ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.94419835
2	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.63034778
3	neuronal action potential propagation (GO:0019227)	5.57617070
4	postsynaptic membrane organization (GO:0001941)	5.38461339
5	presynaptic membrane assembly (GO:0097105)	4.93931220
6	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.88418127
7	L-amino acid import (GO:0043092)	4.83965514
8	positive regulation of synapse maturation (GO:0090129)	4.79570068
9	regulation of synaptic vesicle exocytosis (GO:2000300)	4.75942514
10	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.73560029
11	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.71027826
12	synaptic vesicle exocytosis (GO:0016079)	4.61895328
13	synaptic transmission, dopaminergic (GO:0001963)	4.60922365
14	cellular potassium ion homeostasis (GO:0030007)	4.59988512
15	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.51225300
16	neuromuscular process controlling balance (GO:0050885)	4.50739142
17	glutamate receptor signaling pathway (GO:0007215)	4.45252496
18	adenosine receptor signaling pathway (GO:0001973)	4.44868646
19	positive regulation of synaptic transmission, GABAergic (GO:0032230)	4.41300147
20	regulation of synaptic vesicle transport (GO:1902803)	4.37679751
21	neuronal action potential (GO:0019228)	4.36614563
22	glutamate secretion (GO:0014047)	4.35248138
23	axon ensheathment in central nervous system (GO:0032291)	4.30165270
24	central nervous system myelination (GO:0022010)	4.30165270
25	cAMP catabolic process (GO:0006198)	4.27549285
26	membrane depolarization during action potential (GO:0086010)	4.26294492
27	startle response (GO:0001964)	4.24594646
28	behavioral fear response (GO:0001662)	4.20007154
29	behavioral defense response (GO:0002209)	4.20007154
30	neurotransmitter secretion (GO:0007269)	4.20007127
31	presynaptic membrane organization (GO:0097090)	4.19834920
32	endothelium development (GO:0003158)	4.14625740
33	locomotory exploration behavior (GO:0035641)	4.13970691
34	negative regulation of hormone biosynthetic process (GO:0032353)	4.04538148
35	cyclic nucleotide catabolic process (GO:0009214)	4.02527632
36	sodium ion export (GO:0071436)	3.90674571
37	cerebellar granule cell differentiation (GO:0021707)	3.85951153
38	exploration behavior (GO:0035640)	3.85667242
39	neuromuscular process (GO:0050905)	3.85407037
40	regulation of synapse structural plasticity (GO:0051823)	3.84579920
41	amino acid import (GO:0043090)	3.84439570
42	positive regulation of membrane potential (GO:0045838)	3.83440098
43	respiratory chain complex IV assembly (GO:0008535)	3.82259393
44	positive regulation of dendritic spine development (GO:0060999)	3.77027090
45	regulation of synapse maturation (GO:0090128)	3.76176298
46	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.73800998
47	negative regulation of dendrite morphogenesis (GO:0050774)	3.70110274
48	positive regulation of neurotransmitter transport (GO:0051590)	3.69584503
49	auditory behavior (GO:0031223)	3.69296300
50	neuronal ion channel clustering (GO:0045161)	3.69266019
51	neurotransmitter transport (GO:0006836)	3.65043226
52	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.64113979
53	fear response (GO:0042596)	3.63664815
54	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.62952642
55	positive regulation of neurotransmitter secretion (GO:0001956)	3.61969247
56	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.61916112
57	response to amphetamine (GO:0001975)	3.59958436
58	regulation of neurotransmitter secretion (GO:0046928)	3.58920962
59	regulation of neurotransmitter transport (GO:0051588)	3.56485739
60	neurotransmitter uptake (GO:0001504)	3.53908747
61	positive regulation of amino acid transport (GO:0051957)	3.53889479
62	short-term memory (GO:0007614)	3.46974329
63	DNA deamination (GO:0045006)	3.45611769
64	peptidyl-threonine dephosphorylation (GO:0035970)	3.42841187
65	vocalization behavior (GO:0071625)	3.42255044
66	neurotransmitter-gated ion channel clustering (GO:0072578)	3.41841491
67	protein localization to synapse (GO:0035418)	3.38060899
68	cellular response to ATP (GO:0071318)	3.37503305
69	facial nerve structural organization (GO:0021612)	3.37452141
70	regulation of synaptic transmission, GABAergic (GO:0032228)	3.36508443
71	negative regulation of hormone metabolic process (GO:0032351)	3.35426094
72	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.33943289
73	negative regulation of myotube differentiation (GO:0010832)	3.30559068
74	regulation of synaptic plasticity (GO:0048167)	3.30106603
75	prepulse inhibition (GO:0060134)	3.29500113
76	layer formation in cerebral cortex (GO:0021819)	3.29035891
77	regulation of neurotransmitter levels (GO:0001505)	3.26817556
78	cell communication by electrical coupling (GO:0010644)	3.26715623
79	substrate-independent telencephalic tangential migration (GO:0021826)	3.26699751
80	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.26699751
81	cell communication involved in cardiac conduction (GO:0086065)	3.26198791
82	membrane depolarization (GO:0051899)	3.25666032
83	behavioral response to cocaine (GO:0048148)	3.25650539
84	cytochrome complex assembly (GO:0017004)	3.24375347
85	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.23349879
86	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.22655662
87	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.21572569
88	action potential (GO:0001508)	3.21066986
89	detection of calcium ion (GO:0005513)	3.20953426
90	long-chain fatty acid biosynthetic process (GO:0042759)	3.20504057
91	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.18897449
92	negative regulation of neurotransmitter secretion (GO:0046929)	3.18741835
93	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.18283974
94	potassium ion import (GO:0010107)	3.16659599
95	synaptic vesicle maturation (GO:0016188)	3.16452641
96	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.13905154
97	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.13660044
98	serotonin metabolic process (GO:0042428)	3.12491646
99	mechanosensory behavior (GO:0007638)	3.11713660
100	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.11011972
101	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.11011972
102	glycosphingolipid biosynthetic process (GO:0006688)	3.09806243
103	astrocyte development (GO:0014002)	3.09657154
104	long-term memory (GO:0007616)	3.09577216
105	long-term synaptic potentiation (GO:0060291)	3.09476550
106	learning (GO:0007612)	3.08687732
107	potassium ion homeostasis (GO:0055075)	3.07349671
108	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.07209078
109	negative regulation of neurotransmitter transport (GO:0051589)	3.06618918
110	regulation of Rap GTPase activity (GO:0032317)	3.05661577
111	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.04815578
112	regulation of protein kinase A signaling (GO:0010738)	3.04057546
113	adult walking behavior (GO:0007628)	3.03951755
114	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.02096402
115	mannosylation (GO:0097502)	3.02023824
116	positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)	3.01485505
117	dopamine receptor signaling pathway (GO:0007212)	3.00466994
118	striatum development (GO:0021756)	3.00247407
119	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.99236173
120	regulation of norepinephrine secretion (GO:0014061)	2.99076089
121	regulation of pigment cell differentiation (GO:0050932)	2.96952779
122	peristalsis (GO:0030432)	2.96655591
123	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.94569476
124	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.92840211
125	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.92393957
126	cotranslational protein targeting to membrane (GO:0006613)	2.91431533
127	negative regulation of catecholamine secretion (GO:0033604)	2.91080939
128	protein targeting to ER (GO:0045047)	2.89990494
129	myeloid leukocyte mediated immunity (GO:0002444)	2.88351619
130	cerebellar Purkinje cell layer development (GO:0021680)	2.88209623
131	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.87592210
132	visual learning (GO:0008542)	2.86917978
133	neuron-neuron synaptic transmission (GO:0007270)	2.85938879
134	response to auditory stimulus (GO:0010996)	2.81577241
135	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	2.81256917
136	viral transcription (GO:0019083)	2.81146406
137	negative regulation of norepinephrine secretion (GO:0010700)	2.80867577
138	GDP-mannose metabolic process (GO:0019673)	2.80349304
139	cAMP metabolic process (GO:0046058)	2.78526597
140	cranial nerve morphogenesis (GO:0021602)	2.77483232
141	regulation of glutamate receptor signaling pathway (GO:1900449)	2.76787105
142	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.76133008
143	protein localization to endoplasmic reticulum (GO:0070972)	2.75659560
144	signal peptide processing (GO:0006465)	2.74302637
145	regulation of neuronal synaptic plasticity (GO:0048168)	2.73819194
146	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.73079278
147	regulation of dendritic spine morphogenesis (GO:0061001)	2.72462292
148	regulation of glutamate secretion (GO:0014048)	2.71870553
149	neuron cell-cell adhesion (GO:0007158)	2.69911856
150	regulation of dendritic spine development (GO:0060998)	2.69383823
151	protein heterotetramerization (GO:0051290)	2.68695187
152	dendritic spine morphogenesis (GO:0060997)	2.67012660
153	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.66932447
154	amino sugar catabolic process (GO:0046348)	2.66422864
155	translational termination (GO:0006415)	2.64846833
156	synaptic transmission, glutamatergic (GO:0035249)	2.64439606
157	regulation of postsynaptic membrane potential (GO:0060078)	2.64009055
158	regulation of respiratory system process (GO:0044065)	2.63660271
159	visual behavior (GO:0007632)	2.62409429
160	regulation of dopamine metabolic process (GO:0042053)	2.61979983
161	regulation of catecholamine metabolic process (GO:0042069)	2.61979983
162	regulation of respiratory gaseous exchange (GO:0043576)	2.55980887
163	cranial nerve structural organization (GO:0021604)	2.54876025
164	regulation of neurotransmitter uptake (GO:0051580)	2.54799332
165	developmental pigmentation (GO:0048066)	2.53680695
166	gamma-aminobutyric acid transport (GO:0015812)	2.53467256
167	transmission of nerve impulse (GO:0019226)	2.53269710
168	regulation of voltage-gated calcium channel activity (GO:1901385)	2.52581737

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.95244747
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.78303034
3	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.37611797
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.15179130
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.80240379
6	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.74659989
7	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.74406496
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.67823017
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.64181545
10	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.44247011
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.37728449
12	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.37728449
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.35238185
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30860737
15	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.29785315
16	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.25087240
17	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.21840318
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.19216853
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.17502962
20	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.14831727
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.14352456
22	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.10955316
23	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.99465570
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.96707551
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.89273731
26	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.89013407
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85592769
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83713672
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.79410830
30	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.71967904
31	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.70723914
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70610474
33	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69168384
34	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.67088375
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.66186014
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65386378
37	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.60178771
38	DROSHA_22980978_ChIP-Seq_HELA_Human	1.59046067
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58549096
40	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.58155081
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57737166
42	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.57381540
43	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56529925
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53419011
45	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52661929
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49953047
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48594979
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48093541
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46787925
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44612263
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.44039350
52	TCF4_23295773_ChIP-Seq_U87_Human	1.43203500
53	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.41945781
54	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.41886309
55	STAT3_23295773_ChIP-Seq_U87_Human	1.41318602
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39956916
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.32475549
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.32054503
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30027583
60	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.29313608
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28700650
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28700650
63	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.27299553
64	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.25984980
65	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.25414212
66	AR_19668381_ChIP-Seq_PC3_Human	1.24483480
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23484035
68	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22578685
69	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.22295417
70	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21070785
71	AR_25329375_ChIP-Seq_VCAP_Human	1.17657754
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.16929247
73	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.16793112
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15528061
75	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14942748
76	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.14244367
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13803303
78	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.13639647
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.12485766
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.12424005
81	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12390556
82	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11921166
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10863371
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10414737
85	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09911449
86	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09905464
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.09397208
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.08321091
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07940647
90	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.07700811
91	SOX9_26525672_Chip-Seq_HEART_Mouse	1.06465654
92	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.03893242
93	JUN_21703547_ChIP-Seq_K562_Human	1.03765161
94	P300_18555785_Chip-Seq_ESCs_Mouse	1.03701468
95	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02027509
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01750667
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00354007
98	TCF4_22108803_ChIP-Seq_LS180_Human	1.00281967
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99811464
100	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99615397
101	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99528060
102	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99401604
103	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99382976
104	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.99114372
105	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.98811541
106	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.98155528
107	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97286305
108	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96920690
109	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96759210
110	TP53_16413492_ChIP-PET_HCT116_Human	0.96686973
111	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96603885
112	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96094580
113	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.95050765
114	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.93909409
115	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93378638
116	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93215427
117	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93063981
118	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.92819094
119	SMAD4_21799915_ChIP-Seq_A2780_Human	0.92250214
120	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91518121
121	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91276733
122	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.90724144
123	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.90399637
124	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.89694407
125	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.89435695
126	P300_19829295_ChIP-Seq_ESCs_Human	0.89203120
127	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88854402
128	PU1_27457419_Chip-Seq_LIVER_Mouse	0.87332217
129	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.87209323
130	CTCF_27219007_Chip-Seq_Bcells_Human	0.86134605
131	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.84287103
132	VDR_24763502_ChIP-Seq_THP-1_Human	0.83443717
133	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.82765571
134	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.82613282
135	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.81867506
136	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.81643369
137	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.81512891
138	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81450899
139	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.81429672
140	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.81104467
141	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.80962168
142	SCL_19346495_ChIP-Seq_HPC-7_Human	0.79754945
143	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79380028
144	KDM2B_26808549_Chip-Seq_REH_Human	0.79202051

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.12323468
2	MP0002822_catalepsy	4.82634925
3	MP0001188_hyperpigmentation	4.60614711
4	MP0005409_darkened_coat_color	4.33760505
5	MP0003880_abnormal_central_pattern	3.90987306
6	MP0003724_increased_susceptibility_to	3.02986299
7	MP0003303_peritoneal_inflammation	2.87700837
8	MP0001986_abnormal_taste_sensitivity	2.73007980
9	MP0004859_abnormal_synaptic_plasticity	2.67059681
10	MP0005174_abnormal_tail_pigmentation	2.49338415
11	MP0003635_abnormal_synaptic_transmissio	2.42165836
12	MP0000015_abnormal_ear_pigmentation	2.38981352
13	MP0006292_abnormal_olfactory_placode	2.38665709
14	MP0009745_abnormal_behavioral_response	2.37499849
15	MP0003690_abnormal_glial_cell	2.35887687
16	MP0000569_abnormal_digit_pigmentation	2.35114834
17	MP0003136_yellow_coat_color	2.31059737
18	MP0001440_abnormal_grooming_behavior	2.00783445
19	MP0005423_abnormal_somatic_nervous	1.95051146
20	MP0004270_analgesia	1.92656735
21	MP0001486_abnormal_startle_reflex	1.87277892
22	MP0002272_abnormal_nervous_system	1.80217662
23	MP0001968_abnormal_touch/_nociception	1.78776151
24	MP0002909_abnormal_adrenal_gland	1.78645482
25	MP0001529_abnormal_vocalization	1.75413150
26	MP0001485_abnormal_pinna_reflex	1.72042260
27	MP0004885_abnormal_endolymph	1.69953915
28	MP0003879_abnormal_hair_cell	1.68995660
29	MP0002063_abnormal_learning/memory/cond	1.67932902
30	MP0002064_seizures	1.63991019
31	MP0002572_abnormal_emotion/affect_behav	1.63663946
32	MP0002876_abnormal_thyroid_physiology	1.59882850
33	MP0005646_abnormal_pituitary_gland	1.57203298
34	MP0002734_abnormal_mechanical_nocicepti	1.56875302
35	MP0000372_irregular_coat_pigmentation	1.56798013
36	MP0001970_abnormal_pain_threshold	1.56585159
37	MP0000778_abnormal_nervous_system	1.56305760
38	MP0002095_abnormal_skin_pigmentation	1.50997558
39	MP0003122_maternal_imprinting	1.49180266
40	MP0002557_abnormal_social/conspecific_i	1.41940981
41	MP0002638_abnormal_pupillary_reflex	1.41426459
42	MP0003631_nervous_system_phenotype	1.38151962
43	MP0009046_muscle_twitch	1.37430085
44	MP0006276_abnormal_autonomic_nervous	1.35269430
45	MP0004381_abnormal_hair_follicle	1.35108581
46	MP0000631_abnormal_neuroendocrine_gland	1.34135602
47	MP0003787_abnormal_imprinting	1.33307427
48	MP0004147_increased_porphyrin_level	1.31892116
49	MP0003646_muscle_fatigue	1.31294918
50	MP0008569_lethality_at_weaning	1.28844525
51	MP0000681_abnormal_thyroid_gland	1.27665121
52	MP0005379_endocrine/exocrine_gland_phen	1.26207705
53	MP0003329_amyloid_beta_deposits	1.25769236
54	MP0008260_abnormal_autophagy	1.24455877
55	MP0001905_abnormal_dopamine_level	1.24158389
56	MP0003634_abnormal_glial_cell	1.23721911
57	MP0004142_abnormal_muscle_tone	1.21630293
58	MP0002067_abnormal_sensory_capabilities	1.21242898
59	MP0005075_abnormal_melanosome_morpholog	1.17711955
60	MP0008877_abnormal_DNA_methylation	1.16884424
61	MP0002733_abnormal_thermal_nociception	1.15913069
62	MP0001502_abnormal_circadian_rhythm	1.15232413
63	MP0001501_abnormal_sleep_pattern	1.13856695
64	MP0001984_abnormal_olfaction	1.07882603
65	MP0002152_abnormal_brain_morphology	1.06002246
66	MP0002177_abnormal_outer_ear	1.05974137
67	MP0001963_abnormal_hearing_physiology	1.05555295
68	MP0000613_abnormal_salivary_gland	1.05357533
69	MP0009780_abnormal_chondrocyte_physiolo	1.04836090
70	MP0000678_abnormal_parathyroid_gland	1.03668253
71	MP0005645_abnormal_hypothalamus_physiol	1.02884098
72	MP0002751_abnormal_autonomic_nervous	1.02853237
73	MP0003632_abnormal_nervous_system	1.02683000
74	MP0002693_abnormal_pancreas_physiology	1.02158480
75	MP0005595_abnormal_vascular_smooth	1.00298728
76	MP0004510_myositis	0.99243756
77	MP0001944_abnormal_pancreas_morphology	0.96319551
78	MP0002090_abnormal_vision	0.95034251
79	MP0002148_abnormal_hypersensitivity_rea	0.92376120
80	MP0001299_abnormal_eye_distance/	0.90346231
81	MP0002160_abnormal_reproductive_system	0.88364171
82	MP0002736_abnormal_nociception_after	0.86193501
83	MP0002184_abnormal_innervation	0.85742921
84	MP0005386_behavior/neurological_phenoty	0.85652843
85	MP0004924_abnormal_behavior	0.85652843
86	MP0003866_abnormal_defecation	0.84683565
87	MP0002163_abnormal_gland_morphology	0.84409672
88	MP0002735_abnormal_chemical_nociception	0.83566663
89	MP0003137_abnormal_impulse_conducting	0.81161160
90	MP0008872_abnormal_physiological_respon	0.80774150
91	MP0002877_abnormal_melanocyte_morpholog	0.80437799
92	MP0001919_abnormal_reproductive_system	0.76846765
93	MP0003283_abnormal_digestive_organ	0.75915866
94	MP0000049_abnormal_middle_ear	0.75905100
95	MP0005671_abnormal_response_to	0.75574153
96	MP0000920_abnormal_myelination	0.75346074
97	MP0000955_abnormal_spinal_cord	0.74336060
98	MP0003890_abnormal_embryonic-extraembry	0.73792806
99	MP0003828_pulmonary_edema	0.73688847
100	MP0002066_abnormal_motor_capabilities/c	0.72614949
101	MP0003868_abnormal_feces_composition	0.72548060
102	MP0002882_abnormal_neuron_morphology	0.72128017
103	MP0003121_genomic_imprinting	0.72039281
104	MP0010386_abnormal_urinary_bladder	0.71286341
105	MP0004811_abnormal_neuron_physiology	0.70940038
106	MP0005084_abnormal_gallbladder_morpholo	0.69755400
107	MP0002102_abnormal_ear_morphology	0.69575467
108	MP0001177_atelectasis	0.68626703
109	MP0001664_abnormal_digestion	0.67547801
110	MP0009785_altered_susceptibility_to	0.67147035
111	MP0005000_abnormal_immune_tolerance	0.66653656
112	MP0005394_taste/olfaction_phenotype	0.66220360
113	MP0005499_abnormal_olfactory_system	0.66220360
114	MP0008874_decreased_physiological_sensi	0.66131373
115	MP0001346_abnormal_lacrimal_gland	0.64651674
116	MP0005551_abnormal_eye_electrophysiolog	0.64107941
117	MP0002075_abnormal_coat/hair_pigmentati	0.63918568
118	MP0002229_neurodegeneration	0.63864605
119	MP0003172_abnormal_lysosome_physiology	0.63450189
120	MP0002069_abnormal_eating/drinking_beha	0.63395594
121	MP0004043_abnormal_pH_regulation	0.63239090
122	MP0003123_paternal_imprinting	0.62932067
123	MP0002752_abnormal_somatic_nervous	0.62864478
124	MP0001186_pigmentation_phenotype	0.62711378
125	MP0002933_joint_inflammation	0.61952646
126	MP0010769_abnormal_survival	0.61365127
127	MP0004742_abnormal_vestibular_system	0.61302063
128	MP0010770_preweaning_lethality	0.60610037
129	MP0002082_postnatal_lethality	0.60610037
130	MP0003878_abnormal_ear_physiology	0.59876282
131	MP0005377_hearing/vestibular/ear_phenot	0.59876282
132	MP0005167_abnormal_blood-brain_barrier	0.58432159
133	MP0005171_absent_coat_pigmentation	0.58166159
134	MP0010768_mortality/aging	0.57657739
135	MP0003763_abnormal_thymus_physiology	0.57235137
136	MP0005535_abnormal_body_temperature	0.57196954
137	MP0003633_abnormal_nervous_system	0.56637384
138	MP0002653_abnormal_ependyma_morphology	0.56411717
139	MP0005248_abnormal_Harderian_gland	0.56258596
140	MP0005187_abnormal_penis_morphology	0.55219144
141	MP0009672_abnormal_birth_weight	0.53452605
142	MP0003861_abnormal_nervous_system	0.50250005
143	MP0001943_abnormal_respiration	0.49520732
144	MP0002254_reproductive_system_inflammat	0.49333804

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	6.53739592
2	Type I transferrin isoform profile (HP:0003642)	6.26479411
3	Focal motor seizures (HP:0011153)	4.69965624
4	Torticollis (HP:0000473)	4.66533700
5	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	4.62747053
6	Abnormal protein N-linked glycosylation (HP:0012347)	4.62747053
7	Abnormal protein glycosylation (HP:0012346)	4.62747053
8	Abnormal glycosylation (HP:0012345)	4.62747053
9	Epileptic encephalopathy (HP:0200134)	4.40293043
10	Generalized tonic-clonic seizures (HP:0002069)	4.37920449
11	Annular pancreas (HP:0001734)	4.09967234
12	Hypothermia (HP:0002045)	4.08055625
13	Dialeptic seizures (HP:0011146)	3.95972255
14	Myokymia (HP:0002411)	3.82790047
15	Craniofacial dystonia (HP:0012179)	3.76490996
16	Atonic seizures (HP:0010819)	3.75940526
17	Cortical visual impairment (HP:0100704)	3.70901903
18	Focal dystonia (HP:0004373)	3.69902300
19	Supranuclear gaze palsy (HP:0000605)	3.66277063
20	Truncal ataxia (HP:0002078)	3.63629252
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.62068704
22	Obstructive sleep apnea (HP:0002870)	3.56010691
23	Absence seizures (HP:0002121)	3.46904407
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.44548390
25	Mutism (HP:0002300)	3.40883058
26	Severe visual impairment (HP:0001141)	3.30153296
27	Abnormality of binocular vision (HP:0011514)	3.25187017
28	Diplopia (HP:0000651)	3.25187017
29	Pheochromocytoma (HP:0002666)	3.23204832
30	Neurofibrillary tangles (HP:0002185)	3.18551672
31	Epileptiform EEG discharges (HP:0011182)	3.15566309
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.12828124
33	Ocular albinism (HP:0001107)	3.08683140
34	Progressive cerebellar ataxia (HP:0002073)	3.08334719
35	Nonprogressive disorder (HP:0003680)	3.05994416
36	Abnormality of magnesium homeostasis (HP:0004921)	3.05993033
37	Gaze-evoked nystagmus (HP:0000640)	3.02570311
38	Increased hepatocellular lipid droplets (HP:0006565)	3.00505056
39	Hyperventilation (HP:0002883)	3.00049872
40	Thyroid-stimulating hormone excess (HP:0002925)	2.93769497
41	Renal Fanconi syndrome (HP:0001994)	2.91262007
42	Dysmetria (HP:0001310)	2.90586966
43	EEG with generalized epileptiform discharges (HP:0011198)	2.89759075
44	Poor eye contact (HP:0000817)	2.89397679
45	Hemiparesis (HP:0001269)	2.88654112
46	Postural instability (HP:0002172)	2.86397272
47	Intention tremor (HP:0002080)	2.81586474
48	Iris hypopigmentation (HP:0007730)	2.78667076
49	Hemiplegia (HP:0002301)	2.73565539
50	Exertional dyspnea (HP:0002875)	2.72771619
51	Ankle clonus (HP:0011448)	2.69986028
52	Spastic gait (HP:0002064)	2.69470220
53	Hypsarrhythmia (HP:0002521)	2.65602226
54	Dysdiadochokinesis (HP:0002075)	2.62809281
55	Spastic tetraparesis (HP:0001285)	2.61718173
56	Split foot (HP:0001839)	2.60251884
57	Neuroendocrine neoplasm (HP:0100634)	2.59146476
58	Flat occiput (HP:0005469)	2.57488637
59	Abnormal sex determination (HP:0012244)	2.56611797
60	Sex reversal (HP:0012245)	2.56611797
61	Chronic obstructive pulmonary disease (HP:0006510)	2.55248374
62	Obstructive lung disease (HP:0006536)	2.55248374
63	Hepatocellular necrosis (HP:0001404)	2.53558095
64	Abnormal rod and cone electroretinograms (HP:0008323)	2.53278126
65	Abnormal social behavior (HP:0012433)	2.50395209
66	Impaired social interactions (HP:0000735)	2.50395209
67	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.49126557
68	Scanning speech (HP:0002168)	2.48477654
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.47356296
70	Attenuation of retinal blood vessels (HP:0007843)	2.46762936
71	Hepatoblastoma (HP:0002884)	2.46343108
72	Increased circulating renin level (HP:0000848)	2.45303960
73	Stomatitis (HP:0010280)	2.44952490
74	Agitation (HP:0000713)	2.44291551
75	Late onset (HP:0003584)	2.44133131
76	True hermaphroditism (HP:0010459)	2.42490107
77	Cerebral inclusion bodies (HP:0100314)	2.40468916
78	Sleep apnea (HP:0010535)	2.39669218
79	Spinal canal stenosis (HP:0003416)	2.36146841
80	Heart block (HP:0012722)	2.35597612
81	Testicular atrophy (HP:0000029)	2.35205229
82	Anxiety (HP:0000739)	2.34866666
83	Focal seizures (HP:0007359)	2.34759493
84	Bradykinesia (HP:0002067)	2.33658913
85	Lipid accumulation in hepatocytes (HP:0006561)	2.33532137
86	Prolonged QT interval (HP:0001657)	2.31413670
87	Abnormal number of erythroid precursors (HP:0012131)	2.30743219
88	Peripheral hypomyelination (HP:0007182)	2.29281457
89	Abnormality of the corticospinal tract (HP:0002492)	2.28194117
90	Drooling (HP:0002307)	2.27832858
91	Inability to walk (HP:0002540)	2.27376627
92	Status epilepticus (HP:0002133)	2.26394366
93	Akinesia (HP:0002304)	2.24577698
94	Papilledema (HP:0001085)	2.19970563
95	Polyphagia (HP:0002591)	2.17723211
96	Impaired vibration sensation in the lower limbs (HP:0002166)	2.17692550
97	Abnormality of the axillary hair (HP:0100134)	2.17624769
98	Abnormality of secondary sexual hair (HP:0009888)	2.17624769
99	Lower limb hyperreflexia (HP:0002395)	2.17111999
100	Horizontal nystagmus (HP:0000666)	2.16900670
101	Inappropriate behavior (HP:0000719)	2.16001781
102	Concave nail (HP:0001598)	2.15557240
103	Abnormality of cells of the erythroid lineage (HP:0012130)	2.15366725
104	Abnormality of dental color (HP:0011073)	2.15317205
105	Increased intramyocellular lipid droplets (HP:0012240)	2.13762921
106	Urinary bladder sphincter dysfunction (HP:0002839)	2.12572786
107	Abnormal eating behavior (HP:0100738)	2.12082116
108	Stereotypic behavior (HP:0000733)	2.11414606
109	Bronchomalacia (HP:0002780)	2.11256209
110	Abnormality of cochlea (HP:0000375)	2.08596475
111	Bundle branch block (HP:0011710)	2.08394326
112	Excessive salivation (HP:0003781)	2.07721644
113	Amblyopia (HP:0000646)	2.06316748
114	Limb dystonia (HP:0002451)	2.06027261
115	Atrioventricular block (HP:0001678)	2.04962059
116	Hypomagnesemia (HP:0002917)	2.04314715
117	Spastic tetraplegia (HP:0002510)	2.04298473
118	Abnormal atrioventricular conduction (HP:0005150)	2.03172412
119	Thoracic kyphosis (HP:0002942)	2.00887286
120	Postural tremor (HP:0002174)	2.00869897
121	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.00026153
122	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.00026153
123	Depression (HP:0000716)	1.99016244
124	Papillary thyroid carcinoma (HP:0002895)	1.97767827
125	Visual hallucinations (HP:0002367)	1.97309529
126	Protruding tongue (HP:0010808)	1.96535636
127	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96088803
128	Lower limb muscle weakness (HP:0007340)	1.96077509
129	Febrile seizures (HP:0002373)	1.95644768
130	Impaired smooth pursuit (HP:0007772)	1.94646784
131	Hepatic necrosis (HP:0002605)	1.94599574
132	Hypoglycemic seizures (HP:0002173)	1.94097454
133	Dry hair (HP:0011359)	1.93714652
134	Abnormality of renal resorption (HP:0011038)	1.93649542
135	Astrocytoma (HP:0009592)	1.92829502
136	Abnormality of the astrocytes (HP:0100707)	1.92829502
137	Reticulocytopenia (HP:0001896)	1.91586037
138	Urinary urgency (HP:0000012)	1.90981659
139	Limb ataxia (HP:0002070)	1.90606820
140	Broad-based gait (HP:0002136)	1.90442216
141	Apathy (HP:0000741)	1.90282298
142	Progressive inability to walk (HP:0002505)	1.89989372
143	Aqueductal stenosis (HP:0002410)	1.89780907
144	Acute lymphatic leukemia (HP:0006721)	1.89607583
145	Congenital sensorineural hearing impairment (HP:0008527)	1.89225703
146	Hyperparathyroidism (HP:0000843)	1.89109484
147	Hyperphosphaturia (HP:0003109)	1.88658686
148	Rapidly progressive (HP:0003678)	1.87942855
149	Absent speech (HP:0001344)	1.87669851
150	Aplasia involving bones of the upper limbs (HP:0009823)	1.87637489
151	Aplasia of the phalanges of the hand (HP:0009802)	1.87637489
152	Aplasia involving bones of the extremities (HP:0009825)	1.87637489
153	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.86256237
154	Microvesicular hepatic steatosis (HP:0001414)	1.86026391
155	Neuronal loss in central nervous system (HP:0002529)	1.85631318
156	Incomplete penetrance (HP:0003829)	1.85582794
157	Intellectual disability, profound (HP:0002187)	1.85513321
158	Morphological abnormality of the inner ear (HP:0011390)	1.85390852
159	Pancreatic fibrosis (HP:0100732)	1.84411222
160	Muscular hypotonia of the trunk (HP:0008936)	1.84334085
161	Meningitis (HP:0001287)	1.84010673
162	Turricephaly (HP:0000262)	1.83869177
163	Abnormal pupillary function (HP:0007686)	1.81874520
164	Macrocytic anemia (HP:0001972)	1.81535077
165	Aplastic anemia (HP:0001915)	1.81047511
166	Mitral regurgitation (HP:0001653)	1.80158165
167	Progressive muscle weakness (HP:0003323)	1.80030751
168	Mitochondrial inheritance (HP:0001427)	1.79805725
169	Microcytic anemia (HP:0001935)	1.79708795
170	Progressive external ophthalmoplegia (HP:0000590)	1.79662766
171	Bradycardia (HP:0001662)	1.79547494
172	Unilateral renal agenesis (HP:0000122)	1.77628328
173	Elevated erythrocyte sedimentation rate (HP:0003565)	1.76925443
174	Type 2 muscle fiber atrophy (HP:0003554)	1.76434061
175	3-Methylglutaconic aciduria (HP:0003535)	1.75502414
176	Pancreatic cysts (HP:0001737)	1.75139610
177	Hyperphosphatemia (HP:0002905)	1.74846274
178	Decreased central vision (HP:0007663)	1.74821126
179	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73739587
180	Action tremor (HP:0002345)	1.68115795
181	Hypoplasia of the fovea (HP:0007750)	1.64254395
182	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.64254395
183	Muscle fiber atrophy (HP:0100295)	1.64104105
184	Abnormality of the columella (HP:0009929)	1.63881080
185	Capillary hemangiomas (HP:0005306)	1.61781764

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	6.13970742
2	FES	4.55859617
3	EIF2AK3	4.51026794
4	CAMKK2	3.51507175
5	EPHA4	3.44493255
6	MUSK	3.23179720
7	MAP3K9	3.22168663
8	MKNK2	3.08191621
9	RIPK1	2.42803326
10	CASK	2.31133013
11	STK16	2.29517877
12	CAMK1D	2.22462958
13	NLK	2.15848539
14	MAP2K7	2.13636869
15	CAMK1G	2.09529589
16	NTRK3	1.90814236
17	TLK1	1.87861137
18	PNCK	1.85984622
19	PRPF4B	1.84684743
20	IRAK3	1.82896591
21	NME2	1.80433009
22	RIPK4	1.79842303
23	IRAK4	1.75063409
24	CAMKK1	1.62621672
25	MKNK1	1.57385523
26	CDK19	1.47792902
27	CAMK1	1.46011330
28	PAK6	1.44258353
29	TEC	1.44018839
30	EIF2AK2	1.41805235
31	MAP3K12	1.33864959
32	PRKD2	1.33791367
33	ACVR1B	1.32302883
34	FER	1.32040279
35	MAP3K4	1.29098024
36	FGFR2	1.25898993
37	MAPK13	1.25470858
38	IRAK2	1.22227348
39	SGK1	1.15833693
40	SGK494	1.15635005
41	SGK223	1.15635005
42	SGK2	1.15503597
43	HIPK2	1.13723996
44	UHMK1	1.13623884
45	LATS2	1.12750659
46	OXSR1	1.09228006
47	PIM2	1.09157399
48	PHKG2	1.08315215
49	PHKG1	1.08315215
50	MINK1	1.07453887
51	PINK1	1.03549248
52	BMPR2	1.01538344
53	BLK	0.99781997
54	CLK1	0.93555667
55	TYRO3	0.93058896
56	IRAK1	0.91636203
57	ALK	0.90833864
58	MAP3K1	0.88144052
59	TSSK6	0.85112138
60	PRKD3	0.83045167
61	KSR2	0.79797854
62	PIK3CG	0.76545555
63	ADRBK2	0.76227202
64	WNK3	0.75584076
65	SIK2	0.74442213
66	EIF2AK1	0.69920134
67	STK39	0.69433726
68	RPS6KA3	0.68867242
69	CAMK2B	0.68327661
70	CSK	0.66183676
71	FRK	0.65947845
72	MAP2K4	0.65715496
73	DAPK2	0.64240224
74	VRK1	0.62913549
75	YES1	0.62134233
76	PLK2	0.61536083
77	SGK3	0.58745798
78	LYN	0.57066413
79	MAPK10	0.56839423
80	CDK5	0.56660258
81	DYRK2	0.56635630
82	CAMK2G	0.56135567
83	IKBKE	0.54815542
84	LMTK2	0.54663300
85	HCK	0.54266573
86	ARAF	0.52738449
87	MARK2	0.52459735
88	INSRR	0.52404685
89	MAPKAPK5	0.51931305
90	CAMK4	0.50924930
91	CDK15	0.50489706
92	NEK6	0.49803538
93	PRKCH	0.49284301
94	STK11	0.49209626
95	PRKG1	0.49120581
96	SRPK1	0.48713900
97	CAMK2A	0.48649053
98	CAMK2D	0.47981663
99	CDK18	0.46300678
100	NTRK1	0.46215836
101	TNK2	0.46046310
102	BTK	0.45356142
103	SYK	0.45053118
104	CSNK1E	0.44860331
105	ROCK2	0.44674834
106	DAPK1	0.44412785
107	MAPK4	0.41285546
108	GRK5	0.40829334
109	MARK1	0.40750599
110	PRKCB	0.40568552
111	ADRBK1	0.39642845
112	CDK14	0.39576595
113	CSNK1A1	0.39565909
114	CSNK1G3	0.39488146
115	TXK	0.39224699
116	KIT	0.37893719
117	CSNK1A1L	0.36559686
118	CDK8	0.36202940
119	MAPK15	0.36123867
120	MAP3K13	0.35743220
121	CSNK1D	0.35436175
122	NTRK2	0.33570555
123	WNK1	0.33432205
124	PRKG2	0.32678560
125	BRD4	0.32316726
126	PRKDC	0.32166105
127	LCK	0.30908448
128	GSK3B	0.30850376
129	BMPR1B	0.30695710
130	WEE1	0.30322404
131	CDK3	0.30194154
132	PRKACB	0.29564796
133	RET	0.29471280
134	MAP3K5	0.29455825
135	PRKCZ	0.29410175
136	TAOK1	0.29246288
137	BUB1	0.28459730
138	DYRK1A	0.28214167
139	PRKCG	0.28213051
140	TAOK3	0.27964977
141	IKBKB	0.26979778
142	PRKCA	0.26797025
143	PRKACA	0.26640455
144	FYN	0.26065411
145	CSNK1G1	0.25583895
146	MAP3K2	0.25565863
147	CSNK1G2	0.25532272
148	ABL2	0.25508517
149	STK38	0.25170459
150	PRKCE	0.23697577
151	CDK11A	0.23474424
152	FLT3	0.23381138
153	GRK7	0.22900114
154	DAPK3	0.22538328
155	ZAK	0.22290828

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.36734534
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.98677026
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.96950542
4	Ribosome_Homo sapiens_hsa03010	2.70590263
5	Olfactory transduction_Homo sapiens_hsa04740	2.68122264
6	Morphine addiction_Homo sapiens_hsa05032	2.42062179
7	Cocaine addiction_Homo sapiens_hsa05030	2.16311961
8	Amphetamine addiction_Homo sapiens_hsa05031	2.11310925
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10875747
10	Nicotine addiction_Homo sapiens_hsa05033	2.10386807
11	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.94311897
12	Circadian entrainment_Homo sapiens_hsa04713	1.90435866
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.89214821
14	GABAergic synapse_Homo sapiens_hsa04727	1.87506313
15	Cholinergic synapse_Homo sapiens_hsa04725	1.85045557
16	Phototransduction_Homo sapiens_hsa04744	1.84191198
17	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.78482209
18	Dopaminergic synapse_Homo sapiens_hsa04728	1.69332636
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67377444
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.66260496
21	Long-term potentiation_Homo sapiens_hsa04720	1.63764975
22	Serotonergic synapse_Homo sapiens_hsa04726	1.59448878
23	Insulin secretion_Homo sapiens_hsa04911	1.58428724
24	DNA replication_Homo sapiens_hsa03030	1.55554385
25	Long-term depression_Homo sapiens_hsa04730	1.53766685
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46955743
27	Taste transduction_Homo sapiens_hsa04742	1.46880491
28	Thyroid cancer_Homo sapiens_hsa05216	1.37378750
29	Other glycan degradation_Homo sapiens_hsa00511	1.35736463
30	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.33408749
31	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.32781594
32	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.31562828
33	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.30541309
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.28232577
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28183063
36	Homologous recombination_Homo sapiens_hsa03440	1.24360835
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20227103
38	Renin secretion_Homo sapiens_hsa04924	1.15743157
39	Alcoholism_Homo sapiens_hsa05034	1.10455237
40	Salivary secretion_Homo sapiens_hsa04970	1.09087495
41	Sphingolipid metabolism_Homo sapiens_hsa00600	1.07574154
42	Estrogen signaling pathway_Homo sapiens_hsa04915	1.07161168
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.06463743
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.04902239
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.03918360
46	Type II diabetes mellitus_Homo sapiens_hsa04930	0.98420763
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97996786
48	Purine metabolism_Homo sapiens_hsa00230	0.95813692
49	Gap junction_Homo sapiens_hsa04540	0.94311844
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93896654
51	Parkinsons disease_Homo sapiens_hsa05012	0.88427423
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86198796
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.85623133
54	Rap1 signaling pathway_Homo sapiens_hsa04015	0.85477625
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.84272924
56	Oocyte meiosis_Homo sapiens_hsa04114	0.83870564
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82032684
58	Circadian rhythm_Homo sapiens_hsa04710	0.81506745
59	Gastric acid secretion_Homo sapiens_hsa04971	0.78422244
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77645611
61	Oxidative phosphorylation_Homo sapiens_hsa00190	0.77387626
62	Basal transcription factors_Homo sapiens_hsa03022	0.74245606
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74158321
64	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.72626784
65	Glioma_Homo sapiens_hsa05214	0.71095328
66	Bile secretion_Homo sapiens_hsa04976	0.70921621
67	Regulation of autophagy_Homo sapiens_hsa04140	0.70829711
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.70777879
69	Melanogenesis_Homo sapiens_hsa04916	0.69354653
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.67564184
71	Tight junction_Homo sapiens_hsa04530	0.66164800
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64650797
73	Alzheimers disease_Homo sapiens_hsa05010	0.64072495
74	RNA polymerase_Homo sapiens_hsa03020	0.63828387
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.62239184
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.61919327
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61287619
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59776520
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59180917
80	Chemokine signaling pathway_Homo sapiens_hsa04062	0.58505416
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.57125886
82	Pancreatic secretion_Homo sapiens_hsa04972	0.56780881
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56657088
84	Sulfur relay system_Homo sapiens_hsa04122	0.55581322
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55561062
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.54962359
87	Butanoate metabolism_Homo sapiens_hsa00650	0.53674240
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.53470952
89	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.53306788
90	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.52135624
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51958127
92	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.51910644
93	Prion diseases_Homo sapiens_hsa05020	0.51534020
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.50997928
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.50230121
96	African trypanosomiasis_Homo sapiens_hsa05143	0.48886538
97	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.48703830
98	ErbB signaling pathway_Homo sapiens_hsa04012	0.48240281
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47392713
100	Base excision repair_Homo sapiens_hsa03410	0.46564449
101	Asthma_Homo sapiens_hsa05310	0.46127060
102	Platelet activation_Homo sapiens_hsa04611	0.45457640
103	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45170658
104	Malaria_Homo sapiens_hsa05144	0.44645757
105	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44619030
106	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.44241803
107	Axon guidance_Homo sapiens_hsa04360	0.43799181
108	Mismatch repair_Homo sapiens_hsa03430	0.43776903
109	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.42384397
110	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39642777
111	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39607532
112	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.39524158
113	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38863852
114	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38685292
115	Ras signaling pathway_Homo sapiens_hsa04014	0.38403631
116	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.38074833
117	Allograft rejection_Homo sapiens_hsa05330	0.37667999
118	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37364909
119	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36914406
120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36896181
121	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36477565
122	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36129276
123	Hippo signaling pathway_Homo sapiens_hsa04390	0.36063867
124	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35697710
125	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35661675
126	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34781547
127	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.34557258
128	Histidine metabolism_Homo sapiens_hsa00340	0.34338520
129	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.34023994
130	Ether lipid metabolism_Homo sapiens_hsa00565	0.33673451
131	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33462355
132	Steroid biosynthesis_Homo sapiens_hsa00100	0.32514990
133	Selenocompound metabolism_Homo sapiens_hsa00450	0.31295366
134	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.27380488
135	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.27233992
136	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.25766892
137	Mineral absorption_Homo sapiens_hsa04978	0.22241463
138	Choline metabolism in cancer_Homo sapiens_hsa05231	0.19394725
139	Arginine biosynthesis_Homo sapiens_hsa00220	0.18609339
140	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.18352356
141	Nitrogen metabolism_Homo sapiens_hsa00910	0.18324233
142	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.17101573
143	Arginine and proline metabolism_Homo sapiens_hsa00330	0.16270663
144	VEGF signaling pathway_Homo sapiens_hsa04370	0.14338007

SYNDIG1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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