.73022913
142Leukodystrophy (HP:0002415)1.71761830
143Megalencephaly (HP:0001355)1.71206763
144Rapidly progressive (HP:0003678)1.70394722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.41821186
2EPHA44.40535884
3NTRK33.86276910
4PNCK2.94375314
5MAP3K42.83212323
6MAP2K72.67402805
7MAP3K122.64227039
8DAPK22.56535777
9MINK12.53195217
10MAP3K92.48286991
11MARK12.44666502
12FES2.32129624
13CAMKK22.20829704
14CDK192.08583855
15PLK21.92098807
16RIPK41.89936209
17DAPK11.87726626
18KSR11.85360944
19MAP2K41.74485451
20NTRK21.68603811
21PAK61.68013300
22CAMKK11.65750834
23ARAF1.60765320
24PRPF4B1.57419598
25CCNB11.46013341
26PRKCG1.41278374
27KSR21.41219861
28CSNK1G21.39335879
29CSNK1A1L1.33800667
30CAMK1G1.31792236
31GRK51.30811100
32PKN11.27769053
33CDK51.25143329
34CSNK1G31.24808764
35AKT31.20579864
36TNIK1.16300208
37FER1.13259275
38OXSR11.13223929
39CAMK11.10184372
40MAPK131.10058867
41IRAK21.07898190
42SIK31.04476255
43SGK21.03478170
44SGK2231.02732740
45SGK4941.02732740
46BMPR20.98415352
47CAMK2A0.97716155
48SIK20.94647065
49CAMK2G0.92144195
50CAMK2B0.88113247
51CSNK1G10.82879696
52DMPK0.81444198
53STK380.78396944
54PTK2B0.78374773
55RAF10.75256528
56UHMK10.74443421
57CDK180.73732844
58ROCK10.73534826
59NTRK10.72891182
60TYRO30.72746384
61BRAF0.72384378
62NME10.70429588
63SGK30.68822894
64ALK0.68708910
65PINK10.67720022
66CDK150.67339983
67MAPK100.67191577
68PRKCE0.65948642
69MAP4K20.65745809
70FGFR20.65094939
71CDK140.64775790
72STK110.64351107
73SGK10.63523173
74WNK10.62930240
75YES10.61435281
76CDK11A0.59246829
77MARK20.58733781
78CAMK40.58205501
79DYRK1A0.57794073
80DYRK20.57464711
81DAPK30.52914903
82CAMK2D0.50254096
83WNK30.50175141
84FGR0.48646023
85TNK20.48393631
86MAP3K130.47574109
87RIPK10.46906297
88GRK70.45925935
89PRKCA0.44681213
90BCR0.44170010
91PRKD30.44085657
92NEK60.43811859
93PRKCZ0.43437265
94PRKD10.43322489
95PAK30.42762359
96MAP3K10.41894850
97PRKCH0.40371404
98LIMK10.39177048
99CSNK1A10.38641719
100MAP3K70.37844363
101STK38L0.37628699
102MOS0.37448240
103PHKG10.37197167
104PHKG20.37197167
105PRKACA0.37065530
106ROCK20.36809324
107MAPK120.36629376
108PRKG10.36460787
109PDK40.35997450
110PDK30.35997450
111PRKCB0.35894259
112STK390.35446201
113PDK10.35402108
114ADRBK10.35056194
115FYN0.34181983
116MAPK70.33879671
117LATS20.33512397
118CSNK1D0.33366110
119RPS6KA30.33029425
120TSSK60.32911737
121PDPK10.32648751
122ERBB20.31726012
123CSNK1E0.31416797
124INSRR0.30120365
125WNK40.29888129

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52815963
2Synaptic vesicle cycle_Homo sapiens_hsa047213.75478226
3Circadian entrainment_Homo sapiens_hsa047132.95778314
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92603382
5Glutamatergic synapse_Homo sapiens_hsa047242.78656982
6Amphetamine addiction_Homo sapiens_hsa050312.76533856
7Long-term potentiation_Homo sapiens_hsa047202.72738141
8GABAergic synapse_Homo sapiens_hsa047272.65010246
9Morphine addiction_Homo sapiens_hsa050322.60376072
10Olfactory transduction_Homo sapiens_hsa047402.49537529
11Collecting duct acid secretion_Homo sapiens_hsa049662.31894584
12Salivary secretion_Homo sapiens_hsa049702.31496953
13Long-term depression_Homo sapiens_hsa047302.20366765
14Dopaminergic synapse_Homo sapiens_hsa047282.13538938
15Taste transduction_Homo sapiens_hsa047421.96483093
16Renin secretion_Homo sapiens_hsa049241.92875282
17Insulin secretion_Homo sapiens_hsa049111.80336841
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76745238
19Cocaine addiction_Homo sapiens_hsa050301.75630816
20Cholinergic synapse_Homo sapiens_hsa047251.68789903
21Gastric acid secretion_Homo sapiens_hsa049711.68490319
22Oxytocin signaling pathway_Homo sapiens_hsa049211.67642942
23Serotonergic synapse_Homo sapiens_hsa047261.63456268
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59736665
25Calcium signaling pathway_Homo sapiens_hsa040201.59261645
26Gap junction_Homo sapiens_hsa045401.43006285
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38415562
28Sulfur metabolism_Homo sapiens_hsa009201.35556535
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34241949
30Vibrio cholerae infection_Homo sapiens_hsa051101.33340096
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33183666
32cAMP signaling pathway_Homo sapiens_hsa040241.31530574
33GnRH signaling pathway_Homo sapiens_hsa049121.20929928
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17251390
35Oxidative phosphorylation_Homo sapiens_hsa001901.12881763
36Cardiac muscle contraction_Homo sapiens_hsa042601.12830509
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10061826
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05421637
39Estrogen signaling pathway_Homo sapiens_hsa049151.00668568
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99461159
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99176047
42Axon guidance_Homo sapiens_hsa043600.97801872
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97174801
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94644746
45Alzheimers disease_Homo sapiens_hsa050100.94144522
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93655160
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.93483084
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91439690
49Ether lipid metabolism_Homo sapiens_hsa005650.91086932
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86880932
51Melanogenesis_Homo sapiens_hsa049160.86121245
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83041872
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82164110
54Phototransduction_Homo sapiens_hsa047440.80963433
55Glioma_Homo sapiens_hsa052140.80924386
56ErbB signaling pathway_Homo sapiens_hsa040120.80699778
57Parkinsons disease_Homo sapiens_hsa050120.72888872
58Type II diabetes mellitus_Homo sapiens_hsa049300.70766409
59Thyroid hormone synthesis_Homo sapiens_hsa049180.70005785
60MAPK signaling pathway_Homo sapiens_hsa040100.69187064
61Oocyte meiosis_Homo sapiens_hsa041140.68435247
62Pancreatic secretion_Homo sapiens_hsa049720.67833893
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61541334
64Dilated cardiomyopathy_Homo sapiens_hsa054140.59517029
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59414961
66Huntingtons disease_Homo sapiens_hsa050160.57973789
67beta-Alanine metabolism_Homo sapiens_hsa004100.57743397
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.55324150
69Circadian rhythm_Homo sapiens_hsa047100.54838865
70Histidine metabolism_Homo sapiens_hsa003400.54164416
71Choline metabolism in cancer_Homo sapiens_hsa052310.52443792
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51433732
73Endometrial cancer_Homo sapiens_hsa052130.49146908
74Wnt signaling pathway_Homo sapiens_hsa043100.49009213
75Rheumatoid arthritis_Homo sapiens_hsa053230.48881127
76Alcoholism_Homo sapiens_hsa050340.48179585
77Mineral absorption_Homo sapiens_hsa049780.47706325
78Ras signaling pathway_Homo sapiens_hsa040140.47257741
79Rap1 signaling pathway_Homo sapiens_hsa040150.46856510
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46277773
81Tight junction_Homo sapiens_hsa045300.45678721
82Arginine and proline metabolism_Homo sapiens_hsa003300.44472765
83Hippo signaling pathway_Homo sapiens_hsa043900.43796121
84Glucagon signaling pathway_Homo sapiens_hsa049220.42814465
85Dorso-ventral axis formation_Homo sapiens_hsa043200.42621209
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42523210
87Nitrogen metabolism_Homo sapiens_hsa009100.42056774
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.39082847
89Inositol phosphate metabolism_Homo sapiens_hsa005620.37816307
90Sphingolipid metabolism_Homo sapiens_hsa006000.36168766
91Type I diabetes mellitus_Homo sapiens_hsa049400.35970809
92Butanoate metabolism_Homo sapiens_hsa006500.35588414
93VEGF signaling pathway_Homo sapiens_hsa043700.35002935
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34946561
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34372562
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33474934
97Colorectal cancer_Homo sapiens_hsa052100.32124184
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31259209
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31242456
100Hedgehog signaling pathway_Homo sapiens_hsa043400.31239046
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30953321
102Melanoma_Homo sapiens_hsa052180.30589198
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29535136
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28784214
105Phagosome_Homo sapiens_hsa041450.28734740
106African trypanosomiasis_Homo sapiens_hsa051430.28707326
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.28510050
108Bile secretion_Homo sapiens_hsa049760.27029735
109Arginine biosynthesis_Homo sapiens_hsa002200.25114289
110Ovarian steroidogenesis_Homo sapiens_hsa049130.22745094
111Endocytosis_Homo sapiens_hsa041440.22354323
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20626538
113Prion diseases_Homo sapiens_hsa050200.19503941
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18920497
115Non-small cell lung cancer_Homo sapiens_hsa052230.17982551
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17103388

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