SYNE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57158390
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50769094
3locomotory exploration behavior (GO:0035641)5.34000431
4vocalization behavior (GO:0071625)5.19143684
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.13525459
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02758945
7synaptic vesicle exocytosis (GO:0016079)4.94417982
8neuronal action potential propagation (GO:0019227)4.83114421
9glutamate receptor signaling pathway (GO:0007215)4.72329165
10glutamate secretion (GO:0014047)4.70934955
11regulation of glutamate receptor signaling pathway (GO:1900449)4.59597353
12synaptic transmission, glutamatergic (GO:0035249)4.59499939
13neurotransmitter-gated ion channel clustering (GO:0072578)4.57363229
14synaptic vesicle maturation (GO:0016188)4.55023411
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.48871367
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41279441
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.39089435
18protein localization to synapse (GO:0035418)4.33703552
19neuron-neuron synaptic transmission (GO:0007270)4.31489128
20gamma-aminobutyric acid transport (GO:0015812)4.27526372
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.25302848
22cerebellar granule cell differentiation (GO:0021707)4.22027261
23regulation of synaptic vesicle exocytosis (GO:2000300)4.21471076
24cilium or flagellum-dependent cell motility (GO:0001539)4.13601874
25neuron cell-cell adhesion (GO:0007158)4.08281490
26cellular potassium ion homeostasis (GO:0030007)4.08232456
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.08232012
28neurotransmitter secretion (GO:0007269)4.07300234
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04440870
30long-term memory (GO:0007616)4.01862991
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.98754233
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.88717177
33regulation of neuronal synaptic plasticity (GO:0048168)3.88690487
34positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.85692772
35regulation of postsynaptic membrane potential (GO:0060078)3.84891997
36regulation of synapse structural plasticity (GO:0051823)3.84841955
37regulation of synaptic vesicle transport (GO:1902803)3.84408997
38exploration behavior (GO:0035640)3.79460912
39positive regulation of synapse maturation (GO:0090129)3.78052331
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76896649
41cerebellar Purkinje cell differentiation (GO:0021702)3.75789083
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71734312
43positive regulation of membrane potential (GO:0045838)3.71494468
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.71093058
45transmission of nerve impulse (GO:0019226)3.61318171
46sodium ion export (GO:0071436)3.54816189
47long-term synaptic potentiation (GO:0060291)3.54627996
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50011850
49presynaptic membrane assembly (GO:0097105)3.49756448
50regulation of synaptic plasticity (GO:0048167)3.49702628
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.43389734
52neurotransmitter transport (GO:0006836)3.36742153
53presynaptic membrane organization (GO:0097090)3.36362390
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36309997
55negative regulation of cell killing (GO:0031342)3.36309997
56membrane depolarization during action potential (GO:0086010)3.36133986
57membrane depolarization (GO:0051899)3.33529686
58response to histamine (GO:0034776)3.30606653
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27276885
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26456007
61regulation of dendritic spine morphogenesis (GO:0061001)3.25507236
62cell communication by electrical coupling (GO:0010644)3.23572968
63L-amino acid import (GO:0043092)3.22053199
64long term synaptic depression (GO:0060292)3.21294925
65postsynaptic membrane organization (GO:0001941)3.20444622
66regulation of neurotransmitter secretion (GO:0046928)3.19426328
67regulation of voltage-gated calcium channel activity (GO:1901385)3.18815708
68membrane hyperpolarization (GO:0060081)3.18666876
69regulation of vesicle fusion (GO:0031338)3.15482440
70regulation of synapse maturation (GO:0090128)3.14388383
71neuromuscular process controlling balance (GO:0050885)3.13873326
72positive regulation of potassium ion transmembrane transport (GO:1901381)3.13484102
73regulation of neurotransmitter levels (GO:0001505)3.13225774
74cellular response to epinephrine stimulus (GO:0071872)3.12679336
75auditory behavior (GO:0031223)3.10870732
76proline transport (GO:0015824)3.10647753
77synaptic vesicle endocytosis (GO:0048488)3.10626425
78regulation of B cell receptor signaling pathway (GO:0050855)3.09716309
79layer formation in cerebral cortex (GO:0021819)3.06099745
80neuron recognition (GO:0008038)3.04459739
81neuromuscular process controlling posture (GO:0050884)3.01695320
82dendritic spine morphogenesis (GO:0060997)3.01598622
83cell differentiation in hindbrain (GO:0021533)3.01104200
84activation of protein kinase A activity (GO:0034199)3.01026937
85response to auditory stimulus (GO:0010996)2.99563452
86learning (GO:0007612)2.99474157
87fear response (GO:0042596)2.97950247
88behavioral fear response (GO:0001662)2.97475692
89behavioral defense response (GO:0002209)2.97475692
90positive T cell selection (GO:0043368)2.96256220
91regulation of ARF protein signal transduction (GO:0032012)2.96192420
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94378188
93regulation of neurotransmitter transport (GO:0051588)2.94307837
94synaptic transmission (GO:0007268)2.92321632
95detection of calcium ion (GO:0005513)2.91634015
96adult walking behavior (GO:0007628)2.91231632
97potassium ion import (GO:0010107)2.91112937
98mechanosensory behavior (GO:0007638)2.89357122
99regulation of synaptic transmission (GO:0050804)2.89296116
100startle response (GO:0001964)2.89275240
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88263781
102positive regulation of synaptic transmission (GO:0050806)2.87454156
103positive regulation of neurotransmitter secretion (GO:0001956)2.86531828
104behavioral response to cocaine (GO:0048148)2.85370406
105axonal fasciculation (GO:0007413)2.85256800
106synapse assembly (GO:0007416)2.84966147
107glycine transport (GO:0015816)2.84468396
108positive regulation of gamma-delta T cell activation (GO:0046645)2.84154051
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83953599
110response to epinephrine (GO:0071871)2.83708352
111regulation of female receptivity (GO:0045924)2.82969562
112phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82500497
113regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82184790
114regulation of gamma-delta T cell differentiation (GO:0045586)2.80965541
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76449598
116cilium movement (GO:0003341)2.75925842
117activated T cell proliferation (GO:0050798)2.71720474
118cellular response to ethanol (GO:0071361)2.68314934
119negative regulation of type 2 immune response (GO:0002829)2.67777490
120positive thymic T cell selection (GO:0045059)2.67774156
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64243635
122interkinetic nuclear migration (GO:0022027)2.60276228
123negative regulation of inclusion body assembly (GO:0090084)2.57253339
124axonemal dynein complex assembly (GO:0070286)2.54814835
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54186477
126microglial cell activation (GO:0001774)2.54135506
127phospholipid translocation (GO:0045332)2.52769333
128lipid translocation (GO:0034204)2.52769333
129negative T cell selection (GO:0043383)2.49892633
130regulation of gamma-delta T cell activation (GO:0046643)2.49338274
131positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47108480
132cellular response to interleukin-15 (GO:0071350)2.46869779
133nerve growth factor signaling pathway (GO:0038180)2.41781581
134positive regulation of Rap GTPase activity (GO:0032854)2.38705840
135macroautophagy (GO:0016236)2.38418173
136negative thymic T cell selection (GO:0045060)2.35730763
137regulation of Rap GTPase activity (GO:0032317)2.33976632
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32446308
139positive regulation of phosphatase activity (GO:0010922)2.31660057
140regulation of beta-amyloid formation (GO:1902003)2.31618712
141growth hormone receptor signaling pathway (GO:0060396)2.31579101
142response to interleukin-15 (GO:0070672)2.31146500
143regulation of isotype switching to IgG isotypes (GO:0048302)2.30331743
144striated muscle atrophy (GO:0014891)2.28786969
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25146041
146regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.24709994
147establishment of protein localization to Golgi (GO:0072600)2.23135415
148negative regulation of immunoglobulin mediated immune response (GO:0002890)2.22190826
149negative regulation of B cell mediated immunity (GO:0002713)2.22190826
150import into cell (GO:0098657)2.20539344
151cellular response to catecholamine stimulus (GO:0071870)2.20228424
152cellular response to monoamine stimulus (GO:0071868)2.20228424
153* nucleus localization (GO:0051647)2.19712765
154cellular response to growth hormone stimulus (GO:0071378)2.17079886
155motile cilium assembly (GO:0044458)2.16721819
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.16682055
157regulation of germinal center formation (GO:0002634)2.16100431
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.15776041
159B cell receptor signaling pathway (GO:0050853)2.15005806
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14985921
161macrophage activation involved in immune response (GO:0002281)2.14631201
162regulation of calcium ion transmembrane transporter activity (GO:1901019)2.13190897
163regulation of calcium ion transmembrane transport (GO:1903169)2.13190897
164protein K48-linked deubiquitination (GO:0071108)2.12898472
165relaxation of cardiac muscle (GO:0055119)2.12503411
166negative regulation of neurotransmitter transport (GO:0051589)2.11354034
167protein K11-linked deubiquitination (GO:0035871)2.11101628
168negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.10835858
169cyclic nucleotide catabolic process (GO:0009214)2.10069398
170skeletal muscle adaptation (GO:0043501)2.09965025
171peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.09196737
172regulation of cell communication by electrical coupling (GO:0010649)2.09078631
173cellular extravasation (GO:0045123)2.08543047
174response to catecholamine (GO:0071869)2.04611776
175response to monoamine (GO:0071867)2.04611776
176positive regulation of cation channel activity (GO:2001259)2.04177424
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.03945775
178regulation of skeletal muscle cell differentiation (GO:2001014)2.03352676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45943174
2GBX2_23144817_ChIP-Seq_PC3_Human3.83468010
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12699690
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02679991
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88401982
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61051900
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61051900
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55500696
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55305125
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47653695
11DROSHA_22980978_ChIP-Seq_HELA_Human2.47021100
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46805391
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43714714
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43135365
15REST_21632747_ChIP-Seq_MESCs_Mouse2.40260527
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38018002
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34025976
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.29884381
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.29081873
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.28501660
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13636524
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.09694475
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05714122
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03943919
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00678530
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94446933
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.90906897
28AR_21572438_ChIP-Seq_LNCaP_Human1.90902195
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84164208
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82969103
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81173986
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79723284
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.76939585
34RUNX_20019798_ChIP-Seq_JUKART_Human1.76649695
35TAF15_26573619_Chip-Seq_HEK293_Human1.68257624
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64459618
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57760957
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56122002
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55905603
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53327810
41P300_19829295_ChIP-Seq_ESCs_Human1.50128845
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.48963504
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.42845036
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41981827
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41368741
46* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40465831
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37390190
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.37358175
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37062709
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36081920
51AR_25329375_ChIP-Seq_VCAP_Human1.34599639
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34255008
53* STAT3_23295773_ChIP-Seq_U87_Human1.33924790
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33090059
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.31867022
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.31558410
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31009579
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.30970261
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24773191
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23961243
61* AR_19668381_ChIP-Seq_PC3_Human1.23801083
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23387878
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23283368
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.22128875
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21975379
66* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21376182
67* TCF4_23295773_ChIP-Seq_U87_Human1.20420304
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.19900922
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.19457343
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19241794
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18841924
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18533536
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.18143605
74* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16505570
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15103047
76* TP53_16413492_ChIP-PET_HCT116_Human1.14892089
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14797275
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14262807
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13621484
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13515789
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12620996
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.12601717
83AHR_22903824_ChIP-Seq_MCF-7_Human1.12570047
84ZNF274_21170338_ChIP-Seq_K562_Hela1.12476674
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09850846
86* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09328111
87BCAT_22108803_ChIP-Seq_LS180_Human1.07776768
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07242572
89* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06747880
90* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06747880
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06441911
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06147918
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05728197
94VDR_24787735_ChIP-Seq_THP-1_Human1.04579602
95RXR_22108803_ChIP-Seq_LS180_Human1.03692634
96KDM2B_26808549_Chip-Seq_REH_Human1.03529919
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03315733
98GATA1_22025678_ChIP-Seq_K562_Human1.03268943
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03144727
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.02685911
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02328863
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01322358
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01043786
104* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99982116
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99510594
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99473934
107FUS_26573619_Chip-Seq_HEK293_Human0.99282512
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.98977662
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98517974
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98517974
111* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98320942
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98290229
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98225130
114* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97845650
115TP53_18474530_ChIP-ChIP_U2OS_Human0.96677808
116RNF2_27304074_Chip-Seq_NSC_Mouse0.96304433
117ER_23166858_ChIP-Seq_MCF-7_Human0.96108391
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95919321
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95901028
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.95500178
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95026190
122* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94864770
123* EZH2_27294783_Chip-Seq_NPCs_Mouse0.94705552
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.94467759
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93497070
126P53_22387025_ChIP-Seq_ESCs_Mouse0.92551001
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.92422780
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91634893
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91112750
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89976397
131* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89249506
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.88807008
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88329366
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.88063092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22509444
2MP0003880_abnormal_central_pattern4.79490726
3MP0003635_abnormal_synaptic_transmissio4.13426719
4MP0009046_muscle_twitch3.74342653
5MP0009745_abnormal_behavioral_response3.54769356
6MP0004270_analgesia3.33219890
7MP0002064_seizures3.27399071
8MP0002063_abnormal_learning/memory/cond3.24440204
9MP0001968_abnormal_touch/_nociception2.93173840
10MP0002572_abnormal_emotion/affect_behav2.88552500
11MP0002272_abnormal_nervous_system2.81122083
12MP0002822_catalepsy2.72247729
13MP0001486_abnormal_startle_reflex2.67689262
14MP0005423_abnormal_somatic_nervous2.53279200
15MP0001501_abnormal_sleep_pattern2.52248345
16MP0004130_abnormal_muscle_cell2.50005579
17MP0002734_abnormal_mechanical_nocicepti2.46400352
18MP0002736_abnormal_nociception_after2.41254632
19MP0002735_abnormal_chemical_nociception2.36811748
20MP0001958_emphysema2.33529412
21MP0008569_lethality_at_weaning2.27203424
22MP0002067_abnormal_sensory_capabilities2.20603230
23* MP0001440_abnormal_grooming_behavior2.20408612
24MP0003724_increased_susceptibility_to2.00261887
25MP0003763_abnormal_thymus_physiology1.95022034
26MP0009780_abnormal_chondrocyte_physiolo1.90533657
27MP0001970_abnormal_pain_threshold1.86901567
28MP0002733_abnormal_thermal_nociception1.82130123
29MP0005646_abnormal_pituitary_gland1.79068616
30MP0005386_behavior/neurological_phenoty1.74446121
31MP0004924_abnormal_behavior1.74446121
32MP0002184_abnormal_innervation1.68212257
33MP0002557_abnormal_social/conspecific_i1.67483829
34MP0004145_abnormal_muscle_electrophysio1.66115508
35MP0003329_amyloid_beta_deposits1.61213191
36MP0002909_abnormal_adrenal_gland1.58698841
37MP0003879_abnormal_hair_cell1.55713661
38MP0000778_abnormal_nervous_system1.50535838
39MP0003633_abnormal_nervous_system1.49703226
40MP0004858_abnormal_nervous_system1.49379999
41MP0001502_abnormal_circadian_rhythm1.47634114
42MP0001984_abnormal_olfaction1.44200555
43MP0000955_abnormal_spinal_cord1.39126357
44MP0000751_myopathy1.38960601
45MP0004811_abnormal_neuron_physiology1.38613027
46* MP0002066_abnormal_motor_capabilities/c1.38387920
47MP0004142_abnormal_muscle_tone1.37935557
48MP0004885_abnormal_endolymph1.36938016
49MP0004883_abnormal_blood_vessel1.35047680
50MP0003690_abnormal_glial_cell1.34186870
51MP0003303_peritoneal_inflammation1.34132545
52* MP0002882_abnormal_neuron_morphology1.33098172
53MP0006276_abnormal_autonomic_nervous1.31886504
54MP0000015_abnormal_ear_pigmentation1.31792288
55MP0004084_abnormal_cardiac_muscle1.31597358
56MP0001188_hyperpigmentation1.30198709
57MP0003091_abnormal_cell_migration1.29652128
58MP0005551_abnormal_eye_electrophysiolog1.28596710
59MP0004215_abnormal_myocardial_fiber1.26964094
60* MP0005388_respiratory_system_phenotype1.25527647
61* MP0002133_abnormal_respiratory_system1.25527647
62MP0003631_nervous_system_phenotype1.24811062
63MP0002837_dystrophic_cardiac_calcinosis1.24738813
64MP0004381_abnormal_hair_follicle1.23911362
65MP0003828_pulmonary_edema1.23826790
66MP0002168_other_aberrant_phenotype1.22193829
67MP0003950_abnormal_plasma_membrane1.20947776
68MP0003787_abnormal_imprinting1.18667974
69MP0005503_abnormal_tendon_morphology1.14118383
70MP0005174_abnormal_tail_pigmentation1.13366054
71MP0001835_abnormal_antigen_presentation1.11142224
72MP0002229_neurodegeneration1.08341705
73MP0001800_abnormal_humoral_immune1.07950456
74MP0001529_abnormal_vocalization1.04091527
75MP0004742_abnormal_vestibular_system1.03099788
76MP0001905_abnormal_dopamine_level1.02882730
77MP0006082_CNS_inflammation1.01843645
78MP0003279_aneurysm1.01691011
79MP0003300_gastrointestinal_ulcer1.01412567
80MP0002152_abnormal_brain_morphology1.00750858
81MP0008872_abnormal_physiological_respon1.00671201
82MP0005645_abnormal_hypothalamus_physiol0.98692605
83MP0008874_decreased_physiological_sensi0.98025022
84MP0005164_abnormal_response_to0.97569633
85* MP0004085_abnormal_heartbeat0.96051924
86MP0005275_abnormal_skin_tensile0.95558006
87MP0000920_abnormal_myelination0.94597690
88MP0003632_abnormal_nervous_system0.93049587
89MP0002998_abnormal_bone_remodeling0.92235344
90MP0005595_abnormal_vascular_smooth0.91572134
91MP0001986_abnormal_taste_sensitivity0.90547172
92MP0004484_altered_response_of0.88838123
93MP0005409_darkened_coat_color0.88784972
94MP0005171_absent_coat_pigmentation0.88766672
95MP0001963_abnormal_hearing_physiology0.88034898
96MP0004043_abnormal_pH_regulation0.86422826
97MP0003172_abnormal_lysosome_physiology0.85910018
98MP0002090_abnormal_vision0.85819178
99MP0003866_abnormal_defecation0.85380481
100MP0005671_abnormal_response_to0.84348769
101MP0003656_abnormal_erythrocyte_physiolo0.84093628
102MP0010386_abnormal_urinary_bladder0.83197941
103MP0002876_abnormal_thyroid_physiology0.83010401
104MP0002295_abnormal_pulmonary_circulatio0.82735894
105MP0000013_abnormal_adipose_tissue0.82555975
106* MP0002069_abnormal_eating/drinking_beha0.81852939
107MP0005535_abnormal_body_temperature0.80523900
108MP0003075_altered_response_to0.79679040
109MP0000465_gastrointestinal_hemorrhage0.79535455
110MP0003634_abnormal_glial_cell0.79461167
111MP0001485_abnormal_pinna_reflex0.79432355
112MP0000569_abnormal_digit_pigmentation0.78627210
113MP0004510_myositis0.78312883
114* MP0003137_abnormal_impulse_conducting0.77851838
115MP0008057_abnormal_DNA_replication0.77828457
116MP0002638_abnormal_pupillary_reflex0.76837381
117MP0003122_maternal_imprinting0.74385477
118MP0002723_abnormal_immune_serum0.73701741
119MP0002405_respiratory_system_inflammati0.72690846
120MP0005167_abnormal_blood-brain_barrier0.72237992
121MP0002419_abnormal_innate_immunity0.72217190
122MP0005310_abnormal_salivary_gland0.71997037
123MP0005387_immune_system_phenotype0.71922077
124MP0001790_abnormal_immune_system0.71922077
125MP0002420_abnormal_adaptive_immunity0.71521783
126MP0003045_fibrosis0.70440473
127* MP0002752_abnormal_somatic_nervous0.69984077
128MP0002108_abnormal_muscle_morphology0.69688752
129MP0001299_abnormal_eye_distance/0.69194124
130MP0004036_abnormal_muscle_relaxation0.67612188
131MP0000604_amyloidosis0.67386943
132MP0006072_abnormal_retinal_apoptosis0.66550939
133MP0004147_increased_porphyrin_level0.66494152
134MP0003646_muscle_fatigue0.64097026
135MP0000747_muscle_weakness0.64071337
136MP0005623_abnormal_meninges_morphology0.62946937
137* MP0001177_atelectasis0.61322757
138MP0004233_abnormal_muscle_weight0.59714385
139MP0005620_abnormal_muscle_contractility0.59656355
140MP0000749_muscle_degeneration0.58232859
141MP0003183_abnormal_peptide_metabolism0.57065504
142MP0001664_abnormal_digestion0.55066368

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.29409096
2Myokymia (HP:0002411)6.12955428
3Focal seizures (HP:0007359)5.85722033
4Epileptic encephalopathy (HP:0200134)5.30039739
5Progressive cerebellar ataxia (HP:0002073)5.23286372
6Atonic seizures (HP:0010819)5.11373975
7Febrile seizures (HP:0002373)4.96845661
8Visual hallucinations (HP:0002367)4.70371741
9Action tremor (HP:0002345)4.54673224
10Gaze-evoked nystagmus (HP:0000640)4.43189256
11Absence seizures (HP:0002121)4.22177291
12Broad-based gait (HP:0002136)4.04248586
13Dialeptic seizures (HP:0011146)4.01388751
14Scanning speech (HP:0002168)3.98987036
15Dysdiadochokinesis (HP:0002075)3.97099553
16Hyperventilation (HP:0002883)3.91836327
17Generalized tonic-clonic seizures (HP:0002069)3.83153282
18Dysmetria (HP:0001310)3.63806576
19Impaired smooth pursuit (HP:0007772)3.54947629
20Dysmetric saccades (HP:0000641)3.52235026
21Genetic anticipation (HP:0003743)3.47641550
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.40898544
23Truncal ataxia (HP:0002078)3.39404509
24Abnormal respiratory epithelium morphology (HP:0012253)3.21915001
25Abnormal respiratory motile cilium morphology (HP:0005938)3.21915001
26Hemiplegia (HP:0002301)3.19582319
27Poor eye contact (HP:0000817)3.17919941
28Rhinitis (HP:0012384)3.14682151
29T lymphocytopenia (HP:0005403)3.10341309
30Abnormality of ocular smooth pursuit (HP:0000617)3.05056929
31Impaired vibration sensation in the lower limbs (HP:0002166)3.04927072
32Aortic aneurysm (HP:0004942)3.04892753
33Hemiparesis (HP:0001269)3.02578791
34Impaired social interactions (HP:0000735)2.94359960
35Abnormal social behavior (HP:0012433)2.94359960
36Abnormality of T cell number (HP:0011839)2.93247104
37Abnormality of binocular vision (HP:0011514)2.92428326
38Diplopia (HP:0000651)2.92428326
39Postural instability (HP:0002172)2.89828256
40Depression (HP:0000716)2.89276277
41Abnormality of the lower motor neuron (HP:0002366)2.87880329
42Supranuclear gaze palsy (HP:0000605)2.85975945
43Abnormal eating behavior (HP:0100738)2.84814156
44Intention tremor (HP:0002080)2.77947421
45Anxiety (HP:0000739)2.75496405
46Amblyopia (HP:0000646)2.73843904
47Status epilepticus (HP:0002133)2.72814084
48Urinary bladder sphincter dysfunction (HP:0002839)2.71520826
49Ventricular fibrillation (HP:0001663)2.67644138
50Nasal polyposis (HP:0100582)2.66580822
51Excessive salivation (HP:0003781)2.63706088
52Drooling (HP:0002307)2.63706088
53Bronchiectasis (HP:0002110)2.53776942
54Epileptiform EEG discharges (HP:0011182)2.44990474
55Eczematoid dermatitis (HP:0000976)2.42271212
56Abnormality of saccadic eye movements (HP:0000570)2.41778573
57Recurrent bronchitis (HP:0002837)2.38388187
58Abnormality of the nasal mucosa (HP:0000433)2.37715247
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36262351
60Hyporeflexia of lower limbs (HP:0002600)2.36198299
61Protruding tongue (HP:0010808)2.35801527
62Stereotypic behavior (HP:0000733)2.35667764
63Abnormal ciliary motility (HP:0012262)2.34287514
64Ankle clonus (HP:0011448)2.31646617
65Spontaneous hematomas (HP:0007420)2.31321831
66Hyperkalemia (HP:0002153)2.29319550
67Impaired vibratory sensation (HP:0002495)2.28217029
68Absent frontal sinuses (HP:0002688)2.27249163
69Spastic gait (HP:0002064)2.26397117
70Syncope (HP:0001279)2.24312358
71Ocular albinism (HP:0001107)2.24171148
72Prolonged QT interval (HP:0001657)2.22069334
73Blue irides (HP:0000635)2.20086057
74Bradykinesia (HP:0002067)2.19609723
75Obstructive sleep apnea (HP:0002870)2.17903300
76Stomach cancer (HP:0012126)2.17890434
77Abnormal respiratory motile cilium physiology (HP:0012261)2.15732821
78Urinary urgency (HP:0000012)2.15673898
79EEG with generalized epileptiform discharges (HP:0011198)2.13616211
80Absent speech (HP:0001344)2.13173958
81Abnormality of the fingertips (HP:0001211)2.13098145
82Hypoplasia of the iris (HP:0007676)2.12920228
83Aortic dissection (HP:0002647)2.12800273
84Glucose intolerance (HP:0000833)2.10554644
85Fetal akinesia sequence (HP:0001989)2.08906083
86Annular pancreas (HP:0001734)2.08376054
87Gait ataxia (HP:0002066)2.03938001
88Incomplete penetrance (HP:0003829)2.02673360
89Gastrointestinal infarctions (HP:0005244)2.01857764
90Exercise-induced myalgia (HP:0003738)2.01530915
91Recurrent bacterial skin infections (HP:0005406)2.01442827
92Aplasia involving bones of the upper limbs (HP:0009823)2.01315781
93Aplasia of the phalanges of the hand (HP:0009802)2.01315781
94Aplasia involving bones of the extremities (HP:0009825)2.01315781
95Chronic hepatic failure (HP:0100626)2.01066451
96Difficulty running (HP:0009046)2.01057497
97Muscle fiber splitting (HP:0003555)2.00510431
98Recurrent abscess formation (HP:0002722)1.99600167
99Abnormal EKG (HP:0003115)1.99574011
100Generalized hypopigmentation of hair (HP:0011358)1.99356608
101Absent/shortened dynein arms (HP:0200106)1.99335242
102Dynein arm defect of respiratory motile cilia (HP:0012255)1.99335242
103Cerebral aneurysm (HP:0004944)1.98604909
104Iris hypopigmentation (HP:0007730)1.97894727
105Neurofibrillary tangles (HP:0002185)1.96107055
106Bronchitis (HP:0012387)1.95072361
107Progressive inability to walk (HP:0002505)1.93989627
108Hypsarrhythmia (HP:0002521)1.93978901
109Overgrowth (HP:0001548)1.92852338
110Abnormality of the corticospinal tract (HP:0002492)1.91619875
111Generalized myoclonic seizures (HP:0002123)1.90350352
112Pheochromocytoma (HP:0002666)1.86849881
113Cerebral inclusion bodies (HP:0100314)1.86201421
114Interstitial pulmonary disease (HP:0006530)1.86030632
115Abnormality of incisor morphology (HP:0011063)1.85380372
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85076988
117Decreased circulating renin level (HP:0003351)1.84505885
118Torticollis (HP:0000473)1.83771876
119Widely spaced teeth (HP:0000687)1.83202014
120Atrial fibrillation (HP:0005110)1.82978672
121Inability to walk (HP:0002540)1.82864611
122Retinal dysplasia (HP:0007973)1.82259697
123Postural tremor (HP:0002174)1.81954040
124Limb ataxia (HP:0002070)1.81527564
125Subacute progressive viral hepatitis (HP:0006572)1.79703466
126Psychosis (HP:0000709)1.79501643
127Bundle branch block (HP:0011710)1.79316753
128Lower limb muscle weakness (HP:0007340)1.79283574
129Chronic otitis media (HP:0000389)1.78944857
130Neoplasm of the heart (HP:0100544)1.78130225
131Primary atrial arrhythmia (HP:0001692)1.77203267
132Bradycardia (HP:0001662)1.76933742
133Striae distensae (HP:0001065)1.76418427
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.76263802
135Abnormality of salivation (HP:0100755)1.76189816
136Myositis (HP:0100614)1.75101738
137Focal dystonia (HP:0004373)1.74079690
138Spinal canal stenosis (HP:0003416)1.73735935
139Abnormality of eosinophils (HP:0001879)1.73686047
140Confusion (HP:0001289)1.73485982
141Sudden death (HP:0001699)1.73145283
142Megalencephaly (HP:0001355)1.72701996
143Arterial tortuosity (HP:0005116)1.71920959
144Gingivitis (HP:0000230)1.71294026
145Neuronal loss in central nervous system (HP:0002529)1.71061946
146Papilledema (HP:0001085)1.70972688
147Slow saccadic eye movements (HP:0000514)1.70927415
148Mutism (HP:0002300)1.70730846
149Retrobulbar optic neuritis (HP:0100654)1.69146239
150Optic neuritis (HP:0100653)1.69146239
151Peritonitis (HP:0002586)1.68118336
152Vascular tortuosity (HP:0004948)1.67574847
153Truncal obesity (HP:0001956)1.66950604
154Recurrent gram-negative bacterial infections (HP:0005420)1.66142108
155Abnormal glucose tolerance (HP:0001952)1.64267621
156Hematochezia (HP:0002573)1.63952594
157Thyroiditis (HP:0100646)1.62890429
158Hypokalemic alkalosis (HP:0001949)1.59815449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80720862
2NTRK34.79888198
3FRK3.61573695
4CASK2.93864595
5MAP3K92.82465875
6TNIK2.67475981
7MAP3K42.66629500
8DAPK22.41781486
9MAP2K72.41157331
10NTRK22.23266092
11RIPK42.08987906
12MINK12.06619372
13CAMKK21.84244159
14PRPF4B1.77094655
15MAP2K41.71338483
16JAK11.71326073
17CDK191.68043364
18CAMKK11.66775705
19PAK61.66724571
20TAOK31.59696067
21MAP3K121.59312190
22KSR21.56200356
23BLK1.55264809
24FGFR21.54496716
25MARK11.52829692
26STK381.47209612
27PNCK1.43015948
28DAPK11.42444856
29PIK3CG1.42429669
30TXK1.42276964
31FES1.38964967
32PRKD31.38890894
33CDK51.38086602
34NTRK11.36337169
35TRPM71.35991491
36PLK21.35708745
37FGFR31.35616992
38MAP3K131.35007732
39KSR11.33574688
40PRKCG1.28497813
41SGK21.26377879
42OBSCN1.25466268
43CAMK11.22234423
44CAMK2A1.19603374
45CSK1.19513346
46SGK4941.19038106
47SGK2231.19038106
48GRK51.17917593
49MAPK131.17755247
50PTK2B1.13700466
51TGFBR21.12859694
52OXSR11.12060354
53SIK21.11794962
54CAMK2B1.11298799
55MARK21.10949726
56TTN1.08000168
57EPHA31.06464342
58PIK3CA1.06139798
59SYK1.04565925
60SGK31.02426731
61WNK11.01823228
62NLK0.99959805
63BMPR20.99261845
64GRK60.97441835
65MAP3K20.96642524
66IKBKE0.94773116
67TYK20.94280998
68ITK0.94241877
69BTK0.93955918
70ZAP700.93883289
71MAP4K10.93725323
72PHKG10.92491627
73PHKG20.92491627
74ARAF0.91532420
75PDGFRB0.91090146
76PRKCH0.89505218
77TEC0.88079408
78MAPK150.87951930
79SGK10.87335295
80AKT30.85208732
81PINK10.84560577
82STK110.83595367
83HCK0.82923370
84CAMK1G0.77444692
85TYRO30.76719208
86EPHB10.76299194
87MAP3K70.76052722
88MYLK0.76000041
89CAMK2D0.75545644
90LCK0.73502424
91MUSK0.73123196
92NEK60.72757298
93SIK30.72336104
94UHMK10.71435942
95CDK180.71344040
96INSRR0.71136281
97CDK150.68458643
98TNK20.67872229
99PDPK10.67746448
100CDC42BPA0.66450626
101JAK20.66325267
102CAMK40.66298307
103CAMK2G0.65947054
104JAK30.65176862
105PRKCE0.65155014
106PDK10.64652662
107DYRK1A0.64007191
108LMTK20.63027463
109RAF10.61773593
110RIPK10.60672994
111ERBB20.60551799
112CDK140.59074627
113PRKD10.58362757
114CDK11A0.57151019
115NEK90.56694145
116MAPK120.56533649
117FGR0.55977141
118RPS6KA30.55649085
119RET0.55152950
120ADRBK10.53977204
121MAP3K60.53236862
122PRKAA20.53225298
123PRKCQ0.52746886
124MAP2K30.52197970
125PAK30.51734393
126MELK0.51196698
127ACVR1B0.50574158
128PIM10.50310125
129MARK30.49982411
130FYN0.47853741
131DMPK0.47704244
132PRKG10.46272801
133KIT0.46093662
134MAP3K10.45652740
135HIPK20.45364026
136ROCK20.45343242
137CDK30.44951057
138MAPK70.44722452
139* PRKACA0.41635027
140CCNB10.40900433
141PRKCA0.38621351
142MAPK100.38385084
143GRK70.37141805
144PRKCB0.36404926
145PRKACB0.35416110
146NME10.34573534
147TAOK10.34037526

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14663624
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88472669
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81730837
4Glutamatergic synapse_Homo sapiens_hsa047242.81265691
5Circadian entrainment_Homo sapiens_hsa047132.81033731
6Long-term potentiation_Homo sapiens_hsa047202.76104486
7GABAergic synapse_Homo sapiens_hsa047272.65628165
8Morphine addiction_Homo sapiens_hsa050322.57512626
9Olfactory transduction_Homo sapiens_hsa047402.52183631
10Amphetamine addiction_Homo sapiens_hsa050312.45537502
11Salivary secretion_Homo sapiens_hsa049702.32563929
12Insulin secretion_Homo sapiens_hsa049112.04556245
13Taste transduction_Homo sapiens_hsa047422.01243260
14Dopaminergic synapse_Homo sapiens_hsa047281.97080464
15Long-term depression_Homo sapiens_hsa047301.91350484
16Gastric acid secretion_Homo sapiens_hsa049711.88963411
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81738321
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81592171
19Calcium signaling pathway_Homo sapiens_hsa040201.81105640
20Cholinergic synapse_Homo sapiens_hsa047251.75464247
21Renin secretion_Homo sapiens_hsa049241.73479007
22Oxytocin signaling pathway_Homo sapiens_hsa049211.68049115
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63582568
24Serotonergic synapse_Homo sapiens_hsa047261.59592748
25Cocaine addiction_Homo sapiens_hsa050301.53461736
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51445719
27cAMP signaling pathway_Homo sapiens_hsa040241.44305076
28Collecting duct acid secretion_Homo sapiens_hsa049661.38164516
29GnRH signaling pathway_Homo sapiens_hsa049121.36389234
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34859533
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34214429
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31084180
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24160265
34Type II diabetes mellitus_Homo sapiens_hsa049301.22699550
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21449325
36Cardiac muscle contraction_Homo sapiens_hsa042601.17572644
37Gap junction_Homo sapiens_hsa045401.17102370
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12958661
39Pancreatic secretion_Homo sapiens_hsa049721.10449808
40Phototransduction_Homo sapiens_hsa047441.07612917
41T cell receptor signaling pathway_Homo sapiens_hsa046601.05672495
42B cell receptor signaling pathway_Homo sapiens_hsa046621.05117058
43ABC transporters_Homo sapiens_hsa020101.05035495
44Osteoclast differentiation_Homo sapiens_hsa043801.05004817
45Dilated cardiomyopathy_Homo sapiens_hsa054141.03096553
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02723758
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.02148416
48Estrogen signaling pathway_Homo sapiens_hsa049151.00049624
49Nitrogen metabolism_Homo sapiens_hsa009100.97114680
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96451321
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94388903
52Axon guidance_Homo sapiens_hsa043600.94100863
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.87904201
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87371237
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87045798
56Circadian rhythm_Homo sapiens_hsa047100.86625764
57Melanogenesis_Homo sapiens_hsa049160.84807984
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83851424
59Non-small cell lung cancer_Homo sapiens_hsa052230.83205557
60Thyroid hormone synthesis_Homo sapiens_hsa049180.83068618
61FoxO signaling pathway_Homo sapiens_hsa040680.82718495
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.81805805
63Glioma_Homo sapiens_hsa052140.80693736
64Focal adhesion_Homo sapiens_hsa045100.80358805
65Dorso-ventral axis formation_Homo sapiens_hsa043200.79724568
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.77385832
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76264442
68Graft-versus-host disease_Homo sapiens_hsa053320.75529324
69ErbB signaling pathway_Homo sapiens_hsa040120.75363876
70Vibrio cholerae infection_Homo sapiens_hsa051100.74836144
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74615486
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73345785
73Inositol phosphate metabolism_Homo sapiens_hsa005620.72740773
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71666865
75Prolactin signaling pathway_Homo sapiens_hsa049170.70118977
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68850332
77Malaria_Homo sapiens_hsa051440.68832044
78Leishmaniasis_Homo sapiens_hsa051400.67555582
79MAPK signaling pathway_Homo sapiens_hsa040100.67285716
80Endometrial cancer_Homo sapiens_hsa052130.66891749
81Renal cell carcinoma_Homo sapiens_hsa052110.65369872
82Histidine metabolism_Homo sapiens_hsa003400.65229003
83Choline metabolism in cancer_Homo sapiens_hsa052310.65073882
84ECM-receptor interaction_Homo sapiens_hsa045120.64608219
85Linoleic acid metabolism_Homo sapiens_hsa005910.63475217
86Bile secretion_Homo sapiens_hsa049760.63327266
87Staphylococcus aureus infection_Homo sapiens_hsa051500.62522658
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.61891143
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61685303
90Toxoplasmosis_Homo sapiens_hsa051450.60971480
91Amoebiasis_Homo sapiens_hsa051460.60448567
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60305601
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59694902
94Insulin resistance_Homo sapiens_hsa049310.59541899
95Primary immunodeficiency_Homo sapiens_hsa053400.58456662
96Ether lipid metabolism_Homo sapiens_hsa005650.58235201
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58117812
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57624105
99Tuberculosis_Homo sapiens_hsa051520.56655967
100Glucagon signaling pathway_Homo sapiens_hsa049220.56367503
101Rap1 signaling pathway_Homo sapiens_hsa040150.55095984
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54119257
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52513616
104TNF signaling pathway_Homo sapiens_hsa046680.51654040
105Oocyte meiosis_Homo sapiens_hsa041140.51379107
106Fatty acid biosynthesis_Homo sapiens_hsa000610.49760012
107Ovarian steroidogenesis_Homo sapiens_hsa049130.49391926
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48594698
109Ras signaling pathway_Homo sapiens_hsa040140.47353948
110Alzheimers disease_Homo sapiens_hsa050100.44540466
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44275680
112African trypanosomiasis_Homo sapiens_hsa051430.42789081
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.38022128
114VEGF signaling pathway_Homo sapiens_hsa043700.37219991
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.36859003
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36449013
117Type I diabetes mellitus_Homo sapiens_hsa049400.35667475
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.34975447
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32259756
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31621312
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30931926
122Alcoholism_Homo sapiens_hsa050340.29006468
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28003907
124Chemokine signaling pathway_Homo sapiens_hsa040620.27560424
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26865060
126Wnt signaling pathway_Homo sapiens_hsa043100.26426423
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26056561
128mTOR signaling pathway_Homo sapiens_hsa041500.25109905
129Endocytosis_Homo sapiens_hsa041440.24586148
130Rheumatoid arthritis_Homo sapiens_hsa053230.22896879
131Insulin signaling pathway_Homo sapiens_hsa049100.22140415
132Platelet activation_Homo sapiens_hsa046110.21311282
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20569272
134Mineral absorption_Homo sapiens_hsa049780.20002862

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