SYNE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.19275500
2positive regulation of histone deacetylation (GO:0031065)4.61484700
3daunorubicin metabolic process (GO:0044597)4.33696621
4polyketide metabolic process (GO:0030638)4.33696621
5doxorubicin metabolic process (GO:0044598)4.33696621
6interferon-gamma production (GO:0032609)4.24979111
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.23394259
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.23394259
9modulation by symbiont of host immune response (GO:0052553)4.23394259
10positive regulation by symbiont of host defense response (GO:0052509)4.23394259
11modulation by symbiont of host defense response (GO:0052031)4.23394259
12protein localization to chromosome, centromeric region (GO:0071459)4.23393589
13positive regulation of gamma-delta T cell activation (GO:0046645)4.19707495
14negative regulation of phagocytosis (GO:0050765)4.12400171
15negative thymic T cell selection (GO:0045060)4.05585135
16positive regulation of protein deacetylation (GO:0090312)4.02751624
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01407016
18negative T cell selection (GO:0043383)4.00060494
19detection of other organism (GO:0098543)3.74315608
20cellular extravasation (GO:0045123)3.74085805
21macrophage activation involved in immune response (GO:0002281)3.71786143
22negative regulation of interleukin-12 production (GO:0032695)3.68699031
23negative regulation of erythrocyte differentiation (GO:0045647)3.67076085
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65200967
25negative regulation of T cell mediated immunity (GO:0002710)3.65197918
26mitotic sister chromatid segregation (GO:0000070)3.64858208
27positive T cell selection (GO:0043368)3.63468490
28detection of bacterium (GO:0016045)3.59536160
29nuclear pore complex assembly (GO:0051292)3.57836226
30T cell migration (GO:0072678)3.57743394
31heterochromatin organization (GO:0070828)3.56776972
32sister chromatid segregation (GO:0000819)3.54550235
33response to interleukin-15 (GO:0070672)3.51755217
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.45835770
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.44482847
36positive regulation of granulocyte differentiation (GO:0030854)3.44191936
37regulation of gamma-delta T cell differentiation (GO:0045586)3.41920480
38T cell selection (GO:0045058)3.40367580
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39935971
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39935971
41maintenance of protein location in nucleus (GO:0051457)3.37722664
42negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.35870428
43chromatin assembly (GO:0031497)3.35130965
44regulation of response to osmotic stress (GO:0047484)3.33711188
45germinal center formation (GO:0002467)3.28602082
46regulation of interferon-beta biosynthetic process (GO:0045357)3.28003152
47detection of external biotic stimulus (GO:0098581)3.25080352
48negative regulation of cell cycle G2/M phase transition (GO:1902750)3.24426044
49detection of molecule of bacterial origin (GO:0032490)3.22348117
50thymic T cell selection (GO:0045061)3.22248524
51regulation of gamma-delta T cell activation (GO:0046643)3.21869814
52cellular response to interleukin-15 (GO:0071350)3.18029322
53mRNA stabilization (GO:0048255)3.16442079
54RNA stabilization (GO:0043489)3.16442079
55neutrophil activation involved in immune response (GO:0002283)3.15566095
56activated T cell proliferation (GO:0050798)3.12052047
57response to type I interferon (GO:0034340)3.10145364
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08505190
59negative regulation of leukocyte mediated immunity (GO:0002704)3.07285395
60microglial cell activation (GO:0001774)3.07194173
61positive regulation of B cell differentiation (GO:0045579)3.06536826
62type I interferon signaling pathway (GO:0060337)3.04374088
63cellular response to type I interferon (GO:0071357)3.04374088
64antigen processing and presentation of endogenous antigen (GO:0019883)3.04044819
65response to muramyl dipeptide (GO:0032495)3.02743242
66muscle organ morphogenesis (GO:0048644)3.02435426
67mitotic chromosome condensation (GO:0007076)3.02101887
68pore complex assembly (GO:0046931)2.95136772
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92546806
70regulation of granulocyte differentiation (GO:0030852)2.92526990
71regulation of alpha-beta T cell proliferation (GO:0046640)2.92107539
72nuclear pore organization (GO:0006999)2.91472481
73defense response to protozoan (GO:0042832)2.90547369
74natural killer cell differentiation (GO:0001779)2.90356929
75response to host immune response (GO:0052572)2.90147606
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90147606
77megakaryocyte development (GO:0035855)2.89861755
78regulation of tolerance induction (GO:0002643)2.88938347
79myeloid cell activation involved in immune response (GO:0002275)2.88363373
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88201959
81interferon-gamma-mediated signaling pathway (GO:0060333)2.88059804
82detection of biotic stimulus (GO:0009595)2.87162900
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86052859
84positive thymic T cell selection (GO:0045059)2.85805657
85B cell homeostasis (GO:0001782)2.85236037
86negative regulation of T-helper cell differentiation (GO:0045623)2.80925071
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80925071
88regulation of T cell tolerance induction (GO:0002664)2.80603558
89mucosal-associated lymphoid tissue development (GO:0048537)2.79172648
90Peyers patch development (GO:0048541)2.79172648
91regulation of necroptotic process (GO:0060544)2.77936807
92negative regulation of innate immune response (GO:0045824)2.77853887
93macrophage activation (GO:0042116)2.77367571
94response to protozoan (GO:0001562)2.76969948
95negative regulation of interleukin-6 production (GO:0032715)2.76958918
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.76096688
97negative regulation of bone resorption (GO:0045779)2.75495096
98positive regulation of tolerance induction (GO:0002645)2.74124200
99regulation of telomere maintenance via telomerase (GO:0032210)2.73891494
100regulation of B cell receptor signaling pathway (GO:0050855)2.73353278
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73144024
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72637041
103response to host (GO:0075136)2.72335352
104response to host defenses (GO:0052200)2.72335352
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72335352
106regulation of antigen processing and presentation (GO:0002577)2.71598325
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70255984
108DNA unwinding involved in DNA replication (GO:0006268)2.69457546
109positive regulation of interferon-alpha production (GO:0032727)2.69427461
110adaptation of signaling pathway (GO:0023058)2.67882447
111antigen receptor-mediated signaling pathway (GO:0050851)2.67880948
112histone H4-K8 acetylation (GO:0043982)2.67445834
113histone H4-K5 acetylation (GO:0043981)2.67445834
114neutrophil activation (GO:0042119)2.66289605
115regulation of B cell differentiation (GO:0045577)2.66056815
116DNA duplex unwinding (GO:0032508)2.65853964
117negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65294576
118DNA geometric change (GO:0032392)2.64753740
119NLS-bearing protein import into nucleus (GO:0006607)2.63520269
120negative regulation of granulocyte differentiation (GO:0030853)2.63199162
121regulation of interferon-alpha production (GO:0032647)2.62991424
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62403281
123regulation of natural killer cell mediated immunity (GO:0002715)2.62280403
124regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62280403
125regulation of mast cell degranulation (GO:0043304)2.61244951
126positive regulation of isotype switching (GO:0045830)2.60935153
127response to laminar fluid shear stress (GO:0034616)2.59834873
128immunoglobulin mediated immune response (GO:0016064)2.59486138
129establishment of endothelial barrier (GO:0061028)2.58919030
130apoptotic cell clearance (GO:0043277)2.56753830
131maternal placenta development (GO:0001893)2.56077457
132negative regulation of telomerase activity (GO:0051974)2.55309988
133cytidine metabolic process (GO:0046087)2.54361634
134cytidine catabolic process (GO:0006216)2.54361634
135cytidine deamination (GO:0009972)2.54361634
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.53649191
137B cell receptor signaling pathway (GO:0050853)2.53090122
138histone H4-K16 acetylation (GO:0043984)2.51437534
139pinocytosis (GO:0006907)2.50950883
140aminoglycoside antibiotic metabolic process (GO:0030647)2.50875446
141tachykinin receptor signaling pathway (GO:0007217)2.48458099
142cellular hyperosmotic response (GO:0071474)2.48259868
143phagocytosis, recognition (GO:0006910)2.48238920
144natural killer cell activation (GO:0030101)2.46919835
145regulation of interleukin-12 biosynthetic process (GO:0045075)2.43930799
146response to UV-C (GO:0010225)2.42118836
147regulation of apoptotic cell clearance (GO:2000425)2.40614623
148negative regulation of cell killing (GO:0031342)2.40123187
149negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.40123187
150negative regulation of necroptotic process (GO:0060546)2.39653860
151hepatocyte apoptotic process (GO:0097284)2.38784860
1523-UTR-mediated mRNA stabilization (GO:0070935)2.38417032
153positive regulation of DNA-dependent DNA replication (GO:2000105)2.37971513
154leukocyte aggregation (GO:0070486)2.37143319
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36245320
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35890765
157histone H3-K4 methylation (GO:0051568)2.35608338
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.34959014
159tolerance induction (GO:0002507)2.34896418
160modulation by symbiont of host cellular process (GO:0044068)2.34202277
161positive regulation of gene expression, epigenetic (GO:0045815)2.33423090
162regulation of MHC class I biosynthetic process (GO:0045343)2.33289032
163positive regulation of protein import into nucleus, translocation (GO:0033160)2.33097129
164intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.32541598
165negative regulation of epidermis development (GO:0045683)2.31513336
166regulation of histone deacetylation (GO:0031063)2.29595557
167natural killer cell mediated cytotoxicity (GO:0042267)2.29262042
168natural killer cell mediated immunity (GO:0002228)2.29262042
169negative regulation of bone remodeling (GO:0046851)2.28745431
170positive regulation of bone remodeling (GO:0046852)2.28147636
171positive regulation of bone resorption (GO:0045780)2.28147636
172negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.27900543
173response to peptidoglycan (GO:0032494)2.27802964
174regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.27524059
175modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.27481245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.11149468
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.95566349
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.91393397
4MYC_22102868_ChIP-Seq_BL_Human3.13137870
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.09643461
6SCL_19346495_ChIP-Seq_HPC-7_Human2.81596663
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.79289617
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68447191
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.67801785
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62999179
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.50683526
12VDR_21846776_ChIP-Seq_THP-1_Human2.43108741
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33178642
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27057575
15TCF7_22412390_ChIP-Seq_EML_Mouse2.24781402
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23190938
17VDR_24787735_ChIP-Seq_THP-1_Human2.10925516
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09027698
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.08704100
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03393661
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97120018
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96940737
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96940737
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96940737
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90661204
26MAF_26560356_Chip-Seq_TH1_Human1.88078814
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81666138
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79325288
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77926462
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.77282939
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75793470
32MYB_26560356_Chip-Seq_TH1_Human1.74956537
33UTX_26944678_Chip-Seq_JUKART_Human1.73418714
34MYB_26560356_Chip-Seq_TH2_Human1.72104186
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.71862934
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70918108
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68945128
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.67810529
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66472770
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60719554
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59542897
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58559404
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55390525
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54971683
45KDM2B_26808549_Chip-Seq_DND41_Human1.54431949
46SPI1_23547873_ChIP-Seq_NB4_Human1.53604645
47SPI1_23127762_ChIP-Seq_K562_Human1.53539725
48VDR_24763502_ChIP-Seq_THP-1_Human1.53096179
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.52611958
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52069069
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50449907
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50228600
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46409063
54GATA3_26560356_Chip-Seq_TH2_Human1.46134735
55NCOR1_26117541_ChIP-Seq_K562_Human1.44299487
56RUNX_20019798_ChIP-Seq_JUKART_Human1.43090126
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42708679
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42073945
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41371170
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39842964
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38970132
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34580665
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32623364
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31944411
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31869274
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29331430
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29129845
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28465044
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28449353
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26761946
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25742052
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24312037
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22436738
74MAF_26560356_Chip-Seq_TH2_Human1.18910232
75GATA2_19941826_ChIP-Seq_K562_Human1.17693946
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16999284
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.16663459
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16496596
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14438159
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12834609
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12827573
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07497577
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.05410974
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04933768
85TP53_22127205_ChIP-Seq_IMR90_Human1.02628611
86TFEB_21752829_ChIP-Seq_HELA_Human1.02195104
87CIITA_25753668_ChIP-Seq_RAJI_Human1.01708583
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01694786
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01485119
90GATA3_27048872_Chip-Seq_THYMUS_Human0.97245075
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96687188
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.94825468
93SMRT_27268052_Chip-Seq_Bcells_Human0.94465286
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94407793
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94363088
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93933363
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93865381
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93015557
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92511497
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.92296613
101LXR_22292898_ChIP-Seq_THP-1_Human0.92007658
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91661171
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.89297576
104GATA1_19941826_ChIP-Seq_K562_Human0.89060553
105RACK7_27058665_Chip-Seq_MCF-7_Human0.88888912
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88742718
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.88319860
108AR_21909140_ChIP-Seq_LNCAP_Human0.88046873
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87924353
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86456819
111P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85519136
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84435544
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84089277
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83854831
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81570555
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80401026
117DROSHA_22980978_ChIP-Seq_HELA_Human0.80182469
118ATF3_27146783_Chip-Seq_COLON_Human0.79839462
119GATA1_22025678_ChIP-Seq_K562_Human0.79813885
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79590379
121PU_27001747_Chip-Seq_BMDM_Mouse0.79431175
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79318529
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78977540
124GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77977918
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76784826
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67372541
127RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65698192
128KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.65398133
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64121741
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.62558484
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.60756288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.66457306
2MP0003705_abnormal_hypodermis_morpholog3.25716403
3MP0002396_abnormal_hematopoietic_system2.63309909
4MP0010352_gastrointestinal_tract_polyps2.56483881
5MP0003300_gastrointestinal_ulcer2.42991729
6MP0003011_delayed_dark_adaptation2.30191593
7MP0003436_decreased_susceptibility_to2.22302794
8MP0001835_abnormal_antigen_presentation2.21997797
9MP0008438_abnormal_cutaneous_collagen2.10582819
10MP0001800_abnormal_humoral_immune2.07272439
11MP0000685_abnormal_immune_system2.04452252
12MP0009278_abnormal_bone_marrow2.03239552
13MP0003303_peritoneal_inflammation1.97503479
14MP0004808_abnormal_hematopoietic_stem1.96982709
15MP0001790_abnormal_immune_system1.95120591
16MP0005387_immune_system_phenotype1.95120591
17MP0008057_abnormal_DNA_replication1.92854994
18MP0000569_abnormal_digit_pigmentation1.91599436
19MP0006082_CNS_inflammation1.89476846
20MP0002398_abnormal_bone_marrow1.75553847
21MP0002452_abnormal_antigen_presenting1.72523423
22MP0005000_abnormal_immune_tolerance1.71160342
23MP0004264_abnormal_extraembryonic_tissu1.69058583
24MP0010307_abnormal_tumor_latency1.67718141
25MP0005397_hematopoietic_system_phenotyp1.66199743
26MP0001545_abnormal_hematopoietic_system1.66199743
27MP0000689_abnormal_spleen_morphology1.64745217
28MP0005671_abnormal_response_to1.64396942
29MP0003566_abnormal_cell_adhesion1.63952249
30MP0002420_abnormal_adaptive_immunity1.62224358
31MP0002405_respiratory_system_inflammati1.61661709
32MP0004130_abnormal_muscle_cell1.61653525
33MP0005076_abnormal_cell_differentiation1.61568665
34MP0002722_abnormal_immune_system1.59961289
35MP0001819_abnormal_immune_cell1.59655333
36MP0005257_abnormal_intraocular_pressure1.58876023
37MP0002166_altered_tumor_susceptibility1.58017321
38MP0002723_abnormal_immune_serum1.56764103
39MP0002254_reproductive_system_inflammat1.55755629
40MP0005075_abnormal_melanosome_morpholog1.54216558
41MP0004947_skin_inflammation1.53434831
42MP0005023_abnormal_wound_healing1.51283243
43MP0005025_abnormal_response_to1.50361966
44MP0004381_abnormal_hair_follicle1.49547619
45MP0002138_abnormal_hepatobiliary_system1.48155580
46MP0000716_abnormal_immune_system1.48044077
47MP0003448_altered_tumor_morphology1.46840061
48MP0005464_abnormal_platelet_physiology1.44207090
49MP0002877_abnormal_melanocyte_morpholog1.43796489
50MP0002933_joint_inflammation1.41633327
51MP0002009_preneoplasia1.41427890
52MP0002429_abnormal_blood_cell1.38282924
53MP0002419_abnormal_innate_immunity1.37777003
54MP0000703_abnormal_thymus_morphology1.36157978
55MP0003191_abnormal_cellular_cholesterol1.35702342
56MP0008961_abnormal_basal_metabolism1.35151190
57MP0000490_abnormal_crypts_of1.35108644
58MP0003111_abnormal_nucleus_morphology1.34653523
59MP0003077_abnormal_cell_cycle1.34504617
60MP0003183_abnormal_peptide_metabolism1.34070252
61MP0003763_abnormal_thymus_physiology1.31021333
62MP0009764_decreased_sensitivity_to1.29156735
63MP0010155_abnormal_intestine_physiology1.28150517
64MP0009333_abnormal_splenocyte_physiolog1.27864834
65MP0003091_abnormal_cell_migration1.25845454
66MP0000858_altered_metastatic_potential1.23958354
67MP0009785_altered_susceptibility_to1.22161878
68MP0008469_abnormal_protein_level1.19161851
69MP0001851_eye_inflammation1.18867604
70MP0004957_abnormal_blastocyst_morpholog1.18542417
71MP0003866_abnormal_defecation1.17962900
72MP0004883_abnormal_blood_vessel1.17763526
73MP0000015_abnormal_ear_pigmentation1.17741608
74MP0000465_gastrointestinal_hemorrhage1.17640215
75MP0003172_abnormal_lysosome_physiology1.15960503
76MP0002006_tumorigenesis1.14286606
77MP0003279_aneurysm1.13962450
78MP0000350_abnormal_cell_proliferation1.13907772
79MP0004510_myositis1.10781997
80MP0001243_abnormal_dermal_layer1.10199974
81MP0010094_abnormal_chromosome_stability1.09107701
82MP0002019_abnormal_tumor_incidence1.08609225
83MP0005164_abnormal_response_to1.08518489
84MP0002088_abnormal_embryonic_growth/wei1.07279739
85MP0005451_abnormal_body_composition1.06750489
86MP0003984_embryonic_growth_retardation1.06224246
87MP0002332_abnormal_exercise_endurance1.05209510
88MP0001853_heart_inflammation1.04585207
89MP0001672_abnormal_embryogenesis/_devel1.03847910
90MP0005380_embryogenesis_phenotype1.03847910
91MP0005670_abnormal_white_adipose1.02824417
92MP0000733_abnormal_muscle_development1.02131325
93MP0001845_abnormal_inflammatory_respons1.01366148
94MP0002086_abnormal_extraembryonic_tissu0.97036644
95MP0001533_abnormal_skeleton_physiology0.96834897
96MP0008260_abnormal_autophagy0.96023765
97MP0003656_abnormal_erythrocyte_physiolo0.95316133
98MP0000249_abnormal_blood_vessel0.94752861
99MP0001958_emphysema0.94649337
100MP0002970_abnormal_white_adipose0.91760094
101MP0005666_abnormal_adipose_tissue0.90725956
102MP0003828_pulmonary_edema0.89934928
103MP0001873_stomach_inflammation0.88879037
104MP0002971_abnormal_brown_adipose0.88216355
105MP0000343_altered_response_to0.87544567
106MP0002060_abnormal_skin_morphology0.87186414
107MP0003690_abnormal_glial_cell0.85752321
108MP0002998_abnormal_bone_remodeling0.85324546
109MP0009115_abnormal_fat_cell0.84063275
110MP0008770_decreased_survivor_rate0.83876284
111MP0005058_abnormal_lysosome_morphology0.83835370
112MP0000313_abnormal_cell_death0.83664241
113MP0008007_abnormal_cellular_replicative0.83302442
114MP0002148_abnormal_hypersensitivity_rea0.83251126
115MP0005390_skeleton_phenotype0.83136664
116MP0002132_abnormal_respiratory_system0.81814413
117MP0005621_abnormal_cell_physiology0.81805398
118MP0001915_intracranial_hemorrhage0.81724520
119MP0003890_abnormal_embryonic-extraembry0.80982344
120MP0000767_abnormal_smooth_muscle0.80257743
121MP0004185_abnormal_adipocyte_glucose0.79471046
122MP0003045_fibrosis0.79070973
123MP0009763_increased_sensitivity_to0.78398006
124MP0000609_abnormal_liver_physiology0.78321383
125MP0005310_abnormal_salivary_gland0.78305103
126MP0005174_abnormal_tail_pigmentation0.77953497
127MP0000371_diluted_coat_color0.76875964
128MP0008004_abnormal_stomach_pH0.76390658
129MP0003075_altered_response_to0.75952332
130MP0003646_muscle_fatigue0.74849561
131MP0001663_abnormal_digestive_system0.72234024
132MP0000604_amyloidosis0.67710439
133MP0005334_abnormal_fat_pad0.67268785
134MP0005535_abnormal_body_temperature0.66059377
135MP0005166_decreased_susceptibility_to0.65022280
136MP0005375_adipose_tissue_phenotype0.64695090
137MP0001986_abnormal_taste_sensitivity0.63236591

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.16148483
2Retrobulbar optic neuritis (HP:0100654)4.16148483
3Stomatitis (HP:0010280)3.91722839
4Recurrent cutaneous fungal infections (HP:0011370)3.76083686
5Chronic mucocutaneous candidiasis (HP:0002728)3.76083686
6Hypochromic microcytic anemia (HP:0004840)3.60131646
7Abnormality of macrophages (HP:0004311)3.55635104
8Gastrointestinal infarctions (HP:0005244)3.42691726
9Mediastinal lymphadenopathy (HP:0100721)3.38555676
10Recurrent skin infections (HP:0001581)3.33305075
11Keratoconjunctivitis sicca (HP:0001097)3.33138715
12Recurrent gram-negative bacterial infections (HP:0005420)3.28104515
13Cellulitis (HP:0100658)3.25615118
14Increased connective tissue (HP:0009025)3.15333283
15Keratoconjunctivitis (HP:0001096)3.13488266
16Encephalitis (HP:0002383)3.11897518
17Pulmonary infiltrates (HP:0002113)3.05997627
18Nasal polyposis (HP:0100582)3.04513092
19Peritonitis (HP:0002586)2.98890451
20Granulocytopenia (HP:0001913)2.87896075
21Autoimmune hemolytic anemia (HP:0001890)2.85125873
22Eosinophilia (HP:0001880)2.82744525
23Myositis (HP:0100614)2.81999521
24Hemoptysis (HP:0002105)2.81605248
25Increased IgE level (HP:0003212)2.78150463
26Gastrointestinal stroma tumor (HP:0100723)2.78005968
27Absent frontal sinuses (HP:0002688)2.76574653
28Multiple enchondromatosis (HP:0005701)2.70098821
29Abnormality of B cell number (HP:0010975)2.68358289
30Elevated erythrocyte sedimentation rate (HP:0003565)2.66772487
31Ulnar bowing (HP:0003031)2.66225502
32Protrusio acetabuli (HP:0003179)2.61354736
33Recurrent viral infections (HP:0004429)2.60447510
34Bilateral microphthalmos (HP:0007633)2.58310763
35Hematochezia (HP:0002573)2.58282322
36Recurrent abscess formation (HP:0002722)2.55265940
37Hypochromic anemia (HP:0001931)2.54529450
38Osteolytic defects of the hand bones (HP:0009699)2.54092779
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.54092779
40Lymphopenia (HP:0001888)2.54077585
41Abnormality of the nasal mucosa (HP:0000433)2.53617796
42Arterial thrombosis (HP:0004420)2.48848056
43Obstructive lung disease (HP:0006536)2.47898718
44Chronic obstructive pulmonary disease (HP:0006510)2.47898718
45Abnormality of eosinophils (HP:0001879)2.46118467
46Increased density of long bones (HP:0006392)2.39639482
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.38758282
48Premature rupture of membranes (HP:0001788)2.35915125
49Periodontitis (HP:0000704)2.35137089
50Urticaria (HP:0001025)2.34461369
51Orchitis (HP:0100796)2.33573276
52Cerebral aneurysm (HP:0004944)2.30280006
53Abnormality of the fingertips (HP:0001211)2.29716975
54Pulmonary embolism (HP:0002204)2.29492673
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29432963
56Recurrent fungal infections (HP:0002841)2.29149401
57Eczematoid dermatitis (HP:0000976)2.27687762
58Mitral valve prolapse (HP:0001634)2.27375927
59Recurrent bacterial skin infections (HP:0005406)2.25772461
60IgG deficiency (HP:0004315)2.22727519
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21799177
62Abnormality of the pleura (HP:0002103)2.18357839
63Ankle contracture (HP:0006466)2.17593220
64Chromsome breakage (HP:0040012)2.16984453
65Myocardial infarction (HP:0001658)2.15291428
66Viral hepatitis (HP:0006562)2.14268557
67Severe combined immunodeficiency (HP:0004430)2.13682813
68B lymphocytopenia (HP:0010976)2.13323776
69Abnormal platelet volume (HP:0011876)2.11448505
70Increased cerebral lipofuscin (HP:0011813)2.09446825
71Combined immunodeficiency (HP:0005387)2.08892570
72Dysostosis multiplex (HP:0000943)2.08760145
73Amyloidosis (HP:0011034)2.07457201
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.07274828
75Abnormality of the lower motor neuron (HP:0002366)2.07163908
76Macroorchidism (HP:0000053)2.06836496
77Chest pain (HP:0100749)2.06578455
78Thyroiditis (HP:0100646)2.06025217
79Gingivitis (HP:0000230)2.05584330
80Hypoplasia of the thymus (HP:0000778)2.05462882
81Prolonged bleeding time (HP:0003010)2.05179759
82Microcytic anemia (HP:0001935)2.03821685
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03440572
84Hand muscle atrophy (HP:0009130)2.01930101
85Colitis (HP:0002583)2.01437486
86Recurrent lower respiratory tract infections (HP:0002783)2.01256506
87Ependymoma (HP:0002888)2.01048238
88Papilledema (HP:0001085)2.00403512
89Upper limb amyotrophy (HP:0009129)2.00004664
90Distal upper limb amyotrophy (HP:0007149)2.00004664
91Large earlobe (HP:0009748)1.99222819
92Increased IgM level (HP:0003496)1.99122402
93Rib fusion (HP:0000902)1.98728057
94Gingival bleeding (HP:0000225)1.97454417
95Spondylolisthesis (HP:0003302)1.97394144
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.97112374
97Dislocated radial head (HP:0003083)1.95752445
98Syringomyelia (HP:0003396)1.95272164
99Spinal cord lesions (HP:0100561)1.95272164
100IgA deficiency (HP:0002720)1.94946151
101Recurrent bronchitis (HP:0002837)1.94355997
102Recurrent pneumonia (HP:0006532)1.94337659
103Prominent nose (HP:0000448)1.94280309
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93470346
105Inflammation of the large intestine (HP:0002037)1.93296393
106Gastrointestinal inflammation (HP:0004386)1.90507107
107Skin tags (HP:0010609)1.90484697
108Gangrene (HP:0100758)1.89446024
109Episodic fever (HP:0001954)1.89402713
110Chronic diarrhea (HP:0002028)1.88352172
111T lymphocytopenia (HP:0005403)1.87860920
112Sepsis (HP:0100806)1.87796513
113IgM deficiency (HP:0002850)1.87744037
114Agammaglobulinemia (HP:0004432)1.87670615
115Abnormality of glycolipid metabolism (HP:0010969)1.87435984
116Abnormality of liposaccharide metabolism (HP:0010968)1.87435984
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.87435984
118Keratitis (HP:0000491)1.87229973
119Heterotopia (HP:0002282)1.86972034
120Increased mean platelet volume (HP:0011877)1.85455682
121Preauricular skin tag (HP:0000384)1.83974450
122Petechiae (HP:0000967)1.83829452
123Meningitis (HP:0001287)1.83584744
124Cheilitis (HP:0100825)1.83269710
125Radial bowing (HP:0002986)1.82616514
126Panhypogammaglobulinemia (HP:0003139)1.82574994
127Leukocytosis (HP:0001974)1.82178385
128Pustule (HP:0200039)1.81860397
129Autoimmune thrombocytopenia (HP:0001973)1.81528440
130Broad palm (HP:0001169)1.81227223
131Abnormality of the peritoneum (HP:0002585)1.80354809
132Distal lower limb amyotrophy (HP:0008944)1.80135488
133Cervical subluxation (HP:0003308)1.79073041
134Increased serum ferritin (HP:0003281)1.77887610
135Dilatation of the ascending aorta (HP:0005111)1.77874383
136Abnormality of the radial head (HP:0003995)1.77828849
137Osteomyelitis (HP:0002754)1.76947773
138Impaired platelet aggregation (HP:0003540)1.76255743
139Abnormal platelet function (HP:0011869)1.76255743
140Papilloma (HP:0012740)1.75432176
141Verrucae (HP:0200043)1.75432176
142Epistaxis (HP:0000421)1.73720855
143Abnormality of T cell number (HP:0011839)1.73168049
144Emphysema (HP:0002097)1.72797902
145Neoplasm of striated muscle (HP:0009728)1.72725603
146Vasculitis (HP:0002633)1.72152462
147Genu recurvatum (HP:0002816)1.71929393
148Hepatoblastoma (HP:0002884)1.71646569
149Difficulty running (HP:0009046)1.71242047
150Disproportionate tall stature (HP:0001519)1.70726021
151Abnormality of T cell physiology (HP:0011840)1.69291148
152Restrictive lung disease (HP:0002091)1.67393404
153Short 5th finger (HP:0009237)1.65484515
154Abnormality of T cells (HP:0002843)1.65413920
155Abnormal cartilage morphology (HP:0002763)1.64961324
156Spontaneous hematomas (HP:0007420)1.63995266
157Myelodysplasia (HP:0002863)1.63928425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.74265699
2ERN13.87534061
3RIPK43.36620917
4GRK63.16085674
5PRPF4B2.94504865
6EEF2K2.81159968
7MAP3K102.80686434
8STK102.77827339
9MAP4K12.69651997
10CSF1R2.60837124
11TRIB32.48609153
12TGFBR21.93357645
13TTN1.82310134
14PKN21.75215603
15GRK51.74513122
16MAP3K131.65446113
17NEK21.51000649
18KIT1.46989822
19FRK1.46885513
20GRK11.38762610
21CAMK1D1.34976363
22TTK1.34537888
23FGFR31.32301775
24JAK31.31831806
25TYK21.27662708
26MOS1.25899389
27MAPK71.25180153
28RIPK11.23185552
29ITK1.22545823
30SIK11.21844292
31CSK1.20396263
32MAP3K31.20184237
33SIK21.17380811
34TAOK31.16471374
35MAP2K31.13577156
36MATK1.12914681
37CDC42BPA1.11806044
38NLK1.09055550
39PIK3CG1.07463234
40PAK41.06290998
41ZAP701.04557500
42LRRK21.03559836
43BLK1.02304067
44TRPM71.01818587
45PIM11.01469420
46JAK11.00786830
47IKBKB1.00086871
48CDK40.99709340
49ADRBK20.97846988
50EPHB10.97627709
51HCK0.97218652
52MAP3K140.94202186
53IRAK10.91943625
54MTOR0.91085052
55CAMKK20.90439650
56PTK60.90300390
57HIPK20.89102716
58MAP3K70.87561678
59STK40.87440774
60TBK10.87027910
61BMPR20.85753422
62PDK10.85414945
63MARK20.85372635
64MAP3K10.85269448
65CDK70.84145312
66WNK10.82878039
67SYK0.82667009
68BTK0.81931418
69ALK0.81824648
70CDC70.81451968
71CHUK0.81301688
72IRAK30.80491161
73PRKCQ0.80070135
74CDK60.79630996
75STK30.79342750
76CAMK1G0.79332149
77SGK20.79115701
78BMX0.78692513
79FGR0.78262016
80MAP3K110.78247667
81LCK0.75285412
82CAMKK10.74758279
83CLK10.74325283
84TYRO30.73121724
85RPS6KA40.70861487
86PTK2B0.69966263
87SGK30.68433847
88PRKD20.68368201
89CAMK40.66266100
90MAP3K60.64868665
91PDPK10.64596737
92GRK70.64438654
93PRKG20.63087039
94EPHA30.62462550
95PRKAA20.61529916
96FGFR40.61429394
97TXK0.60945907
98MAPK120.60529388
99MELK0.60146069
100RPS6KB20.60041507
101FLT30.57844629
102CHEK20.57291522
103MAP3K80.57238789
104JAK20.57189967
105CHEK10.53476862
106MARK30.52903726
107NEK90.51895632
108PDGFRA0.51879397
109YES10.50290826
110PAK20.49301380
111AURKB0.49175700
112RPS6KA60.48962078
113PLK10.48772712
114IRAK40.46392765
115PDGFRB0.46315873
116IKBKE0.45603713
117RPS6KC10.44701141
118RPS6KL10.44701141
119RET0.44184536
120FES0.43433709
121SIK30.42490582
122BRD40.42413849
123LYN0.41951783
124MAPK110.39479753
125IRAK20.39467705
126CDK90.39156652
127ATR0.38788639
128MAPK40.38187820
129TEC0.37710513
130PRKCH0.37557619
131TNK20.37557408
132DDR20.37275230
133TAOK20.37249406
134FYN0.36760538
135MAPKAPK20.36454466
136ABL10.36337579
137MAPK30.36193997
138TAOK10.35952917

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053202.25669513
2B cell receptor signaling pathway_Homo sapiens_hsa046622.22747422
3Vitamin B6 metabolism_Homo sapiens_hsa007502.22501289
4Primary immunodeficiency_Homo sapiens_hsa053402.13506084
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96318121
6Leishmaniasis_Homo sapiens_hsa051401.96244434
7Asthma_Homo sapiens_hsa053101.94422252
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.93626719
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77745292
10Type I diabetes mellitus_Homo sapiens_hsa049401.75119899
11Osteoclast differentiation_Homo sapiens_hsa043801.72125790
12Acute myeloid leukemia_Homo sapiens_hsa052211.61921600
13Chronic myeloid leukemia_Homo sapiens_hsa052201.61487017
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61139549
15Caffeine metabolism_Homo sapiens_hsa002321.60353796
16Measles_Homo sapiens_hsa051621.51050093
17Apoptosis_Homo sapiens_hsa042101.49167288
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.47965894
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42744445
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41145232
21Toxoplasmosis_Homo sapiens_hsa051451.41142998
22Malaria_Homo sapiens_hsa051441.40522692
23Small cell lung cancer_Homo sapiens_hsa052221.37620791
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36338781
25Pancreatic cancer_Homo sapiens_hsa052121.33857324
26Antigen processing and presentation_Homo sapiens_hsa046121.33783253
27mTOR signaling pathway_Homo sapiens_hsa041501.33746680
28T cell receptor signaling pathway_Homo sapiens_hsa046601.33185515
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.33079876
30Hematopoietic cell lineage_Homo sapiens_hsa046401.32216220
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30749515
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.28532504
33Staphylococcus aureus infection_Homo sapiens_hsa051501.27179014
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26515534
35MicroRNAs in cancer_Homo sapiens_hsa052061.26210688
36Herpes simplex infection_Homo sapiens_hsa051681.19811569
37Non-small cell lung cancer_Homo sapiens_hsa052231.16569517
38Dorso-ventral axis formation_Homo sapiens_hsa043201.14738716
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.14299778
40Viral carcinogenesis_Homo sapiens_hsa052031.14122502
41Platelet activation_Homo sapiens_hsa046111.12546558
42DNA replication_Homo sapiens_hsa030301.10769162
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09357564
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09231128
45Lysine degradation_Homo sapiens_hsa003101.09144812
46Viral myocarditis_Homo sapiens_hsa054161.08708636
47Fructose and mannose metabolism_Homo sapiens_hsa000511.07109960
48Cell cycle_Homo sapiens_hsa041101.04864528
49Hepatitis B_Homo sapiens_hsa051611.04661370
50p53 signaling pathway_Homo sapiens_hsa041151.01962457
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01427840
52African trypanosomiasis_Homo sapiens_hsa051431.01293853
53Influenza A_Homo sapiens_hsa051641.00127376
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99753199
55Proteoglycans in cancer_Homo sapiens_hsa052050.98797670
56TNF signaling pathway_Homo sapiens_hsa046680.98667247
57Tuberculosis_Homo sapiens_hsa051520.98362709
58HTLV-I infection_Homo sapiens_hsa051660.97831413
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96515160
60One carbon pool by folate_Homo sapiens_hsa006700.95698176
61Rheumatoid arthritis_Homo sapiens_hsa053230.94970536
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93090256
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91524869
64Legionellosis_Homo sapiens_hsa051340.90601032
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90352090
66Other glycan degradation_Homo sapiens_hsa005110.90219824
67Shigellosis_Homo sapiens_hsa051310.88579358
68Focal adhesion_Homo sapiens_hsa045100.87285415
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86240109
70FoxO signaling pathway_Homo sapiens_hsa040680.84434735
71Galactose metabolism_Homo sapiens_hsa000520.83550487
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.83117914
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.81331023
74Insulin resistance_Homo sapiens_hsa049310.80025433
75VEGF signaling pathway_Homo sapiens_hsa043700.79221261
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.78428141
77Chemokine signaling pathway_Homo sapiens_hsa040620.77601221
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76645327
79Inositol phosphate metabolism_Homo sapiens_hsa005620.76606909
80Phagosome_Homo sapiens_hsa041450.76106568
81Allograft rejection_Homo sapiens_hsa053300.74846493
82Notch signaling pathway_Homo sapiens_hsa043300.74815784
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73428543
84ECM-receptor interaction_Homo sapiens_hsa045120.71662303
85Type II diabetes mellitus_Homo sapiens_hsa049300.69975011
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69493945
87HIF-1 signaling pathway_Homo sapiens_hsa040660.68935948
88Pertussis_Homo sapiens_hsa051330.68909534
89Base excision repair_Homo sapiens_hsa034100.68360053
90Hepatitis C_Homo sapiens_hsa051600.67774327
91Renal cell carcinoma_Homo sapiens_hsa052110.67139231
92Systemic lupus erythematosus_Homo sapiens_hsa053220.66770992
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66622314
94Non-homologous end-joining_Homo sapiens_hsa034500.65327013
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.64756564
96Complement and coagulation cascades_Homo sapiens_hsa046100.64326291
97Fanconi anemia pathway_Homo sapiens_hsa034600.63781001
98GnRH signaling pathway_Homo sapiens_hsa049120.63174089
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61331448
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61015710
101MAPK signaling pathway_Homo sapiens_hsa040100.60850464
102Graft-versus-host disease_Homo sapiens_hsa053320.60290325
103Amoebiasis_Homo sapiens_hsa051460.60232672
104Pathways in cancer_Homo sapiens_hsa052000.59906283
105Prolactin signaling pathway_Homo sapiens_hsa049170.57959301
106Choline metabolism in cancer_Homo sapiens_hsa052310.57786508
107Renin-angiotensin system_Homo sapiens_hsa046140.56687712
108AMPK signaling pathway_Homo sapiens_hsa041520.56338900
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.56005382
110Lysosome_Homo sapiens_hsa041420.54352404
111RNA transport_Homo sapiens_hsa030130.54186125
112mRNA surveillance pathway_Homo sapiens_hsa030150.53355789
113Prostate cancer_Homo sapiens_hsa052150.52867578
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52359851
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51623962
116Colorectal cancer_Homo sapiens_hsa052100.51177213
117Epstein-Barr virus infection_Homo sapiens_hsa051690.51057685
118Glioma_Homo sapiens_hsa052140.50566269
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50412462
120ABC transporters_Homo sapiens_hsa020100.50063892
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49727621
122Pentose phosphate pathway_Homo sapiens_hsa000300.48665629
123Endometrial cancer_Homo sapiens_hsa052130.45138986
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.44176034
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.42373350
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42339849
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38034499
128Glycerolipid metabolism_Homo sapiens_hsa005610.37429856
129Salmonella infection_Homo sapiens_hsa051320.34537234
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34509835

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